WD40 repeat [General function prediction only];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936 160 ARGNGTQPVLAGNGEDTIRLGVPVDPRKVLIVAGHHNWIVAAYAHFAVcyRIKESSGWQQVFTSPYLDWTIERVALNakv 239
Cdd:COG2319  55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV--RLWDLATGLLLRTLTGHTGAVRSVAFS--- 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936 240 vggPHGdkdKMVAVASE-SSIILWSVQDGG-----SGSEIGVFSLGVPVDalffiGNQLVATSHTGKVGVWNAVTQHWQV 313
Cdd:COG2319 130 ---PDG---KTLASGSAdGTVRLWDLATGKllrtlTGHSGAVTSVAFSPD-----GKLLASGSDDGTVRLWDLATGKLLR 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936 314 -----QDVVPITSYDTAGSFLLLGCNNGSIYYIDMqkfplrmkDNDLLVTELYHDpsNDAVTALSVyltpktSVSGNWie 388
Cdd:COG2319 199 tltghTGAVRSVAFSPDGKLLASGSADGTVRLWDL--------ATGKLLRTLTGH--SGSVRSVAF------SPDGRL-- 260

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27369936 389 IAYGTSSGAVRVIvqhpeTVGSGpQLFQTFTVHRSPVTKIMLS--EKHLVSVCADNNhVRTWTV 450
Cdd:COG2319 261 LASGSADGTVRLW-----DLATG-ELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGT-VRLWDL 317

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936    20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRT--KELDLRGVSINVLRHEA 97
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTggKLHRPEEVCLDEFLEEA 80

                  ....*...
gi 27369936    98 EFYGITPL 105
Cdd:pfam02214  81 EFYGLDEL 88

WD40 repeat [General function prediction only];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936 160 ARGNGTQPVLAGNGEDTIRLGVPVDPRKVLIVAGHHNWIVAAYAHFAVcyRIKESSGWQQVFTSPYLDWTIERVALNakv 239
Cdd:COG2319  55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV--RLWDLATGLLLRTLTGHTGAVRSVAFS--- 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936 240 vggPHGdkdKMVAVASE-SSIILWSVQDGG-----SGSEIGVFSLGVPVDalffiGNQLVATSHTGKVGVWNAVTQHWQV 313
Cdd:COG2319 130 ---PDG---KTLASGSAdGTVRLWDLATGKllrtlTGHSGAVTSVAFSPD-----GKLLASGSDDGTVRLWDLATGKLLR 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936 314 -----QDVVPITSYDTAGSFLLLGCNNGSIYYIDMqkfplrmkDNDLLVTELYHDpsNDAVTALSVyltpktSVSGNWie 388
Cdd:COG2319 199 tltghTGAVRSVAFSPDGKLLASGSADGTVRLWDL--------ATGKLLRTLTGH--SGSVRSVAF------SPDGRL-- 260

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27369936 389 IAYGTSSGAVRVIvqhpeTVGSGpQLFQTFTVHRSPVTKIMLS--EKHLVSVCADNNhVRTWTV 450
Cdd:COG2319 261 LASGSADGTVRLW-----DLATG-ELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGT-VRLWDL 317

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  17 GEIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDLRGVSINVLRHE 96
Cdd:cd18392   1 GEIIQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISSLKDETGAIFIDRDPTAFVPILNFLRTKELDLRGVNINVLRHE 80

                ....*...
gi 27369936  97 AEFYGITP 104
Cdd:cd18392  81 AEFYGITP 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDL--RGVSINVLRHEA 97
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLpsDFVELEELLAEA 80

                ...
gi 27369936  98 EFY 100
Cdd:cd18316  81 EFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  18 EIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDLRG--VSINVLRH 95
Cdd:cd18365   1 DIVNLNVGGVHYTTTLATLTRFPDSMLGAMFSGSMPTTRDDQGNYFIDRDGTLFRYILNFLRSSQLSLPEdfKEYDLLLR 80

                        90
                ....*....|....
gi 27369936  96 EAEFYGITPLVRRL 109
Cdd:cd18365  81 EADFYQIEPLIEAL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLM-WIPDSFFSSLLS--GRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDL-RGVSINVLRH 95
Cdd:cd18368   3 IKLNVGGRIFTTTRSTLVkKEPDSMLARMFSddSTWPSSRDENGAYLIDRSPEYFEPILNYLRHGQLILnDGLNPLGVLE 82

                        90
                ....*....|....
gi 27369936  96 EAEFYGITPLVRRL 109
Cdd:cd18368  83 EAKFFGIQSLIEIL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGR-ISTLRDETGAIFIDRDPAAFAPILNFLR------TKELDLRGVsinv 92
Cdd:cd18391   3 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEeLQSDRDETGAYLIDRDPTYFGPILNFLRhgklvlDKDMAEEGV---- 78

                        90
                ....*....|....*
gi 27369936  93 lRHEAEFYGITPLVR 107
Cdd:cd18391  79 -LEEAEFYNIGPLIR 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDL--RGVSINVLRHEA 97
Cdd:cd18394   5 VTLNVGGHLYTTSLSTLTRYPDSMLGAMFRGDFPTARDSQGNYFIDRDGPLFRYILNFLRTSELTLpvDFKEFDLLRKEA 84

                        90
                ....*....|..
gi 27369936  98 EFYGITPLVRRL 109
Cdd:cd18394  85 DFYQIEPLIQCL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLS-GRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDL-RGVSINVLRHEA 97
Cdd:cd18187   1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKpGREFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCpDGISIPDLREEC 80

                ...
gi 27369936  98 EFY 100
Cdd:cd18187  81 DFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLSG--RISTLRDETGAIFIDRDPAAFAPILNFLR------TKELDLRGVsin 91
Cdd:cd18389   3 VRLNVGGTYFVSTKQTLCRDPKSFLYRLCQEdpDLDSDKDETGAYLIDRDPTYFGPILNYLRhgkliiNKELAEEGV--- 79

                        90
                ....*....|....*.
gi 27369936  92 vlRHEAEFYGITPLVR 107
Cdd:cd18389  80 --LEEAEFYNIASLVR 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  19 IVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDL-RGVSIN-VLRHE 96
Cdd:cd18364   1 LVTLNVGGYLYITQRQTLTKYPDSFLEGMVNGKIQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLpEGFQENqLLALE 80

                ....*.
gi 27369936  97 AEFYGI 102
Cdd:cd18364  81 ADFYQL 86

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936     20 VQLNVGGTRFSTSRQTLMWIPDsFFSSLLSGRIStLRDETGAIFIDRDPAAFAPILNFLRTKELDLRGVSINVLRHEAEF 99
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSP-YFKALFSSDFK-ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*
gi 27369936    100 YGITPLVRrllLCEE 114
Cdd:smart00225  80 LQIPGLVE---LCEE 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLSG----RISTLRDETGAIFIDRDPAAFAPILNFLRTKELDL-RGVS-INVL 93
Cdd:cd18370   1 VTLNVGGTLYSTTLETLTRFPDSMLGAMFRAgtpiPPNLNMQGGGHYFIDRDGKAFRHILNFLRLGRLDLpRGYGeTALL 80

                ....*..
gi 27369936  94 RHEAEFY 100
Cdd:cd18370  81 RAEADFY 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGA-IFIDRDPAAFAPILNFLRTKELDLRG--VSINVLRHE 96
Cdd:cd18361   1 VHIDVGGHIYTSSLETLTKYPESRLGKLFNGSIPIVLDSLKQhYFIDRDGKMFRHILNFLRTSKLLLPDdfTEFDLLYEE 80

                        90
                ....*....|...
gi 27369936  97 AEFYGITPLVRRL 109
Cdd:cd18361  81 ARYYELQPMVKQL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  18 EIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGR-ISTL-RDETGAIFIDRDPAAFAPILNFLRTKELDL--RGVSINVL 93
Cdd:cd18396   4 EVVELNVGGQVYVTKHSTLLSVPDSTLASMFSRRaARELpRDNRGRFFIDRDGFLFRYVLDYLRDKQLALpdHFPEKERL 83

                        90
                ....*....|....*.
gi 27369936  94 RHEAEFYGITPLVRRL 109
Cdd:cd18396  84 LREAEYFQLGDLVKLL 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLR--DETGAIFIDRDPAAFAPILNFLRTKEL----DLRGvsiNVL 93
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEASAFDydPVTGEFFFDRHPGVFAQILNYYRTGKLhcpaDVCG---PLF 77

                        90
                ....*....|
gi 27369936  94 RHEAEFYGIT 103
Cdd:cd18379  78 EEELAFWGID 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  18 EIVQLNVGGTRFSTSRQTLMWIPDSFFSSllSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDL-RGVSINVLRHE 96
Cdd:cd18417  35 EILVVNVSGRRFQTWKNTLDRYPDTLLGS--SEKEFFYNEDTQEYFFDRDPEMFRHILNFYRTGRLHYpRHECIQAFDEE 112

                ....*...
gi 27369936  97 AEFYGITP 104
Cdd:cd18417 113 LSFYGIIP 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMwIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLR--TKELDLRGVSINVLRHEA 97
Cdd:cd18369   1 VKLNVGGSLHYTTIGTLT-KQDTMLRAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRdgSVPLPESRRELAELLAEA 79

                ....*....
gi 27369936  98 EFYGITPLV 106
Cdd:cd18369  80 KYYLVQGLV 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  18 EIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTL----RDETGAIFIDRDPAAFAPILNFLRTKELDL------RG 87
Cdd:cd18398   3 EVVELNVGGQVYFTRHATLVSIPHSLLWKMFSPKRDTAndlaKDSKGRFFIDRDGFLFRYILDYLRDRQVVLpdhfpeKG 82

                        90       100
                ....*....|....*....|..
gi 27369936  88 vsinVLRHEAEFYGITPLVRRL 109
Cdd:cd18398  83 ----RLKREAEYFQLPDLVKLL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  22 LNVGGTRFSTSRQTLMWIPDSFFSSllSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDL-RGVSINVLRHEAEFY 100
Cdd:cd18380   4 INVSGRRFETWKNTLEKYPDTLLGS--TEKEFFYDDDTKEYFFDRDPEIFRHILNFYRTGKLHYpRHECISAYDDELAFF 81

                ....
gi 27369936 101 GITP 104
Cdd:cd18380  82 GILP 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 10 (KCTD10); KCTD10, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (BACURD3), is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. Furthermore, KCTD10 may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD10 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMwIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDL--RGVSINVLRHEA 97
Cdd:cd18399   9 VKLNVGGALYYTTMQTLT-KQDTMLKAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGAVPLpeSRREIEELLAEA 87

                ....*....
gi 27369936  98 EFYGITPLV 106
Cdd:cd18399  88 KYYLVQGLV 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGrISTLRDETGAIFIDRDPAAFAPILNFLRTKELDL-RGVSINVLRHEAE 98
Cdd:cd18416   4 VVLNVGGIRHETYKATLKKIPATRLSRLTEA-LANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYpTDVCGPLFEEELE 82

                ....
gi 27369936  99 FYGI 102
Cdd:cd18416  83 FWGL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  18 EIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRD---ETGAIFIDRDPAAFAPILNFLRTKELDLRG-VSINVL 93
Cdd:cd18414   3 DRIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSNFDydpRADEFFFDRHPGVFAHILNYYRTGKLHCPAdVCGPLY 82

                ....*....
gi 27369936  94 RHEAEFYGI 102
Cdd:cd18414  83 EEELAFWGI 91

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  23 NVGGTRFSTSRQTLMWIPDSFfssLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDLRGVS-INVLRHEAEFYG 101
Cdd:cd18373   4 NVGGWIFSVPKSKLAQFPDSL---LWKEASSLSESENTRLFIDRDGFTFRHVHYYLQTSKLSSSSCSeLNLLYEQAAGLQ 80

                ....*...
gi 27369936 102 ITPLVRRL 109
Cdd:cd18373  81 LTSLLQAL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGR----ISTLRD----ETGAIFIDRDPAAFAPILNFLRTKELDL-RGVSI 90
Cdd:cd18382   1 VIINVGGARYSLPWSTLDRFPLTRLSRLKACRseddILRVCDdydvERNEFFFDRSPEAFGVILLFLRAGKLRLlREMCA 80

                        90
                ....*....|..
gi 27369936  91 NVLRHEAEFYGI 102
Cdd:cd18382  81 LSFQEELAYWGI 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGR----ISTLRDETGAI----FIDRDPAAFAPILNFLRTKELDLRG-VSI 90
Cdd:cd18427   2 ISINVGGFKKRLRSHTLLRFPETRLGRLLSCRskesILELCDDYDDTknefYFDRNPELFPYVLHFYNTGKLHVMGeLCV 81

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 27369936  91 NVLRHEAEFYGITplvrrlllceELERSSCGSVLFH 126
Cdd:cd18427  82 FSFSQEIEYWGIN----------EFFIDSCCSYSYH 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  22 LNVGGTRFSTSRQTLMWIPDSFFSSL-LSGRISTLR--DETGAI----FIDRDPAAFAPILNFLRTKEL----DLRGVSi 90
Cdd:cd18424   3 INVGGSRFVLSQQVLSSHPETRLGKLaVSVRDSVLElcDDANFVdneyFFDRSSQAFKYIMNYYKTGHLhvmeELCAIS- 81

                        90
                ....*....|....*
gi 27369936  91 nvLRHEAEFYGITPL 105
Cdd:cd18424  82 --FLQEIEYWGIDEL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369936  20 VQLNVGGTRFSTSRQTLMWIPDSFFSSLLS----GRISTLRDETGAI----FIDRDPAAFAPILNFLRTKELD-LRGVSI 90
Cdd:cd18426   1 ININVGGLKRRLSSSTLSKFPDTRLGRLLScdseESILQICDDYDVSakefYFDRNPGLFPYVLHFYQTGKLHiMEELCV 80