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Conserved domains on  [gi|33238952|ref|NP_666745|]
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olfactory receptor family 2 subfamily AD member 1 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11607593)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
25-301 6.62e-178

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 492.67  E-value: 6.62e-178
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQN 264
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238952 265 TISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15434 241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
 
Name Accession Description Interval E-value
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
25-301 6.62e-178

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 492.67  E-value: 6.62e-178
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQN 264
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238952 265 TISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15434 241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
35-305 3.64e-40

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 141.87  E-value: 3.64e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952    35 YIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATECLL 114
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952   115 LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYSRV 194
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952   195 IEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYM--KPQNTISHEEGQ 272
Cdd:pfam13853 165 NNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPPLLQI 244
                         250       260       270
                  ....*....|....*....|....*....|...
gi 33238952   273 FFTLFYTIVTPSLNPLIYTLRNKDVKNAVKRIL 305
Cdd:pfam13853 245 MMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
25-301 6.62e-178

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 492.67  E-value: 6.62e-178
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQN 264
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33238952 265 TISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15434 241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
26-294 2.18e-156

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 437.83  E-value: 2.18e-156
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15947   2 PLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15947  82 WLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNT 265
Cdd:cd15947 162 KLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSS 241
                       250       260
                ....*....|....*....|....*....
gi 33238952 266 ISHEEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15947 242 YSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
30-301 3.30e-130

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 371.81  E-value: 3.30e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15432   6 VFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15432  86 TECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHE 269
Cdd:cd15432 166 VDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHD 245
                       250       260       270
                ....*....|....*....|....*....|..
gi 33238952 270 EGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15432 246 RGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
30-294 9.65e-129

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 367.58  E-value: 9.65e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd13954   6 LFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd13954  86 TECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHE 269
Cdd:cd13954 166 SDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYSSD 245
                       250       260
                ....*....|....*....|....*
gi 33238952 270 EGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd13954 246 LDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
29-301 2.48e-128

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 366.78  E-value: 2.48e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15225   5 VVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15225  85 GTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISH 268
Cdd:cd15225 165 CADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSP 244
                       250       260       270
                ....*....|....*....|....*....|...
gi 33238952 269 EEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15225 245 ETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
26-294 1.49e-126

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 362.36  E-value: 1.49e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15237   2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15237  82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNT 265
Cdd:cd15237 162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241
                       250       260
                ....*....|....*....|....*....
gi 33238952 266 ISHEEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15237 242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
29-300 5.72e-121

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 348.39  E-value: 5.72e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15421   5 SLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15421  85 GAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISH 268
Cdd:cd15421 165 CADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHSP 244
                       250       260       270
                ....*....|....*....|....*....|..
gi 33238952 269 EEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15421 245 EQDKVVSVFYTILTPMLNPLIYSLRNKEVLGA 276
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
26-301 2.23e-118

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 341.77  E-value: 2.23e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15433   2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15433  82 ALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNT 265
Cdd:cd15433 162 KLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHR 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238952 266 ISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15433 242 YSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
26-294 3.77e-118

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 340.74  E-value: 3.77e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCsLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15431  82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQALL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNT 265
Cdd:cd15431 161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240
                       250       260
                ....*....|....*....|....*....
gi 33238952 266 ISHEEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15431 241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
26-294 3.16e-117

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 338.71  E-value: 3.16e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15230   2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15230  82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNT 265
Cdd:cd15230 162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241
                       250       260
                ....*....|....*....|....*....
gi 33238952 266 ISHEEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15230 242 YSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
33-300 8.56e-113

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 327.82  E-value: 8.56e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  33 VFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATEC 112
Cdd:cd15429   9 VMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 113 LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYS 192
Cdd:cd15429  89 ILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 193 RVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHEEGQ 272
Cdd:cd15429 169 SLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSALQEK 248
                       250       260
                ....*....|....*....|....*...
gi 33238952 273 FFTLFYTIVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15429 249 MISLFYAVVTPMLNPLIYSLRNKEVKGA 276
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
29-300 2.18e-112

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 326.59  E-value: 2.18e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15420   5 GLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15420  85 HTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISH 268
Cdd:cd15420 165 CADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSA 244
                       250       260       270
                ....*....|....*....|....*....|..
gi 33238952 269 EEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15420 245 EQEKILSLFYSLFNPMLNPLIYSLRNKQVKGA 276
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
11-305 2.11e-110

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 322.39  E-value: 2.11e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  11 DFILLGFSSRPQLEHIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKK 90
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  91 SITYGGCVLQFFFALDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCG 170
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 171 HREVDNFFCEMPALIKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTL 250
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 33238952 251 FYGTLIYMYMKPQNTISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKRIL 305
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
24-301 3.60e-110

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 321.09  E-value: 3.60e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  24 EHIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFF 103
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 104 ALDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPA 183
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 184 LIKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQ 263
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238952 264 NTISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15235 241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
26-303 7.92e-108

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 315.03  E-value: 7.92e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15411   2 PLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15411  82 ALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNT 265
Cdd:cd15411 162 KLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSS 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238952 266 ISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKR 303
Cdd:cd15411 242 YSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
30-303 8.26e-108

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 314.97  E-value: 8.26e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVF-VFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15417   5 VLFlGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15417  85 LTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISH 268
Cdd:cd15417 165 CSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQ 244
                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238952 269 EEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKR 303
Cdd:cd15417 245 DQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-298 1.59e-107

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 314.64  E-value: 1.59e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  12 FILLGFSSRPQLEHIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKS 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  92 ITYGGCVLQFFFALDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGH 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 172 REVDNFFCEMPALIKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLF 251
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 33238952 252 YGTLIYMYMKPQNTISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVK 298
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
30-294 1.59e-107

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 314.04  E-value: 1.59e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15911   6 LFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15911  86 TECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHE 269
Cdd:cd15911 166 SDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSRD 245
                       250       260
                ....*....|....*....|....*
gi 33238952 270 EGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15911 246 LNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-305 4.40e-107

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 313.83  E-value: 4.40e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  12 FILLGFSSRPQLEHIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKS 91
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  92 ITYGGCVLQFFFALDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGH 171
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 172 REVDNFFCEMPALIKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLF 251
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238952 252 YGTLIYMYMKPQNTISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKRIL 305
Cdd:cd15410 241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
27-301 7.60e-107

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 312.66  E-value: 7.60e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALD 106
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIK 186
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 187 MACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTI 266
Cdd:cd15231 163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238952 267 SHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15231 243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-303 4.57e-105

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 308.60  E-value: 4.57e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  12 FILLGFSSRPQLEHIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKS 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  92 ITYGGCVLQFFFALDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGH 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 172 REVDNFFCEMPALIKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLF 251
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 33238952 252 YGTLIYMYMKPQNTISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKR 303
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
25-294 4.94e-104

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 305.06  E-value: 4.94e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15430   1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15430  81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQN 264
Cdd:cd15430 161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 33238952 265 TISHEEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15430 241 KNAQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
29-301 5.10e-104

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 305.51  E-value: 5.10e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15424   5 VVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15424  85 STECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISH 268
Cdd:cd15424 165 CADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTP 244
                       250       260       270
                ....*....|....*....|....*....|...
gi 33238952 269 EEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15424 245 DRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
30-303 1.08e-103

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 304.62  E-value: 1.08e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15419   6 LFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15419  86 TEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHE 269
Cdd:cd15419 166 SDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPE 245
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238952 270 EGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKR 303
Cdd:cd15419 246 QSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
26-294 2.07e-103

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 303.64  E-value: 2.07e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNT 265
Cdd:cd15912 162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241
                       250       260
                ....*....|....*....|....*....
gi 33238952 266 ISHEEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15912 242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
30-301 3.29e-103

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 303.36  E-value: 3.29e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15229   6 VFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15229  86 TEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHE 269
Cdd:cd15229 166 SDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSSV 245
                       250       260       270
                ....*....|....*....|....*....|..
gi 33238952 270 EGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15229 246 LDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
26-294 3.16e-102

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 300.52  E-value: 3.16e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVF-VFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15227   1 ILHFVLFlLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15227  81 IFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQN 264
Cdd:cd15227 161 LKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 33238952 265 TISHEEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15227 241 DSPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
25-294 2.37e-100

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 295.68  E-value: 2.37e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15918   1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQN 264
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 33238952 265 TISHEEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15918 241 SHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
26-294 2.40e-99

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 293.23  E-value: 2.40e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15946  82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNT 265
Cdd:cd15946 162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241
                       250       260
                ....*....|....*....|....*....
gi 33238952 266 ISHEEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15946 242 YSPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
26-301 8.74e-99

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 292.17  E-value: 8.74e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNT 265
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238952 266 ISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15234 242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
29-303 1.10e-97

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 289.30  E-value: 1.10e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15412   5 VLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15412  85 ITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISH 268
Cdd:cd15412 165 CSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESV 244
                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238952 269 EEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKR 303
Cdd:cd15412 245 EQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-305 2.13e-96

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 286.68  E-value: 2.13e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  12 FILLGFSSRPQLEHIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKS 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  92 ITYGGCVLQFFFALDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGH 171
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 172 REVDNFFCEMPALIKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLF 251
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238952 252 YGTLIYMYMKPQNTISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKRIL 305
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
26-303 1.25e-95

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 284.26  E-value: 1.25e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVF-VFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15416   1 IILFVLFlVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15416  81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQN 264
Cdd:cd15416 161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238952 265 TISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKR 303
Cdd:cd15416 241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
30-303 6.87e-94

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 279.68  E-value: 6.87e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15409   6 VFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSAT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15409  86 TECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHE 269
Cdd:cd15409 166 TDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALD 245
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238952 270 EGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKR 303
Cdd:cd15409 246 QDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
26-303 1.34e-93

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 278.82  E-value: 1.34e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15413   2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15413  82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNT 265
Cdd:cd15413 162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238952 266 ISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKR 303
Cdd:cd15413 242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
29-294 2.52e-92

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 275.32  E-value: 2.52e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15224   5 LLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15224  85 CTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISH 268
Cdd:cd15224 165 CTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSF 244
                       250       260
                ....*....|....*....|....*.
gi 33238952 269 EEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15224 245 DSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
30-301 1.60e-91

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 273.59  E-value: 1.60e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15428   6 LFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15428  86 TECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLAS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHE 269
Cdd:cd15428 166 TDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTSKE 245
                       250       260       270
                ....*....|....*....|....*....|..
gi 33238952 270 EGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15428 246 YDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
30-303 3.21e-91

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 272.75  E-value: 3.21e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15415   6 LFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15415  86 TEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHE 269
Cdd:cd15415 166 SDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLE 245
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238952 270 EGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKR 303
Cdd:cd15415 246 QEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
32-294 8.09e-91

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 271.44  E-value: 8.09e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  32 FVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATE 111
Cdd:cd15232   8 LFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSE 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 112 CLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVY 191
Cdd:cd15232  88 LLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 192 SRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHEEG 271
Cdd:cd15232 168 TSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPEKD 247
                       250       260
                ....*....|....*....|...
gi 33238952 272 QFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15232 248 KVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
32-294 1.85e-89

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 268.03  E-value: 1.85e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  32 FVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATE 111
Cdd:cd15913   8 SVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTE 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 112 CLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVY 191
Cdd:cd15913  88 CFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVP 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 192 SRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHEEG 271
Cdd:cd15913 168 APGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNSTGMQ 247
                       250       260
                ....*....|....*....|...
gi 33238952 272 QFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15913 248 KIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
33-306 4.56e-89

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 267.76  E-value: 4.56e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  33 VFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATEC 112
Cdd:cd15414   9 LVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 113 LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYS 192
Cdd:cd15414  89 FLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 193 RVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHEEGQ 272
Cdd:cd15414 169 QINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLDLDK 248
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238952 273 FFTLFYTIVTPSLNPLIYTLRNKDVKNAVKRILG 306
Cdd:cd15414 249 VVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIR 282
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
16-305 8.91e-89

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 266.93  E-value: 8.91e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  16 GFSSRPQLEHIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYG 95
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  96 GCVLQFFFALDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVD 175
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 176 NFFCEMPALIKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTL 255
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 33238952 256 IYMYMKPQNTISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKRIL 305
Cdd:cd15406 241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
25-294 1.86e-87

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 262.92  E-value: 1.86e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15939   1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAvMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQN 264
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVT 239
                       250       260       270
                ....*....|....*....|....*....|
gi 33238952 265 TISheEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15939 240 TFP--IDKVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
30-303 1.28e-86

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 261.20  E-value: 1.28e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVF-YIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15407   5 IIFTLiYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15407  85 TVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISH 268
Cdd:cd15407 165 CSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSM 244
                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238952 269 EEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKR 303
Cdd:cd15407 245 DTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
30-300 1.52e-86

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 260.83  E-value: 1.52e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15228   6 LFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15228  86 TECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQntISHE 269
Cdd:cd15228 166 ADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPT--PSPV 243
                       250       260       270
                ....*....|....*....|....*....|.
gi 33238952 270 EGQFFTLFYTIVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15228 244 LVTPVQIFNNVVTPMLNPLIYTLRNKEVKAA 274
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
30-303 6.89e-86

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 259.33  E-value: 6.89e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVF-YIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15418   6 VVFLLsYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15418  86 YSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISH 268
Cdd:cd15418 166 CDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTP 245
                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238952 269 EEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAVKR 303
Cdd:cd15418 246 DRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKK 280
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
30-294 1.01e-85

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 258.29  E-value: 1.01e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15226   6 FFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15226  86 SEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKiKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTIShe 269
Cdd:cd15226 166 TDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFP-- 242
                       250       260
                ....*....|....*....|....*
gi 33238952 270 EGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15226 243 VDKFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
29-294 2.37e-84

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 255.06  E-value: 2.37e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15940   5 MLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15940  85 CTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWrKVLNTCGSHLTVVTLFYGTLIYMYMKPqnTISH 268
Cdd:cd15940 165 CTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRR-KALSTCASHLTVVTLFFGPCIFIYTRP--STSF 241
                       250       260
                ....*....|....*....|....*.
gi 33238952 269 EEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15940 242 SEDKVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
26-294 1.47e-83

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 253.00  E-value: 1.47e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15915   2 FLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15915  82 FLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYA-VITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQN 264
Cdd:cd15915 162 KLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIyIISFLLLKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSS 241
                       250       260       270
                ....*....|....*....|....*....|
gi 33238952 265 TISHEEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15915 242 GDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
33-301 6.01e-83

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 251.57  E-value: 6.01e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  33 VFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATEC 112
Cdd:cd15405   9 GIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 113 LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYS 192
Cdd:cd15405  89 YVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTST 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 193 RVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHEEGQ 272
Cdd:cd15405 169 YVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNQGK 248
                       250       260
                ....*....|....*....|....*....
gi 33238952 273 FFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15405 249 VSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
30-294 2.43e-80

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 244.97  E-value: 2.43e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15914   6 LLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15914  86 TECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHE 269
Cdd:cd15914 166 TDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLD 245
                       250       260
                ....*....|....*....|....*
gi 33238952 270 EGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15914 246 YDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
30-301 2.56e-79

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 242.35  E-value: 2.56e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPK-KSITYGGCVLQFFFALDLG 108
Cdd:cd15916   6 IFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFHFLG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15916  86 STECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISH 268
Cdd:cd15916 166 CADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEAL 245
                       250       260       270
                ....*....|....*....|....*....|...
gi 33238952 269 EEgqFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15916 246 DG--VIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
35-301 5.97e-79

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 241.60  E-value: 5.97e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  35 YIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATECLL 114
Cdd:cd15236  11 YLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 115 LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYSRV 194
Cdd:cd15236  91 LAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 195 IEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHEEGQFF 274
Cdd:cd15236 171 NELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKDIVA 250
                       250       260
                ....*....|....*....|....*..
gi 33238952 275 TLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15236 251 SVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
30-294 2.61e-78

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 239.54  E-value: 2.61e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15936   6 VFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15936  86 AEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVItqaVMKIKSATR--WRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTIS 267
Cdd:cd15936 166 TDTFLLELLMVSNSGLVTLLIFFILLISYTVI---LVKIRTHVTegKRKALSTCASQITVVTLIFVPCIYIYARPFQTFP 242
                       250       260
                ....*....|....*....|....*..
gi 33238952 268 HEegQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15936 243 MD--KAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
26-300 4.04e-76

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 234.30  E-value: 4.04e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15233   2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALI 185
Cdd:cd15233  82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 KMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNT 265
Cdd:cd15233 162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 33238952 266 ISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15233 242 YSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGA 276
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
29-294 2.20e-72

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 224.37  E-value: 2.20e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15938   5 ALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMA 188
Cdd:cd15938  85 AAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFLLVPLSLILISYAVItqaVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISH 268
Cdd:cd15938 165 CTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPV 241
                       250       260
                ....*....|....*....|....*.
gi 33238952 269 EegQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15938 242 D--KHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
33-301 1.90e-70

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 219.61  E-value: 1.90e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  33 VFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATEC 112
Cdd:cd15942   9 VVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 113 LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYS 192
Cdd:cd15942  89 FLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 193 RVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNtiSHEEGQ 272
Cdd:cd15942 169 AFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS--QDPLDG 246
                       250       260
                ....*....|....*....|....*....
gi 33238952 273 FFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15942 247 VVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
30-294 2.39e-70

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 219.22  E-value: 2.39e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGA 109
Cdd:cd15937   6 LFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMAC 189
Cdd:cd15937  86 AEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 190 VYSRVIEIVVFTLGVIFLLVPLSLILISYAVITqAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHE 269
Cdd:cd15937 166 TNTYTVELLMFSNSGLVILLCFLLLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSFPMD 244
                       250       260
                ....*....|....*....|....*
gi 33238952 270 egQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15937 245 --KVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
26-294 6.88e-69

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 215.40  E-value: 6.88e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQL-HTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15935   2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15935  82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITqAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQN 264
Cdd:cd15935 162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIIL-TTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 33238952 265 TISHEegQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd15935 241 SSSVD--KVASVFYTLITPALNPLIYTLRN 268
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
35-301 1.97e-68

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 214.71  E-value: 1.97e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  35 YIVTLVGNTTIILVSYLDSQLHT-PMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPK-KSITYGGCVLQFFFALDLGATEC 112
Cdd:cd15941  11 YLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAFHFLASTEC 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 113 LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYS 192
Cdd:cd15941  91 FLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADT 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 193 RVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNtiSHEEGQ 272
Cdd:cd15941 171 TINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS--SQAGAG 248
                       250       260
                ....*....|....*....|....*....
gi 33238952 273 FFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15941 249 APAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
25-301 1.43e-60

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 194.43  E-value: 1.43e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15223   1 HWLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15223  81 HFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYM--KP 262
Cdd:cd15223 161 VSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRF 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238952 263 QNTISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15223 241 GKTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
35-297 1.90e-57

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 186.47  E-value: 1.90e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  35 YIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATECLL 114
Cdd:cd15950  11 YVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGV 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 115 LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYSRV 194
Cdd:cd15950  91 LLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADPRP 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 195 IEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFY--GTL-IYMYMKPQNTISHEEg 271
Cdd:cd15950 171 SSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYipGLLsIYTQRFGQGVPPHTQ- 249
                       250       260
                ....*....|....*....|....*.
gi 33238952 272 QFFTLFYTIVTPSLNPLIYTLRNKDV 297
Cdd:cd15950 250 VLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
25-295 1.27e-56

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 184.41  E-value: 1.27e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15917   1 IWLSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15917  81 HSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMkpqn 264
Cdd:cd15917 161 VKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFL---- 236
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238952 265 tiSHEEGQ--------FFTLFYTIVTPSLNPLIYTLRNK 295
Cdd:cd15917 237 --THRFGHhvpphvhiLLANLYLLLPPMLNPIVYGVRTK 273
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
27-297 6.52e-55

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 179.88  E-value: 6.52e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALD 106
Cdd:cd15952   3 IGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVMAYDRYAAVCQPLHYTVImhpvLCQKMVLSAWLGGLGSALILCS----LTLKLPRCGHREVDNFFCEMP 182
Cdd:cd15952  83 FTGMESAVLVAMAFDRYVAICNPLRYTTI----LTNKVISVIALGIVLRPLLLVLpfvfLILRLPFCGHNIIPHTYCEHM 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 183 ALIKMACVYSRVieIVVFTLGVI-FLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMK 261
Cdd:cd15952 159 GIAKLACASIRI--NIIYGLFAIsVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLT 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 33238952 262 PQ--NTISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDV 297
Cdd:cd15952 237 HRfgHNIPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
27-295 6.33e-54

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 177.10  E-value: 6.33e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALD 106
Cdd:cd15221   3 ISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIK 186
Cdd:cd15221  83 VFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIAR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 187 MACVYSRVieIVVFTLGVIFLLVPLSLILI--SYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQ- 263
Cdd:cd15221 163 LACADITV--NIWYGLTVALLTVGLDVVLIavSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRf 240
                       250       260       270
                ....*....|....*....|....*....|...
gi 33238952 264 -NTISHEEGQFFTLFYTIVTPSLNPLIYTLRNK 295
Cdd:cd15221 241 gRHIPRHVHILLANLYVLVPPMLNPIVYGVKTK 273
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
27-295 7.60e-51

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 169.37  E-value: 7.60e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALD 106
Cdd:cd15953   3 ISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIK 186
Cdd:cd15953  83 LSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 187 MACVYSRVIEIvvFTLGVIFLLVPLSLILI--SYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYmymkpqN 264
Cdd:cd15953 163 LACGDTTINRI--YGLVVALLVVGLDLLLIalSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALF------S 234
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238952 265 TISHEEGQ--------FFTLFYTIVTPSLNPLIYTLRNK 295
Cdd:cd15953 235 FLTHRFGQgiaphihiILANLYLLVPPMLNPIIYGVKTK 273
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
35-297 1.37e-47

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 160.98  E-value: 1.37e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  35 YIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATECLL 114
Cdd:cd15951  11 YAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGI 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 115 LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYSRV 194
Cdd:cd15951  91 FVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADTRV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 195 IEivVFTLGVIFLLVPLSLILI--SYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMkpqntiSHEEGQ 272
Cdd:cd15951 171 SR--AYGLSVAFLVGGLDVIFIavSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFL------THRFGH 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 33238952 273 --------FFTLFYTIVTPSLNPLIYTLRNKDV 297
Cdd:cd15951 243 nvpphvhiLIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
25-295 2.00e-47

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 160.36  E-value: 2.00e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15222   1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEI-----VVFTLGVIFLlvplsLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLI--- 256
Cdd:cd15222 161 MKLACSDTRVNSIyglfvVLSTMGLDSL-----LILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIgls 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 33238952 257 --YMYMKPQNTISHeegqffTLF---YTIVTPSLNPLIYTLRNK 295
Cdd:cd15222 236 mvHRFGKHASPLVH------VLManvYLLVPPVLNPIIYSVKTK 273
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
27-297 2.83e-40

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 141.93  E-value: 2.83e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALD 106
Cdd:cd15956   3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIK 186
Cdd:cd15956  83 FSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 187 MACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFY--GTLIYMYMKPQN 264
Cdd:cd15956 163 LACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYipGLLSVLMHRFGH 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 33238952 265 TISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDV 297
Cdd:cd15956 243 SVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
35-305 3.64e-40

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 141.87  E-value: 3.64e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952    35 YIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATECLL 114
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952   115 LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYSRV 194
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952   195 IEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYM--KPQNTISHEEGQ 272
Cdd:pfam13853 165 NNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPPLLQI 244
                         250       260       270
                  ....*....|....*....|....*....|...
gi 33238952   273 FFTLFYTIVTPSLNPLIYTLRNKDVKNAVKRIL 305
Cdd:pfam13853 245 MMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
35-298 1.33e-39

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 140.04  E-value: 1.33e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  35 YIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATECLL 114
Cdd:cd15948  12 FTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAV 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 115 LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYSRV 194
Cdd:cd15948  92 LLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDTRF 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 195 IEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIY---MYMKPQNTISHEEg 271
Cdd:cd15948 172 NNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLsstMHRFARHVAPHVH- 250
                       250       260
                ....*....|....*....|....*..
gi 33238952 272 QFFTLFYTIVTPSLNPLIYTLRNKDVK 298
Cdd:cd15948 251 ILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
10-298 1.68e-38

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 137.60  E-value: 1.68e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  10 TDFILLGFssrPQLE--HIISAVVFVF-YIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLW 86
Cdd:cd15949   2 STFILLGI---PGLEplHVWISIPFCSmYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFW 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  87 GPKKSITYGGCVLQFFFALDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKL 166
Cdd:cd15949  79 FSSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 167 PRCGHREVDNFFCEMPALIKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLT 246
Cdd:cd15949 159 PWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVC 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 33238952 247 VVTLFY-----GTLIYMYMKpqnTISHEEGQFFTLFYTIVTPSLNPLIYTLRNKDVK 298
Cdd:cd15949 239 AILAFYvpiavSSLIHRFGQ---NVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
25-297 1.61e-34

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 126.81  E-value: 1.61e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15955   1 HWIGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLggLGSALILCSLTLKLPRCGHRE---VDNFFCEM 181
Cdd:cd15955  81 HTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVV--RAVVLIIPCPLLIKLRLHHFRstvISHSYCEH 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 182 PALIKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMk 261
Cdd:cd15955 159 MAVVKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFF- 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 33238952 262 pqntiSHEEGQ--------FFTLFYTIVTPSLNPLIYTLRNKDV 297
Cdd:cd15955 238 -----AHRFGHhvapyvhiLLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
27-297 1.90e-33

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 124.17  E-value: 1.90e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALD 106
Cdd:cd15954   3 ISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIK 186
Cdd:cd15954  83 FTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 187 MACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTI 266
Cdd:cd15954 163 LACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFGG 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238952 267 SHEEGQFFTL---FYTIVTPSLNPLIYTLRNKDV 297
Cdd:cd15954 243 HHITPHIHIImanLYLLLPPMMNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
41-290 6.99e-33

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 122.02  E-value: 6.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952    41 GNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLV-NLWGPKKSITYGGCVLQFFFALDLGATECLLLAVMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVyYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952   120 YDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLklpRCGHREVDNFFCEMPALIKMACVYSRVIEIVV 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGW---TLTVPEGNVTVCFIDFPEDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952   200 FtlgviFLLVPLSLILISYAVITQAVMKIKSA-------TRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHEEGQ 272
Cdd:pfam00001 158 L-----GFLLPLLVILVCYTLIIRTLRKSASKqkssertQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232
                         250       260
                  ....*....|....*....|....
gi 33238952   273 FFTLFYTI------VTPSLNPLIY 290
Cdd:pfam00001 233 LLDKALSVtlwlayVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
27-294 1.27e-24

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 100.44  E-value: 1.27e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALD 106
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGglgsALILCSLTLklprCGHREVDNFFCEMPALIK 186
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLL----SLLLALPPL----LGWGVYDYGGYCCCCLCW 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 187 MACVYSRVIEIVVFtlgVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSH-----------LTVVTLFY--- 252
Cdd:cd00637 153 PDLTLSKAYTIFLF---VLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRrrrerkvtktlLIVVVVFLlcw 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 33238952 253 ----GTLIYMYMKPQNTISHEEGQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd00637 230 lpyfILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
26-300 5.41e-15

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 73.37  E-value: 5.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGglgsALILCSLTLKLPRCGHREVDNFFCempali 185
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVY----SLLISLPPLVGWRDETQPSVVDCE------ 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 186 kmaCVYSRVIEIVVFTLGVIFLLvPLSLILISYAVITQAVMKIKSATRwrkvlntcgsHLTVVTL--------FYGTLIY 257
Cdd:cd14967 151 ---CEFTPNKIYVLVSSVISFFI-PLLIMIVLYARIFRVARRELKAAK----------TLAIIVGafllcwlpFFIIYLV 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 33238952 258 MYMKPQNTISHEegqFFTLFYTI--VTPSLNPLIYTLRNKDVKNA 300
Cdd:cd14967 217 SAFCPPDCVPPI---LYAVFFWLgyLNSALNPIIYALFNRDFRRA 258
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
26-300 1.76e-11

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 63.14  E-value: 1.76e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVP-----QMLVNLWgpkksiTYGGCVLQ 100
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfsilhEMTGGYW------LFGRDWCD 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 101 FFFALD-LGATECLL-LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLgglgsalilCSLTLKLPRCGH-REVDNf 177
Cdd:cd15067  75 VWHSFDvLASTASILnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI---------CSALISFPAIAWwRAVDP- 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 178 fcemPALIKMACVYSRVIEIVVFTLGVIFLlVPLSLILISYAVItqavmkIKSATRWRKVLNTCGSHLTVVTL----FYG 253
Cdd:cd15067 145 ----GPSPPNQCLFTDDSGYLIFSSCVSFY-IPLVVMLFTYYRI------YRAAAKEQKAAKTLGIVMGVFILcwlpFFV 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238952 254 TLIYMYMKPQNTISHEEgqfftLFYTIVT------PSLNPLIYTLRNKDVKNA 300
Cdd:cd15067 214 TNILIGFCPSNCVSNPD-----ILFPLVTwlgyinSGMNPIIYACSSRDFRRA 261
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
25-301 2.57e-11

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 62.99  E-value: 2.57e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCqKMVLSAWLGGLGSALilcsltlkLPRCG----HREVDNFFCE 180
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRAL-ILIAFIWLYGLFWAL--------PPLFGwssyVPEGGGTSCS 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 181 MPALIKMACVYSRVIEIVVFtlgviFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGS------HLTVVTLF--- 251
Cdd:cd14969 152 VDWYSKDPNSLSYIVSLFVF-----CFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRtkkaekKVAKMVLVmiv 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33238952 252 --------YGTL-IYMYMKPQNTISheegqffTLFYTIvtPSL--------NPLIYTLRNKDVKNAV 301
Cdd:cd14969 227 afliawtpYAVVsLYVSFGGESTIP-------PLLATI--PALfaksstiyNPIIYVFMNKQFRRAL 284
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
26-300 2.00e-10

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 60.04  E-value: 2.00e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVP----QMLVNLWgpkksiTYGGCVLQF 101
Cdd:cd15064   2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPlsavYELTGRW------ILGQVLCDI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 102 FFALDLGATEC--LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWlgglgsaliLCSLTLKLP-----RCGHREV 174
Cdd:cd15064  76 WISLDVTCCTAsiLHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVW---------TLSICISLPplfgwRTPDSED 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 175 DNffcempalikmACVYSRVIEIVVF-TLGVIFllVPLSLILISYAVITQAvmkiksATRWRKVLNTCGSHLTVVTL--- 250
Cdd:cd15064 147 PS-----------ECLISQDIGYTIFsTFGAFY--IPLLLMLILYWKIYRA------AARERKAAKTLGIILGAFIVcwl 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 33238952 251 -FYGTLIYMYMKPQNTISHEEGQFFT-LFYtiVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15064 208 pFFLVALIVPLCSHCWIPLALKSFFLwLGY--FNSLINPLIYTFFNKDFRKA 257
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
22-301 1.79e-09

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 57.24  E-value: 1.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  22 QLEHIISAVVFvfyIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTT-SIVPQMlvnLWgpkkSIT---YGGC 97
Cdd:cd15196   1 KVEIAVLATIL---VLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALfNVLPQL---IW----DITyrfYGGD 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  98 VL----QFFFALDLGATECLLLAvMAYDRYAAVCQPL-HYTVIMHPVLCqkMVLSAWLGglgsALILCSLTL---KLPRC 169
Cdd:cd15196  71 LLcrlvKYLQVVGMYASSYVLVA-TAIDRYIAICHPLsSHRWTSRRVHL--MVAIAWVL----SLLLSIPQLfifSYQEV 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 170 GHREVDNFFCEMPALIKMAcvYSRVIEIVVFtlgviflLVPLSLILISYAVITQAVmkiksatrWRKVLNTCGSHLTVVT 249
Cdd:cd15196 144 GSGVYDCWATFEPPWGLRA--YITWFTVAVF-------VVPLIILAFCYGRICYVV--------WRAKIKTVKLTLVVVA 206
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 33238952 250 L-------FYGTLIYMYMKPQntiSHEEGQFFTlfYTIVTPSL----NPLIYTLRNKDVKNAV 301
Cdd:cd15196 207 CyivcwtpFFVVQMWAAWDPT---APIEGPAFV--IIMLLASLnsctNPWIYLAFSGNLRRAL 264
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
26-221 3.68e-08

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 53.90  E-value: 3.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSIT-YGGCVLQFFFA 104
Cdd:cd14979   2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFgDGGCKLYYFLF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLtlklprcgHREVDNFFCE---M 181
Cdd:cd14979  82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFL--------MGIQYLNGPLpgpV 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 33238952 182 PALIKMACVYSRVIEIVVF-TLGVIFLLVPLSLILISYAVI 221
Cdd:cd14979 154 PDSAVCTLVVDRSTFKYVFqVSTFIFFVLPMFVISILYFRI 194
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
26-300 1.16e-07

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 51.87  E-value: 1.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLwgPKKSITYGGCVLQFFFAL 105
Cdd:cd15334   2 LISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYI--VKETWIMGQVVCDIWLSV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATEC--LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLgsalilcsltlklprcghrevdnfFCEMPA 183
Cdd:cd15334  80 DITCCTCsiLHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISI------------------------FISMPP 135
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 184 LIKMACVYSRVIEI------VVFTLGVIF--LLVPLSLILISYAVITQAvmkiksATRWRKVLNTCGSHLTVVTL----F 251
Cdd:cd15334 136 LFWRHQTTSREDECiikhdhIVFTIYSTFgaFYIPLALILILYYKIYRA------ATRERKAATTLGLILGAFVIcwlpF 209
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 33238952 252 YGTLIYMYMKPQNTISHEEGQFFTlFYTIVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15334 210 FVKEVIVNTCDSCYISEEMSNFLT-WLGYINSLINPLIYTIFNEDFKKA 257
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
36-300 1.70e-07

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 51.66  E-value: 1.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  36 IVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCvlQFFFALDLGATEC--L 113
Cdd:cd15050  12 LITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVC--LFWLSMDYVASTAsiF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 114 LLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLgglgsalilCSLTLKLPRCGHREVDNFFCEMPALIKMACVYSR 193
Cdd:cd15050  90 SLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWL---------LSFLWVIPILGWHHFARGGERVVLEDKCETDFHD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 194 VIEIVVFTLGVIFLLvPLSLILISYAVITQAVMKIKSATRWRKVLNTCgshLTVVTLFYGTLiYMYMKPQNTISHEEGQF 273
Cdd:cd15050 161 VTWFKVLTAILNFYI-PSLLMLWFYAKIFKAVNRERKAAKQLGFIMAA---FILCWIPYFIL-FMVIAFCKNCCNENLHM 235
                       250       260
                ....*....|....*....|....*..
gi 33238952 274 FTLFYTIVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15050 236 FTIWLGYINSTLNPFIYPLCNENFKKT 262
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
26-225 1.72e-07

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 51.53  E-value: 1.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSI---VPQMLVNLWgpkksiTYGGCVLQFF 102
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLpflATSYLLGYW------PFGEVMCKIV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 103 FALDL--GATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSAL--ILCSLTLKLprcghrEVDNFF 178
Cdd:cd14970  76 LSVDAynMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLpvIIFARTLQE------EGGTIS 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 33238952 179 C--EMPALIKmacVYSRVIEIVVFTLGVIfllVPLSLILISYAVITQAV 225
Cdd:cd14970 150 CnlQWPDPPD---YWGRVFTIYTFVLGFA---VPLLVITVCYSLIIRRL 192
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
26-237 2.08e-07

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 51.29  E-value: 2.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFyIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15012   2 FIILYTLVF-CCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWL--GGLGSALILCSLTLKLPRCGHREVDNFFCEMPA 183
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLtsAVYNTPYFVFSQTVEILVTQDGQEEEICVLDRE 160
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238952 184 LIKMacvysRVIEIVVFtlgVIFLLVPLSLILISYAVITQAVMKIKSATRWRKV 237
Cdd:cd15012 161 MFNS-----KLYDTINF---IVWYLIPLLIMTVLYSKISIVLWKSSSIEARRKV 206
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
29-153 2.65e-07

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 51.22  E-value: 2.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLC-----YTTSIVPQMLVNLWGPK---KSITYGGCVLQ 100
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVvafftVLTQIIWEATGEWVAGDvlcRIVKYLQVVGL 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238952 101 FffaldlgaTECLLLAVMAYDRYAAVCQPLhyTVIMHPVLCQKMVLSAWLGGL 153
Cdd:cd14986  85 F--------ASTYILVSMSLDRYQAIVKPM--SSLKPRKRARLMIVVAWVLSF 127
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
33-156 4.53e-07

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 50.35  E-value: 4.53e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  33 VFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATEC 112
Cdd:cd15074   9 VIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 33238952 113 LLLAVMAYDRYAAVCQPLHYTVIMHPVLCqKMVLSAWLGGLGSA 156
Cdd:cd15074  89 NTLTAISIYRYLKICHPPYGPKLSRRHVC-IVIVAIWLYALFWA 131
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
30-221 5.44e-07

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 50.02  E-value: 5.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVT-LVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKK-SITYGGCVLQFFFALDL 107
Cdd:cd15134   5 IIYGIIFVTgVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPwVFGEVFCKLRAFLSEMS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 108 GATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLT----LKLPRCGHREV-DNFFCEMP 182
Cdd:cd15134  85 SYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTrivyLEYPPTSGEALeESAFCAML 164
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 33238952 183 alikmacvYSRVIEIVVFTL-GVIFLLVPLSLILISYAVI 221
Cdd:cd15134 165 --------NEIPPITPVFQLsTFLFFIIPMIAIIVLYVLI 196
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
26-301 5.49e-07

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 50.03  E-value: 5.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVN-LWGpkkSITYGGCVLQFFFA 104
Cdd:cd15059   2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNeLMG---YWYFGSVWCEIWLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LD-LGATECLL-LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWlggLGSALIlcSLTlklPRCGHREVDNFFCEMP 182
Cdd:cd15059  79 LDvLFCTASIVnLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVW---IISAVI--SLP---PLFGWKDEQPWHGAEP 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 183 alikmACVYSRVIEIVVFTLGVIFlLVPLSLILISYAVITQAVmkIKSATRWRKVLNTCGSHLTVVTL-FYGTLIYMYMK 261
Cdd:cd15059 151 -----QCELSDDPGYVLFSSIGSF-YIPLLIMIIVYARIYRAA--KRKERRFTLVLGVVMGAFVLCWLpFFFTYPLVVVC 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33238952 262 PQNTISHEEGQFFT-LFYtiVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15059 223 KTCGVPELLFKFFFwLGY--CNSALNPVIYTIFNKDFRRAF 261
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
26-130 1.54e-06

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 48.62  E-value: 1.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDL-CYTTSIVPQMLVNLWGpKKSITYGGCVLQFFFA 104
Cdd:cd15075   2 ILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLgTTVFGGLLSVVTNAVG-YFNLGRVGCVLEGFAV 80
                        90       100
                ....*....|....*....|....*.
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPL 130
Cdd:cd15075  81 AFFGIAALCTVAVIAVDRLFVVCKPL 106
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
32-290 2.03e-06

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 48.42  E-value: 2.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  32 FVFyIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSiVPQMLVNL----WGPKKSITYGGCVLQFFFALDL 107
Cdd:cd14982   9 LIF-ILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLT-LPFRIYYYlnggWWPFGDFLCRLTGLLFYINMYG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 108 GateCLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAW-LGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAlik 186
Cdd:cd14982  87 S---ILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWiLVLVASVPLLLLRSTIAKENNSTTCFEFLSEWLA--- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 187 macvysRVIEIVVFTLGVIFLLvPLSLILISYAVITQAVMKIKSAT----RWRKVLNTCGSHLTVVTLFYG----TLIYM 258
Cdd:cd14982 161 ------SAAPIVLIALVVGFLI-PLLIILVCYSLIIRALRRRSKQSqksvRKRKALRMILIVLAVFLVCFLpyhvTRILY 233
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 33238952 259 YMKPQNTISHEEGQ---FFTLFYTIVTPSLN----PLIY 290
Cdd:cd14982 234 LLVRLSFIADCSARnslYKAYRITLCLASLNscldPLIY 272
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
26-298 2.66e-06

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 48.03  E-value: 2.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQ---MLVNLWgpkksiTYGGCVLQFF 102
Cdd:cd15091   2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQstvYLMNSW------PFGDVLCKIV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 103 FALDLGA--TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLggLGSALILCSLTLKLPRCgHREVDNFFCE 180
Cdd:cd15091  76 ISIDYYNmfTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWL--LSSSVGISAIVLGGTKV-REDVDSTECS 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 181 MPALIKMACVYSRVIEIVVFtlgVIFLLVPLSLILISYAVITQAVMKIK----SATRWRKVLNTCGSHLTVVTLFY---- 252
Cdd:cd15091 153 LQFPDDDYSWWDTFMKICVF---IFAFVIPVLIIIVCYTLMILRLKSVRllsgSREKDRNLRRITRLVLVVVAVFVvcwt 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 33238952 253 GTLIYMYMKPQNTISHEEGQFFTLFYTI----VTPSLNPLIYTLRNKDVK 298
Cdd:cd15091 230 PIHIFILVEALGSVSHSTAAVSSYYFCIalgyTNSSLNPILYAFLDENFK 279
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
26-296 3.67e-06

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 47.27  E-value: 3.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNL----WgpkksiTYGGCVLQF 101
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYElsgyW------PFGEILCDV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 102 FFALDLgaTEC----LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWlggLGSALILCSltlklPRCGHREVDNf 177
Cdd:cd15329  76 WISFDV--LLCtasiLNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVW---LLSALISIP-----PLFGWKNKVN- 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 178 fcempalIKMACVYSRVIEIVVF-TLGVIFLlvPLSLILISYAVITQAvmkiksATRWRKVLNTCGSHLTVVTL-----F 251
Cdd:cd15329 145 -------DPGVCQVSQDFGYQIYaTFGAFYI--PLIVMLVLYYKIYRA------AKSERKAIKTLGIIMGAFTLcwlpfF 209
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 33238952 252 YGTLI--YMYMKPQNTISHEEGQFFtLFYTIVTPSLNPLIYTLRNKD 296
Cdd:cd15329 210 ILALLrpFLKPIKCSCIPLWLSRLF-LWLGYANSFLNPIIYAKFNRE 255
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
26-150 6.05e-06

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 47.10  E-value: 6.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVP----QMLVNLWgpkksiTYGGCVLQF 101
Cdd:cd15056   2 VLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPfgaiELVNNRW------IYGETFCLV 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 33238952 102 FFALDLGATEC--LLLAVMAYDRYAAVC-QPLHYTviMHPVLCQKMVLSAWL 150
Cdd:cd15056  76 RTSLDVLLTTAsiMHLCCIALDRYYAICcQPLVYK--MTPLRVAVMLGGCWV 125
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
27-233 8.22e-06

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 46.56  E-value: 8.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLcyttsIVPQMLVNLWGPKKSITY---GGCVLQFFF 103
Cdd:cd15300   3 IAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADL-----IIGIFSMNLYTSYILMGYwalGSLACDLWL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 104 ALDLGATEC--LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGG--LGSALILCSLTLklprCGHREVDNFFC 179
Cdd:cd15300  78 ALDYVASNAsvMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISfiLWAPPILCWQYF----VGKRTVPEREC 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238952 180 EMPALIKmacvysrviEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATR 233
Cdd:cd15300 154 QIQFLSE---------PTITFGTAIAAFYIPVSVMTILYCRIYKETIKERKAAQ 198
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
26-161 8.83e-06

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 46.56  E-value: 8.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15083   2 VLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGG 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLgglgSALILCS 161
Cdd:cd15083  82 LFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWL----YSLLWVL 133
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
26-300 1.00e-05

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 46.07  E-value: 1.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPqmLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15335   2 LIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMP--LSITYIVMDTWTLGYFICEIWLSV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATEC--LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWlgglgsaliLCSLTLKLPRCGHREVDNFFCEMPA 183
Cdd:cd15335  80 DMTCCTCsiLHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVW---------TISIFISIPPLFWRNHHDANIPSQC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 184 LIKmacvYSRVIEIVVFTLGVIFllVPLSLILISYAVITQAvmkiksATRWRKVLNTCGSHLTVVTL----FYGTLIYMY 259
Cdd:cd15335 151 IIQ----HDHVIYTIYSTFGAFY--IPLTLILILYYRIYHA------ASRERKAARILGLILGAFILswlpFFIKELIVG 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 33238952 260 MKPQnTISHEEGQFFTlFYTIVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15335 219 LSVM-TVSPEVADFLT-WLGYVNSLVNPLLYTSFNEDFKLA 257
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
30-300 1.12e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 46.08  E-value: 1.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVP-QMLVNLWGPKKSITYGGCVLQFFFALDLG 108
Cdd:cd15304   6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGsalilcsLTLKLPRCGHREVDNFFCEmpalikMA 188
Cdd:cd15304  86 TASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVG-------ISMPIPVFGLQDDSKVFKE------GS 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 189 CVYSRVIEIVVFTLGVIFllVPLSLILISYAVITQAVMK-IKSATRWRKVLNTCGSHLTVVTL-FYGTLIYMYMKPQNTI 266
Cdd:cd15304 153 CLLADENFVLIGSFVAFF--IPLTIMVITYFLTIKSLQQsISNEQKASKVLGIVFFLFVVMWCpFFITNVMAVICKESCN 230
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 33238952 267 SHEEGQFFTLFYTI--VTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15304 231 EVVIGGLLNVFVWIgyLSSAVNPLVYTLFNKTYRSA 266
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
26-157 1.47e-05

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 45.92  E-value: 1.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVP----------QMLVNLWgpkksityg 95
Cdd:cd14971   2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPftatiyplpgWVFGDFM--------- 72
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 33238952  96 gC-VLQFFFALDLGATeCLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSAL 157
Cdd:cd14971  73 -CkFVHYFQQVSMHAS-IFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAA 133
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
27-301 1.72e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 45.56  E-value: 1.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLcYTTSIVPQMLVNLWGPKkSITYGGCVLQFFFALD 106
Cdd:cd15928   3 VTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLWRYR-PWRFGDLLCRLMYFFS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVMAY--DRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15928  81 ETCTYASILHITALsvERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTLF--------YGTLI 256
Cdd:cd15928 161 SSGLLSVMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRDNNHRQTVRMLAVIVLAFvlcwlpfhVGRVI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 33238952 257 YMYMKPQNTISHEEGQFFT-----LFYtiVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15928 241 FNHSRASTKHLHYVSQYFNlvsfvLFY--LSAAINPILYNLMSKRYRYAV 288
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
26-216 2.30e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 45.32  E-value: 2.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVsYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNL------WGPKKSITYGgCVL 99
Cdd:cd14978   2 LYGYVLPVICIFGIIGNILNLVV-LTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYiadyssSFLSYFYAYF-LPY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 100 QFFFALDLGATECLLLAVMAYDRYAAVCQPLHytvimhpvlCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREV-DNFF 178
Cdd:cd14978  80 IYPLANTFQTASVWLTVALTVERYIAVCHPLK---------ARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVvECEN 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 33238952 179 CEMPALIKMACVYSRVIE-----IVVFTLGVIFLLVPLSLILI 216
Cdd:cd14978 151 CNNNSYYYVIPTLLRQNEtyllkYYFWLYAIFVVLLPFILLLI 193
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
26-221 2.68e-05

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 44.97  E-value: 2.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKksITYGG---CVLQFF 102
Cdd:cd14997   2 LVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWARE--PWLLGefmCKLVPF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 103 FALDLGATECLLLAVMAYDRYAAVCQPLH--YTVIMHPVLCqkMVLSAWlgglGSALILCSLTLKLPrcgHREVDNFF-- 178
Cdd:cd14997  80 VELTVAHASVLTILAISFERYYAICHPLQakYVCTKRRALV--IIALIW----LLALLTSSPVLFIT---EFKEEDFNdg 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 33238952 179 -----CEMPALIKMACVYsrvieivVFTLGVIFLLVPLSLILISYAVI 221
Cdd:cd14997 151 tpvavCRTPADTFWKVAY-------ILSTIVVFFVVPLAILSGLYSVI 191
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
36-150 2.73e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 45.04  E-value: 2.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  36 IVTLVGNTTIIL-VSYLdSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVnlwgpkKSIT---YGG---CVLQFFFALDLG 108
Cdd:cd15312  12 LLTVFGNLMVIIsISHF-KQLHSPTNFLILSLAITDFLLGFLVMPYSMV------RSVEscwYFGdlfCKIHSSLDMMLS 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 33238952 109 ATECLLLAVMAYDRYAAVCQPLHYTV-IMHPVLCQKMVLSaWL 150
Cdd:cd15312  85 TTSIFHLCFIAVDRYYAVCDPLHYRTkITTPVIKVFLVIS-WS 126
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
26-301 3.47e-05

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 44.34  E-value: 3.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKksITYGGCVLQFFFAL 105
Cdd:cd15060   2 VTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGK--WLFGIHLCQMWLTC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 D-LGATECLL-LAVMAYDRYAAVCQPLHYTvimhpvlcQKMVLSAWLGGLGSALILCSLTLKLPRCGHRE-VDNFFCEMP 182
Cdd:cd15060  80 DiLCCTASILnLCAIALDRYWAIHDPINYA--------QKRTLKRVLLMIVVVWALSALISVPPLIGWNDwPENFTETTP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 183 alikmaCVYSRVIEIVVFT-LGVIFllVPLSLILISYAVITQAVMKIKSATRwrkvlnTCGSHLTVVTLFYGTLIYMYMK 261
Cdd:cd15060 152 ------CTLTEEKGYVIYSsSGSFF--IPLLIMTIVYVKIFIATSKERRAAR------TLGIIMGVFVVCWLPFFLMYVI 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 33238952 262 ----PQNTISHEEGQFFTlFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15060 218 lpfcETCSPSAKVVNFIT-WLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
26-300 3.86e-05

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 44.20  E-value: 3.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQ----MLVNLWgpkksiTYGGCVLQF 101
Cdd:cd15330   2 ITSLFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMaalyQVLNKW------TLGQVTCDL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 102 FFALD-LGATECLL-LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALIlcsltlklPRCGHREVDNffc 179
Cdd:cd15330  76 FIALDvLCCTSSILhLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIP--------PMLGWRTPED--- 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 180 empALIKMACVYSRVIEIVVF-TLGVIFllVPLSLILISYAVItqavmkIKSATRWRKVLNTCGSHLTVVTL-----FYG 253
Cdd:cd15330 145 ---RSDPDACTISKDPGYTIYsTFGAFY--IPLILMLVLYGRI------FKAAARERKTVKTLGIIMGTFILcwlpfFIV 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 33238952 254 TLIYMYMKPQNTISHEEGQFFT-LFYTivTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15330 214 ALVLPFCESTCHMPELLGAIINwLGYS--NSLLNPIIYAYFNKDFQSA 259
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
26-301 4.63e-05

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 44.34  E-value: 4.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15073   2 IVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQP--------LHYTVimhpvlcqkMVLSAWLGGLGSALilcsltlkLPRCGHREVDNF 177
Cdd:cd15073  82 FFGMASIGLLTVVAVDRYLTICRPdlgrkmttNTYTV---------MILLAWTNAFFWAA--------MPLVGWASYALD 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 178 FCEMPALIKMACVYSRVIE--IVVFTLGVIfllVPLSLILISYAVITQAVmKIKSATRWRKVLNTCGSHLTVVTLFYGTL 255
Cdd:cd15073 145 PTGATCTINWRKNDSSFVSytMSVIVVNFI---VPLAVMFYCYYNVSRFV-KKVLASDCLESVNIDWTDQNDVTKMSVIM 220
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 256 IYMYM---KPQNT----ISHEEGQFFTLFYTIVTPSL-------NPLIYTLRNKDVKNAV 301
Cdd:cd15073 221 IVMFLvawSPYSIvclwASFGEPKKIPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
27-301 5.52e-05

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 43.82  E-value: 5.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALD 106
Cdd:cd14972   1 VLVVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVmAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWlgglgsalILCSLTLKLPRCGHREVDnffCEMPALIK 186
Cdd:cd14972  81 LLASAYSLLAI-AVDRYISIVHGLTYVNNVTNKRVKVLIALVW--------VWSVLLALLPVLGWNCVL---CDQESCSP 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 187 MACVYSRvieiVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRwRKVLNTCGSHL--------TVVTL-------- 250
Cdd:cd14972 149 LGPGLPK----SYLVLILVFFFIALVIIVFLYVRIFWCLWRHANAIA-ARQEAAVPAQPstsrklakTVVIVlgvflvcw 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238952 251 --FYGTLIYMYMKPQNTISHEEGQFFTLFyTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd14972 224 lpLLILLVLDVLCPSVCDIQAVFYYFLVL-ALLNSAINPIIYAFRLKEMRRAV 275
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
27-150 5.96e-05

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 43.77  E-value: 5.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVP----QMLVNLWgpkksiTYGGCVLQFF 102
Cdd:cd15323   3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPfslaNELMGYW------YFGQVWCNIY 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 33238952 103 FALD-LGATECLL-LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWL 150
Cdd:cd15323  77 LALDvLFCTSSIVhLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWL 126
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-153 6.63e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 43.65  E-value: 6.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTT-SIVPQMLVNL----WGPK---KSITYGGCVLQ 100
Cdd:cd15387   5 TVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDItfrfYGPDflcRLVKYLQVVGM 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238952 101 FffaldlgaTECLLLAVMAYDRYAAVCQPLHYtviMHPVLCQKMVLSAWLGGL 153
Cdd:cd15387  85 F--------ASTYMLLLMSIDRCLAICQPLRS---LHRRSDRVYVLFSWLLSL 126
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
33-197 8.62e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 43.52  E-value: 8.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  33 VFYIVTLVGNTTIILVSYLDSQL-HTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATE 111
Cdd:cd15104   8 VLSPLIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 112 CLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWL-GGLGSALILCSLTLKL----PRCG-----HREVDNFFCEM 181
Cdd:cd15104  88 VLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLySGLIGFLPLISPQFQQtsykGKCSffaafHPRVLLVLSCM 167
                       170
                ....*....|....*....
gi 33238952 182 ---PALIKMACVYSRVIEI 197
Cdd:cd15104 168 vffPALLLFVFCYCDILKI 186
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
32-294 9.08e-05

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 43.19  E-value: 9.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  32 FVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATE 111
Cdd:cd14964   6 SLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLAS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 112 CLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAW-LGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACV 190
Cdd:cd14964  86 IWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWgVSLLLSIPPLVGKGAIPRYNTLTGSCYLICTTIYLTWGFLL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 191 YSRVIEIVVFtlGVIFLLVPLSLILISYAVI-TQAVMKIKSATRWRKVLNTCGSHLTVVTLFYGTLIYMYMKPQNTISHE 269
Cdd:cd14964 166 VSFLLPLVAF--LVIFSRIVLRLRRRVRAIRsAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFILHALVAAGQGLNL 243
                       250       260
                ....*....|....*....|....*
gi 33238952 270 EgQFFTLFYTIVTPSLNPLIYTLRN 294
Cdd:cd14964 244 L-SILANLLAVLASTLNPFIYCLGN 267
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
26-221 9.11e-05

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 43.36  E-value: 9.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFyIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVP-QMLVNLWGPKksitYGGCVLQFFFA 104
Cdd:cd14993   3 LIVLYVVVF-LLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPlTLLENVYRPW----VFGEVLCKAVP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLG---ATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLgglgSALILCSLTLklprCGHREVDNFFCEM 181
Cdd:cd14993  78 YLQGvsvSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWV----IAIIIMLPLL----VVYELEEIISSEP 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 33238952 182 PALIKMACV----YSRVIEIVVFTLGVIFLLVPLSLILISYAVI 221
Cdd:cd14993 150 GTITIYICTedwpSPELRKAYNVALFVVLYVLPLLIISVAYSLI 193
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
26-149 9.31e-05

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 43.27  E-value: 9.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCvlQFFFAL 105
Cdd:cd15301   2 LIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVC--DTWLAI 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 33238952 106 D--LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAW 149
Cdd:cd15301  80 DylASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAW 125
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
26-157 9.34e-05

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 43.21  E-value: 9.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIvpQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15088   2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGM--PFLIHQFAIDGQWYFGEVMCKIITAL 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238952 106 DLGA--TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSAL 157
Cdd:cd15088  80 DANNqfTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSIL 133
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
26-130 1.04e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 43.30  E-value: 1.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15085   2 ILSFLMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVN 81
                        90       100
                ....*....|....*....|....*
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPL 130
Cdd:cd15085  82 YFGIVSLWSLTLLAYERYNVVCKPM 106
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
33-229 1.05e-04

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 43.15  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  33 VFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDL-----CYTTSIVPQMLVN-LWGPKKSItyggcVLQFFFALD 106
Cdd:cd15206   9 VIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLllavfCMPFTLVGQLLRNfIFGEVMCK-----LIPYFQAVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVmAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSA---LILCSLTLKLPRCGHRevdnffCEMpa 183
Cdd:cd15206  84 VSVSTFTLVAI-SLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMspiLVFSNLIPMSRPGGHK------CRE-- 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 33238952 184 lIKMACVYSRVIEIVvftLGVIFLLVPLSLILISYAVITQAVMKIK 229
Cdd:cd15206 155 -VWPNEIAEQAWYVF---LDLMLLVIPGLVMSVAYGLISWTLLEAK 196
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
26-130 1.10e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 43.25  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVD-LCYTTSIVPQMLVNLWGpKKSITYGGCVLQFFFA 104
Cdd:cd15082  15 VLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADfLVSLTGGTISFLTNARG-YFFLGVWACVLEGFAV 93
                        90       100
                ....*....|....*....|....*.
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPL 130
Cdd:cd15082  94 TFFGIVALWSLAVLAFERFFVICRPL 119
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
30-300 1.27e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 42.97  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNL-----WGPKKSItyggCVLQFFFA 104
Cdd:cd15305   6 LILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAIlydyaWPLPRYL----CPIWISLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGsalilcsLTLKLPRCGHREVDNFFcempal 184
Cdd:cd15305  82 VLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIG-------ISMPIPVIGLQDDEKVF------ 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 IKMACVYSRviEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSHLTVVTL----FYGTLIYMYM 260
Cdd:cd15305 149 VNGTCVLND--ENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLImwcpFFITNILSVL 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 33238952 261 KPQNTISHEEGQFFTLFYTI--VTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15305 227 CKEACDQKLMEELLNVFVWVgyVSSGINPLVYTLFNKTYRRA 268
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
28-222 1.34e-04

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 42.80  E-value: 1.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  28 SAVVFVfyivTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPkKSITYGG--CVLQFFFAL 105
Cdd:cd15394   8 SLVVLV----GVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEP-RGWVFGRfmCYFVFLMQP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 106 DLGATECLLLAVMAYDRYAAVCQPLHYTVIMHpvLCQKMVLSAWlgglgsaliLCSLTLKLPRCGHrevdNFFCEMPALI 185
Cdd:cd15394  83 VTVYVSVFTLTAIAVDRYYVTVYPLRRRISRR--TCAYIVAAIW---------LLSCGLALPAAAH----TYYVEFKGLD 147
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 33238952 186 KMACV---YSRVIEIVVFTLGVIFL--LVPLSLILISYAVIT 222
Cdd:cd15394 148 FSICEefwFGQEKQRLAYACSTLLItyVLPLLAISLSYLRIS 189
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
33-300 1.49e-04

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 42.72  E-value: 1.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  33 VFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKsITYGGCVLQFFFALD--LGAT 110
Cdd:cd15053   9 LLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGK-WYLGPILCDIYIAMDvmCSTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 111 ECLLLAVMAYDRYAAVCQPLHYTvimHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPALIkmacV 190
Cdd:cd15053  88 SIFNLCAISIDRYIAVTQPIKYA---RQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEECRFYNPDFI----I 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 191 YSRVIEIVvftlgvifllVPLSLILISYAVITQAVMKIKSATRWRKVLntCGSHLTVVTLFYGTLIY--MYMKPQNTISH 268
Cdd:cd15053 161 YSSISSFY----------IPCIVMLLLYYRIFRALRREKKATKTLAIV--LGVFLFCWLPFFTLNILnaICPKLQNQSCH 228
                       250       260       270
                ....*....|....*....|....*....|....
gi 33238952 269 --EEGQFFTLFYTIVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15053 229 vgPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKA 262
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
26-300 1.53e-04

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 42.35  E-value: 1.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVP----QMLVNLWGpkksitYGGCVLQF 101
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPlaiiRQLLGYWP------LGSHLCDF 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 102 FFALD--LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLgglgSALILCSLTLKLPRCGHREVDNffc 179
Cdd:cd15061  75 WISLDvlLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWV----ISLLITSPPLVGPSWHGRRGLG--- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 180 empalikmACVYSRVIEIVVFTLGVIFLLvPLSLILISYAVITQAVMKIKSATRWRKVLNTCgshLTVVTLFYGTLIYMY 259
Cdd:cd15061 148 --------SCYYTYDKGYRIYSSMGSFFL-PLLLMLFVYLRIFRVIAKERKTAKTLAIVVGC---FIVCWLPFFIMYLIE 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 33238952 260 MKPQNTISHEEGQFFT-LFYtiVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15061 216 PFCDCQFSEALSTAFTwLGY--FNSVINPFIYAFYNKDFRRA 255
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
25-130 1.72e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 42.56  E-value: 1.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIvPQMLVN------LWGPKksitygGCV 98
Cdd:cd15079   1 YLLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNsfyegwALGPL------GCQ 73
                        90       100       110
                ....*....|....*....|....*....|..
gi 33238952  99 LQFFFALDLGATECLLLAVMAYDRYAAVCQPL 130
Cdd:cd15079  74 IYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPL 105
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
26-300 1.73e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 42.57  E-value: 1.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVP----QMLVNLWgpkksiTYGGCVLQF 101
Cdd:cd15326   2 LLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPfsatLEILGYW------VFGRIFCDI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 102 FFALD-LGATECLL-LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWlgglgsalILCSLTLKLPRCGHREV---DN 176
Cdd:cd15326  76 WAAVDvLCCTASILsLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVW--------VLSTVISIGPLLGWKEPappDD 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 177 FFCEMPALIKMACVYSrvieivvftLGVIFllVPLSLILISYAVITQAVMKIksaTRWRKVLNTCGSHLTVVTL----FY 252
Cdd:cd15326 148 KVCEITEEPFYALFSS---------LGSFY--IPLIVILVMYCRVYIVALKF---SREKKAAKTLGIVVGMFILcwlpFF 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 33238952 253 GTL----IYMYMKPQNTIsheEGQFFTLFYtiVTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15326 214 IALplgsLFSHLKPPETL---FKIIFWLGY--FNSCLNPIIYPCSSKEFKRA 260
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
37-149 1.82e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 42.44  E-value: 1.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  37 VTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLwGPKKSITYG--GCVLQFFFALDLGATECLL 114
Cdd:cd15005  13 VSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASV-RHGSGWIYGalSCKVIAFLAVLFCFHSAFT 91
                        90       100       110
                ....*....|....*....|....*....|....*
gi 33238952 115 LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAW 149
Cdd:cd15005  92 LFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
21-150 2.36e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 41.83  E-value: 2.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  21 PQLEHIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVN-LWGpkkSITYGGCVL 99
Cdd:cd15321   3 VQATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANeLMG---YWYFRKTWC 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238952 100 QFFFALD-LGATECLL-LAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWL 150
Cdd:cd15321  80 EIYLALDvLFCTSSIVhLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWL 132
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
26-151 2.45e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 42.10  E-value: 2.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVnlWGPKKSITYGGCVLQFFFAL 105
Cdd:cd15063   2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAV--NEVLDVWIFGHTWCQIWLAV 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33238952 106 D--LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLG 151
Cdd:cd15063  80 DvwMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVL 127
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
31-227 2.56e-04

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 41.88  E-value: 2.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  31 VFVFYIVTLV----GNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALD 106
Cdd:cd15001   2 VIIVYVITFVlgliGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGglgsalilcSLTLKLPRCGHREVDNFFCEMPALIK 186
Cdd:cd15001  82 SFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWIL---------SAILASPVLFGQGLVRYESENGVTVY 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 33238952 187 MACVYSRVIEIVVF---TLGVIFLLVPLSLILISYAVIT-QAVMK 227
Cdd:cd15001 153 HCQKAWPSTLYSRLyvvYLAIVIFFIPLIVMTFAYARDTrKQVIK 197
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
23-300 2.86e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 41.70  E-value: 2.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  23 LEHIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPqmLVNLWGPKKSITYGGCVLQFF 102
Cdd:cd15333   3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMP--ISIVYTVTGTWTLGQVVCDIW 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 103 FALDLgaTEC----LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWlgglgsaliLCSLTLKLPRCGHREVdnff 178
Cdd:cd15333  81 LSSDI--TCCtasiLHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVW---------VISISISLPPFFWRQA---- 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 179 cEMPALIKMACVYSRVIEIVVF-TLGVIFllVPLSLILISYAVITqavmkIKSATRWRKVLNTCGSHLTV-----VTLFY 252
Cdd:cd15333 146 -KAEEEVSECVVNTDHILYTVYsTVGAFY--IPTLLLIALYGRIY-----VEARARERKATKTLGIILGAfivcwLPFFI 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 33238952 253 GTLIYMYMKPQNTISHEEGQFFTLFYTIVTPsLNPLIYTLRNKDVKNA 300
Cdd:cd15333 218 ISLVLPICKDACWFHLAIFDFFTWLGYLNSL-INPIIYTMSNEDFKQA 264
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-301 4.80e-04

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 41.32  E-value: 4.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIvPQMLVNLWGPKKSItYGGCVLQFFFALD 106
Cdd:cd15132   3 VTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCL-PFDLYRLWKSRPWI-FGEFLCRLYHYIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVMAY--DRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLT-LKLPRCGHREVDNFFCEMPA 183
Cdd:cd15132  81 EGCTYATILHITALsiERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVgVEQDNNIHPDDFSRECKHTP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 184 likmACVYSRVIEIVVFTLGVIFLLvPLSLILISYAVITQAVMKIKSATRWRKVLNTCGSH------LTVVTLFYGTLIY 257
Cdd:cd15132 161 ----YAVSSGLLGIMIWVTTTYFFL-PMLCLSFLYGFIGRKLWKSKNDLRGPNAAARERSHrqtvriLAVVVLAFIICWL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238952 258 MYMKPQNTISHEEGQ---FFTLFYTIV-------TPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15132 236 PFHIGRILFANTEDYrtmMFSQYFNIVamqlfylSASINPILYNLISRKYRAAA 289
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
26-300 5.26e-04

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 41.01  E-value: 5.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVN----LWgpkksiTYGGCVLQF 101
Cdd:cd15324   2 LIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANevmgYW------YFGSTWCAF 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 102 FFALDL--GATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLgglgSALILCSLTLKLPRCGHREvdnffc 179
Cdd:cd15324  76 YLALDVlfCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWV----ISAVISFPPLLMTKHDEWE------ 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 180 empalikmaCVYSRVIEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATRWRKVLnTCGSHLTVVTLFYGTLIYMY 259
Cdd:cd15324 146 ---------CLLNDETWYILSSCTVSFFAPGLIMILVYCKIYRVAKMREKRFTFVLAVV-MGVFVLCWFPFFFTYSLHAV 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 33238952 260 MKPQNTISheeGQFFTLFYTI--VTPSLNPLIYTLRNKDVKNA 300
Cdd:cd15324 216 CRKRCGIP---DALFNLFFWIgyCNSSVNPIIYTIFNRDFRKA 255
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
26-150 5.47e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 40.89  E-value: 5.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVF-YIVTLVGN-TTIILVSYLDsQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLwgpKKSITYGG---CVLQ 100
Cdd:cd15317   1 VIIYIVLVLaMLITVSGNlVVIISISHFK-QLHSPTNMLVLSLATADFLLGLCVMPFSMIRT---VETCWYFGdlfCKFH 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 33238952 101 FFFALDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWL 150
Cdd:cd15317  77 TGLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
36-300 5.68e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 41.09  E-value: 5.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  36 IVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKksITYGGCVLQFFFALDLGATECLLL 115
Cdd:cd14968  12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLP--TNFHGCLFMACLVLVLTQSSIFSL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 116 AVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALI-LCSLTLKLPRCGHREVDNFFCEMPALIKMacvysrv 194
Cdd:cd14968  90 LAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTpMFGWNNGAPLESGCGEGGIQCLFEEVIPM------- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 195 iEIVVFTLGVIFLLVPLSLILISYA----VITQAVMKIKSATR-------WRKVLNTCGSHLTVVTLFYGTLIYMYMkpQ 263
Cdd:cd14968 163 -DYMVYFNFFACVLVPLLIMLVIYLrifrVIRKQLRQIESLLRsrrsrstLQKEVKAAKSLAIILFLFALCWLPLHI--I 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 33238952 264 NTISHEEGQFFT---LFYTIVTPS-----LNPLIYTLRNKDVKNA 300
Cdd:cd14968 240 NCITLFCPECKVpkiLTYIAILLShansaVNPIVYAYRIRKFRQT 284
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
26-221 6.03e-04

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 41.00  E-value: 6.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNT-TIILVSYLdSQLHTPMYFFLSNLSFVDLCYTTSIVP-QMLvnlwgpkKSIT---YGG---C 97
Cdd:cd15055   2 LLYIVLSSISLLTVLGNLlVIISISHF-KQLHTPTNLLLLSLAVADFLVGLLVMPfSMI-------RSIEtcwYFGdtfC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  98 VLQFFFALDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILcsLTLKLPRCGHREVDNF 177
Cdd:cd15055  74 KLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVL--LYDNLNQPGLIRYNSC 151
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 33238952 178 FCEmpalikmaCVYSRVIEIVVFTLGVIFLLvPLSLILISYAVI 221
Cdd:cd15055 152 YGE--------CVVVVNFIWGVVDLVLTFIL-PCTVMIVLYMRI 186
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
29-130 6.17e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 40.94  E-value: 6.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTT-SIVPQMLvnlWgpkkSITYGG------C-VLQ 100
Cdd:cd15386   5 GVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLI---W----EITYRFqgpdllCrAVK 77
                        90       100       110
                ....*....|....*....|....*....|
gi 33238952 101 FFFALDLGATECLLLAvMAYDRYAAVCQPL 130
Cdd:cd15386  78 YLQVLSMFASTYMLIM-MTVDRYIAVCHPL 106
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
33-233 6.61e-04

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 40.72  E-value: 6.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  33 VFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLC--------YTTSIVpqmlVNLWGpkksitYGGCVLQFFFA 104
Cdd:cd17790   9 ILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIigafsmnlYTTYIL----MGHWA------LGTVACDLWLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATEC--LLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLggLGSALILCSLTLKLPRCGHREVDNFFCEMP 182
Cdd:cd17790  79 LDYVASNAsvMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWL--ISFVLWAPAILFWQYLVGERTVLAGQCYIQ 156
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 33238952 183 ALIKmacvysrviEIVVFTLGVIFLLVPLSLILISYAVITQAVMKIKSATR 233
Cdd:cd17790 157 FLSQ---------PIITFGTAIAAFYLPVTIMIILYWRIYRETIKEKKAAR 198
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
26-150 6.80e-04

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 40.72  E-value: 6.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLcyttsIVPQMLVNLWGPKKSITY---GGCVLQFF 102
Cdd:cd15297   2 FIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADL-----IIGVFSMNLYTLYTVIGYwplGPVVCDLW 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 33238952 103 FALD--LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWL 150
Cdd:cd15297  77 LALDyvVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWV 126
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
29-153 1.17e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 40.19  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTT-SIVPQMLVNLWGPKKSITYGGCVLQFFFALDL 107
Cdd:cd15385   5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGM 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 33238952 108 GATECLLLaVMAYDRYAAVCQPLHyTVIMHPVLCQKMVLSAWLGGL 153
Cdd:cd15385  85 FASTYMLV-MMTADRYIAICHPLK-TLQQPTKRSYLMIGSAWALSF 128
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
27-130 1.32e-03

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 39.82  E-value: 1.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLC-----YTTSIVPQML-VNLWGPKksitygGCVLQ 100
Cdd:cd15080   3 LAAYMFLLILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFmvfggFTTTMYTSMHgYFVFGPT------GCNLE 76
                        90       100       110
                ....*....|....*....|....*....|
gi 33238952 101 FFFALDLGATECLLLAVMAYDRYAAVCQPL 130
Cdd:cd15080  77 GFFATLGGEIALWSLVVLAIERYVVVCKPM 106
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
26-150 1.38e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 39.64  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVN-LWGPKksiTYGGCVLQFFFA 104
Cdd:cd15065   1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNdLLGYW---LFGETFCNIWIS 77
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33238952 105 LDL--GATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWL 150
Cdd:cd15065  78 FDVmcSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWI 125
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
27-150 1.45e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 39.40  E-value: 1.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALD 106
Cdd:cd15054   3 VAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVM 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 33238952 107 LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWL 150
Cdd:cd15054  83 CCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWT 126
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
25-157 1.51e-03

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 39.70  E-value: 1.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15336   1 YTVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCG 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSAL 157
Cdd:cd15336  81 ALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSL 133
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-130 1.65e-03

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 39.35  E-value: 1.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSI---VPQMLVNLWgpkksiTYG--GCVLqf 101
Cdd:cd14999   2 IGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIpfyVSTYFLKKW------YFGdvGCRL-- 73
                        90       100       110
                ....*....|....*....|....*....|.
gi 33238952 102 FFALDLGA--TECLLLAVMAYDRYAAVCQPL 130
Cdd:cd14999  74 LFSLDFLTmhASIFTLTVMSTERYLAVVKPL 104
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
26-222 1.82e-03

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 39.41  E-value: 1.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGC-VLQFFFA 104
Cdd:cd15202   2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMChFSNFAQY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 105 LDLGATECLLLAVmAYDRYAAVCQPLH------YTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRcghrevdnFF 178
Cdd:cd15202  82 CSVHVSAYTLTAI-AVDRYQAIMHPLKprisktKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVR--------SL 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 33238952 179 CeMPALIKMACVYSRVIEIVVFTLGVIFllvPLSLILISYAVIT 222
Cdd:cd15202 153 C-LEDWPERADLFWKYYDLALFILQYFL---PLLVISFAYARVG 192
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
27-150 2.05e-03

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 39.23  E-value: 2.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLcyTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALD 106
Cdd:cd15298   3 IATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADL--IIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALD 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 33238952 107 --LGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWL 150
Cdd:cd15298  81 yvVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWV 126
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
27-301 2.09e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 39.10  E-value: 2.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIvPQMLVNLWGPKKSItYGGCVLQFFFALD 106
Cdd:cd15131   3 ITVTCVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCM-PLDLYRLWQYRPWN-FGDLLCKLFQFVS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 107 LGATECLLLAVMAY--DRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALILCSLTLKLPRCGHREVDNFFCEMPAL 184
Cdd:cd15131  81 ESCTYSTILNITALsvERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKATEY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 185 ikmaCVYSRVIEIVVFTLGVIFLLvPLSLILISYAVITQAVMKiksatRWRKVLNTCGSH----------LTVVTLFYGT 254
Cdd:cd15131 161 ----AVRSGLLTIMVWVSSVFFFL-PVFCLTVLYSLIGRKLWR-----RRRENIGPNASHrdknnrqtvkMLAVVVFAFV 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 33238952 255 LI--------YMYMKPQNTISHEEGQF--------FTLFYtiVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15131 231 LCwlpfhvgrYLFSKSFEAGSLEIALIsqycnlvsFVLFY--LSAAINPILYNIMSKKYRVAA 291
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
27-150 2.47e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 38.77  E-value: 2.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVN----LWgpkksiTYGGCVLQFF 102
Cdd:cd15322   3 LIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANevmgYW------YFGKVWCEIY 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 33238952 103 FALDL--GATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWL 150
Cdd:cd15322  77 LALDVlfCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWV 126
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
30-136 2.84e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 38.62  E-value: 2.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  30 VVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQ-------FF 102
Cdd:cd15103   6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnvidSM 85
                        90       100       110
                ....*....|....*....|....*....|....
gi 33238952 103 FALDLGATECLLLAVmAYDRYAAVCQPLHYTVIM 136
Cdd:cd15103  86 ICSSLLASICSLLAI-AVDRYITIFYALRYHSIM 118
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
26-150 3.50e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 38.61  E-value: 3.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVF-YIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIvPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15094   1 LISAVLYGLiCIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGL-PFLIVTMILKYWPFGAAMCKIYMVLT 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWL 150
Cdd:cd15094  80 SINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWS 125
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
65-298 5.30e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 37.77  E-value: 5.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  65 NLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFALDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCqKM 144
Cdd:cd15002  42 NLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRIT-AV 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 145 VLSAWLggLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYSRVIEIVVFtlgviflLVPLSLILISYAVITQA 224
Cdd:cd15002 121 VASIWV--PACLLPLPQWLFRTVKQSEGVYLCILCIPPLAHEFMSAFVKLYPLFVF-------CLPLTFALFYFWRAYGQ 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 225 VMKIKSAT-------RWRKVLNTCgshLTVVTLF-------YGTLIYM-YMKPQNTISHeegQFFTLFYTIVTPSL---N 286
Cdd:cd15002 192 CQRRGTKTqnlrnqiRSRKLTHML---LSVVLAFtilwlpeWVAWLWLiHIKSSGSSPP---QLFNVLAQLLAFSIssvN 265
                       250
                ....*....|..
gi 33238952 287 PLIYTLRNKDVK 298
Cdd:cd15002 266 PIIFLLMSEEFR 277
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-132 6.07e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 37.79  E-value: 6.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  29 AVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCytTSIVPQMLVNLWGPKKSITYG--GCVLQFFFALD 106
Cdd:cd15197   5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLC--VGLINVLTDIIWRITVEWRAGdfACKVIRYLQVV 82
                        90       100
                ....*....|....*....|....*.
gi 33238952 107 LGATECLLLAVMAYDRYAAVCQPLHY 132
Cdd:cd15197  83 VTYASTYVLVALSIDRYDAICHPMNF 108
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
36-149 6.33e-03

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 37.61  E-value: 6.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  36 IVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVnlwgpkKSIT----YGGCVLQFFFALD--LGA 109
Cdd:cd15314  12 LVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMV------RSVEtcwyFGDLFCKIHSSFDitLCT 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAW 149
Cdd:cd15314  86 ASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISW 125
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
36-224 6.93e-03

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 37.61  E-value: 6.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  36 IVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNLWGpkKSITYGGCVLQFFFALDLGATECLLL 115
Cdd:cd15068  12 VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFIACFVLVLTQSSIFSL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 116 AVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWlggLGSALILCSLTLKLPRCGHREVDNFFCEMPALIKMACVYSRVI 195
Cdd:cd15068  90 LAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW---VLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVV 166
                       170       180       190
                ....*....|....*....|....*....|.
gi 33238952 196 EI--VVFTLGVIFLLVPLSLILISYAVITQA 224
Cdd:cd15068 167 PMnyMVYFNFFACVLVPLLLMLGVYLRIFLA 197
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
110-221 7.05e-03

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 37.48  E-value: 7.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 110 TECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWlgglgsaliLCSLTLKLPRCGHREVDNFFcEMPALIKMAC 189
Cdd:cd15122  87 ASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIW---------LLALLLALPAFVYRHVWKDE-GMNDRICEPC 156
                        90       100       110
                ....*....|....*....|....*....|...
gi 33238952 190 VYSRVIEIVVFTL-GVIFLLVPLSLILISYAVI 221
Cdd:cd15122 157 HASRGHAIFHYTFeTLVAFVLPFGVILFSYSVI 189
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
26-130 7.17e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 37.66  E-value: 7.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVfyIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVP----QMLVNLWgpkksiTYG--GCVL 99
Cdd:cd15390   4 SIVFVVMV--LVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVfnftYLLYNDW------PFGlfYCKF 75
                        90       100       110
                ....*....|....*....|....*....|.
gi 33238952 100 QFFFALDLGATECLLLAVMAYDRYAAVCQPL 130
Cdd:cd15390  76 SNFVAITTVAASVFTLMAISIDRYIAIVHPL 106
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
27-153 7.37e-03

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 37.58  E-value: 7.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  27 ISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVP----QMLVNLWgpkksiTYGGCVLQFF 102
Cdd:cd15327   3 VGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPfsatLEVLGFW------AFGRVFCDIW 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 33238952 103 FALDL--GATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGL 153
Cdd:cd15327  77 AAVDVlcCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSM 129
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
25-159 7.45e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 37.61  E-value: 7.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  25 HIISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTS-----IVPQMLVN--LWGPKKSITYGGC 97
Cdd:cd15354   1 VIAAEVFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSnawetITIYLLNNrhLVIEDAFVRHIDN 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33238952  98 VLQFFFALDLGATECLLLAVmAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALIL 159
Cdd:cd15354  81 VFDSLICISVVASMCSLLAI-AVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIF 141
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
26-136 7.57e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 37.58  E-value: 7.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFY-IVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTS-----IVPQMLVNLWGPKKSITYG-GCV 98
Cdd:cd15353   1 FVSPEVFVTLgIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSngsetVVITLLNGNDTDAQSFTVNiDNV 80
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 33238952  99 LQFFFALDLGATECLLLAVmAYDRYAAVCQPLHYTVIM 136
Cdd:cd15353  81 IDSVICSSLLASICSLLSI-AVDRYFTIFYALQYHNIM 117
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
26-158 7.94e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 37.44  E-value: 7.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMY-FFLSNLSFVDLCYTTSIVPQMLVNLWGPKKSITYGGCVLQFFFA 104
Cdd:cd15219   1 LLAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQVPgIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLE 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 33238952 105 LDLGATECLLLAVMAYDRYAAVCQPLHYTVIMHPVLCQKMVLSAWLGGLGSALI 158
Cdd:cd15219  81 TFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLV 134
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
26-301 9.33e-03

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 36.95  E-value: 9.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952  26 IISAVVFVFYIVTLVGNTTIILVSYLDSQLHTPMYFFLSNLSFVDLCYTTSIVPQMLVNlwgpKKSITY--GGCVLQFFF 103
Cdd:cd15331   2 LTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVY----EVSQHWflGPEVCDMWI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 104 ALD-LGATECLL-LAVMAYDRYAAVCQpLHYTVIMHPVLCQKMVLSAWlgglgSALILCSLTlklPRCGHREVDNFfceM 181
Cdd:cd15331  78 SMDvLCCTASILhLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVW-----FVSLIISIA---PLFGWKDEDDL---D 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33238952 182 PALIKMACVYSRVIEIVVF-TLGVIFllVPLSLILISYAVITQAvmkiksATRWRKVLNT----CGSHLTVVTLFYGTLI 256
Cdd:cd15331 146 RVLKTGVCLISQDYGYTIFsTVGAFY--VPLLLMIIIYWKIYQA------AKRERKAARTlaiiTGAFVVCWLPFFLVAL 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 33238952 257 YMYMKPQNTISHEEGQFFtLFYTIVTPSLNPLIYTLRNKDVKNAV 301
Cdd:cd15331 218 VMPFCGAWQISRFLESFF-LWLGYFNSLLNPIIYTIFSPDFRGAF 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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