|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
85-552 |
0e+00 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 677.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 85 KMSVFVLTFLAYACYHMCRKPISVVKSVLQGNCSTALAA------SGQDCGYAPFDVPDATTLFGMLDSAFLFSYAIAMF 158
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPPpnivlnNTTWCGWAPFDGKNGTELLGALDSAFLFAYAIGMF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 159 ASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGI 238
Cdd:cd17344 81 FSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 239 WNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPeivgcypqagqherrvanesdveqddeeqv 318
Cdd:cd17344 161 WNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP------------------------------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 319 rhndaeinyrsaptertpilprsqpeavprgrgrpislidalfiPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGP 398
Cdd:cd17344 211 --------------------------------------------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAILSA 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 399 ELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITT 478
Cdd:cd17344 247 KKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPYALITT 326
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24656861 479 SVSAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLISTAGWQYVFHMLIAADIIAMVLLGRLVFKE 552
Cdd:cd17344 327 AVSADLGTHKSLKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
88-549 |
4.45e-92 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 288.06 E-value: 4.45e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 88 VFVLTFLAYACYHMCRKPISVVKS----VLQGNCSTALAASGQDCGYAP--FDVPDATTLF-GMLDSAFLFSYAIAMFAS 160
Cdd:cd17342 4 VFILTFFSYALLHATRKTFSNVKPsisaEWTPSNSNTSIELHEETWNANplFPSQDDAALFlGVLDTIFLFSYAIGLFIS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 161 GFVAERVSLRYFLSMGMILTGVFTYMFG-IARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIW 239
Cdd:cd17342 84 GWLGDRLNLRLVLAFGMCSSAITVFLFGvLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVLGLW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 240 NSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPeivgcypqagqherrvanesdveqddeeqvr 319
Cdd:cd17342 164 SACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP------------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 320 hndaeinyrsaptertpilprsqpeavprgrgrpislidalfiPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPE 399
Cdd:cd17342 213 -------------------------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKES 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 400 LSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGAlSMTISIVLLIVVGIFVNGPYALITTS 479
Cdd:cd17342 250 EADQLSIWYDVGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSPS-DKVLNAFVMTITGFFIGGPANLISSA 328
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24656861 480 VSAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLI-STAGWQYVFHMLIAADIIAMVLLGRLV 549
Cdd:cd17342 329 ISADLGRQPQLRGSSEALATVTGIIDGTGSIGAAIGQVLVPLIqNRLGWMWVFYFFIIMTILTIVCILPLL 399
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
88-545 |
1.65e-80 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 256.82 E-value: 1.65e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 88 VFVLTFLAYACYHMCRKPISVVKSVLQGncstalaasgqdcgyapfDVPDATTLFGMLDSAFLFSYAIAMFASGFVAERV 167
Cdd:cd17312 4 IFLGVFLGYAAYYVCRKNFSVAKPPIVE------------------EIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRS 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 168 SLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGN 247
Cdd:cd17312 66 NIRRFMSAGLLLSALANIFMGFS-----TSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 248 ILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLVDQPeivgcypqagqherrvanesdveqddeeqvrhndaein 326
Cdd:cd17312 141 ILAPILAASLASYyGWRAAFLVPGIVGLVVAIILFFFLRDSP-------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 327 yrsaptertpilprsqpeavprgrgrpislidalfiPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLST 406
Cdd:cd17312 183 ------------------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSS 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 407 LFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLM--YQQYGAlSMTISIVLLIVVGIFVNGPYALITTSVSAEL 484
Cdd:cd17312 227 LYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLalFWFFPH-NKLLSIVLLFLIGFFVGGPINLIGGAAAQDI 305
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24656861 485 GQHsslegnaNALATVTAIIDGTGSIGAAVGPLLAGLISTA-GWQYVFHMLIAADIIAMVLL 545
Cdd:cd17312 306 GRK-------EAAGTATGFVGLFGYLGASLAGLPLGYIIDHyGWSTVFYFLISAALLSVLLL 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
84-549 |
1.23e-40 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 150.79 E-value: 1.23e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 84 YKMSVFVLTFLAYACYHMCRKPISVVKSVLQgncstalaasgqdcgyAPFDVPDATtlFGMLDSAFLFSYAIAMFASGFV 163
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQ----------------ADLGLSAAQ--LGLLASAFFLGYALGQIPAGLL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 164 AERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHT 243
Cdd:COG2271 69 ADRFGRRRVLAIGLLLWGLATLLFGFA-----TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 244 SIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLvdqpeivgcypqagqherrvanesdveqddeeqvrhnd 322
Cdd:COG2271 144 PLGGALAPPLLGWLLAAfGWRAAFLILGLPGLLLALLRFWLL-------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 323 aeinyrsaptertpilprsqpeavprgrgrpislidalfipgvvefSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSA 402
Cdd:COG2271 186 ----------------------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAG 219
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 403 DLSTLFDVGGILGAIAAGYLSD--VSGMSATVCTGMLFVASPILLMYQqygALSMTISIVLLIVVGIFVNGPYALITTSV 480
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDrlGRRRKLVLAIGLLLAALALLLLAL---LPSPALAIALLFLAGFGLGGAFGLLWALA 296
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 481 SAELGQHsslegnanALATVTAIIDGTGSIGAAVGPLLAG-LISTAGWQYVFHMLIAADIIAMVLLGRLV 549
Cdd:COG2271 297 AELFPKK--------ARGTASGLVNTFGFLGGALGPLLVGyLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
143-527 |
3.12e-40 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 150.22 E-value: 3.12e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 222
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS-----TSLWVMAALWALNGIFQGMGWPPCGRT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 223 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES--DWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGcypqagqh 300
Cdd:TIGR00881 108 VTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAElySWHWVFIVPGIIAIIVSLICFLLLRDSPQSCG-------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 301 errvanesdveQDDEEQVRHNDAEINYRSAPTERTPilprsqpeavprgrgRPISLIDALFIPGVVEFSLCLFFTKLVSY 380
Cdd:TIGR00881 180 -----------LPPAEEMPNEEPDGDAEKKEEELTK---------------KQIFLQYVLLNKVLWYISLGYVFVYVVRT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 381 TFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPI--LLMYQQYGALSMTIS 458
Cdd:TIGR00881 234 GILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIvsLLVYWLNPAANPLMD 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 459 IVLLIVVGIFVNGPYALIttsvsaelGQHSSLEGNANALATVTAIIDGTGSIGAAVGPL-LAGLISTAGW 527
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLI--------GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLpLGYLADGFGW 375
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
85-545 |
5.95e-39 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 147.39 E-value: 5.95e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 85 KMSVFVLTFLAYACYHMCRKPISVVKSVLQgncstalaasgQDCGYApfdvpdaTTLFGMLDSAFLFSYAIAMFASGFVA 164
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLI-----------EQYGLS-------KTEIGLIGSALSIAYGLSKFVMGNLS 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 165 ERVSLRYFLSMGMILTGVFTYMFGIArTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWN-SHT 243
Cdd:cd17345 63 DRSNPKRFLAIGLILSAIINILIGFV-PSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNiSHN 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 244 SIGNILGTLI---AAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGCYPqagqherrvanesdVEQDDEEQVRH 320
Cdd:cd17345 142 VGGGLVGPLAglgLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPP--------------IEEYKGDYPEE 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 321 NDAEINYRSAPTertpilprsqpeavprgrgRPISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPEL 400
Cdd:cd17345 208 ADGEEEEQELSA-------------------WEIFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQ 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 401 SADLSTLFDVGGILGAIAAGYLSD--VSGMSATVCTGMLFVASPILLMYQQygALSMTISIVLLIVVGIFVNGPYALItt 478
Cdd:cd17345 269 AMWAFSLFEWAAIPGTLLAGWLSDklFKGRRAPTGIIFMILVIVALIVYWL--APNVLVDLIALIALGFLIYGPVMLI-- 344
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 479 SVSAelgqhssLEGNANALATVTAIIDGTGS--IGAAVGPLLAGLISTA-GWQYVFHMLIAADIIAMVLL 545
Cdd:cd17345 345 GLQA-------LELVPKKAAGTAAGLTGLFGylGGSVLATALIGIIVDHfGWNGGFIVLLASCILAIIFL 407
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
142-545 |
3.10e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 116.52 E-value: 3.10e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 142 FGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVA 221
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-----VSYWLLLLLGLLLGIGGGGSFAVGIA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 222 LVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLVDQPEivgcypqagqh 300
Cdd:COG2223 117 LVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAfGWRNAFLILGILLLVVAVLAWLFLRDPPA----------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 301 errvanesdveqddeeqvrhndaeinyrsaptertpilprsqpEAVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLVSY 380
Cdd:COG2223 186 -------------------------------------------GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 381 TFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSD-VSGMSATVCTGMLFVASPILLMYQQygaLSMTISI 459
Cdd:COG2223 223 GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDrIGGRRVLLIVFALMALGLLLLALAL---GSLWLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 460 VLLIVVGIFVNGPYALITTSVSAELGQHsslegnanALATVTAIIDGTGSIGAAVGPLLAGLI--STAGWQYVFHMLIAA 537
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTK--------NAGAVYGLVGAAGGLGGFLGPLLFGALldATGSYTAAFLVFAVL 371
|
....*...
gi 24656861 538 DIIAMVLL 545
Cdd:COG2223 372 ALVALVLT 379
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
139-548 |
4.19e-28 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 115.36 E-value: 4.19e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 139 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPG 218
Cdd:cd17319 37 PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA-----TSLTSLYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 219 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFvvpgIIIAAVGFLLflflvdqpeivgcypqa 297
Cdd:cd17319 112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLfGWRWAF----IIEGLLGLLL----------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 298 gqherrvanesdveqddeeqvrhndaeinyrsaptertpilprsqpeavprgrgrpiSLIDALFIPGVVEFSLCLFFTKL 377
Cdd:cd17319 171 ---------------------------------------------------------AVLWWFYLRQVWGLALGYFGINY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 378 VSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSD--VSGMSATVCTGMLFVASPILLMyqQYGALSM 455
Cdd:cd17319 194 ALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrlLRGARRLVIIIGLLLAAVGLLL--AYLTTSP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 456 TISIVLLIVVGIFVNGPYALITTSVSAELGqhsslegnANALATVTAIIDGTGSIGAAVGPLLAGLI--STAGWQYVFHM 533
Cdd:cd17319 272 VVAVILLSLAGFGIGAASPVFWSLPADLLP--------GEAAATAGGLINSGGNLGGFVAPLLIGYLvdATGSYTAAFLF 343
|
410
....*....|....*
gi 24656861 534 LIAADIIAMVLLGRL 548
Cdd:cd17319 344 LAAVALLAALLVLLL 358
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
85-545 |
4.23e-26 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 110.50 E-value: 4.23e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 85 KMSVFVLTFLAYACYHMCRKPIS-VVKSVLQGncstalaasgqdcgyAPFDVPDAttlfGMLDSAFLFSYAIAMFASGFV 163
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSfVLPSLMNE---------------LGLDKSDL----GLITSSQSLAYAISKFIGGVL 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 164 AERVSLRYFLSMGMILTGVFTYMFGiarTSNihSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKrgliFGIW---- 239
Cdd:cd17343 62 SDQISARWLFSSGLVLSGLTTVAFS---GSS--SVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQ----FGTWwsvl 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 240 ----NSHTSIGNILGTLIAAHYvesDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGcypqagqherrvanesdVEQDDE 315
Cdd:cd17343 133 stsmNLAGSLGPILATLLALSY---GWRSTLSISGTVAVVMSVVCLLFIKNEPSDVG-----------------LNNIEE 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 316 EQvrhndaeinyrsaptertpilprSQPEAVPRGRGRpISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSST 395
Cdd:cd17343 193 EE-----------------------SKGKKKKSPRGE-STLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 396 LGPELSADLSTLFDVGGILGAIAAGYLSD------------------VSGMSATVCTGMLFvaspiLLMYQQYGALSMTI 457
Cdd:cd17343 249 QSALTGSSFMSSLEVGGFVGSIAAGYLSDwavakhgsssrgnprmplALVFMAGLTVSLHL-----FRVHITSDSSELFI 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 458 SIVLLIvVGIFVNGPYALIttSVSAELGQHSSLEGNANALAtvtaiidgtgSIGAAVGPLLAGL-----ISTAGWQYVFH 532
Cdd:cd17343 324 LLLGFL-IGFSLYGPIAIF--GVIANESAPSHLCGTSHAIV----------ALAANVGGVLAGLpfsyiAKHYDWRTAFL 390
|
490
....*....|...
gi 24656861 533 MLIAADIIAMVLL 545
Cdd:cd17343 391 LLEILCAITVVIL 403
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
140-516 |
1.54e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.89 E-value: 1.54e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 140 TLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGV 219
Cdd:pfam07690 32 TEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA-----SSLWLLLVLRVLQGLGAGALFPAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 220 VALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGiIIAAVGFLLFLFLVDQPEivgcypqag 298
Cdd:pfam07690 107 LALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILA-ILSLLAAVLLLLPRPPPE--------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 299 qherrvanesdveqddeeqvrhndaeinyrsaptertpilpRSQPEAVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLV 378
Cdd:pfam07690 177 -----------------------------------------SKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 379 SYTFMYWLPLYIQKSStLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTIS 458
Cdd:pfam07690 216 FFGLLTYLPLYQEVLG-LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 24656861 459 IVLLIVVGIFVNGPYALITTSVSAELGQHsslegnanALATVTAIIDGTGSIGAAVGP 516
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKE--------ERGTASGLYNTAGSLGGALGP 344
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
143-545 |
1.30e-24 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 106.72 E-value: 1.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQTTGWPGVVAL 222
Cdd:PRK11663 61 GLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSS-----SLWAFALLWVLNAFFQGWGWPVCAKL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 223 VGRWFGKSKRGLIFGIWNSHTSIGNILGTL----IAAHYvesDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGcYPQAG 298
Cdd:PRK11663 136 LTAWYSRTERGGWWAIWNTAHNVGGALIPLvvgaIALHY---GWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMG-LPSVG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 299 QHERrvaNESDVEQDDEeqvrhnDAEINYRSaptertpILPRSqpeavprgrgrpislidALFIPGVVEFSLCLFFTKLV 378
Cdd:PRK11663 212 EWRH---DALELAQQQE------GAGLSRKE-------ILTKY-----------------VLLNPYIWLLSFSYVLVYVV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 379 SYTFMYWLPLYIqkSSTLGPEL-SADLS-TLFDVGGILGAIAAGYLSD--VSG----MSATVCTGMLFVASPILLMyqqy 450
Cdd:PRK11663 259 RAAINDWGNLYM--SETLGVDLvTANSAvSMFELGGFIGALVAGWGSDklFNGnrgpMNLIFAAGILLSVGSLWLM---- 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 451 GALSMTISIVLLIVVGIFVNGPYALIttSVSAELGQHSSLEGNAnalatvTAIIDGTGSIGAAV-GPLLAGLISTAGWQY 529
Cdd:PRK11663 333 PFASYVMQAACFFTIGFFVFGPQMLI--GMAAAECSHKEAAGAA------TGFVGLFAYLGAALsGYPLAKVLEIWHWTG 404
|
410
....*....|....*..
gi 24656861 530 VFHML-IAADIIAMVLL 545
Cdd:PRK11663 405 FFVVIsIAAGISALLLL 421
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
134-545 |
3.66e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 104.43 E-value: 3.66e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 134 DVPDATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQT 213
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA-----PSFWLLLLGRFLLGLGSG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 214 TGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIA---AHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPEi 290
Cdd:cd06174 100 LIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGgilASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPE- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 291 vgcypqagqherrvanesdveqddeeqvrhndaeinyrsaptertpilPRSQPEAVPRGRGRPISLIDALFIPGVVEFSL 370
Cdd:cd06174 179 ------------------------------------------------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 371 CLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYqqY 450
Cdd:cd06174 211 AIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALL--L 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 451 GALSMTISIVLLIVVGIFVNGPYALITTSVsaelgqhsSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLIS--TAGWQ 528
Cdd:cd06174 289 LAPSLLLLLLLLLLLGFGLGGLLPLSFALI--------AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaaTFGLT 360
|
410
....*....|....*..
gi 24656861 529 YVFHMLIAADIIAMVLL 545
Cdd:cd06174 361 GAFLVLAVLLLLAAILL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
143-549 |
6.51e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 97.65 E-value: 6.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 222
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA-----TSYWQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 223 VGRWFGKSKRGLIFGIWNSHTSIGNI----LGTLIAAHYvesDWALSFVVPGIIIAAVGFLLFLFLvdqpeivgcypqag 298
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLigplLGGLLADAL---GYRAPFLVCAALALLALVLALLLL-------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 299 qherrvanesdveqddeeqvrhndaeinyrsaptertPILPRSQPEAVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLV 378
Cdd:cd17325 172 -------------------------------------PEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 379 SYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQqygALSMTIS 458
Cdd:cd17325 215 FGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL---ATSFWLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 459 IVLLIVVGIFvngpYALITTSVSAELgqhsSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLIS-TAGWQYVFHMLIAA 537
Cdd:cd17325 292 LLLLALLGLG----LGLVFPATLALL----ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAAL 363
|
410
....*....|..
gi 24656861 538 DIIAMVLLGRLV 549
Cdd:cd17325 364 LLLAAVLFLLLR 375
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
79-545 |
7.10e-22 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 97.48 E-value: 7.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 79 RRDLLYKMsvfvltFLAYACYHMCRKPISVVKSVLQGNCStalaasgqdcgyapFDVPDattlFGMLDSAFLFSYAIAMF 158
Cdd:cd17488 1 RIHILASM------FIGYAVFYLTRKSFNAAMPAMLADLG--------------LDKSD----IGILGSLFYITYGVSKF 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 159 ASGFVAERVSLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGI 238
Cdd:cd17488 57 VSGLMSDRSNPRYFMGIGLIATGIINILFGFSS-----SLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSI 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 239 WNSHTSIGNILGTLI---AAHYveSDWALSFVVPGIIIAAVGFLLFLFLVDQPeivgcypqagqherrvanesdveqdde 315
Cdd:cd17488 132 WNTSHNIGGALIPILtgfAALT--YGWRAGMYVPGIIAILMGIVLCWRLRDRP--------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 316 eqvrhndaeinyrsaptertpilprsqpeavprgrgrpislidalfiPGVVEFSLCLFFTKLVSYTFMYWLPLYIqkSST 395
Cdd:cd17488 183 -----------------------------------------------PYIWLLAFCYVLVYVVRTAINDWGNLYL--SET 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 396 LGPEL-SADLS-TLFDVGGILGAIAAGYLSDVSGMSATVCTGMLF-------VASPILLMYQQYgalsmTISIVLLIVVG 466
Cdd:cd17488 214 HGYSLvKANSAvSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFalgllvsVGALWLVPVHSY-----WLLATCFFTIG 288
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 467 IFVNGPYALITTSvSAELGqHSSLEGNAnalatvtaiidgTGSIG--AAVGPLLAG-----LISTAGWQYVFHMLIAADI 539
Cdd:cd17488 289 FFVFGPQMLIGMA-AAECS-HKDAAGSA------------TGFVGlfAYLGAALAGyplakVIESWGWSGFFIVISIAAA 354
|
....*.
gi 24656861 540 IAMVLL 545
Cdd:cd17488 355 ISGLLL 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
139-514 |
1.50e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 96.20 E-value: 1.50e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 139 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPG 218
Cdd:COG2814 44 PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA-----PSLWLLLAARFLQGLGAGALFPA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 219 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFlvdqpeivgcypqa 297
Cdd:COG2814 119 ALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLLRL-------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 298 gqherrvanesdveqddeeqvrhndaeinyrsaptertpiLPRSQPEAVPRGRGrpiSLIDALFIPGVVEFSLCLFFTKL 377
Cdd:COG2814 185 ----------------------------------------LPESRPAARARLRG---SLRELLRRPRLLLLLLLAFLLGF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 378 VSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQqygALSMTI 457
Cdd:COG2814 222 GFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWL 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 24656861 458 SIVLLIVVGIFVNGPYALITTSVSAELGQHsslegnanALATVTAIIDGTGSIGAAV 514
Cdd:COG2814 299 LLLALFLLGFGFGLLFPLLQALVAELAPPE--------ARGRASGLYNSAFFLGGPL 347
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
79-561 |
2.87e-21 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 97.04 E-value: 2.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 79 RRDLLYK--MSVFVLTFLAYACYHMCRKPISVVKSVLQgncstalaasgQDCGYApfdvpdaTTLFGMLDSAFLFSYAIA 156
Cdd:PRK09556 19 QRKMWFKpfMQSYLVVFIGYLTMYLIRKNFKAAQNDMI-----------STYGLS-------TTELGMIGLGFSITYGVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 157 MFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIF 236
Cdd:PRK09556 81 KTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 237 GIWNSHTSIGNILGTLIA---AHYV-ESDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGCypqaGQHERRVANESDVEQ 312
Cdd:PRK09556 161 GFWNISHNLGGAGAGGVAlwgANYFfDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEELGW----GKAEEIFGEPISEED 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 313 DDEEQVRHNDAEINYRsaptertpilprsqpeavprgrgrpislidaLFIPGVVEFSLCL--FFTKLVSYTFMYWLPLYI 390
Cdd:PRK09556 237 KETESTDMTKWQIFVE-------------------------------YVLKNPVIWLLCFanIFLYIVRIGIDNWSPVYA 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 391 QKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSG----MSATVCTGMLFVAspiLLMYQQygALSMTISIVLLIVVG 466
Cdd:PRK09556 286 FQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANgrraLVACIALALIIFT---LGVYQH--ATSEYMYLASLFALG 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 467 IFVNGPYALITTSV------------SAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLaglistAGWQYVFHML 534
Cdd:PRK09556 361 FLVFGPQLLIGVAAvgfvpkkaigvaNGIKGTFAYLFGDSFAKVGLGMIADPTKNGTPIFGYTL------TGWAGTFAAL 434
|
490 500
....*....|....*....|....*..
gi 24656861 535 IAADIIAMVLLGRLVFKEFAALRRASH 561
Cdd:PRK09556 435 DIAAIGCICLMAIVAVMEERKIRREKK 461
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
142-520 |
1.68e-19 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 90.88 E-value: 1.68e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 142 FGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQTTGWPGVVA 221
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT-----NVTQLLILRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 222 LVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLvdqPEivgcyPQAGQH 300
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVfGWRSLFYVGGIAPLLLLLLLMRFL---PE-----SIDFLV 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 301 ERRvanesdveqDDEEQVRHNDAEINYRSAPTERTPILPRSQPEAVprgrgrpiSLIDALFIP----GVVEFSLCLFFTK 376
Cdd:TIGR00895 201 SKR---------PETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKR--------SVFKALFQGktarITVLLWLLYFMLL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 377 LVSYTFMYWLPlYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGmSATVCTGMLFVASPILLMYQQYGalSMT 456
Cdd:TIGR00895 264 VGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLG-PRVTALLLLLGAVFAVLVGSTLF--SPT 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24656861 457 ISIVLLIVVGIFVNGPYalitTSVSAELGQHSSLEGNANALATVTAIidgtGSIGAAVGPLLAG 520
Cdd:TIGR00895 340 LLLLLGAIAGFFVNGGQ----SGLYALMALFYPTAIRATGVGWAIGI----GRLGAIIGPILAG 395
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
140-548 |
1.53e-17 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 84.92 E-value: 1.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 140 TLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGV 219
Cdd:COG2807 53 TQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA-----PSVALLLAGTALIGAGIAVGNVLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 220 VALVGRWFGKsKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVpGIIIAAVGFLLFLFLVDQPeivgcypqag 298
Cdd:COG2807 128 PGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAAlGWRGALAV-WALLALLALLLWLPLLRRR---------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 299 qherrvanesdveqddeeqvrhndaeinyrsaptertpilPRSQPEAVPRGRGRPIslidaLFIPGVVEFSLCLFFTKLV 378
Cdd:COG2807 196 ----------------------------------------PAAAAAAPAAASLRSL-----WRSPLAWLLTLFFGLQSLL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 379 SYTFMYWLPLYIQkSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGM--LFVASPILLMYqqygaLSMT 456
Cdd:COG2807 231 YYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLglLGLAGLLGLLL-----APGS 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 457 ISIVLLIVVGIFVNGPYALITTSVSAELGqhsslegNANALATVTAIIDGTGSIGAAVGPLLAGLI--STAGWQYVFHML 534
Cdd:COG2807 305 LPWLWAVLLGLGQGGLFPLALTLIGLRAR-------TPAEAAALSGMAQSVGYLLAALGPLLVGALhdATGSWTAALLLL 377
|
410
....*....|....
gi 24656861 535 IAADIIAMVLLGRL 548
Cdd:COG2807 378 AALAVLMLVAGLLA 391
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
133-551 |
1.43e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 81.82 E-value: 1.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 133 FDVPDATTlfGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQ 212
Cdd:COG0738 38 FGLSDAQA--GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA-----PSYPLLLLALFLLGLGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 213 TTGWPGVVALVGRWFGKSKRGLI--FGIWNShtsIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVdqpei 290
Cdd:COG0738 111 GLLDVAANPYVAALGPETAASRLnlLHAFFS---LGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL----- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 291 vgcypqagqherrvanesdveqddeeqvrhndaeinyrsapteRTPiLPRSQPEAVPRGrGRPISLIDALFIPGVVEFSL 370
Cdd:COG0738 183 -------------------------------------------RSK-LPEIEEEEEEAA-GSAASLKSLLKNPRLLLGGL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 371 CLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQqy 450
Cdd:COG0738 218 AIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALL-- 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 451 gALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSslegnanalATVTAIIDGTGSIGAAVGPLLAGLIS-TAGWQY 529
Cdd:COG0738 296 -APGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT---------AAAVSAVLIMGIVGGAIGPPLIGFLAdAFGLRA 365
|
410 420
....*....|....*....|..
gi 24656861 530 VFHMLIAAdIIAMVLLGRLVFK 551
Cdd:COG0738 366 AFLVPLVC-YLLILLLALALKR 386
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
143-545 |
3.13e-15 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 77.66 E-value: 3.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFtyMFGIARTsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 222
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAA--ALLMALV---GSYPVLLVLLFLVGAGYGSVQPGGGRA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 223 VGRWFGKSKRGLIFGIWNSHTSIGNILGTL----IAAHYvesDWALSFVVPGIIIAAVGFLLFLFLVDQPEIvgcypqag 298
Cdd:cd17475 109 IMRWFPPRERGLAMGIRQTGVPLGGALAAAllppLALHY---GWRAAFVVAGLVSILAAVLFWLFYREPPAA-------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 299 qherrvanesdveqddeeqvrhndaeinyrSAPTERTPILPRSQPEAVprgRGRPISLIdalfipGVVEFSLCLFFTKLV 378
Cdd:cd17475 178 ------------------------------SAATESASTLLRSLKEVL---RNRDVWLI------AIAGALLVAPQFALL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 379 SYtfmywLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSD-------VSGMSATVCTGMLFVASPILLMYQQYG 451
Cdd:cd17475 219 TF-----LLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDrvfggrrRPVLVITAAIAAAALLVLSLLSPGTPL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 452 ALSMTISIVLlivvGIFVNGPYALITTSVSAELGQHSSleGNANALATVTAiidgtgSIGAAVGPLLAGLI--STAGWQY 529
Cdd:cd17475 294 WLLVLLLILL----GLFAIGWNGLYLTLVAESAGPEQA--GTALGLANTIN------FIGIAIGPPLFGLLvdATHSYAP 361
|
410
....*....|....*.
gi 24656861 530 VFHMLIAADIIAMVLL 545
Cdd:cd17475 362 AWLALALLLVLAALLL 377
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
88-545 |
6.42e-15 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 77.06 E-value: 6.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 88 VFVLTFLAYACYHMCRKPISVVKSVL--QGncstalaASGQDCGYAPfdvpdattlfgmldSAFLFSYAIAMFASGFVAE 165
Cdd:PRK11273 30 IFLGIFFGYAAYYLVRKNFALAMPYLveQG-------FSRGDLGFAL--------------SGISIAYGFSKFIMGSVSD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 166 RVSLRYFLSMGMILTGVFTYMFGIA--RTSNIHSLwyFIIVQIfAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWN-SH 242
Cdd:PRK11273 89 RSNPRVFLPAGLILAAAVMLFMGFVpwATSSIAVM--FVLLFL-CGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNcAH 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 243 TSIGNILGTL-IAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGCYPqagQHERRVANESDVEQDDEEQVRHN 321
Cdd:PRK11273 166 NVGGGLPPLLfLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPP---IEEYKNDYPDDYNEKHEQELTAK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 322 DAEINYrsaptertpILPRsqpeavprgrgrpiSLIDALFIPGVvefslclfFTKLVSYTFMYWLPLYIQKSSTLGPELS 401
Cdd:PRK11273 243 QIFMQY---------VLPN--------------KLLWYIAIANV--------FVYLLRYGILDWSPTYLKEVKHFALDKS 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 402 ADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPIL--LMYQQYGALSMTISIVLLIVVGIFVNGPYALItts 479
Cdd:PRK11273 292 SWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIatIVYWLNPAGNPTVDMACMIVIGFLIYGPVMLI--- 368
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24656861 480 vsaelGQHsSLEGNANALATVTAIIDGT-GSIGAAVGP--LLAGLISTAGWQYVFHMLIAADIIAMVLL 545
Cdd:PRK11273 369 -----GLH-ALELAPKKAAGTAAGFTGLfGYLGGSVAAsaIVGYTVDFFGWDGGFMVMIGGSILAVILL 431
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
133-544 |
7.50e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 73.35 E-value: 7.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 133 FDVPDATTlfGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQ 212
Cdd:cd17324 29 FGVSVAQA--GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA-----PSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 213 TTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILG----TLIAAHYvesDWALSFVVPGIIIAAVGFLLFLFLVDQP 288
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGrplgGLLGQLL---GWRAAFLAIAVLALLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 289 eivgcypqagqherrvanesdveqddeeqvrhndaeinyrsAPTERTPILPRSQPEAVPRGRGRPISLIdalfipgvvef 368
Cdd:cd17324 179 -----------------------------------------PKKPGSLGLLSSLLLLLRNPRLRLAYLI----------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 369 SLCLFFTKLVSYTFMywlPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMyq 448
Cdd:cd17324 207 TFLLFGGFFALYTYL---APFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLT-- 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 449 qYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSLegnANALATVTAiidgtgSIGAAVGPLLAGL-ISTAGW 527
Cdd:cd17324 282 -LLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGL---ASSLYLAAY------NLGGALGAALGGLvLDHGGW 351
|
410
....*....|....*..
gi 24656861 528 QYVFHMLIAADIIAMVL 544
Cdd:cd17324 352 AGVGWVGAALLLLALLL 368
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
139-523 |
1.40e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 72.65 E-value: 1.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 139 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTymfgiARTSNIHSLWYFIIVQIFAGIFQTTGWPG 218
Cdd:cd17328 33 DSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAAT-----LLSSFAPNFWQLLLFRALVGIGEASYSPI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 219 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILG----TLIAAHYVesDWALSFVVPGIIIAAVGFLLFLFLVDQpeivgcy 294
Cdd:cd17328 108 APTIIADLFPKEKRTRALGVFYFAIPLGSGLGyvvgGLVAQATG--GWRWAFRVTGVLGVLLAILLLLFVREP------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 295 pqagqherrvanesdveqddeeqvrhndaeinyrsaptertpilPRSQPEAVPRGRGRPISLIDALFI----PGVVEFSL 370
Cdd:cd17328 179 --------------------------------------------PRGAAEGGVMAKSTATSFLADLKAlaknPSFILSTL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 371 CLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFD----VGGILGAIAAGYLSDVSGMS-----ATVCTGMLFVAS 441
Cdd:cd17328 215 GFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGaitcIAGVLGVLLGGILADRLRRKtpradPLVCAVGLLAAA 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 442 PILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELgqHSSLEGNANALATVTaiidgTGSIGAAVGPLLAGL 521
Cdd:cd17328 295 PFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVV--IPTRRSTASAIQILL-----SHLLGDAGSPYLIGL 367
|
..
gi 24656861 522 IS 523
Cdd:cd17328 368 IS 369
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
143-548 |
2.59e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 2.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 222
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS-----DSFALLLAGRALQGIGAAGLGPLALTL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 223 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIaAVGFLLFLFLVDQPeivgcypqagqher 302
Cdd:cd17474 112 IGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALI-PVAFLAILFLLPEP-------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 303 rvanesdveqddeeqvrhndaeinyrSAPTERTPILPRSQPEAVPRGRGRPISLIDALFipgvveFSLCLFftklvsyTF 382
Cdd:cd17474 177 --------------------------KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFL------YFFLYF-------AF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 383 MYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDV-SGMSATVCTGM-LFVASPILLMYqqygALSMTISIV 460
Cdd:cd17474 218 LTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLlLYALSLLLLGF----VPSLALLLI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 461 LLIVVGIFVNGPYALITTSVSAELGQHSslegnanaLATVTAIIDGTGSIGAAVGPLLAGLI-STAGWQYVFHMLIAADI 539
Cdd:cd17474 294 AIVLFGLGLGLNLPLLTTLVTELAPEEE--------RGTASSLYNFVRFLGQAVGPLLFGLLlEIFGLSAPFLVGAAIAL 365
|
....*....
gi 24656861 540 IAMVLLGRL 548
Cdd:cd17474 366 AAAVLLALL 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
139-284 |
1.27e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 1.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 139 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQTTGWPG 218
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-----SFWLLLLLLALLGLGLGLVFPA 308
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24656861 219 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFL 284
Cdd:cd17325 309 TLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAfGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
143-522 |
1.90e-11 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 65.81 E-value: 1.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFL--SMGMILTGVFTYMFGiartsnihSLWYFIIVQIF-----AGIFQTTG 215
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLilGLLLISLALALIFAT--------PSIYLFVVLMFlaglgAGILDTGA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 216 WPGVVALvgrwfGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVesDWALSFVVPGIIIAAVGFLLFLFLVDqpeivgcyp 295
Cdd:cd17333 106 NTFVGAL-----FEESSATRLNVLHGFFGLGALIGPLIATSLL--TSELSWSWAYLIIGLIYLLLAILILL--------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 296 qagqherrvanesdVEQDDEEQVRHNDAEINYRSAPTertpilprsqpeavprgrgrpislIDALFIPGVVEFSLCLFFT 375
Cdd:cd17333 170 --------------TLFPELPSARNPQQSVGAFSASA------------------------SRLLRNPSIILGALALFLY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 376 KLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVctgMLFVASPILLMYQQYGALSM 455
Cdd:cd17333 212 VGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLL---VLSGSGALLGLLILLLAPTL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24656861 456 TISIVLLIVVGIFVNGPYALITTSVSAELGQHSSlegnanalaTVTAIIDGTGSIGAAVGPLLAGLI 522
Cdd:cd17333 289 VVGLVATALLGLFMAALFPTILSLGISNLPYAKG---------KGTSVLLAAGSIGGAIIPFIMGFI 346
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
90-554 |
2.68e-11 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 65.33 E-value: 2.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 90 VLTFLAYACYHMCRKPIS------VVKSVLQGNCSTALAASGQDCGYAPFDVPDATTlfGMLDSAFLFSYAIAMFASGFV 163
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSvaivamVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQ--GIILSSFFYGYILTQIPGGYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 164 AERVSLRYFLSMGMILTGVFTYMFGIArtSNIHSLWYfIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHT 243
Cdd:cd17318 80 AEKYGAKRVLGYSILITALLTLLTPLA--ARGGYGAL-IVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 244 SIGNILGTLIAAHYVES-DWALSFVVPGiIIAAVGFLLFLFLVdqpeivgcypqagqherrvanesdveqddeeqvrhnd 322
Cdd:cd17318 157 QFGTVIAMPLSGFLCESlGWPSIFYIFG-GLGLLWCLLWFFLV------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 323 aeinyrsaptertpilprsqpeavprgrgRPI-SLIDALFipgvvefslCLFFTklvSYTFMYWLPLYIqkSSTLGPELS 401
Cdd:cd17318 199 -----------------------------LPVwAIVVAHF---------GHNWG---FYTLLTELPTYM--SDVLHFNIK 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 402 AD--LSTLFDVGGILGAIAAGYLSDV----SGMSAT----VCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNG 471
Cdd:cd17318 236 SNgfLSSLPYLAMWICSIVGGYLADWlrsrGILSTTtvrkLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGA 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 472 PYALITTSVsaelgqhssLEGNANALATVTAIIDGTGSIGAAVGPLLAGLI-----STAGWQYVFhmLIAAdiiAMVLLG 546
Cdd:cd17318 316 CYSGFLVNH---------LDLAPNYAGTLMGITNTAATIAGIISPLIVGAIvkndqTIGQWRIVF--FISA---AIYILG 381
|
....*...
gi 24656861 547 RLVFKEFA 554
Cdd:cd17318 382 AIFYLIFG 389
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
147-289 |
5.46e-11 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 64.58 E-value: 5.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 147 SAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMfgiarTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRW 226
Cdd:cd17327 48 TVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLL-----TAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 227 FGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESD-------WALSFVVPGIIIAAVGFLLFLFLVDQPE 289
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILgvgglagWRWLFIIEGLITIIIGLVIFFWLPDNPS 192
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
143-545 |
4.06e-10 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 61.93 E-value: 4.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQTTGWPGVVAL 222
Cdd:cd17371 37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ-----NYWQLLILRALAGLGFGGEWAAGAAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 223 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAA-----HYVESDWALSFVVpGIIIAAVGFLLFLFLVDQPEIvgcypQA 297
Cdd:cd17371 112 MAEYVPARHRGKALGYVQSGWAVGWLLATLLAAllfplLPPEIAWRVLFLL-GALPALLVLFIRRFVKEPPQW-----QA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 298 GQHERRVAnesdveqddeeqvrhndaeinyrsaptertpiLPRSQPEAVPRGRGRPISLIDALFipgvvefSLCLFFTkl 377
Cdd:cd17371 186 ARAARRHF--------------------------------ADRPSLRELFSPPLLRTTLLASLL-------ATGALGG-- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 378 vSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQqyGALSMTI 457
Cdd:cd17371 225 -YYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFF--LPLSPTL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 458 SIVLLIVVGIFVNGPYALITTSVSaELGQhsslegnANALATVTAIIDGTGSIGAAVGPLLAGLISTAG-WQYVFHMLIA 536
Cdd:cd17371 302 ILILGFPLGFFASGPFSGMGAYLT-ELFP-------TAVRATAQGFCYNVGRIIGALFPFLVGFLATSGsLGTAIAVFAA 373
|
....*....
gi 24656861 537 ADIIAMVLL 545
Cdd:cd17371 374 VYYIAGLVL 382
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
143-545 |
1.12e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 60.26 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 222
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA-----PNYWLLLLLVALAGIGSAAFHPEGARL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 223 VGRwFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPEivgcypqagqher 302
Cdd:cd17478 109 ASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 303 rvanesdVEQDDEEQVRHNDAEInyrsaptertpilprsqpeavpRGRGRPISLIDALFipgvveFSLCLFFTKLVSYtf 382
Cdd:cd17478 175 -------PEAKKAAAKSSARSTL----------------------KGVWRALLLLLIIV------FLRSWVLSSLTTF-- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 383 mywLPLYIqKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGalsmTISIVLL 462
Cdd:cd17478 218 ---LPFYL-VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG----IWSYILL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 463 IVVGIFVNGPYALITTSVSAELGQHSSLegnANALatVTAIIDGTGSIGAAVgplLAGLISTAGWQYVFHMLIAADIIAM 542
Cdd:cd17478 290 VLAGFLLFASFPVTVVLAQELLPGNVGL---ASGL--MMGLSFGLGGIGAPV---LGALADAFGLESVLLILALLPLLGA 361
|
...
gi 24656861 543 VLL 545
Cdd:cd17478 362 LLA 364
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
356-548 |
1.20e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 60.29 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 356 LIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPlYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTG 435
Cdd:cd17365 164 LILLPLLRGTLLLWVTFFMGLLLVYLLNSWLP-KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALF 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 436 MLFVAspILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTsVSAELGQhsslegnANALATVTAIIDGTGSIGAAVG 515
Cdd:cd17365 243 FALGA--VSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYA-LAARFYP-------TEVRATGVGWALGVGRLGAILG 312
|
170 180 190
....*....|....*....|....*....|....*...
gi 24656861 516 PLLAGLISTAGWQY--VFHML---IAADIIAMVLLGRL 548
Cdd:cd17365 313 PLLGGLLLAAGLGPesVFLALaipAALGALAVLLLRLR 350
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
154-522 |
2.35e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.53 E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 154 AIAMFASGFVAERVSLRY-----FLSMGMILTGVFTYMFGIART-SNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWF 227
Cdd:COG2211 60 AITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 228 GKSK-RGLIFGIWNSHTSIGNILGTLIAA---HYVESDWALSFVVPGIIIAAVGFLLFLFLVdqpeivgcypqAGQHERR 303
Cdd:COG2211 140 PDYEeRTRLSSWRFAFAGLGGLLASVLPPplvAAFGGDAALGYRLTALIFAVLGLLAFLLTF-----------FGTKERP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 304 VANEsdveqddeeqvrhndaeinyrsaptERTPILPrsqpeavprgrgrpiSLIDALFIPGVVEFSLCLFFTKLVSYTFM 383
Cdd:COG2211 209 VPEE-------------------------EKVSLKE---------------SLKALLKNRPFLLLLLAYLLFFLALALVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 384 YWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYqQYGALSMTISIVLLI 463
Cdd:COG2211 249 ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF-FLGPGNLWLLLVLAA 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 24656861 464 VVGIFVnGPYALITTSVSAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLI 522
Cdd:COG2211 328 LAGIGL-GAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
138-545 |
2.53e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.15 E-value: 2.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 138 ATTLFGMLDSAFLFsyaiamfasGFVAERVSLRYFLSMGMILTGVFTymFGIARTSNIhslWYFIIVQIFAGIFQTTGWP 217
Cdd:cd17316 43 AAGFLGRPIGALLF---------GYLGDRIGRKKALILTLLLFGLAT--LLIGLLPTP---ILLLVLRFLQGIGIGGEYP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 218 GVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIA-----AHYVESDWALSFVVpGIIIAAVGFLLflflvdqpeivg 292
Cdd:cd17316 109 GASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAsllipLLSGDWGWRILFLI-GALPALLALLL------------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 293 cypqagqherrvanesdveqddeeqvrhndaeinyrsaptertpilprsqpeavprgrgRPISLIDALFIpgvvefslcl 372
Cdd:cd17316 176 -----------------------------------------------------------RRRTLLLILLW---------- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 373 FFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGML--FVASPILLMYQQY 450
Cdd:cd17316 187 FFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIlsGILALPLFYLLSG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 451 GALSMTISIVLLIVVGIFVNGPYALITTSVSAelgqhsslegnANALATVTAIIDGTGSIGAAVGPLLAG--LISTAGWQ 528
Cdd:cd17316 267 SPTLLLLLLFILSFFVGGVWGALYAYLAELFP-----------TEVRATGVGLSYNLGRLGGGGAPPLIAllLASTGGTG 335
|
410
....*....|....*..
gi 24656861 529 YVFHMLIAADIIAMVLL 545
Cdd:cd17316 336 VPALILALLAIVALIVA 352
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
143-285 |
3.22e-09 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 58.72 E-value: 3.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLwyfIIVQIFAGIFQTTGWPGVVAL 222
Cdd:cd17380 37 GLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLL---ILSRILLGLGEGVHFPSMTSL 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24656861 223 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVE-SDWALSFVVPGIIiaavGFLLFLFLV 285
Cdd:cd17380 114 FSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEyYGWPSVFYFFGLL----GLLWALVWL 173
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
368-545 |
3.66e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.58 E-value: 3.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 368 FSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMY 447
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 448 QqygALSMTISIVLLIVVGIFVNGPYALITTSVSAELGqhsslegnANALATVTAIIDGTGSIGAAVGPLLAGLISTA-G 526
Cdd:pfam07690 81 F---ASSLWLLLVLRVLQGLGAGALFPAALALIADWFP--------PEERGRALGLVSAGFGLGAALGPLLGGLLASLfG 149
|
170
....*....|....*....
gi 24656861 527 WQYVFHMLIAADIIAMVLL 545
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLL 168
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
139-284 |
1.03e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 56.74 E-value: 1.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 139 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPG 218
Cdd:COG0477 48 SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA-----PSPELLIAARALQGIGAGGLMPG 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24656861 219 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVpGIIIAAVGFLLFLFL 284
Cdd:COG0477 123 ALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAlGWRWIFLI-NAPLGLLALVLRLRL 188
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
137-286 |
1.17e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.60 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 137 DATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNihsLWYFIIVQIFAGIFQTTGW 216
Cdd:COG2211 261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN---LWLLLVLAALAGIGLGAIL 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 217 PGVVALV------GRW-FGKSKRGLIFGIWNSHTSIGNILGTLIA----------------AHYVESDWALSFVVPGIII 273
Cdd:COG2211 338 VLPWAMLadvvdyDEWkTGRRREGLYFGIFTFAIKLGQALAGALAglllalfgyvagaaqsPSALTGIRLLFFLLPAVLL 417
|
170
....*....|...
gi 24656861 274 AAVGFLLFLFLVD 286
Cdd:COG2211 418 LLAALLLLFYPLT 430
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
353-526 |
1.19e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.18 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 353 PISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATV 432
Cdd:cd17321 158 PIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 433 CTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSlegnanalATVTAIIDGTGSIGA 512
Cdd:cd17321 238 VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKA--------GAASGILNTARQLGG 309
|
170
....*....|....
gi 24656861 513 AVGPLLAGLISTAG 526
Cdd:cd17321 310 ALGVALLGALLTAG 323
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
154-545 |
1.26e-08 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 57.26 E-value: 1.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 154 AIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsnIHSLWYFIIVQIFAGIFQTTGWPGVVaLVGRWFGKSKRG 233
Cdd:cd17341 48 ALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALA----VSSYWGLLVLGFLLGFAGANFASGQP-WASFWFPKEKIG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 234 ----LIFGIWNSHTSIGNILGTLIAAHYVESD----WALSFVVPGIIIAAVGFLLFLFLVDQPEIvgcypqagqherrva 305
Cdd:cd17341 123 gaagGIAGAGNMGVAVSQLLAPLIAGAIVFDGgfvgWRNAFFVPGILLAIAAVLVLLFGDDLPTG--------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 306 nesdveqddeeqvrhndaeinyrsaptertpilPRSQPEAVPRgrgrpisLIDALFIPGVVEFSLCLFFTKLVSYTFMYW 385
Cdd:cd17341 188 ---------------------------------KASALEFLKV-------QLAVLKNYRTWILSLLYGVTFGSFVGFSNV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 386 LPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATvcTGMLFV----ASPILLMYQQYGALSMTISIVL 461
Cdd:cd17341 228 LPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRR--LWWLFIvmtiGAALLSLSLPTSGTNLVLFLAL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 462 LIVVGIFVNGPYALITTSVSAELGqhsslegnaNALATVTAIIDGTGSIGAAVGPLLAGLISTAGWQYVFH-MLIAADII 540
Cdd:cd17341 306 FVALGLGAGAGNGSVFRMVPFIFR---------RELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAfSLFGVLAV 376
|
....*
gi 24656861 541 AMVLL 545
Cdd:cd17341 377 ACTLL 381
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
147-548 |
3.11e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 55.74 E-value: 3.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 147 SAFLFSYAIAMFASGFVA-------ERVSLRYFLSMGMILTGVftymfGIARTSNIHSLWYFIIVQIFAGIFQ--TTGWP 217
Cdd:cd17355 38 AVISLAFTVGLLAFGLAQpfvgrllDRFGPRRVMLLGLLLLAA-----GLVLLALATSLWQLYLLWGLLGGGGagTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 218 GVVALVGRWFGKsKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLFLVDQPeivgcypq 296
Cdd:cd17355 113 AFATVAAWWFER-RRGLALGILTAGGGLGSLVFLPLGAALIEAfGWRTALLVLALLALLVLVPVLLLLRRRP-------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 297 agqherrvanesdveqddeeqvrhndAEINYRSAPTERTPILPRSQPEAVPRGRGRPISLIdalfipgvveFSLCLFFTk 376
Cdd:cd17355 184 --------------------------ADLALRAYDDASPASPGSTLKEALRSASFWLLALA----------FFLCGFAV- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 377 lvsYTFMYWLPLYIQkSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGM-LFVASPILLMYQQYGALSM 455
Cdd:cd17355 227 ---VGLIVHLVPYLA-DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYaLRALGLALLLLLPFPPLAL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 456 tisIVLLIVVGIFVNGPYALITTSVSAELGQHSslegnanaLATVTAIIDGTGSIGAAVGPLLAGLISTAGWQY--VFHM 533
Cdd:cd17355 303 ---LLFAALFGLGWGATVPLTAALAARYFGARS--------YGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYtaAWAL 371
|
410
....*....|....*
gi 24656861 534 LIAADIIAMVLLGRL 548
Cdd:cd17355 372 AVALGLIAALLVLPI 386
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
338-526 |
2.82e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 53.04 E-value: 2.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 338 LPRS-QPEAVPRGRGRPISLIDALFIPGVVEFSLCL----FFTKLVSYTFMYWLPLYIQkSSTLGPELSADLSTLFDVGG 412
Cdd:PRK11551 190 LPESrAFAQAAGAGKQRAPVLRALFGEGRATATLLLwisyFFTLIVLYFLLNWLPSLLV-GQGLSRSQAGLVQIAFNIGG 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 413 ILGAIAAGYLSDVSGMSATVctgmLFVASPILLmyqQYGALSMTISIVLLIVV----GIFVNGP----YALITTSVSAEL 484
Cdd:PRK11551 269 ALGSLLIGALMDRLRPRRVV----LLIYAGILA---SLAALAAAPSFAGMLLAgfaaGLFVVGGqsvlYALAPLFYPTQV 341
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 24656861 485 gqhsslegNANALATVTAIidgtGSIGAAVGPLLAGLISTAG 526
Cdd:PRK11551 342 --------RGTGVGAAVAV----GRLGSMAGPLLAGQLLALG 371
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
147-289 |
6.88e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 51.84 E-value: 6.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 147 SAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGvftymFGIARTSNIHSLWYFIIVQ-IFAGIFQTTGWPGVVALVGR 225
Cdd:cd17353 45 TLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG-----LGFILSAFAISLPLLFLGYgVLGGIGAGIGYITPVSTAVK 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24656861 226 WFgKSKRGLIFGIWNSHTSIGNILGTLIAAHYVE-SDWALSFVVPGIIIAAVGFLLFLFLVDQPE 289
Cdd:cd17353 120 WF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINtVGVPTTFLILGIIFLIIIVIGAFLIRDPPK 183
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
141-540 |
3.39e-06 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 49.74 E-value: 3.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 141 LFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIhslwyfiIVQIFAGIFQTTGWPGVV 220
Cdd:TIGR00894 77 LQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGI-------ALVVFCRVIQGLAQGSVS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 221 ----ALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESD--WALSFVVPGIIIAAVGFLLFLFLVDQPEIvgcY 294
Cdd:TIGR00894 150 pathKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWggWPMIFYVFGIVGCAWSLLWFVFPADDPSI---H 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 295 PQAGQHERRVANESDVEQDdeeqvrhndaEINYRSAPTertpilprsqpeavprgRGRPISLidalfipGVVEFSLCLFF 374
Cdd:TIGR00894 227 PCISKFEKKYINSSLQGQK----------GSTRQSLPI-----------------KAIPKSL-------PVWAIWFAIFG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 375 TKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSAT--------VCTGMLFVASPILLM 446
Cdd:TIGR00894 273 HFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTlsltaarkIFNGIGGLGPGIFAY 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 447 YQQYGALSMTISIVLLIVVGIFVNGPYALITTsvsaelgqhSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLISTAG 526
Cdd:TIGR00894 353 ALPYLSAAFYLTIIILTLANAVSSGPLAGVLI---------NSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQD 423
|
410
....*....|....*...
gi 24656861 527 ----WQYVFHMLIAADII 540
Cdd:TIGR00894 424 sknvWLIVFLIMAFVNIL 441
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
368-549 |
3.58e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.50 E-value: 3.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 368 FSLCLFFTKLVSYTFMYWLPLYIQKsstLG--PELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGML-FVASPIL 444
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES---LGasVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLlLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 445 LMY-QQYGALsmtisIVLLIVVGIFVngpyALITTSVSAELGQHSSLEGNANALATVTAIIdgtgSIGAAVGPLLAGLIS 523
Cdd:cd17325 78 FAFaTSYWQL-----LLARFLQGLAS----AAVWPAAMALIADIAPPEERGRAMGIFSSAI----GLGFLIGPLLGGLLA 144
|
170 180
....*....|....*....|....*..
gi 24656861 524 TA-GWQYVFHMLIAADIIAMVLLGRLV 549
Cdd:cd17325 145 DAlGYRAPFLVCAALALLALVLALLLL 171
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
368-549 |
4.11e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.20 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 368 FSLCLFFTKLVSYTFMYWLPLyIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMY 447
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 448 QqygALSMTISIVLLIVVGIFVNGPYALITTSVSAELGqhsslegnANALATVTAIIDGTGSIGAAVGPLLAGLISTA-G 526
Cdd:COG2814 94 L---APSLWLLLAARFLQGLGAGALFPAALALIADLVP--------PERRGRALGLLGAGLGLGPALGPLLGGLLADLfG 162
|
170 180
....*....|....*....|...
gi 24656861 527 WQYVFHMLIAADIIAMVLLGRLV 549
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
140-283 |
4.46e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.15 E-value: 4.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 140 TLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGV 219
Cdd:cd06173 244 AGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS-----PSLWLLLAALFLLGLAGGLFNVPL 318
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24656861 220 VALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPGIIIAAVGFLLFLF 283
Cdd:cd06173 319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAlGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
139-284 |
4.47e-06 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 49.12 E-value: 4.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 139 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGV-FTYMfgiartSNIHSLWYFIIVQIFAGIFQTTGWP 217
Cdd:cd17335 232 KTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVrWLLY------SFLENPWLVLPIELLHGLTFALVWA 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24656861 218 GVVALVGRWFGKSKRGLIFGIWNS-HTSIGNILGTLIAAHYVES-DWALSFVVPGiIIAAVGFLLFLFL 284
Cdd:cd17335 306 AAVSYASAAAPPGLRATAQGLLQGlYFGLGGGLGSLIGGYLYEAfGARTTFRFFA-IAALAGLLAFFLI 373
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
149-549 |
4.67e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.15 E-value: 4.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 149 FLFSYAIAMFA----SGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVALVG 224
Cdd:cd17329 40 VLALSAVAGIVasliGGRLADRFGRKPVMLAGLLLRALGFALLGFA-----HSPWLFAIALVLTGFGGGLFEPASEAMIA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 225 RWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFvvpgiIIAAVGFLLFLFLVDQpeivgcypqagqherrv 304
Cdd:cd17329 115 DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLF-----LAAAVLFLLAALVLLF----------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 305 anesdveqddeeQVRHNdaeinyrsaptertpILPRSQPEAVPRGRGRPISLIDALFipgvVEFSLCLFFTKLVSYTFMY 384
Cdd:cd17329 173 ------------LLPET---------------RPKRRAAEKTEILRGYKIVLRDRAF----LLFLLASFLISLIYFQLES 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 385 WLPLYIQKSSTLGPelsADLSTLFDVGGILgaiaagylsdvsgmsatVCTGMLFVA------SPILLMYqqYGALSMTIS 458
Cdd:cd17329 222 TLPVYVVEILGLGE---SLLGLLLALNALL-----------------IVLLQFPVArlverfRLRKILM--IGILLFAIG 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 459 IVLLivvgIFVNGPYALITTSVSAELGQ-----HSSLEGNANA----LATVTAIIDGTGSIGAAVGPLLAG-LISTAGWQ 528
Cdd:cd17329 280 FAVL----AFANTLAVLILAMIVLTLGEmlvfpAVQTLVAALAppdkRGSYMGFYALAWGLGRAIGPLVGGlLLDLLGPG 355
|
410 420
....*....|....*....|.
gi 24656861 529 YVFHMLIAADIIAMVLLGRLV 549
Cdd:cd17329 356 LPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
353-544 |
5.55e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 48.71 E-value: 5.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 353 PISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYL-SDVSGMSAT 431
Cdd:cd17502 157 PIGGLALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALiSKTGRYKPL 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 432 VCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSslegnanaLATVTAIIDGTGSIG 511
Cdd:cd17502 237 IVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPAD--------VGVATATNTFFRSLG 308
|
170 180 190
....*....|....*....|....*....|...
gi 24656861 512 AAVGpllaglISTagwQYVFHMLIAADIIAMVL 544
Cdd:cd17502 309 GTLG------VAI---TDVFLVALALAALAFLL 332
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
394-549 |
6.38e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 48.72 E-value: 6.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 394 STLGPELSADLS----------TLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQqygALSMTISIVLLI 463
Cdd:COG2223 25 SVLAPPLAEEFGlsaaqlgllfAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLAL---AVSYWLLLLLGL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 464 VVGIFVNGPYALITTSVSAELGQHSslegnanaLATVTAIIDGTGSIGAAVGPLLAG-LISTAGWQYVFHMLIAADIIAM 542
Cdd:COG2223 102 LLGIGGGGSFAVGIALVSKWFPPDR--------RGLALGLAAGGGNLGAAVAAFLAPlLIAAFGWRNAFLILGILLLVVA 173
|
....*..
gi 24656861 543 VLLGRLV 549
Cdd:COG2223 174 VLAWLFL 180
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
133-548 |
6.68e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 6.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 133 FDVPDATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQ 212
Cdd:cd06173 27 LQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIAS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 213 TTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVesdwALSFVVPGIIIAAVGFLLFLFLVdqpeivg 292
Cdd:cd06173 107 AFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV----ALLGPGGAFAINALSFLLSALLL------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 293 CYPQAGQHERRVANESDVEQDDEEQVRHndaeinYRSAPTERTPILprsqpeavprgrgrpislidalfipgvvefSLCL 372
Cdd:cd06173 176 LFIRRPPPAAPGESSSLLLRDLREGLRY------LRRSPLLRLLLL------------------------------ALAL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 373 FFTKLVSYTFMywLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGA 452
Cdd:cd06173 220 FALLGGALTVL--LPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 453 LSMTISIVLLIVVGIFVNGP-YALITTSVSAELgqhsslegnanaLATVTAIIDGTGSIGAAVGPLLAGLISTA-GWQYV 530
Cdd:cd06173 298 WLLLAALFLLGLAGGLFNVPlNTLLQLRVPDEL------------RGRVFSVYNALNSGAMPLGALLAGLLADAlGLSAV 365
|
410
....*....|....*...
gi 24656861 531 FhMLIAADIIAMVLLGRL 548
Cdd:cd06173 366 F-LLAGALLLLAALLLLL 382
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
135-544 |
7.22e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 48.34 E-value: 7.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 135 VPDATTLFGMLDSafLFSYAIAMFA--SGFVAERVSLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQ 212
Cdd:cd17473 30 VPNSELLVPLLLT--LPALFIALFAplAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLD-----SLYALLASRALLGIGV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 213 TTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGI-IIAAVGFLLFLFlvdqpeiv 291
Cdd:cd17473 103 AGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLaLPVLILVLLFLP-------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 292 gcypqagqherrvanesdveqdDEEQVRHNDAeinyRSAPTERTPILPRSqpeavprgrgrpislidalfipgVVEFSLC 371
Cdd:cd17473 175 ----------------------EPARKSKSAA----SPGAATAAALPWKR-----------------------VLPIYFL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 372 LFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYG 451
Cdd:cd17473 206 AFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASG 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 452 alsmtisiVLLIVVGIFVNG-PYALITTSVSAELGQHSSLEGNANALATVTAIIdgtgSIGAAVGPLLAGLISTAGWQYV 530
Cdd:cd17473 286 --------LWVVLLGAILAGlGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAF----FLGQFLSPLVLGPLVNLTGGLS 353
|
410
....*....|....
gi 24656861 531 FHMLIAAdIIAMVL 544
Cdd:cd17473 354 GAFLILG-VLALVL 366
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
143-544 |
8.33e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.36 E-value: 8.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVAL 222
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA-----TSVALLLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 223 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVEsdwALSFVVPGIIIAAVGFLLFLFLvdqpeivgcypqagqher 302
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ---HLGFAVLFIVAAVLALLALLLV------------------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 303 rvanesdveqddeeqvrhndaeinyrsAPTERTPILPRSQPEAVPRGRGRpislidaLFIPGVVEFSLCLFFTKLVSYTF 382
Cdd:cd17489 168 ---------------------------FLVKDPPPVAAEEAEAGTRAFRR-------LVEKKVLPPALILFLASIAYGAI 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 383 MYWLPLYIQkssTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLmyqqygaLSMTISIVLL 462
Cdd:cd17489 214 STFLPLYAA---ERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLL-------LSFAGSPWML 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 463 IVVGIFVNGPYALITTSVSAELGQHSSLEGNANALATVTAIIDgtgsIGAAVGPLLAGLISTA-GWQYVFHMLIAADIIA 541
Cdd:cd17489 284 LLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFD----LGIGLGGLLLGLVAELfGYRAMFLLAAVVVLLA 359
|
...
gi 24656861 542 MVL 544
Cdd:cd17489 360 LVL 362
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
139-545 |
1.30e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 139 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPG 218
Cdd:cd17477 30 TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT-----DSPWVWFLLRFVMGIGLAGLFVV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 219 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALsFVVPGIIIAAVGFLLFLFLVDQPEIvgcypqag 298
Cdd:cd17477 105 SESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALP-FLIAAVLLLLALVPLLLTRRAAPEI-------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 299 qherrvanesdveqddeEQVRHNDAEINYRSAPTertpilprsqpeavprgrgrpisLIDALFIPGVVEFSLclfftklv 378
Cdd:cd17477 176 -----------------EEAESISLRRLLRIAPL-----------------------ALLGAFVAGFLEGAF-------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 379 sYTFMywlPLYIQkSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSG--MSATVCTGMLFVASPILLMYQQYGALSMt 456
Cdd:cd17477 208 -YSLL---PLYGL-RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDrrRVLLGCALLGALAALLLPLVPGLPLALL- 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 457 isiVLLIVVGIFVNGPYALittsVSAELGQHssLEGnaNALATVTAIIDGTGSIGAAVGPLLAGLISTAGWQYVFHMLIA 536
Cdd:cd17477 282 ---VLLFLWGGAAGPLYTL----ALALAGDR--LPG--DELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLA 350
|
....*....
gi 24656861 537 ADIIAMVLL 545
Cdd:cd17477 351 AVALLFLLF 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
138-283 |
2.89e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 46.65 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 138 ATTLFGMLDSAFLFSYAIAMFASGFVAERV-SLRYFLSMGMILTGVFTYMFGIARtsnihSLWYFIIVQIFAGIFQTTGW 216
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAP-----SLLLLLLLLLLLGFGLGGLL 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24656861 217 PGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLF 283
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
373-565 |
5.22e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.68 E-value: 5.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 373 FFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMyqqyGA 452
Cdd:cd17329 9 FLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL----GF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 453 LSMTISIVLLIVVGIFVNGpyaLITTSVSAELGQHSSLEGNANALATVTAIIdgtgSIGAAVGPLLAGLISTAGWQYVFH 532
Cdd:cd17329 85 AHSPWLFAIALVLTGFGGG---LFEPASEAMIADVTTPENRTRAFSLLYWAI----NLGVAIGPLLGGLLLLYSFRLLFL 157
|
170 180 190
....*....|....*....|....*....|...
gi 24656861 533 MLIAADIIAMVLLGRLvFKEFAALRRASHRIRI 565
Cdd:cd17329 158 AAAVLFLLAALVLLFL-LPETRPKRRAAEKTEI 189
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
118-529 |
6.00e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 45.64 E-value: 6.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 118 STALAASGQDCGYAPFDVPDATTlfgmldsAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsniHS 197
Cdd:cd17503 16 NVALPTIMGDLGASLDTVQWVIT-------SYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA-----PN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 198 LWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES-DWALSFVVPgIIIAAV 276
Cdd:cd17503 84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNlSWRWIFYIN-LPIGIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 277 GFLLflflvdqpeivgcypqagqherrvanesdveqddeeqvrhndaeinyrsapterTPILPrsqpeavprgrgrpisl 356
Cdd:cd17503 163 ALLL------------------------------------------------------APLLD----------------- 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 357 IDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGM 436
Cdd:cd17503 172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 437 LFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSleGNANALATVTAIIdgTGSIGAAVgp 516
Cdd:cd17503 252 LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQI--GDATALFNTIRQL--GGSIGTAL-- 325
|
410
....*....|...
gi 24656861 517 lLAGLISTAGWQY 529
Cdd:cd17503 326 -LATLLTNRTQFH 337
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
147-283 |
9.62e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.90 E-value: 9.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 147 SAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGifqTTGWPGVVALVGRW 226
Cdd:cd17316 220 LLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFV---GGVWGALYAYLAEL 296
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 24656861 227 FGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLF 283
Cdd:cd17316 297 FPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
149-285 |
1.71e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.12 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 149 FLFSYAIAMFASGFVAERVSLRY----FLSMGMILTGVFTYMFGIArtsniHSLWYFIIVQIFAGIFQTTGWPGVVALVG 224
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKLSDRKgpktVIIPGLLLLALGLLLLSFA-----GSPWMLLLAAVLYGLGFGLLFPALQALAV 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24656861 225 RWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESdwaLSFVVP---GIIIAAVGFLLFLFLV 285
Cdd:cd17489 307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL---FGYRAMfllAAVVVLLALVLYIFLL 367
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
143-289 |
1.93e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.10 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtsnIHSLWYFIIVQIFAGIFQTTGWPGVVAL 222
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA----LGSLWLFLVLFLLLGLALGGGNGAVFAL 319
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24656861 223 VGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES--DWALSFVVpGIIIAAVGFLLFLFLVDQPE 289
Cdd:COG2223 320 VPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLV-FAVLALVALVLTLLLYRRPR 387
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
148-545 |
2.51e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 2.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 148 AFLFSYAIAMFaSGFVAERVSLRY-FLSMGMILTGVFTYMFGIARTSnIHSLWYFIIVQIFAGIFQttgwPGVVALVGRW 226
Cdd:cd17370 43 AEALGSLLRLF-SGYLSDRTGKRKpLVILGYGLSALAKPLLALAGSW-QLVLLLRILERLGKGIRT----PPRDALLADA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 227 FGKSKRGLIFGIWNSHTSIGNILGTLIAA---HYVESDWALSFVVpGIIIAAVGFLLFLFLVDQPEivgcypqagqherr 303
Cdd:cd17370 117 TPPSGRGKAFGLHRALDTLGAVLGPLLAAlllYLLGGNYRTIFLL-AAIPALLALLILLFVVKEYP-------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 304 vanesdveqddeeqvrhndaeinyrsapteRTPILPRSQPEavPRGRGRPISLIDALFIPGVVEFSLclfftklVSYTFM 383
Cdd:cd17370 182 ------------------------------RPPKLRKKSKK--TSLKKLPKAFWLYLLAVALFALGN-------FSFAFL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 384 ywlpLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGML-FVASPILLMyqqyGALSMTISIVLL 462
Cdd:cd17370 223 ----ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLsLALAYLGFA----LGSSLWLLLLGF 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 463 IVVGIFvngpYALITTSVSAELGQHSSLEGNANALATVTAIIdgtgSIGAAVGPLLAG-LISTAGWQYVFHMLIAADIIA 541
Cdd:cd17370 295 ILWGLY----MGAQESIERAAVADLVPAELRGTAYGLFNTVV----GIGWLLASLIAGyLWDLISPSAAFLFSAVLALIA 366
|
....
gi 24656861 542 MVLL 545
Cdd:cd17370 367 LLLL 370
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
149-283 |
2.85e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.34 E-value: 2.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 149 FLFSYAIAMFASGFVAeRVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFG 228
Cdd:cd17330 216 LALVGIAGILAQLLLI-PRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVP 294
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 24656861 229 KSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLF 283
Cdd:cd17330 295 SKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
390-564 |
2.88e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.88 E-value: 2.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 390 IQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGM-LFVASPILLMYqqygALSMTISIVLLIVVGIF 468
Cdd:COG0477 40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLlLFGLASLLCGL----APSPELLIAARALQGIG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 469 VngpyALITTSVSAELGQHSslegNANALATVTAIIDGTGSIGAAVGPLLAG-LISTAGWQYVFhmLIAADIIAMVLLGR 547
Cdd:COG0477 116 A----GGLMPGALALIAELF----PARERGRALGLWGAAIGLGLALGPLLGGlLVAALGWRWIF--LINAPLGLLALVLR 185
|
170
....*....|....*..
gi 24656861 548 LVFKEFAALRRASHRIR 564
Cdd:COG0477 186 LRLPESRGLLLALLALA 202
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
175-283 |
7.49e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 42.18 E-value: 7.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 175 MGMILTG----VFTYMFGIARTSNIHSLWYFIivqiFAGIFQTTG----WPGVVALVGRWFGKSKRGLIFGIWNSHTSIG 246
Cdd:cd17346 276 LGLLLLGlsflLMVLAASFAGGSGKVSALWLV----LSYFLQTLGelclSPVGLSMITKLAPAKFAGFMMGLWFLASALG 351
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 24656861 247 NILGTLIAAHYVESDWALS--------FVVPGIIIAAVGFLLFLF 283
Cdd:cd17346 352 NILAGYLAGFYAQPKDPLAsalvytdyFGLIGVIALVAGIILLLL 396
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
360-548 |
7.69e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.77 E-value: 7.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 360 LFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIqKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSAT----VCTG 435
Cdd:cd17352 180 LKDPTFVLLALGVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLylyiFTLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 436 MLFVASPILLMYQQYGALsmtisIVLLIVVGIFVNGPYALIttsvSAELGQHSSLEGNANALATVTAIidgtGSIGAAVG 515
Cdd:cd17352 259 ILGLSLLAFPLATTYVGL-----IVFSVLFGFCSGSYSSLT----PVILADLVGLEKLSNAYGLVLLF----QGLAALVG 325
|
170 180 190
....*....|....*....|....*....|....*
gi 24656861 516 PLLAGLI--STAGWQYVFHMLIAADIIAMVLLGRL 548
Cdd:cd17352 326 PPIAGLLrdYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
147-281 |
9.89e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 41.98 E-value: 9.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 147 SAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIArtSNIHSLWYFIIVQ-IFAGIFQttgwPGVVALVGR 225
Cdd:TIGR00711 44 TSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVA--PNLELMIIFRVIQgFGGGPLI----PLSFSTLLN 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24656861 226 WFGKSKRGLIFGIWNSHTSI----GNILGTLIAAHYvesDWALSF---VVPGIIIAAVGFLLF 281
Cdd:TIGR00711 118 IYPPEKRGRAMAIWGLTVLVapalGPTLGGWIIENY---HWRWIFlinVPIGIIVVVVAFFIL 177
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
353-525 |
1.06e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.41 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 353 PISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTL----FDVGGILGAIAAGYLSDVSGM 428
Cdd:cd17504 167 PLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLlllpGALVMLIAGPLAGRLIARVGP 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 429 SATVCTGMLFVASPILLMYqqYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGqhsslegnANALATVTAIIDGTG 508
Cdd:cd17504 247 RRVLLIGLVISAVGLLLLA--LLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVP--------PDRTGIATGMNTVLR 316
|
170
....*....|....*..
gi 24656861 509 SIGAAVGPLLAGLISTA 525
Cdd:cd17504 317 TIGSAIGPAIAGAILTT 333
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
143-283 |
1.16e-03 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 41.30 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 143 GMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHslwYFIIVQIFAGIFQTTGWPGVVAL 222
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAG---YLIAVRALEGLGEGVTFPAMHAM 144
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24656861 223 VGRWFGKSKRGLIFGIwnshTSIGNILGTLIA-------AHYVesDWALSFVVPGiiiaAVGFLLFLF 283
Cdd:cd17381 145 WASWAPPLERSRLLTI----SYAGAQLGTVVSlplsgliCYYL--DWTYVFYIFG----AVGLLWFFL 202
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
404-564 |
1.22e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.40 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 404 LSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTISIVLlIVVGIFVNgpYALITTSVSAE 483
Cdd:COG2807 58 LTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL-IGAGIAVG--NVLLPGLIKRW 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 484 LGQHSSLegnanalatVTAIIDGTGSIGAAVGPLLAG-LISTAGWQYVFHMLIAADIIAMVLLGRLVFKEFAALRRASHR 562
Cdd:COG2807 135 FPDRVGL---------MTGLYTAAMGLGAALAAGLTVpLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA 205
|
..
gi 24656861 563 IR 564
Cdd:COG2807 206 AS 207
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
389-561 |
3.03e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.10 E-value: 3.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 389 YIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMyqqYGALSMTISIVLLIVVGIF 468
Cdd:cd06174 21 ALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF---AFAPSFWLLLLGRFLLGLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 469 vngpYALITTSVSAELGQHSslegNANALATVTAIIDGTGSIGAAVGPLLAGLI---STAGWQYVFhMLIAADIIAMVLL 545
Cdd:cd06174 98 ----SGLIDPAVLALIADLF----PERERGRALGLLQAFGSVGGILGPLLGGILassLGFGWRAVF-LIAAALALLAAIL 168
|
170
....*....|....*.
gi 24656861 546 GRLVFKEFAALRRASH 561
Cdd:cd06174 169 LLLVVPDPPESARAKN 184
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
149-283 |
3.39e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.92 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 149 FLFSYAIAMFA--SGFVAERVSLRyflsmGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIF----QTTGWPgVVAL 222
Cdd:cd17313 288 LIFSLAFLIFSlpIGKLGKKIGRK-----KVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGwatiNINPYP-LVSD 361
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24656861 223 VGRWFGKSKrGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLF 283
Cdd:cd17313 362 YHSESGRGQ-GTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
139-283 |
4.09e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 39.91 E-value: 4.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 139 TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIartsnIHslwYFIIVQIFAGIFQTTGWPG 218
Cdd:cd17336 37 SSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFLLAL-----PH---FLFVGQFLLGIGSSPLYTL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 219 VVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAH----YVESD----------------WALSFVVPGIIIAAVGF 278
Cdd:cd17336 109 GITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFllriYVDFSrvplgitpddprwigaWWLGFLILGILLLIVSI 188
|
....*
gi 24656861 279 LLFLF 283
Cdd:cd17336 189 PLFFF 193
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
389-555 |
4.66e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 4.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 389 YIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQqygALSMTISIVLLIVVGIF 468
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL---APSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 469 VngpyALITTSVSAELGQHSSLEGnanalATVTAIIDGTGSIGAAVGPLLAGLISTAG----WQYVFHMLIAADIIAMVL 544
Cdd:COG0738 110 L----GLLDVAANPYVAALGPETA-----ASRLNLLHAFFSLGALLGPLLGGLLILLGlslsWHLPYLILAVLLLLLALL 180
|
170
....*....|.
gi 24656861 545 LGRLVFKEFAA 555
Cdd:COG0738 181 FLRSKLPEIEE 191
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
397-545 |
8.16e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 8.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24656861 397 GPELSADLSTLFDVGGILGAIAAGYLSDVSG-MSATVCTGMLFVASPILLMyqqyGALSMTISIVLLIVVGIfvNGPYAL 475
Cdd:cd06179 30 PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGrRWFFIGGNLLGVVGSIVAG----TAKSVNMLIGGQALIGI--GAGTQG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24656861 476 ITTSVSAEL--GQHSSLegnANALATVTAiidgtgSIGAAVGPLLAGLI---STAGWQYVFHMLIAADIIAMVLL 545
Cdd:cd06179 104 LGAAVASELvpNKYRGL---VQGVVNLVA------SPGSALGPLIAGALveaNAAGWRWIFYINAIFNALALILL 169
|
|
| |
