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Conserved domains on  [gi|24418880|ref|NP_722472|]
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leucine-rich repeat-containing protein 56 isoform a [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-196 1.86e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 1.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880  83 NSLGNfglyLPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQL 162
Cdd:COG4886 199 EPLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNL 274

                        90       100       110
                ....*....|....*....|....*....|....
gi 24418880 163 EVLDLEGNNVEDLgQMRYLQLCPRLAMLTLEGNL 196
Cdd:COG4886 275 KTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-196 1.86e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 1.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880  83 NSLGNfglyLPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQL 162
Cdd:COG4886 199 EPLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNL 274

                        90       100       110
                ....*....|....*....|....*....|....
gi 24418880 163 EVLDLEGNNVEDLgQMRYLQLCPRLAMLTLEGNL 196
Cdd:COG4886 275 KTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 92-233 1.57e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 1.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880  92 LPNLIQLKLNHSYLGSLRDLGtSLGHLQVLWLAR------CGLTDLDgigsflELKELYVSY------------------ 147
Cdd:cd21340  45 LTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGGnrisvvEGLENLT------NLEELHIENqrlppgekltfdprslaa 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880 148 ------------NNISDLSPLCLLEQLEVLDLEGNNVEDLGQM-RYLQLCPRLAMLTLEGNLVCLKPdpgpsnkapqgyN 214
Cdd:cd21340 118 lsnslrvlnisgNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKP------------K 185

                       170
                ....*....|....*....
gi 24418880 215 YRAEVKKLIPQLHVLDEVP 233
Cdd:cd21340 186 YRDKIILASKSLEVLDGKE 204
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 140-171 3.43e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 44.16  E-value: 3.43e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 24418880   140 LKELYVSYNNISDLSPLCLLEQLEVLDLEGNN 171
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-196 1.86e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 1.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880  83 NSLGNfglyLPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQL 162
Cdd:COG4886 199 EPLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNL 274

                        90       100       110
                ....*....|....*....|....*....|....
gi 24418880 163 EVLDLEGNNVEDLgQMRYLQLCPRLAMLTLEGNL 196
Cdd:COG4886 275 KTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-195 5.01e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 5.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880  84 SLGNFGLYLPNLIQLKLNHSylgSLRDLGTSLGH---LQVLWLARCGLTDL-DGIGSFLELKELYVSYNNISDLSPLCLL 159
Cdd:COG4886 173 DLPEELGNLTNLKELDLSNN---QITDLPEPLGNltnLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNL 249

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 24418880 160 EQLEVLDLEGNNVEDLGQMRYLQlcpRLAMLTLEGN 195
Cdd:COG4886 250 TNLEELDLSNNQLTDLPPLANLT---NLKTLDLSNN 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-195 5.58e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 5.58e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880  92 LPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDL-DGIGSFLELKELYVSYNNISDLS-PLCLLEQLEVLDLEG 169
Cdd:COG4886 135 LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSG 214

                        90       100
                ....*....|....*....|....*.
gi 24418880 170 NNVEDLGQmrYLQLCPRLAMLTLEGN 195
Cdd:COG4886 215 NQLTDLPE--PLANLTNLETLDLSNN 238
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 92-233 1.57e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 1.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880  92 LPNLIQLKLNHSYLGSLRDLGtSLGHLQVLWLAR------CGLTDLDgigsflELKELYVSY------------------ 147
Cdd:cd21340  45 LTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGGnrisvvEGLENLT------NLEELHIENqrlppgekltfdprslaa 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880 148 ------------NNISDLSPLCLLEQLEVLDLEGNNVEDLGQM-RYLQLCPRLAMLTLEGNLVCLKPdpgpsnkapqgyN 214
Cdd:cd21340 118 lsnslrvlnisgNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKP------------K 185

                       170
                ....*....|....*....
gi 24418880 215 YRAEVKKLIPQLHVLDEVP 233
Cdd:cd21340 186 YRDKIILASKSLEVLDGKE 204
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-195 1.63e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 1.63e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880  66 DDLQLVRVLEMCVDTRKNSLGNFGLYLPNLIQLK-LNHSYLGSLRDLGtSLGHLQVLWLARCGLTDL-DGIGSFLELKEL 143
Cdd:COG4886  63 SSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTnLTELDLSGNEELS-NLTNLESLDLSGNQLTDLpEELANLTNLKEL 141

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24418880 144 YVSYNNISDL-SPLCLLEQLEVLDLEGNNVEDLGQMryLQLCPRLAMLTLEGN 195
Cdd:COG4886 142 DLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNN 192
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 140-171 3.43e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 44.16  E-value: 3.43e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 24418880   140 LKELYVSYNNISDLSPLCLLEQLEVLDLEGNN 171
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-187 6.20e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 6.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880  92 LPNLIQLKLNHSYLGSLRDLGtSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSplclLEQLEVLDLEGNN 171
Cdd:COG4886 227 LTNLETLDLSNNQLTDLPELG-NLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK----LKELELLLGLNSL 301

                        90
                ....*....|....*.
gi 24418880 172 VEDLGQMRYLQLCPRL 187
Cdd:COG4886 302 LLLLLLLNLLELLILL 317
LRR_8 pfam13855
Leucine rich repeat;
117-172 1.11e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.11e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24418880   117 HLQVLWLARCGLTDLDGiGSFL---ELKELYVSYNNISDLSPLCL--LEQLEVLDLEGNNV 172
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKglsNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 117-156 2.62e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.46  E-value: 2.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 24418880   117 HLQVLWLARCGLTDLDGIGSFLELKELYVSYNN-ISDLSPL 156
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDL 42
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 98-182 1.37e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24418880  98 LKLNHSYLGSLRDLGtSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQLEVLDLEGNN---VED 174
Cdd:cd21340   7 LYLNDKNITKIDNLS-LCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRisvVEG 85


                ....*...
gi 24418880 175 LGQMRYLQ 182
Cdd:cd21340  86 LENLTNLE 93
LRR_8 pfam13855
Leucine rich repeat;
139-197 2.36e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.36e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24418880   139 ELKELYVSYNNISDLSPLCL--LEQLEVLDLEGNNVEDLGqMRYLQLCPRLAMLTLEGNLV 197
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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