BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765  93 TSKYIYQTLFLNGENSDIKICALGEEWSLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDVEALQVAFGSLYRD 172
Cdd:cd18305   1 TSKYIYQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGSLYRD 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 30410765 173 DVLIKPSRVVAILAAACLLQLDGLIQQCGETMKET 207
Cdd:cd18305  81 EIEIKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765  93 TSKYIYQTLFLNGENSDIKICALGEEWSLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDVEALQVAFGSLYRD 172
Cdd:cd18305   1 TSKYIYQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGSLYRD 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 30410765 173 DVLIKPSRVVAILAAACLLQLDGLIQQCGETMKET 207
Cdd:cd18305  81 EIEIKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765    98 YQTLFLNGENSDIKICALGEEWSLHKIYLC-QSGYFSSMFSGSWKESSMNIIELEipdqNIDVEALQVAFGSLYRDDvLI 176
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAaCSPYFKALFSGQESESSVSEITLD----DVSPEDFEALLEFMYTGK-LI 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 30410765   177 KPSRVVAILAAACLLQLDGLIQQCGETMKET 207
Cdd:pfam00651  76 SEENVDDLLAAADKLQIPSLVDKCEEFLIKS 106

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30410765    213 VCGYYTSAGTYGLDSVKKKCLEWLLNNLMTHQNVELFKELSINVMKQLIGSSNLFVMQvEMDIYTALKKWM 283
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSS-EEEVFEAVLRWV 70

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765  93 TSKYIYQTLFLNGENSDIKICALGEEWSLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDVEALQVAFGSLYRD 172
Cdd:cd18305   1 TSKYIYQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGSLYRD 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 30410765 173 DVLIKPSRVVAILAAACLLQLDGLIQQCGETMKET 207
Cdd:cd18305  81 EIEIKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765  96 YIYQTLFLNGENSDIKICALGEEWSLHKIYLCQSGYFSSMFSgswkessMNIIELEIPDQNIDVEALQVAFGSLYRDDVL 175
Cdd:cd18291   1 YYHSQKVARSACPDVVLECLGSFWELHSPYLCKSETLAELLK-------PVTISLNINDPLVTKEAFAVALGNLYNSEVE 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 30410765 176 IKPSRVVAILAAACLLQLDGLIQQCGETMKETVNVKTVCGY 216
Cdd:cd18291  74 VNVEDAVGVLAAAALLRFPTLFQKCVKVMISSISSSTVCKF 114

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765    98 YQTLFLNGENSDIKICALGEEWSLHKIYLC-QSGYFSSMFSGSWKESSMNIIELEipdqNIDVEALQVAFGSLYRDDvLI 176
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAaCSPYFKALFSGQESESSVSEITLD----DVSPEDFEALLEFMYTGK-LI 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 30410765   177 KPSRVVAILAAACLLQLDGLIQQCGETMKET 207
Cdd:pfam00651  76 SEENVDDLLAAADKLQIPSLVDKCEEFLIKS 106

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765    109 DIKICALGEEWSLHKIYLCQ-SGYFSSMFSGSWKESSMNIIELEipdqNIDVEALQVAFGSLYRDDVLIKPSRVVAILAA 187
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAhSPYFKALFSSDFKESDKSEIYLD----DVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90
                   ....*....|....*....
gi 30410765    188 ACLLQLDGLIQQCGETMKE 206
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLK 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765  78 QQRLLNTPRRKKLKSTSKYIYQTLFLngenSDIKICALGEEWSLHKIYLCQ-SGYFSSMFSGSWKESSMNIIELeipdQN 156
Cdd:cd18270   1 DERQINTEYAVSLLEQLKFFYEQQLL----TDIVLIVEGTEFPCHKMVLATcSSYFRAMFMSGLSESKQTHVHL----RN 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 30410765 157 IDVEALQVAFGSLYRDDVLIKPSRVVAILAAACLLQLDGLIQQCGETMKETVNVK 211
Cdd:cd18270  73 VDAATLQIIITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 127

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB-domain-containing Kelch-like protein. Its function remains unclear. BTBD16 SNPs may be bipolar disorder (BD) genetic susceptibility variants exhibiting genetic background-dependent effects.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 208 VNVKTVCGYYTSAGTYGLDSVKKKCLEWLLNNLMTHQNVEL-FKELSINVMKQLIGSSNLFVMQvEMDIYTALKKWMFLQ 286
Cdd:cd18492   1 IKSSTVCKFHRAACKYKQESLATACERWLELNLVPQLSSQIyLRDLPLELLHKILKSPRLFTFN-EYSLYKTLCYWVFLQ 79

                ....
gi 30410765 287 LVPS 290
Cdd:cd18492  80 LNPK 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 108 SDIKICALGEEWSLHKIYLCQ-SGYFSSMFSGSWKESSMNIIELeipdQNIDVEALQVAFGSLYRDDVLIKPSRVVAILA 186
Cdd:cd18265  24 TDVVLLVDGKDFPCHRATLSAnSAYFRAMFGGHLKESRQAVVEI----QKVSAAAMEVLLDYMYGGGLRIQEDNVESVLE 99

                        90
                ....*....|....
gi 30410765 187 AACLLQLDGLIQQC 200
Cdd:cd18265 100 ASDLLQVSKLREAC 113

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 109 DIKICALGEEWSLHKIYLC-QSGYFSSMFSGSWKESSMNIIE---LEIPDQNIDVEALQVAFgsLYRDDVLIKPSRVVAI 184
Cdd:cd18296  19 DVCFQVEGHRFPCHKAFFCgRSDYFKALLRDHFAESEENNGSipvVTLHDVSPEVFAIVLYY--IYTDDTDLPPENAYDV 96

                        90       100
                ....*....|....*....|
gi 30410765 185 LAAACLLQLDGLIQQCGETM 204
Cdd:cd18296  97 LYVADMYLLPGLKRLCGTVL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 109 DIKICALGEEWSLHKIYL--CqSGYFSSMFSGSWKESSMNIIELeipdQNIDVEALQVAFGSLYRDDVLIKPSRVVAILA 186
Cdd:cd18235  23 DVILVADGVEIPAHRVVLasC-SPYFHAMFTGDLSESRANRVTL----QDVDGKALLLLIDYVYTAEIQVTEENVQVLLP 97

                        90
                ....*....|....*.
gi 30410765 187 AACLLQLDGLIQQCGE 202
Cdd:cd18235  98 AANLLQLTDVRDACCD 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 108 SDIKICALGEEWSLHKIYLCQ-SGYFSSMFSGSWKESSMNIIELeipdQNIDVEALQVAFGSLYRDDVLIKPSRVVAILA 186
Cdd:cd18250  22 FDVTLCAGGREFPCHRTVLAAaSSYFRAMFAGELRESRADRVVL----HGVSAEILGLLLDFSYTGRVTVTQDNVEALLR 97

                        90       100
                ....*....|....*....|....
gi 30410765 187 AACLLQLDGLIQQCGETMKETVNV 210
Cdd:cd18250  98 AADLFQFPSVKEACCAYLQQRLDV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765  98 YQTLFLNGENSDIKICALGEEWSLHKIYL-CQSGYFSSMFSGSWKESSMNIIELEIPdqniDVEALQVAFGSLYRDDVLI 176
Cdd:cd18264  19 YQSLRAEGFLCDVVLEAEGNEFPAHRSLLaCSSDYFRALFKDYTQESKARVIHLPVV----SAAGLQRVLDFIYTSWLSL 94

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 30410765 177 KPSRVVAILAAACLLQLDGLIQQCGETMKETVNVKTVC 214
Cdd:cd18264  95 SLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCC 132

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765  100 TLFLNGENSDIKIC--ALGEEWSLHKIYLCQ-SGYFSSMFSGSWKESSMNIieleipdqNIDVEALQVAFGSLYRDDVLI 176
Cdd:PHA03098   2 YSFELQKFCDESIIivNGGGIIKVHKIILSSsSEYFKKMFKNNFKENEINL--------NIDYDSFNEVIKYIYTGKINI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765  177 KPSRVVAILAAACLLQLDGLIQQCGETMKETVNVKTVCGYYTSAGTYGLDSVKKKCLEWLLNNLMTHQNVELFKELSINV 256
Cdd:PHA03098  74 TSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNE 153

                        170
                 ....*....|..
gi 30410765  257 MKQLIGSSNLFV 268
Cdd:PHA03098 154 LIKILSDDKLNV 165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765  99 QTLFLNGENSDIKI-CALGEEWSLHKIYLCQ-SGYFSSMFSGSWKESSmniiELEIPDQNIDVEALQVAFGSLYRDDVLI 176
Cdd:cd18274  14 KAMYDEGQLTDIVVeVDHGKTFSCHRNVLAAiSPYFRSMFTSGLTEST----QKEVRIVGVEAESMHLVLDYAYTSRVTL 89

                        90       100
                ....*....|....*....|....*...
gi 30410765 177 KPSRVVAILAAACLLQLDGLIQQCGETM 204
Cdd:cd18274  90 TEANVQALFTAASIFQIPSLQDQCAQFM 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 109 DIKICALGEEWSLHKIYL--CqSGYFSSMFSGSWKESSMNIIELeipdQNIDVEALQVAFGSLYRDDVLIKPSRVVAILA 186
Cdd:cd18255  20 DVTLIADGQRFQAHKVVLasC-SDYFRAMFTGGMRESSQDEIEL----KGVSAKGLKHILDFAYTSELTLDLDCIQDVLG 94

                        90       100
                ....*....|....*....|....*.
gi 30410765 187 AACLLQLDGLIQQCGETMKETVNVKT 212
Cdd:cd18255  95 AAVHLQMLPVVELCEEFLKSAMSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 108 SDIKICALGEEWSLHKIYL-CQSGYFSSMFSGSWKESSMNIIELeipdQNIDVEALQVAFGSLYRDDVLIKPSRVVAILA 186
Cdd:cd18272  33 ADVTISVEGKEFQLHRLVLsAQSCFFRSMFTSNLKEARNRVIEL----KDVSESVFQLLVDYIYHGTVKLRVEELQETYE 108

                        90       100
                ....*....|....*....|....*.
gi 30410765 187 AACLLQLDGLIQQCGETMKETVNVKT 212
Cdd:cd18272 109 VADMYQLTALFEECSRFLARTVQVRN 134

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 108 SDIKICALGEEWSLHKIYLCQSG-YFSSMFSGSWKESSMNIIELeipdQNIDVEALQVAFGSLYRDDVLIKPSRVVAILA 186
Cdd:cd18268  24 TDVILCTGDKEIPCHRNVLASSSpYFRAMFCNNFRESSQAKVDL----KGIDSDVLDQIVDYVYTGEILITRDNVLPLME 99

                        90       100
                ....*....|....*....|...
gi 30410765 187 AACLLQLDGLIQQCGETMKETVN 209
Cdd:cd18268 100 AASMLQYPKLFEACSLYLQDQLT 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765  88 KKLKSTSKYIYQTLFLNGENSDIKICALGEEWSLHKIYLCQ-SGYFSSMFSGSWKESSMNiiELEIPDQNIDVEALQVAF 166
Cdd:cd18237   2 AKLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAaSHFFHLMFTSNMTESKSS--EVELKDAEPDIIELLVEF 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 30410765 167 GslYRDDVLIKPSRVVAILAAACLLQLDGLIQQCGETMKETVN 209
Cdd:cd18237  80 A--YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 101 LFLNGENSDIKICALGEEWSLHKIYLC-QSGYFSSMFSGSWKESSMNIIEleIPDQNIDVEALQVAFgsLYR---DDVLI 176
Cdd:cd18297   6 YVNNPEMSDVTFLVEGRPFYAHKIVLVtASDRFKSMLSSGSTEAQTPVIE--IPDIRYDIFQLMMQY--LYTggvESLDV 81

                        90       100       110
                ....*....|....*....|....*....|....
gi 30410765 177 KPSRVVAILAAACLLQLDGLIQQCGETMKETVNV 210
Cdd:cd18297  82 AQDDALELLRAASFFQLDGLKRHCEILLSQQIDL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 122 HKIYLCQ-SGYFSSMFSGSWKESSMNIIELeipdQNIDVEALQVAFGSLYRDDVLIKPSRVVAILAAACLLQLDGLIQQC 200
Cdd:cd18257  33 HKVVLAScSPYFKAMFTGNLSEKENSEVEF----QCIDETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVLKEC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 117 EEWSLHKIYLCQ-SGYFSSMFSGSWKESSMNIIELEipDQNIDVEALQVAFGslYRDDVLIKPSRVVAILAAACLLQLDG 195
Cdd:cd18248  35 EEFMAHKVVLASsSPYFKAMFTSGLRECGMEVVPIE--GVHPCVMSRLIEFA--YTASISVGEKCVLHVLPGAVMYQMDS 110

                ....*
gi 30410765 196 LIQQC 200
Cdd:cd18248 111 VVKAC 115

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 108 SDIKI-CALGEEWSLHKIYLC-QSGYFSSMFSGSWKE-SSMNIIELEIPDQnidveALQVAFGSLYRDDVL-IKPSRVVA 183
Cdd:cd18302   6 YDVTIvSEDGKEFPCHKCVLVaRLEYFHSMLSSSWIEaSSCSALTMPIPSD-----ILEIILDYLYTDEASaVKESQNVE 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 30410765 184 ----ILAAACLLQLDGLIQQCGETMKETVNVK 211
Cdd:cd18302  81 flcnVLVIADQLLITRLKEICEVALVELLSLK 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 109 DIKICALGEEWSLHKIYLCQ-SGYFSSMFSGSWKESSMNIIELeipdQNIDVEALQVAFGSLYRDDVLIKPSRVVAILAA 187
Cdd:cd18338  23 DVTIVAEDVEIAAHRVVLAAcSPYFHAMFTGEMSESRAKRVRI----KEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPA 98

                        90
                ....*....|....*
gi 30410765 188 ACLLQLDGLIQQCGE 202
Cdd:cd18338  99 AGLLQLQDVKKTCCE 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 106 ENSDIKICALGEEWSLHKIYLCQ-SGYFSSMFSGSWKESSMNIIELeipdQNIDVEALQVAFGSLYRDDVLIKPSRVVAI 184
Cdd:cd18276  20 ELTDVVLVAEGEKFPCHRLVLAAfSPYFKAMFTCGLMECSQREVVL----HDITAESVSIILNYMYSSDLHLTNSNVQGV 95

                        90       100
                ....*....|....*....|..
gi 30410765 185 LAAACLLQLDGLIQQCGETMKE 206
Cdd:cd18276  96 ATAAFFLQMEDIFSVCQKYMMD 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 109 DIKICALGEEWSLHKIYLCQS-GYFSSMFSGSWKESSmniiELEIPDQNIDVEALQVAFGSLYRDDVLIKPSRVVAILAA 187
Cdd:cd18251  25 DVVLVVEGKPIEAHRILLAAScDYFRGMFAGGLREMQ----QTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTA 100

                        90
                ....*....|...
gi 30410765 188 ACLLQLDGLIQQC 200
Cdd:cd18251 101 ACQLQIPEVIGFC 113

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30410765 210 VKTVCGYYTSAGTYGLDSVKKKCLEWLLNNLMTHQNVELFKELSINVMKQLIGSSNLfvMQVEMDIYTALKKW 282
Cdd:cd18494   2 VETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKL--RIDELDILKAVREW 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 108 SDIKICALGEEWSLHKIYLCQ-SGYFSSMFSGswkESSMNIIELEIPdQNIDVEALQVAFGSLYRDDVLIKPSRVVAILA 186
Cdd:cd18332  20 TDVTLLVGGTPLRAHKAVLIAcSGFFYSIFSG---RVGEGVSVLTLP-SGLEARGFQLLLDFMYTSRLPLTPRTVPAVLA 95

                        90
                ....*....|....
gi 30410765 187 AACLLQLDGLIQQC 200
Cdd:cd18332  96 AATYLQMEHVVETC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30410765 109 DIKICALGEEWSLHKIYLCQ-SGYFSSMFSGSWKESSMNIIELeipdQNIDVEALQVAFGSLYRDDVLIKPSRVVAILAA 187
Cdd:cd18261  30 DITLVAEEQKFHAHKAVLAAcSDYFRAMFSLCMVESEADEVNL----HGVTSLGLKQALDFAYTGQILLEPGVIQDVLAA 105