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Conserved domains on  [gi|442624551|ref|NP_788433|]
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entomoglyceroporin 2, isoform C [Drosophila melanogaster]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
41-261 2.13e-51

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member pfam00230:

Pssm-ID: 444743 [Multi-domain]  Cd Length: 223  Bit Score: 168.26  E-value: 2.13e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551   41 RQLDSITTVLAEMIATAMLMFLGCmGSVEN-----SVFTNSDF-QSALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVY 114
Cdd:pfam00230   3 RSVSFLRAVIAEFLATLLFVFFGV-GSALGvkklvSSLAVSGLlAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  115 NMISLPMALAYFVAQMVGAFIGYGLLKAVlpesaiYSAENPNGVCLTSLNSTLTPWQGLAVEFLITCVLISVCCGVWDP- 193
Cdd:pfam00230  82 RRFSLLRAIFYIVAQLLGAIAGAALLYGV------TVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDr 155
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442624551  194 RNATKQDSLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGFWDDHWIYWVGPMAAALITSVIY 261
Cdd:pfam00230 156 RNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
41-261 2.13e-51

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 168.26  E-value: 2.13e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551   41 RQLDSITTVLAEMIATAMLMFLGCmGSVEN-----SVFTNSDF-QSALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVY 114
Cdd:pfam00230   3 RSVSFLRAVIAEFLATLLFVFFGV-GSALGvkklvSSLAVSGLlAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  115 NMISLPMALAYFVAQMVGAFIGYGLLKAVlpesaiYSAENPNGVCLTSLNSTLTPWQGLAVEFLITCVLISVCCGVWDP- 193
Cdd:pfam00230  82 RRFSLLRAIFYIVAQLLGAIAGAALLYGV------TVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDr 155
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442624551  194 RNATKQDSLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGFWDDHWIYWVGPMAAALITSVIY 261
Cdd:pfam00230 156 RNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
50-263 2.53e-51

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 168.20  E-value: 2.53e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  50 LAEMIATAMLMFLGCmGSVENSVFTNSDFQS----ALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMALAY 125
Cdd:cd00333    4 LAEFLGTFLLVFFGC-GSVLAVKLAGGASGGllgiALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIPY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 126 FVAQMVGAFIGYGLLKAVLPeSAIYSAENPNGVCLTSLNSTLTP----WQGLAVEFLITCVLISVCCGVWDPRN-ATKQD 200
Cdd:cd00333   83 IIAQLLGAILGAALLYGLYY-GLYLEFLGANNIVAGIFGTYPSPgvsnGNAFFVEFIGTFILVLVVFATTDDPNgPPPGG 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442624551 201 SLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGF---WDDHWIYWVGPMAAALITSVIYKH 263
Cdd:cd00333  162 LAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDY 227
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
50-266 4.30e-50

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 165.30  E-value: 4.30e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  50 LAEMIATAMLMFLGCmGSVenSVFTNSDFQS-----ALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMALA 124
Cdd:COG0580    7 LAEFLGTFILVLLGC-GVV--AVLAGTKGGIgwlgiALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVLP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 125 YFVAQMVGAFIGYGLLKAVLPE--SAIYSAENPNGVCLTSLNSTLTPWQGLAVEFLITCVLISVCCGVWDPRNATKQ-DS 201
Cdd:COG0580   84 YIIAQLLGAFLGAALVYLIYGGhfDATEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGGlAP 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442624551 202 LPVrfGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGF------WDDHWIYWVGPMAAALITSVIYKHAFR 266
Cdd:COG0580  164 LAI--GLLVAAIGLSLGPLTGYAINPARDLGPRLFHALgkggsdWGYLWVPIVAPILGAALAALLYRALFG 232
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
51-261 5.90e-44

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 148.99  E-value: 5.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551   51 AEMIATAMLMFLGCMGSVENSV------FTNSDFQS-ALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMAL 123
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVagaygaVGGGQFLGvALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  124 AYFVAQMVGAFIGYGLLKAVLpesaiYSAENPNGVCLTSLNSTLTPWQGLAVEFLITCVLISVCCGVWDPRNATKQDSL- 202
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLT-----SGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFa 155
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442624551  203 PVRFGLAIACLSLTAGQLTGASMNPVRSFAPAI--WNGFWDDHWIYWVGPMAAALITSVIY 261
Cdd:TIGR00861 156 PLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALfaGLAGWGNHWVYWVGPIIGAILGALVY 216
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
50-262 1.36e-27

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 108.29  E-value: 1.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  50 LAEMIATAMLMFLGcMGSVENSVF--TNSDFQS-ALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMALAYF 126
Cdd:PTZ00016  54 VAEFLGTFVLLFFG-EGVVATTHTvgNNGDYLAiTIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGYF 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 127 VAQMVGAFIG----YGLLKAVL-----PESAIYSAENPN-GVCLTSLNSTLTpwQGLAVEFLITCVLISVCCGVWDPRNA 196
Cdd:PTZ00016 133 VAQLLGAFVGaacvYGLYYGFFkdhgiPELPWETMANGFaGVFATYPREGNF--YAIFSELILTAILLLVILAITDPNNC 210
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442624551 197 TKQDSLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAI-----WNG--FWDDHWIYW---VGPMAAALITSVIYK 262
Cdd:PTZ00016 211 PAFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLfsailWGSevFTKDNYYFWvplVAPFVGAVLGMFLYD 286
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
41-261 2.13e-51

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 168.26  E-value: 2.13e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551   41 RQLDSITTVLAEMIATAMLMFLGCmGSVEN-----SVFTNSDF-QSALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVY 114
Cdd:pfam00230   3 RSVSFLRAVIAEFLATLLFVFFGV-GSALGvkklvSSLAVSGLlAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  115 NMISLPMALAYFVAQMVGAFIGYGLLKAVlpesaiYSAENPNGVCLTSLNSTLTPWQGLAVEFLITCVLISVCCGVWDP- 193
Cdd:pfam00230  82 RRFSLLRAIFYIVAQLLGAIAGAALLYGV------TVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDr 155
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442624551  194 RNATKQDSLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGFWDDHWIYWVGPMAAALITSVIY 261
Cdd:pfam00230 156 RNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
50-263 2.53e-51

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 168.20  E-value: 2.53e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  50 LAEMIATAMLMFLGCmGSVENSVFTNSDFQS----ALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMALAY 125
Cdd:cd00333    4 LAEFLGTFLLVFFGC-GSVLAVKLAGGASGGllgiALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIPY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 126 FVAQMVGAFIGYGLLKAVLPeSAIYSAENPNGVCLTSLNSTLTP----WQGLAVEFLITCVLISVCCGVWDPRN-ATKQD 200
Cdd:cd00333   83 IIAQLLGAILGAALLYGLYY-GLYLEFLGANNIVAGIFGTYPSPgvsnGNAFFVEFIGTFILVLVVFATTDDPNgPPPGG 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442624551 201 SLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGF---WDDHWIYWVGPMAAALITSVIYKH 263
Cdd:cd00333  162 LAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDY 227
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
50-266 4.30e-50

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 165.30  E-value: 4.30e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  50 LAEMIATAMLMFLGCmGSVenSVFTNSDFQS-----ALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMALA 124
Cdd:COG0580    7 LAEFLGTFILVLLGC-GVV--AVLAGTKGGIgwlgiALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVLP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 125 YFVAQMVGAFIGYGLLKAVLPE--SAIYSAENPNGVCLTSLNSTLTPWQGLAVEFLITCVLISVCCGVWDPRNATKQ-DS 201
Cdd:COG0580   84 YIIAQLLGAFLGAALVYLIYGGhfDATEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGGlAP 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442624551 202 LPVrfGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGF------WDDHWIYWVGPMAAALITSVIYKHAFR 266
Cdd:COG0580  164 LAI--GLLVAAIGLSLGPLTGYAINPARDLGPRLFHALgkggsdWGYLWVPIVAPILGAALAALLYRALFG 232
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
51-261 5.90e-44

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 148.99  E-value: 5.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551   51 AEMIATAMLMFLGCMGSVENSV------FTNSDFQS-ALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMAL 123
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVagaygaVGGGQFLGvALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  124 AYFVAQMVGAFIGYGLLKAVLpesaiYSAENPNGVCLTSLNSTLTPWQGLAVEFLITCVLISVCCGVWDPRNATKQDSL- 202
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLT-----SGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFa 155
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442624551  203 PVRFGLAIACLSLTAGQLTGASMNPVRSFAPAI--WNGFWDDHWIYWVGPMAAALITSVIY 261
Cdd:TIGR00861 156 PLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALfaGLAGWGNHWVYWVGPIIGAILGALVY 216
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
50-262 1.36e-27

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 108.29  E-value: 1.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  50 LAEMIATAMLMFLGcMGSVENSVF--TNSDFQS-ALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMALAYF 126
Cdd:PTZ00016  54 VAEFLGTFVLLFFG-EGVVATTHTvgNNGDYLAiTIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGYF 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 127 VAQMVGAFIG----YGLLKAVL-----PESAIYSAENPN-GVCLTSLNSTLTpwQGLAVEFLITCVLISVCCGVWDPRNA 196
Cdd:PTZ00016 133 VAQLLGAFVGaacvYGLYYGFFkdhgiPELPWETMANGFaGVFATYPREGNF--YAIFSELILTAILLLVILAITDPNNC 210
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442624551 197 TKQDSLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAI-----WNG--FWDDHWIYW---VGPMAAALITSVIYK 262
Cdd:PTZ00016 211 PAFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLfsailWGSevFTKDNYYFWvplVAPFVGAVLGMFLYD 286
PLN00166 PLN00166
aquaporin TIP2; Provisional
45-276 8.16e-26

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 102.32  E-value: 8.16e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  45 SITTVLAEMIATAMLMFLGCMGSVENSVFTNSD-------FQSALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMI 117
Cdd:PLN00166  17 SLKAYLSEFIATLLFVFAGVGSAIAFAKLTSDAaldpaglVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 118 SLPMALAYFVAQMVGAFIGYGLLKAvlpesaiysAENPNGVCLTSLNSTLTPWQGLAVEFLITCVLI-SVCCGVWDPRNA 196
Cdd:PLN00166  97 TIITGFFYWIAQCLGSIVACLLLVF---------VTNGESVPTHGVAAGLGAIEGVVMEIVVTFALVyTVYATAADPKKG 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 197 TKQDSLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGFWDDHWIYWVGPMAAALITSVIYKHAFRRELEESEVDE 276
Cdd:PLN00166 168 SLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVFIGSYAAAPTSE 247
PLN00027 PLN00027
aquaporin TIP; Provisional
42-265 5.33e-25

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 100.25  E-value: 5.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  42 QLDSITTVLAEMIATAMLMFLGCMGSVENSVFTNSD-------FQSALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVY 114
Cdd:PLN00027  16 HPDALKAALAEFISTLIFVFAGEGSGMAFNKLTDNGsttpaglVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIG 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 115 NMISLPMALAYFVAQMVGAFIGYGLLKAV---LPESAIysaenpngvcltSLNSTLTPWQGLAVEFLITCVLI-SVCCGV 190
Cdd:PLN00027  96 GNITLLRGILYWIAQLLGSVVACLLLKFStggLETSAF------------SLSSGVGVWNAFVFEIVMTFGLVyTVYATA 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442624551 191 WDPRNATKQDSLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGFWDDHWIYWVGPMAAALITSVIYKHAF 265
Cdd:PLN00027 164 VDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIF 238
PLN00026 PLN00026
aquaporin NIP; Provisional
51-283 5.46e-22

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 93.00  E-value: 5.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  51 AEMIATAMLMFLGCMGSVENSVFTNSD--FQSALNFGFVVLICIQCFGCVCGAHLNPAVTLATyvynmislpMALAYFVA 128
Cdd:PLN00026  76 AEFVGTFILIFAATAGPIVNQKYDGAEtlIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAF---------AALRHFPW 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 129 QMVGAFIGYGLLKAVLPESAIYSAENP---NGVCLTSLNSTltpwQGLAVEFLITCVLISVCCGV-WDPRNATKQDSLPV 204
Cdd:PLN00026 147 KHVPAYIAAQVSASICASFALKGVFHPfmsGGVTVPSVSTG----QAFALEFIITFNLLFVVTAVaTDTRAVGELAGIAV 222
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442624551 205 rfGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGFWDDHWIYWVGPMAAALITSVIYKHAFRRElEESEVDETTMSTKR 283
Cdd:PLN00026 223 --GATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLRE-EDGDPPRPVRSFRR 298
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
7-261 1.51e-21

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 91.51  E-value: 1.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551   7 QSAEIGHQMKMSSEEPPSGKQT--CRSQSNCWLLQRrqldsittVLAEMIATAMLMFLGCMGSVENSVFTNS-DFQS-AL 82
Cdd:PLN00182   9 EEEQISRIEKGNGKDSQGGIETaiCTSPSIVCLTQK--------LIAEMIGTYFIIFSGCGVVVVNVLYGGTiTFPGiCV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  83 NFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMALAYFVAQMVGAFIGYGLLK---AVLPESaiYSAENPNGvc 159
Cdd:PLN00182  81 TWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASLTLRlmfNVTPEA--FFGTTPTD-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 160 ltslnstlTPWQGLAVEFLITCVLISVCCGVWDPRNATKqDSLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGF 239
Cdd:PLN00182 157 --------SSGQALVAEIIISFLLMFVISGVATDSRAVG-ELAGIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGR 227
                        250       260
                 ....*....|....*....|..
gi 442624551 240 WDDHWIYWVGPMAAALITSVIY 261
Cdd:PLN00182 228 YKGIWVYIVGPFVGIIAGGFVY 249
PLN00184 PLN00184
aquaporin NIP1; Provisional
10-261 3.96e-20

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 88.15  E-value: 3.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  10 EIGHQMKMSS--EEPPSGKQTCRSQSNCWLLQRrqldsittVLAEMIATAMLMFLGCMGSVENSVFTNSDFQS--ALNFG 85
Cdd:PLN00184  24 EVEHQQEMEAihNPKPLKKQDSLLSVSVPFLQK--------LIAEVLGTYFLVFTGCASVVVNMQNDNVVTLPgiAIVWG 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  86 FVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMALAYFVAQMVGAFIGYGLLKAVLP-ESAIYSAENPNGVCLTSLN 164
Cdd:PLN00184  96 LTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGlDHDVCSGKHDVFIGSSPVG 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 165 STLtpwQGLAVEFLITCVLISVCCGVwdprnATKQDSLPVRFGLAIACLSL----TAGQLTGASMNPVRSFAPAIWNGFW 240
Cdd:PLN00184 176 SDL---QAFVMEFIVTFYLMFIISGV-----ATDNRAIGELAGLAIGSTVLlnvlIAAPVSSASMNPGRSLGPAMVYGCY 247
                        250       260
                 ....*....|....*....|.
gi 442624551 241 DDHWIYWVGPMAAALITSVIY 261
Cdd:PLN00184 248 KGIWIYIVAPTLGAIAGAWVY 268
PRK05420 PRK05420
aquaporin Z; Provisional
50-262 7.76e-19

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 83.09  E-value: 7.76e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  50 LAEMIATAMLMFLGCMGSVENSVFTNSDFQ---SALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMALAYF 126
Cdd:PRK05420   6 AAEFFGTFWLVFGGCGSAVLAAAFPELGIGflgVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELVPYI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 127 VAQMVGAFIGYGLL------KAVLPESAI------YSAENPNGVCLTSlnstltpwqGLAVEFLITCVLISVCCGVWDPR 194
Cdd:PRK05420  86 IAQVVGGIAAAAVLyliasgKAGFDLAGSgfasngYGEHSPGGYSLLA---------ALVCEVVLTAFFLLVILGATDKR 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 195 naTKQDSLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGFW--DDHWIYWVGPMAAALITSVIYK 262
Cdd:PRK05420 157 --APAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYR 224
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
43-262 6.61e-17

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 78.75  E-value: 6.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  43 LDSITTVLAEMIATAMLMFLGC--MGSVENSVFTNSDFQSALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLP 120
Cdd:PLN00183  42 LNPARMVLAEMVGTFILMFCVCgiIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWS 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 121 MALAYFVAQMVGAFIGYGLLKAVLPESAIYSAENPNGVCLTSLnstltpWQGLAVEFLITCVLISVCCGVWDPRNATKqd 200
Cdd:PLN00183 122 KVPLYITAQTVGSVLATYVGVSVYGVKADLMTTKPAQGCSSAF------WVEFIATFIVMFLAASLTSQPQSLGHLSG-- 193
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442624551 201 slpVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGFWDDHWIYWVGPMAAALITSVIYK 262
Cdd:PLN00183 194 ---FVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFH 252
PLN00167 PLN00167
aquaporin TIP5; Provisional
44-261 4.79e-16

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 76.10  E-value: 4.79e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551  44 DSITTVLAEMIATAMLMFlGCMGSVENSVFTNSDfQSALNFGFVVLICIQCFGC---------VCGAHLNPAVTLATYVY 114
Cdd:PLN00167  20 NALRSYLAEFISTFFFVF-AAVGSAMSSRKLMPD-AASDPSSLLIVAIANAFALssavyiaanISGGHVNPAVTFGMAVG 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 115 NMISLPMALAYFVAQMVGAFIGYGLLKAVLPEsaiysaenpNGVCLTSLNSTLTPWQGLAVEFLITCVLISVCCGVWDPR 194
Cdd:PLN00167  98 GHISVPTAMFYWISQMLASVMACLFLKVTTVG---------QHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPR 168
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442624551 195 NATKQDSLPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGFWDDHWIYWVGPMAAALITSVIY 261
Cdd:PLN00167 169 RGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLY 235
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
170-266 1.28e-03

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 39.34  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551 170 WQGLAVEFLITCVLISVCCGVWDPRNATKQDSLPVR----FGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGF-WDDHW 244
Cdd:COG0580    3 MKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGialaWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFpWKDVL 82
                         90       100
                 ....*....|....*....|....*.
gi 442624551 245 IYWV----GPMAAALITSVIYKHAFR 266
Cdd:COG0580   83 PYIIaqllGAFLGAALVYLIYGGHFD 108
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
49-136 5.47e-03

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 37.28  E-value: 5.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624551   49 VLAEMIATAMLMFLGCMGSVENSVFTNSDFqSALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVY-NMISLPMALAYFV 127
Cdd:TIGR00861 125 FFVEFIGTAILVLVIFATTDDRNRVPRGGF-APLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFaGLAGWGNHWVYWV 203

                  ....*....
gi 442624551  128 AQMVGAFIG 136
Cdd:TIGR00861 204 GPIIGAILG 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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