NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24668160|ref|NP_730647|]
View 

uncharacterized protein Dmel_CG7611, isoform E [Drosophila melanogaster]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
305-602 2.25e-48

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.33  E-value: 2.25e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 305 QTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLILVGGteDS 384
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA----TGKLLRTLTGHSG-AVTSVAFSPDGKLLASGS--DD 183
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 385 HELYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQKGQLYLCDLN-GTIVDSWEG--VRVNSIAFRADNKTIL 461
Cdd:COG2319 184 GTVRLWDLATGKLLRTLTGH-TGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLA 262
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 462 AADNHYRIRGYNFDSPRSDFDILREPHPIMTFSInSADRLALLNVSNQG-LHLWDIEDKCLVRRFQGIRQSNFAIhsCFG 540
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24668160 541 GvNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVyPSLLASASDDATVRIW 602
Cdd:COG2319 340 P-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
129-190 6.69e-09

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 52.19  E-value: 6.69e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24668160    129 EHPSATKFREHVLMGDWSKADSDLKDLEPLIDNGKlatiTEMKFILLEQKYLEHLDDGNPLD 190
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERN----SKLEFELRKQKFLELVRQGKLEE 58
LisH_TPL super family cl39307
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
98-126 2.31e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


The actual alignment was detected with superfamily member pfam17814:

Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 2.31e-05
                          10        20
                  ....*....|....*....|....*....
gi 24668160    98 QEIIRLIGQYLHDVGLDKSVQTLMLESGC 126
Cdd:pfam17814   2 QDVVRLILQFLKENGLHRTLQALQTESGV 30
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
305-602 2.25e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.33  E-value: 2.25e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 305 QTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLILVGGteDS 384
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA----TGKLLRTLTGHSG-AVTSVAFSPDGKLLASGS--DD 183
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 385 HELYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQKGQLYLCDLN-GTIVDSWEG--VRVNSIAFRADNKTIL 461
Cdd:COG2319 184 GTVRLWDLATGKLLRTLTGH-TGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLA 262
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 462 AADNHYRIRGYNFDSPRSDFDILREPHPIMTFSInSADRLALLNVSNQG-LHLWDIEDKCLVRRFQGIRQSNFAIhsCFG 540
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24668160 541 GvNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVyPSLLASASDDATVRIW 602
Cdd:COG2319 340 P-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
307-602 3.28e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 3.28e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 307 IQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDP--YKLTLKhrrvldgQAQLSVSFVSWSPDSKLILVGGTEDS 384
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgeLLRTLK-------GHTGPVRDVAASADGTYLASGSSDKT 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 385 heLYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQKGQLYLCDL-NGTIVDSWEGVR--VNSIAFRADNKTIL 461
Cdd:cd00200  75 --IRLWDLETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTdwVNSVAFSPDGTFVA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 462 AA-DNHYrIRGYNFDSPRSDFDILREPHPIMTFSInSADRLALLNVSNQG-LHLWDIEDKCLVRRFQGirqSNFAIHSCF 539
Cdd:cd00200 152 SSsQDGT-IKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRG---HENGVNSVA 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24668160 540 GGVNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVYPsLLASASDDATVRIW 602
Cdd:cd00200 227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
129-190 6.69e-09

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 52.19  E-value: 6.69e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24668160    129 EHPSATKFREHVLMGDWSKADSDLKDLEPLIDNGKlatiTEMKFILLEQKYLEHLDDGNPLD 190
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERN----SKLEFELRKQKFLELVRQGKLEE 58
PTZ00420 PTZ00420
coronin; Provisional
538-602 6.77e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 55.73  E-value: 6.77e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24668160  538 CFGGVnesfVASGSEDKVVYIWHIKREE--------PLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIW 602
Cdd:PTZ00420  85 CFSEI----LASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
303-342 9.83e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 9.83e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24668160    303 PMQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWD 342
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
304-342 1.70e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24668160   304 MQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWD 342
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
98-126 2.31e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 2.31e-05
                          10        20
                  ....*....|....*....|....*....
gi 24668160    98 QEIIRLIGQYLHDVGLDKSVQTLMLESGC 126
Cdd:pfam17814   2 QDVVRLILQFLKENGLHRTLQALQTESGV 30
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
96-126 9.81e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 33.95  E-value: 9.81e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 24668160     96 SNQEIIRLIGQYLHDVGLDKSVQTLMLESGC 126
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
305-602 2.25e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.33  E-value: 2.25e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 305 QTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLILVGGteDS 384
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA----TGKLLRTLTGHSG-AVTSVAFSPDGKLLASGS--DD 183
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 385 HELYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQKGQLYLCDLN-GTIVDSWEG--VRVNSIAFRADNKTIL 461
Cdd:COG2319 184 GTVRLWDLATGKLLRTLTGH-TGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLA 262
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 462 AADNHYRIRGYNFDSPRSDFDILREPHPIMTFSInSADRLALLNVSNQG-LHLWDIEDKCLVRRFQGIRQSNFAIhsCFG 540
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24668160 541 GvNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVyPSLLASASDDATVRIW 602
Cdd:COG2319 340 P-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
305-602 2.00e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 2.00e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 305 QTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLILVGGteDS 384
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA----TGLLLRTLTGHTG-AVRSVAFSPDGKTLASGS--AD 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 385 HELYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQKGQLYLCDL-NGTIVDSWEG--VRVNSIAFRADNKTIL 461
Cdd:COG2319 142 GTVRLWDLATGKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLaTGKLLRTLTGhtGAVRSVAFSPDGKLLA 220
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 462 AADNHYRIRGYNFDSPRSDFDILREPHPIMTFSINSADRLALLNVSNQGLHLWDIEDKCLVRRFQGIRQSNFAIhsCFGG 541
Cdd:COG2319 221 SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSP 298
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24668160 542 vNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVyPSLLASASDDATVRIW 602
Cdd:COG2319 299 -DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
305-562 1.14e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 1.14e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 305 QTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLILVGGteDS 384
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGHTG-AVRSVAFSPDGKLLASGS--AD 225
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 385 HELYIWNVDDGKLVVKFsQSLEDSLACGAFSRDGARFVCGGQKGQLYLCDLN-GTIVDSWEG--VRVNSIAFRADNKTIL 461
Cdd:COG2319 226 GTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtGELLRTLTGhsGGVNSVAFSPDGKLLA 304
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 462 AADNHYRIRGYNFDSPRSDFDILREPHPIMTFSINSADRLALLNVSNQGLHLWDIEDKCLVRRFQGIRQsnfAIHSCFGG 541
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSVAFS 381
                       250       260
                ....*....|....*....|.
gi 24668160 542 VNESFVASGSEDKVVYIWHIK 562
Cdd:COG2319 382 PDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
307-602 3.28e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 3.28e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 307 IQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDP--YKLTLKhrrvldgQAQLSVSFVSWSPDSKLILVGGTEDS 384
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgeLLRTLK-------GHTGPVRDVAASADGTYLASGSSDKT 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 385 heLYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQKGQLYLCDL-NGTIVDSWEGVR--VNSIAFRADNKTIL 461
Cdd:cd00200  75 --IRLWDLETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTdwVNSVAFSPDGTFVA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 462 AA-DNHYrIRGYNFDSPRSDFDILREPHPIMTFSInSADRLALLNVSNQG-LHLWDIEDKCLVRRFQGirqSNFAIHSCF 539
Cdd:cd00200 152 SSsQDGT-IKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRG---HENGVNSVA 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24668160 540 GGVNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVYPsLLASASDDATVRIW 602
Cdd:cd00200 227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
305-476 8.52e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 8.52e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 305 QTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLILVGGteDS 384
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA----TGELLRTLTGHSG-GVNSVAFSPDGKLLASGS--DD 309
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 385 HELYIWNVDDGKLVVKFSQSLEDSLACgAFSRDGARFVCGGQKGQLYLCDLN-GTIVDSWEGV--RVNSIAFRADNKTIL 461
Cdd:COG2319 310 GTVRLWDLATGKLLRTLTGHTGAVRSV-AFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHtgAVTSVAFSPDGRTLA 388
                       170
                ....*....|....*
gi 24668160 462 AADNHYRIRGYNFDS 476
Cdd:COG2319 389 SGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
322-602 5.40e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.75  E-value: 5.40e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 322 FSPDGLKLATGSKDSTVIIWDvdpykLTLKHRRVLDGQAQLSVSFVSWSPDSKLILVGGTEDSHELyiWNVDDGKLVVKF 401
Cdd:COG2319   2 LSADGAALAAASADLALALLA-----AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLL--LDAAAGALLATL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 402 SQSLEDSLACgAFSRDGARFVCGGQKGQLYLCDL-NGTIVDSWEGVR--VNSIAFRADNKTILAADNHYRIRGYNFDSPR 478
Cdd:COG2319  75 LGHTAAVLSV-AFSPDGRLLASASADGTVRLWDLaTGLLLRTLTGHTgaVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 479 SDFDILREPHPIMTFSINSADRLALLNVSNQGLHLWDIEDKCLVRRFQGirqSNFAIHS-CFGGvNESFVASGSEDKVVY 557
Cdd:COG2319 154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG---HTGAVRSvAFSP-DGKLLASGSADGTVR 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 24668160 558 IWHIKREEPLAKLAGHTKTVNCVSWNPvYPSLLASASDDATVRIW 602
Cdd:COG2319 230 LWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
304-426 2.45e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 2.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 304 MQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlSVSFVSWSPDSKLiLVGGTED 383
Cdd:cd00200 167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRGHEN-GVNSVAFSPDGYL-LASGSED 240
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 24668160 384 SHeLYIWNVDDGKLVVKFSQSlEDSLACGAFSRDGARFVCGGQ 426
Cdd:cd00200 241 GT-IRVWDLRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSA 281
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
129-190 6.69e-09

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 52.19  E-value: 6.69e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24668160    129 EHPSATKFREHVLMGDWSKADSDLKDLEPLIDNGKlatiTEMKFILLEQKYLEHLDDGNPLD 190
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERN----SKLEFELRKQKFLELVRQGKLEE 58
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
306-438 3.90e-08

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 53.14  E-value: 3.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 306 TIQILTDHCDEVWFCKFSPDGLKLA-TGSKDSTVIIWDVDPykLTLKHRRVLDGQAqlSVSFVSWSPDSKLILVGGTEDS 384
Cdd:COG0823  22 EPRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVVDA--DGGEPRRLTFGGG--YNASPSWSPDGKRLAFVSRSDG 97
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24668160 385 H-ELYIWNVDDGKLVVkfsqsLEDSLACGAFSRDGARFVC---GGQKGQLYLCDLNGT 438
Cdd:COG0823  98 RfDIYVLDLDGGAPRR-----LTDGPGSPSWSPDGRRIVFssdRGGRPDLYVVDLDGR 150
PTZ00420 PTZ00420
coronin; Provisional
538-602 6.77e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 55.73  E-value: 6.77e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24668160  538 CFGGVnesfVASGSEDKVVYIWHIKREE--------PLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIW 602
Cdd:PTZ00420  85 CFSEI----LASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
303-342 9.83e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 9.83e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24668160    303 PMQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWD 342
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
321-418 1.51e-07

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 54.66  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160  321 KFSPDGLKLATGSKDSTVIIWDVDPYKLTLkhrrVLDGQAQLSVSFVSWSPDSKLILVGGTEDSH--ELYIWNVDDGKlV 398
Cdd:COG4946  395 VWSPDGKKIAFTDNRGRLWVVDLASGKVRK----VDTDGYGDGISDLAWSPDSKWLAYSKPGPNQlsQIFLYDVETGK-T 469
                         90       100
                 ....*....|....*....|
gi 24668160  399 VKFSQSLEDSlACGAFSRDG 418
Cdd:COG4946  470 VQLTDGRYDD-GSPAFSPDG 488
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
538-618 4.05e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.17  E-value: 4.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160  538 CFGGVNESFVASGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIWGPKPNGSSAT--TES 615
Cdd:PLN00181 539 CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTikTKA 618

                 ...
gi 24668160  616 DDC 618
Cdd:PLN00181 619 NIC 621
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
565-602 6.65e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 6.65e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24668160    565 EPLAKLAGHTKTVNCVSWNPvYPSLLASASDDATVRIW 602
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
304-342 1.70e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24668160   304 MQTIQILTDHCDEVWFCKFSPDGLKLATGSKDSTVIIWD 342
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
565-602 1.85e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.85e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24668160   565 EPLAKLAGHTKTVNCVSWNPvYPSLLASASDDATVRIW 602
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
525-602 5.21e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.56  E-value: 5.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160  525 FQGIRQSNFAIHSCFGGVNESFVA------SGSEDKVVYIWHIKREEPLAKLAGHTKTVNCVSWNPVYPSLLASASDDAT 598
Cdd:PTZ00420  19 FDDLRICSRVIDSCGIACSSGFVAvpweveGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLT 98

                 ....
gi 24668160  599 VRIW 602
Cdd:PTZ00420  99 IRVW 102
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
408-602 1.72e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160  408 SLACG-AFSRDGARFVCGG--QKGQLYLCDlngTIVDSWEGVRVNSIAFRADNKTILAADNHY---RIRGYNFDSPRSDF 481
Cdd:PLN00181 484 NLVCAiGFDRDGEFFATAGvnKKIKIFECE---SIIKDGRDIHYPVVELASRSKLSGICWNSYiksQVASSNFEGVVQVW 560
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160  482 DILR-------EPHPIMTFSIN--SADRLALLNVSNQG-LHLWDIEdkclvrrfQGIRQSNFAIHS---CFGGVNES--F 546
Cdd:PLN00181 561 DVARsqlvtemKEHEKRVWSIDysSADPTLLASGSDDGsVKLWSIN--------QGVSIGTIKTKAnicCVQFPSESgrS 632
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24668160  547 VASGSEDKVVYIWHIKREE-PLAKLAGHTKTVNCVSWnpVYPSLLASASDDATVRIW 602
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLW 687
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
98-126 2.31e-05

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 41.61  E-value: 2.31e-05
                          10        20
                  ....*....|....*....|....*....
gi 24668160    98 QEIIRLIGQYLHDVGLDKSVQTLMLESGC 126
Cdd:pfam17814   2 QDVVRLILQFLKENGLHRTLQALQTESGV 30
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
252-363 1.85e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 43.91  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160   252 SVMMSPRRLRTLLQQAVELQSQhC-------------PCHDmaWETNLETVSLltdhcctTDGFPMQTIQiltDHCDEVW 318
Cdd:pfam20426  62 SDVLSPRKIGSPLAENVELGAQ-CfatlqtpsenfliSCGN--WENSFQVISL-------NDGRMVQSIR---QHKDVVS 128
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 24668160   319 FCKFSPDGLKLATGSKDSTVIIWDVdpYKLTLKHRRVLDGQAQLS 363
Cdd:pfam20426 129 CVAVTSDGSILATGSYDTTVMVWEV--LRGRSSEKRSRNTQTEFP 171
PTZ00421 PTZ00421
coronin; Provisional
539-602 4.06e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.34  E-value: 4.06e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24668160  539 FGGVNESFVASGSEDKVVYIWHIKRE-------EPLAKLAGHTKTVNCVSWNPVYPSLLASASDDATVRIW 602
Cdd:PTZ00421  83 FNPFDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVW 153
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
322-479 5.18e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.19  E-value: 5.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 322 FSPDGLKLATGSKDSTVIIWDVDpyklTLKHRRVLDGQAQlsVSFVSWSPDSKLILVggtEDSHELYIWNVDDGKLVVkF 401
Cdd:COG3386  15 WDPDGRLYWVDIPGGRIHRYDPD----GGAVEVFAEPSGR--PNGLAFDPDGRLLVA---DHGRGLVRFDPADGEVTV-L 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 402 SQSLEDSLAC---GAFSRDGaRFVCG-----GQKGQLYLCDLNGTIVDSWEGVRV-NSIAFRADNKTILAAD-NHYRIRG 471
Cdd:COG3386  85 ADEYGKPLNRpndGVVDPDG-RLYFTdmgeyLPTGALYRVDPDGSLRVLADGLTFpNGIAFSPDGRTLYVADtGAGRIYR 163

                ....*...
gi 24668160 472 YNFDSPRS 479
Cdd:COG3386 164 FDLDADGT 171
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
324-464 1.16e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.83  E-value: 1.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24668160 324 PDGLKL-ATGSKDSTVIIWDVDPYKLTlkhRRVLDGQAQLSVSFvswSPDSKLILVGGtEDSHELYIWNVDDGKLVVKFS 402
Cdd:COG3391  77 ADGRRLyVANSGSGRVSVIDLATGKVV---ATIPVGGGPRGLAV---DPDGGRLYVAD-SGNGRVSVIDTATGKVVATIP 149
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24668160 403 qsLEDSLACGAFSRDGAR-FVCGGQKGQLYLC----DL-NGTIVDSWE-GVRVNSIAFRADNKTILAAD 464
Cdd:COG3391 150 --VGAGPHGIAVDPDGKRlYVANSGSNTVSVIvsviDTaTGKVVATIPvGGGPVGVAVSPDGRRLYVAN 216
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
96-126 9.81e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 33.95  E-value: 9.81e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 24668160     96 SNQEIIRLIGQYLHDVGLDKSVQTLMLESGC 126
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH