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Conserved domains on  [gi|29244160|ref|NP_808376|]
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reticulon-4 receptor-like 1 precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-255 5.11e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 5.11e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160  57 ERIFLQNNRITFLQQGHFS-PAMVTLWIYSNNITFIaPNTFEGFVHLEELDLGDNrQLRTLaPETFQGLVKLHALYLYKC 135
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN-QLTDL-PEELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 136 GLSALPAGIfGGLHSLQYLYLQDNHIEYLQDDIfVDLVNLSHLFLHGNKLWSLGQgiFRGLVNLDRLLLHENQLQWVhhK 215
Cdd:COG4886 193 QITDLPEPL-GNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDL--P 266

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 29244160 216 AFHDLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGN 255
Cdd:COG4886 267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-255 5.11e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 5.11e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160  57 ERIFLQNNRITFLQQGHFS-PAMVTLWIYSNNITFIaPNTFEGFVHLEELDLGDNrQLRTLaPETFQGLVKLHALYLYKC 135
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN-QLTDL-PEELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 136 GLSALPAGIfGGLHSLQYLYLQDNHIEYLQDDIfVDLVNLSHLFLHGNKLWSLGQgiFRGLVNLDRLLLHENQLQWVhhK 215
Cdd:COG4886 193 QITDLPEPL-GNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDL--P 266

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 29244160 216 AFHDLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGN 255
Cdd:COG4886 267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
174-233 3.26e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 3.26e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160   174 NLSHLFLHGNKLWSLGQGIFRGLVNLDRLLLHENQLQWVHHKAFHDLHRLTTLFLFNNSL 233
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 126-255 1.62e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 1.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 126 KLHALYLYKCGLSALPAgiFGGLHSLQYLYLQDNHIEYLQDdiFVDLVNLSHLFLHGNKLWSLGQgiFRGLVNLDRLLLH 205
Cdd:cd21340   3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 206 ENQLQWVhhKAFHDLHRLTTL------------FLF------------------NNSLTELQgdCLAPLVALEFLRLNGN 255
Cdd:cd21340  77 GNRISVV--EGLENLTNLEELhienqrlppgekLTFdprslaalsnslrvlnisGNNIDSLE--PLAPLRNLEQLDASNN 152
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
37-176 1.23e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160   37 TVSCQAHNFAAIPEGIPEDSERIFLQNNRITFLQQgHFSPAMVTLWIYSNNITFIAPNTFEGfvhLEELDLGDNrQLRTL 116
Cdd:PRK15370 224 TLYANSNQLTSIPATLPDTIQEMELSINRITELPE-RLPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDN-SIRTL 298

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160  117 APETFQGLVKlhaLYLYKCGLSALPAGIFGGLHSLQylyLQDNHIEYLQDDIFVDLVNLS 176
Cdd:PRK15370 299 PAHLPSGITH---LNVQSNSLTALPETLPPGLKTLE---AGENALTSLPASLPPELQVLD 352
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-255 5.11e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 5.11e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160  57 ERIFLQNNRITFLQQGHFS-PAMVTLWIYSNNITFIaPNTFEGFVHLEELDLGDNrQLRTLaPETFQGLVKLHALYLYKC 135
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN-QLTDL-PEELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 136 GLSALPAGIfGGLHSLQYLYLQDNHIEYLQDDIfVDLVNLSHLFLHGNKLWSLGQgiFRGLVNLDRLLLHENQLQWVhhK 215
Cdd:COG4886 193 QITDLPEPL-GNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDL--P 266

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 29244160 216 AFHDLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGN 255
Cdd:COG4886 267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-255 2.93e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160  85 SNNITFIAPNTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLsalpagiFGGLHSLQYLYLQDNHIEYL 164
Cdd:COG4886  56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDL 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 165 QDDIFvDLVNLSHLFLHGNKLWSLGQGIFrGLVNLDRLLLHENQLQWVhHKAFHDLHRLTTLFLFNNSLTELqGDCLAPL 244
Cdd:COG4886 129 PEELA-NLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNL 204

                       170
                ....*....|.
gi 29244160 245 VALEFLRLNGN 255
Cdd:COG4886 205 TNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-273 1.33e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 1.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160  57 ERIFLQNNRITFLQQgHFS--PAMVTLWIYSNNITFIaPNTFEGFVHLEELDLGDNrQLRTLaPEtFQGLVKLHALYLYK 134
Cdd:COG4886 185 KELDLSNNQITDLPE-PLGnlTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN-QLTDL-PE-LGNLTNLEELDLSN 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 135 CGLSALPAgiFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLshLFLHGNKLWSLGQGIFRGLVNLDRLLLHENQLQWVHH 214
Cdd:COG4886 260 NQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGL--NSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 29244160 215 KAFHDLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGNAWDCGCRARSLWEWLRRF 273
Cdd:COG4886 336 TLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
LRR_8 pfam13855
Leucine rich repeat;
174-233 3.26e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 3.26e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160   174 NLSHLFLHGNKLWSLGQGIFRGLVNLDRLLLHENQLQWVHHKAFHDLHRLTTLFLFNNSL 233
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 126-255 1.62e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 1.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 126 KLHALYLYKCGLSALPAgiFGGLHSLQYLYLQDNHIEYLQDdiFVDLVNLSHLFLHGNKLWSLGQgiFRGLVNLDRLLLH 205
Cdd:cd21340   3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 206 ENQLQWVhhKAFHDLHRLTTL------------FLF------------------NNSLTELQgdCLAPLVALEFLRLNGN 255
Cdd:cd21340  77 GNRISVV--EGLENLTNLEELhienqrlppgekLTFdprslaalsnslrvlnisGNNIDSLE--PLAPLRNLEQLDASNN 152
LRR_8 pfam13855
Leucine rich repeat;
126-185 1.16e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.16e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160   126 KLHALYLYKCGLSALPAGIFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKL 185
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
150-209 2.25e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 2.25e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160   150 SLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGQGIFRGLVNLDRLLLHENQL 209
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 59-207 3.23e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 3.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160  59 IFLQNNRITFLQQGHFSPAMVTLWIYSNNITFIAPntFEGFVHLEELDLGDNRqLRTLapETFQGLVKLHALYLYK---- 134
Cdd:cd21340  29 LYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR-ISVV--EGLENLTNLEELHIENqrlp 103

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29244160 135 --CGLSALPAGIFGGLHSLQYLYLQDNHIEYLQDdiFVDLVNLSHLFLHGNKLWSLGQ--GIFRGLVNLDRLLLHEN 207
Cdd:cd21340 104 pgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
198-255 3.23e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 3.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 29244160   198 NLDRLLLHENQLQWVHHKAFHDLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGN 255
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
101-161 6.48e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 6.48e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29244160   101 HLEELDLGDNRqLRTLAPETFQGLVKLHALYLYKCGLSALPAGIFGGLHSLQYLYLQDNHI 161
Cdd:pfam13855   2 NLRSLDLSNNR-LTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
85-132 2.36e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 2.36e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 29244160    85 SNNITFIAPNTFEGFVHLEELDLGDNRqLRTLAPETFQGLVKLHALYL 132
Cdd:pfam13855  10 NNRLTSLDDGAFKGLSNLKVLDLSNNL-LTTLSPGAFSGLPSLRYLDL 56
LRR_8 pfam13855
Leucine rich repeat;
57-111 3.01e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 3.01e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 29244160    57 ERIFLQNNRITFLQQGHFS--PAMVTLWIYSNNITFIAPNTFEGFVHLEELDLGDNR 111
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
37-176 1.23e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160   37 TVSCQAHNFAAIPEGIPEDSERIFLQNNRITFLQQgHFSPAMVTLWIYSNNITFIAPNTFEGfvhLEELDLGDNrQLRTL 116
Cdd:PRK15370 224 TLYANSNQLTSIPATLPDTIQEMELSINRITELPE-RLPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDN-SIRTL 298

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160  117 APETFQGLVKlhaLYLYKCGLSALPAGIFGGLHSLQylyLQDNHIEYLQDDIFVDLVNLS 176
Cdd:PRK15370 299 PAHLPSGITH---LNVQSNSLTALPETLPPGLKTLE---AGENALTSLPASLPPELQVLD 352
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-256 1.74e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 1.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160   82 WIY--SNNITFIAPNTFEGFVHLEELDLGDNrQLRTLAPETFQGLVKLHALYLYKCGLSA-LPAGIFGgLHSLQYLYLQD 158
Cdd:PLN00113 216 WIYlgYNNLSGEIPYEIGGLTSLNHLDLVYN-NLTGPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFS-LQKLISLDLSD 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160  159 NHIEYLQDDIFVDLVNLSHLFLHGNK-------------------LWS--LGQGIFRGL---VNLDRLLLHENQLQWVHH 214
Cdd:PLN00113 294 NSLSGEIPELVIQLQNLEILHLFSNNftgkipvaltslprlqvlqLWSnkFSGEIPKNLgkhNNLTVLDLSTNNLTGEIP 373

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 29244160  215 KAFHDLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGNA 256
Cdd:PLN00113 374 EGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNS 415
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 126-255 1.80e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 1.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 126 KLHALYLYKCGLSALPAgiFGGLHSLQYLYLQDNHIEYLQDdiFVDLVNLSHLFLHGNKlwslgqgIFR--GLVNLDRLL 203
Cdd:cd21340  25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR-------ISVveGLENLTNLE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 204 -LH-ENQ---------------------LQW--VHH------KAFHDLHRLTTLFLFNNSLTELQ--GDCLAPLVALEFL 250
Cdd:cd21340  94 eLHiENQrlppgekltfdprslaalsnsLRVlnISGnnidslEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLREL 173


                ....*
gi 29244160 251 RLNGN 255
Cdd:cd21340 174 DLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-255 3.82e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 3.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160   48 IPEGIPEDSERIF---LQNNRITFLQQGHFSPAMVTLWIYSNNITFIAPNTFEGFVHLEELDLGDNrQLRTLAPETFQGL 124
Cdd:PLN00113 109 IPDDIFTTSSSLRylnLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN-VLVGKIPNSLTNL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160  125 VKLHALYLYKCGLSALPAGIFGGLHSLQYLYLQDNHieyLQDDIFVD---LVNLSHLFLHGNKLW-----SLGQgifrgL 196
Cdd:PLN00113 188 TSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNN---LSGEIPYEiggLTSLNHLDLVYNNLTgpipsSLGN-----L 259

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 29244160  197 VNLDRLLLHENQLQWVHHKAFHDLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGN 255
Cdd:PLN00113 260 KNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 80-118 1.73e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.73e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 29244160    80 TLWIYSNNITFIAPntFEGFVHLEELDLGDNRQLRTLAP 118
Cdd:pfam12799   5 VLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
150-255 2.12e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 150 SLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGQGIFRGLVNLDRLLLHENqlqwvhhKAFHDLHRLTTLFLF 229
Cdd:COG4886  49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLS 121

                        90       100
                ....*....|....*....|....*.
gi 29244160 230 NNSLTELqGDCLAPLVALEFLRLNGN 255
Cdd:COG4886 122 GNQLTDL-PEELANLTNLKELDLSNN 146
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 150-187 5.17e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 5.17e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 29244160   150 SLQYLYLQDNHIEYLqdDIFVDLVNLSHLFLHGNKLWS 187
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNKIT 37
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 102-255 5.23e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 5.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 102 LEELDLGDN------RQLRtLAPETFQGLVKLHALYLYKCGLSALPAGIFGGLH---SLQYLYLQDNHIEYLQDDIFVD- 171
Cdd:cd00116  53 LKELCLSLNetgripRGLQ-SLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKg 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244160 172 ----LVNLSHLFLHGNKLWSLG----QGIFRGLVNLDRLLLHENQL--QWVHH--KAFHDLHRLTTLFLFNNSLTELQG- 238
Cdd:cd00116 132 lkdlPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIgdAGIRAlaEGLKANCNLEVLDLNNNGLTDEGAs 211

                       170       180
                ....*....|....*....|
gi 29244160 239 ---DCLAPLVALEFLRLNGN 255
Cdd:cd00116 212 alaETLASLKSLEVLNLGDN 231
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 222-255 8.31e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 8.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 29244160   222 RLTTLFLFNNSLTELQGdcLAPLVALEFLRLNGN 255
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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