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Conserved domains on  [gi|295444868|ref|NP_780520|]
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zinc finger protein 513 isoform 1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473158)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Mus musculus zinc finger protein 513

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677|GO:0003700
PubMed:  11361095|22803940|30718982|10940247|12665246|11179890
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
402-425 1.09e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.09e-05
                          10        20
                  ....*....|....*....|....
gi 295444868  402 NLKRHQRVHTGEKPYKCPLCPYAC 425
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
414-487 1.17e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.17e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 295444868 414 KPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSM--NLKRHMLRHTGEKPFRCATCAYTTGHWDNY 487
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-217 2.69e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.69e-05
                          10        20
                  ....*....|....*....|....*.
gi 295444868  192 NLTRHTRTHTGEKPYRCPHCPFACSS 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-399 1.88e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 295444868  374 HLARHMKTHSGEKPFRCARCPYASAH 399
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-228 1.89e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.89e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 295444868 176 KPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFAC--SSLGNLRRHQRTH 228
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKsfSRPLELSRHLRTH 86
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
402-425 1.09e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.09e-05
                          10        20
                  ....*....|....*....|....
gi 295444868  402 NLKRHQRVHTGEKPYKCPLCPYAC 425
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
414-487 1.17e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.17e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 295444868 414 KPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSM--NLKRHMLRHTGEKPFRCATCAYTTGHWDNY 487
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-217 2.69e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.69e-05
                          10        20
                  ....*....|....*....|....*.
gi 295444868  192 NLTRHTRTHTGEKPYRCPHCPFACSS 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
372-450 3.82e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444868 372 PNHLARHMKTHSG-EKPFRCARCPYASAHLDNLKRHQR--VHTGE--KPYKCP--LCPYACGNLANLKRHGRIHSGDKPF 444
Cdd:COG5048  273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352


                 ....*.
gi 295444868 445 RCSLCN 450
Cdd:COG5048  353 KEKLLN 358
zf-H2C2_2 pfam13465
Zinc-finger double domain;
458-481 1.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.43e-04
                          10        20
                  ....*....|....*....|....
gi 295444868  458 NLKRHMLRHTGEKPFRCATCAYTT 481
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-399 1.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 295444868  374 HLARHMKTHSGEKPFRCARCPYASAH 399
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-228 1.89e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.89e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 295444868 176 KPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFAC--SSLGNLRRHQRTH 228
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKsfSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
164-189 2.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 295444868  164 HLKRHMQTHSGEKPFRCGRCPYASAQ 189
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
402-425 1.09e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.09e-05
                          10        20
                  ....*....|....*....|....
gi 295444868  402 NLKRHQRVHTGEKPYKCPLCPYAC 425
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
414-487 1.17e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.17e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 295444868 414 KPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSM--NLKRHMLRHTGEKPFRCATCAYTTGHWDNY 487
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-217 2.69e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.69e-05
                          10        20
                  ....*....|....*....|....*.
gi 295444868  192 NLTRHTRTHTGEKPYRCPHCPFACSS 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
372-450 3.82e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444868 372 PNHLARHMKTHSG-EKPFRCARCPYASAHLDNLKRHQR--VHTGE--KPYKCP--LCPYACGNLANLKRHGRIHSGDKPF 444
Cdd:COG5048  273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352


                 ....*.
gi 295444868 445 RCSLCN 450
Cdd:COG5048  353 KEKLLN 358
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
354-477 1.07e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444868 354 GPGDKGFAC--SLCPFATHYPNHLARHMKTHSGEKPFRC--ARCPYASAHLDNLKRHQRV--HTGEKPYKCPLCPYACGN 427
Cdd:COG5048  316 GESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCI 395

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 295444868 428 LANLKRHGRI-----HSGDKP--FRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATC 477
Cdd:COG5048  396 RNFKRDSNLSlhiitHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452
zf-H2C2_2 pfam13465
Zinc-finger double domain;
458-481 1.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.43e-04
                          10        20
                  ....*....|....*....|....
gi 295444868  458 NLKRHMLRHTGEKPFRCATCAYTT 481
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-399 1.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 295444868  374 HLARHMKTHSGEKPFRCARCPYASAH 399
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-228 1.89e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.89e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 295444868 176 KPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFAC--SSLGNLRRHQRTH 228
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKsfSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
164-189 2.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 295444868  164 HLKRHMQTHSGEKPFRCGRCPYASAQ 189
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
357-458 3.47e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444868 357 DKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAH--LDNLKRHQRVHTGEKPYKCPlcpyACGNLANLKrh 434
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNS----KSLPLSNSK-- 104

                         90       100
                 ....*....|....*....|....
gi 295444868 435 griHSGDKPFRCSLCNYSCNQSMN 458
Cdd:COG5048  105 ---ASSSSLSSSSSNSNDNNLLSS 125
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
444-468 1.55e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 35.99  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....*
gi 295444868  444 FRCSLCNYSCNQSMNLKRHMLRHTG 468
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
430-455 2.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 295444868  430 NLKRHGRIHSGDKPFRCSLCNYSCNQ 455
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 206-228 3.32e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.32e-03
                          10        20
                  ....*....|....*....|...
gi 295444868  206 YRCPHCPFACSSLGNLRRHQRTH 228
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
414-474 6.73e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 6.73e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 295444868 414 KPYKCPLCPYACGNLANLKRH--GRIHSG--DKPFRC--SLCNYSCNQSMNLKRHMLRHTGEKPFRC 474
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE 354
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
388-412 8.08e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.06  E-value: 8.08e-03
                          10        20
                  ....*....|....*....|....*
gi 295444868  388 FRCARCPYASAHLDNLKRHQRVHTG 412
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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