|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
305-602 |
2.25e-48 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 174.33 E-value: 2.25e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 305 QTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLILVGGteDS 384
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA----TGKLLRTLTGHSG-AVTSVAFSPDGKLLASGS--DD 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 385 HELYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQKGQLYLCDLN-GTIVDSWEG--VRVNSIAFRADNKTIL 461
Cdd:COG2319 184 GTVRLWDLATGKLLRTLTGH-TGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLA 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 462 AADNHYRIRGYNFDSPRSDFDILREPHPIMTFSInSADRLALLNVSNQG-LHLWDIEDKCLVRRFQGIRQSNFAIhsCFG 540
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24668168 541 GvNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVyPSLLASASDDATVRIW 602
Cdd:COG2319 340 P-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
307-602 |
3.28e-34 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 131.69 E-value: 3.28e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 307 IQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDP--YKLTLKhrrvldgQAQLSVSFVSWSPDSKLILVGGTEDS 384
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgeLLRTLK-------GHTGPVRDVAASADGTYLASGSSDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 385 heLYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQKGQLYLCDL-NGTIVDSWEGVR--VNSIAFRADNKTIL 461
Cdd:cd00200 75 --IRLWDLETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTdwVNSVAFSPDGTFVA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 462 AA-DNHYrIRGYNFDSPRSDFDILREPHPIMTFSInSADRLALLNVSNQG-LHLWDIEDKCLVRRFQGirqSNFAIHSCF 539
Cdd:cd00200 152 SSsQDGT-IKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRG---HENGVNSVA 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24668168 540 GGVNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVYPsLLASASDDATVRIW 602
Cdd:cd00200 227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
|
|
| CTLH |
smart00668 |
C-terminal to LisH motif; Alpha-helical motif of unknown function. |
129-190 |
6.69e-09 |
|
C-terminal to LisH motif; Alpha-helical motif of unknown function.
Pssm-ID: 128914 Cd Length: 58 Bit Score: 52.19 E-value: 6.69e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24668168 129 EHPSATKFREHVLMGDWSKADSDLKDLEPLIDNGKlatiTEMKFILLEQKYLEHLDDGNPLD 190
Cdd:smart00668 1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERN----SKLEFELRKQKFLELVRQGKLEE 58
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
538-602 |
6.77e-08 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 55.73 E-value: 6.77e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24668168 538 CFGGVnesfVASGSEDKVVYIWHIKREE--------PLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIW 602
Cdd:PTZ00420 85 CFSEI----LASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
303-342 |
9.83e-08 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 48.46 E-value: 9.83e-08
10 20 30 40
....*....|....*....|....*....|....*....|
gi 24668168 303 PMQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWD 342
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
304-342 |
1.70e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 45.03 E-value: 1.70e-06
10 20 30
....*....|....*....|....*....|....*....
gi 24668168 304 MQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWD 342
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| LisH_TPL |
pfam17814 |
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ... |
98-126 |
2.31e-05 |
|
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.
Pssm-ID: 375350 Cd Length: 30 Bit Score: 41.61 E-value: 2.31e-05
10 20
....*....|....*....|....*....
gi 24668168 98 QEIIRLIGQYLHDVGLDKSVQTLMLESGC 126
Cdd:pfam17814 2 QDVVRLILQFLKENGLHRTLQALQTESGV 30
|
|
| LisH |
smart00667 |
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ... |
96-126 |
9.81e-03 |
|
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913 Cd Length: 34 Bit Score: 33.95 E-value: 9.81e-03
10 20 30
....*....|....*....|....*....|.
gi 24668168 96 SNQEIIRLIGQYLHDVGLDKSVQTLMLESGC 126
Cdd:smart00667 2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
305-602 |
2.25e-48 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 174.33 E-value: 2.25e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 305 QTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLILVGGteDS 384
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA----TGKLLRTLTGHSG-AVTSVAFSPDGKLLASGS--DD 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 385 HELYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQKGQLYLCDLN-GTIVDSWEG--VRVNSIAFRADNKTIL 461
Cdd:COG2319 184 GTVRLWDLATGKLLRTLTGH-TGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLA 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 462 AADNHYRIRGYNFDSPRSDFDILREPHPIMTFSInSADRLALLNVSNQG-LHLWDIEDKCLVRRFQGIRQSNFAIhsCFG 540
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24668168 541 GvNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVyPSLLASASDDATVRIW 602
Cdd:COG2319 340 P-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
305-602 |
2.00e-40 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 152.37 E-value: 2.00e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 305 QTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLILVGGteDS 384
Cdd:COG2319 69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA----TGLLLRTLTGHTG-AVRSVAFSPDGKTLASGS--AD 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 385 HELYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQKGQLYLCDL-NGTIVDSWEG--VRVNSIAFRADNKTIL 461
Cdd:COG2319 142 GTVRLWDLATGKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLaTGKLLRTLTGhtGAVRSVAFSPDGKLLA 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 462 AADNHYRIRGYNFDSPRSDFDILREPHPIMTFSINSADRLALLNVSNQGLHLWDIEDKCLVRRFQGIRQSNFAIhsCFGG 541
Cdd:COG2319 221 SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSP 298
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24668168 542 vNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVyPSLLASASDDATVRIW 602
Cdd:COG2319 299 -DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLW 357
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
305-562 |
1.14e-34 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 135.81 E-value: 1.14e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 305 QTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLILVGGteDS 384
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGHTG-AVRSVAFSPDGKLLASGS--AD 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 385 HELYIWNVDDGKLVVKFsQSLEDSLACGAFSRDGARFVCGGQKGQLYLCDLN-GTIVDSWEG--VRVNSIAFRADNKTIL 461
Cdd:COG2319 226 GTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtGELLRTLTGhsGGVNSVAFSPDGKLLA 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 462 AADNHYRIRGYNFDSPRSDFDILREPHPIMTFSINSADRLALLNVSNQGLHLWDIEDKCLVRRFQGIRQsnfAIHSCFGG 541
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSVAFS 381
|
250 260
....*....|....*....|.
gi 24668168 542 VNESFVASGSEDKVVYIWHIK 562
Cdd:COG2319 382 PDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
307-602 |
3.28e-34 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 131.69 E-value: 3.28e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 307 IQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDP--YKLTLKhrrvldgQAQLSVSFVSWSPDSKLILVGGTEDS 384
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgeLLRTLK-------GHTGPVRDVAASADGTYLASGSSDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 385 heLYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQKGQLYLCDL-NGTIVDSWEGVR--VNSIAFRADNKTIL 461
Cdd:cd00200 75 --IRLWDLETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTdwVNSVAFSPDGTFVA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 462 AA-DNHYrIRGYNFDSPRSDFDILREPHPIMTFSInSADRLALLNVSNQG-LHLWDIEDKCLVRRFQGirqSNFAIHSCF 539
Cdd:cd00200 152 SSsQDGT-IKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRG---HENGVNSVA 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24668168 540 GGVNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVYPsLLASASDDATVRIW 602
Cdd:cd00200 227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
305-476 |
8.52e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 113.08 E-value: 8.52e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 305 QTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLILVGGteDS 384
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA----TGELLRTLTGHSG-GVNSVAFSPDGKLLASGS--DD 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 385 HELYIWNVDDGKLVVKFSQSLEDSLACgAFSRDGARFVCGGQKGQLYLCDLN-GTIVDSWEGV--RVNSIAFRADNKTIL 461
Cdd:COG2319 310 GTVRLWDLATGKLLRTLTGHTGAVRSV-AFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHtgAVTSVAFSPDGRTLA 388
|
170
....*....|....*
gi 24668168 462 AADNHYRIRGYNFDS 476
Cdd:COG2319 389 SGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
322-602 |
5.40e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 95.75 E-value: 5.40e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 322 FSPDGLKLATGSKDSTVIIWDvdpykLTLKHRRVLDGQAQLSVSFVSWSPDSKLILVGGTEDSHELyiWNVDDGKLVVKF 401
Cdd:COG2319 2 LSADGAALAAASADLALALLA-----AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLL--LDAAAGALLATL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 402 SQSLEDSLACgAFSRDGARFVCGGQKGQLYLCDL-NGTIVDSWEGVR--VNSIAFRADNKTILAADNHYRIRGYNFDSPR 478
Cdd:COG2319 75 LGHTAAVLSV-AFSPDGRLLASASADGTVRLWDLaTGLLLRTLTGHTgaVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 479 SDFDILREPHPIMTFSINSADRLALLNVSNQGLHLWDIEDKCLVRRFQGirqSNFAIHS-CFGGvNESFVASGSEDKVVY 557
Cdd:COG2319 154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG---HTGAVRSvAFSP-DGKLLASGSADGTVR 229
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 24668168 558 IWHIKREEPLAKLAGHTKTVNCVSWNPvYPSLLASASDDATVRIW 602
Cdd:COG2319 230 LWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLW 273
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
304-426 |
2.45e-14 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 73.91 E-value: 2.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 304 MQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLiLVGGTED 383
Cdd:cd00200 167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRGHEN-GVNSVAFSPDGYL-LASGSED 240
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 24668168 384 SHeLYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQ 426
Cdd:cd00200 241 GT-IRVWDLRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSA 281
|
|
| CTLH |
smart00668 |
C-terminal to LisH motif; Alpha-helical motif of unknown function. |
129-190 |
6.69e-09 |
|
C-terminal to LisH motif; Alpha-helical motif of unknown function.
Pssm-ID: 128914 Cd Length: 58 Bit Score: 52.19 E-value: 6.69e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24668168 129 EHPSATKFREHVLMGDWSKADSDLKDLEPLIDNGKlatiTEMKFILLEQKYLEHLDDGNPLD 190
Cdd:smart00668 1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERN----SKLEFELRKQKFLELVRQGKLEE 58
|
|
| TolB |
COG0823 |
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ... |
306-438 |
3.90e-08 |
|
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440585 [Multi-domain] Cd Length: 158 Bit Score: 53.14 E-value: 3.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 306 TIQILTDHCDEVWFCKFSPDGLKLA-TGSKDSTVIIWDVDPykLTLKHRRVLDGQAqlSVSFVSWSPDSKLILVGGTEDS 384
Cdd:COG0823 22 EPRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVVDA--DGGEPRRLTFGGG--YNASPSWSPDGKRLAFVSRSDG 97
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 24668168 385 H-ELYIWNVDDGKLVVkfsqsLEDSLACGAFSRDGARFVC---GGQKGQLYLCDLNGT 438
Cdd:COG0823 98 RfDIYVLDLDGGAPRR-----LTDGPGSPSWSPDGRRIVFssdRGGRPDLYVVDLDGR 150
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
538-602 |
6.77e-08 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 55.73 E-value: 6.77e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24668168 538 CFGGVnesfVASGSEDKVVYIWHIKREE--------PLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIW 602
Cdd:PTZ00420 85 CFSEI----LASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
303-342 |
9.83e-08 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 48.46 E-value: 9.83e-08
10 20 30 40
....*....|....*....|....*....|....*....|
gi 24668168 303 PMQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWD 342
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
321-418 |
1.51e-07 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 54.66 E-value: 1.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 321 KFSPDGLKLATGSKDSTVIIWDVDPYKLTLkhrrVLDGQAQLSVSFVSWSPDSKLILVGGTEDSH--ELYIWNVDDGKlV 398
Cdd:COG4946 395 VWSPDGKKIAFTDNRGRLWVVDLASGKVRK----VDTDGYGDGISDLAWSPDSKWLAYSKPGPNQlsQIFLYDVETGK-T 469
|
90 100
....*....|....*....|
gi 24668168 399 VKFSQSLEDSlACGAFSRDG 418
Cdd:COG4946 470 VQLTDGRYDD-GSPAFSPDG 488
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
538-618 |
4.05e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 53.17 E-value: 4.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 538 CFGGVNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIWGPKPNGSSAT--TES 615
Cdd:PLN00181 539 CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTikTKA 618
|
...
gi 24668168 616 DDC 618
Cdd:PLN00181 619 NIC 621
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
565-602 |
6.65e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.15 E-value: 6.65e-07
10 20 30
....*....|....*....|....*....|....*...
gi 24668168 565 EPLAKLAGHTKTVNCVSWNPvYPSLLASASDDATVRIW 602
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
304-342 |
1.70e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 45.03 E-value: 1.70e-06
10 20 30
....*....|....*....|....*....|....*....
gi 24668168 304 MQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWD 342
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
565-602 |
1.85e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 44.64 E-value: 1.85e-06
10 20 30
....*....|....*....|....*....|....*...
gi 24668168 565 EPLAKLAGHTKTVNCVSWNPvYPSLLASASDDATVRIW 602
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
525-602 |
5.21e-06 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 49.56 E-value: 5.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 525 FQGIRQSNFAIHSCFGGVNESFVA------SGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVYPSLLASASDDAT 598
Cdd:PTZ00420 19 FDDLRICSRVIDSCGIACSSGFVAvpweveGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLT 98
|
....
gi 24668168 599 VRIW 602
Cdd:PTZ00420 99 IRVW 102
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
408-602 |
1.72e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 48.16 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 408 SLACG-AFSRDGARFVCGG--QKGQLYLCDlngTIVDSWEGVRVNSIAFRADNKTILAADNHY---RIRGYNFDSPRSDF 481
Cdd:PLN00181 484 NLVCAiGFDRDGEFFATAGvnKKIKIFECE---SIIKDGRDIHYPVVELASRSKLSGICWNSYiksQVASSNFEGVVQVW 560
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 482 DILR-------EPHPIMTFSIN--SADRLALLNVSNQG-LHLWDIEdkclvrrfQGIRQSNFAIHS---CFGGVNES--F 546
Cdd:PLN00181 561 DVARsqlvtemKEHEKRVWSIDysSADPTLLASGSDDGsVKLWSIN--------QGVSIGTIKTKAnicCVQFPSESgrS 632
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 24668168 547 VASGSEDKVVYIWHIKREE-PLAKLAGHTKTVNCVSWnpVYPSLLASASDDATVRIW 602
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLW 687
|
|
| LisH_TPL |
pfam17814 |
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ... |
98-126 |
2.31e-05 |
|
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.
Pssm-ID: 375350 Cd Length: 30 Bit Score: 41.61 E-value: 2.31e-05
10 20
....*....|....*....|....*....
gi 24668168 98 QEIIRLIGQYLHDVGLDKSVQTLMLESGC 126
Cdd:pfam17814 2 QDVVRLILQFLKENGLHRTLQALQTESGV 30
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
252-363 |
1.85e-04 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 43.91 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 252 SVMMSPRRLRTLLQQAVELQSQhC-------------PCHDmaWETNLETVSLltdhcctTDGFPMQTIQiltDHCDEVW 318
Cdd:pfam20426 62 SDVLSPRKIGSPLAENVELGAQ-CfatlqtpsenfliSCGN--WENSFQVISL-------NDGRMVQSIR---QHKDVVS 128
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 24668168 319 FCKFSPDGLKLATGSKDSTVIIWDVdpYKLTLKHRRVLDGQAQLS 363
Cdd:pfam20426 129 CVAVTSDGSILATGSYDTTVMVWEV--LRGRSSEKRSRNTQTEFP 171
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
539-602 |
4.06e-04 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 43.34 E-value: 4.06e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24668168 539 FGGVNESFVASGSEDKVVYIWHIKRE-------EPLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIW 602
Cdd:PTZ00421 83 FNPFDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVW 153
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
322-479 |
5.18e-04 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 42.19 E-value: 5.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 322 FSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlsVSFVSWSPDSKLILVggtEDSHELYIWNVDDGKLVVkF 401
Cdd:COG3386 15 WDPDGRLYWVDIPGGRIHRYDPD----GGAVEVFAEPSGR--PNGLAFDPDGRLLVA---DHGRGLVRFDPADGEVTV-L 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 402 SQSLEDSLAC---GAFSRDGaRFVCG-----GQKGQLYLCDLNGTIVDSWEGVRV-NSIAFRADNKTILAAD-NHYRIRG 471
Cdd:COG3386 85 ADEYGKPLNRpndGVVDPDG-RLYFTdmgeyLPTGALYRVDPDGSLRVLADGLTFpNGIAFSPDGRTLYVADtGAGRIYR 163
|
....*...
gi 24668168 472 YNFDSPRS 479
Cdd:COG3386 164 FDLDADGT 171
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
324-464 |
1.16e-03 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 40.83 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668168 324 PDGLKL-ATGSKDSTVIIWDVDPYKLTlkhRRVLDGQAQLSVSFvswSPDSKLILVGGtEDSHELYIWNVDDGKLVVKFS 402
Cdd:COG3391 77 ADGRRLyVANSGSGRVSVIDLATGKVV---ATIPVGGGPRGLAV---DPDGGRLYVAD-SGNGRVSVIDTATGKVVATIP 149
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24668168 403 qsLEDSLACGAFSRDGAR-FVCGGQKGQLYLC----DL-NGTIVDSWE-GVRVNSIAFRADNKTILAAD 464
Cdd:COG3391 150 --VGAGPHGIAVDPDGKRlYVANSGSNTVSVIvsviDTaTGKVVATIPvGGGPVGVAVSPDGRRLYVAN 216
|
|
| LisH |
smart00667 |
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ... |
96-126 |
9.81e-03 |
|
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913 Cd Length: 34 Bit Score: 33.95 E-value: 9.81e-03
10 20 30
....*....|....*....|....*....|.
gi 24668168 96 SNQEIIRLIGQYLHDVGLDKSVQTLMLESGC 126
Cdd:smart00667 2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
|
|
| |
