Streptogramin lyase [Defense mechanisms];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593056   6 GPCWVGPGPDGGLAVSEEFGD-VRLFGSARqplGSLGGWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLF-PRAGPPIC 83
Cdd:COG4257  18 GPRDVAVDPDGAVWFTDQGGGrIGRLDPAT---GEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIdPKTGEITT 94

                        90       100       110
                ....*....|....*....|....*....|.
gi 60593056  84 LVSEGLG-QPLGVACAPQGQLLVADAKDNSI 113
Cdd:COG4257  95 FALPGGGsNPHGIAFDPDGNLWFTDQGGNRI 125

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593056   3 GLEGPCWVGPGPDGGLAVSEEFGD-VRLFGSARQPLGSLG--GWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAG 79
Cdd:cd05819 147 QFNGPTGVAVDSDGNIYVADTGNHrIQVFDPDGNFLTTFGstGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDG 226

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 60593056  80 PPIC------LVSEGLGQPLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd05819 227 AGFGgngnflGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 60593056  48 FGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVSE---GLGQ---PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd05819   7 LNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGNFITSFGSfgsGDGQfnePAGVAVDSDGNLYVADTGNHRIQKF 81

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593056   3 GLEGPCWVGPGPDGGLAVSEeFGDVRL--FGSARQPLGSLG--GWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRA 78
Cdd:cd14954 163 QLDSPRGVAVNPDGNIVVSD-FNNHRLqvFDPDGQFLRFFGseGSGNGQFKRPRGVAVDDEGNIIVADSGNHRVQVFSPD 241

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 60593056  79 GPPICLV---SEGLGQ---PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14954 242 GEFLCSFgteGNGEGQfdrPSGVAVTPDGRIVVVDRGNHRIQVF 285

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593056  38 GSLGGWTGHtFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPIC-LVSEGLG-----QPLGVACAPQGQLLVADaKDN 111
Cdd:cd14954  61 GSYGSRDGQ-FDRPAGVAVNSRGRIIVADKDNHRIQVFDLNGRFLLkFGERGTKngqfnYPWGVAVDSEGRIYVSD-TRN 138

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 60593056  45 GHTFGC---PAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVSE---GLGQ---PLGVACAPQGQLLVADaKDN 111
Cdd:cd14954  17 GSKDGElcrPWGVAVDKDGRIIVADRSNNRVQVFDPDGKFLRKFGSygsRDGQfdrPAGVAVNSRGRIIVAD-KDN 91

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 60593056  51 PAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVSEGLGQPLGVACAPQGQLLVADAKDNSI 113
Cdd:cd14961  60 PLDVAVTPDGHIVVTDAGDRSVKVFSFDGRLKLFVRKSFSLPWGVAVNPSGEILVTDSEAGKL 122

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593056   4 LEGPCWVGPGPDGGLAVSEEFGD-VRLFGSARQPL---GSLGGWTGHtFGCPAGICSNSEGNVIVADEQRRQVTLFPRAG 79
Cdd:cd14957 111 FNGPYGIAVDSNGNIYVADTGNHrIQVFTSSGTFSysiGSGGTGPGQ-FNGPQGIAVDSDGNIYVADTGNHRIQVFTSSG 189

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 60593056  80 PPICLV-SEG-----LGQPLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14957 190 TFQYTFgSSGsgpgqFSDPYGIAVDSDGNIYVADTGNHRIQVF 232

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593056  13 GPDGGLAVSEeFGDVRL--FGSARQPLGSLGG---WTGHtFGCPAGICSNSEGNVIVAD--EQRRQVtlFPRAGPPICLV 85
Cdd:cd14956 115 DADGNLYVAD-FGNQRIqkFDPDGSFLRQWGGtgiEPGS-FNYPRGVAVDPDGTLYVADtyNDRIQV--FDNDGAFLRKW 190

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 60593056  86 SE---GLGQ---PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14956 191 GGrgtGPGQfnyPYGIAIDPDGNVFVADFGNNRIQKF 227

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593056  15 DGGLAVSEEFGD-VRLFGSARQPLGSLGGWTGHT--FGCPAGICSNSEGNVIVADEQRRQVTLFPRAGP---PICLVSEG 88
Cdd:cd14957  28 AGNIYVADTGNNrIQVFTSSGVYSYSIGSGGTGSgqFNSPYGIAVDSNGNIYVADTDNNRIQVFNSSGVyqySIGTGGSG 107

                        90       100       110
                ....*....|....*....|....*....|.
gi 60593056  89 LGQ---PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14957 108 DGQfngPYGIAVDSNGNIYVADTGNHRIQVF 138

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 60593056  51 PAGICSNSEGNVIVADEQRRQVTLFPRAGPPI-CLVSEG-----LGQPLGVACAPQGQLLVADAKDNSIKV 115
Cdd:cd14954 120 PWGVAVDSEGRIYVSDTRNHRVQVFDSDGQFIrKFGFEGagpgqLDSPRGVAVNPDGNIVVSDFNNHRLQV 190

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 60593056  51 PAGICSNSEGNVIVADE-QRRQVTLFPRAGPPICLVSEGLGQPLGVACAPQGQLLVADAKDNSI 113
Cdd:cd14952  54 PQGVAVDAAGTVYVTDFgNNRVLKLAAGSTTQTVLPFTGLNDPTGVAVDAAGNVYVADTGNNRV 117

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 60593056  48 FGCPAGICSNSEGNVIVADEQRRQVTLFPRAGP-----PICLVSEGLGQPLGVACApQGQLLVADAKDNSIKVY 116
Cdd:cd14963  55 FKYPYGIAVDSDGNIYVADLYNGRIQVFDPDGKflkyfPEKKDRVKLISPAGLAID-DGKLYVSDVKKHKVIVF 127

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 60593056  51 PAGICSNSEGNVIVADE-QRRQVTLFPRAGPPICLVSEGLGQPLGVACAPQGQLLVADAKDN 111
Cdd:cd14952  12 PGGVAVDAAGNVYVADSgNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDAAGTVYVTDFGNN 73

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593056   7 PCWVGPGPDGGLAVSEEF-GDVRLFGSARQPLGSLG--GWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGP--- 80
Cdd:cd14962 150 PTDLAVDRDGNLYVTDTMnFRVQIFDADGKFLRSFGerGDGPGSFARPKGIAVDSEGNIYVVDAAFDNVQIFNPEGElll 229

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 60593056  81 PICLVSEGLGQ---PLGVACAPQGQLLVADAKDNSIKVYQ 117
Cdd:cd14962 230 TVGGPGSGPGEfylPSGIAIDKDDRIYVVDQFNRRIQVFQ 269

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 60593056  51 PAGICSNSEGNVIVADEQRRQV-TLFPRAGPPICLVSEGLGQPLGVACAPQGQLLVADAKDN 111
Cdd:cd14952  96 PTGVAVDAAGNVYVADTGNNRVlKLAAGSNTQTVLPFTGLSNPDGVAVDGAGNVYVTDTGNN 157

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20
                ....*....|....*....|....*
gi 60593056  92 PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14951 198 PLGVAALPDGSVYVADTYNHKIKRV 222

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593056  31 GSARQPLGSLGGWTGHtFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVS---EGLGQ---PLGVACAPQGQLL 104
Cdd:cd14956  43 GTFLRRFGTTGDGPGQ-FGRPRGLAVDKDGWLYVADYWGDRIQVFTLTGELQTIGGssgSGPGQfnaPRGVAVDADGNLY 121

                ....
gi 60593056 105 VADA 108
Cdd:cd14956 122 VADF 125

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593056  30 FGSARQPLGSLGGWTGHTFgcpagicsNSEGNVIVADEQRRQVTLFPRAGPPICLVSEG-LGQPLGVACAPQGQLLVADA 108
Cdd:cd14960  53 FGVRGRSPGQLQRPTGVAV--------TLNGDIIIADYDNKWVSIFSPDGKFKSKIGAGkLMGPKGVAVDRNGHIIVVDN 124

                ....*....
gi 60593056 109 KDNSIKVYQ 117
Cdd:cd14960 125 KACCVFIFQ 133

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593056  13 GPDGGLAVSE-EFGDVRLFGSARQPLGSLGGwtGHTFGCPAGICSNSEGNVI-VADEQRRQVTLFPRAGPpicLVS---- 86
Cdd:cd14962  65 DANGNLYVSDaELGKVFVFDRDGKFLRAIGA--GALFKRPTGIAVDPAGKRLyVVDTLAHKVKVFDLDGR---LLFdigk 139

                        90       100       110
                ....*....|....*....|....*....|....*
gi 60593056  87 --EGLGQ---PLGVACAPQGQLLVADAKDNSIKVY 116
Cdd:cd14962 140 rgSGPGEfnlPTDLAVDRDGNLYVTDTMNFRVQIF 174