NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|25143253|ref|NP_740900|]
View 

Vacuolar protein sorting-associated protein 13 [Caenorhabditis elegans]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 136-373 2.39e-86

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


:

Pssm-ID: 465309  Cd Length: 234  Bit Score: 282.61  E-value: 2.39e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    136 FTEKMITQIIKNLQISVSNIHVRFEDRYTNRHRPFAMGITLEKLNFKTTDENWRETIHKDVVKIIYKLVSLQNLAIYWNS 215
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    216 STEFISDLD--DKEAIRKKLQETIHNGKNGPEGYNYILEPIQMEAKLKLNQKPETDgsnwKIPKIDLAVDMHALSIAIGK 293
Cdd:pfam16908   81 DSESLELLGdlDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE----TIPKIDLDLEFDEIGLTLDD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    294 FQYQDVLLFLEAQERFNAAGQYLKYRPNLNEfKGHYKAWWKFAYTSILEEKVRRRRnNWSWDRMQKHRQLVRKYQKAWVR 373
Cdd:pfam16908  157 RQYRDILSLLDSFHRFLRRQKYRKYRPKVSV-KENPRAWWKYAINAVLEEIRERRR-KWSWDYIKKRRDDRKEYIELYKK 234
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
4-2154 1.66e-74

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 278.69  E-value: 1.66e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    4 ESLVADLLNRFLGDFVDNLDSSQLNIGIWGGDVKLDNLQVKETALDDFDLPIKLKYGYLSSLVLKIPWKNLYNEPVIATV 83
Cdd:COG5043    3 EGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   84 DGLNLIVVPNKGVVYNEEKVAKNIQEIKQKTLARLEEARKERRK----PKDPQADTFTEKMITQIIKNLQISVSNIHVRF 159
Cdd:COG5043   83 EDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWEILRETLEEssssPNISRKQSFIESLITKLIDNIQIYIEDIHLRF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  160 EDRYTN-RHRPFAMGITLEKLNFKTTDENWRETIHKDVVKIIYKLVSLQNLAIYWNSSTEFISDLDDKEAI--RKKLQET 236
Cdd:COG5043  163 EDNLSAdLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEISPCITTEDIDSYLenFQPMIAE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  237 IHNGKNgpegyNYILEPIQMEAKLKLNQKPeTDgsnwKIPKIDLAVDMHALSIAIGKFQYQDVLLFLEAQERFNAAGQYL 316
Cdd:COG5043  243 KSPAYN-----EYILKPVRGTAKVSINKLP-TD----EIPRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  317 KYRPNlNEFKGHYKAWWKFAYTSILEEkVRRRRNNWSWDRMQKHRQLVRKYQKAWVRRQTEASPGADVQ--ATIKEAEKK 394
Cdd:COG5043  313 KYRPK-STPKEKPLEWFKYIILVVLDS-IHEKRYHWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSkeLEKRELTYD 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  395 LDVFNVNVARQQAEleidREGLTRQEDKPTGWVAWGKSWfgggggptPDKKKGAKDIGSqfqEAMTPEEKAKLFEAIDYQ 474
Cdd:COG5043  391 LIKYRSRLFRSLAK----RRNSIYLKPQTHKLQGWFSGL--------WNGKPQAQDEDT---LASTDKTAAELTDQEQKD 455

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  475 ENI---PPTNYPKEFVENKFDFKLGQVAIVVDG------AVSMQLLKLVASVeQRPSASAMHV--ESSIQELRMDGC--- 540
Cdd:COG5043  456 FFSeiePVGQLYSDTVNLDVEVSIAKGSFVIQKhirkinLISQRFENFKSKF-SLNKLDLFDGatNPELKPYRSIRNkpk 534

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  541 -----GTEIIRVRDPSIPWMSFLLdtNPLKGNYDQLVKLAVAPINIKYQAPAINNAIDVFKPP----ESVRlnQLTALAM 611
Cdd:COG5043  535 vreseSLQEIEEESRTHLFASFED--SKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPSrtkiEHVS--EWVYSAA 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  612 SRYEEVKARSATGLAYAVEHRSRLVLDVQIQPARIYVSEGGTySSEKPTLLADMGLLSVVT--VDNSSVDTSGmnKMAAL 689
Cdd:COG5043  611 ATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPEDCT-DPKSPTLFLDAGRISIHSqlVEDAIIKKFR--ELQTL 687

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  690 MEKAYDRFHVKLSNVVIAFAENVEtAENCVFEKESPLHVLKPTGLDIQIHKSSIDDL-KLAKMRVIGDLPNIVIGISDDR 768
Cdd:COG5043  688 ENLMYDRFTISLFNVRCLIGPDYE-GKRELPKGKCDYHILKELKLEINVEISILPKAtNLPKIKVSGHMPHASLMFSDVQ 766

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  769 LIGLMKL-GLSIPTPKADE-----KTKAEKELEVPVAKIKDRAKmrtimeveemeedvtqkeeggdddEKEKKKKTSEQQ 842
Cdd:COG5043  767 YKVIINLmSNILPTISVDEingdyQQFSSASLPPPFFDIKDNFQ------------------------IENHANEQTAAK 822

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  843 VqIELDLRLNQIGVVVY-------RKDAVFCDVSI--LKMACKLQMRTFDMVVTAELGSIKIsMPEFKSLDEKREHLYLI 913
Cdd:COG5043  823 F-HAQQIFAFYFKVDYFicsgldsRSENYLVPVLRarLEFYFDLVARKFNLRVTSNSNDIVD-KEFTYPSSLCDNLLSRS 900

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  914 DNDELQGALMTLKFVQANPESPFFATEYALTEQSVDFRFTKLAVSLHQEGVLELKAFGEALQAQLNELQKNTPE----EK 989
Cdd:COG5043  901 SPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFTSPNDEYMIGEDpeltRK 980

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  990 KVEETARKISRKlsdSVMSIASMSRTPSGKekrQRKKTVGSATQEMDVSRNIKQRIKASFGSLALMigtqkhletslaie 1069
Cdd:COG5043  981 ISDVENIKIEDA---NVRLDNNDIFLYDCI---QLFATVLSYGAFMHMEEREKFFLQLRLMDLELK-------------- 1040

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1070 ninanvkitekamevvatlraISMKDRTPGAVYKKLLSVTGKEdmlrfdfvqyQRTDEQRALMKSSDVDMVVKMRLAQMR 1149
Cdd:COG5043 1041 ---------------------NHEKSNNPDSTIVKIDDNKLFI----------FKYESYDIPDPITDCDCVLDISTGSLH 1089

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1150 FVFLNLWLarlmAWLAPFQN-EAVLAAQAAQAAAAEKAATAAQNVKQIMEQSPPRIQLDVILEApfivvprlSTSRDVIV 1228
Cdd:COG5043 1090 FYFIESYF----NFLSKFKRfKVSFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGE--------RNCRMQLI 1157

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1229 LHLGRLALKNeirgdseyPKAIID---RMDILMTDCSFGMGVMNEDVSAVSSSCLILKPISFKLALQRNLTfaVAKELPE 1305
Cdd:COG5043 1158 IKPGSFYAFS--------KCPVVEknsKLSIFSCELRKGEFSTAVPSSGHHDVLLEELNIHLDLTIDANPT--TGENAYV 1227

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1306 IVVDAHIHSIEAEMSDADYkTLMQTLSGNLAEGADLAippppppsslesSNTAAALTSPGKEKEKKDREANA----GPPV 1381
Cdd:COG5043 1228 FKATGDLDPVILNLCQSQH-LILLDLIDVVTTFFRID------------SSFSTSENLPRELDSEFDRSGTPvklkHSKK 1294

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1382 IEKSHTRIVFQFVLDKISAVLYEGEAVNGERKESDAFAALrLKNVKTSGKIGEDNSIVFAMSLDAFTMDDERKEKT-KIS 1460
Cdd:COG5043 1295 TVVETLDILFTFKLPKIRLNLYTGTFGIHGGDLTGLHNIL-FFEIGLDYGFYSSGTVYAEFSIASFRIEDVNPIKDvVFL 1373

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1461 KLMDKKGSKDDRFLDMSFNQDaEANKQIRLKMSAFFICLCPEFLGCLTRFFNVPQSE---------EQLEKQAVTANVPT 1531
Cdd:COG5043 1374 DVIEYSTNTHNLLVNGCLEYD-SQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAyyshldylvEQEYFNMGNPNQVA 1452

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1532 KAVSASPSASSTFTGGTKTssgppqpvgTLAIDCDMHGVEVILVEDsmhpestQALILSFNVTAASHPNEQTKDTKMNVA 1611
Cdd:COG5043 1453 CGEESYKLYRITIVDTTLV---------FVRDASDMNSYAIPFFFG-------QFLVTQQSIFTVTANNMGIFACKMSET 1516

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1612 VENLTI---FSSYYQSSRRNEVTYQVLTPVRIEALvnmnterkttdaVLKMSALDIKMSPSIIRLLSAVSAEFSKSSAPG 1688
Cdd:COG5043 1517 ANINQLlddFGIRFTISQHCSEKIQIITTLDFDSL------------LLRISVNDFLLLQTILRRIYNFIYALYDKETTD 1584

                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1689 ETGSISQKaaklrkwpnyFDSKPIDHRkywFFAApvaqeaveeeLDVTQEDKSRTDSMIGKESAKVDIERISFTLEAGTG 1768
Cdd:COG5043 1585 EELEKRTK----------DGQLALNPD---FLAA----------SVPTAQPSSVFGIRLCSEEFLINVDGIRLILISDLH 1641

                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1769 AIPVpLIFLDMLVNAEAYDWSSAMRVSSGVSVQMSYYNESVSVWEPIIEPvenekgeferWKLAMTMksrnkqdsSDSSP 1848
Cdd:COG5043 1642 DLPL-LDINIKPFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLEP----------WKVGVHI--------SRNDS 1702

                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1849 QTEVKIEADKMLNVTVTKSLLSLLNKLSEVFATAAkqitPTKTRHLPGISPFVVLNETGISVKVlDTETIRVSENgQAVD 1928
Cdd:COG5043 1703 KTAVHVFSREIADIVLTPRLIATLHFIFTKLISTP----FPIERKCDAPYRIVNYTQTAVSVWA-QFENAADSVE-CVRH 1776

                       2010      2020      2030      2040      2050      2060      2070      2080
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1929 ATHGEFVDVFLKNrKSDVEDRRLSIEQEEITG-DLKFELAGTVRETKIGRAEKRVIHLPRVSDGGHKWLIVAETTVENSR 2007
Cdd:COG5043 1777 LPNNTSTPWKFEE-WRQMQDVVSQDQDRVYIGvHVSNSKYESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNI 1855

                       2090      2100      2110      2120      2130      2140      2150      2160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2008 RLVTLNShvkftnhlsyAVEIYSKRDTTLDLF---GTVEHGETI----PLA---VPLLFSPSGDIYLKPV-DDKYEVSFE 2076
Cdd:COG5043 1856 KHITLRS----------PLLIINETQTEIEVVfcdSDGIQRSQIyhisPEEscsLPIETAYLYSIRIRPVsEDKFNWSSQ 1925

                       2170      2180      2190      2200      2210      2220      2230      2240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2077 SLCWHNFEHNRRQAVRCEAD-STDGSFSGIYIDSVVHEEKIQDGIDDQTTS------IYHVHLHPPLEFHNNL-PFDINI 2148
Cdd:COG5043 1926 AISWKSLVDNQQSIVTCLRQhSRDNTWSTPSCKFVGLHVVANDELYSLVIVnehdlpLMKLDSGADLEVKGVLlLKGVGI 2005


                 ....*.
gi 25143253 2149 ELPEQK 2154
Cdd:COG5043 2006 SLIDRK 2011
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 2803-2982 1.49e-67

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


:

Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 226.27  E-value: 1.49e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2803 KSFYNDLHISPIMMHLSFSQGGTSGDVAASgvsmpIQSEMINVLLRSVGVTLTELQDVVFKLAYFERKCVFYSPEQLNSE 2882
Cdd:pfam16909    1 KIYFELLHLQPIKLHLSFSRSERVNLEESL-----EKSNPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNR 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2883 IISHYAKQFIKQVYVLVLGLDIIGNPFGLVRDLSAGVEDLFYQPFQGAIQGPEEFAAGVALGVQSMFGHAVGGAAGAVGR 2962
Cdd:pfam16909   76 IQKHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSK 155

                          170       180
                   ....*....|....*....|
gi 25143253   2963 ITGTVGKGVAALTFDDDYMK 2982
Cdd:pfam16909  156 ITGSIGKGLAALTMDKQYQQ 175
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
2684-3177 5.98e-38

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 158.12  E-value: 5.98e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2684 KINHIQIDNQLDACIFPRVLsvVPPPKSVIV-DNTPKPFIELSLLQRQPEFSSIAEIEYGHVLIQEFSVQVDQGLINALL 2762
Cdd:COG5043 2039 ECAWVQIDNQLVLGIYPVIL--YPTEISQEEkEIENHLLPSRKFAVVKDSDSAVTYDKYVTILLQELSIELDEDLALAYL 2116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2763 LLISGEVTRKPYGKeMFDEDIKICHVTLSETASTYrsqrpksFYNDLHISPIMMHLSFSQggtsgDVAASGVSMPIQSEM 2842
Cdd:COG5043 2117 EKLKFPGSKYMDDK-KFDDEIELPDIIINKSGSNI-------YFEFLHLQPTRLHISFSR-----SSESSGEDGKVVPSS 2183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2843 INVLLRSV--GVTLTELQDVVFKLAYFERKCVFYSPEQLNSEIISHYAKQFIKQVYVLVLGLDIIGNPFGLVRDLSAGVE 2920
Cdd:COG5043 2184 NSYSDFYGmlAMTLGNINDAPVRLNSLLMDNARVSLPELFDLIASHYLQQVEYQIYKILGSADFLGNPVGLFETVSSGVS 2263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2921 DLFYQPFQGAI--QGPEEFAAGVALGVQSMFGHAVGGAAGAVGRITGTVGKGVAALTFDDDYMKKRQEDLNRKP------ 2992
Cdd:COG5043 2264 DLFYEPYQGRFlvDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLVTSDPELQSSRRLVRRRNRpkgsvy 2343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2993 ------QSFGEGMARGLKGLGMgvvggitgvvtKPIEGAKQEGGFGFVKGVGKGLIGVVTRPVSGVVDFASGTMNSVRAV 3066
Cdd:COG5043 2344 gvtagaTSLYDSTSSGEKGLAL-----------EPIIGAATNGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGIKNT 2412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 3067 AG--TNREAGPLRPPRVLREDKIVKPYSSGDAYGFKVFKDTDRGELAETDEFVTYAS------ISEKMVLIITDRRLVLS 3138
Cdd:COG5043 2413 TTvlDYHDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTLDAGKYPLDEYKFHDIInnvaviISRDIHAIVTSKILILK 2492

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 25143253 3139 KRTDMMGV-----------WQTEWGSEYC-KIKEPEFIPN---GVKILLKEKKK 3177
Cdd:COG5043 2493 DYIPSKAVqgpkiyskesnEKLLFNLEQFdSGIDPSFVRSvksNVEGAVPEKIK 2546
SHR-BD super family cl05933
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2224-2490 3.63e-16

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


The actual alignment was detected with superfamily member pfam06650:

Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 81.58  E-value: 3.63e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2224 KVYLYAPFWLVNNTDKMLRhVESSGNMLSNtargcvpcgkKSVVTSQENDDAVQhlptenPIILPFPAIDlSKKKKARVR 2303
Cdd:pfam06650    2 KVSIYSPYVILNKTGLPLI-VRSKGNKNKA----------AGTLESHEGGRRLI------PLMFSFDTFD-DRKNRALLR 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2304 IENlSEWSEEFPLDTVG--NAARITCKGSEHDFDLTVDIKLCQSG--LTKIVTFAPFYLVSNLGKNPMEIREEGQKGWVD 2379
Cdd:pfam06650   64 IGD-SSWSKPFSFDAIGqtNDVVLPSPNGQNEVYLGISVSEGRGKykLTKIVTIAPRFIIKNKLPEDLEIREPGSSKIIS 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2380 IPAETCVGIWPVERKKRKLMCVRYKEEPEAESLLFPITE---NYETLCHMDGEAIGVEVSVSTGESSVAIHLSSfVPGMC 2456
Cdd:pfam06650  143 LPPGELIPLHWLRNVEEKQLCIRFPGSNSQWSSPFNISDvgsTYVKVRRQNSGQKLLKVEIILEDATIFIRIED-EDNNW 221

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 25143253   2457 PVQVMNNLTVPVTFGQKG-------------HIKTTVGPNEFAHFSW 2490
Cdd:pfam06650  222 PFSIRNFSDVEFIFYQRNpnlnsdgenneykPIYYRLPPKSVMPYAW 268
 
Name Accession Description Interval E-value
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 136-373 2.39e-86

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 282.61  E-value: 2.39e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    136 FTEKMITQIIKNLQISVSNIHVRFEDRYTNRHRPFAMGITLEKLNFKTTDENWRETIHKDVVKIIYKLVSLQNLAIYWNS 215
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    216 STEFISDLD--DKEAIRKKLQETIHNGKNGPEGYNYILEPIQMEAKLKLNQKPETDgsnwKIPKIDLAVDMHALSIAIGK 293
Cdd:pfam16908   81 DSESLELLGdlDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE----TIPKIDLDLEFDEIGLTLDD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    294 FQYQDVLLFLEAQERFNAAGQYLKYRPNLNEfKGHYKAWWKFAYTSILEEKVRRRRnNWSWDRMQKHRQLVRKYQKAWVR 373
Cdd:pfam16908  157 RQYRDILSLLDSFHRFLRRQKYRKYRPKVSV-KENPRAWWKYAINAVLEEIRERRR-KWSWDYIKKRRDDRKEYIELYKK 234
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
4-2154 1.66e-74

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 278.69  E-value: 1.66e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    4 ESLVADLLNRFLGDFVDNLDSSQLNIGIWGGDVKLDNLQVKETALDDFDLPIKLKYGYLSSLVLKIPWKNLYNEPVIATV 83
Cdd:COG5043    3 EGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   84 DGLNLIVVPNKGVVYNEEKVAKNIQEIKQKTLARLEEARKERRK----PKDPQADTFTEKMITQIIKNLQISVSNIHVRF 159
Cdd:COG5043   83 EDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWEILRETLEEssssPNISRKQSFIESLITKLIDNIQIYIEDIHLRF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  160 EDRYTN-RHRPFAMGITLEKLNFKTTDENWRETIHKDVVKIIYKLVSLQNLAIYWNSSTEFISDLDDKEAI--RKKLQET 236
Cdd:COG5043  163 EDNLSAdLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEISPCITTEDIDSYLenFQPMIAE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  237 IHNGKNgpegyNYILEPIQMEAKLKLNQKPeTDgsnwKIPKIDLAVDMHALSIAIGKFQYQDVLLFLEAQERFNAAGQYL 316
Cdd:COG5043  243 KSPAYN-----EYILKPVRGTAKVSINKLP-TD----EIPRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  317 KYRPNlNEFKGHYKAWWKFAYTSILEEkVRRRRNNWSWDRMQKHRQLVRKYQKAWVRRQTEASPGADVQ--ATIKEAEKK 394
Cdd:COG5043  313 KYRPK-STPKEKPLEWFKYIILVVLDS-IHEKRYHWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSkeLEKRELTYD 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  395 LDVFNVNVARQQAEleidREGLTRQEDKPTGWVAWGKSWfgggggptPDKKKGAKDIGSqfqEAMTPEEKAKLFEAIDYQ 474
Cdd:COG5043  391 LIKYRSRLFRSLAK----RRNSIYLKPQTHKLQGWFSGL--------WNGKPQAQDEDT---LASTDKTAAELTDQEQKD 455

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  475 ENI---PPTNYPKEFVENKFDFKLGQVAIVVDG------AVSMQLLKLVASVeQRPSASAMHV--ESSIQELRMDGC--- 540
Cdd:COG5043  456 FFSeiePVGQLYSDTVNLDVEVSIAKGSFVIQKhirkinLISQRFENFKSKF-SLNKLDLFDGatNPELKPYRSIRNkpk 534

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  541 -----GTEIIRVRDPSIPWMSFLLdtNPLKGNYDQLVKLAVAPINIKYQAPAINNAIDVFKPP----ESVRlnQLTALAM 611
Cdd:COG5043  535 vreseSLQEIEEESRTHLFASFED--SKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPSrtkiEHVS--EWVYSAA 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  612 SRYEEVKARSATGLAYAVEHRSRLVLDVQIQPARIYVSEGGTySSEKPTLLADMGLLSVVT--VDNSSVDTSGmnKMAAL 689
Cdd:COG5043  611 ATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPEDCT-DPKSPTLFLDAGRISIHSqlVEDAIIKKFR--ELQTL 687

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  690 MEKAYDRFHVKLSNVVIAFAENVEtAENCVFEKESPLHVLKPTGLDIQIHKSSIDDL-KLAKMRVIGDLPNIVIGISDDR 768
Cdd:COG5043  688 ENLMYDRFTISLFNVRCLIGPDYE-GKRELPKGKCDYHILKELKLEINVEISILPKAtNLPKIKVSGHMPHASLMFSDVQ 766

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  769 LIGLMKL-GLSIPTPKADE-----KTKAEKELEVPVAKIKDRAKmrtimeveemeedvtqkeeggdddEKEKKKKTSEQQ 842
Cdd:COG5043  767 YKVIINLmSNILPTISVDEingdyQQFSSASLPPPFFDIKDNFQ------------------------IENHANEQTAAK 822

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  843 VqIELDLRLNQIGVVVY-------RKDAVFCDVSI--LKMACKLQMRTFDMVVTAELGSIKIsMPEFKSLDEKREHLYLI 913
Cdd:COG5043  823 F-HAQQIFAFYFKVDYFicsgldsRSENYLVPVLRarLEFYFDLVARKFNLRVTSNSNDIVD-KEFTYPSSLCDNLLSRS 900

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  914 DNDELQGALMTLKFVQANPESPFFATEYALTEQSVDFRFTKLAVSLHQEGVLELKAFGEALQAQLNELQKNTPE----EK 989
Cdd:COG5043  901 SPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFTSPNDEYMIGEDpeltRK 980

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  990 KVEETARKISRKlsdSVMSIASMSRTPSGKekrQRKKTVGSATQEMDVSRNIKQRIKASFGSLALMigtqkhletslaie 1069
Cdd:COG5043  981 ISDVENIKIEDA---NVRLDNNDIFLYDCI---QLFATVLSYGAFMHMEEREKFFLQLRLMDLELK-------------- 1040

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1070 ninanvkitekamevvatlraISMKDRTPGAVYKKLLSVTGKEdmlrfdfvqyQRTDEQRALMKSSDVDMVVKMRLAQMR 1149
Cdd:COG5043 1041 ---------------------NHEKSNNPDSTIVKIDDNKLFI----------FKYESYDIPDPITDCDCVLDISTGSLH 1089

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1150 FVFLNLWLarlmAWLAPFQN-EAVLAAQAAQAAAAEKAATAAQNVKQIMEQSPPRIQLDVILEApfivvprlSTSRDVIV 1228
Cdd:COG5043 1090 FYFIESYF----NFLSKFKRfKVSFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGE--------RNCRMQLI 1157

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1229 LHLGRLALKNeirgdseyPKAIID---RMDILMTDCSFGMGVMNEDVSAVSSSCLILKPISFKLALQRNLTfaVAKELPE 1305
Cdd:COG5043 1158 IKPGSFYAFS--------KCPVVEknsKLSIFSCELRKGEFSTAVPSSGHHDVLLEELNIHLDLTIDANPT--TGENAYV 1227

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1306 IVVDAHIHSIEAEMSDADYkTLMQTLSGNLAEGADLAippppppsslesSNTAAALTSPGKEKEKKDREANA----GPPV 1381
Cdd:COG5043 1228 FKATGDLDPVILNLCQSQH-LILLDLIDVVTTFFRID------------SSFSTSENLPRELDSEFDRSGTPvklkHSKK 1294

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1382 IEKSHTRIVFQFVLDKISAVLYEGEAVNGERKESDAFAALrLKNVKTSGKIGEDNSIVFAMSLDAFTMDDERKEKT-KIS 1460
Cdd:COG5043 1295 TVVETLDILFTFKLPKIRLNLYTGTFGIHGGDLTGLHNIL-FFEIGLDYGFYSSGTVYAEFSIASFRIEDVNPIKDvVFL 1373

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1461 KLMDKKGSKDDRFLDMSFNQDaEANKQIRLKMSAFFICLCPEFLGCLTRFFNVPQSE---------EQLEKQAVTANVPT 1531
Cdd:COG5043 1374 DVIEYSTNTHNLLVNGCLEYD-SQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAyyshldylvEQEYFNMGNPNQVA 1452

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1532 KAVSASPSASSTFTGGTKTssgppqpvgTLAIDCDMHGVEVILVEDsmhpestQALILSFNVTAASHPNEQTKDTKMNVA 1611
Cdd:COG5043 1453 CGEESYKLYRITIVDTTLV---------FVRDASDMNSYAIPFFFG-------QFLVTQQSIFTVTANNMGIFACKMSET 1516

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1612 VENLTI---FSSYYQSSRRNEVTYQVLTPVRIEALvnmnterkttdaVLKMSALDIKMSPSIIRLLSAVSAEFSKSSAPG 1688
Cdd:COG5043 1517 ANINQLlddFGIRFTISQHCSEKIQIITTLDFDSL------------LLRISVNDFLLLQTILRRIYNFIYALYDKETTD 1584

                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1689 ETGSISQKaaklrkwpnyFDSKPIDHRkywFFAApvaqeaveeeLDVTQEDKSRTDSMIGKESAKVDIERISFTLEAGTG 1768
Cdd:COG5043 1585 EELEKRTK----------DGQLALNPD---FLAA----------SVPTAQPSSVFGIRLCSEEFLINVDGIRLILISDLH 1641

                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1769 AIPVpLIFLDMLVNAEAYDWSSAMRVSSGVSVQMSYYNESVSVWEPIIEPvenekgeferWKLAMTMksrnkqdsSDSSP 1848
Cdd:COG5043 1642 DLPL-LDINIKPFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLEP----------WKVGVHI--------SRNDS 1702

                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1849 QTEVKIEADKMLNVTVTKSLLSLLNKLSEVFATAAkqitPTKTRHLPGISPFVVLNETGISVKVlDTETIRVSENgQAVD 1928
Cdd:COG5043 1703 KTAVHVFSREIADIVLTPRLIATLHFIFTKLISTP----FPIERKCDAPYRIVNYTQTAVSVWA-QFENAADSVE-CVRH 1776

                       2010      2020      2030      2040      2050      2060      2070      2080
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1929 ATHGEFVDVFLKNrKSDVEDRRLSIEQEEITG-DLKFELAGTVRETKIGRAEKRVIHLPRVSDGGHKWLIVAETTVENSR 2007
Cdd:COG5043 1777 LPNNTSTPWKFEE-WRQMQDVVSQDQDRVYIGvHVSNSKYESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNI 1855

                       2090      2100      2110      2120      2130      2140      2150      2160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2008 RLVTLNShvkftnhlsyAVEIYSKRDTTLDLF---GTVEHGETI----PLA---VPLLFSPSGDIYLKPV-DDKYEVSFE 2076
Cdd:COG5043 1856 KHITLRS----------PLLIINETQTEIEVVfcdSDGIQRSQIyhisPEEscsLPIETAYLYSIRIRPVsEDKFNWSSQ 1925

                       2170      2180      2190      2200      2210      2220      2230      2240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2077 SLCWHNFEHNRRQAVRCEAD-STDGSFSGIYIDSVVHEEKIQDGIDDQTTS------IYHVHLHPPLEFHNNL-PFDINI 2148
Cdd:COG5043 1926 AISWKSLVDNQQSIVTCLRQhSRDNTWSTPSCKFVGLHVVANDELYSLVIVnehdlpLMKLDSGADLEVKGVLlLKGVGI 2005


                 ....*.
gi 25143253 2149 ELPEQK 2154
Cdd:COG5043 2006 SLIDRK 2011
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 2803-2982 1.49e-67

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 226.27  E-value: 1.49e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2803 KSFYNDLHISPIMMHLSFSQGGTSGDVAASgvsmpIQSEMINVLLRSVGVTLTELQDVVFKLAYFERKCVFYSPEQLNSE 2882
Cdd:pfam16909    1 KIYFELLHLQPIKLHLSFSRSERVNLEESL-----EKSNPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNR 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2883 IISHYAKQFIKQVYVLVLGLDIIGNPFGLVRDLSAGVEDLFYQPFQGAIQGPEEFAAGVALGVQSMFGHAVGGAAGAVGR 2962
Cdd:pfam16909   76 IQKHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSK 155

                          170       180
                   ....*....|....*....|
gi 25143253   2963 ITGTVGKGVAALTFDDDYMK 2982
Cdd:pfam16909  156 ITGSIGKGLAALTMDKQYQQ 175
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 560-780 3.69e-57

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 198.90  E-value: 3.69e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    560 DTNPLKGNYDQLVKLAVAPINIKYQAPAINNAIDVFKPPESVR--LNQLTALAMSRYEEVKARSATGLAYAVEHRSRLVL 637
Cdd:pfam16910    2 ETNPLDGSADSRLTVKLRPLEIIYDPHFIEEVIDFFKPPESHLelIGALMAAAEATLEGIKEQTRAGLEYALEEHKTLDL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    638 DVQIQPARIYVSEGGTySSEKPTLLADMGLLSVVTvdnSSVDTSGMNKMAA-------------LMEKAYDRFHVKLSNV 704
Cdd:pfam16910   82 DIDLQAPLIIVPEDYT-SKDSPCLILDAGHISVTS---DLVDKSTIKEIKSkqsqqyteedlkeLESLMYDKFSLKLSDT 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25143253    705 VIAFAENVETAENCVFEKE-SPLHVLKPTGLDIQIHKSSI-DDLKLAKMRVIGDLPNIVIGISDDRLIGLMKL-GLSIP 780
Cdd:pfam16910  158 QVLIGPSGEDWKEALTEDDsSPLHILEPINLDLTLEKSILpKAPRLPKFKVSGHLPSLHINFSDDKYKSLMRLiDVSIP 236
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
2684-3177 5.98e-38

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 158.12  E-value: 5.98e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2684 KINHIQIDNQLDACIFPRVLsvVPPPKSVIV-DNTPKPFIELSLLQRQPEFSSIAEIEYGHVLIQEFSVQVDQGLINALL 2762
Cdd:COG5043 2039 ECAWVQIDNQLVLGIYPVIL--YPTEISQEEkEIENHLLPSRKFAVVKDSDSAVTYDKYVTILLQELSIELDEDLALAYL 2116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2763 LLISGEVTRKPYGKeMFDEDIKICHVTLSETASTYrsqrpksFYNDLHISPIMMHLSFSQggtsgDVAASGVSMPIQSEM 2842
Cdd:COG5043 2117 EKLKFPGSKYMDDK-KFDDEIELPDIIINKSGSNI-------YFEFLHLQPTRLHISFSR-----SSESSGEDGKVVPSS 2183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2843 INVLLRSV--GVTLTELQDVVFKLAYFERKCVFYSPEQLNSEIISHYAKQFIKQVYVLVLGLDIIGNPFGLVRDLSAGVE 2920
Cdd:COG5043 2184 NSYSDFYGmlAMTLGNINDAPVRLNSLLMDNARVSLPELFDLIASHYLQQVEYQIYKILGSADFLGNPVGLFETVSSGVS 2263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2921 DLFYQPFQGAI--QGPEEFAAGVALGVQSMFGHAVGGAAGAVGRITGTVGKGVAALTFDDDYMKKRQEDLNRKP------ 2992
Cdd:COG5043 2264 DLFYEPYQGRFlvDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLVTSDPELQSSRRLVRRRNRpkgsvy 2343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2993 ------QSFGEGMARGLKGLGMgvvggitgvvtKPIEGAKQEGGFGFVKGVGKGLIGVVTRPVSGVVDFASGTMNSVRAV 3066
Cdd:COG5043 2344 gvtagaTSLYDSTSSGEKGLAL-----------EPIIGAATNGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGIKNT 2412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 3067 AG--TNREAGPLRPPRVLREDKIVKPYSSGDAYGFKVFKDTDRGELAETDEFVTYAS------ISEKMVLIITDRRLVLS 3138
Cdd:COG5043 2413 TTvlDYHDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTLDAGKYPLDEYKFHDIInnvaviISRDIHAIVTSKILILK 2492

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 25143253 3139 KRTDMMGV-----------WQTEWGSEYC-KIKEPEFIPN---GVKILLKEKKK 3177
Cdd:COG5043 2493 DYIPSKAVqgpkiyskesnEKLLFNLEQFdSGIDPSFVRSvksNVEGAVPEKIK 2546
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2224-2490 3.63e-16

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 81.58  E-value: 3.63e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2224 KVYLYAPFWLVNNTDKMLRhVESSGNMLSNtargcvpcgkKSVVTSQENDDAVQhlptenPIILPFPAIDlSKKKKARVR 2303
Cdd:pfam06650    2 KVSIYSPYVILNKTGLPLI-VRSKGNKNKA----------AGTLESHEGGRRLI------PLMFSFDTFD-DRKNRALLR 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2304 IENlSEWSEEFPLDTVG--NAARITCKGSEHDFDLTVDIKLCQSG--LTKIVTFAPFYLVSNLGKNPMEIREEGQKGWVD 2379
Cdd:pfam06650   64 IGD-SSWSKPFSFDAIGqtNDVVLPSPNGQNEVYLGISVSEGRGKykLTKIVTIAPRFIIKNKLPEDLEIREPGSSKIIS 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2380 IPAETCVGIWPVERKKRKLMCVRYKEEPEAESLLFPITE---NYETLCHMDGEAIGVEVSVSTGESSVAIHLSSfVPGMC 2456
Cdd:pfam06650  143 LPPGELIPLHWLRNVEEKQLCIRFPGSNSQWSSPFNISDvgsTYVKVRRQNSGQKLLKVEIILEDATIFIRIED-EDNNW 221

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 25143253   2457 PVQVMNNLTVPVTFGQKG-------------HIKTTVGPNEFAHFSW 2490
Cdd:pfam06650  222 PFSIRNFSDVEFIFYQRNpnlnsdgenneykPIYYRLPPKSVMPYAW 268
 
Name Accession Description Interval E-value
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 136-373 2.39e-86

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 282.61  E-value: 2.39e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    136 FTEKMITQIIKNLQISVSNIHVRFEDRYTNRHRPFAMGITLEKLNFKTTDENWRETIHKDVVKIIYKLVSLQNLAIYWNS 215
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    216 STEFISDLD--DKEAIRKKLQETIHNGKNGPEGYNYILEPIQMEAKLKLNQKPETDgsnwKIPKIDLAVDMHALSIAIGK 293
Cdd:pfam16908   81 DSESLELLGdlDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE----TIPKIDLDLEFDEIGLTLDD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    294 FQYQDVLLFLEAQERFNAAGQYLKYRPNLNEfKGHYKAWWKFAYTSILEEKVRRRRnNWSWDRMQKHRQLVRKYQKAWVR 373
Cdd:pfam16908  157 RQYRDILSLLDSFHRFLRRQKYRKYRPKVSV-KENPRAWWKYAINAVLEEIRERRR-KWSWDYIKKRRDDRKEYIELYKK 234
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
4-2154 1.66e-74

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 278.69  E-value: 1.66e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    4 ESLVADLLNRFLGDFVDNLDSSQLNIGIWGGDVKLDNLQVKETALDDFDLPIKLKYGYLSSLVLKIPWKNLYNEPVIATV 83
Cdd:COG5043    3 EGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   84 DGLNLIVVPNKGVVYNEEKVAKNIQEIKQKTLARLEEARKERRK----PKDPQADTFTEKMITQIIKNLQISVSNIHVRF 159
Cdd:COG5043   83 EDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWEILRETLEEssssPNISRKQSFIESLITKLIDNIQIYIEDIHLRF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  160 EDRYTN-RHRPFAMGITLEKLNFKTTDENWRETIHKDVVKIIYKLVSLQNLAIYWNSSTEFISDLDDKEAI--RKKLQET 236
Cdd:COG5043  163 EDNLSAdLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEISPCITTEDIDSYLenFQPMIAE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  237 IHNGKNgpegyNYILEPIQMEAKLKLNQKPeTDgsnwKIPKIDLAVDMHALSIAIGKFQYQDVLLFLEAQERFNAAGQYL 316
Cdd:COG5043  243 KSPAYN-----EYILKPVRGTAKVSINKLP-TD----EIPRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  317 KYRPNlNEFKGHYKAWWKFAYTSILEEkVRRRRNNWSWDRMQKHRQLVRKYQKAWVRRQTEASPGADVQ--ATIKEAEKK 394
Cdd:COG5043  313 KYRPK-STPKEKPLEWFKYIILVVLDS-IHEKRYHWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSkeLEKRELTYD 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  395 LDVFNVNVARQQAEleidREGLTRQEDKPTGWVAWGKSWfgggggptPDKKKGAKDIGSqfqEAMTPEEKAKLFEAIDYQ 474
Cdd:COG5043  391 LIKYRSRLFRSLAK----RRNSIYLKPQTHKLQGWFSGL--------WNGKPQAQDEDT---LASTDKTAAELTDQEQKD 455

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  475 ENI---PPTNYPKEFVENKFDFKLGQVAIVVDG------AVSMQLLKLVASVeQRPSASAMHV--ESSIQELRMDGC--- 540
Cdd:COG5043  456 FFSeiePVGQLYSDTVNLDVEVSIAKGSFVIQKhirkinLISQRFENFKSKF-SLNKLDLFDGatNPELKPYRSIRNkpk 534

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  541 -----GTEIIRVRDPSIPWMSFLLdtNPLKGNYDQLVKLAVAPINIKYQAPAINNAIDVFKPP----ESVRlnQLTALAM 611
Cdd:COG5043  535 vreseSLQEIEEESRTHLFASFED--SKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPSrtkiEHVS--EWVYSAA 610

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  612 SRYEEVKARSATGLAYAVEHRSRLVLDVQIQPARIYVSEGGTySSEKPTLLADMGLLSVVT--VDNSSVDTSGmnKMAAL 689
Cdd:COG5043  611 ATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPEDCT-DPKSPTLFLDAGRISIHSqlVEDAIIKKFR--ELQTL 687

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  690 MEKAYDRFHVKLSNVVIAFAENVEtAENCVFEKESPLHVLKPTGLDIQIHKSSIDDL-KLAKMRVIGDLPNIVIGISDDR 768
Cdd:COG5043  688 ENLMYDRFTISLFNVRCLIGPDYE-GKRELPKGKCDYHILKELKLEINVEISILPKAtNLPKIKVSGHMPHASLMFSDVQ 766

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  769 LIGLMKL-GLSIPTPKADE-----KTKAEKELEVPVAKIKDRAKmrtimeveemeedvtqkeeggdddEKEKKKKTSEQQ 842
Cdd:COG5043  767 YKVIINLmSNILPTISVDEingdyQQFSSASLPPPFFDIKDNFQ------------------------IENHANEQTAAK 822

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  843 VqIELDLRLNQIGVVVY-------RKDAVFCDVSI--LKMACKLQMRTFDMVVTAELGSIKIsMPEFKSLDEKREHLYLI 913
Cdd:COG5043  823 F-HAQQIFAFYFKVDYFicsgldsRSENYLVPVLRarLEFYFDLVARKFNLRVTSNSNDIVD-KEFTYPSSLCDNLLSRS 900

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  914 DNDELQGALMTLKFVQANPESPFFATEYALTEQSVDFRFTKLAVSLHQEGVLELKAFGEALQAQLNELQKNTPE----EK 989
Cdd:COG5043  901 SPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFTSPNDEYMIGEDpeltRK 980

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253  990 KVEETARKISRKlsdSVMSIASMSRTPSGKekrQRKKTVGSATQEMDVSRNIKQRIKASFGSLALMigtqkhletslaie 1069
Cdd:COG5043  981 ISDVENIKIEDA---NVRLDNNDIFLYDCI---QLFATVLSYGAFMHMEEREKFFLQLRLMDLELK-------------- 1040

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1070 ninanvkitekamevvatlraISMKDRTPGAVYKKLLSVTGKEdmlrfdfvqyQRTDEQRALMKSSDVDMVVKMRLAQMR 1149
Cdd:COG5043 1041 ---------------------NHEKSNNPDSTIVKIDDNKLFI----------FKYESYDIPDPITDCDCVLDISTGSLH 1089

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1150 FVFLNLWLarlmAWLAPFQN-EAVLAAQAAQAAAAEKAATAAQNVKQIMEQSPPRIQLDVILEApfivvprlSTSRDVIV 1228
Cdd:COG5043 1090 FYFIESYF----NFLSKFKRfKVSFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGE--------RNCRMQLI 1157

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1229 LHLGRLALKNeirgdseyPKAIID---RMDILMTDCSFGMGVMNEDVSAVSSSCLILKPISFKLALQRNLTfaVAKELPE 1305
Cdd:COG5043 1158 IKPGSFYAFS--------KCPVVEknsKLSIFSCELRKGEFSTAVPSSGHHDVLLEELNIHLDLTIDANPT--TGENAYV 1227

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1306 IVVDAHIHSIEAEMSDADYkTLMQTLSGNLAEGADLAippppppsslesSNTAAALTSPGKEKEKKDREANA----GPPV 1381
Cdd:COG5043 1228 FKATGDLDPVILNLCQSQH-LILLDLIDVVTTFFRID------------SSFSTSENLPRELDSEFDRSGTPvklkHSKK 1294

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1382 IEKSHTRIVFQFVLDKISAVLYEGEAVNGERKESDAFAALrLKNVKTSGKIGEDNSIVFAMSLDAFTMDDERKEKT-KIS 1460
Cdd:COG5043 1295 TVVETLDILFTFKLPKIRLNLYTGTFGIHGGDLTGLHNIL-FFEIGLDYGFYSSGTVYAEFSIASFRIEDVNPIKDvVFL 1373

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1461 KLMDKKGSKDDRFLDMSFNQDaEANKQIRLKMSAFFICLCPEFLGCLTRFFNVPQSE---------EQLEKQAVTANVPT 1531
Cdd:COG5043 1374 DVIEYSTNTHNLLVNGCLEYD-SQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAyyshldylvEQEYFNMGNPNQVA 1452

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1532 KAVSASPSASSTFTGGTKTssgppqpvgTLAIDCDMHGVEVILVEDsmhpestQALILSFNVTAASHPNEQTKDTKMNVA 1611
Cdd:COG5043 1453 CGEESYKLYRITIVDTTLV---------FVRDASDMNSYAIPFFFG-------QFLVTQQSIFTVTANNMGIFACKMSET 1516

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1612 VENLTI---FSSYYQSSRRNEVTYQVLTPVRIEALvnmnterkttdaVLKMSALDIKMSPSIIRLLSAVSAEFSKSSAPG 1688
Cdd:COG5043 1517 ANINQLlddFGIRFTISQHCSEKIQIITTLDFDSL------------LLRISVNDFLLLQTILRRIYNFIYALYDKETTD 1584

                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1689 ETGSISQKaaklrkwpnyFDSKPIDHRkywFFAApvaqeaveeeLDVTQEDKSRTDSMIGKESAKVDIERISFTLEAGTG 1768
Cdd:COG5043 1585 EELEKRTK----------DGQLALNPD---FLAA----------SVPTAQPSSVFGIRLCSEEFLINVDGIRLILISDLH 1641

                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1769 AIPVpLIFLDMLVNAEAYDWSSAMRVSSGVSVQMSYYNESVSVWEPIIEPvenekgeferWKLAMTMksrnkqdsSDSSP 1848
Cdd:COG5043 1642 DLPL-LDINIKPFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLEP----------WKVGVHI--------SRNDS 1702

                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1849 QTEVKIEADKMLNVTVTKSLLSLLNKLSEVFATAAkqitPTKTRHLPGISPFVVLNETGISVKVlDTETIRVSENgQAVD 1928
Cdd:COG5043 1703 KTAVHVFSREIADIVLTPRLIATLHFIFTKLISTP----FPIERKCDAPYRIVNYTQTAVSVWA-QFENAADSVE-CVRH 1776

                       2010      2020      2030      2040      2050      2060      2070      2080
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 1929 ATHGEFVDVFLKNrKSDVEDRRLSIEQEEITG-DLKFELAGTVRETKIGRAEKRVIHLPRVSDGGHKWLIVAETTVENSR 2007
Cdd:COG5043 1777 LPNNTSTPWKFEE-WRQMQDVVSQDQDRVYIGvHVSNSKYESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNI 1855

                       2090      2100      2110      2120      2130      2140      2150      2160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2008 RLVTLNShvkftnhlsyAVEIYSKRDTTLDLF---GTVEHGETI----PLA---VPLLFSPSGDIYLKPV-DDKYEVSFE 2076
Cdd:COG5043 1856 KHITLRS----------PLLIINETQTEIEVVfcdSDGIQRSQIyhisPEEscsLPIETAYLYSIRIRPVsEDKFNWSSQ 1925

                       2170      2180      2190      2200      2210      2220      2230      2240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2077 SLCWHNFEHNRRQAVRCEAD-STDGSFSGIYIDSVVHEEKIQDGIDDQTTS------IYHVHLHPPLEFHNNL-PFDINI 2148
Cdd:COG5043 1926 AISWKSLVDNQQSIVTCLRQhSRDNTWSTPSCKFVGLHVVANDELYSLVIVnehdlpLMKLDSGADLEVKGVLlLKGVGI 2005


                 ....*.
gi 25143253 2149 ELPEQK 2154
Cdd:COG5043 2006 SLIDRK 2011
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 2803-2982 1.49e-67

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 226.27  E-value: 1.49e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2803 KSFYNDLHISPIMMHLSFSQGGTSGDVAASgvsmpIQSEMINVLLRSVGVTLTELQDVVFKLAYFERKCVFYSPEQLNSE 2882
Cdd:pfam16909    1 KIYFELLHLQPIKLHLSFSRSERVNLEESL-----EKSNPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNR 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2883 IISHYAKQFIKQVYVLVLGLDIIGNPFGLVRDLSAGVEDLFYQPFQGAIQGPEEFAAGVALGVQSMFGHAVGGAAGAVGR 2962
Cdd:pfam16909   76 IQKHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSK 155

                          170       180
                   ....*....|....*....|
gi 25143253   2963 ITGTVGKGVAALTFDDDYMK 2982
Cdd:pfam16909  156 ITGSIGKGLAALTMDKQYQQ 175
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 560-780 3.69e-57

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 198.90  E-value: 3.69e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    560 DTNPLKGNYDQLVKLAVAPINIKYQAPAINNAIDVFKPPESVR--LNQLTALAMSRYEEVKARSATGLAYAVEHRSRLVL 637
Cdd:pfam16910    2 ETNPLDGSADSRLTVKLRPLEIIYDPHFIEEVIDFFKPPESHLelIGALMAAAEATLEGIKEQTRAGLEYALEEHKTLDL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253    638 DVQIQPARIYVSEGGTySSEKPTLLADMGLLSVVTvdnSSVDTSGMNKMAA-------------LMEKAYDRFHVKLSNV 704
Cdd:pfam16910   82 DIDLQAPLIIVPEDYT-SKDSPCLILDAGHISVTS---DLVDKSTIKEIKSkqsqqyteedlkeLESLMYDKFSLKLSDT 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25143253    705 VIAFAENVETAENCVFEKE-SPLHVLKPTGLDIQIHKSSI-DDLKLAKMRVIGDLPNIVIGISDDRLIGLMKL-GLSIP 780
Cdd:pfam16910  158 QVLIGPSGEDWKEALTEDDsSPLHILEPINLDLTLEKSILpKAPRLPKFKVSGHLPSLHINFSDDKYKSLMRLiDVSIP 236
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 3-117 4.19e-43

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 153.88  E-value: 4.19e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253      3 FESLVADLLNRFLGDFVDNLDSSQLNIGIWGGDVKLDNLQVKETALDDFDLPIKLKYGYLSSLVLKIPWKNLYNEPVIAT 82
Cdd:pfam12624    1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEPVVIE 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 25143253     83 VDGLNLIVVP-NKGVVYNEEKVAKNIQEIKQKTLAR 117
Cdd:pfam12624   81 IEDVYLLAVPkDESEEYDEEEEEKRELAAKKEKLAA 116
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
2684-3177 5.98e-38

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 158.12  E-value: 5.98e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2684 KINHIQIDNQLDACIFPRVLsvVPPPKSVIV-DNTPKPFIELSLLQRQPEFSSIAEIEYGHVLIQEFSVQVDQGLINALL 2762
Cdd:COG5043 2039 ECAWVQIDNQLVLGIYPVIL--YPTEISQEEkEIENHLLPSRKFAVVKDSDSAVTYDKYVTILLQELSIELDEDLALAYL 2116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2763 LLISGEVTRKPYGKeMFDEDIKICHVTLSETASTYrsqrpksFYNDLHISPIMMHLSFSQggtsgDVAASGVSMPIQSEM 2842
Cdd:COG5043 2117 EKLKFPGSKYMDDK-KFDDEIELPDIIINKSGSNI-------YFEFLHLQPTRLHISFSR-----SSESSGEDGKVVPSS 2183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2843 INVLLRSV--GVTLTELQDVVFKLAYFERKCVFYSPEQLNSEIISHYAKQFIKQVYVLVLGLDIIGNPFGLVRDLSAGVE 2920
Cdd:COG5043 2184 NSYSDFYGmlAMTLGNINDAPVRLNSLLMDNARVSLPELFDLIASHYLQQVEYQIYKILGSADFLGNPVGLFETVSSGVS 2263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2921 DLFYQPFQGAI--QGPEEFAAGVALGVQSMFGHAVGGAAGAVGRITGTVGKGVAALTFDDDYMKKRQEDLNRKP------ 2992
Cdd:COG5043 2264 DLFYEPYQGRFlvDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLVTSDPELQSSRRLVRRRNRpkgsvy 2343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 2993 ------QSFGEGMARGLKGLGMgvvggitgvvtKPIEGAKQEGGFGFVKGVGKGLIGVVTRPVSGVVDFASGTMNSVRAV 3066
Cdd:COG5043 2344 gvtagaTSLYDSTSSGEKGLAL-----------EPIIGAATNGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGIKNT 2412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253 3067 AG--TNREAGPLRPPRVLREDKIVKPYSSGDAYGFKVFKDTDRGELAETDEFVTYAS------ISEKMVLIITDRRLVLS 3138
Cdd:COG5043 2413 TTvlDYHDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTLDAGKYPLDEYKFHDIInnvaviISRDIHAIVTSKILILK 2492

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 25143253 3139 KRTDMMGV-----------WQTEWGSEYC-KIKEPEFIPN---GVKILLKEKKK 3177
Cdd:COG5043 2493 DYIPSKAVqgpkiyskesnEKLLFNLEQFdSGIDPSFVRSvksNVEGAVPEKIK 2546
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2224-2490 3.63e-16

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 81.58  E-value: 3.63e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2224 KVYLYAPFWLVNNTDKMLRhVESSGNMLSNtargcvpcgkKSVVTSQENDDAVQhlptenPIILPFPAIDlSKKKKARVR 2303
Cdd:pfam06650    2 KVSIYSPYVILNKTGLPLI-VRSKGNKNKA----------AGTLESHEGGRRLI------PLMFSFDTFD-DRKNRALLR 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2304 IENlSEWSEEFPLDTVG--NAARITCKGSEHDFDLTVDIKLCQSG--LTKIVTFAPFYLVSNLGKNPMEIREEGQKGWVD 2379
Cdd:pfam06650   64 IGD-SSWSKPFSFDAIGqtNDVVLPSPNGQNEVYLGISVSEGRGKykLTKIVTIAPRFIIKNKLPEDLEIREPGSSKIIS 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   2380 IPAETCVGIWPVERKKRKLMCVRYKEEPEAESLLFPITE---NYETLCHMDGEAIGVEVSVSTGESSVAIHLSSfVPGMC 2456
Cdd:pfam06650  143 LPPGELIPLHWLRNVEEKQLCIRFPGSNSQWSSPFNISDvgsTYVKVRRQNSGQKLLKVEIILEDATIFIRIED-EDNNW 221

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 25143253   2457 PVQVMNNLTVPVTFGQKG-------------HIKTTVGPNEFAHFSW 2490
Cdd:pfam06650  222 PFSIRNFSDVEFIFYQRNpnlnsdgenneykPIYYRLPPKSVMPYAW 268
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1203-1329 6.11e-05

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 47.13  E-value: 6.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25143253   1203 RIQLDVILEAPFIVVPRLSTSRD--VIVLHLGRLALK---------NEIR--GDSEYPKAII--------DRMDILMTDC 1261
Cdd:pfam16910   78 TLDLDIDLQAPLIIVPEDYTSKDspCLILDAGHISVTsdlvdkstiKEIKskQSQQYTEEDLkeleslmyDKFSLKLSDT 157

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25143253   1262 SFGMGVMNED-----VSAVSSSCLILKPISFKLALQRNLtfaVAKE--LPEIVVDAHIHSIEAEMSDADYKTLMQ 1329
Cdd:pfam16910  158 QVLIGPSGEDwkealTEDDSSPLHILEPINLDLTLEKSI---LPKAprLPKFKVSGHLPSLHINFSDDKYKSLMR 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH