PP2C family serine/threonine-protein phosphatase catalyzes the dephosphorylation of phosphoserine and phosphothreonine residues of specific protein substrates; contains a C-terminal PP2C domain that does not seem to play a role in catalysis, but may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
23-291
1.85e-102
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.
:
Pssm-ID: 238083 [Multi-domain] Cd Length: 254 Bit Score: 300.78 E-value: 1.85e-102
Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is ...
285-317
2.05e-16
Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteriztic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices, one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain.
The actual alignment was detected with superfamily member pfam07830:
Pssm-ID: 429684 Cd Length: 79 Bit Score: 72.93 E-value: 2.05e-16
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
23-291
1.85e-102
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.
Pssm-ID: 238083 [Multi-domain] Cd Length: 254 Bit Score: 300.78 E-value: 1.85e-102
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
17-289
3.01e-100
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.
Pssm-ID: 214625 [Multi-domain] Cd Length: 252 Bit Score: 295.05 E-value: 3.01e-100
Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is ...
285-317
2.05e-16
Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteriztic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices, one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain.
Pssm-ID: 429684 Cd Length: 79 Bit Score: 72.93 E-value: 2.05e-16
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
23-291
1.85e-102
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.
Pssm-ID: 238083 [Multi-domain] Cd Length: 254 Bit Score: 300.78 E-value: 1.85e-102
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
17-289
3.01e-100
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.
Pssm-ID: 214625 [Multi-domain] Cd Length: 252 Bit Score: 295.05 E-value: 3.01e-100
Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is ...
285-317
2.05e-16
Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteriztic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices, one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain.
Pssm-ID: 429684 Cd Length: 79 Bit Score: 72.93 E-value: 2.05e-16
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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