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Conserved domains on  [gi|300797299|ref|NP_705933|]
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sodium/potassium/calcium exchanger 4 isoform 2 [Homo sapiens]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-587 3.45e-117

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 373.95  E-value: 3.45e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299    80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   237 LYVFYILIMKYN------VKMQAFFTVKQKSIANG------------------------------NPVNSELEAVKEKPQ 280
Cdd:TIGR00927  594 AYALYVFTMKWNkqielwVKEQLSRRPVAKVMALGdlskgdvaeaehtgertgeegerpteaegeNGEESGGEAEQEGET 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   281 YGKNPVVMVDEIMSS---------------------------SPPKFTFPE--------------------------AGL 307
Cdd:TIGR00927  674 ETKGENESEGEIPAErkgeqegegeieakeadhkgeteaeevEHEGETEAEgtedegeietgeegeevedegegeaeGKH 753

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   308 RIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVSSK----PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPP 382
Cdd:TIGR00927  754 EVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETG 833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   383 PEPEPV-----------------------------------------------EADFLSPFSV--PEARGDKVKWVFTWP 413
Cdd:TIGR00927  834 EQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYLFLLP 913

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   414 LIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQ 493
Cdd:TIGR00927  914 IVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARK 993

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   494 GLGDMAVSNTIGSNVFDILVGLGVPWGLQTMvVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVL 573
Cdd:TIGR00927  994 GLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMF 1072

                          650
                   ....*....|....
gi 300797299   574 VLYAIFLCFSIMIE 587
Cdd:TIGR00927 1073 LLYFVFLIISVMLE 1086
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-587 3.45e-117

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 373.95  E-value: 3.45e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299    80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   237 LYVFYILIMKYN------VKMQAFFTVKQKSIANG------------------------------NPVNSELEAVKEKPQ 280
Cdd:TIGR00927  594 AYALYVFTMKWNkqielwVKEQLSRRPVAKVMALGdlskgdvaeaehtgertgeegerpteaegeNGEESGGEAEQEGET 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   281 YGKNPVVMVDEIMSS---------------------------SPPKFTFPE--------------------------AGL 307
Cdd:TIGR00927  674 ETKGENESEGEIPAErkgeqegegeieakeadhkgeteaeevEHEGETEAEgtedegeietgeegeevedegegeaeGKH 753

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   308 RIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVSSK----PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPP 382
Cdd:TIGR00927  754 EVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETG 833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   383 PEPEPV-----------------------------------------------EADFLSPFSV--PEARGDKVKWVFTWP 413
Cdd:TIGR00927  834 EQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYLFLLP 913

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   414 LIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQ 493
Cdd:TIGR00927  914 IVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARK 993

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   494 GLGDMAVSNTIGSNVFDILVGLGVPWGLQTMvVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVL 573
Cdd:TIGR00927  994 GLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMF 1072

                          650
                   ....*....|....
gi 300797299   574 VLYAIFLCFSIMIE 587
Cdd:TIGR00927 1073 LLYFVFLIISVMLE 1086
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
120-582 1.49e-36

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 137.96  E-value: 1.49e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 120 DFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVRLT 199
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 200 WWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKmqafftvkqksiaNGNPVNSELEAVKEKP 279
Cdd:COG0530   80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRAR-------------KEPAWEEVEEELEEKP 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 280 QYgknpvvmvdeimsssppkftfpeaglrimitnkfgprtrlrmasriiinerqrlinsangvsskplqngrheniengn 359
Cdd:COG0530  147 KM------------------------------------------------------------------------------ 148

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 360 vpvenpedpqqnqeqqpppqppppepepveadflspfsvpeargdkvkwvfTWPLIFLLcvtipncskprwekffmvtFI 439
Cdd:COG0530  149 ---------------------------------------------------SLWKALLL-------------------LV 158

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 440 TATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPW 519
Cdd:COG0530  159 LGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGA 238

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300797299 520 GLQTMVVnygstvkiNSRGLVYSVVLLLGsVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCF 582
Cdd:COG0530  239 LITPIPV--------DPAVLSFDLPVMLA-ATLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 103-245 6.75e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.45  E-value: 6.75e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  103 HILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNIL 182
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300797299  183 CIIGVCGLFAGQVVRLTW----WAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIM 245
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 441-576 7.90e-11

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 63.51  E-value: 7.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 441 ATLWIAVFSYIM-------VWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILV 513
Cdd:PRK10734 175 AFLWLGIALIIMpmatrmvIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300797299 514 GLGVPWGLQTMVVNYGSTVKInsrglvYSVVLLLgSVALTVLGihlnkWRLDRKLG------------VYVLVLY 576
Cdd:PRK10734 255 VLGLPALISPGEINPLAFSRD------YWVMLLV-SVIFALLC-----WRRKRRIGrgagalllggfiVWLAMLY 317
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-587 3.45e-117

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 373.95  E-value: 3.45e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299    80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   237 LYVFYILIMKYN------VKMQAFFTVKQKSIANG------------------------------NPVNSELEAVKEKPQ 280
Cdd:TIGR00927  594 AYALYVFTMKWNkqielwVKEQLSRRPVAKVMALGdlskgdvaeaehtgertgeegerpteaegeNGEESGGEAEQEGET 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   281 YGKNPVVMVDEIMSS---------------------------SPPKFTFPE--------------------------AGL 307
Cdd:TIGR00927  674 ETKGENESEGEIPAErkgeqegegeieakeadhkgeteaeevEHEGETEAEgtedegeietgeegeevedegegeaeGKH 753

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   308 RIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVSSK----PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPP 382
Cdd:TIGR00927  754 EVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETG 833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   383 PEPEPV-----------------------------------------------EADFLSPFSV--PEARGDKVKWVFTWP 413
Cdd:TIGR00927  834 EQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYLFLLP 913

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   414 LIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQ 493
Cdd:TIGR00927  914 IVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARK 993

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299   494 GLGDMAVSNTIGSNVFDILVGLGVPWGLQTMvVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVL 573
Cdd:TIGR00927  994 GLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMF 1072

                          650
                   ....*....|....
gi 300797299   574 VLYAIFLCFSIMIE 587
Cdd:TIGR00927 1073 LLYFVFLIISVMLE 1086
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 102-579 3.06e-45

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 162.49  E-value: 3.06e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  102 LHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNI 181
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  182 LCIIGVCGLFAgQVVRLTWWaVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILimkynvkmqafFTVKQKS 261
Cdd:TIGR00367  81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLL-----------FLVKNER 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  262 IANGNPVNSEleavkekpqygknpvvmvdeimsssppkftfpeaglrimitnkfgprtrlrmasriiinerqrlinsang 341
Cdd:TIGR00367 148 WVKYDTYTEE---------------------------------------------------------------------- 157

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  342 vsskplQNGrheniengnvpvENPEDpqqnqeqqpppqppppepepveadflspfsvpeargdkvkwvftwPLIFllcvt 421
Cdd:TIGR00367 158 ------NLD------------ENNRR---------------------------------------------PQIF----- 169

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  422 ipncskprwekFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS 501
Cdd:TIGR00367 170 -----------FSLVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVG 238

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300797299  502 NTIGSNVFDILVGLGVPWGLQTMVVnygSTVKINSRGLVYSVVLLLgsvaltVLGIHLNKWRLDRKLGVYVLVLYAIF 579
Cdd:TIGR00367 239 NVIGSNIFNILVGLGVPSLFMPIPV---EPLAYNLDAPVMVIVTLL------LMLFFKTSMKLGRWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
120-582 1.49e-36

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 137.96  E-value: 1.49e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 120 DFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVRLT 199
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 200 WWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKmqafftvkqksiaNGNPVNSELEAVKEKP 279
Cdd:COG0530   80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRAR-------------KEPAWEEVEEELEEKP 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 280 QYgknpvvmvdeimsssppkftfpeaglrimitnkfgprtrlrmasriiinerqrlinsangvsskplqngrheniengn 359
Cdd:COG0530  147 KM------------------------------------------------------------------------------ 148

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 360 vpvenpedpqqnqeqqpppqppppepepveadflspfsvpeargdkvkwvfTWPLIFLLcvtipncskprwekffmvtFI 439
Cdd:COG0530  149 ---------------------------------------------------SLWKALLL-------------------LV 158

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 440 TATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPW 519
Cdd:COG0530  159 LGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGA 238

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300797299 520 GLQTMVVnygstvkiNSRGLVYSVVLLLGsVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCF 582
Cdd:COG0530  239 LITPIPV--------DPAVLSFDLPVMLA-ATLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 103-245 6.75e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.45  E-value: 6.75e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  103 HILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNIL 182
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300797299  183 CIIGVCGLFAGQVVRLTW----WAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIM 245
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 433-585 1.63e-25

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 102.68  E-value: 1.63e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  433 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDIL 512
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300797299  513 VGLGVPWGLQTMVVnYGSTVKINSRGLVYSVVLLLGSVALTVLgihLNKWRLDRKLGVYVLVLYAIFLCFSIM 585
Cdd:pfam01699  81 LVLGLSALIGPVKV-DSLLLKLDLGVLLLVALLLLLLLLLLLL---PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
79-245 1.12e-21

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 95.59  E-value: 1.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  79 DPAIHEFPTDLFSNKERQHGAVLLHILGALymfyALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASV 158
Cdd:COG0530  132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 159 IGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG-----QVVRLTWWAVcrdsvyyTISVIVLIVFIY-DEQIVWWEGL 232
Cdd:COG0530  208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPipvdpAVLSFDLPVM-------LAATLLLLGLLRtGGRIGRWEGL 280

                        170
                 ....*....|...
gi 300797299 233 VLIILYVFYILIM 245
Cdd:COG0530  281 LLLALYLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
463-587 1.66e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 71.32  E-value: 1.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 463 LGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVpwglqTMVVnygSTVKINSRGLVYS 542
Cdd:COG0530   15 LGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGL-----AALI---RPLAVDRRVLRRD 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 300797299 543 VVLLLGSVALTVLGIHLNkwRLDRKLGVYVLVLYAIFLCFSIMIE 587
Cdd:COG0530   87 LPFLLLASLLLLALLLDG--TLSRIDGVILLLLYVLYLYYLIRRA 129
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 108-238 1.30e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 70.98  E-value: 1.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  108 LYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGATFMAAGSSTPELFASVIGVF---ITHGD 167
Cdd:TIGR00845  83 VYMFLGVSIIADRFMAsievitsqekeitikkPNGETTVTTVRIwNETVSNLTLMALGSSAPEILLSVIEVCghnFEAGD 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  168 VGVGTIVGSAVFNILCIIGVCGLF--AGQVVRL----------TWwavcrdSVY-YTISVIVLIVFIYDEQIVwWEGLVL 234
Cdd:TIGR00845 163 LGPSTIVGSAAFNMFIIIAICVYVipDGETRKIkhlrvffvtaAW------SVFaYVWLYLILAVFSPGVVEV-WEGLLT 235


                  ....
gi 300797299  235 IILY 238
Cdd:TIGR00845 236 FFFF 239
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 436-554 7.08e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 68.67  E-value: 7.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  436 VTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLG-DMAVSNTIGSNVFDILVG 514
Cdd:TIGR00845 757 ACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLG 836

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 300797299  515 LGVPWGLQTMV-VNYGSTVKINSRGLVYSVVLLLGSVALTV 554
Cdd:TIGR00845 837 IGVAWSIAAIYhAANGTQFKVSPGTLAFSVTLFTIFAFICI 877
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 438-584 8.55e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 66.58  E-value: 8.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  438 FITATLWIAVFSY-IMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLG 516
Cdd:TIGR00367   6 YLILGLILLIYGAdLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILG 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300797299  517 vpwglqtmVVNYGSTVKINSRGLVYSVVLLLGSVALtvLGIHLNKWRLDRKLGVYVLVLYAIFLCFSI 584
Cdd:TIGR00367  86 --------LSAIFSPIIVDKDWLRRDILFYLLVSIL--LLFFGLDGQISRIDGVVLLILYIVYLLFLV 143
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 441-576 7.90e-11

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 63.51  E-value: 7.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 441 ATLWIAVFSYIM-------VWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILV 513
Cdd:PRK10734 175 AFLWLGIALIIMpmatrmvIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300797299 514 GLGVPWGLQTMVVNYGSTVKInsrglvYSVVLLLgSVALTVLGihlnkWRLDRKLG------------VYVLVLY 576
Cdd:PRK10734 255 VLGLPALISPGEINPLAFSRD------YWVMLLV-SVIFALLC-----WRRKRRIGrgagalllggfiVWLAMLY 317
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 452-586 1.52e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 62.74  E-value: 1.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 452 MVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNygST 531
Cdd:PRK10734  22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTVH--SD 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 300797299 532 VKINSRGLVYSVVLLLGSValtvlgihLNKWRLDRKLGVYVLVLYAIFLCFSIMI 586
Cdd:PRK10734 100 VLRRELPLMLLVSVLAGSV--------LYDGQLSRSDGIFLLLLAVLWLLFIVKI 146
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 98-584 1.90e-10

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 63.63  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  98 GAVLLHI-LGALymFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASvIGVFI--THGDVGVGTIV 174
Cdd:PLN03151 139 GYAVLGVwLVAL--FYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVgkDAGEVGLNSVL 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 175 GSAVFNILCIIGVCGL-FAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNV---- 249
Cdd:PLN03151 216 GGAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEilrk 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 250 -----KMQA---FFTVKQKSIANGN----PVNS---ELEAVKEKPQygknpvvmvdeiMSSSPPKFTFpeaglrimitnk 314
Cdd:PLN03151 296 harrlKLDVvtpLLPVQGSIFSPSVeedeSMYSpllESDTESDVPR------------LQTSLPQWMW------------ 351

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 315 fgprtrlrmASRIIINERQRLINSANGvSSKPLQNGRHENIENGNvPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLS 394
Cdd:PLN03151 352 ---------ASNVAIYSNHFAKGSVHD-EERPPWGWTDEGAEVES-SLFSCSKLFSLLEMPLTIPRRLTIPIVEEDRWSK 420

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 395 PFSVPEARGDKVKWVFTWP-----------LIFLLCVTI---------PNCSKPRWEKFFMVT-----FITATLWIAVFS 449
Cdd:PLN03151 421 TYAVASASLAPVLLAFLWSsqddvslqariAAYFIGVAIgstlgflayKYTEPDRPPRRFLIPwvlggFIMSIVWFYMIA 500

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299 450 YIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGlGD---MAVSNTIGSNVFDILVGLGVPWGLQTMVV 526
Cdd:PLN03151 501 NELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGMSMLLGAWSK 579

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 300797299 527 NYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSI 584
Cdd:PLN03151 580 SPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 99-192 1.39e-05

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 47.33  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797299  99 AVLLHILGALYMFYALAIVCDDFFVpslekICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAV 178
Cdd:PRK10734 175 AFLWLGIALIIMPMATRMVIDNATV-----LANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNI 249

                         90
                 ....*....|....
gi 300797299 179 FNILCIIGVCGLFA 192
Cdd:PRK10734 250 FNIVIVLGLPALIS 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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