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Conserved domains on  [gi|386768359|ref|NP_722455|]
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tapas, isoform F [Drosophila melanogaster]

Protein Classification

tudor domain-containing protein( domain architecture ID 11886536)

tudor domain-containing protein adopts a beta-barrel-like structure and may bind to proteins with dimethylated arginine or lysine residues, or to methylated histone tails to facilitate protein-protein interactions; similar to Caenorhabditis elegans protein tag-250

CATH:  2.30.30.140
Gene Ontology:  GO:0005515
PubMed:  24035451|22669818|20728048
SCOP:  4003195

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TUDOR pfam00567
Tudor domain;
948-1065 3.32e-15

Tudor domain;


:

Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 72.77  E-value: 3.32e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359   948 AYFEVRVALSVNPGHFAVQPYKYYNQLQTLMKNLQEHCQKTAAKGVQPsqlAIGEAYAAPDSE-GVYHRVSIHK-IYDEI 1025
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPP---AVGDGCVAAFSEdGKWYRAKITEsLDDGL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 386768359  1026 IHVRFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQLYG 1065
Cdd:pfam00567   78 VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR super family cl26991
Tudor domain;
477-587 1.20e-11

Tudor domain;


The actual alignment was detected with superfamily member pfam00567:

Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 62.76  E-value: 1.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359   477 FISFCDSTKIVWARMIDQIANFEELTKHIGRQMESPHFRQKVSKPYAQEVYLVEMPDGWNRVRaisVDEETRSGRYH--F 554
Cdd:pfam00567    6 VVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAK---ITESLDDGLVEvlF 82

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 386768359   555 IDFGDVAMFHSEDLFHCPPQFLALPAQA--VCLSM 587
Cdd:pfam00567   83 IDYGNTETVPLSDLRPLPPELESLPPQAikCQLAG 117
TUDOR super family cl26991
Tudor domain;
683-810 9.87e-06

Tudor domain;


The actual alignment was detected with superfamily member pfam00567:

Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 45.81  E-value: 9.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359   683 KTTPILVSHINDDGDLMVLLrnddlKFVERSIAQTVADLGEQDRVSYSDLLHDRHIF--VCDETVDGvkQWFRGRLVtrp 760
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQP-----KSDSKKLEKLTEELQEYYASKPPESLPPAVGDgcVAAFSEDG--KWYRAKIT--- 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 386768359   761 LNPDEESFDVYYVDDGRQRKAHISNIYRLeanNRALATFPPQAIPVRLHD 810
Cdd:pfam00567   71 ESLDDGLVEVLFIDYGNTETVPLSDLRPL---PPELESLPPQAIKCQLAG 117
 
Name Accession Description Interval E-value
TUDOR pfam00567
Tudor domain;
948-1065 3.32e-15

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 72.77  E-value: 3.32e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359   948 AYFEVRVALSVNPGHFAVQPYKYYNQLQTLMKNLQEHCQKTAAKGVQPsqlAIGEAYAAPDSE-GVYHRVSIHK-IYDEI 1025
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPP---AVGDGCVAAFSEdGKWYRAKITEsLDDGL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 386768359  1026 IHVRFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQLYG 1065
Cdd:pfam00567   78 VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
477-587 1.20e-11

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 62.76  E-value: 1.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359   477 FISFCDSTKIVWARMIDQIANFEELTKHIGRQMESPHFRQKVSKPYAQEVYLVEMPDGWNRVRaisVDEETRSGRYH--F 554
Cdd:pfam00567    6 VVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAK---ITESLDDGLVEvlF 82

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 386768359   555 IDFGDVAMFHSEDLFHCPPQFLALPAQA--VCLSM 587
Cdd:pfam00567   83 IDYGNTETVPLSDLRPLPPELESLPPQAikCQLAG 117
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 954-1076 2.07e-10

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 59.80  E-value: 2.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  954 VALSVNPGHFAVQPYKYYNQLQTLMKNLQEHCQKTAA-----KGVQPSQLAIGEAYaapdSEGVYHRVSIHKIYDEIIHV 1028
Cdd:cd20438    11 VEYVLNPSNFWIRTDEYNNEFQALMKNIADIYNLCGNdeellKKPEPGLLCCARYS----KDRHYYRAVITEVLDLKVSV 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 386768359 1029 RFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQLYGIQLTDVVWSKE 1076
Cdd:cd20438    87 YFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTKN 134
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 478-583 1.83e-06

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 48.40  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  478 ISFCDSTKIVWarmIDQIANFEELTKhigrQMESpHF-----RQKVSKPYAQEVYLVEMPDG-WNRVRAISVDEETRSG- 550
Cdd:cd20435    10 LEHRSSDGEVT---KSMSSTYLKLSM----KLNM-YYsdpsnRILHGKVKVGDLCAVEDENNlYHRVKVLEITEKDDKTk 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 386768359  551 ----RYHFIDFGDVAMFHSEDLFHCPPQFLALPAQAV 583
Cdd:cd20435    82 prevLVKFIDEGRVETVVVSQLLELPEELKSLPPQAV 118
TUDOR pfam00567
Tudor domain;
683-810 9.87e-06

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 45.81  E-value: 9.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359   683 KTTPILVSHINDDGDLMVLLrnddlKFVERSIAQTVADLGEQDRVSYSDLLHDRHIF--VCDETVDGvkQWFRGRLVtrp 760
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQP-----KSDSKKLEKLTEELQEYYASKPPESLPPAVGDgcVAAFSEDG--KWYRAKIT--- 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 386768359   761 LNPDEESFDVYYVDDGRQRKAHISNIYRLeanNRALATFPPQAIPVRLHD 810
Cdd:pfam00567   71 ESLDDGLVEVLFIDYGNTETVPLSDLRPL---PPELESLPPQAIKCQLAG 117
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 749-789 7.64e-03

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 35.57  E-value: 7.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 386768359  749 KQWFRGRlVTRPLNPDEesFDVYYVDDGRQRKAHISNIYRL 789
Cdd:cd20379    13 GKWYRAR-VLEVLSNDK--VEVFFVDYGNTETVPLSDLRPL 50
 
Name Accession Description Interval E-value
TUDOR pfam00567
Tudor domain;
948-1065 3.32e-15

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 72.77  E-value: 3.32e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359   948 AYFEVRVALSVNPGHFAVQPYKYYNQLQTLMKNLQEHCQKTAAKGVQPsqlAIGEAYAAPDSE-GVYHRVSIHK-IYDEI 1025
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPP---AVGDGCVAAFSEdGKWYRAKITEsLDDGL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 386768359  1026 IHVRFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQLYG 1065
Cdd:pfam00567   78 VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
477-587 1.20e-11

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 62.76  E-value: 1.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359   477 FISFCDSTKIVWARMIDQIANFEELTKHIGRQMESPHFRQKVSKPYAQEVYLVEMPDGWNRVRaisVDEETRSGRYH--F 554
Cdd:pfam00567    6 VVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAK---ITESLDDGLVEvlF 82

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 386768359   555 IDFGDVAMFHSEDLFHCPPQFLALPAQA--VCLSM 587
Cdd:pfam00567   83 IDYGNTETVPLSDLRPLPPELESLPPQAikCQLAG 117
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 954-1076 2.07e-10

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 59.80  E-value: 2.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  954 VALSVNPGHFAVQPYKYYNQLQTLMKNLQEHCQKTAA-----KGVQPSQLAIGEAYaapdSEGVYHRVSIHKIYDEIIHV 1028
Cdd:cd20438    11 VEYVLNPSNFWIRTDEYNNEFQALMKNIADIYNLCGNdeellKKPEPGLLCCARYS----KDRHYYRAVITEVLDLKVSV 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 386768359 1029 RFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQLYGIQLTDVVWSKE 1076
Cdd:cd20438    87 YFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTKN 134
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 959-1078 7.87e-09

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 55.07  E-value: 7.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  959 NPGHFAVQPYKYyNQLQTLMK---NLQEHCQKT-AAKGVQPsqlAIGEAYAAPDSE-GVYHRVSIHK--IYDEIIHVRFV 1031
Cdd:cd20408     8 NPGEFYIQIYTL-EVLESLVKltsQLKKTYASVnNHKEYIP---EVGEVCVAKYSEdQNWYRALVQTvdVQQKKAGVFYI 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 386768359 1032 DVGDDGVIACDQLKTLNPELRKLPKMALPAQLYGIQLTDVVWSKENC 1078
Cdd:cd20408    84 DYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 960-1084 2.35e-08

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 54.04  E-value: 2.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  960 PGHFAVQPYKyyNQLQTLMKNLQEHCQKTAAKGVQPSQLAIGEAYAAPDSE-GVYHRVSIHKIYDEIIHVRFVDVGDDGV 1038
Cdd:cd20426    11 PEYFWCQFAT--EKIQCLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYSEdNHWYRALVTKINDNLVSVRFVDYGNEED 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 386768359 1039 IACDQLKTLNPELRKLPKMALPAQLYGIQLTDVVWSKENCVRFREL 1084
Cdd:cd20426    89 VVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYFYEI 134
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 954-1063 7.23e-08

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 52.07  E-value: 7.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  954 VALSVNPGHFAVQPY--KYYNQLQTLMKNLQeHC---QKTAAKGVQP-SQLAIGEAYAAPDSEGV-YHRVSIHKIYDE-I 1025
Cdd:cd20419     2 VEYIESPSQFYVRFYskDTSEMLEDMMIEMR-RCysnEHVSERYVMPeAFIQPGQVCCVRIPEDVwWYRVIIHQVLNKqE 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 386768359 1026 IHVRFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQL 1063
Cdd:cd20419    81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 951-1063 1.78e-06

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 47.84  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  951 EVRVALSVNPGHFAVQPYKYYNQLQTLMKNLQEHCQKTAAKGVQPSQLaiGEAYAAPDSE-GVYHRVSI-HKIYDEIIHV 1028
Cdd:cd20425     3 EVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQL--GDLICAEYPEdGLWYRAVVkEKIPNNLVSV 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 386768359 1029 RFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQL 1063
Cdd:cd20425    81 QFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 478-583 1.83e-06

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 48.40  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  478 ISFCDSTKIVWarmIDQIANFEELTKhigrQMESpHF-----RQKVSKPYAQEVYLVEMPDG-WNRVRAISVDEETRSG- 550
Cdd:cd20435    10 LEHRSSDGEVT---KSMSSTYLKLSM----KLNM-YYsdpsnRILHGKVKVGDLCAVEDENNlYHRVKVLEITEKDDKTk 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 386768359  551 ----RYHFIDFGDVAMFHSEDLFHCPPQFLALPAQAV 583
Cdd:cd20435    82 prevLVKFIDEGRVETVVVSQLLELPEELKSLPPQAV 118
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 949-1082 2.17e-06

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 48.28  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  949 YFEVRVALSVNPGHFAVQPYKYYNQLQTLMKNLQE-HCQKTAAKGV----QPSQLAigeayAAPDSEGVYHRVSIHKIYD 1023
Cdd:cd20422     1 FYDAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAfYSQASKLDGVvlkpQPGQLC-----CAKWKEDRYYRAIVTAVKG 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 386768359 1024 EIIHVRFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQLYGIQLTDVVWSKENCVRFR 1082
Cdd:cd20422    76 KMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134
TUDOR pfam00567
Tudor domain;
683-810 9.87e-06

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 45.81  E-value: 9.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359   683 KTTPILVSHINDDGDLMVLLrnddlKFVERSIAQTVADLGEQDRVSYSDLLHDRHIF--VCDETVDGvkQWFRGRLVtrp 760
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQP-----KSDSKKLEKLTEELQEYYASKPPESLPPAVGDgcVAAFSEDG--KWYRAKIT--- 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 386768359   761 LNPDEESFDVYYVDDGRQRKAHISNIYRLeanNRALATFPPQAIPVRLHD 810
Cdd:pfam00567   71 ESLDDGLVEVLFIDYGNTETVPLSDLRPL---PPELESLPPQAIKCQLAG 117
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 946-1066 2.08e-05

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 45.17  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  946 VGAYFEVRVALSVNPGHFAVQPYKYYNQLQTLMKNLQEHcQKTAAKGVQPSQLAIGEAYAapdSEGVYHRVSIHKIYDEI 1025
Cdd:cd20439     8 PGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSY-YLIHNDPYKHGQIACVAKYS---KDGKWYRAAVLKQVSAK 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 386768359 1026 -IHVRFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQLYGI 1066
Cdd:cd20439    84 eVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 946-1063 2.15e-05

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 45.10  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  946 VGAYFEVRVALSVNPGHFAVQPYKYYNQLQTLMKNLQEHCQkTAAKGVQPSQLAIGEAYAAPDSEGVYHRVSIHKIY-DE 1024
Cdd:cd20437     1 VGTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYE-SVSKELNPSCENFGLLCAAKGKDGQWHRGFLQQLLpPS 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 386768359 1025 IIHVRFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQL 1063
Cdd:cd20437    80 QVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 1000-1047 2.94e-05

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 42.50  E-value: 2.94e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 386768359 1000 IGEAYAAPDSE-GVYHRVSIHKIY-DEIIHVRFVDVGDDGVIACDQLKTL 1047
Cdd:cd20379     1 VGDLCAAKYEEdGKWYRARVLEVLsNDKVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1010-1067 5.54e-05

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 42.47  E-value: 5.54e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359 1010 EGVYHRVSIHKIYD--EIIHVRFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQLYGIQ 1067
Cdd:cd20423    16 DGKWCRALIDNVYEpvEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLI 75
Tudor_TDRD7_rpt2 cd20428
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 507-586 1.35e-04

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410499  Cd Length: 140  Bit Score: 43.20  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  507 RQMESPHFrqkVSKPYAQEVYLVEMPDGWNRVRAISVdEETRSGRYHFIDFGDVAMFHSEDLFHCPPQFL----ALPAQA 582
Cdd:cd20428    41 RQMTSEYF---VSLPFCGKICLARYKGKWARVEITNV-HSSRALDVHFLDTGTVASVKVSELREIPPPFLreliSIPPQA 116


                  ....*.
gi 386768359  583 V--CLS 586
Cdd:cd20428   117 LkcCLA 122
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 996-1055 2.31e-04

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 42.24  E-value: 2.31e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386768359  996 SQLAIGEAYAAPDSEGVYHRVSIHKIYDE-------IIHVRFVDVGDDGVIACDQLKTLNPELRKLP 1055
Cdd:cd20435    48 GKVKVGDLCAVEDENNLYHRVKVLEITEKddktkprEVLVKFIDEGRVETVVVSQLLELPEELKSLP 114
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 967-1065 6.25e-04

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 40.87  E-value: 6.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768359  967 PYKYYNQLQTL---MKNLQEHC------QKTAAKGVQPSQLaiGEAYAAPDSEGVYHRVSIHKIY--DEIIHVRFVDVGD 1035
Cdd:cd20421    23 PHRIFCQLRSLsqeLKRLSESMhqyyegRVGSGYETRPEKL--GSPCAARGSDGRWYRAVLQQVFsaNRVVEVLHVDYGR 100

                          90       100       110
                  ....*....|....*....|....*....|
gi 386768359 1036 DGVIACDQLKTLNPELRKLPKMALPAQLYG 1065
Cdd:cd20421   101 KEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
 508-583 4.26e-03

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 37.66  E-value: 4.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386768359  508 QMESPHFRQKVSKPYAQEvylvempDGWNRVRAISVDEETRSGRYhFIDFGDVAMFHSEDLFHCPPQFLALPAQAV 583
Cdd:cd20412    25 TLLTVQVGDIVAAPFRHD-------GSWYRARVLGFLENGNLDLY-FVDYGDSGYVPLEDLRALRSDFLSLPFQAI 92
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 749-789 7.64e-03

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 35.57  E-value: 7.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 386768359  749 KQWFRGRlVTRPLNPDEesFDVYYVDDGRQRKAHISNIYRL 789
Cdd:cd20379    13 GKWYRAR-VLEVLSNDK--VEVFFVDYGNTETVPLSDLRPL 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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