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Conserved domains on  [gi|29244256|ref|NP_808423|]
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kelch-like protein 38 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 11-139 6.74e-74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18268:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 129  Bit Score: 231.60  E-value: 6.74e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVIT 90
Cdd:cd18268   1 FKDQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 29244256  91 YVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18268  81 YVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 131-229 1.64e-53

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


:

Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 177.24  E-value: 1.64e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGEEEKVFEALMAWVKHDLQA 210
Cdd:cd18476   1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDELCGEEEQVFETLMVWIRHDPKA 80

                        90
                ....*....|....*....
gi 29244256 211 RWRHMQELLQQVRLQYIHP 229
Cdd:cd18476  81 RKGYIHDLFKKVRLQYVHP 99
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
310-571 1.23e-36

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 137.59  E-value: 1.23e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 310 GQWQSLAKLPIRLYKASAVTLHRSVYVLGGMtvSEGKSLIScgVYIFSLKLNQWRVGEPMLAARYSHRST-THRNFIFSI 388
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGL--SGGSASNS--FEVYDPATNTWSELAPLPGPPRHHAAAvAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 389 GGTGEGQ---ELLASMERYDSIRDVWESMAGMPVAVLHPAVAVKDQRLYLFGGEDiMQNPVRLIQVYHISRNTWykmetR 465
Cdd:COG3055  77 GGFTGANpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWD-DGGNVAWVEVYDPATGTW-----T 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 466 MIKNVCAP-----AVVLGE-QIVIVGGYTrrilaYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDcNIEd 539
Cdd:COG3055 151 QLAPLPTPrdhlaAAVLPDgKILVIGGRN-----GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD-EVE- 223

                       250       260       270
                ....*....|....*....|....*....|..
gi 29244256 540 sasfdCYDPETDTWTSQGQLPHKLFDHACLTL 571
Cdd:COG3055 224 -----AYDPATNTWTALGELPTPRHGHAAVLT 250
Kelch_6 pfam13964
Kelch motif;
281-321 1.67e-03

Kelch motif;


:

Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 1.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 29244256   281 SYQDFLLLLGGRKDNQQTTRDVLLYSGQTGQWQSLAKLPIR 321
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTP 49
 
Name Accession Description Interval E-value
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-139 6.74e-74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 231.60  E-value: 6.74e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVIT 90
Cdd:cd18268   1 FKDQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 29244256  91 YVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18268  81 YVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 131-229 1.64e-53

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 177.24  E-value: 1.64e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGEEEKVFEALMAWVKHDLQA 210
Cdd:cd18476   1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDELCGEEEQVFETLMVWIRHDPKA 80

                        90
                ....*....|....*....
gi 29244256 211 RWRHMQELLQQVRLQYIHP 229
Cdd:cd18476  81 RKGYIHDLFKKVRLQYVHP 99
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
310-571 1.23e-36

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 137.59  E-value: 1.23e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 310 GQWQSLAKLPIRLYKASAVTLHRSVYVLGGMtvSEGKSLIScgVYIFSLKLNQWRVGEPMLAARYSHRST-THRNFIFSI 388
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGL--SGGSASNS--FEVYDPATNTWSELAPLPGPPRHHAAAvAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 389 GGTGEGQ---ELLASMERYDSIRDVWESMAGMPVAVLHPAVAVKDQRLYLFGGEDiMQNPVRLIQVYHISRNTWykmetR 465
Cdd:COG3055  77 GGFTGANpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWD-DGGNVAWVEVYDPATGTW-----T 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 466 MIKNVCAP-----AVVLGE-QIVIVGGYTrrilaYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDcNIEd 539
Cdd:COG3055 151 QLAPLPTPrdhlaAAVLPDgKILVIGGRN-----GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD-EVE- 223

                       250       260       270
                ....*....|....*....|....*....|..
gi 29244256 540 sasfdCYDPETDTWTSQGQLPHKLFDHACLTL 571
Cdd:COG3055 224 -----AYDPATNTWTALGELPTPRHGHAAVLT 250
PHA03098 PHA03098
kelch-like protein; Provisional
 48-560 1.17e-30

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 126.04  E-value: 1.17e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   48 HRSVLASSSPYFKAMFCSHFRESrEAKVQmkgISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:PHA03098  26 HKIILSSSSEYFKKMFKNNFKEN-EINLN---IDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  128 QSQLAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKH 206
Cdd:PHA03098 102 IKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLnVSSEDVVLEIIIKWLTS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  207 DLQARWRHMQELLQQVRLQYIHPAFFH-------HFIANDALLQSSPACQaileMARKQIFSLYGpsaqdckllwrMPPR 279
Cdd:PHA03098 182 KKNNKYKDICLILKVLRITFLSEEGIKklkrwklRIKKKKIVFNKRCIKI----IYSKKYNLNKI-----------LPRS 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  280 SSYQDFLLLLGGrkdNQQTTRDVLLYSGQTGQWQSLAKLPIRlYKASAVTLHRSVYVLGGMtvsEGKSLISCGVYIFSLK 359
Cdd:PHA03098 247 STFGSIIYIHIT---MSIFTYNYITNYSPLSEINTIIDIHYV-YCFGSVVLNNVIYFIGGM---NKNNLSVNSVVSYDTK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  360 LNQWRVGEPMLAARYSHRSTTHRNFIFSIGGTGEGqELLASMERYDSIRDVWESMAGMPVAVLHPAVAVKDQRLYLFGGE 439
Cdd:PHA03098 320 TKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNS-ISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGI 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  440 DIMQNPVRLIQVYHISRNTWYKMETRMIKNVCAPAVVLGEQIVIVGGYT--------RRILAYDPQSNKFVKCADMKDRR 511
Cdd:PHA03098 399 SKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISyidnikvyNIVESYNPVTNKWTELSSLNFPR 478

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 29244256  512 MHHGATVMGNKLYVTGGrrlttDCNIEDSASFDCYDPETDTWTSQGQLP 560
Cdd:PHA03098 479 INASLCIFNNKIYVVGG-----DKYEYYINEIEVYDDKTNTWTLFCKFP 522
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 136-237 2.29e-30

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 114.56  E-value: 2.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   136 CLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLC-GEEEKVFEALMAWVKHDLQARWRH 214
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 29244256   215 MQELLQQVRLQYIHPAFFHHFIA 237
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 136-234 4.44e-28

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 107.81  E-value: 4.44e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256    136 CLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLC-GEEEKVFEALMAWVKHDLQARWRH 214
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 29244256    215 MQELLQQVRLQYIHPAFFHH 234
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 24-131 6.98e-25

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 99.25  E-value: 6.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256    24 LNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVhISAAN 103
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 29244256   104 VLPLMEAAAMLQYPRVFEACSSYLQSQL 131
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 35-131 2.56e-21

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 88.90  E-value: 2.56e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256     35 DVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAML 114
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 29244256    115 QYPRVFEACSSYLQSQL 131
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
Kelch smart00612
Kelch domain;
480-521 2.66e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 50.25  E-value: 2.66e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 29244256    480 QIVIVGGY-----TRRILAYDPQSNKFVKCADMKDRRMHHGATVMGN 521
Cdd:smart00612   1 KIYVVGGFdggqrLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 510-560 3.53e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.53  E-value: 3.53e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 29244256   510 RRMHHGATVMGNKLYVTGGRRLTTDCNiedsaSFDCYDPETDTWTSQGQLP 560
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLN-----SVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
281-321 1.67e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 1.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 29244256   281 SYQDFLLLLGGRKDNQQTTRDVLLYSGQTGQWQSLAKLPIR 321
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTP 49
 
Name Accession Description Interval E-value
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-139 6.74e-74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 231.60  E-value: 6.74e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVIT 90
Cdd:cd18268   1 FKDQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 29244256  91 YVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18268  81 YVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 131-229 1.64e-53

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 177.24  E-value: 1.64e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGEEEKVFEALMAWVKHDLQA 210
Cdd:cd18476   1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDELCGEEEQVFETLMVWIRHDPKA 80

                        90
                ....*....|....*....
gi 29244256 211 RWRHMQELLQQVRLQYIHP 229
Cdd:cd18476  81 RKGYIHDLFKKVRLQYVHP 99
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
310-571 1.23e-36

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 137.59  E-value: 1.23e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 310 GQWQSLAKLPIRLYKASAVTLHRSVYVLGGMtvSEGKSLIScgVYIFSLKLNQWRVGEPMLAARYSHRST-THRNFIFSI 388
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGL--SGGSASNS--FEVYDPATNTWSELAPLPGPPRHHAAAvAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 389 GGTGEGQ---ELLASMERYDSIRDVWESMAGMPVAVLHPAVAVKDQRLYLFGGEDiMQNPVRLIQVYHISRNTWykmetR 465
Cdd:COG3055  77 GGFTGANpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWD-DGGNVAWVEVYDPATGTW-----T 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 466 MIKNVCAP-----AVVLGE-QIVIVGGYTrrilaYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDcNIEd 539
Cdd:COG3055 151 QLAPLPTPrdhlaAAVLPDgKILVIGGRN-----GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD-EVE- 223

                       250       260       270
                ....*....|....*....|....*....|..
gi 29244256 540 sasfdCYDPETDTWTSQGQLPHKLFDHACLTL 571
Cdd:COG3055 224 -----AYDPATNTWTALGELPTPRHGHAAVLT 250
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
287-528 1.73e-36

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 137.21  E-value: 1.73e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 287 LLLGGRKDNQQTTRDVLLYSGQTGQWQSLAKLPI-RLYKASAVTLHRSVYVLGGMTVSEGKSLISCGVYIFSLKLNQWRV 365
Cdd:COG3055  25 VYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFTGANPSSTPLNDVYVYDPATNTWTK 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 366 GEPMLAARYSHRSTTHRNFIFSIGGTGEGQElLASMERYDSIRDVWESMAGMPVAVLHPAVAV-KDQRLYLFGGEDimqn 444
Cdd:COG3055 105 LAPMPTPRGGATALLLDGKIYVVGGWDDGGN-VAWVEVYDPATGTWTQLAPLPTPRDHLAAAVlPDGKILVIGGRN---- 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 445 pvrliqvYHISRNTWYKMETRMIKNVCAPAVVLGEQIVIVGGYTR---RILAYDPQSNKFVKCADMKDRRMHHGATVMGN 521
Cdd:COG3055 180 -------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGfsdEVEAYDPATNTWTALGELPTPRHGHAAVLTDG 252


                ....*..
gi 29244256 522 KLYVTGG 528
Cdd:COG3055 253 KVYVIGG 259
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-136 2.35e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 131.81  E-value: 2.35e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  13 DHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYV 92
Cdd:cd18250   1 DPAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 29244256  93 YTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNC 136
Cdd:cd18250  81 YTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-136 4.88e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 130.73  E-value: 4.88e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGE 96
Cdd:cd18253   2 SESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGK 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 29244256  97 VHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNC 136
Cdd:cd18253  82 VKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-138 1.76e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 126.64  E-value: 1.76e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  19 DLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVH 98
Cdd:cd18238   1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLT 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 29244256  99 ISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLG 138
Cdd:cd18238  81 LTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-138 1.04e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 124.58  E-value: 1.04e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVIT 90
Cdd:cd18236   2 FDDTGLSLVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLD 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 29244256  91 YVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLG 138
Cdd:cd18236  82 YTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 2.30e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 120.61  E-value: 2.30e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  14 HSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVY 93
Cdd:cd18235   2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 29244256  94 TGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAP 133
Cdd:cd18235  82 TAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-136 4.40e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 119.85  E-value: 4.40e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18242   3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYT 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNC 136
Cdd:cd18242  83 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-138 8.84e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 119.55  E-value: 8.84e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18259  14 SHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYT 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLG 138
Cdd:cd18259  94 GKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-138 2.20e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 118.28  E-value: 2.20e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18256   7 ILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEV 86

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLG 138
Cdd:cd18256  87 TVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125
PHA03098 PHA03098
kelch-like protein; Provisional
 48-560 1.17e-30

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 126.04  E-value: 1.17e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   48 HRSVLASSSPYFKAMFCSHFRESrEAKVQmkgISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:PHA03098  26 HKIILSSSSEYFKKMFKNNFKEN-EINLN---IDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  128 QSQLAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKH 206
Cdd:PHA03098 102 IKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLnVSSEDVVLEIIIKWLTS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  207 DLQARWRHMQELLQQVRLQYIHPAFFH-------HFIANDALLQSSPACQaileMARKQIFSLYGpsaqdckllwrMPPR 279
Cdd:PHA03098 182 KKNNKYKDICLILKVLRITFLSEEGIKklkrwklRIKKKKIVFNKRCIKI----IYSKKYNLNKI-----------LPRS 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  280 SSYQDFLLLLGGrkdNQQTTRDVLLYSGQTGQWQSLAKLPIRlYKASAVTLHRSVYVLGGMtvsEGKSLISCGVYIFSLK 359
Cdd:PHA03098 247 STFGSIIYIHIT---MSIFTYNYITNYSPLSEINTIIDIHYV-YCFGSVVLNNVIYFIGGM---NKNNLSVNSVVSYDTK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  360 LNQWRVGEPMLAARYSHRSTTHRNFIFSIGGTGEGqELLASMERYDSIRDVWESMAGMPVAVLHPAVAVKDQRLYLFGGE 439
Cdd:PHA03098 320 TKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNS-ISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGI 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  440 DIMQNPVRLIQVYHISRNTWYKMETRMIKNVCAPAVVLGEQIVIVGGYT--------RRILAYDPQSNKFVKCADMKDRR 511
Cdd:PHA03098 399 SKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISyidnikvyNIVESYNPVTNKWTELSSLNFPR 478

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 29244256  512 MHHGATVMGNKLYVTGGrrlttDCNIEDSASFDCYDPETDTWTSQGQLP 560
Cdd:PHA03098 479 INASLCIFNNKIYVVGG-----DKYEYYINEIEVYDDKTNTWTLFCKFP 522
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 136-237 2.29e-30

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 114.56  E-value: 2.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   136 CLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLC-GEEEKVFEALMAWVKHDLQARWRH 214
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 29244256   215 MQELLQQVRLQYIHPAFFHHFIA 237
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-138 2.82e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 115.25  E-value: 2.82e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18265  10 ILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRI 89

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLG 138
Cdd:cd18265  90 QEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-138 3.97e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 114.51  E-value: 3.97e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  18 SDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEV 97
Cdd:cd18237   6 ADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARI 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 29244256  98 HISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLG 138
Cdd:cd18237  86 SVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-139 9.90e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 114.32  E-value: 9.90e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  10 VFKDHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMK-GISSTTLEQV 88
Cdd:cd18267  17 LFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHdSIHPEVLELL 96

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 29244256  89 ITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18267  97 LDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-141 2.51e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 113.00  E-value: 2.51e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  10 VFKDHSFSSDLLRQLNGLRQSKILTDVSI--------CSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGIS 81
Cdd:cd18273   3 ELEDAAHARALLAQLKSFYDARLLTDVTIevngpgsgPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVD 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  82 STTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGLVR 141
Cdd:cd18273  83 SESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGILK 142
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-137 3.21e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 111.30  E-value: 3.21e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  33 LTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAA 112
Cdd:cd18234   1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                        90       100
                ....*....|....*....|....*
gi 29244256 113 MLQYPRVFEACSSYLQSQLAPSNCL 137
Cdd:cd18234  81 LLQLSEVVEACCGFLMKQLHPSNCL 105
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 136-234 4.44e-28

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 107.81  E-value: 4.44e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256    136 CLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLC-GEEEKVFEALMAWVKHDLQARWRH 214
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 29244256    215 MQELLQQVRLQYIHPAFFHH 234
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-114 1.88e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 105.71  E-value: 1.88e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  33 LTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAA 112
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                ..
gi 29244256 113 ML 114
Cdd:cd18186  81 KL 82
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-136 2.23e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 106.71  E-value: 2.23e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGE 96
Cdd:cd18255   2 SVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSE 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 29244256  97 VHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNC 136
Cdd:cd18255  82 LTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-138 3.05e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 106.63  E-value: 3.05e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMK-GISSTTLEQVITYVY 93
Cdd:cd18254   4 SHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHdSLHPEVLELLLDFAY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 29244256  94 TGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLG 138
Cdd:cd18254  84 SSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-133 1.13e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 104.77  E-value: 1.13e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  21 LRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHIS 100
Cdd:cd18338   9 FKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVT 88

                        90       100       110
                ....*....|....*....|....*....|...
gi 29244256 101 AANVLPLMEAAAMLQYPRVFEACSSYLQSQLAP 133
Cdd:cd18338  89 EENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-131 1.67e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 104.38  E-value: 1.67e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSI----CSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVIT 90
Cdd:cd18248   3 DHTKEAFQIMNELRLSQQLCDVTLkvkyQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIE 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 29244256  91 YVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQL 131
Cdd:cd18248  83 FAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-133 2.19e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 104.03  E-value: 2.19e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  24 LNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAAN 103
Cdd:cd18339  12 MNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEEN 91

                        90       100       110
                ....*....|....*....|....*....|
gi 29244256 104 VLPLMEAAAMLQYPRVFEACSSYLQSQLAP 133
Cdd:cd18339  92 VQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-133 2.24e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 103.77  E-value: 2.24e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTG 95
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 29244256  96 EVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAP 133
Cdd:cd18257  81 TVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-139 4.10e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 103.11  E-value: 4.10e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTG 95
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 29244256  96 EVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18306  81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-140 1.92e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 101.62  E-value: 1.92e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTG 95
Cdd:cd18270   9 YAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTG 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 29244256  96 EVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGLV 140
Cdd:cd18270  89 NLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-139 1.99e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 101.71  E-value: 1.99e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQ-LNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18269   9 YQQTLLQDgLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYT 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18269  89 SEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-130 2.83e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 100.43  E-value: 2.83e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18247   1 DLPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYS 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQ 130
Cdd:cd18247  81 GRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-139 2.94e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 100.89  E-value: 2.94e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  21 LRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHIS 100
Cdd:cd18336   7 FRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELK 86

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 29244256 101 AANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18336  87 EDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 133-231 5.81e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 99.41  E-value: 5.81e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 133 PSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCG-EEEKVFEALMAWVKHDLQAR 211
Cdd:cd18468   2 PSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTkAEELVFETAIKWLKKDPKNR 81

                        90       100
                ....*....|....*....|
gi 29244256 212 WRHMQELLQQVRLQYIHPAF 231
Cdd:cd18468  82 KQHIAELLAVVRLPFIHPSY 101
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-136 6.34e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 99.71  E-value: 6.34e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  24 LNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAAN 103
Cdd:cd18240   8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAEN 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 29244256 104 VLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNC 136
Cdd:cd18240  88 VEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 24-131 6.98e-25

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 99.25  E-value: 6.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256    24 LNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVhISAAN 103
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 29244256   104 VLPLMEAAAMLQYPRVFEACSSYLQSQL 131
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-139 9.06e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 99.91  E-value: 9.06e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  44 EVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEAC 123
Cdd:cd18340  38 EFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVC 117

                        90
                ....*....|....*.
gi 29244256 124 SSYLQSQLAPSNCLGL 139
Cdd:cd18340 118 VSFLQKRLCLSNCLAI 133
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-138 3.56e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 97.91  E-value: 3.56e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  19 DLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVH 98
Cdd:cd18249   9 QTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQIT 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 29244256  99 ISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLG 138
Cdd:cd18249  89 VEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-139 5.01e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 97.57  E-value: 5.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18276   8 LLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHL 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18276  88 TNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-138 1.29e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 96.43  E-value: 1.29e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  13 DHSFSSDLLRQLNGLRQSKILTDVSICSGAWEV-PCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITY 91
Cdd:cd18252   1 DSSHPADFLDAFRTFYLDGLFTDITLQCASGQIfHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNY 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 29244256  92 VYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLG 138
Cdd:cd18252  81 VYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-139 2.45e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 95.44  E-value: 2.45e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  13 DHSFSSDLLRQLNGLRQSKILTDVSI-CSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITY 91
Cdd:cd18274   2 DPLHACSILQQLKAMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 29244256  92 VYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18274  82 AYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-139 2.96e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 92.43  E-value: 2.96e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVIT 90
Cdd:cd18337   1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 29244256  91 YVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18337  81 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-136 3.42e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 92.55  E-value: 3.42e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18264  15 VLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSL 94

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNC 136
Cdd:cd18264  95 SLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-139 1.19e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 91.06  E-value: 1.19e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQ-LNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18341   9 YQSTLLQDgLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYS 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18341  89 AEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 1.80e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 90.47  E-value: 1.80e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  19 DLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVH 98
Cdd:cd18246  25 DAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIV 104

                        90       100       110
                ....*....|....*....|....*....|....*
gi 29244256  99 ISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAP 133
Cdd:cd18246 105 VGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-138 2.44e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 89.65  E-value: 2.44e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  19 DLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAK---VQMKGISSTTLEQVITYVYTG 95
Cdd:cd18258   3 EMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEkleLTMSNINADVLELLLEFVYTG 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 29244256  96 EVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLG 138
Cdd:cd18258  83 SLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 35-131 2.56e-21

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 88.90  E-value: 2.56e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256     35 DVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAML 114
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 29244256    115 QYPRVFEACSSYLQSQL 131
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 130-231 6.68e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 87.77  E-value: 6.68e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 130 QLAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDL 208
Cdd:cd18444   1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLnVPSEETIFHALLLWVKHDL 80

                        90       100
                ....*....|....*....|...
gi 29244256 209 QARWRHMQELLQQVRLQYIHPAF 231
Cdd:cd18444  81 PERKKHLAKLLALIRLPLLTPQF 103
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-143 1.48e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 88.02  E-value: 1.48e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  13 DHSfsSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYV 92
Cdd:cd18266   7 DHS--NLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFL 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 29244256  93 YTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGLVRLA 143
Cdd:cd18266  85 YSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-136 2.90e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 86.78  E-value: 2.90e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSFSSDLLRQLNGLRQSKILTDVSICSGAWE--VPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQV 88
Cdd:cd18239   1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDetFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNI 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 29244256  89 ITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNC 136
Cdd:cd18239  81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 131-257 3.72e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 86.68  E-value: 3.72e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQ 209
Cdd:cd18452   1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIqVDSEEPVFEAVLNWVKHDKE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 29244256 210 ARWRHMQELLQQVRLQYIHPAFFHHFIANDALLQSSPACQAILEMARK 257
Cdd:cd18452  81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKK 128
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-137 4.16e-20

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 86.02  E-value: 4.16e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  21 LRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHIS 100
Cdd:cd18263   1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLS 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 29244256 101 AANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCL 137
Cdd:cd18263  81 WENLFEATCTALQLQISGALALCLDFLQREISPARCL 117
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 131-243 5.63e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 85.36  E-value: 5.63e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQ 209
Cdd:cd18445   1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLtVPSEEKVFEAVMSWVNHDPE 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 29244256 210 ARWRHMQELLQQVRLQYIHPAFFHHFIANDALLQ 243
Cdd:cd18445  81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-139 6.29e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 86.04  E-value: 6.29e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18271  11 ILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEI 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18271  91 TDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 131-257 6.37e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 85.89  E-value: 6.37e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQ 209
Cdd:cd18513   1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLtVSSEEKVFEAVISWIKYDKE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 29244256 210 ARWRHMQELLQQVRLQYIHPAFFHHFIANDALLQSSPACQAILEMARK 257
Cdd:cd18513  81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMK 128
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-139 9.61e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 85.48  E-value: 9.61e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  21 LRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHIS 100
Cdd:cd18335   7 FRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELK 86

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 29244256 101 AANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGL 139
Cdd:cd18335  87 EDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 131-257 1.48e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 85.08  E-value: 1.48e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLC-GEEEKVFEALMAWVKHDLQ 209
Cdd:cd18512   1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTiSSEEKVFEAVIAWVNHDKE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 29244256 210 ARWRHMQELLQQVRLQYIHPAFFHHFIANDALLQSSPACQAILEMARK 257
Cdd:cd18512  81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMK 128
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-136 2.40e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 84.52  E-value: 2.40e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSFSSDLLRQLNGLRQSKILTDVSIC---SGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISST---- 83
Cdd:cd18241   1 FECSSHCSELSWRQNEQRKQGLFCDITLAfggAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEpgpd 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 29244256  84 --TLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNC 136
Cdd:cd18241  81 pdTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 130-206 3.04e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 82.06  E-value: 3.04e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29244256 130 QLAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKH 206
Cdd:cd18463   1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELvVPKEEEVFEAVMRWVYH 78
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
262-439 6.91e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.13  E-value: 6.91e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 262 LYGPSAQDCKLLWRMP-PRSS-----YQDFLLLLGGRKDNQqTTRDVLLYSGQTGQWQSLAKLPIRLYKASAVTL-HRSV 334
Cdd:COG3055  94 VYDPATNTWTKLAPMPtPRGGatallLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKI 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 335 YVLGGMTvsegksliscgvyiFSLKLNQWRVGEPMLAARYSHRSTTHRNFIFSIGGTGEgqeLLASMERYDSIRDVWESM 414
Cdd:COG3055 173 LVIGGRN--------------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG---FSDEVEAYDPATNTWTAL 235

                       170       180
                ....*....|....*....|....*
gi 29244256 415 AGMPVAVLHPAVAVKDQRLYLFGGE 439
Cdd:COG3055 236 GELPTPRHGHAAVLTDGKVYVIGGE 260
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-128 1.35e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 81.62  E-value: 1.35e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESRE--AKVQMKGISSTTLEQVITYVYTGEV 97
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGstYKIELEGISVEVMEEILDYIYTGQI 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 29244256  98 HISAANVLPLMEAAAMLQYPRVFEACSSYLQ 128
Cdd:cd18245  81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 131-231 1.92e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 80.81  E-value: 1.92e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQ 209
Cdd:cd18457   1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELnVKSEEQVFEAALAWVKYDRE 80

                        90       100
                ....*....|....*....|..
gi 29244256 210 ARWRHMQELLQQVRLQYIHPAF 231
Cdd:cd18457  81 NREEYLPELLSKVRLPLLRPQF 102
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 29-123 4.73e-18

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 79.31  E-value: 4.73e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  29 QSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLM 108
Cdd:cd18314   2 NDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLL 81

                        90
                ....*....|....*
gi 29244256 109 EAAAMLQYPRVFEAC 123
Cdd:cd18314  82 MLASKYQVPDLEKLC 96
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-128 3.52e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 77.60  E-value: 3.52e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   8 GVVFKDHSfsSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQ 87
Cdd:cd18198   2 GIPFPDHS--SEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTA 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 29244256  88 VITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQ 128
Cdd:cd18198  80 LLEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-135 3.85e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 77.94  E-value: 3.85e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGE 96
Cdd:cd18251   7 SQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSE 86

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 29244256  97 VHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSN 135
Cdd:cd18251  87 LELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-127 4.00e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 77.67  E-value: 4.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   8 GVVFKDHSfsSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQ 87
Cdd:cd18326   2 GIPFPDHS--SDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTA 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 29244256  88 VITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18326  80 LLDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 45-131 5.36e-17

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 76.89  E-value: 5.36e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  45 VPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAAN-VLPLMEAAAMLQYPRVFEAC 123
Cdd:cd18300  21 IPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGdCVGLIVLANRLCLPRLVALC 100


                ....*...
gi 29244256 124 SSYLQSQL 131
Cdd:cd18300 101 EQYIVKEL 108
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 33-115 1.37e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 74.89  E-value: 1.37e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  33 LTDVSICSGAWEVPCHRSVLASSSPYFKAMFCShFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAA 112
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKE-TPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                ...
gi 29244256 113 MLQ 115
Cdd:cd18315  80 LLQ 82
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 130-232 1.54e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 75.49  E-value: 1.54e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 130 QLAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLG-DDRLCGEEEKVFEALMAWVKHDL 208
Cdd:cd18511   1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLAsDDMNIPNEETILNALLSWVRHDV 80

                        90       100
                ....*....|....*....|....
gi 29244256 209 QARWRHMQELLQQVRLQYIHPAFF 232
Cdd:cd18511  81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 130-229 5.22e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 73.80  E-value: 5.22e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 130 QLAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLG-DDRLCGEEEKVFEALMAWVKHDL 208
Cdd:cd18510   1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLAsDDINVPDEETIFQALMMWVRHDL 80

                        90       100
                ....*....|....*....|.
gi 29244256 209 QARWRHMQELLQQVRLQYIHP 229
Cdd:cd18510  81 QNRQKDLGMLLSYIRLPLLPP 101
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 131-227 5.30e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 73.68  E-value: 5.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLC-GEEEKVFEALMAWVKHDLQ 209
Cdd:cd18460   1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCvDKEETAYQIALRWVKADPK 80

                        90
                ....*....|....*...
gi 29244256 210 ARWRHMQELLQQVRLQYI 227
Cdd:cd18460  81 HRQHFWPELLQHVRLPFV 98
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-128 6.26e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 74.50  E-value: 6.26e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   8 GVVFKDHSfsSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKV-------QMKGI 80
Cdd:cd18327   2 GIPFPEHS--SELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqdvcELDFV 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 29244256  81 SSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQ 128
Cdd:cd18327  80 GPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 131-224 1.03e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 73.06  E-value: 1.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQ 209
Cdd:cd18467   1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLnVVTEETVFYALESWIKYDVQ 80

                        90
                ....*....|....*
gi 29244256 210 ARWRHMQELLQQVRL 224
Cdd:cd18467  81 ERQKYLAQLLHCVRL 95
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 130-219 1.11e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 72.33  E-value: 1.11e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 130 QLAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDL 208
Cdd:cd18458   1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELnVRCESEVYNAVIRWVKYDE 80

                        90
                ....*....|.
gi 29244256 209 QARWRHMQELL 219
Cdd:cd18458  81 ENRRQYLEALL 91
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-131 1.45e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 73.17  E-value: 1.45e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKV-QMKGISSTTLEQVITYVYTGEVH 98
Cdd:cd18230   8 LLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVtHLDIVTAQGFKAIIDFMYSAHLA 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 29244256  99 ISAANVLPLMEAAAMLQYPRVFEACSSYLQSQL 131
Cdd:cd18230  88 LTSKNVIEVMSAASYLQMTDIVQACHNFIKAAL 120
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-137 1.79e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 73.46  E-value: 1.79e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18261  10 SHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYT 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCL 137
Cdd:cd18261  90 GQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 130-225 2.28e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 71.95  E-value: 2.28e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 130 QLAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGE-EEKVFEALMAWVKHDL 208
Cdd:cd18448   1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVEsESQVYEAVMKWVKHDP 80

                        90
                ....*....|....*..
gi 29244256 209 QARWRHMQELLQQVRLQ 225
Cdd:cd18448  81 QHRKRHLDDLLSQVRLP 97
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-137 2.75e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 72.15  E-value: 2.75e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFcshFRESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18260   5 LLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNIL---KKDPSLQRVELNDISPLGLATVITYAYTGKLTL 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCL 137
Cdd:cd18260  82 SLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-137 4.87e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 72.23  E-value: 4.87e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   8 GVVFKDHSFSSDLLRQLNGL-RQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLE 86
Cdd:cd18272   6 SYTFTDRSHSSRVAQSIMDLcLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQ 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 29244256  87 QVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCL 137
Cdd:cd18272  86 LLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCL 136
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 131-207 5.43e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 69.95  E-value: 5.43e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAA-SADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHD 207
Cdd:cd18450   1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELnVKEEEVVFEAIVKWIDHD 79
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-136 7.16e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 71.53  E-value: 7.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  27 LRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLP 106
Cdd:cd18244  24 LYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHE 103

                        90       100       110
                ....*....|....*....|....*....|
gi 29244256 107 LMEAAAMLQYPRVFEACSSYLQSQLAPSNC 136
Cdd:cd18244 104 ILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 36-114 1.50e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 68.85  E-value: 1.50e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29244256  36 VSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAML 114
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 130-224 1.77e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 69.38  E-value: 1.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 130 QLAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDL 208
Cdd:cd18459   1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELnVRSEEQVFNAVMAWVKYNI 80

                        90
                ....*....|....*.
gi 29244256 209 QARWRHMQELLQQVRL 224
Cdd:cd18459  81 QERRPHLPQVLQHVRL 96
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 131-232 3.15e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 69.03  E-value: 3.15e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQ 209
Cdd:cd18446   1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLyVTEEEQVFETVMRWVRYKES 80

                        90       100
                ....*....|....*....|...
gi 29244256 210 ARWRHMQELLQQVRLQYIHPAFF 232
Cdd:cd18446  81 ERLPLLPRVLENVRLPLLDPWYF 103
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 25-131 3.42e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 69.25  E-value: 3.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  25 NGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREA-----KVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18296   9 FPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDL 88

                        90       100       110
                ....*....|....*....|....*....|..
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACSSYLQSQL 131
Cdd:cd18296  89 PPENAYDVLYVADMYLLPGLKRLCGTVLAQSL 120
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-127 4.10e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 68.80  E-value: 4.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  13 DHSfsSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYV 92
Cdd:cd18287   4 DHV--HFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYI 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 29244256  93 YTGEVHISA---ANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18287  82 YTGRLTLTDlkeDVLLDVLGLAHQYGFEELEAAISDYL 119
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 131-229 4.78e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 68.51  E-value: 4.78e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQ 209
Cdd:cd18509   2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVnVPDEETIFHALMMWVKYDMQ 81

                        90       100
                ....*....|....*....|
gi 29244256 210 ARWRHMQELLQQVRLQYIHP 229
Cdd:cd18509  82 RRCSDLSMLLAYIRLPLLPP 101
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 131-224 1.91e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 66.41  E-value: 1.91e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGE-EEKVFEALMAWVKHDLQ 209
Cdd:cd18514   1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEdEQVVFNAVLQWVKYDLE 80

                        90
                ....*....|....*
gi 29244256 210 ARWRHMQELLQQVRL 224
Cdd:cd18514  81 KRKDYLPELLRNVRL 95
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 131-225 1.94e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 66.40  E-value: 1.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGE-EEKVFEALMAWVKHDLQ 209
Cdd:cd18477   1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEkEEAVFEAVMKWVREAKE 80

                        90
                ....*....|....*.
gi 29244256 210 ARWRHMQELLQQVRLQ 225
Cdd:cd18477  81 NRQKALPTVFESIRFR 96
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-123 2.39e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 66.83  E-value: 2.39e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   8 GVVFKDHSfsSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQ 87
Cdd:cd18328   2 GIPFPNHS--SEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSA 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 29244256  88 VITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEAC 123
Cdd:cd18328  80 ILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVC 115
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 130-224 5.06e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 65.16  E-value: 5.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 130 QLAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDL 208
Cdd:cd18469   2 QIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLqVRDEQSRLEAVLRWVGHDP 81

                        90
                ....*....|....*.
gi 29244256 209 QARWRHMQELLQQVRL 224
Cdd:cd18469  82 QARAAHLPELLSLVHL 97
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 131-225 6.23e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 64.79  E-value: 6.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGE-EEKVFEALMAWVKHDLQ 209
Cdd:cd18517   1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEkEELVFEAVMKWVRTDKE 80

                        90
                ....*....|....*.
gi 29244256 210 ARWRHMQELLQQVRLQ 225
Cdd:cd18517  81 NRVKSLGEIFDCIRFR 96
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 133-224 7.19e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 64.61  E-value: 7.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 133 PSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGEEEK-VFEALMAWVKHDLQAR 211
Cdd:cd18515   2 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERlVYEAAINWVNYDLKKR 81

                        90
                ....*....|...
gi 29244256 212 WRHMQELLQQVRL 224
Cdd:cd18515  82 HCYLSELLQTVRL 94
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 131-231 1.17e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 64.25  E-value: 1.17e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQ 209
Cdd:cd18456   1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLnVPSEEEVYRAVLSWVKHDVD 80

                        90       100
                ....*....|....*....|..
gi 29244256 210 ARWRHMQELLQQVRLQYIHPAF 231
Cdd:cd18456  81 GRRQHVPRLMKCVRLPLLSRDF 102
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 131-204 1.34e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 63.18  E-value: 1.34e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLC-GEEEKVFEALMAWV 204
Cdd:cd18472   1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEvAEEEAVFEAAVRWL 75
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 133-224 3.01e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 62.90  E-value: 3.01e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 133 PSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGEEEK-VFEALMAWVKHDLQAR 211
Cdd:cd18464   2 PSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERlVYEAVIGWIRYDLPRR 81

                        90
                ....*....|...
gi 29244256 212 WRHMQELLQQVRL 224
Cdd:cd18464  82 HEVLPELLRSVRL 94
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-131 3.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 63.82  E-value: 3.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  13 DHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAK-------VQMKGISSttl 85
Cdd:cd18201   1 ENSYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTtvthldvVAVQGFSV--- 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 29244256  86 eqVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQL 131
Cdd:cd18201  78 --ILDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-140 3.38e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 62.89  E-value: 3.38e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  48 HRSVLASSSPYFKAmfcshfRESREAkVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18275  19 HKSVLAAKSDYFRA------RLSRDI-LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPCAAQCAVDAV 91

                        90
                ....*....|...
gi 29244256 128 QSQLAPSNCLGLV 140
Cdd:cd18275  92 RAQLCLGNCYEVL 104
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-131 3.90e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 63.34  E-value: 3.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSH-------FRESREAKVQMKGISSTTLEQ 87
Cdd:cd18228   1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQasprlvlVSPAGKCVLDLHHVTVTGFAP 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 29244256  88 VITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQL 131
Cdd:cd18228  81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-128 7.02e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 62.65  E-value: 7.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYfkamFCSHFRESREAKVQMKGI-SSTTLEQVITYVYT 94
Cdd:cd18227   8 FSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPY----FCDQVLLKNSRRIVLPDVmNPRVFENILLSCYT 83

                        90       100       110
                ....*....|....*....|....*....|....
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQ 128
Cdd:cd18227  84 GRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 131-227 1.03e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 61.31  E-value: 1.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGE-EEKVFEALMAWVKHDLQ 209
Cdd:cd18516   1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEkEEDVFEAVMKWVGKDQE 80

                        90
                ....*....|....*...
gi 29244256 210 ARWRHMQELLQQVRLQYI 227
Cdd:cd18516  81 ERTKALPVLLESIRFRLM 98
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 131-229 1.13e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 61.28  E-value: 1.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQ 209
Cdd:cd18485   1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLnVSREESILDLVLRWVNHNRK 80

                        90       100
                ....*....|....*....|
gi 29244256 210 ARWRHMQELLQQVRLQYIHP 229
Cdd:cd18485  81 SRVQHLVELLKQVRLELVSP 100
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-128 1.68e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 61.60  E-value: 1.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   4 ELPDgvvfkdhsFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKamfcSHFRESREAKVQMKGISS- 82
Cdd:cd18222   4 EIPD--------FSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFR----DHMSLNEMSTVSISVIKNp 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 29244256  83 TTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQ 128
Cdd:cd18222  72 TVFEQLLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILE 117
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 134-211 3.06e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 59.64  E-value: 3.06e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29244256 134 SNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQAR 211
Cdd:cd18480   4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELnVPDEEAVLKAVLRWTKHDLEAR 82
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-127 3.20e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 60.71  E-value: 3.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRES-REAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18330   1 YYTKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSgRHSTASLDIVTSEAFSIILDFLYS 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18330  81 GKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 132-225 3.44e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 60.02  E-value: 3.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 132 APSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQA 210
Cdd:cd18455   1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLnVGNEEYIFEAVLRWVRHDPEE 80

                        90
                ....*....|....*
gi 29244256 211 RWRHMQELLQQVRLQ 225
Cdd:cd18455  81 RKVHLKDLMSSCWRS 95
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-128 4.80e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 59.87  E-value: 4.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGE 96
Cdd:cd18332   3 SSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYTSR 82

                        90       100       110
                ....*....|....*....|....*....|..
gi 29244256  97 VHISAANVLPLMEAAAMLQYPRVFEACSSYLQ 128
Cdd:cd18332  83 LPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-125 4.87e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 60.23  E-value: 4.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  18 SDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVqMKGISSTTLEQVITYVYTGEV 97
Cdd:cd18224  11 NNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYV-VDFITPANFEKVLSFIYTSEL 89

                        90       100
                ....*....|....*....|....*...
gi 29244256  98 HISAANVLPLMEAAAMLQYPRVFEACSS 125
Cdd:cd18224  90 FTDLINVGVIYEVAEKLGMEDLLKACHS 117
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-135 5.71e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 60.44  E-value: 5.71e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  13 DHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHfresreaKVQMKGISSTTLEQVITYV 92
Cdd:cd18243  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN-------NLVLQGCSSIGLRLVLEYL 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 29244256  93 YTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSN 135
Cdd:cd18243  85 YTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-127 5.85e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 59.84  E-value: 5.85e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKV-QMKGISSTTLEQVITYVY 93
Cdd:cd18329   3 SHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVaTFDVFSPDTFTIILDFVY 82

                        90       100       110
                ....*....|....*....|....*....|....
gi 29244256  94 TGEVHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18329  83 SGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 134-207 6.71e-11

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 58.57  E-value: 6.71e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29244256 134 SNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHD 207
Cdd:cd18508   3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLnVPSEERVYEAAVAWLKHD 77
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-123 9.71e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 59.00  E-value: 9.71e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCShfRESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18217   5 LLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKD--TEDNIVFLDQSQVSADGFQKLLEFIYTGNLNL 82

                        90       100
                ....*....|....*....|....
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEAC 123
Cdd:cd18217  83 DSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-111 1.08e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 58.80  E-value: 1.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNglrqSKILTDVS--ICSGAWEVPCHRSVLASSSPYFKAMFCSHFR-ESREAKVQMKGISSTTLEQVITYV 92
Cdd:cd18294   1 FAADMKSLIN----NPEFSDVKflVGPERQEIFAHKCILAARCEVFRAMFLTGPQkESTQSPLVLSDIEPEVFRAVLEFI 76

                        90
                ....*....|....*....
gi 29244256  93 YTGEVHISAANVLPLMEAA 111
Cdd:cd18294  77 YTNCVTLSNHTVIEVLAAA 95
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 135-224 1.33e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 58.14  E-value: 1.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 135 NCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGE-EEKVFEALMAWVKHDLQARWR 213
Cdd:cd18479   5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEkEETVREAAMLWLEYNTESRSQ 84

                        90
                ....*....|.
gi 29244256 214 HMQELLQQVRL 224
Cdd:cd18479  85 YLSSVLSQIRI 95
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-121 1.39e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 58.89  E-value: 1.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCShfreSREAKVQMKG-ISSTTLEQVITYVY 93
Cdd:cd18290   9 NFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPAaVQPQSFQQILSFCY 84

                        90       100
                ....*....|....*....|....*...
gi 29244256  94 TGEVHISAANVLPLMEAAAMLQYPRVFE 121
Cdd:cd18290  85 TGRLSMNVGDQFLLMYTAGFLQIQEIME 112
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-127 1.55e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 58.59  E-value: 1.55e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  18 SDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRES-REAKVQMKGISSTTLEQVITYVYTGE 96
Cdd:cd18199   3 SRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTgRPSTASFDVFSSDAFSIILDFVYSGK 82

                        90       100       110
                ....*....|....*....|....*....|.
gi 29244256  97 VHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18199  83 LSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-135 1.75e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 58.96  E-value: 1.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18342   9 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPN 88

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSN 135
Cdd:cd18342  89 LDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 124
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-123 1.76e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 58.82  E-value: 1.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSK-ILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAK-VQMKGISSTTLEQVITYVYT 94
Cdd:cd18207  10 SADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPReLEMHTISSKVFGDILDFAYT 89

                        90       100
                ....*....|....*....|....*....
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFEAC 123
Cdd:cd18207  90 SRIVVRLESFPELMTAAKFLLMRSVIDIC 118
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 35-113 1.79e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 57.53  E-value: 1.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  35 DVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMK--GISSTTLEQVITYVYTGEVHISAA-NVLPLMEAA 111
Cdd:cd18190   1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEenGISIEAMRAVIDFSVTGRLDLFSVeNVHEVLELA 80


                ..
gi 29244256 112 AM 113
Cdd:cd18190  81 SK 82
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-126 2.40e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 58.02  E-value: 2.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSfsSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCshfreSREAKVQMKGISSTTLEQVIT 90
Cdd:cd18206   2 FPQHS--QHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFV-----DQKDVVHLDISNAAGLGQVLE 74

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 29244256  91 YVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSY 126
Cdd:cd18206  75 FMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-126 2.52e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 57.51  E-value: 2.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  35 DVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREA---KVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAA 111
Cdd:cd18307   3 DVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDElsiTIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKGA 82

                        90
                ....*....|....*
gi 29244256 112 AMLQYPRVFEACSSY 126
Cdd:cd18307  83 KYFNIPRLKDHCVDF 97
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-135 2.76e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 58.05  E-value: 2.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  48 HRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEV---HISAANVLPLMEAAAMLQYPRVFEACS 124
Cdd:cd18297  27 HKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVeslDVAQDDALELLRAASFFQLDGLKRHCE 106

                        90
                ....*....|.
gi 29244256 125 SYLQSQLAPSN 135
Cdd:cd18297 107 ILLSQQIDLDN 117
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 133-229 2.94e-10

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 57.49  E-value: 2.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 133 PSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGEEE-KVFEALMAWVKHDLQAR 211
Cdd:cd18466   3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEyQVFTAAMEWILKDVGKR 82

                        90
                ....*....|....*...
gi 29244256 212 WRHMQELLQQVRLQYIHP 229
Cdd:cd18466  83 KKHVVEVLEPVRFPLLPP 100
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-130 3.25e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 57.62  E-value: 3.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  46 PCHRSVLASSSPYFKAMFcSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSS 125
Cdd:cd18231  29 PAHKGVLAAYSQFFHSLF-TQNKQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQE 107


                ....*
gi 29244256 126 YLQSQ 130
Cdd:cd18231 108 LIDSR 112
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-121 3.30e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 58.12  E-value: 3.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQmkgISSTTLEQVITYVYT 94
Cdd:cd18289  11 NFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPAT---VPPACFQQILSFCYT 87

                        90       100
                ....*....|....*....|....*..
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFE 121
Cdd:cd18289  88 GKLTMAASEQLVVMYTAGFLQIQHIVE 114
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-106 5.90e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 57.15  E-value: 5.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGE--- 96
Cdd:cd18279   5 LAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKapn 84

                        90
                ....*....|
gi 29244256  97 VHISAANVLP 106
Cdd:cd18279  85 LDKMADDLLA 94
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 130-224 7.22e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 56.21  E-value: 7.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 130 QLAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDL 208
Cdd:cd18447   1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLtVRAEDQVYDAAVRWLKYDE 80

                        90
                ....*....|....*.
gi 29244256 209 QARWRHMQELLQQVRL 224
Cdd:cd18447  81 PNRQPYMVDILAKVRF 96
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-129 7.56e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 56.96  E-value: 7.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKamfcSHFRESREAKVQMKGISS-TTLEQVITYVYT 94
Cdd:cd18220   8 YSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFR----DHSALSTMSGLSISVIKNpNVFEQLLSFCYT 83

                        90       100       110
                ....*....|....*....|....*....|....*
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQS 129
Cdd:cd18220  84 GRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILES 118
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 19-114 8.27e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 56.50  E-value: 8.27e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  19 DLLRqlngLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVH 98
Cdd:cd18286   7 DLLQ----LFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLD 82

                        90
                ....*....|....*..
gi 29244256  99 I-SAANVLPLMEAAAML 114
Cdd:cd18286  83 LpDDVNLGELLSLADMY 99
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-123 2.15e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 55.26  E-value: 2.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGE 96
Cdd:cd18215   3 ASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYTSR 82

                        90       100
                ....*....|....*....|....*..
gi 29244256  97 VHISAANVLPLMEAAAMLQYPRVFEAC 123
Cdd:cd18215  83 LNLREGNIMAVMATAMYLQMEHVVDTC 109
PHA02713 PHA02713
hypothetical protein; Provisional
 11-458 2.37e-09

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 60.02  E-value: 2.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   11 FKDHSFSSDLLRQLNGLRQSKILTDVSICSG-AWEVPCHRSVLASSSPYFKAMFCS-HFRESREAKVQMKGISSTTLEQV 88
Cdd:PHA02713   3 IDDIKHNRRVVSNISNLLDDDILCDVIITIGdGEEIKAHKTILAAGSKYFRTLFTTpMIIRDLVTRVNLQMFDKDAVKNI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   89 ITYVYTGevHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCLGLV-RLAEILSCdSLKKKAKEVALTYFPEVA 167
Cdd:PHA02713  83 VQYLYNR--HISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYhRLYEMSHI-PIVKYIKRMLMSNIPTLI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  168 ASADLKELCAMELRDYLG--DDRLCGEEEKVFEALMAWVKHDLQARWR--------HMQELLQQVRLqyihpaffhhFIA 237
Cdd:PHA02713 160 TTDAFKKTVFEILFDIIStnDNVYLYREGYKVTILLKWLEYNYITEEQllcilsciDIQNLDKKSRL----------LLY 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  238 NDALLQSSPACQAILemarkqifslygpsaQDCKLLWRMPPRSsyqdfLLLLGGRKDNQQTTRDVLLYSGQTGQWQSLAK 317
Cdd:PHA02713 230 SNKTINMYPSCIQFL---------------LDNKQNRNIIPRQ-----LCLVCHDTKYNVCNPCILVYNINTMEYSVIST 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  318 LPIRLYKASAVTLHRSVYVLGGMTVSEgKSLIScgVYIFSLKLNQWRVGEPMLAARYSHRSTTHRNFIFSIGGTgEGQEL 397
Cdd:PHA02713 290 IPNHIINYASAIVDNEIIIAGGYNFNN-PSLNK--VYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQ-NGTNV 365

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29244256  398 LASMERYDSIRDVWESMAGMPVAVLHPAVAVKDQRLYLFGG--EDIMQNPVRLIQVYHISRNT 458
Cdd:PHA02713 366 ERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGrtEHIDYTSVHHMNSIDMEEDT 428
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-135 2.56e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 55.40  E-value: 2.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18343   8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPN 87

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSN 135
Cdd:cd18343  88 LDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 134-207 2.73e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 54.05  E-value: 2.73e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29244256 134 SNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHD 207
Cdd:cd18474   4 NNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLaVRSEEVVLEAALRWVDAD 78
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-117 2.79e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 55.18  E-value: 2.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFR-ESREAKVQMKGISSTTLEQVITYVYTGEVH 98
Cdd:cd18293   2 AFLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPpAGQKVVLELQGLKAHTLLKLVDFLYTSELE 81

                        90
                ....*....|....*....
gi 29244256  99 ISAANVLPLMEAAAMLQYP 117
Cdd:cd18293  82 VSSEEAQDVLAAARRLQIS 100
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-133 6.39e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 54.06  E-value: 6.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCshFRESREAKVQMKGiSSTTLEQVIT 90
Cdd:cd18214   3 FRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFL--LNDSREVQISILQ-NSEVGRQLLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 29244256  91 YVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAP 133
Cdd:cd18214  80 SCYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-125 7.53e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 53.82  E-value: 7.53e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  35 DVSICSGAWEVPCHRSVLaSSSPYFKAMFCSHFRESREAKVQM----KGISSTTLEQVITYVYTGEVHISAANVLPLMEA 110
Cdd:cd18305  17 DITICALGREWKLHKIYL-CQSGYFASMFSGSWKESKETVINLeipdDNITVEALNVVFGSLYRDEIEIKPSRVVSILAA 95

                        90
                ....*....|....*
gi 29244256 111 AAMLQYPRVFEACSS 125
Cdd:cd18305  96 ATLLQLDGLIQQCSE 110
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-128 1.02e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 52.95  E-value: 1.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  46 PCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQypRVFEAcSS 125
Cdd:cd18319  14 NVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQGDSTDTLEENELLE--DLVEA-AS 90


                ...
gi 29244256 126 YLQ 128
Cdd:cd18319  91 FLQ 93
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-126 1.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 53.22  E-value: 1.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKamfcSHFRESREAKVQMKGISSTTLEQVITYVYTGE 96
Cdd:cd18232   2 SVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQ----SLYGDGTSGSVVLPESFAEVFGLLLDFFYTGE 77

                        90       100       110
                ....*....|....*....|....*....|
gi 29244256  97 VHISAANVLPLMEAAAMLQYPRVFEACSSY 126
Cdd:cd18232  78 LALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-119 1.17e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 53.36  E-value: 1.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFK-------------AMFCSHFRESREAKVQMKGISSTTLE 86
Cdd:cd18195   5 LLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRellssplplgaaaVAAAPGATQSPERVLELPGVKAGVFS 84

                        90       100       110
                ....*....|....*....|....*....|....
gi 29244256  87 QVITYVYTGEVHI-SAANVLPLMEAAAMLQYPRV 119
Cdd:cd18195  85 DVLNFIYSSRVALpGSAAAKELGAAGKRLGIPFL 118
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 133-186 1.30e-08

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 51.12  E-value: 1.30e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 29244256 133 PSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGD 186
Cdd:cd14733   2 PENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 135-224 1.33e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 52.81  E-value: 1.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 135 NCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALMAWVKHDLQARWR 213
Cdd:cd18462   5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLnVWKEEVLIEAVVKWVAHDVEKRIE 84

                        90
                ....*....|.
gi 29244256 214 HMQELLQQVRL 224
Cdd:cd18462  85 CAYDLLSSIKL 95
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 135-230 1.44e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 52.97  E-value: 1.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 135 NCLGLVRLAEILSC--DSLKKKAKEVALTYFPEVAASAD-LKELCAMELRDYLGDDRLCGEEE-KVFEALMAWVKHDlQA 210
Cdd:cd18454   5 NCAEIMRLLDDFSVniEGVREKLDSFLLENFVPLMSRPDfLSYLSFEKLMSYLDNDHLSRFPEiELYEAVQAWLRHD-RR 83

                        90       100
                ....*....|....*....|
gi 29244256 211 RWRHMQELLQQVRLQYIHPA 230
Cdd:cd18454  84 RWRHTDTIIQNIRFCLMTPT 103
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-124 2.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 52.76  E-value: 2.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  14 HSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVqmkgISSTTLEQVITYVY 93
Cdd:cd18208   6 HNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMY 81

                        90       100       110
                ....*....|....*....|....*....|.
gi 29244256  94 TGEVHISAANVLPLMEAAAMLQYPRVFEACS 124
Cdd:cd18208  82 SGVLRVSQSEALQILTAASILQIKTVIDECT 112
Kelch smart00612
Kelch domain;
480-521 2.66e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 50.25  E-value: 2.66e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 29244256    480 QIVIVGGY-----TRRILAYDPQSNKFVKCADMKDRRMHHGATVMGN 521
Cdd:smart00612   1 KIYVVGGFdggqrLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-127 3.31e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 51.77  E-value: 3.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFkamfcshfresrEAKVQMKGISSTTL---------E 86
Cdd:cd18210   4 ITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYF------------HDQVLLKNMSSISLpgvmdpgafE 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 29244256  87 QVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18210  72 SVLASAYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 510-560 3.53e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.53  E-value: 3.53e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 29244256   510 RRMHHGATVMGNKLYVTGGRRLTTDCNiedsaSFDCYDPETDTWTSQGQLP 560
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLN-----SVEVYDPETNTWSKLPSMP 46
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-96 4.14e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 51.77  E-value: 4.14e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29244256  24 LNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGE 96
Cdd:cd18345   9 LGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK 81
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-133 6.87e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 51.42  E-value: 6.87e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  21 LRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCshFRESREAKVQMKGiSSTTLEQVITYVYTGEVHIS 100
Cdd:cd18203  13 LRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSLMH-SSRVVADLLLSCYTGALEFS 89

                        90       100       110
                ....*....|....*....|....*....|...
gi 29244256 101 AANVLPLMEAAAMLQYPRVFEACSSYLQSQLAP 133
Cdd:cd18203  90 VRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-131 8.19e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 50.47  E-value: 8.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  41 GAWEVPCHRSVLASSSPYFKAMFCSHFRESReAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVF 120
Cdd:cd18282  19 GTQRIPAHKYVLATGSSVFYAMFYGGLAENK-NEIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLA 97

                        90
                ....*....|.
gi 29244256 121 EACSSYLQSQL 131
Cdd:cd18282  98 RACVQFLETSL 108
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-135 1.08e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 50.90  E-value: 1.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  45 VPCHRSVLASSSPYFKAMFCSHFReSREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACS 124
Cdd:cd18281  38 IPAHKFVLSIGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACV 116

                        90
                ....*....|.
gi 29244256 125 SYLQSQLAPSN 135
Cdd:cd18281 117 EFLKKNLSSDN 127
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-124 1.09e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 50.24  E-value: 1.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVqmkgISSTTLEQVITYVYTG 95
Cdd:cd18229   1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPV----VPAQTVRQLVEFMYSG 76

                        90       100
                ....*....|....*....|....*....
gi 29244256  96 EVHISAANVLPLMEAAAMLQYPRVFEACS 124
Cdd:cd18229  77 SLVVAQSEALQILTAASILQIKTVIDECT 105
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
505-572 1.26e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 53.24  E-value: 1.26e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29244256 505 ADMKDRRMHHGATVMGNKLYVTGGRRLTTDcniedSASFDCYDPETDTWTSQGQLPHKLFDHACLTLQ 572
Cdd:COG3055   7 PDLPTPRSEAAAALLDGKVYVAGGLSGGSA-----SNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQ 69
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-127 1.60e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 49.94  E-value: 1.60e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCShfrESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18218   5 LLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTN---PNPGQWCLGEGISPSTFKQLLDFVYGESVEV 81

                        90       100
                ....*....|....*....|....*...
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18218  82 QPGELRPLLEAARALEVESLEEACWRAL 109
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-131 1.78e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 50.24  E-value: 1.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256   9 VVFKDHSFSSDLLRQLNGLRQSKILTDVSIC----SGAWEVPCHRSVLASSSPYFKAMFCS-HFRESREAKVQMKGISST 83
Cdd:cd18211   1 VLLESKSAPSNLLNEMHKLRLLGHLCDVTVQvehqGSKEEFSAHKAVLAASSKYFKEVFLNeKISDGKNTNVMLNEIYTA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 29244256  84 TLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSyLQSQL 131
Cdd:cd18211  81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQ-LKKQM 127
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-126 1.82e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 49.79  E-value: 1.82e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHfRESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18212  10 VLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADE-GEVGQSIYMLEGMVAETFGALLEFIYTGCLQV 88

                        90       100
                ....*....|....*....|....*..
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACSSY 126
Cdd:cd18212  89 GEKSLEQILATAQFLKVNDLVKAYSDY 115
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-133 2.46e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 49.66  E-value: 2.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKG--ISSTTLEQVITYVYTGEV 97
Cdd:cd18196   8 IFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALIDMMYTSTL 87

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 29244256  98 HISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAP 133
Cdd:cd18196  88 MLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLP 123
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-135 3.11e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 49.63  E-value: 3.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  41 GAWEVPCHRSVLASSSPYFKAMFCSHFRESREaKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVF 120
Cdd:cd18348  33 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLA 111

                        90
                ....*....|....*
gi 29244256 121 EACSSYLQSQLAPSN 135
Cdd:cd18348 112 RACVNFLETSLSAKN 126
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-127 3.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 49.10  E-value: 3.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCshFRESREAKVQMKGiSSTTLEQVIT 90
Cdd:cd18197   3 FKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFL--LNQSKQVRITILQ-SAEVGRKLLL 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 29244256  91 YVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18197  80 SCYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-127 3.86e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 49.08  E-value: 3.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGE 96
Cdd:cd18331   8 ASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYTSR 87

                        90       100       110
                ....*....|....*....|....*....|.
gi 29244256  97 VHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18331  88 LNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-125 3.88e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 49.08  E-value: 3.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSH-FRESREAKVQMKGISSTTLEQVITYVYTGEVH 98
Cdd:cd18202   6 VLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKgAVSSHEAVVDLSGFCKSSFLPLLEFAYTSELT 85

                        90       100
                ....*....|....*....|....*..
gi 29244256  99 ISAANVLPLMEAAAMLQYPRVFEACSS 125
Cdd:cd18202  86 FDFCSMAEVAMLARHLFMNEVLEICES 112
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-106 4.44e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 49.18  E-value: 4.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEV-- 97
Cdd:cd18344  10 LTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAph 89

                        90
                ....*....|..
gi 29244256  98 ---HISAANVLP 106
Cdd:cd18344  90 lhsHSMACDVLA 101
Kelch smart00612
Kelch domain;
522-572 5.14e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.40  E-value: 5.14e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 29244256    522 KLYVTGGRRlttdcNIEDSASFDCYDPETDTWTSQGQLPHKLFDHACLTLQ 572
Cdd:smart00612   1 KIYVVGGFD-----GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-128 7.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 48.42  E-value: 7.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCshfrESREAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18334   3 NHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVL----HDNLINLDTDMVNPTVFRQILDFIYT 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 29244256  95 GEV----HISAANVLPLMEAAAMLQYPRVFEACSSYLQ 128
Cdd:cd18334  79 GKLltsdQPGEQNFNALLTAASYLQLHDLAALCRKKLK 116
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 33-97 7.81e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 48.13  E-value: 7.81e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29244256  33 LTDVSI-CSGAWEVPCHRSVLASSSPYFKAMFCSHFRE-SREAKVQMKgISSTTLEQVITYVYTGEV 97
Cdd:cd18302   5 LYDVTIvSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTMP-IPSDILEIILDYLYTDEA 70
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-131 1.31e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 47.28  E-value: 1.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  45 VPCHRSVLASSSPYFKAMFCSHFRESrEAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACS 124
Cdd:cd18349  24 VPAHKYVLAVGSSVFYAMFYGDLAEV-KSEIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKACV 102


                ....*..
gi 29244256 125 SYLQSQL 131
Cdd:cd18349 103 NFLETSL 109
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 33-111 1.34e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 47.47  E-value: 1.34e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29244256  33 LTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAA 111
Cdd:cd18352  13 LSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAA 91
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-115 1.46e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 47.12  E-value: 1.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18192   3 SHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMYL 82

                        90       100
                ....*....|....*....|.
gi 29244256  95 GEVHISAANVLPLMEAAAMLQ 115
Cdd:cd18192  83 GKIMTAPSDFEQLKVAMNYLQ 103
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-127 1.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 47.14  E-value: 1.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCShfreSREAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18216   2 SHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLH----DNLIHLDQDMVSPTVFQQILDFIYT 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 29244256  95 GEVHISA---ANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18216  78 GKLLDSLfeePNLSEVLAAANYLQLPDLAALCRSKL 113
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 45-127 1.84e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 46.44  E-value: 1.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  45 VPCHRSVLASSSPYFKAMFCSHfresreAKVQM-KGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEAC 123
Cdd:cd18299  25 IFAHRIVLAAASSVFADLFLMM------TVVTLdSDITPEAFRRVLEFLYTGVLDENEDDLKELKDAAELLELFDLVMMC 98


                ....
gi 29244256 124 SSYL 127
Cdd:cd18299  99 TNVL 102
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 131-217 2.69e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 45.72  E-value: 2.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGEEEKV-FEALMAWVKHDLQ 209
Cdd:cd18451   1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVlFEAVLKWVQRNAE 80


                ....*...
gi 29244256 210 ARWRHMQE 217
Cdd:cd18451  81 ERERYFEE 88
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-131 2.85e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 46.38  E-value: 2.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  30 SKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGE-VHISAANVLPLM 108
Cdd:cd18360   7 SPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDScCPASILQAMALL 86

                        90       100
                ....*....|....*....|...
gi 29244256 109 EAAAMLQYPRVFEACSSYLQSQL 131
Cdd:cd18360  87 ICAEMYQVSRLQHICELYIITQL 109
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-129 3.38e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 46.36  E-value: 3.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVqmkgISSTTLEQVITYVYT 94
Cdd:cd18225   5 NYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASV----VSPEEFALLLEMVYT 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 29244256  95 GEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQS 129
Cdd:cd18225  81 GKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTS 115
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-127 4.46e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 46.21  E-value: 4.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFC----SHFRESREAKVQMKGissttLEQVITYV 92
Cdd:cd18277  11 STNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVgqadAELNITLPEEVTVKG-----FEPLIQFA 85

                        90       100       110
                ....*....|....*....|....*....|....*
gi 29244256  93 YTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18277  86 YTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-128 4.70e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 45.65  E-value: 4.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREA-KVQMKGISSttLEQVITYVYTG 95
Cdd:cd18233   2 SCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVfHLDIKNVGG--IGQILDFMYTS 79

                        90       100       110
                ....*....|....*....|....*....|...
gi 29244256  96 EVHISAANVLPLMEAAAMLQYPRVFEACSSYLQ 128
Cdd:cd18233  80 HLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-107 8.09e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 44.97  E-value: 8.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCS-HFRESREAKVQMK--GISSTTLEQVITYVY 93
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNdWWSESKQSEIELVedPECAAVFEKFLRYLY 80

                        90
                ....*....|....
gi 29244256  94 TGEVHISAANVLPL 107
Cdd:cd18292  81 TGQISVNLETALPL 94
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 8.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 45.58  E-value: 8.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSfsSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKamFCSHFRESREAKVQMKG--ISSTTLEQV 88
Cdd:cd18194   3 FPEHS--RQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH--LFYRDRLDKRDLVRLNSdiVTAPAFGLL 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 29244256  89 ITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQL 131
Cdd:cd18194  79 LDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKA 121
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-124 9.47e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 45.03  E-value: 9.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAkVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18204   5 FLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSV-IEIDFLRSDIFEEVLNYMYTAKISV 83

                        90       100
                ....*....|....*....|....*
gi 29244256 100 SAANVLPLMEAAAMLQYPRVFEACS 124
Cdd:cd18204  84 KKEDVNLMMSSGQILGIRFLDKLCS 108
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-127 1.08e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 44.00  E-value: 1.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  33 LTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQmKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAA 112
Cdd:cd18955   1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDLVITLP-EEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAE 79

                        90
                ....*....|....*
gi 29244256 113 MLQYPRVFEACSSYL 127
Cdd:cd18955  80 FLGVHNIEKACFDFL 94
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 27-119 1.09e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 44.51  E-value: 1.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  27 LRQSKILTDVSICSGAWEVPCHRSVLASSSpyfkamfcSHFRE----SREAKVQMKG-ISSTTLEQVITYVYTGEVHISA 101
Cdd:cd18262  12 LREQRLLLDETVSVGGRSYGVHSVILAAVS--------SLFRErllgSNGPLPPLSLeVTPVGWEAVLTFAYTGVLGRNP 83

                        90
                ....*....|....*...
gi 29244256 102 ANVLPLMEAAAMLQYPRV 119
Cdd:cd18262  84 ATVGDILVAAEALGAPRV 101
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-110 1.11e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 45.07  E-value: 1.11e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29244256  34 TDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGI--SSTTLEQVITYVYTGEVHISAANVLPLMEA 110
Cdd:cd18309  21 CDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMvpSRQAFDSLLRYIYYGDVTMPPEDSLYLFSA 99
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-109 1.30e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 44.48  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAkVQMKGISSTTLEQVITYVYTGE 96
Cdd:cd18209   2 AISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQSV-FQLDFCEPDAFENVLNYIYSSS 80

                        90
                ....*....|...
gi 29244256  97 VHISAANVLPLME 109
Cdd:cd18209  81 LFVEKSSLAAVQE 93
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-123 1.42e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 44.25  E-value: 1.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  18 SDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFcshFRESREAKVQMkgISSTTLEQVITYVYTGEV 97
Cdd:cd18205   3 TGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF---HRNSQHYTLDF--LSPKTFQQILEYAYTATL 77

                        90       100
                ....*....|....*....|....*.
gi 29244256  98 HISAANVLPLMEAAAMLQYPRVFEAC 123
Cdd:cd18205  78 QAKVEDLDDLLYAAEILEIEYLEEQC 103
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-130 1.69e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 44.64  E-value: 1.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSfsSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVIT 90
Cdd:cd18325   3 FPDHS--RQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 29244256  91 YVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQ 130
Cdd:cd18325  81 FMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKDK 120
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-135 2.25e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 44.28  E-value: 2.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  41 GAWEVPCHRSVLASSSPYFKAMFCSHFrESREAKVQMKGISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVF 120
Cdd:cd18346  40 GAQRIPAHRFVLAAGSAVFDAMFNGGM-ATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 118

                        90
                ....*....|....*
gi 29244256 121 EACSSYLQSQLAPSN 135
Cdd:cd18346 119 AHCVEFLTKHLRADN 133
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-115 2.43e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 43.84  E-value: 2.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFcSHFreSREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18221   5 MLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF-QDF--TQEPLVEIEGVSNMAFRHLIEFTYTAKLMV 81

                        90       100
                ....*....|....*....|....*.
gi 29244256 100 S----------AANVLPLMEAAAMLQ 115
Cdd:cd18221  82 QgeeeandvwkAAEYLQMQEAIKALE 107
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-130 3.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 43.66  E-value: 3.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSfsSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKaMFCSHFRESREAK-VQMKGISSTTLEQVI 89
Cdd:cd18323   3 FPDHS--RHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYKEQLDKRDLVcINNEIVTAPAFSLLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 29244256  90 TYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQ 130
Cdd:cd18323  80 EFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQAR 120
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 46-104 5.22e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 43.01  E-value: 5.22e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 29244256  46 PCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVHISAANV 104
Cdd:cd18295  32 PAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLEIHVDDV 90
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-93 1.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 41.72  E-value: 1.04e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 29244256  45 VPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVY 93
Cdd:cd18191  14 LPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHYLH 62
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 131-219 1.50e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 41.00  E-value: 1.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 131 LAPSNCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRLCGE-EEKVFEALMAWVKHDLQ 209
Cdd:cd18483   1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEkEEHVYESIIHWFEHEQS 80

                        90
                ....*....|
gi 29244256 210 ARWRHMQELL 219
Cdd:cd18483  81 KREMHLPEIF 90
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-127 1.51e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 41.86  E-value: 1.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  10 VFKDHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRE----SREAKVQMKGISSttl 85
Cdd:cd18278   8 VYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENdlvvSLPEEVTARGFGP--- 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 29244256  86 eqVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYL 127
Cdd:cd18278  85 --LLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-128 1.80e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 41.43  E-value: 1.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCshfrESREAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18333   3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVV----HDNLINLDHEMVSPGIFRLILDYIYT 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 29244256  95 GEV----HISAANVLPLMEAAAMLQYPRVFEACSSYLQ 128
Cdd:cd18333  79 GRLsegdPGSEQNLGAVLAAASYLQIPDLVALCKKKLK 116
Kelch smart00612
Kelch domain;
385-428 1.83e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 1.83e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 29244256    385 IFSIGGTGeGQELLASMERYDSIRDVWESMAGMPVAVLHPAVAV 428
Cdd:smart00612   2 IYVVGGFD-GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAV 44
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 470-508 1.91e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 1.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 29244256   470 VCAPAVVLGEQIVIVGGY-----TRRILAYDPQSNKFVKCADMK 508
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFdgnqsLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 135-223 2.72e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 40.27  E-value: 2.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256 135 NCLGLVRLAEILSCDSLKKKAKEVALTYFPEVAASADlKELCAME---LRDYLGDDRLCG-EEEKVFEALMAWVKHDlqA 210
Cdd:cd18471   5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKSHP-EEVLALPyrlLREVLKSDRLTSlSEEQIWQLAVRWLEHN--C 81

                        90
                ....*....|...
gi 29244256 211 RWRHMQELLQQVR 223
Cdd:cd18471  82 RYQYMDELLQYVR 94
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
280-341 3.13e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 42.84  E-value: 3.13e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29244256 280 SSYQDFLLLLGGRKdnqQTTRDVLLYSGQTGQWQSLAKLPIRLYKASAVTLHRSVYVLGGMT 341
Cdd:COG3055 203 AVLGGKILVFGGES---GFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGET 261
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-135 3.30e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 40.83  E-value: 3.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  27 LRQSKILTDVSICSG----AWEVPCHRSVLASSSPYFKAMFCSHFrESREAKVQMKGISSTTLEQVITYVYTGEVHISAA 102
Cdd:cd18347  16 LFNNEVLSDVHFLVGkglgSQRIPAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPE 94

                        90       100       110
                ....*....|....*....|....*....|...
gi 29244256 103 NVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSN 135
Cdd:cd18347  95 TVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-136 3.70e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 40.38  E-value: 3.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFREsreakVQMKGISSTTLEQVITYVYTG 95
Cdd:cd18303   1 FISRLLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSEKWSNENLASTNE-----LDLSDISYEVVLALLRWLYTD 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 29244256  96 EVHIS--AANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNC 136
Cdd:cd18303  76 ELDLTldDEFLLELMKAAKRFQLTDLVERCERALMSSVNVDNC 118
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-130 3.89e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 41.18  E-value: 3.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  11 FKDHSfsSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVIT 90
Cdd:cd18324   3 FPDHS--RHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 29244256  91 YVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQ 130
Cdd:cd18324  81 FMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 120
Kelch_3 pfam13415
Galactose oxidase, central domain;
478-518 4.32e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.43  E-value: 4.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 29244256   478 GEQIVIVGGYTR-------RILAYDPQSNKFVKCADMKDRRMHHGATV 518
Cdd:pfam13415   1 GDKLYIFGGLGFdgqtrlnDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 510-554 4.81e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 38.09  E-value: 4.81e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 29244256   510 RRMHHGATVMGNKLYVTGGRRLTTDCNIEDSAsfdCYDPETDTWT 554
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSSDVL---VYDPETNVWT 42
Kelch_6 pfam13964
Kelch motif;
474-511 5.38e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 5.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 29244256   474 AVVLGEQIVIVGGYT------RRILAYDPQSNKFVKCADMKDRR 511
Cdd:pfam13964   7 VVSVGGYIYVFGGYTnaspalNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 372-418 5.49e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.98  E-value: 5.49e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 29244256   372 ARYSHRSTTHRNFIFSIGGTGeGQELLASMERYDSIRDVWESMAGMP 418
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFD-GNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 33-97 6.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 40.37  E-value: 6.11e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29244256  33 LTDVSI-CSGAWEVPCHRSVLASSSPYFKAMFCSHFRES--REAKVQMK------GISSTTLEQVITYVYTGEV 97
Cdd:cd18310  18 YSDAEIiVEGGRPVPVHRCILAARSPFFRDIFASAKAEGanTKPKLELRelipggIVGYDAFMLVLSYLYSGRL 91
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-142 6.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 40.00  E-value: 6.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  23 QLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEvhisaa 102
Cdd:cd18280   4 HFGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDE------ 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 29244256 103 nvLPLMEAAAMLQYPRVFEACSSYLqsqLAPSNCLGLVRL 142
Cdd:cd18280  78 --LPDDVEPAGSDSSSLDTTMAQHL---LAAADRYALERL 112
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-97 6.78e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 39.77  E-value: 6.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  17 SSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGE 96
Cdd:cd18223   2 SDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYSSK 81


                .
gi 29244256  97 V 97
Cdd:cd18223  82 V 82
BTB_POZ_EloC cd18321
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 53-115 7.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins; Elongin-C is also called elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, or transcription elongation factor B polypeptide 1 (TCEB1). It is a component of SIII (also known as elongin), which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. It forms a regulatory complex with subunit B or elongin-B (BC) that enhances the activity of the transcriptionally active subunit A. The BC complex also functions as an adaptor protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC (VHL) and the suppressors of cytokine signaling (SOCS) box ubiquitin ligase family. Elongin-C belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349630  Cd Length: 95  Bit Score: 39.11  E-value: 7.29e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29244256  53 ASSSPYFKAMFCSHFR--ESREAKVQMKGISSTTLEQVITYV-----YTG------EVHISAANVLPLMEAAAMLQ 115
Cdd:cd18321  19 AMVSGTIKAMLSGPGQfaENETNEVRFPEISSHILEKVCEYFyykvrYTNssteipEFPIPPEIALELLMAANFLD 94
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-122 9.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 39.20  E-value: 9.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCShfRESREAKVQMKGISSTTLEQVITYVYTGEVHI 99
Cdd:cd18193   8 LLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVH--QTSECVRLKPTDIQPDIFSYLLHLMYTGKMAP 85

                        90       100
                ....*....|....*....|....
gi 29244256 100 SAANVLPLMEAAAMLQ-YPRVFEA 122
Cdd:cd18193  86 QLIDPVRLEQGIKFLHaYPLIQEA 109
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-96 9.38e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 38.47  E-value: 9.38e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29244256  34 TDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMK--GISSTTLEQVITYVYTGE 96
Cdd:cd18283   3 TDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPtaGIDVPMFSALLRYLYTGE 67
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 33-131 1.07e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 39.18  E-value: 1.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  33 LTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLEQVITYVYTGEVH-ISAANVLPLMEAA 111
Cdd:cd18358  20 FSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSpTADLDPLELIALA 99

                        90       100
                ....*....|....*....|
gi 29244256 112 AMLQYPRVFEACSSYLQSQL 131
Cdd:cd18358 100 NRFCLPHLVALTEQHAVQEL 119
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-95 1.09e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 39.49  E-value: 1.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  15 SFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESreAKVQMKGISSTTLEQVITYVYT 94
Cdd:cd18213   3 SHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSEC--IKIQPTDIQPDIFSYLLHIMYT 80


                .
gi 29244256  95 G 95
Cdd:cd18213  81 G 81
Kelch smart00612
Kelch domain;
334-383 1.14e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 1.14e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 29244256    334 VYVLGGMTVSEgkslISCGVYIFSLKLNQWRVGEPMLAARYSHRSTTHRN 383
Cdd:smart00612   2 IYVVGGFDGGQ----RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_6 pfam13964
Kelch motif;
511-561 1.18e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.93  E-value: 1.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 29244256   511 RMHHGATVMGNKLYVTGGRrlttDCNIEDSASFDCYDPETDTWTSQGQLPH 561
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGY----TNASPALNKLEVYNPLTKSWEELPPLPT 48
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-128 1.30e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 38.68  E-value: 1.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFcshFRESREAKVQMKGISSTTLEQVITYVYTG 95
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKL---LLNDTNCLVLPSVIEAAAFENLLQLIYSG 77

                        90       100       110
                ....*....|....*....|....*....|...
gi 29244256  96 EVHISAANVLPLMEAAAMLQYPRVFEACSSYLQ 128
Cdd:cd18200  78 RLTLCMDALPSHLLVASGLQMWQVVDRCSELLK 110
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 16-95 1.35e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 38.42  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  16 FSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREA-KVQMKGISSTT---LEQVITY 91
Cdd:cd18301   1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAvGCDVVHIEKVPpeiFEQLLQF 80


                ....
gi 29244256  92 VYTG 95
Cdd:cd18301  81 IYTD 84
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-97 1.52e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 38.27  E-value: 1.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  13 DHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFResreaKVQMKGISSTTLEQVITYV 92
Cdd:cd18219   1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAGQ-----VVELNFIRADIFAEILNYI 75


                ....*
gi 29244256  93 YTGEV 97
Cdd:cd18219  76 YSSKI 80
Kelch_6 pfam13964
Kelch motif;
281-321 1.67e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 1.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 29244256   281 SYQDFLLLLGGRKDNQQTTRDVLLYSGQTGQWQSLAKLPIR 321
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTP 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 325-369 1.88e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 1.88e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 29244256   325 ASAVTLHRSVYVLGGMTVSEgkslISCGVYIFSLKLNQWRVGEPM 369
Cdd:pfam01344   5 AGVVVVGGKIYVIGGFDGNQ----SLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 44-115 1.97e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 38.34  E-value: 1.97e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29244256  44 EVPCHRSVLASSSPYFKAMfcSHFRESREAKVQMKG-ISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQ 115
Cdd:cd18311  26 QLKVHRLVLSACTDYFNVL--EQTCEIVDDTLIMPNeLQADAVVPVINFMYTGQLEFEEKSYGKLLRTAKELN 96
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-128 2.47e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 38.26  E-value: 2.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAkVQMKG--ISSTTLEQVITYVYTGEV 97
Cdd:cd18956  10 LLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRDT-VRLNGdiVTAPAFGRLLDFMYEGRL 88

                        90       100       110
                ....*....|....*....|....*....|.
gi 29244256  98 HISAANVLPLMEAAAMLQYPRVFEACSSYLQ 128
Cdd:cd18956  89 DLRSLPVEDVLAAASYLHMYDIVKVCKGRLR 119
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-115 5.44e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 36.25  E-value: 5.44e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29244256  49 RSVLASSSPYFKAMFCSHFRESREAKVQMKGISSTTLeQVITYVYTGEVHISAAN-VLPLMEAAAMLQ 115
Cdd:cd18320  17 KALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGF-RIMLRVLAGERPILNGEeILQAIECAAFLQ 83
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 28-115 5.62e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 36.93  E-value: 5.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  28 RQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMfCSHFRESREAKVQMKGI--SSTTLEQVITYVYTGEVHISAANVL 105
Cdd:cd18312   4 RDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRL-ASSSSESDPSEIELNDFpgGAEAFELVAKFCYGMPINLTATNVV 82

                        90
                ....*....|
gi 29244256 106 PLMEAAAMLQ 115
Cdd:cd18312  83 GLRCAAEYLE 92
Kelch_4 pfam13418
Galactose oxidase, central domain;
284-319 5.74e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 5.74e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 29244256   284 DFLLLLGGRKDNQQTTRDVLLYSGQTGQWQSLAKLP 319
Cdd:pfam13418  13 DTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSLP 48
Kelch_3 pfam13415
Galactose oxidase, central domain;
520-560 8.65e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.57  E-value: 8.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 29244256   520 GNKLYVTGGRrltTDCNIEDSASFDCYDPETDTWTSQGQLP 560
Cdd:pfam13415   1 GDKLYIFGGL---GFDGQTRLNDLYVYDLDTNTWTQIGDLP 38
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-114 9.61e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 36.32  E-value: 9.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244256  20 LLRQLNG--LRQSKILTDVSICSGAwEVPCHRSVLASSSPYFKAMFCshfRESREAKVQMKGISSTTLEQVITYVYTGEV 97
Cdd:cd18226   8 LLKYLNDdrQKQSSFCDLVITVEGK-EFSAHKVVVAVGSSYFHACLS---KNPNTDAVTLDHVSYSVFQHLLEFLYTSEF 83

                        90
                ....*....|....*..
gi 29244256  98 HISAANVLPLMEAAAML 114
Cdd:cd18226  84 FVYENEIPLVLEAAKFL 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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