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Conserved domains on  [gi|22129111|ref|NP_667099|]
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olfactory receptor family 4 subfamily K member 47 [Mus musculus]

Protein Classification

olfactory receptor family 4 protein( domain architecture ID 11607035)

olfactory receptor family 4 protein is an odorant receptor belonging to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
39-291 4.23e-140

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 396.19  E-value: 4.23e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15226  15 VLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15226  95 AFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYVLELM 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYSVI 278
Cdd:cd15226 175 VVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPVDKFLAVFYTVI 254
                       250
                ....*....|...
gi 22129111 279 TPLLNPVIYTLRN 291
Cdd:cd15226 255 TPLLNPIIYTLRN 267
 
Name Accession Description Interval E-value
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
39-291 4.23e-140

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 396.19  E-value: 4.23e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15226  15 VLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15226  95 AFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYVLELM 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYSVI 278
Cdd:cd15226 175 VVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPVDKFLAVFYTVI 254
                       250
                ....*....|...
gi 22129111 279 TPLLNPVIYTLRN 291
Cdd:cd15226 255 TPLLNPIIYTLRN 267
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
41-300 1.17e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 140.33  E-value: 1.17e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111    41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:pfam13853  11 GNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAV 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111   121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQdlntlMN 200
Cdd:pfam13853  91 DRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIK-----VN 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111   201 GECGILAVTC-----FILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYV---FPLNIT-WLDKF 270
Cdd:pfam13853 166 NIYGLFVVTStfgidSLLIVLSYGLILRTVLGiASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhrFGHNVPpLLQIM 245
                         250       260       270
                  ....*....|....*....|....*....|
gi 22129111   271 LAVFYSVITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:pfam13853 246 MANAYLFFPPVLNPIVYSVKTKQIRDCVKR 275
 
Name Accession Description Interval E-value
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
39-291 4.23e-140

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 396.19  E-value: 4.23e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15226  15 VLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15226  95 AFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYVLELM 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYSVI 278
Cdd:cd15226 175 VVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPVDKFLAVFYTVI 254
                       250
                ....*....|...
gi 22129111 279 TPLLNPVIYTLRN 291
Cdd:cd15226 255 TPLLNPIIYTLRN 267
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-291 1.17e-109

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 319.43  E-value: 1.17e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  40 SGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:cd13954  16 LGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAVMA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 120 YDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLM 199
Cdd:cd13954  96 YDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSLNELVI 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 200 NGECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPlNITW---LDKFLAVFY 275
Cdd:cd13954 176 FILAGFVGLGSFLLTLVSYIYIISTIlKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRP-SSSYssdLDKVVSVFY 254
                       250
                ....*....|....*.
gi 22129111 276 SVITPLLNPVIYTLRN 291
Cdd:cd13954 255 TVVTPMLNPIIYSLRN 270
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
39-291 5.75e-108

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 314.92  E-value: 5.75e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15939  15 VLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15939  95 AYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTYVIGLL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYSVI 278
Cdd:cd15939 175 VVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFPIDKVVAVFYTII 254
                       250
                ....*....|...
gi 22129111 279 TPLLNPVIYTLRN 291
Cdd:cd15939 255 TPMLNPLIYTLRN 267
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
41-291 9.33e-107

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 311.96  E-value: 9.33e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15936  17 GNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFLLSVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15936  97 DRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTFLLELLMV 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYSVITP 280
Cdd:cd15936 177 SNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPMDKAVSVLYTVITP 256
                       250
                ....*....|.
gi 22129111 281 LLNPVIYTLRN 291
Cdd:cd15936 257 MLNPMIYTLRN 267
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
41-298 5.20e-100

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 295.13  E-value: 5.20e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15225  17 GNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15225  97 DRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSLNEIAIF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFP--LNITWLDKFLAVFYSV 277
Cdd:cd15225 177 VASVLVILVPFLLILVSYIFIISTILKiPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPksSYSPETDKLLSLFYTV 256
                       250       260
                ....*....|....*....|.
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15225 257 VTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
39-298 1.97e-99

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 293.69  E-value: 1.97e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15421  15 LTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECLLLALM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15421  95 AYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADTSAYETV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFP--LNITWLDKFLAVFY 275
Cdd:cd15421 175 VYVSGVLFLLIPFSLILASYALILLTVLRmRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPgsYHSPEQDKVVSVFY 254
                       250       260
                ....*....|....*....|...
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15421 255 TILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
39-291 2.01e-97

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 288.25  E-value: 2.01e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15230  15 LVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15230  95 AYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHINELV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFP--LNITWLDKFLAVFY 275
Cdd:cd15230 175 LFAFSGFIGLSTLLIILISYLYILITIlRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPssSYSLDQDKVVSVFY 254
                       250
                ....*....|....*.
gi 22129111 276 SVITPLLNPVIYTLRN 291
Cdd:cd15230 255 TVVIPMLNPLIYSLRN 270
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
39-291 7.30e-97

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 286.69  E-value: 7.30e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15911  15 MAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYLLAVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQdlntL 198
Cdd:cd15911  95 SYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTS----L 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTC----FILLLISYTYILITVHQN-SKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLD--KFL 271
Cdd:cd15911 171 VELVTFILSSIVtlppFLLTLTSYICIISTILRIpSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSRDlnKVF 250
                       250       260
                ....*....|....*....|
gi 22129111 272 AVFYSVITPLLNPVIYTLRN 291
Cdd:cd15911 251 SLFYTVLTPLVNPLIYSLRN 270
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
39-298 7.90e-97

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 286.80  E-value: 7.90e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15229  15 LLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15229  95 AYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFANKMV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITW--LDKFLAVFY 275
Cdd:cd15229 175 LLTSSVIFGLGSFLLTLVSYIHIISTILRiRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSsvLDRVFSIQY 254
                       250       260
                ....*....|....*....|...
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15229 255 SILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
39-291 9.06e-96

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 283.95  E-value: 9.06e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15940  15 LSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15940  95 AYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTYLIDIL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYSVI 278
Cdd:cd15940 175 IVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSEDKVVSVFYTVV 254
                       250
                ....*....|...
gi 22129111 279 TPLLNPVIYTLRN 291
Cdd:cd15940 255 TPLLNPIIYTLRN 267
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
41-291 2.09e-94

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 280.50  E-value: 2.09e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHL-HSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:cd15935  17 GNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLTLMA 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 120 YDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLM 199
Cdd:cd15935  97 YDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTYVVEVLM 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 200 NGECGILAVTCFILLLISYTYILITVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYSVIT 279
Cdd:cd15935 177 VANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSSVDKVASVFYTLIT 256
                       250
                ....*....|..
gi 22129111 280 PLLNPVIYTLRN 291
Cdd:cd15935 257 PALNPLIYTLRN 268
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
40-291 2.41e-94

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 280.52  E-value: 2.41e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  40 SGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:cd15912  16 LGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLAVMS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 120 YDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLM 199
Cdd:cd15912  96 FDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRLIELLD 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 200 NGECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFP--LNITWLDKFLAVFYS 276
Cdd:cd15912 176 FILASVVLLGSLLLTIVSYIYIISTIlRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPsqSSSLDLNKVVALLNT 255
                       250
                ....*....|....*
gi 22129111 277 VITPLLNPVIYTLRN 291
Cdd:cd15912 256 VVTPLLNPFIYTLRN 270
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
41-298 1.17e-92

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 276.41  E-value: 1.17e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15235  18 GNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAY 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15235  98 DRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNELLIF 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDK--FLAVFYSV 277
Cdd:cd15235 178 TEGAVVVLGPFLLIVLSYARILAAVLKvPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSADKdrVATVMYTV 257
                       250       260
                ....*....|....*....|.
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15235 258 VTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
39-300 1.19e-92

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 276.45  E-value: 1.19e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15417  15 LLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFLLAAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMD---SQDL 195
Cdd:cd15417  95 AYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDtfiSQVV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 196 NTLMngeCGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFP--LNITWLDKFLA 272
Cdd:cd15417 175 LFLV---AVLFGVFSVLVVLISYGYIISTILKiRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPssSHSQDQDKVAS 251
                       250       260
                ....*....|....*....|....*...
gi 22129111 273 VFYSVITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:cd15417 252 VFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
41-298 1.73e-91

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 273.37  E-value: 1.73e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15231  17 GNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQdLNTLMN 200
Cdd:cd15231  97 DRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDTS-LNEVLL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGI-LAVTCFILLLISYTYILITVHQN-SKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWL--DKFLAVFYS 276
Cdd:cd15231 176 LVASVfIGLTPFLFIVISYVYIISTILKIrSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSLdkDTLISVLYS 255
                       250       260
                ....*....|....*....|..
gi 22129111 277 VITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15231 256 IVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
41-298 3.62e-91

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 272.66  E-value: 3.62e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15420  17 GNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15420  97 DRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTWINEILIF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFP--LNITWLDKFLAVFYSV 277
Cdd:cd15420 177 AGCVFILLGPFSLILISYLHILAAIlKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPgsSNSAEQEKILSLFYSL 256
                       250       260
                ....*....|....*....|.
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15420 257 FNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
11-302 4.69e-91

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 273.09  E-value: 4.69e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  11 EFVLLGLSNSKNLQVLLFLIFLLLYLLIMSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKK 90
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  91 TISFAGCMSQIFFSHCIASGEVVLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCG 170
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 171 PNKIDSFFCDMPLVIKLACMDSQDLNTLMNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMI 249
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRiHSSEGRRKAFSTCASHLMAVTI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22129111 250 FFLPCFFIYVFPLNITWL--DKFLAVFYSVITPLLNPVIYTLRNKEMKNAMKRFI 302
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
41-291 5.87e-91

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 271.61  E-value: 5.87e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15937  17 GNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFLLVAMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15937  97 DRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYTVELLMF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYSVITP 280
Cdd:cd15937 177 SNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSFPMDKVVAVFHTVIFP 256
                       250
                ....*....|.
gi 22129111 281 LLNPVIYTLRN 291
Cdd:cd15937 257 LLNPMIYTLRN 267
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
41-291 9.88e-91

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 271.07  E-value: 9.88e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15237  17 GNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15237  97 DRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSLNEAVIF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITW--LDKFLAVFYSV 277
Cdd:cd15237 177 VTSVLVLLIPFSLILASYIRILATILRiQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSpdQDKMISVFYTI 256
                       250
                ....*....|....
gi 22129111 278 ITPLLNPVIYTLRN 291
Cdd:cd15237 257 VTPMLNPLIYSLRN 270
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
41-291 9.93e-91

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 270.98  E-value: 9.93e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15938  17 GNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15938  97 DRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCVTELLMV 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHqnSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYSVITP 280
Cdd:cd15938 177 SNSGLISTVCFVVLVTSYTTILVTIR--STEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPVDKHVSVLYNVITP 254
                       250
                ....*....|.
gi 22129111 281 LLNPVIYTLRN 291
Cdd:cd15938 255 MLNPLIYTLRN 265
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-295 3.86e-90

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 270.35  E-value: 3.86e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  12 FVLLGLSNSKNLQVLLFLIFLLLYLLIMSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKT 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  92 ISFAGCMSQIFFSHCIASGEVVLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGP 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 172 NKIDSFFCDMPLVIKLACMDSQDLNTLMNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIF 250
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRmRSAEGRHKAFSTCASHLTAVTLF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129111 251 FLPCFFIYVFPL--NITWLDKFLAVFYSVITPLLNPVIYTLRNKEMK 295
Cdd:cd15408 241 YGSLAFMYLRPSsrYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
41-291 3.30e-89

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 267.25  E-value: 3.30e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15915  17 GNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAMLLAVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15915  97 DRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTSLNLWLLN 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ--NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWL--DKFLAVFYS 276
Cdd:cd15915 177 IVTGSIALGTFILTLLSYIYIISFLLLkvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLeqDRIVALLYT 256
                       250
                ....*....|....*
gi 22129111 277 VITPLLNPVIYTLRN 291
Cdd:cd15915 257 VVTPVLNPLIYTLRN 271
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
39-291 3.85e-89

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 267.01  E-value: 3.85e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15227  15 LTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15227  95 AYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEIG 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNIT--WLDKFLAVFY 275
Cdd:cd15227 175 VLVLSVCLGLGCFVFIIVSYVHIFSTVLRiPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSpsLLDLLLSVFY 254
                       250
                ....*....|....*.
gi 22129111 276 SVITPLLNPVIYTLRN 291
Cdd:cd15227 255 SVVPPTLNPIIYSLRN 270
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
39-298 7.91e-88

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 263.93  E-value: 7.91e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREK-KTISFAGCMSQIFFSHCIASGEVVLLAL 117
Cdd:cd15916  15 VLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFHFLGSTECFLYTL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 118 MAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNT 197
Cdd:cd15916  95 MAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADTTINEL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 198 LMNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYS 276
Cdd:cd15916 175 VIFASIGVVALGCFILILLSYGNIVRAILRiRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEALDGVIAVFYT 254
                       250       260
                ....*....|....*....|..
gi 22129111 277 VITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15916 255 VVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
41-300 1.09e-86

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 261.10  E-value: 1.09e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15411  17 GNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLGLMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15411  97 DRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHVNEMLIF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWL--DKFLAVFYSV 277
Cdd:cd15411 177 ILAGLTLVGSLLIILVSYTYILSTILKiRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLgqDKVASVFYTV 256
                       250       260
                ....*....|....*....|...
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:cd15411 257 VIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
39-291 4.26e-86

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 259.48  E-value: 4.26e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15947  15 LLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVLLAVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15947  95 AFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDTTFNELE 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLD--KFLAVFY 275
Cdd:cd15947 175 LFVASVFFLLVPLSLILVSYGFIARAVLRiKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQDqgKFISLFY 254
                       250
                ....*....|....*.
gi 22129111 276 SVITPLLNPVIYTLRN 291
Cdd:cd15947 255 TVVTPTLNPLIYTLRN 270
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
41-300 4.74e-85

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 257.24  E-value: 4.74e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15419  17 GNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLAAMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15419  97 DRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTFINELVMF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITW--LDKFLAVFYSV 277
Cdd:cd15419 177 VLCGLIIVSTILVILVSYAYILSTIlRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSpeQSKVVSVFYTL 256
                       250       260
                ....*....|....*....|...
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:cd15419 257 VIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
41-291 8.86e-85

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 256.00  E-value: 8.86e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15431  17 GNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLLLAVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVlLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15431  97 DRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLT-MPLHFCGPNVINHFFCEVQALLKLACSDTSLNEILMF 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWL--DKFLAVFYSV 277
Cdd:cd15431 176 ATSIFTLLLPFSFILVSYIRIGVAVlRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSdqDKIISVFYGV 255
                       250
                ....*....|....
gi 22129111 278 ITPLLNPVIYTLRN 291
Cdd:cd15431 256 VTPMLNPLIYSLRN 269
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
39-300 2.39e-84

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 255.41  E-value: 2.39e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15409  15 LVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15409  95 AYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPSINELV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWL--DKFLAVFY 275
Cdd:cd15409 175 LFIFSGSIQVFTILTVLISYSYILFTILKmKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALdqDMMDSLFY 254
                       250       260
                ....*....|....*....|....*
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:cd15409 255 TIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
39-291 3.44e-84

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 254.46  E-value: 3.44e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15918  15 VLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLLAVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15918  95 AYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDTHLNELV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPL--NITWLDKFLAVFY 275
Cdd:cd15918 175 ILVLGGLVGLVPFLCILVSYVRIVSAVLRiPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPssHSASKDSVAAVMY 254
                       250
                ....*....|....*.
gi 22129111 276 SVITPLLNPVIYTLRN 291
Cdd:cd15918 255 TVVTPMLNPFIYSLRN 270
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-302 1.66e-83

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 253.74  E-value: 1.66e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  12 FVLLGLSNSKNLQVLLFLIFLLLYLLIMSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKT 91
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  92 ISFAGCMSQIFFSHCIASGEVVLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGP 171
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 172 NKIDSFFCDMPLVIKLACMDSQDLNTLMNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIF 250
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRiRSAEGRQKAFSTCASHLTAITIF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129111 251 FLPCFFIYVFP--LNITWLDKFLAVFYSVITPLLNPVIYTLRNKEMKNAMKRFI 302
Cdd:cd15410 241 HGTILFMYCRPssSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
41-298 5.04e-83

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 251.97  E-value: 5.04e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15228  17 GNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLYTVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15228  97 DRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSIAETVSF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYSVIT 279
Cdd:cd15228 177 TNVGLVPLTCFLLILASYVRIVISILKmRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSPVLVTPVQIFNNVVT 256
                       250
                ....*....|....*....
gi 22129111 280 PLLNPVIYTLRNKEMKNAM 298
Cdd:cd15228 257 PMLNPLIYTLRNKEVKAAL 275
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
39-298 7.54e-82

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 248.89  E-value: 7.54e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15942  15 LSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFLYTVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQdLNTL 198
Cdd:cd15942  95 AYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTA-FNEL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MN-GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYS 276
Cdd:cd15942 174 VTfIDIGLVAMTCFLLILMSYVYIVSAILKiPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDPLDGVVAVFYT 253
                       250       260
                ....*....|....*....|..
gi 22129111 277 VITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15942 254 TVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
39-304 8.30e-82

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 248.88  E-value: 8.30e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15414  15 LLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFLLASM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15414  95 AYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQINKWV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWL--DKFLAVFY 275
Cdd:cd15414 175 LFIMAGALGVLSGLIILVSYIYILIAILRiRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLdlDKVVSVFY 254
                       250       260
                ....*....|....*....|....*....
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAMKRFIGK 304
Cdd:cd15414 255 TAVIPMLNPLIYSLRNKEVKDALRRTIRR 283
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
41-298 1.16e-81

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 248.45  E-value: 1.16e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15434  17 GNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVLLAVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15434  97 DRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLACVDTTAYEATIF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLD--KFLAVFYSV 277
Cdd:cd15434 177 ALGVFILLFPLSLILVSYGYIARAVLKiKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQDqgKFLTLFYTI 256
                       250       260
                ....*....|....*....|.
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15434 257 VTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
39-298 1.61e-80

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 245.39  E-value: 1.61e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15429  15 LLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFILLAVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15429  95 AYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSLNEVA 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNIT--WLDKFLAVFY 275
Cdd:cd15429 175 ILVSSVVVLLTPCFLVLLSYIHIISAILRiRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSsaLQEKMISLFY 254
                       250       260
                ....*....|....*....|...
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15429 255 AVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
39-300 3.46e-80

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 244.58  E-value: 3.46e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15416  15 LLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFLLAAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15416  95 AYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIRLAKIL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLD--KFLAVFY 275
Cdd:cd15416 175 PSISSGIIILVTVLTIIISYLYILIAILRiRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDqnKVVSVFY 254
                       250       260
                ....*....|....*....|....*
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:cd15416 255 MVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
41-300 4.73e-80

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 244.25  E-value: 4.73e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15415  17 GNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLLAVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15415  97 DRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTHINELLLL 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLD--KFLAVFYSV 277
Cdd:cd15415 177 TFSGVIAMSTLLTIIISYIFILFAILRiRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLEqeKVSAVFYTL 256
                       250       260
                ....*....|....*....|...
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:cd15415 257 VIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
39-291 5.73e-80

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 243.70  E-value: 5.73e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15232  15 LTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQdLNTL 198
Cdd:cd15232  95 AYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTS-LNEI 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGI-LAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWL--DKFLAVF 274
Cdd:cd15232 174 MAFVADVfFGVGNFLLTLTSYGFIIRSILRiRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPekDKVVAVL 253
                       250
                ....*....|....*..
gi 22129111 275 YSVITPLLNPVIYTLRN 291
Cdd:cd15232 254 YSVVTPTLNPLIYSLRN 270
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
41-291 2.82e-79

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 241.89  E-value: 2.82e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15430  17 GNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLAVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15430  97 DRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISLNEIIML 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFP--LNITWLDKFLAVFYSV 277
Cdd:cd15430 177 VGNIIFLVIPLLLICISYIFILSTILRiNSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPksKNAQISDKLITLFYGV 256
                       250
                ....*....|....
gi 22129111 278 ITPLLNPVIYTLRN 291
Cdd:cd15430 257 VTPMLNPIIYSLRN 270
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
39-300 6.28e-79

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 241.53  E-value: 6.28e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15412  15 LLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLAVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15412  95 AYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYVKETA 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWL--DKFLAVFY 275
Cdd:cd15412 175 MFIVAGFNLSSSLLIILISYLFILIAILRiRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVeqSKIVAVFY 254
                       250       260
                ....*....|....*....|....*
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:cd15412 255 TFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
41-298 7.16e-79

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 241.29  E-value: 7.16e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHS-PMYFLLANLSFVDMLLSSNTTPRMIIDFFR-EKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15941  17 GNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYAFHFLASTECFLYTVM 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15941  97 AYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADTTINELV 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAVFYSV 277
Cdd:cd15941 177 ILANIGIVAAGCFLLIVISYIYIVAAVLRiRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQAGAGAPAVFYTI 256
                       250       260
                ....*....|....*....|.
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15941 257 VTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-300 1.26e-78

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 241.19  E-value: 1.26e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  12 FVLLGLSNSKNLQVLLFLIFLLLYLLIMSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKT 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  92 ISFAGCMSQIFFSHCIASGEVVLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGP 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 172 NKIDSFFCDMPLVIKLACMDSQDLNTLMNGECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIF 250
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVlKIRSAEGRFKAFSTCASHLTAVGLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129111 251 FLPCFFIYVFPLNITWL--DKFLAVFYSVITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLdtDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
41-298 9.61e-78

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 238.48  E-value: 9.61e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15424  17 GNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGAMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15424  97 DRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHITEAIVF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITW--LDKFLAVFYSV 277
Cdd:cd15424 177 GAGVLILLVPLSVILTSYGLILASVLQmQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTpdRDKQIAVFYIV 256
                       250       260
                ....*....|....*....|.
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15424 257 ITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
42-291 1.40e-77

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 237.57  E-value: 1.40e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAYD 121
Cdd:cd15224  18 NLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAVMAYD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 122 RYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMNG 201
Cdd:cd15224  98 RYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSLAELVDFI 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 202 ECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLD--KFLAVFYSVI 278
Cdd:cd15224 178 LALIILLVPLLVTVASYICIISTVlRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSFDsnKLVSVLYTVV 257
                       250
                ....*....|...
gi 22129111 279 TPLLNPVIYTLRN 291
Cdd:cd15224 258 TPLLNPIIYCLRN 270
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
39-300 2.10e-74

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 230.05  E-value: 2.10e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15418  16 LVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLLAAM 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15418  96 AYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTRVYELI 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWL--DKFLAVFY 275
Cdd:cd15418 176 LYFILGFNVIAPTALILASYTFILAAILRiHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPdrDKVVALFY 255
                       250       260
                ....*....|....*....|....*
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:cd15418 256 TVVNPLLNPLIYSLRNKDVKEALKK 280
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
39-298 5.79e-74

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 228.62  E-value: 5.79e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15234  15 VLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLLAVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15234  95 AYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTLINNIL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYvFPLNIT---WLDKFLAVF 274
Cdd:cd15234 175 IYLATVIFGGIPLSGIIFSYYKIVSSIlRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVY-ISSAVThssRKTAVASVM 253
                       250       260
                ....*....|....*....|....
gi 22129111 275 YSVITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15234 254 YTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
16-302 7.83e-74

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 228.79  E-value: 7.83e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  16 GLSNSKNLQVLLFLIFLLLYLLIMSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFA 95
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  96 GCMSQIFFSHCIASGEVVLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKID 175
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 176 SFFCDMPLVIKLACmDSQDLNTLM---NGECGILAVTCFIllLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFF 251
Cdd:cd15406 161 HYFCDILPLLKLSC-SSTYINELLlfiVGGFNVLATTLAI--LISYAFILSSIlRIRSAEGRSKAFSTCSSHLAAVGVFY 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129111 252 LPCFFIYVFPLNITWLD--KFLAVFYSVITPLLNPVIYTLRNKEMKNAMKRFI 302
Cdd:cd15406 238 GSIIFMYLKPSSSSSMTqeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-302 1.14e-72

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 225.82  E-value: 1.14e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  12 FVLLGLSNSKNLQVLLFLIFLLLYLLIMSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKT 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  92 ISFAGCMSQIFFSHCIASGEVVLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGP 171
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 172 NKIDSFFCDMPLVIKLACMDSQDLNTLMNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIF 250
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRmRSAEGRRKAFSTCASHFTGVTLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129111 251 FLPCFFIYVFPLNITWL--DKFLAVFYSVITPLLNPVIYTLRNKEMKNAMKRFI 302
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLdqDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
41-291 3.00e-71

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 221.48  E-value: 3.00e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15914  17 GNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYLLTAMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15914  97 DRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTSLNVLVDF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYV-----FPLNitwLDKFLAVF 274
Cdd:cd15914 177 VIHAVIILLTFLLILLSYVKIISVVLKiPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLrlsksYSLD---YDRAIAVV 253
                       250
                ....*....|....*..
gi 22129111 275 YSVITPLLNPVIYTLRN 291
Cdd:cd15914 254 YAVLTPFFNPIIYSLRN 270
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
39-298 3.51e-70

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 218.89  E-value: 3.51e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15428  15 VLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALLSVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15428  95 SYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTHQAEMA 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNIT--WLDKFLAVFY 275
Cdd:cd15428 175 MFIMCVFTLVLPVLLILASYTRIIYTVfGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTskEYDKMISVFY 254
                       250       260
                ....*....|....*....|...
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15428 255 IIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
39-300 1.14e-69

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 217.96  E-value: 1.14e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQI-FFSHCIASgEVVLLAL 117
Cdd:cd15413  15 VMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLaFFLTFIIS-ELFLLSA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 118 MAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCD-MPLvIKLACMDSQDLN 196
Cdd:cd15413  94 MAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDdLPL-LALSCSDTHEKE 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 197 TLMNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWL--DKFLAV 273
Cdd:cd15413 173 LIILIFAGFNLISSLLIVLVSYLFILSAILRiRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLdtDKMASV 252
                       250       260
                ....*....|....*....|....*..
gi 22129111 274 FYSVITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:cd15413 253 FYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
41-291 2.71e-68

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 214.10  E-value: 2.71e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15913  17 GNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFLSVMAF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15913  97 DRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVPAPGTELICY 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFP--LNITWLDKFLAVFYSV 277
Cdd:cd15913 177 TLSSLIIFGTFLFILGSYTLVLRAVLRvPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPgsGNSTGMQKIVTLFYSV 256
                       250
                ....*....|....
gi 22129111 278 ITPLLNPVIYTLRN 291
Cdd:cd15913 257 VTPLLNPLIYSLRN 270
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
39-300 9.09e-68

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 213.05  E-value: 9.09e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15407  15 LVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFLLASM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15407  95 AYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDIHISEIV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFP--LNITWLDKFLAVFY 275
Cdd:cd15407 175 LFFLASFNVFFALLVILISYLFIFITILRmRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPssSHSMDTDKMASVFY 254
                       250       260
                ....*....|....*....|....*
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:cd15407 255 TMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
41-298 6.32e-67

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 210.80  E-value: 6.32e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15233  17 GNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFLLTAMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15233  97 DRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHLNELLLF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNI--TWLDKFLAVFYSV 277
Cdd:cd15233 177 VFAFFMALAPCVLIVVSYAHVVAAVLRiRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVysSDKDKVIGILNTV 256
                       250       260
                ....*....|....*....|.
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15233 257 LSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
41-298 7.63e-67

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 210.41  E-value: 7.63e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15432  17 GNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVLLAVMAF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15432  97 DRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTANEAELF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLD--KFLAVFYSV 277
Cdd:cd15432 177 VISVLLLLIPLGLILISYIFIVRAVLRiRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDrgKMVALFYGI 256
                       250       260
                ....*....|....*....|.
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15432 257 ITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
41-291 5.85e-66

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 208.10  E-value: 5.85e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15946  17 GNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQdLNTLMN 200
Cdd:cd15946  97 DRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTS-LNEMVD 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECG-ILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLN--ITWLDKFLAVFYS 276
Cdd:cd15946 176 FVLGvIVLVVPLSLILASYVNIFKAILKiRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSnySPERDKKISLFYN 255
                       250
                ....*....|....*
gi 22129111 277 VITPLLNPVIYTLRN 291
Cdd:cd15946 256 VFTALLNPVIYSLRN 270
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
41-298 2.83e-65

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 206.54  E-value: 2.83e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15236  17 GNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFLLAVMAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15236  97 DRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSLNELVIF 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVFP--LNITWLDKFLAVFYSV 277
Cdd:cd15236 177 TEGGLLFVLPLLLILGSYIRIAATILKvPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPssNNSSDKDIVASVMYTV 256
                       250       260
                ....*....|....*....|.
gi 22129111 278 ITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15236 257 VTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
39-298 3.70e-64

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 203.80  E-value: 3.70e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15405  15 VVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15405  95 AYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTYVNELV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLD--KFLAVFY 275
Cdd:cd15405 175 VFVVVGINIIVPSVTIFISYALILSNIlHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNqgKVSSVFY 254
                       250       260
                ....*....|....*....|...
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15405 255 TNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
39-298 2.82e-61

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 196.17  E-value: 2.82e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15433  15 LVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLAVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15433  95 AFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDETTEVQ 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLN--ITWLDKFLAVFY 275
Cdd:cd15433 175 MFVARVVILLLPAALILGSYGHVAHAVlRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHrySQAHGKFVSLFY 254
                       250       260
                ....*....|....*....|...
gi 22129111 276 SVITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15433 255 TVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
39-298 5.88e-56

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 182.49  E-value: 5.88e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15223  15 LVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESSILLVM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDsqdlnTL 198
Cdd:cd15223  95 ALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGD-----TT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCF-----ILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFF--LPCFFI-YVFPLNI-TWLD 268
Cdd:cd15223 170 INSIYGLAVAWLIvgsdiILIFFSYALILRAVLRlASGEARSKALNTCGSHLIVILFFYtaVLVSSLtYRFGKTIpPDVH 249
                       250       260       270
                ....*....|....*....|....*....|
gi 22129111 269 KFLAVFYSVITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15223 250 VLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
39-294 1.34e-55

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 181.33  E-value: 1.34e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15917  15 LLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESGVLLAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQdlNTL 198
Cdd:cd15917  95 AFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTR--VNS 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLI--SYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYV-------FPLNITWLd 268
Cdd:cd15917 173 IYGLFVALLIVGFDLLFIalSYVLILRAVLQlPSKEARLKALSTCGSHICVILIFYTPALFSFLthrfghhVPPHVHIL- 251
                       250       260
                ....*....|....*....|....*.
gi 22129111 269 kfLAVFYSVITPLLNPVIYTLRNKEM 294
Cdd:cd15917 252 --LANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
41-294 2.33e-54

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 178.34  E-value: 2.33e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15952  17 GNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAVLVAMAF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQdlntlMN 200
Cdd:cd15952  97 DRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASIR-----IN 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCF----ILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYV---FPLNIT-WLDKFL 271
Cdd:cd15952 172 IIYGLFAISVLvldvILIALSYVLILRAVfRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthrFGHNIPrYIHILL 251
                       250       260
                ....*....|....*....|...
gi 22129111 272 AVFYSVITPLLNPVIYTLRNKEM 294
Cdd:cd15952 252 ANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
39-293 6.60e-51

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 169.39  E-value: 6.60e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15221  15 LLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESAILLAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQdLNTL 198
Cdd:cd15221  95 AFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACADIT-VNIW 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTC-FILLLISYTYILITV-HQNSKTGASKALSTCTAHITVVMIFFLPCFF---IYVFPLNIT-WLDKFLA 272
Cdd:cd15221 174 YGLTVALLTVGLdVVLIAVSYALILRAVfRLPSKDARLKALSTCGSHVCVILMFYTPAFFsflTHRFGRHIPrHVHILLA 253
                       250       260
                ....*....|....*....|.
gi 22129111 273 VFYSVITPLLNPVIYTLRNKE 293
Cdd:cd15221 254 NLYVLVPPMLNPIVYGVKTKQ 274
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
39-294 2.52e-49

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 165.28  E-value: 2.52e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15950  15 LLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVLLAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDsqdlnTL 198
Cdd:cd15950  95 AFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACAD-----PR 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFI---LLLISYTYILI---TVHQNSKTGASKALSTCTAHITVVMIFFLPCFF-IYV--FPLNI-TWLD 268
Cdd:cd15950 170 PSSLYSITGSTLVVgtdSAFIAVSYGLIlraVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTqrFGQGVpPHTQ 249
                       250       260
                ....*....|....*....|....*.
gi 22129111 269 KFLAVFYSVITPLLNPVIYTLRNKEM 294
Cdd:cd15950 250 VLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
39-293 2.06e-47

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 160.36  E-value: 2.06e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEV-VLLAl 117
Cdd:cd15222  15 LLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESsVLLA- 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 118 MAYDRYVAICKPLHYFTIMNLKR--CTGLVLTSWTIGFLhgISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDsqdl 195
Cdd:cd15222  94 MAFDRFVAICNPLRYASILTNSRiaKIGLAIVLRSVLLL--LPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSD---- 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 196 nTLMNGECGILAVTC-----FILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPC--------FFIYVFP 261
Cdd:cd15222 168 -TRVNSIYGLFVVLStmgldSLLILLSYVLILKTVLGiASREERLKALNTCVSHICAVLIFYVPMiglsmvhrFGKHASP 246
                       250       260       270
                ....*....|....*....|....*....|..
gi 22129111 262 LnitwLDKFLAVFYSVITPLLNPVIYTLRNKE 293
Cdd:cd15222 247 L----VHVLMANVYLLVPPVLNPIIYSVKTKQ 274
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
41-293 1.44e-46

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 158.20  E-value: 1.44e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15953  17 GNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMESAVLVAMAF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNtlMN 200
Cdd:cd15953  97 DRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACGDTTINR--IY 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLI--SYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYV---FPLNIT-WLDKFLAV 273
Cdd:cd15953 175 GLVVALLVVGLDLLLIalSYALIIRAVLRlSSKKARQKALNTCTAHICVILMSYTPALFSFLthrFGQGIApHIHIILAN 254
                       250       260
                ....*....|....*....|
gi 22129111 274 FYSVITPLLNPVIYTLRNKE 293
Cdd:cd15953 255 LYLLVPPMLNPIIYGVKTKE 274
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
41-293 2.28e-46

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 157.51  E-value: 2.28e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15951  17 GNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGIFVAMAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDsqdlnTLMN 200
Cdd:cd15951  97 DRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACAD-----TRVS 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTC-----FILLLISYTYILITVHQNSKTGAS-KALSTCTAHITVVMIFFLPCFF---IYVFPLNIT-WLDKF 270
Cdd:cd15951 172 RAYGLSVAFLvggldVIFIAVSYIQILRAVFKLPSKEARlKTFGTCGSHICVILVFYIPALFsflTHRFGHNVPpHVHIL 251
                       250       260
                ....*....|....*....|...
gi 22129111 271 LAVFYSVITPLLNPVIYTLRNKE 293
Cdd:cd15951 252 IANVYLLVPPMLNPIIYGVRTKQ 274
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
41-295 3.22e-40

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 141.58  E-value: 3.22e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15948  18 GNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAVLLAMAF 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDsqdlnTLMN 200
Cdd:cd15948  98 DRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGD-----TRFN 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILL-----LISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFF---IYVFPLNIT-WLDKF 270
Cdd:cd15948 173 NIYGIAVALFIVGLdlmfiILSYVFILRAVLSlASKEEQLKAFGTCGSHICAILVFYTPVVLsstMHRFARHVApHVHIL 252
                       250       260
                ....*....|....*....|....*
gi 22129111 271 LAVFYSVITPLLNPVIYTLRNKEMK 295
Cdd:cd15948 253 LANFYLLFPPMMNPIVYGVKTKQIR 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
41-300 1.17e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 140.33  E-value: 1.17e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111    41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:pfam13853  11 GNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAV 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111   121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQdlntlMN 200
Cdd:pfam13853  91 DRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIK-----VN 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111   201 GECGILAVTC-----FILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYV---FPLNIT-WLDKF 270
Cdd:pfam13853 166 NIYGLFVVTStfgidSLLIVLSYGLILRTVLGiASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhrFGHNVPpLLQIM 245
                         250       260       270
                  ....*....|....*....|....*....|
gi 22129111   271 LAVFYSVITPLLNPVIYTLRNKEMKNAMKR 300
Cdd:pfam13853 246 MANAYLFFPPVLNPIVYSVKTKQIRDCVKR 275
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
39-294 2.00e-36

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 131.91  E-value: 2.00e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15956  15 LLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESGVLVAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRC--TGLVLTswtigfLHGISHVV----VLLQLPFCGPNKIDSFFCDMPLVIKLACMDS 192
Cdd:cd15956  95 ALDRFVAICNPLHYATILTLEVVakAGLLLA------LRGVAIVIpfplLVCRLSFCASHTIAHTYCEHMAVVKLACGAT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 193 QDLNtlMNGECGILAVTCFILLLISYTYILI--TVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFFIYVF----PLNIT 265
Cdd:cd15956 169 TVDS--LYGLALALFIGGGDVLFIAYSYGLIvkTVLRlPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMhrfgHSVPS 246
                       250       260
                ....*....|....*....|....*....
gi 22129111 266 WLDKFLAVFYSVITPLLNPVIYTLRNKEM 294
Cdd:cd15956 247 AAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
10-295 1.09e-34

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 127.59  E-value: 1.09e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  10 SEFVLLGLSNSKNLQVLLFLIFLLLYLLIMSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREK 89
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  90 KTISFAGCMSQIFFSHCIASGEVVLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFC 169
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 170 GPNKIDSFFCDMPLVIKLACMDSQdLNTLMNGECGILaVTCFILLLISYTYILI---TVHQNSKTGASKALSTCTAHITV 246
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVS-INNHYGLTIGFL-VLIMDSLFIVLSYIMIlrvVQRLATSEARLKTFGTCVSHVCA 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129111 247 VMIFFLPCF---FIYVFPLNITW-LDKFLAVFYSVITPLLNPVIYTLRNKEMK 295
Cdd:cd15949 240 ILAFYVPIAvssLIHRFGQNVPPpTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
39-294 4.22e-34

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 125.71  E-value: 4.22e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15954  15 MVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGVLMLM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDSQdlNTL 198
Cdd:cd15954  95 ALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIR--VDA 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MNGECGILAVTCFILLLISYTYILI---TVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPL----NIT-WLDKF 270
Cdd:cd15954 173 IYGLMVALLIGGFDILCISVSYAMIlraVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRfgghHITpHIHII 252
                       250       260
                ....*....|....*....|....
gi 22129111 271 LAVFYSVITPLLNPVIYTLRNKEM 294
Cdd:cd15954 253 MANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
41-294 2.53e-32

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 121.03  E-value: 2.53e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15955  17 GNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESGILLAMAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGL-VLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMDsqdlnTLM 199
Cdd:cd15955  97 DRYVAICHPLRHSSILTPQVLLGIgVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAADD-----VRV 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 200 NGECGILAVTCF-----ILLLISYTYILITVHQ-NSKTGASKALSTCTAHITVVMIFFLPCFF---IYVFPLNIT-WLDK 269
Cdd:cd15955 172 NKIYGLFVAFSIlgfdiIFITTSYALIFRAVFRlPQKEARLKAFNTCTAHIFVFLLFYTLAFFsffAHRFGHHVApYVHI 251
                       250       260
                ....*....|....*....|....*
gi 22129111 270 FLAVFYSVITPLLNPVIYTLRNKEM 294
Cdd:cd15955 252 LLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
41-287 1.06e-29

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 113.55  E-value: 1.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111    41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIID-FFREKKTISFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYyLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111   120 YDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNkidSFFCDMPLVIKLACmdsqdLNTLM 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSK-----PVSYT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111   200 NGECGILAVTCFILLLISYTYILITVHQNSKTGAS--------KALSTCTAHITVVMIFFLPCFFIYVFPLNI------T 265
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLAldcelsR 232
                         250       260
                  ....*....|....*....|....
gi 22129111   266 WLDKFLAV--FYSVITPLLNPVIY 287
Cdd:pfam00001 233 LLDKALSVtlWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
41-291 1.23e-21

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 91.97  E-value: 1.23e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd00637  15 GNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACMdsqdlntlmn 200
Cdd:cd00637  95 DRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKAYTIF---------- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 gECGILAVTCFILLLISYTYILITVHQNSKTGAS---------------KALSTCTAHITVVMIFFLPCFFIYVFPLNIT 265
Cdd:cd00637 165 -LFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSsssnssrrrrrrrerKVTKTLLIVVVVFLLCWLPYFILLLLDVFGP 243
                       250       260       270
                ....*....|....*....|....*....|..
gi 22129111 266 WLDKFLAVFYSVITPL------LNPVIYTLRN 291
Cdd:cd00637 244 DPSPLPRILYFLALLLaylnsaINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
40-298 4.12e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 67.97  E-value: 4.12e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  40 SGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFF--SHCIASgeVVLLAL 117
Cdd:cd14967  15 FGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALdvLCCTAS--ILNLCA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 118 MAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLhgISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLAcmdsqdlnt 197
Cdd:cd14967  93 ISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLL--ISLPPLVGWRDETQPSVVDCECEFTPNKIYVL--------- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 198 lmngecgILAVTCFIL--LLISYTYILITVHQNSKTGASKALStctahitVVMIFFLPC---FFIYVFPLNITWLDKFLA 272
Cdd:cd14967 162 -------VSSVISFFIplLIMIVLYARIFRVARRELKAAKTLA-------IIVGAFLLCwlpFFIIYLVSAFCPPDCVPP 227
                       250       260       270
                ....*....|....*....|....*....|..
gi 22129111 273 VFYSVITPL------LNPVIYTLRNKEMKNAM 298
Cdd:cd14967 228 ILYAVFFWLgylnsaLNPIIYALFNRDFRRAF 259
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
40-298 8.01e-13

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 67.62  E-value: 8.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  40 SGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:cd14969  16 VLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 120 YDRYVAICKPLHYFTImNLKRCTGLVLTSWTIGFLHGIshvvvllqLPFCGPNKIDsffcdmPLVIKLAC---MDSQDLN 196
Cdd:cd14969  96 FERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLFWAL--------PPLFGWSSYV------PEGGGTSCsvdWYSKDPN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 197 TLMNgeCGILAVTCFI--LLLISYTY--ILITVHQNSK----------TGASKALSTCTAHITVVMIFflpCFFIYVFP- 261
Cdd:cd14969 161 SLSY--IVSLFVFCFFlpLAIIIFCYykIYRTLRKMSKraarrknsaiTKRTKKAEKKVAKMVLVMIV---AFLIAWTPy 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 22129111 262 -----LNITWLDKFLAVFYSVITPLL-------NPVIYTLRNKEMKNAM 298
Cdd:cd14969 236 avvslYVSFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
42-298 6.51e-11

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 61.92  E-value: 6.51e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLHSPMYFLLANLSFVDML------------LSSNTTPRMIIDFFRekKTISFAGCMSQIFFshcias 109
Cdd:cd14972  16 NSLVLAAIIKNRRLHKPMYILIANLAAADLLagiafvftflsvLLVSLTPSPATWLLR--KGSLVLSLLASAYS------ 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 110 gevvLLALmAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGIshvvvllqLPFCGPNKIDsffCDMPLVIKLAC 189
Cdd:cd14972  88 ----LLAI-AVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGWNCVL---CDQESCSPLGP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 190 MDSQDLntlmngecGILAVTCFILLLIS----YTYILITVH---------QNSKTGASKALSTCTAhITVVMIF--FLPC 254
Cdd:cd14972 152 GLPKSY--------LVLILVFFFIALVIivflYVRIFWCLWrhanaiaarQEAAVPAQPSTSRKLA-KTVVIVLgvFLVC 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22129111 255 ---FFIY--VFPLNITWLDK--------FLAVFYSVItpllNPVIYTLRNKEMKNAM 298
Cdd:cd14972 223 wlpLLILlvLDVLCPSVCDIqavfyyflVLALLNSAI----NPIIYAFRLKEMRRAV 275
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
42-296 2.08e-08

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 54.47  E-value: 2.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILIT-TDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15085  17 NNVLVIAVTlKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSLTLLAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTsWTIGFLHGishVVVLLQLPFCGPNKIDSffcdmplviklACMDSQDLNTLMN 200
Cdd:cd15085  97 ERYNVVCKPMGGLKLSTKRGYQGLLFI-WLFCLFWA---VAPLFGWSSYGPEGVQT-----------SCSIGWEERSWSN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGIL-AVTCFIL--LLISYTY--ILITVHQNSKTGASKALSTCTA---HITVVMIFFLPCFFIYVFP----------- 261
Cdd:cd15085 162 YSYLILyFLMCFVIpvAIIGFSYgnVLRSLHKLNKKIEQQGGKNCPEeeeRAVIMVLAMVIAFLICWLPytvfalivvvn 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129111 262 --LNITWLDKFLAVFYSVITPLLNPVIYTLRNKEMKN 296
Cdd:cd15085 242 peLSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFRE 278
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
41-289 2.01e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 51.40  E-value: 2.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMII----------DFFrekktisfagCMSQIFFSHCIASG 110
Cdd:cd15055  17 GNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIrsietcwyfgDTF----------CKLHSSLDYILTSA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 111 EVVLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLhgISHVVVLLQLPFCGPNKIDSFFCDMPLVIklacm 190
Cdd:cd15055  87 SIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSAL--YSSVLLYDNLNQPGLIRYNSCYGECVVVV----- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 191 dsqdlntlmNGECGILA-VTCFIL----LLISYTYILITVHQ--------------------NSKTGASKALSTCTAHIT 245
Cdd:cd15055 160 ---------NFIWGVVDlVLTFILpctvMIVLYMRIFVVARSqarairshtaqvslegsskkVSKKSERKAAKTLGIVVG 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 22129111 246 VVMIFFLPCFFI-----YVFPLNITWlDKFLAVFYsvITPLLNPVIYTL 289
Cdd:cd15055 231 VFLLCWLPYYIVslvdpYISTPSSVF-DVLIWLGY--FNSCLNPLIYAL 276
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
41-298 3.10e-07

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 50.89  E-value: 3.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCmsQIFFSHCI--ASGEVVLLALM 118
Cdd:cd15073  17 SNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGC--QWYAFLNIffGMASIGLLTVV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTiMNLKRCTGLVLTSWTIGFLHGIshvvvllqLPFCGPNKIDSFFCDMPLVIKLACMDSQDLNTL 198
Cdd:cd15073  95 AVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAFFWAA--------MPLVGWASYALDPTGATCTINWRKNDSSFVSYT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 MngecgILAVTCFILLLISYTYILITVHQN-SKTGASKALS------TCTAHIT---VVMI-FFLPCFFIY--VFPLNIT 265
Cdd:cd15073 166 M-----SVIVVNFIVPLAVMFYCYYNVSRFvKKVLASDCLEsvnidwTDQNDVTkmsVIMIvMFLVAWSPYsiVCLWASF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 22129111 266 WLDKFLAVFYSVITPLL-------NPVIYTLRNKEMKNAM 298
Cdd:cd15073 241 GEPKKIPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
39-149 4.25e-07

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 50.41  E-value: 4.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGC----MSQIFFShcIASgeVVL 114
Cdd:cd15083  15 VVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCdmygFSGGLFG--IMS--INT 90
                        90       100       110
                ....*....|....*....|....*....|....*
gi 22129111 115 LALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSW 149
Cdd:cd15083  91 LAAIAVDRYLVITRPMKASVRISHRRALIVIAVVW 125
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
55-298 1.07e-06

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 49.48  E-value: 1.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  55 LHSPMYFLLANLSFVDMLL----SSNTTPRMIIDFFREKKTI-SFAGCMSQIffshciaSGEVVL--LALMAYDRYVAIC 127
Cdd:cd15084  41 LRSPLNYILVNLAVADLLVtlfgSSVSFSNNIVGFFVFGKTMcEFEGFMVSL-------TGIVGLwsLAILAFERYLVIC 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 128 KPLHYFTIMNLKRCTGLVLT-----SWTIGFLHGISHVVVLLQLPFCGPNKIDSffcdmplviklacmdsqdlNTLMNGE 202
Cdd:cd15084 114 KPMGDFRFQQRHAVSGCAFTwgwslLWTSPPLFGWSSYVPEGLRTSCGPNWYTG-------------------GTNNNSY 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 203 CGILAVTCFIL----LLISYTYILITV-----HQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNITWLDKFLAV 273
Cdd:cd15084 175 ILALFVTCFALplstIIFSYSNLLLTLravaaQQKESETTQRAEKEVTRMVIAMVMAFLICWLPYATFAMVVATNKDVVI 254
                       250       260       270
                ....*....|....*....|....*....|....
gi 22129111 274 ---------FYSVITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15084 255 qptlaslpsYFSKTATVYNPIIYVFMNKQFRSCL 288
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
42-161 1.17e-06

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 49.02  E-value: 1.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQ----IFFSHCIAS--GEVVLL 115
Cdd:cd15103  18 NILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnVIDSMICSSllASICSL 97
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129111 116 ALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVV 161
Cdd:cd15103  98 LAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFII 143
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
39-160 1.71e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 48.50  E-value: 1.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIID------FFREkktiSFAGCMSQIFFSHCIASgeV 112
Cdd:cd15312  15 VFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRsvescwYFGD----LFCKIHSSLDMMLSTTS--I 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129111 113 VLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHV 160
Cdd:cd15312  89 FHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVV 136
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
57-297 2.11e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 48.14  E-value: 2.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  57 SPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFF--SHCIASgeVVLLALMAYDRYVAICKPLHYFT 134
Cdd:cd15104  33 TKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFviTSCAAS--VLSLAAIAFDRYLALKQPLRYKQ 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 135 IMNLKRCTGLVLTSWTIGFLhgishvVVLLQLPFCGPNKID-----SFFCDM--PLVIKLACMdsqdlntlmngecgiLA 207
Cdd:cd15104 111 IMTGKSAGALIAGLWLYSGL------IGFLPLISPQFQQTSykgkcSFFAAFhpRVLLVLSCM---------------VF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 208 VTCFILLLISYTYILIT------------------VHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNIT---- 265
Cdd:cd15104 170 FPALLLFVFCYCDILKIarvhsraiykvehalarqIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQITGLVQALCDeckl 249
                       250       260       270
                ....*....|....*....|....*....|....
gi 22129111 266 --WLDKFLAvFYSVITPLLNPVIYTLRNKEMKNA 297
Cdd:cd15104 250 ydVLEDYLW-LLGLCNSLLNPWIYAFWQKEVRRA 282
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
39-289 2.18e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 48.36  E-value: 2.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTP-RMIIDFFREK-------KTISFAGCMSqiffshciASG 110
Cdd:cd14993  15 LVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPlTLLENVYRPWvfgevlcKAVPYLQGVS--------VSA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 111 EVVLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFlhgishvvvLLQLPFCGPNKIDSFFCDMPLVIKLA-C 189
Cdd:cd14993  87 SVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAI---------IIMLPLLVVYELEEIISSEPGTITIYiC 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 190 MDSQDLNTLMNGECGILAVTCFI--LLLISYTYILI--TVHQNSKTGASKALSTCTAH-------------ITVVMIFFL 252
Cdd:cd14993 158 TEDWPSPELRKAYNVALFVVLYVlpLLIISVAYSLIgrRLWRRKPPGDRGSANSTSSRrilrskkkvarmlIVVVVLFAL 237
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129111 253 pCFfiyvFPLNITWLDKFLAVFYSVITPLLNPVIYTL 289
Cdd:cd14993 238 -SW----LPYYVLSILLDFGPLSSEESDENFLLILPF 269
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
41-153 2.26e-06

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 48.34  E-value: 2.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GN-IVIQILITTdPHLHSPMYFLLANLSFVDMLLSSnTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:cd15079  17 GNgLVIYIFSTT-KSLRTPSNMLVVNLAISDFLMMI-KMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIGSIWTNAAIA 94
                        90       100       110
                ....*....|....*....|....*....|....
gi 22129111 120 YDRYVAICKPLHYfTIMNLKRCTGLVLTSWTIGF 153
Cdd:cd15079  95 YDRYNVIVKPLNG-NPLTRGKALLLILFIWLYAL 127
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
42-161 2.34e-06

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 47.98  E-value: 2.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLHSPMYFLLANLSFVDMLLS-SNTTPRMIIDFF------REKKTISFAGCMSQIFFSHCIASgeVVL 114
Cdd:cd15353  18 NILVIAAIAKNKNLHSPMYFFICSLAVADMLVSvSNGSETVVITLLngndtdAQSFTVNIDNVIDSVICSSLLAS--ICS 95
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22129111 115 LALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVV 161
Cdd:cd15353  96 LLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFII 142
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
42-150 2.85e-06

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 48.01  E-value: 2.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTI----SFAGCMSQIFFSH-CIA-SGEVVLL 115
Cdd:cd15354  18 NILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLviedAFVRHIDNVFDSLiCISvVASMCSL 97
                        90       100       110
                ....*....|....*....|....*....|....*
gi 22129111 116 ALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWT 150
Cdd:cd15354  98 LAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWT 132
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
41-297 3.05e-06

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 47.71  E-value: 3.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCmsQIFFSH----CIASgeVVLLA 116
Cdd:cd15064  17 GNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLC--DIWISLdvtcCTAS--ILHLC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 117 LMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGIShvvvllqlPFCG---PNKIDSffcdmplvikLACMDSQ 193
Cdd:cd15064  93 VIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLP--------PLFGwrtPDSEDP----------SECLISQ 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 194 DLNTLMNGECGILAVTcFILLLISYTYILITVHQNSKtgASKALSTctahITVVMIF-FLPcFFIYVFPLNITWLDKFLA 272
Cdd:cd15064 155 DIGYTIFSTFGAFYIP-LLLMLILYWKIYRAAARERK--AAKTLGI----ILGAFIVcWLP-FFLVALIVPLCSHCWIPL 226
                       250       260       270
                ....*....|....*....|....*....|.
gi 22129111 273 VFYSVIT------PLLNPVIYTLRNKEMKNA 297
Cdd:cd15064 227 ALKSFFLwlgyfnSLINPLIYTFFNKDFRKA 257
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
41-154 3.26e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 47.67  E-value: 3.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFF-REKKTISFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:cd14997  17 GNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWaREPWLLGEFMCKLVPFVELTVAHASVLTILAIS 96
                        90       100       110
                ....*....|....*....|....*....|....*
gi 22129111 120 YDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFL 154
Cdd:cd14997  97 FERYYAICHPLQAKYVCTKRRALVIIALIWLLALL 131
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
41-151 4.36e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 47.45  E-value: 4.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTI-SFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:cd15005  17 GNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSAFTLFCIA 96
                        90       100       110
                ....*....|....*....|....*....|..
gi 22129111 120 YDRYVAICKPLHYFTIMNLKRCTGLVLTSWTI 151
Cdd:cd15005  97 VTRYMAIAHHRFYAKRMTFWTCLAVICMAWTL 128
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
55-295 6.47e-06

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 46.71  E-value: 6.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  55 LHSPMYFLLANLSFVDMLLSSNttprmiidffreKKTISFAGCMSQIFFS---HCIASGEVVL---------LALMAYDR 122
Cdd:cd15082  44 LRQPLNYIIVNLSVADFLVSLT------------GGTISFLTNARGYFFLgvwACVLEGFAVTffgivalwsLAVLAFER 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 123 YVAICKPLHYFTIMNLKRCTGLVLT-----SWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCDMPLVIklacmdsqdlnt 197
Cdd:cd15082 112 FFVICRPLGNIRLQGKHAALGLLFVwtfsfIWTIPPVLGWSSYTVSKIGTTCEPNWYSGNMHDHTYII------------ 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 198 lmngecgILAVTCFIL----LLISYTYILITVHQNSKT-----GASKALSTCTAHITVVMIFFLPCFFIY-VFPLNIT-- 265
Cdd:cd15082 180 -------TFFTTCFILplgvIFVSYGKLLQKLRKVSNTqgrlgNARKPERQVTRMVVVMIVAFMVCWTPYaAFSILVTah 252
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129111 266 ---WLDKFLA---VFYSVITPLLNPVIYTLRNKEMK 295
Cdd:cd15082 253 ptiHLDPRLAaipAFFSKTAAVYNPIIYVFMNKQFR 288
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
40-297 9.46e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 46.58  E-value: 9.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  40 SGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPrmiIDFFREKKTISFA----GCMSQIFFSHCIASGEVVLL 115
Cdd:cd14979  16 VGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLP---VELYNFWWQYPWAfgdgGCKLYYFLFEACTYATVLTI 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 116 ALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWT--------IGFLHGISHvvvlLQLPFCGPNKiDSFFCDMPlvikl 187
Cdd:cd14979  93 VALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLvsilcaipILFLMGIQY----LNGPLPGPVP-DSAVCTLV----- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 188 acmdSQDLNTLMNGECGILAVTCFILLLISYTYILITV-----------HQNSKTGASKALSTCTAHITVVMIFFL--PC 254
Cdd:cd14979 163 ----VDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVklrsmrnikkgTRAQGTRNVELSLSQQARRQVVKMLGAvvIA 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129111 255 FFIYVFPLNITWL--------DKFLAVFYSVITPL----------LNPVIYTLRNKEMKNA 297
Cdd:cd14979 239 FFVCWLPFHAQRLmfsyaskeDTFLFDFYQYLYPIsgilfylssaINPILYNLMSSRFRVA 299
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
39-176 9.80e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 46.46  E-value: 9.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIidffrekkTIS------FAGCMSQIFFSHCIASGEV 112
Cdd:cd15069  15 VAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--------TISlgfctdFHSCLFLACFVLVLTQSSI 86
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22129111 113 VLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGIShvvvllqlPFCGPNKIDS 176
Cdd:cd15069  87 FSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLT--------PFLGWNKAMS 142
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
41-182 1.36e-05

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 45.78  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFF-REKKTISFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:cd15134  17 GNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWqQYPWVFGEVFCKLRAFLSEMSSYASVLTITAFS 96
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22129111 120 YDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGI-----SHVVVLLQLPFCGPNKIDSFFCDMP 182
Cdd:cd15134  97 VERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALpfaiqTRIVYLEYPPTSGEALEESAFCAML 164
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
42-151 1.90e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 45.16  E-value: 1.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFRE----KKTISFAGCMSQIFFSHCIAS--GEVVLL 115
Cdd:cd15350  18 NLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADmgylNRRGPFETKLDDIMDSLFCLSllGSIFSI 97
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 22129111 116 ALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTI 151
Cdd:cd15350  98 LAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTF 133
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
39-149 2.51e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 45.13  E-value: 2.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMII----------DFF-REKKTISFAGCMSQIFfshci 107
Cdd:cd15317  15 VSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIrtvetcwyfgDLFcKFHTGLDLLLCTTSIF----- 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22129111 108 asgevvLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSW 149
Cdd:cd15317  90 ------HLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGW 125
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
39-154 3.02e-05

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 44.57  E-value: 3.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGC--MSQIFFSHCIASgeVVLLA 116
Cdd:cd15001  14 LIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCkaVAYLQLLSFICS--VLTLT 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 22129111 117 LMAYDRYVAICKPL---HYFTIMNLKRCTGLVltsWTIGFL 154
Cdd:cd15001  92 AISIERYYVILHPMkakSFCTIGRARKVALLI---WILSAI 129
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
41-157 3.58e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 44.50  E-value: 3.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRM----IIDFFREKKTisFAGCMSQIFFSHCIASgeVVLLA 116
Cdd:cd15325  17 GNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSaifeILGYWAFGRV--FCNIWAAVDVLCCTAS--IMSLC 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 22129111 117 LMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGI 157
Cdd:cd15325  93 IISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISI 133
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
41-157 4.77e-05

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 44.17  E-value: 4.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFRekKTISFAGCMsqifFSHCI-----ASGEVVLL 115
Cdd:cd14968  17 GNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLG--LPTNFHGCL----FMACLvlvltQSSIFSLL 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22129111 116 ALmAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGI 157
Cdd:cd14968  91 AI-AIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGL 131
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
42-161 5.63e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 44.11  E-value: 5.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLHSPMYFLLANLSFVDMLLS-SNTTPRMIIDFFREKKTI---SFAGCMSQIFFSHCIAS--GEVVLL 115
Cdd:cd15352  18 NILVILAVVKNKNLHSPMYFFLCSLAVADMLVSvSNSLETIMIAVLNSGYLVisdQFIQHMDNVFDSMICISlvASICNL 97
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129111 116 ALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVV 161
Cdd:cd15352  98 LAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIV 143
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
41-297 6.09e-05

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 43.76  E-value: 6.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSnttprMIIDFFREKKTISF-----AGCMSQIFFSHCIASGEVVLL 115
Cdd:cd15321  23 GNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVAT-----LIIPFSLANELMGYwyfrkTWCEIYLALDVLFCTSSIVHL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 116 ALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTigflhgISHVVVLLQLPFCGPNKIDSffcdmplVIKLACMDSQDL 195
Cdd:cd15321  98 CAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWL------IAAVISLPPLIYKGKQKDEQ-------GGLPQCKLNEEA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 196 NTLMNGECGILAVTCFILLLisytyILITVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIY----VFPLNITWLDKFL 271
Cdd:cd15321 165 WYILSSSIGSFFAPCLIMIL-----VYLRIYLIAKNREKRFTFVLAVVIGVFVLCWFPFFFSYslgaICPELCKVPHSLF 239
                       250       260
                ....*....|....*....|....*...
gi 22129111 272 AVFYSV--ITPLLNPVIYTLRNKEMKNA 297
Cdd:cd15321 240 QFFFWIgyCNSSLNPVIYTIFNQDFRRA 267
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
39-298 6.18e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 43.85  E-value: 6.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLS-SNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLAL 117
Cdd:cd15337  15 VIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSaVNGFPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSITTLAA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 118 MAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGIshvvvllqLPFCGpnkidsFFCDMPLVIKLAC-MD--SQD 194
Cdd:cd15337  95 ISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSI--------PPFFG------WGRYVPEGFQTSCtFDylSRD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 195 LNTLMNGECGILAVTCFILLLISYTYILI--TVHQNSK----------------TGASKALSTCTAHITVVMI-FFLPCF 255
Cdd:cd15337 161 LNNRLFILGLFIFGFLCPLLIIIFCYVNIirAVRNHEKemtqtaksgmgkdtekNDARKKAEIRIAKVAIILIsLFLLSW 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129111 256 FIY--VFPLNITWLDKFLAVFYSVITPLL-------NPVIYTLRNKEMKNAM 298
Cdd:cd15337 241 TPYavVALLGQFGPAYWITPYVSELPVMFakasaiyNPIIYALSHPKFRAAL 292
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
42-298 7.30e-05

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 43.61  E-value: 7.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLHSPMYFLLANLSFVDM----------LLSSNTTPRM--IIDFFREkktisfaGCMsqifFSHCIAS 109
Cdd:cd15102  18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLlagaaylaniLLSGARTLRLspAQWFLRE-------GSM----FVALSAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 110 geVVLLALMAYDRYVAICKPLHYfTIMNLKRCTGLVLTSWTIGFLHGIshvvvllqLPFCGPNKIDSFfcdmplviklac 189
Cdd:cd15102  87 --VFSLLAIAIERHLTMAKMKPY-GASKTSRVLLLIGACWLISLLLGG--------LPILGWNCLGAL------------ 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 190 MDSQDLNTLMNGECGILAVTCFILLLIS----YTYILITVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPLNIT 265
Cdd:cd15102 144 DACSTVLPLYSKHYVLFCVTIFAGILAAivalYARIYCLVRASGRKATRASASPRSLALLKTVLIVLLVFIACWGPLFIL 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 22129111 266 WL----------------DKFLAVfySVITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15102 224 LLldvacpvktcpilykaDWFLAL--AVLNSALNPIIYTLRSRELRRAV 270
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
40-298 8.15e-05

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 43.59  E-value: 8.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  40 SGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:cd15012  15 FGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVVIS 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 120 YDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIdsfFCDMPLVIKLACMDSQDLNTLm 199
Cdd:cd15012  95 VERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDG---QEEEICVLDREMFNSKLYDTI- 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 200 ngECGILAVTCFILLLISYTYILITVHQNSKTGASKALSTCTahITVVMIFFLPCFFIYVFPLNITWLDKF--LAVFYSV 277
Cdd:cd15012 171 --NFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLL--VAVVVSFALCNLPYHARKMWQYWSEPYrcDSNWNAL 246
                       250       260       270
                ....*....|....*....|....*....|.
gi 22129111 278 ITPL----------LNPVIYTLRNKEMKNAM 298
Cdd:cd15012 247 LTPLtflvlyfnsaVNPLLYAFLSKRFRQSM 277
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
55-297 8.24e-05

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 43.25  E-value: 8.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  55 LHSPMYFLLANLSFVDMLLSSNTTPRMIIdfFREKKTISFAGCMSQIFFSH----CIASgeVVLLALMAYDRYVAICKPL 130
Cdd:cd15333  35 LHTPANYLIASLAVTDLLVSILVMPISIV--YTVTGTWTLGQVVCDIWLSSditcCTAS--ILHLCVIALDRYWAITDAV 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 131 HYFTIMNLKRCTGLVLTSWTIGflhgishvvVLLQLP--FCGPNKIDSffcdmplVIKLACMDSQDLNTLMNGECGILAV 208
Cdd:cd15333 111 EYSKKRTPKRAAVMIALVWVIS---------ISISLPpfFWRQAKAEE-------EVSECVVNTDHILYTVYSTVGAFYI 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 209 TCfILLLISYTYILITVHQNSKtgasKALSTCTAHITVVMIFFLPcFFIYVFPLNI----TWLDKFLAVFYS---VITPL 281
Cdd:cd15333 175 PT-LLLIALYGRIYVEARARER----KATKTLGIILGAFIVCWLP-FFIISLVLPIckdaCWFHLAIFDFFTwlgYLNSL 248
                       250
                ....*....|....*.
gi 22129111 282 LNPVIYTLRNKEMKNA 297
Cdd:cd15333 249 INPIIYTMSNEDFKQA 264
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-160 9.06e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 43.27  E-value: 9.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSS-NTTPRMIIDFfrekkTISFAGcmsQIFFSHCIASGEVV---- 113
Cdd:cd15387  15 LTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDI-----TFRFYG---PDFLCRLVKYLQVVgmfa 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129111 114 ---LLALMAYDRYVAICKPLHyftimNLKRCTG--LVLTSWTIGFLHGISHV 160
Cdd:cd15387  87 styMLLLMSIDRCLAICQPLR-----SLHRRSDrvYVLFSWLLSLVFSIPQV 133
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
39-297 1.04e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 43.04  E-value: 1.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15330  15 IFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGIShvvvllqlPFCG-PNKIDSFFCDmplviklACMDSQDLNT 197
Cdd:cd15330  95 ALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIP--------PMLGwRTPEDRSDPD-------ACTISKDPGY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 198 LMNGECGILAVTcFILLLISYTYILITVHQNSKTgaskalstcTAHITVVMIFFLPC---FFIYVFPLNI--------TW 266
Cdd:cd15330 160 TIYSTFGAFYIP-LILMLVLYGRIFKAAARERKT---------VKTLGIIMGTFILCwlpFFIVALVLPFcestchmpEL 229
                       250       260       270
                ....*....|....*....|....*....|..
gi 22129111 267 LDKFLA-VFYSviTPLLNPVIYTLRNKEMKNA 297
Cdd:cd15330 230 LGAIINwLGYS--NSLLNPIIYAYFNKDFQSA 259
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
42-151 1.32e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 42.60  E-value: 1.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAYD 121
Cdd:cd15335  18 NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALD 97
                        90       100       110
                ....*....|....*....|....*....|
gi 22129111 122 RYVAICKPLHYFTIMNLKRCTGLVLTSWTI 151
Cdd:cd15335  98 RYWAITDAIEYARKRTAKRAGLMILTVWTI 127
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
41-154 1.47e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 42.61  E-value: 1.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLS-SNTTPRMIIDFfrekkTISFAGcmsQIFFSHCIASGEVV------ 113
Cdd:cd15196  17 GNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlFNVLPQLIWDI-----TYRFYG---GDLLCRLVKYLQVVgmyass 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22129111 114 -LLALMAYDRYVAICKPLHYFTIMNlKRCTGLVLTSWTIGFL 154
Cdd:cd15196  89 yVLVATAIDRYIAICHPLSSHRWTS-RRVHLMVAIAWVLSLL 129
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
41-151 1.59e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 42.57  E-value: 1.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPrmiidfFREKKTISFAGCMSQIFFS--------HCIASgeV 112
Cdd:cd15326  17 GNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP------FSATLEILGYWVFGRIFCDiwaavdvlCCTAS--I 88
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 22129111 113 VLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTI 151
Cdd:cd15326  89 LSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVL 127
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
62-162 1.62e-04

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 42.40  E-value: 1.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  62 LLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAYDRYVAICKPLHYFTIMNlKRC 141
Cdd:cd15002  39 LILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQ-RRI 117
                        90       100
                ....*....|....*....|.
gi 22129111 142 TGLVLTSWTIGFLHGISHVVV 162
Cdd:cd15002 118 TAVVASIWVPACLLPLPQWLF 138
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
41-151 2.28e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 42.15  E-value: 2.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIdffREKKTISFAG---CMSQIFFSHCIASGEVVLLAL 117
Cdd:cd15318  17 GNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTI---RSVESCWYFGdsfCRLHTCLDTLFCLTSIFHLCF 93
                        90       100       110
                ....*....|....*....|....*....|....
gi 22129111 118 MAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTI 151
Cdd:cd15318  94 ISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLV 127
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
40-297 2.65e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 41.95  E-value: 2.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  40 SGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:cd15065  15 FGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILNLCAIS 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 120 YDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGIshvvVLLQLPFCGPNKIDSFFCDMPLVIKLACMdsQDLNTL- 198
Cdd:cd15065  95 LDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISF----LPIHLGWHRLSQDEIKGLNHASNPKPSCA--LDLNPTy 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 199 -MNGECGILAVTCFILLLIsYTYILITV----------------------------HQNSKTGASKALSTctahITVVMI 249
Cdd:cd15065 169 aVVSSLISFYIPCLVMLLI-YSRLYLYArkhvvniksqklpsesgskfqvpslsskHNNQGVSDHKAAVT----LGIIMG 243
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22129111 250 FFLPC---FFIY---------VFPLN----ITWLDKFLAVfysvitplLNPVIYTLRNKEMKNA 297
Cdd:cd15065 244 VFLICwlpFFIIniiaafcktCIPPKcfkiLTWLGYFNSC--------LNPIIYSIFNSEFRRA 299
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
41-151 2.78e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 41.71  E-value: 2.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPrmiidfFREKKTISFAGCMSQIFFS--------HCIASgeV 112
Cdd:cd15062  17 GNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP------FSATLEVLGYWAFGRIFCDvwaavdvlCCTAS--I 88
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 22129111 113 VLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTI 151
Cdd:cd15062  89 MSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVL 127
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
41-297 2.89e-04

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 41.84  E-value: 2.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMY-FLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFA-------GCMSQIFFShCIAS-GE 111
Cdd:cd14980  17 GNILVIIWHISSKKKKKKVPkLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSeewlrspPCLLACFLV-SLSSlMS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 112 VVLLALMAYDRYVAICKPLHYFtimNLKRCTglvlTSWTIGFLHGISHVVVLLQL----------------PFCGPNKID 175
Cdd:cd14980  96 VLMMLLITLDRYICIVYPFSNK---RLSYKS----AKIILILGWLFSIIFAAIPIlysinqpgdnrlygysSICMPSNVS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 176 SFFCDMPLVIKLACMdsqdlntlmngecgilaVTCFILLLISYTYILITVHQNSKtgASKALSTCTAHITVV-------- 247
Cdd:cd14980 169 NPYYRGWLIAYLLLT-----------------FIAWIIICILYILIFISVRKSRK--SARRSSSKRDKRIAIrlalilit 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22129111 248 -MIFFLPCFFIYV-FPLNITWLD----KFLAVFYSVITPLLNPVIYTLRNKEMKNA 297
Cdd:cd14980 230 dLICWLPYYIVIFsGLLTSTEIDihvlQFIAILALPLNSAINPYLYTLTTPTFKRD 285
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
39-154 6.60e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 40.55  E-value: 6.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLlssnTTPRMIIDFFREKKTISF----AGCMSQIFFSHCIASGEVVL 114
Cdd:cd15928  15 ASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLL----IFLVLPLDLYRLWRYRPWrfgdLLCRLMYFFSETCTYASILH 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 22129111 115 LALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFL 154
Cdd:cd15928  91 ITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIV 130
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
41-159 6.94e-04

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 40.74  E-value: 6.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15096  17 GNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSL 96
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTI--------GFLHGISH 159
Cdd:cd15096  97 DRYLAVVHPITSMSIRTERNTLIAIVGIWIVilvanipvLFLHGVVS 143
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
41-297 7.76e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 40.31  E-value: 7.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15323  17 GNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGflhgishvvVLLQLPfcgpnKIDSFFCDMPLVIKLACMDSQDLNTLMN 200
Cdd:cd15323  97 DRYWSVTQAVEYNLKRTPRRVKAIIVTVWLIS---------AVISFP-----PLISMYRDPEGDVYPQCKLNDETWYILS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLisytyILITVHQNSKTGASKAlstcTAHITVVMIFFLPCFFIYVFPLNITWL--------DKFLA 272
Cdd:cd15323 163 SCIGSFFAPCLIMIL-----VYIRIYRVAKAREKRF----TFVLAVVMGVFVVCWFPFFFSYSLYGIcreacevpEPLFK 233
                       250       260
                ....*....|....*....|....*..
gi 22129111 273 VFYSV--ITPLLNPVIYTLRNKEMKNA 297
Cdd:cd15323 234 FFFWIgyCNSSLNPVIYTIFNQDFRRS 260
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
41-298 9.95e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 39.94  E-value: 9.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd14982  17 GNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYINMYGSILFLTCISV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGIShvVVLLQLPFCGPNKIDSFFCDMPLVIKLACmdsqdlnTLMN 200
Cdd:cd14982  97 DRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVP--LLLLRSTIAKENNSTTCFEFLSEWLASAA-------PIVL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTCFILLLISYTYILITVHQNSKTGAS-----KALSTCTAHITVVMIFFLP---CFFIYV-----FPLNITWL 267
Cdd:cd14982 168 IALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKsvrkrKALRMILIVLAVFLVCFLPyhvTRILYLlvrlsFIADCSAR 247
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129111 268 DkFLAVFYSVITPL------LNPVIYTLRNKEMKNAM 298
Cdd:cd14982 248 N-SLYKAYRITLCLaslnscLDPLIYYFLSKTFRKRL 283
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
41-297 1.22e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 39.60  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTP-RMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMA 119
Cdd:cd15052  17 GNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLFCTASIMHLCTIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 120 YDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFlhGIShvvvllqlpfcgpnkidsffcdMPLVIkLACMDsqDLNTLM 199
Cdd:cd15052  97 LDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISI--GIS----------------------SPIPV-LGIID--TTNVLN 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 200 NGECGIL--------AVTCFI--LLLISYTYILITVHQNSKTGASKALStctahiTVVMIFFL---PCFFIYVFP----- 261
Cdd:cd15052 150 NGTCVLFnpnfviygSIVAFFipLLIMVVTYALTIRLLSNEQKASKVLG------IVFAVFVIcwcPFFITNILTglcee 223
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129111 262 LNITWLDKFLAVF--YSVITPLLNPVIYTLRNKEMKNA 297
Cdd:cd15052 224 CNCRISPWLLSVFvwLGYVSSTINPIIYTIFNKTFRRA 261
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
115-298 1.38e-03

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 39.81  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 115 LALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTsWTIGFLHGIShvvvllqlPFCGPNKIdsffcdMPLVIKLAC-MDSQ 193
Cdd:cd15077  91 LAVVAFERFLVICKPLGNFTFRGTHAIIGCIAT-WVFGLAASLP--------PLFGWSRY------IPEGLQCSCgPDWY 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 194 DLNTLMNGECGILAVTCFI------LLLISYTYILITVH-----QNSKTGASKALSTCTAHITVVMIFFLPCFFIY-VFP 261
Cdd:cd15077 156 TTNNKWNNESYVMFLFCFCfgvplsIIVFSYGRLLLTLRavakqQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYaSFA 235
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 22129111 262 LNITW-----LDKFLAVFYSVI---TPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15077 236 LWVVTnrgepFDLRLASIPSVFskaSTVYNPVIYVFMNKQFRSCM 280
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
42-149 1.40e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 39.78  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLHSPMYFLLANLSFVDMLLS-SNTTPRMIIDFFREKKTISFAGCMSQI-----FFSHCIASGEVVLL 115
Cdd:cd15351  18 NILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSvSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidTMICSSVVSSLSFL 97
                        90       100       110
                ....*....|....*....|....*....|....
gi 22129111 116 ALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSW 149
Cdd:cd15351  98 GAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIW 131
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
41-160 1.51e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 39.54  E-value: 1.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIqILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQI-----FFSHCIASGEVVLL 115
Cdd:cd14978  17 GNILN-LVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyiyPLANTFQTASVWLT 95
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 22129111 116 ALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHV 160
Cdd:cd14978  96 VALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRF 140
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
39-164 1.70e-03

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 39.53  E-value: 1.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIdffrekktISFAGCM-SQIFFSHCIASGEVVL--- 114
Cdd:cd15314  15 VCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMV--------RSVETCWyFGDLFCKIHSSFDITLcta 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129111 115 ----LALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVLL 164
Cdd:cd15314  87 silnLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLEL 140
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
41-155 1.79e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 39.44  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15215  16 GNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSV 95
                        90       100       110
                ....*....|....*....|....*....|....*
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLH 155
Cdd:cd15215  96 DRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQ 130
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
98-167 1.85e-03

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 39.42  E-value: 1.85e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22129111  98 MSQIFFSHCiasgEVVLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHVVVL----LQLP 167
Cdd:cd15143  87 LSMVFYGLC----PLLLGATMAVERFFGINRPFSRSTAMSKRRAWYMVGMVWAFAFLLGLLPILGLgrytLQYP 156
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
41-225 1.85e-03

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 39.41  E-value: 1.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15202  17 GNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLTAIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTimNLKRCTGLVLTSWTIGFLHGISHVVVLLQLPFCGPNKIDSFFCdMPLVIKLACMDSQDLNtlmn 200
Cdd:cd15202  97 DRYQAIMHPLKPRI--SKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLC-LEDWPERADLFWKYYD---- 169
                       170       180
                ....*....|....*....|....*....
gi 22129111 201 gecgiLAVTCFI----LLLISYTYILITV 225
Cdd:cd15202 170 -----LALFILQyflpLLVISFAYARVGI 193
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
41-296 1.92e-03

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 39.15  E-value: 1.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIdfFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15068  17 GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGISHvvvLLQLPFCGP---NKIDSFFCDMPLViklACM--DSQDL 195
Cdd:cd15068  95 DRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTP---MLGWNNCGQpkeGKNHSQGCGEGQV---ACLfeDVVPM 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 196 NTLMNGECGILAVTCFILLLISYTYILITVHQNSKTGASKALSTCTAHIT-------------VVMIF---FLPCFFIYV 259
Cdd:cd15068 169 NYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTlqkevhaakslaiIVGLFalcWLPLHIINC 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 22129111 260 FPLNITWLDK------FLAVFYSVITPLLNPVIYTLRNKEMKN 296
Cdd:cd15068 249 FTFFCPDCSHaplwlmYLAIVLSHTNSVVNPFIYAYRIREFRQ 291
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
42-298 2.14e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 39.05  E-value: 2.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLH-SPMYFLLANLSFVDmLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15341  18 NVAVLYLILSSPKLRrKPSYLFIGSLALAD-FLASVVFACSFVDFHVFHGVDSSAIFLLKLGGVTMSFTASLGSLLLMAF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLhgishvvvLLQLPFCGPNKIDSffcDMPLVIKLACMDSQDLNTLMn 200
Cdd:cd15341  97 DRYVCIYYPSEYKALVTRKRALVALAVMWVLTAL--------IAYLPLMGWNCCPL---NSPCSELFPLIPNDYLLSWL- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 gecgILAVTCFILLLISYTYILITVHQ--------NSKTGASKA--------LSTCTAHITVVMIFFLPCFFIYVFPLNI 264
Cdd:cd15341 165 ----LLVAILLSGIIYTYGHVLWKAHKhvvymekhQDQQGPGNArmrldvrlAKTLGLVLAVLLICWSPVLALMMHSLFT 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129111 265 TWLDKFLAVF-----YSVITPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15341 241 SLSDHIKKAFafcstLCLVNSMVNPIIYALRSRELRSSL 279
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
39-297 2.15e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 39.15  E-value: 2.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTP-RMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLAL 117
Cdd:cd15304  15 IAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 118 MAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFlhGISHVVVLLQLPfcgpnkidsffcDMPLVIKLACMDSQDLNT 197
Cdd:cd15304  95 ISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISV--GISMPIPVFGLQ------------DDSKVFKEGSCLLADENF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 198 LMNGECGILAVTcFILLLISYtYILITVHQNSKTGASKALSTCTAHITVVMIFFLPCFFIYVFPL------NITWLDKFL 271
Cdd:cd15304 161 VLIGSFVAFFIP-LTIMVITY-FLTIKSLQQSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVickescNEVVIGGLL 238
                       250       260
                ....*....|....*....|....*...
gi 22129111 272 AVFYSV--ITPLLNPVIYTLRNKEMKNA 297
Cdd:cd15304 239 NVFVWIgyLSSAVNPLVYTLFNKTYRSA 266
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
39-151 2.61e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 39.16  E-value: 2.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKK-TISFAGCMSQIFFSHCIASGEVVLLAL 117
Cdd:cd15217  15 LAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVLFCFHAAFMLFC 94
                        90       100       110
                ....*....|....*....|....*....|....
gi 22129111 118 MAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTI 151
Cdd:cd15217  95 ISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTL 128
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
39-302 2.90e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 38.73  E-value: 2.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKK-TISFAGCMSQIFFSHCIASGEVVLLAL 117
Cdd:cd15305  15 IGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVLFSTASIMHLCA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 118 MAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFlhGIShvvvlLQLPFCGPNKIDSFFCDMPLVIklacmdsQDLNT 197
Cdd:cd15305  95 ISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISI--GIS-----MPIPVIGLQDDEKVFVNGTCVL-------NDENF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 198 LMNGEcgilAVTCFILLLISYTYILITVHQNSKTGASKALSTCTAHITVVMIFFL----PCFFIYVFPL------NITWL 267
Cdd:cd15305 161 VLIGS----FVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLimwcPFFITNILSVlckeacDQKLM 236
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129111 268 DKFLAVFYSV--ITPLLNPVIYTLRNKEMKNAMKRFI 302
Cdd:cd15305 237 EELLNVFVWVgyVSSGINPLVYTLFNKTYRRAFSNYI 273
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-180 2.96e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 38.91  E-value: 2.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  39 MSGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALM 118
Cdd:cd15208  15 LVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSVSVLTLSCI 94
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22129111 119 AYDRYVAICKPLHYFTimNLKRCTGLVLTSWTIGFLHGISHVVVL-LQLPFCGPNKIDSF-FCD 180
Cdd:cd15208  95 ALDRWYAICHPLMFKS--TAKRARVSILIIWIVSLLIMIPQAIVMeCSRVVPLANKTILLtVCD 156
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
41-149 3.02e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 38.49  E-value: 3.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREkKTISFAGCMSQIFFSHCIASGEVVLLAL--M 118
Cdd:cd15067  16 GNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTG-GYWLFGRDWCDVWHSFDVLASTASILNLcvI 94
                        90       100       110
                ....*....|....*....|....*....|.
gi 22129111 119 AYDRYVAICKPLHYFTIMNLKRCTGLVLTSW 149
Cdd:cd15067  95 SLDRYWAITDPISYPSRMTKRRALIMIALVW 125
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
41-297 4.53e-03

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 38.10  E-value: 4.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15331  17 GNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKpLHYFTIMNLKRCTGLVLTSWTIGFLHGIShvvvllqlPFCGPNKIDsfFCDMPLVIKlACMDSQDLNTLMN 200
Cdd:cd15331  97 DRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIA--------PLFGWKDED--DLDRVLKTG-VCLISQDYGYTIF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 201 GECGILAVTcFILLLISYTYILITVHQNSKtgASKALSTCTAhitVVMIFFLPcFFIY--VFPLNITW-LDKFLAVFY-- 275
Cdd:cd15331 165 STVGAFYVP-LLLMIIIYWKIYQAAKRERK--AARTLAIITG---AFVVCWLP-FFLValVMPFCGAWqISRFLESFFlw 237
                       250       260
                ....*....|....*....|...
gi 22129111 276 -SVITPLLNPVIYTLRNKEMKNA 297
Cdd:cd15331 238 lGYFNSLLNPIIYTIFSPDFRGA 260
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
41-298 4.97e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 37.86  E-value: 4.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  41 GNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAY 120
Cdd:cd15054  17 GNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASILNLCVISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 121 DRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFL----------HGISHVVVLLQLPFCGPNKIDSFFCDMPLVIKLACm 190
Cdd:cd15054  97 DRYLLIISPLRYKLRMTPPRALALILAAWTLAALasflpielgwHELGHERTLPNLTSGTVEGQCRLLVSLPYALVASC- 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 191 dsqdlntlmngecgilaVTCFI-LLLISYTYILITVhqnSKTGASKALSTCTAHITVVMIFFLPCF-------FIYVFPL 262
Cdd:cd15054 176 -----------------LTFFLpSGAICFTYCRILL---AARKALKASLTLGILLGMFFVTWLPFFvanvvqaVCDCVSP 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 22129111 263 N----ITWLDKFlavfysviTPLLNPVIYTLRNKEMKNAM 298
Cdd:cd15054 236 GlfdvLTWLGYC--------NSTMNPIIYPLFMRDFKRAL 267
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
43-299 5.63e-03

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 37.62  E-value: 5.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  43 IVIQILITTDpHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFAGCMSQIFFSHCIASGEVVLLALMAYDR 122
Cdd:cd15334  20 LVITAIIVTR-KLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALDR 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 123 YVAICKPLHYFTIMNLKRCTGLVLTSWTIGflhgishvvVLLQLPfcgpnkidsffcdmPLVIKLACMDSQDLNTLMNGE 202
Cdd:cd15334  99 YRAITDAVEYARKRTPKHAGIMIAVVWIIS---------IFISMP--------------PLFWRHQTTSREDECIIKHDH 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 203 CGILAVTCFILLLISYTYILITVHQ--NSKTGASKALSTCTAHITVVMIFFLPcFFIYVFPLNI-------TWLDKFLAv 273
Cdd:cd15334 156 IVFTIYSTFGAFYIPLALILILYYKiyRAATRERKAATTLGLILGAFVICWLP-FFVKEVIVNTcdscyisEEMSNFLT- 233
                       250       260
                ....*....|....*....|....*.
gi 22129111 274 FYSVITPLLNPVIYTLRNKEMKNAMK 299
Cdd:cd15334 234 WLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
42-298 6.49e-03

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 37.60  E-value: 6.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  42 NIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISFagcMSQIFFSHCIASGEVVLLALMAyD 121
Cdd:cd15962  18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETISL---ITVGFLVASFTASVSSLLAITV-D 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 122 RYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFLHGIshvvvllqLPFCGPNKIDSffcdmplviKLACmdsQDLNTLMNG 201
Cdd:cd15962  94 RYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGL--------LPVLGWNCLEE---------RASC---SIVRPLTKS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 202 ECGILAVT---CFILLLISYTYILITV----HQ----------NSKTGASKALSTCTAHITVVMIFFLPcFFIYV----- 259
Cdd:cd15962 154 NVTLLSASfffIFILMLHLYIKICKIVcrhaHQialqqhfltaSHYVATKKGVSTLAIILGTFGASWLP-FAIYCvvgdh 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 22129111 260 -FPLNITWLDKFLAVFYSVItpllNPVIYTLRNKEMKNAM 298
Cdd:cd15962 233 eYPAVYTYATLLPATYNSMI----NPIIYAYRNQEIQRSM 268
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
54-154 7.38e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 37.52  E-value: 7.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  54 HLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTISF--AGCMSQIFFSHCIASGEVVLLALMAYDRYVAICKPLH 131
Cdd:cd15355  33 HLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFgdAACRGYYFLRDACTYATALNVASLSVERYLAICHPFK 112
                        90       100
                ....*....|....*....|...
gi 22129111 132 YFTIMNLKRCTGLVLTSWTIGFL 154
Cdd:cd15355 113 AKSLMSRSRTKKFISAIWLASAL 135
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
106-297 7.50e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 37.48  E-value: 7.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 106 CIASgeVVLLALMAYDRYVAICKPLHYFTIMNLKRCTGLVLTSWTIGFlhgishvvVLLQLPFCGPNKIDSFFCDMPLVI 185
Cdd:cd15063  84 CTAS--ILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSF--------VICFPPLVGWNDGKDGIMDYSGSS 153
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 186 KLACMdsqdlNTLMNGECGIL--AVTCFIL--LLISYTYILITVHQNSKTGASKALStctahITVVMIFFLPCFFIYVFP 261
Cdd:cd15063 154 SLPCT-----CELTNGRGYVIysALGSFYIpmLVMLFFYFRIYRAARMETKAAKTVA-----IIVGCFIFCWLPFFTVYL 223
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 22129111 262 LNITWLDKFLAVFYSVITPL------LNPVIYTLRNKEMKNA 297
Cdd:cd15063 224 VRAFCEDCIPPLLFSVFFWLgycnsaLNPCIYALFSRDFRFA 265
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
40-226 9.41e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 37.03  E-value: 9.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111  40 SGNIVIQILITTDPHLHSPMYFLLANLSFVDMLLSSNTTPRMIIDFFREKKTIsFAGCMSQIFFSHCIASGEVVLLAL-- 117
Cdd:cd15394  16 VGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWV-FGRFMCYFVFLMQPVTVYVSVFTLta 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129111 118 MAYDRYVAICKPLHyfTIMNLKRCTGLVLTSWtigflhgishvvvLLQLPFCGPNKIDSFFCDMPLVIKLAC---MDSQD 194
Cdd:cd15394  95 IAVDRYYVTVYPLR--RRISRRTCAYIVAAIW-------------LLSCGLALPAAAHTYYVEFKGLDFSICeefWFGQE 159
                       170       180       190
                ....*....|....*....|....*....|...
gi 22129111 195 LNTLMNGeCGILAVTCFI-LLLISYTYILITVH 226
Cdd:cd15394 160 KQRLAYA-CSTLLITYVLpLLAISLSYLRISVK 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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