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Conserved domains on  [gi|116174774|ref|NP_780464|]
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protein transport protein Sec24A isoform 1 [Mus musculus]

Protein Classification

SEC24 family transport protein( domain architecture ID 1001573)

SEC24 family transport protein is a component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG5028 super family cl34873
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
295-1090 1.52e-179

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5028:

Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 546.70  E-value: 1.52e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  295 PGYQnSAPPVAGMPPPSLSYPSgpQAFTQTPLGANHLTASMSglslhpeglrvvnllqernmlpstPLQPPVPNLLEDIQ 374
Cdd:COG5028    92 PYGG-SMADGTAPKPTNPLVPV--DLFEDQPPPISDLFLPPP------------------------PIVPPLTTNFVGSE 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  375 KLNCNPELFRCTLTSVPQTQALLNKAKLPLGLLLHPFKDLV----QLPVVTSSTIVRCRSCRTYINPFVNFLDQ-RRWKC 449
Cdd:COG5028   145 QSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRC 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  450 NLCYRVNDVPEEFmYNPLTRV--YGEPHKRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAIETGYLNSVCQSLL 527
Cdd:COG5028   225 NICRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAIL 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  528 DNLDLLPG-NTRTKIGFITFDSTIHFYSLQEGLSQpQMLIVSDIDDVFIPMPENLLV-NLNESKELVQDLLKTLPQMFTK 605
Cdd:COG5028   304 ENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPSGLFVlPLKSCKQIIETLLDRVPRIFQD 382
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  606 TLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRssakeiHLTPSTDFYKKLALDCSGQQAAVD 685
Cdd:COG5028   383 NKSPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS------LLSCKDSFYKEFAIECSKVGISVD 456
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  686 LFLLSGQYSDLASLGCISRYSAGSVYYYPSYHhQHNPVQVQKLQKELHRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFV 765
Cdd:COG5028   457 LFLTSEDYIDVATLSHLCRYTGGQTYFYPNFS-ATRPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFN 535
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  766 RSTDLLSLPNVNPDAGYAVQMSVEESLTdTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGADVQAISGLLA 845
Cdd:COG5028   536 RSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILA 614
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  846 NMAVDRSVTASLSDARDALVNAVIDSLSAYRSSVLSGQQPGLMV-PFSLRLFPLFVLALLKQKSFQTGtSIRLDERIFAM 924
Cdd:COG5028   615 KKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPlPANLKLLPLLMLALLKSSAFRSG-STPSDIRISAL 693
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  925 CQVKSQPLVHLMLTTHPSLYRVDNLSDEGALNINDRTI-PQPpiLQLSVEKLSRDGAFLMDAGSLLMLWVGRNCSQNFLS 1003
Cdd:COG5028   694 NRLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVlPSP--INATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQ 771
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774 1004 QVLGVQNYASIPQTMTDLPELDTPESARIAAFISWLREQRPFF-PVLYVIRE--ESLMKAAFLQSLVEDRTESALSYYEF 1080
Cdd:COG5028   772 DLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDDStLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDY 851
                         810
                  ....*....|
gi 116174774 1081 LLHIQQQVNK 1090
Cdd:COG5028   852 LQILHEKIKS 861
PHA03247 super family cl33720
large tegument protein UL36; Provisional
5-367 7.92e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 7.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774    5 RIPAARGAAASLQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGsyPRPMPAKTlnpfsaqsnyggsqgsgq 84
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP--PTPEPAPH------------------ 2713
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   85 tlnsPLVTSGPVLPSLHSGPVPRMPLPTSqnPAATPMPSGSFLPGANPPPPlnwqynypsTGPQTNHFPHVAPPTLP-GN 163
Cdd:PHA03247 2714 ----ALVSATPLPPGPAAARQASPALPAA--PAPPAVPAGPATPGGPARPA---------RPPTTAGPPAPAPPAAPaAG 2778
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  164 PNLTADHQYVSSGDPALQTSFKKPGSALPLQNPPLPPTFQPGAPPGPPPAGGPPPSRGPAPQKTPPRAAPPPSFNSAVNQ 243
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  244 EG-ITSNANNGSTAAHNTYDEIEGGGFLATPQLVNQ-NPKTSRSVGSAYPSLPPGYQNSAPPVAGMPPPSLSYPSGPQAF 321
Cdd:PHA03247 2859 GGdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRStESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 116174774  322 TQTPLGANHLTASMSGLSLHPEGLRVVNLLQERNMLPSTPLQPPVP 367
Cdd:PHA03247 2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
295-1090 1.52e-179

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 546.70  E-value: 1.52e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  295 PGYQnSAPPVAGMPPPSLSYPSgpQAFTQTPLGANHLTASMSglslhpeglrvvnllqernmlpstPLQPPVPNLLEDIQ 374
Cdd:COG5028    92 PYGG-SMADGTAPKPTNPLVPV--DLFEDQPPPISDLFLPPP------------------------PIVPPLTTNFVGSE 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  375 KLNCNPELFRCTLTSVPQTQALLNKAKLPLGLLLHPFKDLV----QLPVVTSSTIVRCRSCRTYINPFVNFLDQ-RRWKC 449
Cdd:COG5028   145 QSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRC 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  450 NLCYRVNDVPEEFmYNPLTRV--YGEPHKRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAIETGYLNSVCQSLL 527
Cdd:COG5028   225 NICRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAIL 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  528 DNLDLLPG-NTRTKIGFITFDSTIHFYSLQEGLSQpQMLIVSDIDDVFIPMPENLLV-NLNESKELVQDLLKTLPQMFTK 605
Cdd:COG5028   304 ENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPSGLFVlPLKSCKQIIETLLDRVPRIFQD 382
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  606 TLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRssakeiHLTPSTDFYKKLALDCSGQQAAVD 685
Cdd:COG5028   383 NKSPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS------LLSCKDSFYKEFAIECSKVGISVD 456
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  686 LFLLSGQYSDLASLGCISRYSAGSVYYYPSYHhQHNPVQVQKLQKELHRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFV 765
Cdd:COG5028   457 LFLTSEDYIDVATLSHLCRYTGGQTYFYPNFS-ATRPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFN 535
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  766 RSTDLLSLPNVNPDAGYAVQMSVEESLTdTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGADVQAISGLLA 845
Cdd:COG5028   536 RSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILA 614
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  846 NMAVDRSVTASLSDARDALVNAVIDSLSAYRSSVLSGQQPGLMV-PFSLRLFPLFVLALLKQKSFQTGtSIRLDERIFAM 924
Cdd:COG5028   615 KKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPlPANLKLLPLLMLALLKSSAFRSG-STPSDIRISAL 693
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  925 CQVKSQPLVHLMLTTHPSLYRVDNLSDEGALNINDRTI-PQPpiLQLSVEKLSRDGAFLMDAGSLLMLWVGRNCSQNFLS 1003
Cdd:COG5028   694 NRLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVlPSP--INATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQ 771
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774 1004 QVLGVQNYASIPQTMTDLPELDTPESARIAAFISWLREQRPFF-PVLYVIRE--ESLMKAAFLQSLVEDRTESALSYYEF 1080
Cdd:COG5028   772 DLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDDStLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDY 851
                         810
                  ....*....|
gi 116174774 1081 LLHIQQQVNK 1090
Cdd:COG5028   852 LQILHEKIKS 861
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
498-740 2.19e-128

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 390.48  E-value: 2.19e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  498 PQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGN-TRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIP 576
Cdd:cd01479     1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  577 MPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRS 656
Cdd:cd01479    81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  657 SAKE-IHLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSyHHQHNPVQVQKLQKELHRY 735
Cdd:cd01479   161 TDKEkQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPS-FNFSAPNDVEKLVNELARY 239

                  ....*
gi 116174774  736 LTRKI 740
Cdd:cd01479   240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
498-736 1.23e-104

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 327.67  E-value: 1.23e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   498 PQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIPM 577
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   578 PENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLI--SPTGGRMSVFQTQLPTLGV-GALKPREEPNQ 654
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   655 RSSAKE-IHLTPSTD-FYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHnpvQVQKLQKEL 732
Cdd:pfam04811  161 HGTDKEkAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237

                   ....
gi 116174774   733 HRYL 736
Cdd:pfam04811  238 QRYF 241
PTZ00395 PTZ00395
Sec24-related protein; Provisional
463-1090 3.72e-49

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 191.06  E-value: 3.72e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  463 MYNPLTRVYGEPHKRPEVQNATIEFMAPSEYMLrppqPPVYLFVFDVSHNAIetgyLNSVCQSLLDNLDLLPGNTR---T 539
Cdd:PTZ00395  919 MKNLICEKNGEPDSAKIRRNSFLAKYPQVKNML----PPYFVFVVECSYNAI----YNNITYTILEGIRYAVQNVKcpqT 990
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  540 KIGFITFDSTIHFYSLQEGLSQP-------------QMLIVSDIDDVFIPMP-ENLLVNLNESKELVQDLLKTLPQMFTK 605
Cdd:PTZ00395  991 KIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSVSTT 1070
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  606 TLETQSALGPALQAAFKLISPTGGRMSV--FQTQLPTLGVGALKPREEPNQRSSAKeihlTPSTDFYKKLALDCSGQQAA 683
Cdd:PTZ00395 1071 MQSYGSCGNSALKIAMDMLKERNGLGSIcmFYTTTPNCGIGAIKELKKDLQENFLE----VKQKIFYDSLLLDLYAFNIS 1146
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  684 VDLFLLSGQYSDLA--SLGCISRYSAGSVYYYPSYHHQHNpvqVQKLQKELHRYLTRK-IGFEAVMRIRCTKGLSIHTF- 759
Cdd:PTZ00395 1147 VDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENFLWQKD---YKEIYMNIMDTLTSEdIAYCCELKLRYSHHMSVKKLf 1223
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  760 --HGNF-FVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGAD 836
Cdd:PTZ00395 1224 ccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTD 1303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  837 VQAisglLANMAVDRSVTASLSDarDALVNAVIDSLSA----YR----SSVLSGQqpgLMVPFSLRLFPLFVLALLKQKS 908
Cdd:PTZ00395 1304 AEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRincaSSAHSGQ---LILPDTLKLLPLFTSSLLKHNV 1374
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  909 fqTGTSIRLDERIFAMCQVKSQPLVHLMLTTHPSLY--RVDNLSDE-GALNIND-----RTIPQppilqlSVEKLSRDGA 980
Cdd:PTZ00395 1375 --TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDdlfipKTIPS------SAEKIYSNGI 1446
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  981 FLMDAGSLLMLWVGRNCSQNFLSQVLGvqnyaSIP--QTMTDLPELDTPESARIAAFISWLREQRPF--FPVLYVIREES 1056
Cdd:PTZ00395 1447 YLLDACTHFYLYFGFHSDANFAKEIVG-----DIPteKNAHELNLTDTPNAQKVQRIIKNLSRIHHFnkYVPLVMVAPKS 1521
                         650       660       670
                  ....*....|....*....|....*....|....
gi 116174774 1057 LMKAAFLQSLVEDRTESALSYYEFLLHIQQQVNK 1090
Cdd:PTZ00395 1522 NEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
PHA03247 PHA03247
large tegument protein UL36; Provisional
5-367 7.92e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 7.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774    5 RIPAARGAAASLQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGsyPRPMPAKTlnpfsaqsnyggsqgsgq 84
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP--PTPEPAPH------------------ 2713
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   85 tlnsPLVTSGPVLPSLHSGPVPRMPLPTSqnPAATPMPSGSFLPGANPPPPlnwqynypsTGPQTNHFPHVAPPTLP-GN 163
Cdd:PHA03247 2714 ----ALVSATPLPPGPAAARQASPALPAA--PAPPAVPAGPATPGGPARPA---------RPPTTAGPPAPAPPAAPaAG 2778
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  164 PNLTADHQYVSSGDPALQTSFKKPGSALPLQNPPLPPTFQPGAPPGPPPAGGPPPSRGPAPQKTPPRAAPPPSFNSAVNQ 243
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  244 EG-ITSNANNGSTAAHNTYDEIEGGGFLATPQLVNQ-NPKTSRSVGSAYPSLPPGYQNSAPPVAGMPPPSLSYPSGPQAF 321
Cdd:PHA03247 2859 GGdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRStESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 116174774  322 TQTPLGANHLTASMSGLSLHPEGLRVVNLLQERNMLPSTPLQPPVP 367
Cdd:PHA03247 2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
16-180 1.58e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 1.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774    16 LQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGSYPRPMPAKTLNPFSAQSnyggsqgSGQTLNSPLvtsgp 95
Cdd:pfam03154  174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQ-------QTPTLHPQR----- 241
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774    96 vLPSLHSG--PVPRMPLPTSQNPAATPMPSgsfLPGANPPPPLNWQynypsTGPqtNHFPHVAPPTLPGNPNLTADHQYV 173
Cdd:pfam03154  242 -LPSPHPPlqPMTQPPPPSQVSPQPLPQPS---LHGQMPPMPHSLQ-----TGP--SHMQHPVPPQPFPLTPQSSQSQVP 310

                   ....*..
gi 116174774   174 SSGDPAL 180
Cdd:pfam03154  311 PGPSPAA 317
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
295-1090 1.52e-179

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 546.70  E-value: 1.52e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  295 PGYQnSAPPVAGMPPPSLSYPSgpQAFTQTPLGANHLTASMSglslhpeglrvvnllqernmlpstPLQPPVPNLLEDIQ 374
Cdd:COG5028    92 PYGG-SMADGTAPKPTNPLVPV--DLFEDQPPPISDLFLPPP------------------------PIVPPLTTNFVGSE 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  375 KLNCNPELFRCTLTSVPQTQALLNKAKLPLGLLLHPFKDLV----QLPVVTSSTIVRCRSCRTYINPFVNFLDQ-RRWKC 449
Cdd:COG5028   145 QSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRC 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  450 NLCYRVNDVPEEFmYNPLTRV--YGEPHKRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAIETGYLNSVCQSLL 527
Cdd:COG5028   225 NICRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAIL 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  528 DNLDLLPG-NTRTKIGFITFDSTIHFYSLQEGLSQpQMLIVSDIDDVFIPMPENLLV-NLNESKELVQDLLKTLPQMFTK 605
Cdd:COG5028   304 ENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPSGLFVlPLKSCKQIIETLLDRVPRIFQD 382
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  606 TLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRssakeiHLTPSTDFYKKLALDCSGQQAAVD 685
Cdd:COG5028   383 NKSPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS------LLSCKDSFYKEFAIECSKVGISVD 456
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  686 LFLLSGQYSDLASLGCISRYSAGSVYYYPSYHhQHNPVQVQKLQKELHRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFV 765
Cdd:COG5028   457 LFLTSEDYIDVATLSHLCRYTGGQTYFYPNFS-ATRPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFN 535
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  766 RSTDLLSLPNVNPDAGYAVQMSVEESLTdTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGADVQAISGLLA 845
Cdd:COG5028   536 RSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILA 614
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  846 NMAVDRSVTASLSDARDALVNAVIDSLSAYRSSVLSGQQPGLMV-PFSLRLFPLFVLALLKQKSFQTGtSIRLDERIFAM 924
Cdd:COG5028   615 KKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPlPANLKLLPLLMLALLKSSAFRSG-STPSDIRISAL 693
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  925 CQVKSQPLVHLMLTTHPSLYRVDNLSDEGALNINDRTI-PQPpiLQLSVEKLSRDGAFLMDAGSLLMLWVGRNCSQNFLS 1003
Cdd:COG5028   694 NRLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVlPSP--INATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQ 771
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774 1004 QVLGVQNYASIPQTMTDLPELDTPESARIAAFISWLREQRPFF-PVLYVIRE--ESLMKAAFLQSLVEDRTESALSYYEF 1080
Cdd:COG5028   772 DLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDDStLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDY 851
                         810
                  ....*....|
gi 116174774 1081 LLHIQQQVNK 1090
Cdd:COG5028   852 LQILHEKIKS 861
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
498-740 2.19e-128

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 390.48  E-value: 2.19e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  498 PQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGN-TRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIP 576
Cdd:cd01479     1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  577 MPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRS 656
Cdd:cd01479    81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  657 SAKE-IHLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSyHHQHNPVQVQKLQKELHRY 735
Cdd:cd01479   161 TDKEkQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPS-FNFSAPNDVEKLVNELARY 239

                  ....*
gi 116174774  736 LTRKI 740
Cdd:cd01479   240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
498-736 1.23e-104

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 327.67  E-value: 1.23e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   498 PQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIPM 577
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   578 PENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLI--SPTGGRMSVFQTQLPTLGV-GALKPREEPNQ 654
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   655 RSSAKE-IHLTPSTD-FYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHnpvQVQKLQKEL 732
Cdd:pfam04811  161 HGTDKEkAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237

                   ....
gi 116174774   733 HRYL 736
Cdd:pfam04811  238 QRYF 241
trunk_domain cd01468
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ...
498-734 1.13e-100

trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.


Pssm-ID: 238745 [Multi-domain]  Cd Length: 239  Bit Score: 317.26  E-value: 1.13e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  498 PQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIPM 577
Cdd:cd01468     1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKDVFLPL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  578 PENLLVNLNESKELVQDLLKTLPQMFTK--TLETQSALGPALQAAFKLISPT--GGRMSVFQTQLPTLGVGALKPREEPN 653
Cdd:cd01468    81 PDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTfaGGRIIVFQGGLPTVGPGKLKSREDKE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  654 QRSSAKE-IHLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHqhnPVQVQKLQKEL 732
Cdd:cd01468   161 PIRSHDEaQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQA---PNDGSKFKQDL 237

                  ..
gi 116174774  733 HR 734
Cdd:cd01468   238 QR 239
PTZ00395 PTZ00395
Sec24-related protein; Provisional
463-1090 3.72e-49

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 191.06  E-value: 3.72e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  463 MYNPLTRVYGEPHKRPEVQNATIEFMAPSEYMLrppqPPVYLFVFDVSHNAIetgyLNSVCQSLLDNLDLLPGNTR---T 539
Cdd:PTZ00395  919 MKNLICEKNGEPDSAKIRRNSFLAKYPQVKNML----PPYFVFVVECSYNAI----YNNITYTILEGIRYAVQNVKcpqT 990
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  540 KIGFITFDSTIHFYSLQEGLSQP-------------QMLIVSDIDDVFIPMP-ENLLVNLNESKELVQDLLKTLPQMFTK 605
Cdd:PTZ00395  991 KIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSVSTT 1070
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  606 TLETQSALGPALQAAFKLISPTGGRMSV--FQTQLPTLGVGALKPREEPNQRSSAKeihlTPSTDFYKKLALDCSGQQAA 683
Cdd:PTZ00395 1071 MQSYGSCGNSALKIAMDMLKERNGLGSIcmFYTTTPNCGIGAIKELKKDLQENFLE----VKQKIFYDSLLLDLYAFNIS 1146
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  684 VDLFLLSGQYSDLA--SLGCISRYSAGSVYYYPSYHHQHNpvqVQKLQKELHRYLTRK-IGFEAVMRIRCTKGLSIHTF- 759
Cdd:PTZ00395 1147 VDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENFLWQKD---YKEIYMNIMDTLTSEdIAYCCELKLRYSHHMSVKKLf 1223
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  760 --HGNF-FVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGAD 836
Cdd:PTZ00395 1224 ccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTD 1303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  837 VQAisglLANMAVDRSVTASLSDarDALVNAVIDSLSA----YR----SSVLSGQqpgLMVPFSLRLFPLFVLALLKQKS 908
Cdd:PTZ00395 1304 AEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRincaSSAHSGQ---LILPDTLKLLPLFTSSLLKHNV 1374
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  909 fqTGTSIRLDERIFAMCQVKSQPLVHLMLTTHPSLY--RVDNLSDE-GALNIND-----RTIPQppilqlSVEKLSRDGA 980
Cdd:PTZ00395 1375 --TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDdlfipKTIPS------SAEKIYSNGI 1446
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  981 FLMDAGSLLMLWVGRNCSQNFLSQVLGvqnyaSIP--QTMTDLPELDTPESARIAAFISWLREQRPF--FPVLYVIREES 1056
Cdd:PTZ00395 1447 YLLDACTHFYLYFGFHSDANFAKEIVG-----DIPteKNAHELNLTDTPNAQKVQRIIKNLSRIHHFnkYVPLVMVAPKS 1521
                         650       660       670
                  ....*....|....*....|....*....|....
gi 116174774 1057 LMKAAFLQSLVEDRTESALSYYEFLLHIQQQVNK 1090
Cdd:PTZ00395 1522 NEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
Sec23_BS pfam08033
Sec23/Sec24 beta-sandwich domain;
741-825 2.30e-32

Sec23/Sec24 beta-sandwich domain;


Pssm-ID: 429794 [Multi-domain]  Cd Length: 86  Bit Score: 120.72  E-value: 2.30e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   741 GFEAVMRIRCTKGLSIHTFHGNFFVRS-TDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHT 819
Cdd:pfam08033    1 GFNAVLRVRTSKGLKVSGFIGNFVSRSsGDTWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80

                   ....*.
gi 116174774   820 LCLPVV 825
Cdd:pfam08033   81 VALPVT 86
Sec23_helical pfam04815
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ...
836-937 2.57e-32

Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.


Pssm-ID: 461441 [Multi-domain]  Cd Length: 103  Bit Score: 121.07  E-value: 2.57e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   836 DVQAISGLLANMAVDRSVTASLSDARDALVNAVIDSLSAYRSSVLSGQQPG-LMVPFSLRLFPLFVLALLKQKSFQTGTS 914
Cdd:pfam04815    1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGqLILPESLKLLPLYMLALLKSPALRGGNS 80
                           90       100
                   ....*....|....*....|...
gi 116174774   915 IRLDERIFAMCQVKSQPLVHLML 937
Cdd:pfam04815   81 SPSDERAYARHLLLSLPVEELLL 103
zf-Sec23_Sec24 pfam04810
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
425-461 3.95e-16

Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.


Pssm-ID: 461437 [Multi-domain]  Cd Length: 38  Bit Score: 72.86  E-value: 3.95e-16
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 116174774   425 IVRCRSCRTYINPFVNFLDQ-RRWKCNLCYRVNDVPEE 461
Cdd:pfam04810    1 PVRCRRCRAYLNPFCQFDFGgKKWTCNFCGTRNPVPPE 38
PLN00162 PLN00162
transport protein sec23; Provisional
384-555 7.81e-16

transport protein sec23; Provisional


Pssm-ID: 215083 [Multi-domain]  Cd Length: 761  Bit Score: 82.68  E-value: 7.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  384 RCTLTSVPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIvRCRSCRTYINPF--VNFlDQRRWKCNLCYRVNDVPEE 461
Cdd:PLN00162   13 RMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPL-RCRTCRAVLNPYcrVDF-QAKIWICPFCFQRNHFPPH 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  462 FMYNPLTRVYGE--PhkrpevQNATIEFMAPSEYMLRPPqPPVYLFVFDVSHNAIETGYLNSvcqSLLDNLDLLPGNTRt 539
Cdd:PLN00162   91 YSSISETNLPAElfP------QYTTVEYTLPPGSGGAPS-PPVFVFVVDTCMIEEELGALKS---ALLQAIALLPENAL- 159
                         170
                  ....*....|....*.
gi 116174774  540 kIGFITFDSTIHFYSL 555
Cdd:PLN00162  160 -VGLITFGTHVHVHEL 174
SEC23 COG5047
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
384-859 2.20e-15

Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];


Pssm-ID: 227380 [Multi-domain]  Cd Length: 755  Bit Score: 81.08  E-value: 2.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  384 RCTLTSVPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVNFLDQRR-WKCNLCYRVNDVPEEF 462
Cdd:COG5047    13 RLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKCTAPCKAVLNPYCHIDERNQsWICPFCNQRNTLPPQY 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  463 MYNPLTRVYGEPHKrpevQNATIEFMAPseymlRPPQ-PPVYLFVFDVshnAIETGYLNSVCQSLLDNLDLLPGNTRtkI 541
Cdd:COG5047    93 RDISNANLPLELLP----QSSTIEYTLS-----KPVIlPPVFFFVVDA---CCDEEELTALKDSLIVSLSLLPPEAL--V 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  542 GFITFDSTIHF----------------------YSLQE--GLSQPQMLIV--SDIDDVFIPMPENLLVNLNESKELVQDL 595
Cdd:COG5047   159 GLITYGTSIQVhelnaenhrrsyvfsgnkeytkENLQEllALSKPTKSGGfeSKISGIGQFASSRFLLPTQQCEFKLLNI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  596 LKTL---PQMFTKTLETQSALGPALQAAFKLIS----PTGGRMSVFQTQLPTLGVGALKPRE--EPnQRS-----SAKEI 661
Cdd:COG5047   239 LEQLqpdPWPVPAGKRPLRCTGSALNIASSLLEqcfpNAGCHIVLFAGGPCTVGPGTVVSTElkEP-MRShhdieSDSAQ 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  662 HLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQK-LQKELHRYLtrKI 740
Cdd:COG5047   318 HSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSIFKQSFQRiFNRDSEGYL--KM 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  741 GFEAVMRIRCTKGLSIHTFHGN---------------FFVRSTDLLSLPNVNPDAGYAV------QMSVEESLTDTQ-LV 798
Cdd:COG5047   396 GFNANMEVKTSKNLKIKGLIGHavsvkkkannisdseIGIGATNSWKMASLSPKSNYALyfeialGAASGSAQRPAEaYI 475
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116174774  799 SFQSalLYTSSKGERRIRVHTLCLPVVSTLNEVFLGA-DVQAISGLLANMAVDRSVTASLSD 859
Cdd:COG5047   476 QFIT--TYQHSSGTYRIRVTTVARMFTDGGLPKINRSfDQEAAAVFMARIAAFKAETEDIID 535
Gelsolin pfam00626
Gelsolin repeat;
961-1036 3.67e-11

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 60.01  E-value: 3.67e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116174774   961 TIPQPPILQLSVEKLSRDGAFLMDAGSLLMLWVGRNcsQNFLSQVLGVQNYASIPQTM-TDLPELDT-PESARIAAFI 1036
Cdd:pfam00626    1 KFVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKG--SSLLEKLFAALLAAQLDDDErFPLPEVIRvPQGKEPARFL 76
Sec23-like cd01478
Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
498-687 4.55e-05

Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 23 is very similar to Sec24. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup lack the consensus MIDAS motif but have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238755 [Multi-domain]  Cd Length: 267  Bit Score: 46.60  E-value: 4.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  498 PQPPVYLFVFDVSHNAIETGYLNSvcqSLLDNLDLLPGNTRtkIGFITFDSTIHFYSL---------------------- 555
Cdd:cd01478     1 TSPPVFLFVVDTCMDEEELDALKE---SLIMSLSLLPPNAL--VGLITFGTMVQVHELgfeecsksyvfrgnkdytakqi 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  556 --QEGLSQPQM----LIVSDIDDVFIPMPEN-LLVNLNESKELVQDLLKTL---PQMFTKTLETQSALGPALQAAFKLIS 625
Cdd:cd01478    76 qdMLGLGGPAMrpsaSQHPGAGNPLPSAAASrFLLPVSQCEFTLTDLLEQLqpdPWPVPAGHRPLRCTGVALSIAVGLLE 155
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116174774  626 P----TGGRMSVFQTQLPTLGVGALKPREEPNQRSSAKEI------HLTPSTDFYKKLALDCSGQQAAVDLF 687
Cdd:cd01478   156 AcfpnTGARIMLFAGGPCTVGPGAVVSTELKDPIRSHHDIdkdnakYYKKAVKFYDSLAKRLAANGHAVDIF 227
PHA03247 PHA03247
large tegument protein UL36; Provisional
5-367 7.92e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 7.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774    5 RIPAARGAAASLQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGsyPRPMPAKTlnpfsaqsnyggsqgsgq 84
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP--PTPEPAPH------------------ 2713
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   85 tlnsPLVTSGPVLPSLHSGPVPRMPLPTSqnPAATPMPSGSFLPGANPPPPlnwqynypsTGPQTNHFPHVAPPTLP-GN 163
Cdd:PHA03247 2714 ----ALVSATPLPPGPAAARQASPALPAA--PAPPAVPAGPATPGGPARPA---------RPPTTAGPPAPAPPAAPaAG 2778
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  164 PNLTADHQYVSSGDPALQTSFKKPGSALPLQNPPLPPTFQPGAPPGPPPAGGPPPSRGPAPQKTPPRAAPPPSFNSAVNQ 243
Cdd:PHA03247 2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  244 EG-ITSNANNGSTAAHNTYDEIEGGGFLATPQLVNQ-NPKTSRSVGSAYPSLPPGYQNSAPPVAGMPPPSLSYPSGPQAF 321
Cdd:PHA03247 2859 GGdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRStESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 116174774  322 TQTPLGANHLTASMSGLSLHPEGLRVVNLLQERNMLPSTPLQPPVP 367
Cdd:PHA03247 2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
16-180 1.58e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 1.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774    16 LQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGSYPRPMPAKTLNPFSAQSnyggsqgSGQTLNSPLvtsgp 95
Cdd:pfam03154  174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQ-------QTPTLHPQR----- 241
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774    96 vLPSLHSG--PVPRMPLPTSQNPAATPMPSgsfLPGANPPPPLNWQynypsTGPqtNHFPHVAPPTLPGNPNLTADHQYV 173
Cdd:pfam03154  242 -LPSPHPPlqPMTQPPPPSQVSPQPLPQPS---LHGQMPPMPHSLQ-----TGP--SHMQHPVPPQPFPLTPQSSQSQVP 310

                   ....*..
gi 116174774   174 SSGDPAL 180
Cdd:pfam03154  311 PGPSPAA 317
PHA03247 PHA03247
large tegument protein UL36; Provisional
2-372 2.58e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774    2 AQPRIPAARGAAASLQAQNGAASASGSPYTNGPVHNTlmSPQVsssqgydsqPPGSYPRPMPAKTLNPFSAQSNYGGSQG 81
Cdd:PHA03247 2734 ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA--PPAA---------PAAGPPRRLTRPAVASLSESRESLPSPW 2802
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774   82 SGQTLNSPLVTSGPVLPSlHSGPVPRMPLPTSQNPAATPMPSGSflpganPPPPLNWQYNYPSTGPQTNHFPHVAPPTLP 161
Cdd:PHA03247 2803 DPADPPAAVLAPAAALPP-AASPAGPLPPPTSAQPTAPPPPPGP------PPPSLPLGGSVAPGGDVRRRPPSRSPAAKP 2875
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  162 GNPNltadHQYVSS-GDPALQTSFKKpgSALPLQNPPLPPTFQPGAPPGPPPAGGPPPSRGPAPQkTPPRAAPPPSFNSA 240
Cdd:PHA03247 2876 AAPA----RPPVRRlARPAVSRSTES--FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP-PPPRPQPPLAPTTD 2948
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774  241 vnqegiTSNANNGSTAAHNTYDEIEGGGFLATPQLVNQNPKTSRSVGSayPSLPPGYQNSAPPVAGMpPPSLSY----PS 316
Cdd:PHA03247 2949 ------PAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPA--SSTPPLTGHSLSRVSSW-ASSLALheetDP 3019
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 116174774  317 GPQAFTQT---PLGANHLTASMSGLSlHPEGLRVVNLLQERNMLPSTPLQPPVPNLLED 372
Cdd:PHA03247 3020 PPVSLKQTlwpPDDTEDSDADSLFDS-DSERSDLEALDPLPPEPHDPFAHEPDPATPEA 3077
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
7-135 6.65e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 6.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174774    7 PAARGAAASLQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGSYPRPMPAKTLNPFSAQSNYGGSQGSGQTL 86
Cdd:PHA03307  334 ESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPR 413
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 116174774   87 NSPLVTSGPvlpslHSGPVPRMPLPtsqnpaatpMPSGSFLPGANPPPP 135
Cdd:PHA03307  414 PSPLDAGAA-----SGAFYARYPLL---------TPSGEPWPGSPPPPP 448
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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