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Conserved domains on  [gi|22330981|ref|NP_683550|]
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uncharacterized protein AT3G11300 [Arabidopsis thaliana]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 581124)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  8882580

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT1 super family cl23759
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 5-65 8.95e-11

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


The actual alignment was detected with superfamily member pfam12776:

Pssm-ID: 474047  Cd Length: 96  Bit Score: 56.55  E-value: 8.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330981     5 MWGHEHHKVFVDLCKEQKMLGNKPSGSG------RYGVDLFNA----------VISH-------------------MKWD 49
Cdd:pfam12776   1 YWTPEMDRYFVDLLLEQVNRGNRIEGHTfnkeawKEILAAFNAktgaqytkdqLKNRwdnlrkqyrlwkrllerpgFSWD 80

                          90
                  ....*....|....*.
gi 22330981    50 PQTKTFGASIRDWANY 65
Cdd:pfam12776  81 PTTRMVTATDEVWDNY 96
laccase super family cl37260
laccase, plant; Members of this protein family include the copper-containing enzyme laccase ...
 175-206 2.64e-07

laccase, plant; Members of this protein family include the copper-containing enzyme laccase (EC 1.10.3.2), often several from a single plant species, and additional, uncharacterized, closely related plant proteins termed laccase-like multicopper oxidases. This protein family shows considerable sequence similarity to the L-ascorbate oxidase (EC 1.10.3.3) family. Laccases are enzymes of rather broad specificity, and classification of all proteins scoring about the trusted cutoff of this model as laccases may be appropriate.


The actual alignment was detected with superfamily member TIGR03389:

Pssm-ID: 274556 [Multi-domain]  Cd Length: 539  Bit Score: 50.12  E-value: 2.64e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 22330981   175 GTIVILPKRCVPYPFPPPHTEKIIVFGEIFEA 206
Cdd:TIGR03389 116 GAIVILPKPGVPYPFPKPDREVPIILGEWWNA 147
GT1 super family cl23759
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 99-125 6.90e-05

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


The actual alignment was detected with superfamily member pfam12776:

Pssm-ID: 474047  Cd Length: 96  Bit Score: 40.38  E-value: 6.90e-05
                          10        20
                  ....*....|....*....|....*..
gi 22330981    99 YWSSSSHELLVDLLFQESLKGNRPIKT 125
Cdd:pfam12776   1 YWTPEMDRYFVDLLLEQVNRGNRIEGH 27
 
Name Accession Description Interval E-value
Myb_DNA-bind_3 pfam12776
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 5-65 8.95e-11

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 432776  Cd Length: 96  Bit Score: 56.55  E-value: 8.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330981     5 MWGHEHHKVFVDLCKEQKMLGNKPSGSG------RYGVDLFNA----------VISH-------------------MKWD 49
Cdd:pfam12776   1 YWTPEMDRYFVDLLLEQVNRGNRIEGHTfnkeawKEILAAFNAktgaqytkdqLKNRwdnlrkqyrlwkrllerpgFSWD 80

                          90
                  ....*....|....*.
gi 22330981    50 PQTKTFGASIRDWANY 65
Cdd:pfam12776  81 PTTRMVTATDEVWDNY 96
laccase TIGR03389
laccase, plant; Members of this protein family include the copper-containing enzyme laccase ...
 175-206 2.64e-07

laccase, plant; Members of this protein family include the copper-containing enzyme laccase (EC 1.10.3.2), often several from a single plant species, and additional, uncharacterized, closely related plant proteins termed laccase-like multicopper oxidases. This protein family shows considerable sequence similarity to the L-ascorbate oxidase (EC 1.10.3.3) family. Laccases are enzymes of rather broad specificity, and classification of all proteins scoring about the trusted cutoff of this model as laccases may be appropriate.


Pssm-ID: 274556 [Multi-domain]  Cd Length: 539  Bit Score: 50.12  E-value: 2.64e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 22330981   175 GTIVILPKRCVPYPFPPPHTEKIIVFGEIFEA 206
Cdd:TIGR03389 116 GAIVILPKPGVPYPFPKPDREVPIILGEWWNA 147
Myb_DNA-bind_3 pfam12776
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 99-125 6.90e-05

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 432776  Cd Length: 96  Bit Score: 40.38  E-value: 6.90e-05
                          10        20
                  ....*....|....*....|....*..
gi 22330981    99 YWSSSSHELLVDLLFQESLKGNRPIKT 125
Cdd:pfam12776   1 YWTPEMDRYFVDLLLEQVNRGNRIEGH 27
 
Name Accession Description Interval E-value
Myb_DNA-bind_3 pfam12776
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 5-65 8.95e-11

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 432776  Cd Length: 96  Bit Score: 56.55  E-value: 8.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330981     5 MWGHEHHKVFVDLCKEQKMLGNKPSGSG------RYGVDLFNA----------VISH-------------------MKWD 49
Cdd:pfam12776   1 YWTPEMDRYFVDLLLEQVNRGNRIEGHTfnkeawKEILAAFNAktgaqytkdqLKNRwdnlrkqyrlwkrllerpgFSWD 80

                          90
                  ....*....|....*.
gi 22330981    50 PQTKTFGASIRDWANY 65
Cdd:pfam12776  81 PTTRMVTATDEVWDNY 96
laccase TIGR03389
laccase, plant; Members of this protein family include the copper-containing enzyme laccase ...
 175-206 2.64e-07

laccase, plant; Members of this protein family include the copper-containing enzyme laccase (EC 1.10.3.2), often several from a single plant species, and additional, uncharacterized, closely related plant proteins termed laccase-like multicopper oxidases. This protein family shows considerable sequence similarity to the L-ascorbate oxidase (EC 1.10.3.3) family. Laccases are enzymes of rather broad specificity, and classification of all proteins scoring about the trusted cutoff of this model as laccases may be appropriate.


Pssm-ID: 274556 [Multi-domain]  Cd Length: 539  Bit Score: 50.12  E-value: 2.64e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 22330981   175 GTIVILPKRCVPYPFPPPHTEKIIVFGEIFEA 206
Cdd:TIGR03389 116 GAIVILPKPGVPYPFPKPDREVPIILGEWWNA 147
Myb_DNA-bind_3 pfam12776
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 99-125 6.90e-05

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 432776  Cd Length: 96  Bit Score: 40.38  E-value: 6.90e-05
                          10        20
                  ....*....|....*....|....*..
gi 22330981    99 YWSSSSHELLVDLLFQESLKGNRPIKT 125
Cdd:pfam12776   1 YWTPEMDRYFVDLLLEQVNRGNRIEGH 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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