NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24643409|ref|NP_728308|]
View 

nucleoporin 205kD, isoform B [Drosophila melanogaster]

Protein Classification

nuclear pore complex Nup192/Nup205 family protein( domain architecture ID 10571003)

nuclear pore complex Nup192/Nup205 family protein; similar to Homo sapiens Nup205 and Saccharomyces cerevisiae Nup192, which are components (nucleoporins, NUPs) of the nuclear pore complex (NPC) that can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
182-1795 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


:

Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1136.98  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    182 EITGLVTNYAESLVDGSGILGRLLQLLEEMDVDKEcamLTTNRAFGSKKHQNQvlgLYEDIQQALAMALFNWSAQRGLPR 261
Cdd:pfam11894    3 SATTLVTNILDSFKEIHGLLQRLLDLVNKADILGE---IQDNRFLGTIKFRRD---SLFKEHELLAQILFGLVAQRGLPK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    262 HIAIRLMHQLANrknhdaGGNMDDVTLIMLMALLYAY----DTSML-LVTEEPNEHTTRLpifsdrefaecfleelyaQS 336
Cdd:pfam11894   77 DDFLKLIDHAKK------ADKYDFLTLHYLPALLAAFgsleDLSVLqDVRELHSKITKSL------------------DS 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    337 SWQAP--RLNAIIAYSFGLTLASL-RHAPlQLQATAISIINRDEMLIDEALGAQVFVFFHSLLLEKD------------- 400
Cdd:pfam11894  133 EWPLYtdGLKAAIIFVFLAEFIGWcKQEP-EERAKQFDFKEDIEKPMDEALEDGAFEFLLSIAADTSnkdwedplrydfr 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    401 -----------------LVYSTQFFYRRVHLLITDFIDFMNSKVSELRGRADESSHTIISFLNEGlepppnlDSNFELLM 463
Cdd:pfam11894  212 sllqrhiprltpeklllSDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFL 284
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    464 LCVAKMHGDPRvtiRLCNEYWgpgdpngstafknTSRSVSLFKFISLASDLLPQTLFKAYLKMISGLTRTDFSARCAFNM 543
Cdd:pfam11894  285 LIIAYLYEGRP---DLALEFW-------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENARAAFNF 348
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    544 LRVPQMATGGK--YAVSWDHFFTTLGNYYTSMRnDFNTNIGMSGETIYRTRSTPKAITQREAEHLVAVMGIIQAVAEHDE 621
Cdd:pfam11894  349 LKDNNNSGKKRrsSSVSWDHIFDSLNYYIDKLR-QKPENFESDGDRQQRQEAIPIELEPESIIFLSSYLRLISSVAKNSE 427
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    622 VSRIMICDHPNWQTPQVLLGLVACATPLFLKAEILHTLAALA-KSKETARVIWFHLE-----ASQIIPTVPVSRSYAQCS 695
Cdd:pfam11894  428 EARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVPRTSSYKPRG 507
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    696 LLEEMEQIESRSEQYNLTRGILQLLYTLM-----------TTNLPKSLGAGQRTPAYEGYLKSMINSVLLKfYNRAYKVP 764
Cdd:pfam11894  508 SYSELEAFESRLEGYPEVRAFLQLLKALLsppedssslfgKLPFPENLGAGYRKPGIWPYLDFVLDEVFLK-STRDYKDP 586
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    765 SEKWQVGAQCLKLLYYLLATYRPSAMDFLETVDEP--------------PYPGFHVMMQLQLKSEMLQLLLCIVEEVRER 830
Cdd:pfam11894  587 AEKWELQLSCLEFIETCLRSFDPSLILFSNPSGINldslvstsdfatyvKLHPFHAVLNYLFNEKVLKALFSIIDEGVDE 666
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    831 LDNYNrfqGKKLLEECSLYALLILEAALAKQNAFFEA-------------------HSAANC-PILLSGLNRmlldlnpr 890
Cdd:pfam11894  667 LDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDEllpilkksqniyrpknvgnHGLSSFyDALLFNLSL-------- 735
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    891 srkpdhVLNIIKYVTYNSwlPRHALAAIKILASVTQLPNVST----------QILSMYGQGSnEKLEIRQGFVECLEMEV 960
Cdd:pfam11894  736 ------VLNLGLYVGYGH--PELALASLKILEKISSSPKFSAssagrllhrnKLLTIFESVD-ESERIKRGFIEQLEAPI 806
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    961 CVgkhdddlldqlalnnhvpylgfgddldneremsgereystiesqlelqagdgaLESKPASIELQLKEAIIKLFEMNLS 1040
Cdd:pfam11894  807 DE-----------------------------------------------------EEQGAESIGLQIKEAILDFLNSNLS 833
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1041 QQL--PNFVYFLLGVDVLREFMANGRQHLAIEMQSSCVNSVVLLLEKYMDKQRHSDKYCEHTARIVERIYHLFHGLCANR 1118
Cdd:pfam11894  834 ASPkrPTIAHFLLGFDVRNDLSLGPDQSTFIASPRSLLHSLLLLLLSSLDLISEGDYIDYAPARLAELILEILYKLCRNP 913
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1119 RTAETILRYFRLTCsdFLLRHLRSLPFRQHREDH----------------------VLHAMGHLLNCVSIDVKLAAKHGQ 1176
Cdd:pfam11894  914 LTSSITLRYLRENC--FLFRHLLSLPPKIDPNTLwngqsfdgvffisspsagallsFLNQRSLLLQYLSLELHSTSQSGS 991
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1177 MTRFNQMCDILLIGNgmersshglsmelghslisqpsssflamdvlpaggsisavahgagsaslgAPNTGVKSLKPSLLq 1256
Cdd:pfam11894  992 PSKKKRYVDLLLGNN--------------------------------------------------ILDGGEPIGSPTIF- 1020
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1257 etsqglhvtRLLDILVLEA-GTLSQPQLEFFDGHLITQLLRDCEASAEAGANSranLINVRKLYYILTDELY---MVQSI 1332
Cdd:pfam11894 1021 ---------DFLDFLNFEFiNFEPQPQLEFFDIKNLSLDLDKCELDDADSGNK---LYDISKLHELLRLELKqllLVQGE 1088
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1333 IASGQRKAISTEIMLLLNHAVNINRVRTQRCATLAFMAAWGQLVQVLFSnmpDAVLPATQRRQHIIDIVEKVLIKV---- 1408
Cdd:pfam11894 1089 SKAGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVS---DGDLSSTVRSNFILEVLQAILPKIndyv 1165
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1409 -QPIQPIIEISVQVSETVLLLLANLRYCCYQAEDQSPEDlaaedslsngngnaigndsqvnalclgqraigtgsdggsgg 1487
Cdd:pfam11894 1166 eLDIAFAEELASLASVLLFDLYAKLRQCINLDEEQKGNL----------------------------------------- 1204
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1488 grdigsggNSSNLRFILKNLVQWIMISEvKSQKLRINLYSSLLNCLRIAKRLRTDEHleyqetlisrqesartynkeqrr 1567
Cdd:pfam11894 1205 --------SSDRLHQLFKTCIDGILSSG-STQKLRSDLYVILNNYLQIVFKNRSSEE----------------------- 1252
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1568 ddrlRLKAMAAEVIGTFGEKLIDTICHDAVTGHDVCRMLALACLDMISEL--QAVSTLCDFVASRGYLKHILESLDQSST 1645
Cdd:pfam11894 1253 ----SLRKETLQIIKSYGEKLIEVICNDAIGGEGTCRITALLLLDSLVHLdsNKSNFILETLSKNNYLLLLVRSLKRTDE 1328
                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1646 ALCGILQPVPDHLRPLY--VYESRMAFLTRMANSNVGARLLLTEQALGVLSNMKVYDQQPDLKSSELNrnepQTFLPSID 1723
Cdd:pfam11894 1329 ELRECLAPDPESLDPLYetAFESKLALLIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDLGLSLDN----PLSLPDAL 1404
                         1690      1700      1710      1720      1730      1740      1750
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24643409   1724 DRFRSILLPALSLCDAIVNSLGPRNNSAAVQVLNFLFAHIDMVEAML-RSATPYMDLG------HLQQVAVISNLFARA 1795
Cdd:pfam11894 1405 ERYFELLVPVLQLITAILLSLGSSNKSAIEQVRKFLKHHRDLVVGVLkRDALPESGIGyaeleeGLQELAKLFVLLATL 1483
 
Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
182-1795 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1136.98  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    182 EITGLVTNYAESLVDGSGILGRLLQLLEEMDVDKEcamLTTNRAFGSKKHQNQvlgLYEDIQQALAMALFNWSAQRGLPR 261
Cdd:pfam11894    3 SATTLVTNILDSFKEIHGLLQRLLDLVNKADILGE---IQDNRFLGTIKFRRD---SLFKEHELLAQILFGLVAQRGLPK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    262 HIAIRLMHQLANrknhdaGGNMDDVTLIMLMALLYAY----DTSML-LVTEEPNEHTTRLpifsdrefaecfleelyaQS 336
Cdd:pfam11894   77 DDFLKLIDHAKK------ADKYDFLTLHYLPALLAAFgsleDLSVLqDVRELHSKITKSL------------------DS 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    337 SWQAP--RLNAIIAYSFGLTLASL-RHAPlQLQATAISIINRDEMLIDEALGAQVFVFFHSLLLEKD------------- 400
Cdd:pfam11894  133 EWPLYtdGLKAAIIFVFLAEFIGWcKQEP-EERAKQFDFKEDIEKPMDEALEDGAFEFLLSIAADTSnkdwedplrydfr 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    401 -----------------LVYSTQFFYRRVHLLITDFIDFMNSKVSELRGRADESSHTIISFLNEGlepppnlDSNFELLM 463
Cdd:pfam11894  212 sllqrhiprltpeklllSDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFL 284
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    464 LCVAKMHGDPRvtiRLCNEYWgpgdpngstafknTSRSVSLFKFISLASDLLPQTLFKAYLKMISGLTRTDFSARCAFNM 543
Cdd:pfam11894  285 LIIAYLYEGRP---DLALEFW-------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENARAAFNF 348
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    544 LRVPQMATGGK--YAVSWDHFFTTLGNYYTSMRnDFNTNIGMSGETIYRTRSTPKAITQREAEHLVAVMGIIQAVAEHDE 621
Cdd:pfam11894  349 LKDNNNSGKKRrsSSVSWDHIFDSLNYYIDKLR-QKPENFESDGDRQQRQEAIPIELEPESIIFLSSYLRLISSVAKNSE 427
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    622 VSRIMICDHPNWQTPQVLLGLVACATPLFLKAEILHTLAALA-KSKETARVIWFHLE-----ASQIIPTVPVSRSYAQCS 695
Cdd:pfam11894  428 EARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVPRTSSYKPRG 507
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    696 LLEEMEQIESRSEQYNLTRGILQLLYTLM-----------TTNLPKSLGAGQRTPAYEGYLKSMINSVLLKfYNRAYKVP 764
Cdd:pfam11894  508 SYSELEAFESRLEGYPEVRAFLQLLKALLsppedssslfgKLPFPENLGAGYRKPGIWPYLDFVLDEVFLK-STRDYKDP 586
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    765 SEKWQVGAQCLKLLYYLLATYRPSAMDFLETVDEP--------------PYPGFHVMMQLQLKSEMLQLLLCIVEEVRER 830
Cdd:pfam11894  587 AEKWELQLSCLEFIETCLRSFDPSLILFSNPSGINldslvstsdfatyvKLHPFHAVLNYLFNEKVLKALFSIIDEGVDE 666
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    831 LDNYNrfqGKKLLEECSLYALLILEAALAKQNAFFEA-------------------HSAANC-PILLSGLNRmlldlnpr 890
Cdd:pfam11894  667 LDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDEllpilkksqniyrpknvgnHGLSSFyDALLFNLSL-------- 735
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    891 srkpdhVLNIIKYVTYNSwlPRHALAAIKILASVTQLPNVST----------QILSMYGQGSnEKLEIRQGFVECLEMEV 960
Cdd:pfam11894  736 ------VLNLGLYVGYGH--PELALASLKILEKISSSPKFSAssagrllhrnKLLTIFESVD-ESERIKRGFIEQLEAPI 806
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    961 CVgkhdddlldqlalnnhvpylgfgddldneremsgereystiesqlelqagdgaLESKPASIELQLKEAIIKLFEMNLS 1040
Cdd:pfam11894  807 DE-----------------------------------------------------EEQGAESIGLQIKEAILDFLNSNLS 833
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1041 QQL--PNFVYFLLGVDVLREFMANGRQHLAIEMQSSCVNSVVLLLEKYMDKQRHSDKYCEHTARIVERIYHLFHGLCANR 1118
Cdd:pfam11894  834 ASPkrPTIAHFLLGFDVRNDLSLGPDQSTFIASPRSLLHSLLLLLLSSLDLISEGDYIDYAPARLAELILEILYKLCRNP 913
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1119 RTAETILRYFRLTCsdFLLRHLRSLPFRQHREDH----------------------VLHAMGHLLNCVSIDVKLAAKHGQ 1176
Cdd:pfam11894  914 LTSSITLRYLRENC--FLFRHLLSLPPKIDPNTLwngqsfdgvffisspsagallsFLNQRSLLLQYLSLELHSTSQSGS 991
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1177 MTRFNQMCDILLIGNgmersshglsmelghslisqpsssflamdvlpaggsisavahgagsaslgAPNTGVKSLKPSLLq 1256
Cdd:pfam11894  992 PSKKKRYVDLLLGNN--------------------------------------------------ILDGGEPIGSPTIF- 1020
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1257 etsqglhvtRLLDILVLEA-GTLSQPQLEFFDGHLITQLLRDCEASAEAGANSranLINVRKLYYILTDELY---MVQSI 1332
Cdd:pfam11894 1021 ---------DFLDFLNFEFiNFEPQPQLEFFDIKNLSLDLDKCELDDADSGNK---LYDISKLHELLRLELKqllLVQGE 1088
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1333 IASGQRKAISTEIMLLLNHAVNINRVRTQRCATLAFMAAWGQLVQVLFSnmpDAVLPATQRRQHIIDIVEKVLIKV---- 1408
Cdd:pfam11894 1089 SKAGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVS---DGDLSSTVRSNFILEVLQAILPKIndyv 1165
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1409 -QPIQPIIEISVQVSETVLLLLANLRYCCYQAEDQSPEDlaaedslsngngnaigndsqvnalclgqraigtgsdggsgg 1487
Cdd:pfam11894 1166 eLDIAFAEELASLASVLLFDLYAKLRQCINLDEEQKGNL----------------------------------------- 1204
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1488 grdigsggNSSNLRFILKNLVQWIMISEvKSQKLRINLYSSLLNCLRIAKRLRTDEHleyqetlisrqesartynkeqrr 1567
Cdd:pfam11894 1205 --------SSDRLHQLFKTCIDGILSSG-STQKLRSDLYVILNNYLQIVFKNRSSEE----------------------- 1252
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1568 ddrlRLKAMAAEVIGTFGEKLIDTICHDAVTGHDVCRMLALACLDMISEL--QAVSTLCDFVASRGYLKHILESLDQSST 1645
Cdd:pfam11894 1253 ----SLRKETLQIIKSYGEKLIEVICNDAIGGEGTCRITALLLLDSLVHLdsNKSNFILETLSKNNYLLLLVRSLKRTDE 1328
                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1646 ALCGILQPVPDHLRPLY--VYESRMAFLTRMANSNVGARLLLTEQALGVLSNMKVYDQQPDLKSSELNrnepQTFLPSID 1723
Cdd:pfam11894 1329 ELRECLAPDPESLDPLYetAFESKLALLIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDLGLSLDN----PLSLPDAL 1404
                         1690      1700      1710      1720      1730      1740      1750
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24643409   1724 DRFRSILLPALSLCDAIVNSLGPRNNSAAVQVLNFLFAHIDMVEAML-RSATPYMDLG------HLQQVAVISNLFARA 1795
Cdd:pfam11894 1405 ERYFELLVPVLQLITAILLSLGSSNKSAIEQVRKFLKHHRDLVVGVLkRDALPESGIGyaeleeGLQELAKLFVLLATL 1483
 
Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
182-1795 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1136.98  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    182 EITGLVTNYAESLVDGSGILGRLLQLLEEMDVDKEcamLTTNRAFGSKKHQNQvlgLYEDIQQALAMALFNWSAQRGLPR 261
Cdd:pfam11894    3 SATTLVTNILDSFKEIHGLLQRLLDLVNKADILGE---IQDNRFLGTIKFRRD---SLFKEHELLAQILFGLVAQRGLPK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    262 HIAIRLMHQLANrknhdaGGNMDDVTLIMLMALLYAY----DTSML-LVTEEPNEHTTRLpifsdrefaecfleelyaQS 336
Cdd:pfam11894   77 DDFLKLIDHAKK------ADKYDFLTLHYLPALLAAFgsleDLSVLqDVRELHSKITKSL------------------DS 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    337 SWQAP--RLNAIIAYSFGLTLASL-RHAPlQLQATAISIINRDEMLIDEALGAQVFVFFHSLLLEKD------------- 400
Cdd:pfam11894  133 EWPLYtdGLKAAIIFVFLAEFIGWcKQEP-EERAKQFDFKEDIEKPMDEALEDGAFEFLLSIAADTSnkdwedplrydfr 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    401 -----------------LVYSTQFFYRRVHLLITDFIDFMNSKVSELRGRADESSHTIISFLNEGlepppnlDSNFELLM 463
Cdd:pfam11894  212 sllqrhiprltpeklllSDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFL 284
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    464 LCVAKMHGDPRvtiRLCNEYWgpgdpngstafknTSRSVSLFKFISLASDLLPQTLFKAYLKMISGLTRTDFSARCAFNM 543
Cdd:pfam11894  285 LIIAYLYEGRP---DLALEFW-------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENARAAFNF 348
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    544 LRVPQMATGGK--YAVSWDHFFTTLGNYYTSMRnDFNTNIGMSGETIYRTRSTPKAITQREAEHLVAVMGIIQAVAEHDE 621
Cdd:pfam11894  349 LKDNNNSGKKRrsSSVSWDHIFDSLNYYIDKLR-QKPENFESDGDRQQRQEAIPIELEPESIIFLSSYLRLISSVAKNSE 427
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    622 VSRIMICDHPNWQTPQVLLGLVACATPLFLKAEILHTLAALA-KSKETARVIWFHLE-----ASQIIPTVPVSRSYAQCS 695
Cdd:pfam11894  428 EARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVPRTSSYKPRG 507
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    696 LLEEMEQIESRSEQYNLTRGILQLLYTLM-----------TTNLPKSLGAGQRTPAYEGYLKSMINSVLLKfYNRAYKVP 764
Cdd:pfam11894  508 SYSELEAFESRLEGYPEVRAFLQLLKALLsppedssslfgKLPFPENLGAGYRKPGIWPYLDFVLDEVFLK-STRDYKDP 586
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    765 SEKWQVGAQCLKLLYYLLATYRPSAMDFLETVDEP--------------PYPGFHVMMQLQLKSEMLQLLLCIVEEVRER 830
Cdd:pfam11894  587 AEKWELQLSCLEFIETCLRSFDPSLILFSNPSGINldslvstsdfatyvKLHPFHAVLNYLFNEKVLKALFSIIDEGVDE 666
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    831 LDNYNrfqGKKLLEECSLYALLILEAALAKQNAFFEA-------------------HSAANC-PILLSGLNRmlldlnpr 890
Cdd:pfam11894  667 LDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDEllpilkksqniyrpknvgnHGLSSFyDALLFNLSL-------- 735
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    891 srkpdhVLNIIKYVTYNSwlPRHALAAIKILASVTQLPNVST----------QILSMYGQGSnEKLEIRQGFVECLEMEV 960
Cdd:pfam11894  736 ------VLNLGLYVGYGH--PELALASLKILEKISSSPKFSAssagrllhrnKLLTIFESVD-ESERIKRGFIEQLEAPI 806
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409    961 CVgkhdddlldqlalnnhvpylgfgddldneremsgereystiesqlelqagdgaLESKPASIELQLKEAIIKLFEMNLS 1040
Cdd:pfam11894  807 DE-----------------------------------------------------EEQGAESIGLQIKEAILDFLNSNLS 833
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1041 QQL--PNFVYFLLGVDVLREFMANGRQHLAIEMQSSCVNSVVLLLEKYMDKQRHSDKYCEHTARIVERIYHLFHGLCANR 1118
Cdd:pfam11894  834 ASPkrPTIAHFLLGFDVRNDLSLGPDQSTFIASPRSLLHSLLLLLLSSLDLISEGDYIDYAPARLAELILEILYKLCRNP 913
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1119 RTAETILRYFRLTCsdFLLRHLRSLPFRQHREDH----------------------VLHAMGHLLNCVSIDVKLAAKHGQ 1176
Cdd:pfam11894  914 LTSSITLRYLRENC--FLFRHLLSLPPKIDPNTLwngqsfdgvffisspsagallsFLNQRSLLLQYLSLELHSTSQSGS 991
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1177 MTRFNQMCDILLIGNgmersshglsmelghslisqpsssflamdvlpaggsisavahgagsaslgAPNTGVKSLKPSLLq 1256
Cdd:pfam11894  992 PSKKKRYVDLLLGNN--------------------------------------------------ILDGGEPIGSPTIF- 1020
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1257 etsqglhvtRLLDILVLEA-GTLSQPQLEFFDGHLITQLLRDCEASAEAGANSranLINVRKLYYILTDELY---MVQSI 1332
Cdd:pfam11894 1021 ---------DFLDFLNFEFiNFEPQPQLEFFDIKNLSLDLDKCELDDADSGNK---LYDISKLHELLRLELKqllLVQGE 1088
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1333 IASGQRKAISTEIMLLLNHAVNINRVRTQRCATLAFMAAWGQLVQVLFSnmpDAVLPATQRRQHIIDIVEKVLIKV---- 1408
Cdd:pfam11894 1089 SKAGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVS---DGDLSSTVRSNFILEVLQAILPKIndyv 1165
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1409 -QPIQPIIEISVQVSETVLLLLANLRYCCYQAEDQSPEDlaaedslsngngnaigndsqvnalclgqraigtgsdggsgg 1487
Cdd:pfam11894 1166 eLDIAFAEELASLASVLLFDLYAKLRQCINLDEEQKGNL----------------------------------------- 1204
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1488 grdigsggNSSNLRFILKNLVQWIMISEvKSQKLRINLYSSLLNCLRIAKRLRTDEHleyqetlisrqesartynkeqrr 1567
Cdd:pfam11894 1205 --------SSDRLHQLFKTCIDGILSSG-STQKLRSDLYVILNNYLQIVFKNRSSEE----------------------- 1252
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1568 ddrlRLKAMAAEVIGTFGEKLIDTICHDAVTGHDVCRMLALACLDMISEL--QAVSTLCDFVASRGYLKHILESLDQSST 1645
Cdd:pfam11894 1253 ----SLRKETLQIIKSYGEKLIEVICNDAIGGEGTCRITALLLLDSLVHLdsNKSNFILETLSKNNYLLLLVRSLKRTDE 1328
                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643409   1646 ALCGILQPVPDHLRPLY--VYESRMAFLTRMANSNVGARLLLTEQALGVLSNMKVYDQQPDLKSSELNrnepQTFLPSID 1723
Cdd:pfam11894 1329 ELRECLAPDPESLDPLYetAFESKLALLIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDLGLSLDN----PLSLPDAL 1404
                         1690      1700      1710      1720      1730      1740      1750
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24643409   1724 DRFRSILLPALSLCDAIVNSLGPRNNSAAVQVLNFLFAHIDMVEAML-RSATPYMDLG------HLQQVAVISNLFARA 1795
Cdd:pfam11894 1405 ERYFELLVPVLQLITAILLSLGSSNKSAIEQVRKFLKHHRDLVVGVLkRDALPESGIGyaeleeGLQELAKLFVLLATL 1483
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure