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Conserved domains on  [gi|24657947|ref|NP_726188|]
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windpipe, isoform C [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-169 1.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  72 HSIDLSHLNLTRLSHLLDKLPELTSADLSHNQLKDLG-HLG--KGLKRLNLKHNQLT--SDKLRKLPQhLQVLNLQHNNI 146
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPeELGnlTNLKELDLSNNQITdlPEPLGNLTN-LEELDLSGNQL 217

                        90       100
                ....*....|....*....|...
gi 24657947 147 THLPLELTHMHQLHQLELSHNAI 169
Cdd:COG4886 218 TDLPEPLANLTNLETLDLSNNQL 240
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-169 1.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  72 HSIDLSHLNLTRLSHLLDKLPELTSADLSHNQLKDLG-HLG--KGLKRLNLKHNQLT--SDKLRKLPQhLQVLNLQHNNI 146
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPeELGnlTNLKELDLSNNQITdlPEPLGNLTN-LEELDLSGNQL 217

                        90       100
                ....*....|....*....|...
gi 24657947 147 THLPLELTHMHQLHQLELSHNAI 169
Cdd:COG4886 218 TDLPEPLANLTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
113-169 4.46e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 4.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657947   113 GLKRLNLKHNQLTS---DKLRKLPqHLQVLNLQHNNITHLPLE-LTHMHQLHQLELSHNAI 169
Cdd:pfam13855   2 NLRSLDLSNNRLTSlddGAFKGLS-NLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-170 1.33e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947   52 CNSTRGLRLTEKTFQSTVP--------VHSIDLSHLNLT-RLSHLLDKLPELTSADLSHNQLkdLGHL-----GKGLKRL 117
Cdd:PLN00113 403 CRSLRRVRLQDNSFSGELPseftklplVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKF--FGGLpdsfgSKRLENL 480

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24657947  118 NLKHNQLTS---DKLRKLPQHLQvLNLQHNNIT-HLPLELTHMHQLHQLELSHNAIN 170
Cdd:PLN00113 481 DLSRNQFSGavpRKLGSLSELMQ-LKLSENKLSgEIPDELSSCKKLVSLDLSHNQLS 536
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-170 1.85e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  80 NLTRLSHL------------LDKLPELTSADLSHNQLKDLGHLGK--GLKRLNLKHNQLTSD-KLRKLPQ-------HLQ 137
Cdd:cd21340  44 FLTNLTHLylqnnqiekienLENLVNLKKLYLGGNRISVVEGLENltNLEELHIENQRLPPGeKLTFDPRslaalsnSLR 123

                        90       100       110
                ....*....|....*....|....*....|...
gi 24657947 138 VLNLQHNNITHLpLELTHMHQLHQLELSHNAIN 170
Cdd:cd21340 124 VLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-169 1.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  72 HSIDLSHLNLTRLSHLLDKLPELTSADLSHNQLKDLG-HLG--KGLKRLNLKHNQLT--SDKLRKLPQhLQVLNLQHNNI 146
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPeELGnlTNLKELDLSNNQITdlPEPLGNLTN-LEELDLSGNQL 217

                        90       100
                ....*....|....*....|...
gi 24657947 147 THLPLELTHMHQLHQLELSHNAI 169
Cdd:COG4886 218 TDLPEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-170 2.05e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 2.05e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  73 SIDLSHLNLTRLSHLLDKLPELTSADLSHNQLKD----LGHLgKGLKRLNLKHNQLTS--DKLRKLPQhLQVLNLQHNNI 146
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDlpepLGNL-TNLKSLDLSNNQLTDlpEELGNLTN-LKELDLSNNQI 194

                        90       100
                ....*....|....*....|....
gi 24657947 147 THLPLELTHMHQLHQLELSHNAIN 170
Cdd:COG4886 195 TDLPEPLGNLTNLEELDLSGNQLT 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-169 4.46e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 4.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  88 LDKLPELTSADLSHNqlKDLGHLgKGLKRLNLKHNQLTS--DKLRKLPqHLQVLNLQHNNITHLPLELTHMHQLHQLELS 165
Cdd:COG4886  92 LGDLTNLTELDLSGN--EELSNL-TNLESLDLSGNQLTDlpEELANLT-NLKELDLSNNQLTDLPEPLGNLTNLKSLDLS 167


                ....
gi 24657947 166 HNAI 169
Cdd:COG4886 168 NNQL 171
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-152 8.06e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 8.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  73 SIDLSHLNLTRLSHLLDKLPELTSADLSHNQLKDLGHLG--KGLKRLNLKHNQLTS-DKLRKLPQhLQVLNLQHNNITHL 149
Cdd:COG4886 209 ELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGnlTNLEELDLSNNQLTDlPPLANLTN-LKTLDLSNNQLTDL 287


                ...
gi 24657947 150 PLE 152
Cdd:COG4886 288 KLK 290
LRR_8 pfam13855
Leucine rich repeat;
113-169 4.46e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 4.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657947   113 GLKRLNLKHNQLTS---DKLRKLPqHLQVLNLQHNNITHLPLE-LTHMHQLHQLELSHNAI 169
Cdd:pfam13855   2 NLRSLDLSNNRLTSlddGAFKGLS-NLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-170 1.33e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947   52 CNSTRGLRLTEKTFQSTVP--------VHSIDLSHLNLT-RLSHLLDKLPELTSADLSHNQLkdLGHL-----GKGLKRL 117
Cdd:PLN00113 403 CRSLRRVRLQDNSFSGELPseftklplVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKF--FGGLpdsfgSKRLENL 480

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24657947  118 NLKHNQLTS---DKLRKLPQHLQvLNLQHNNIT-HLPLELTHMHQLHQLELSHNAIN 170
Cdd:PLN00113 481 DLSRNQFSGavpRKLGSLSELMQ-LKLSENKLSgEIPDELSSCKKLVSLDLSHNQLS 536
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-170 1.85e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  80 NLTRLSHL------------LDKLPELTSADLSHNQLKDLGHLGK--GLKRLNLKHNQLTSD-KLRKLPQ-------HLQ 137
Cdd:cd21340  44 FLTNLTHLylqnnqiekienLENLVNLKKLYLGGNRISVVEGLENltNLEELHIENQRLPPGeKLTFDPRslaalsnSLR 123

                        90       100       110
                ....*....|....*....|....*....|...
gi 24657947 138 VLNLQHNNITHLpLELTHMHQLHQLELSHNAIN 170
Cdd:cd21340 124 VLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
76-176 1.97e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947   76 LSHLNLTRLSHlldKLPE-LTSADLSHNQLKDL-GHLGKGLKRLNLKHNQLTSDKlRKLPQHLQVLNLQHNNITHLPLEL 153
Cdd:PRK15370 185 LKILGLTTIPA---CIPEqITTLILDNNELKSLpENLQGNIKTLYANSNQLTSIP-ATLPDTIQEMELSINRITELPERL 260

                         90       100
                 ....*....|....*....|...
gi 24657947  154 THmhQLHQLELSHNAINCSCQTL 176
Cdd:PRK15370 261 PS--ALQSLDLFHNKISCLPENL 281
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 41-169 3.31e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 53.26  E-value: 3.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  41 QHTHKPLYHLKCNST--RGLRLTEKTFQSTVPVHSIDLSHLNLT-----RLSHLLDKLPELTSADLSHNQLKDLG--HLG 111
Cdd:COG5238 178 QNNSVETVYLGCNQIgdEGIEELAEALTQNTTVTTLWLKRNPIGdegaeILAEALKGNKSLTTLDLSNNQIGDEGviALA 257

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24657947 112 KGLK------RLNLKHNQLTSDKLRKLPQHLQV------LNLQHNNITH-----LPLELTHMHQLHQLELSHNAI 169
Cdd:COG5238 258 EALKnnttveTLYLSGNQIGAEGAIALAKALQGnttltsLDLSVNRIGDegaiaLAEGLQGNKTLHTLNLAYNGI 332
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-182 4.00e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 4.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  72 HSIDLSHLNLTRLSHLLdKLPELTSADLSHNQLKDLGHLG--KGLKRLNLKHNQLTSDKLRKLPQH-----LQVLNLQHN 144
Cdd:COG4886 231 ETLDLSNNQLTDLPELG-NLTNLEELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKELELLlglnsLLLLLLLLN 309

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 24657947 145 NITHLPLELTHMHQLHQLELSHNAINCSCQTLEVRNWL 182
Cdd:COG4886 310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-169 5.39e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 5.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  74 IDLSHLNLTRLSHLLDKLPELTSADLSHNQLKDLghlgKGLKRLNLKHNQLTSDklrklPQHLQVLNLQHNNITHLPLEL 153
Cdd:COG4886  62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL----TNLTELDLSGNEELSN-----LTNLESLDLSGNQLTDLPEEL 132

                        90
                ....*....|....*.
gi 24657947 154 THMHQLHQLELSHNAI 169
Cdd:COG4886 133 ANLTNLKELDLSNNQL 148
LRR_8 pfam13855
Leucine rich repeat;
92-146 1.30e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.30e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24657947    92 PELTSADLSHNQLKDLG-----HLgKGLKRLNLKHNQLTS---DKLRKLPQhLQVLNLQHNNI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgafkGL-SNLKVLDLSNNLLTTlspGAFSGLPS-LRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-169 1.83e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 1.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  76 LSHL-NLTRLsHL----------LDKLPELTSADLSHNQLKD----------LGHLGKGLKRLNLKHNQLTSDK-LRKLp 133
Cdd:cd21340  64 LENLvNLKKL-YLggnrisvvegLENLTNLEELHIENQRLPPgekltfdprsLAALSNSLRVLNISGNNIDSLEpLAPL- 141

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 24657947 134 QHLQVLNLQHNNITHL-PLE--LTHMHQLHQLELSHNAI 169
Cdd:cd21340 142 RNLEQLDASNNQISDLeELLdlLSSWPSLRELDLTGNPV 180
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 71-169 5.64e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 5.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  71 VHSIDLSHLNLT-----RLSHLLDKLPELTSADLSHNQLKDLG--HLGKGLKR------LNLKHNQLTSDKLRKLPQHLQ 137
Cdd:COG5238 266 VETLYLSGNQIGaegaiALAKALQGNTTLTSLDLSVNRIGDEGaiALAEGLQGnktlhtLNLAYNGIGAQGAIALAKALQ 345

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 24657947 138 V------LNLQHNNIT--------HLPLELThmhQLHQLELSHNAI 169
Cdd:COG5238 346 EnttlhsLDLSDNQIGdegaialaKYLEGNT---TLRELNLGKNNI 388
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 31-176 9.69e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 9.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  31 CPADCTCSLSQHTHKPLYHLKCN----STRGLRLTEKTFQSTVP-VHSIDLSHLNLT-----RLSHLLDKLPELTSADLS 100
Cdd:cd00116  94 GPDGCGVLESLLRSSSLQELKLNnnglGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEgasceALAKALRANRDLKELNLA 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947 101 HNQLKDLG--HLGKG------LKRLNLKHNQLTSDKLRKL------PQHLQVLNLQHNNITHLPLE------LTHMHQLH 160
Cdd:cd00116 174 NNGIGDAGirALAEGlkancnLEVLDLNNNGLTDEGASALaetlasLKSLEVLNLGDNNLTDAGAAalasalLSPNISLL 253

                       170
                ....*....|....*..
gi 24657947 161 QLELSHNAINCS-CQTL 176
Cdd:cd00116 254 TLSLSCNDITDDgAKDL 270
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 63-156 3.22e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 3.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  63 KTFQSTVPVHSIDLSHLNLT-----RLSHLLDKLPELTSADLSHNQLKDLGHLG--------KGLKRLNLKHNQLTSDKL 129
Cdd:COG5238 314 EGLQGNKTLHTLNLAYNGIGaqgaiALAKALQENTTLHSLDLSDNQIGDEGAIAlakylegnTTLRELNLGKNNIGKQGA 393

                        90       100
                ....*....|....*....|....*..
gi 24657947 130 RKLPQHlqvlnLQHNNITHLPLELTHM 156
Cdd:COG5238 394 EALIDA-----LQTNRLHTLILDGNLI 415
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-169 3.84e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 3.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947   71 VHSIDLSHLNLT-RLSHLLDKLPELTSADLSHNQLK-----DLGHLGKGLKRLNLKHNQLTSDKLRKLPQHLQVLNLQHN 144
Cdd:PLN00113  71 VVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgpipdDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNN 150

                         90       100
                 ....*....|....*....|....*.
gi 24657947  145 NIT-HLPLELTHMHQLHQLELSHNAI 169
Cdd:PLN00113 151 MLSgEIPNDIGSFSSLKVLDLGGNVL 176
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 112-145 7.13e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 7.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 24657947   112 KGLKRLNLKHNQLTS-DKLRKLPqHLQVLNLQHNN 145
Cdd:pfam12799   1 PNLEVLDLSNNQITDiPPLAKLP-NLETLDLSGNN 34
LRR_8 pfam13855
Leucine rich repeat;
134-170 1.30e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24657947   134 QHLQVLNLQHNNITHLPLE-LTHMHQLHQLELSHNAIN 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLT 38
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 54-171 1.32e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 1.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947  54 STRGLRLTEKTFQSTVPVHSIDLSHLNLTR-LSHLLDKL---PELTSADLSHNQLKDLG--HLGKGLK-------RLNLK 120
Cdd:cd00116  66 IPRGLQSLLQGLTKGCGLQELDLSDNALGPdGCGVLESLlrsSSLQELKLNNNGLGDRGlrLLAKGLKdlppaleKLVLG 145

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24657947 121 HNQLTSDKLRKL------PQHLQVLNLQHNN-----ITHLPLELTHMHQLHQLELSHNAINC 171
Cdd:cd00116 146 RNRLEGASCEALakalraNRDLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLTD 207
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 134-177 1.45e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 24657947   134 QHLQVLNLQHNNITHLPLeLTHMHQLHQLELSHNAINCSCQTLE 177
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNKITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
71-124 2.41e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657947    71 VHSIDLSHLNLTRLS-HLLDKLPELTSADLSHNQLKDLG-----HLGKgLKRLNLKHNQL 124
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPS-LRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
49-104 2.46e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24657947    49 HLKCNSTRGLRltEKTFQSTVPVHSIDLSHLNLTRLS-HLLDKLPELTSADLSHNQL 104
Cdd:pfam13855   7 DLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSpGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 92-127 5.87e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 5.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24657947    92 PELTSADLSHNQLKDLGHLG--KGLKRLNLKHNQLTSD 127
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAklPNLETLDLSGNNKITD 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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