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Conserved domains on  [gi|22129725|ref|NP_666391|]
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olfactory receptor family 10 subfamily D member 4B [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
25-299 8.97e-143

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15228:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 275  Bit Score: 403.74  E-value: 8.97e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  25 NVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFY 104
Cdd:cd15228   1 TILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 105 HCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAV 184
Cdd:cd15228  81 HFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 185 LLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP 264
Cdd:cd15228 161 LKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129725 265 SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15228 241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
 
Name Accession Description Interval E-value
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
25-299 8.97e-143

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 403.74  E-value: 8.97e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  25 NVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFY 104
Cdd:cd15228   1 TILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 105 HCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAV 184
Cdd:cd15228  81 HFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 185 LLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP 264
Cdd:cd15228 161 LKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129725 265 SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15228 241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
55-304 1.09e-35

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 129.93  E-value: 1.09e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725    55 LHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTI 134
Cdd:pfam13853  25 LHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTT 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725   135 IMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLI 214
Cdd:pfam13853 105 ILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVTSTFGIDSLLI 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725   215 VVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVI----VIYLQPNPSPLLSAIIQIFNNLVTPTINPLIYSL 290
Cdd:pfam13853 185 VLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIglsmVHRFGHNVPPLLQIMMANAYLFFPPVLNPIVYSV 264
                         250
                  ....*....|....
gi 22129725   291 RNKDVKAALRHVFL 304
Cdd:pfam13853 265 KTKQIRDCVKRMLL 278
 
Name Accession Description Interval E-value
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
25-299 8.97e-143

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 403.74  E-value: 8.97e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  25 NVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFY 104
Cdd:cd15228   1 TILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 105 HCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAV 184
Cdd:cd15228  81 HFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 185 LLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP 264
Cdd:cd15228 161 LKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129725 265 SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15228 241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-292 2.15e-107

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 313.65  E-value: 2.15e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP- 264
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSs 241
                       250       260
                ....*....|....*....|....*....
gi 22129725 265 -SPLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd13954 242 ySSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
26-299 1.51e-102

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 301.68  E-value: 1.51e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLF-LFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFY 104
Cdd:cd15225   1 LLLFvVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 105 HCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAV 184
Cdd:cd15225  81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 185 LLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP 264
Cdd:cd15225 161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129725 265 --SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15225 241 sySPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
27-299 2.99e-97

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 288.18  E-value: 2.99e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHC 106
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 107 IGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLL 186
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 187 LACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSP 266
Cdd:cd15942 163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 22129725 267 LLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15942 243 PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
53-299 1.89e-96

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 285.98  E-value: 1.89e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  53 PRLHTPMYFFLSNLSISDMGFCSTTAPKMLS-YLSGRGGgISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLR 131
Cdd:cd15421  29 SRLHTPMYFLLSQLSLMDLMLISTTVPKMATnFLSGRKS-ISFVGCGTQIFFFLTLGGAECLLLALMAYDRYVAICHPLR 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 132 YTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICF 211
Cdd:cd15421 108 YPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADTSAYETVVYVSGVLFLLIPF 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 212 FLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP--SPLLSAIIQIFNNLVTPTINPLIYS 289
Cdd:cd15421 188 SLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSyhSPEQDKVVSVFYTILTPMLNPLIYS 267
                       250
                ....*....|
gi 22129725 290 LRNKDVKAAL 299
Cdd:cd15421 268 LRNKEVLGAL 277
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
27-299 1.97e-96

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 286.27  E-value: 1.97e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKML-SYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15916   3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLaGFLEPGGKVISFGGCVAQLYFFH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15916  83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPS 265
Cdd:cd15916 163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 22129725 266 PLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15916 243 EALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
26-292 2.69e-93

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 277.85  E-value: 2.69e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15230   2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15230  82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP- 264
Cdd:cd15230 162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSs 241
                       250       260
                ....*....|....*....|....*....
gi 22129725 265 -SPLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15230 242 ySLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
49-292 3.73e-92

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 274.75  E-value: 3.73e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  49 VTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICF 128
Cdd:cd15911  25 VVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYLLAVMSYDRYLAICK 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 129 PLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSL 208
Cdd:cd15911 105 PLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSLVELVTFILSSIVTL 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 209 ICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP--NPSPLLSAIIQIFNNLVTPTINPL 286
Cdd:cd15911 185 PPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPstNTSRDLNKVFSLFYTVLTPLVNPL 264

                ....*.
gi 22129725 287 IYSLRN 292
Cdd:cd15911 265 IYSLRN 270
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
26-299 4.50e-89

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 267.21  E-value: 4.50e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFL-FSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFY 104
Cdd:cd15231   1 LLLFLiFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 105 HCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAV 184
Cdd:cd15231  81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 185 LLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP 264
Cdd:cd15231 161 LKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129725 265 --SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15231 241 gySLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
24-299 5.39e-89

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 267.17  E-value: 5.39e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  24 ENVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFF 103
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 104 YHCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPA 183
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 184 VLLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPN 263
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129725 264 P--SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15235 241 SsySADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
26-299 1.04e-88

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 266.33  E-value: 1.04e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHT-PMYFFLSNLSISDMGFCSTTAPKML-SYLSGRGGGISFQGCVVQHFF 103
Cdd:cd15941   2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLaGLLTLSGRTISFEGCVVQLYA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 104 YHCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPA 183
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 184 VLLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPN 263
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129725 264 PSPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15941 242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
53-292 1.09e-88

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 266.06  E-value: 1.09e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  53 PRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRY 132
Cdd:cd15237  29 SRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAVMAYDRYVAICNPLRY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 133 TIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFF 212
Cdd:cd15237 109 SVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSLNEAVIFVTSVLVLLIPFS 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 213 LIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP--NPSPLLSAIIQIFNNLVTPTINPLIYSL 290
Cdd:cd15237 189 LILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPhsTHSPDQDKMISVFYTIVTPMLNPLIYSL 268

                ..
gi 22129725 291 RN 292
Cdd:cd15237 269 RN 270
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
29-292 6.87e-88

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 263.93  E-value: 6.87e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  29 FLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPK-MLSYLSGRGGgISFQGCVVQHFFYHCI 107
Cdd:cd15227   5 VLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKsIANSLTNTRS-ISFLGCVAQVFLFIFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 108 GCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLL 187
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 188 ACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP--NPS 265
Cdd:cd15227 164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPpsDSP 243
                       250       260
                ....*....|....*....|....*..
gi 22129725 266 PLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15227 244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
26-300 1.42e-87

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 263.79  E-value: 1.42e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPK-MLSYLSGRgGGISFQGCVVQHFFY 104
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKaLANFLSES-KTISYNGCAAQFFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 105 HCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAV 184
Cdd:cd15419  81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 185 LLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP 264
Cdd:cd15419 161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129725 265 --SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAALR 300
Cdd:cd15419 241 vsSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALK 278
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-303 3.23e-87

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 263.37  E-value: 3.23e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  12 FTLLGIPETEGLENVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGG 91
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  92 ISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGP 171
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 172 SEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCV 251
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129725 252 YGPVIVIYLQPNP--SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAALRHVF 303
Cdd:cd15410 241 HGTILFMYCRPSSsySLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
26-299 3.82e-86

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 259.95  E-value: 3.82e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPS 265
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129725 266 --PLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15420 242 nsAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
11-303 1.31e-85

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 259.22  E-value: 1.31e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  11 EFTLLGIPETEGLENVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGG 90
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  91 GISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCG 170
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 171 PSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMC 250
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22129725 251 VYGPVIVIYLQPNPSPLLSA--IIQIFNNLVTPTINPLIYSLRNKDVKAALRHVF 303
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLDQdkVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
27-292 1.70e-85

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 257.93  E-value: 1.70e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLF-LFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15918   2 LLFgLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15918  82 LFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP- 264
Cdd:cd15918 162 KLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSs 241
                       250       260
                ....*....|....*....|....*....
gi 22129725 265 -SPLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15918 242 hSASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
26-292 5.56e-85

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 256.75  E-value: 5.56e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15226   2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKiRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPS 265
Cdd:cd15226 162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFST 240
                       250       260
                ....*....|....*....|....*..
gi 22129725 266 PLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15226 241 FPVDKFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
26-300 7.99e-84

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 254.10  E-value: 7.99e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLF-LFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFY 104
Cdd:cd15417   1 IILFvLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 105 HCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAV 184
Cdd:cd15417  81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 185 LLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP 264
Cdd:cd15417 161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129725 265 SPLLS--AIIQIFNNLVTPTINPLIYSLRNKDVKAALR 300
Cdd:cd15417 241 SHSQDqdKVASVFYTVVIPMLNPLIYSLRNKEIKDALK 278
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
53-299 1.95e-83

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 252.90  E-value: 1.95e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  53 PRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRY 132
Cdd:cd15229  29 SHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAMAYDRYAAICHPLHY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 133 TIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFF 212
Cdd:cd15229 109 VQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFANKMVLLTSSVIFGLGSFL 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 213 LIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSPL--LSAIIQIFNNLVTPTINPLIYSL 290
Cdd:cd15229 189 LTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSsvLDRVFSIQYSILTPMLNPIIYSL 268

                ....*....
gi 22129725 291 RNKDVKAAL 299
Cdd:cd15229 269 KNKEVKAAL 277
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
27-292 2.12e-83

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 252.75  E-value: 2.12e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHC 106
Cdd:cd15940   3 FFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 107 IGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLL 186
Cdd:cd15940  83 FACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 187 LACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKiRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSP 266
Cdd:cd15940 163 LACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRK-RSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241
                       250       260
                ....*....|....*....|....*.
gi 22129725 267 LLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15940 242 SEDKVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-296 7.38e-83

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 251.86  E-value: 7.38e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  12 FTLLGIPETEGLENVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGG 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  92 ISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGP 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 172 SEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCV 251
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129725 252 YGPVIVIYLQP--NPSPLLSAIIQIFNNLVTPTINPLIYSLRNKDVK 296
Cdd:cd15408 241 YGSLAFMYLRPssRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
26-292 1.90e-82

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 250.25  E-value: 1.90e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15232   2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15232  82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP--N 263
Cdd:cd15232 162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPssS 241
                       250       260
                ....*....|....*....|....*....
gi 22129725 264 PSPLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15232 242 YSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
26-300 2.68e-82

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 250.31  E-value: 2.68e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKML-SYLSGRGGgISFQGCVVQHFFY 104
Cdd:cd15411   2 PLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALeNFLSGRKA-ISFAGCFVQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 105 HCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAV 184
Cdd:cd15411  81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 185 LLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP 264
Cdd:cd15411 161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129725 265 SPLL--SAIIQIFNNLVTPTINPLIYSLRNKDVKAALR 300
Cdd:cd15411 241 SYSLgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALR 278
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
26-292 4.69e-82

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 249.06  E-value: 4.69e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVhATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15431  82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFL-LTVIPVLTMPLHFCGPNVINHFFCEVQALL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP--N 263
Cdd:cd15431 161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPqsK 240
                       250       260
                ....*....|....*....|....*....
gi 22129725 264 PSPLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15431 241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
53-292 1.18e-81

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 248.17  E-value: 1.18e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  53 PRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRY 132
Cdd:cd15912  29 HRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLAVMSFDRYVAICNPLHY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 133 TIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFF 212
Cdd:cd15912 109 PTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRLIELLDFILASVVLLGSLL 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 213 LIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP--SPLLSAIIQIFNNLVTPTINPLIYSL 290
Cdd:cd15912 189 LTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQssSLDLNKVVALLNTVVTPLLNPFIYTL 268

                ..
gi 22129725 291 RN 292
Cdd:cd15912 269 RN 270
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
26-292 1.38e-81

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 248.02  E-value: 1.38e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15936   2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15936  82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISIsKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPS 265
Cdd:cd15936 162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQT 240
                       250       260
                ....*....|....*....|....*..
gi 22129725 266 PLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15936 241 FPMDKAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
27-299 4.86e-81

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 246.93  E-value: 4.86e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHC 106
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 107 IGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLL 186
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 187 LACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP--NP 264
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPrsGS 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129725 265 SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
53-292 6.94e-81

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 246.38  E-value: 6.94e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  53 PRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRY 132
Cdd:cd15947  29 PRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVLLAVMAFDRYVAVCRPLHY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 133 TIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFF 212
Cdd:cd15947 109 TVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDTTFNELELFVASVFFLLVPLS 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 213 LIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP--NPSPLLSAIIQIFNNLVTPTINPLIYSL 290
Cdd:cd15947 189 LILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPpsSYSQDQGKFISLFYTVVTPTLNPLIYTL 268

                ..
gi 22129725 291 RN 292
Cdd:cd15947 269 RN 270
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
49-292 2.31e-80

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 244.81  E-value: 2.31e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  49 VTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICF 128
Cdd:cd15939  25 IKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTVMAYDRYVAICK 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 129 PLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSL 208
Cdd:cd15939 105 PLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTYVIGLLVVANSGLICL 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 209 ICFFLIVVSYTRIGISIsKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSPLLSAIIQIFNNLVTPTINPLIY 288
Cdd:cd15939 185 LSFLILLISYIVILYSL-RTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFPIDKVVAVFYTIITPMLNPLIY 263

                ....
gi 22129725 289 SLRN 292
Cdd:cd15939 264 TLRN 267
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
25-292 1.78e-79

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 242.60  E-value: 1.78e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  25 NVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFY 104
Cdd:cd15915   1 IFLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 105 HCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAV 184
Cdd:cd15915  81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 185 LLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISI-SKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPN 263
Cdd:cd15915 161 LKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLlLKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPS 240
                       250       260       270
                ....*....|....*....|....*....|.
gi 22129725 264 PSPLLSA--IIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15915 241 SGDSLEQdrIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
26-306 3.28e-79

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 242.72  E-value: 3.28e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15414   2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15414  82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPS 265
Cdd:cd15414 162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSS 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 22129725 266 PLLSA--IIQIFNNLVTPTINPLIYSLRNKDVKAALRHVFLKR 306
Cdd:cd15414 242 SSLDLdkVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRK 284
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
53-299 8.04e-78

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 238.82  E-value: 8.04e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  53 PRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRY 132
Cdd:cd15434  29 SRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVLLAVMAYDRYAAVCQPLHY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 133 TIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFF 212
Cdd:cd15434 109 TVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLACVDTTAYEATIFALGVFILLFPLS 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 213 LIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSPLLSA--IIQIFNNLVTPTINPLIYSL 290
Cdd:cd15434 189 LILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQDQgkFLTLFYTIVTPSLNPLIYTL 268

                ....*....
gi 22129725 291 RNKDVKAAL 299
Cdd:cd15434 269 RNKDVKGAL 277
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
26-300 1.93e-77

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 237.65  E-value: 1.93e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKML-SYLSGRGGgISFQGCVVQHFFY 104
Cdd:cd15416   2 ILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLvNFLVEKTT-ISYPGCAAQLCSA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 105 HCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAV 184
Cdd:cd15416  81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 185 LLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP 264
Cdd:cd15416 161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129725 265 SPLL--SAIIQIFNNLVTPTINPLIYSLRNKDVKAALR 300
Cdd:cd15416 241 SYSMdqNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALK 278
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-300 1.95e-77

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 238.11  E-value: 1.95e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  12 FTLLGIPETEGLENVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGG 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  92 ISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGP 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 172 SEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCV 251
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129725 252 YGPVIVIYLQPNP--SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAALR 300
Cdd:cd15945 241 YGTLLFMYLRPSSsySLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALK 291
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
26-300 9.10e-77

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 236.16  E-value: 9.10e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15415   2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15415  82 VFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPS 265
Cdd:cd15415 162 KLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQ 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129725 266 PLL--SAIIQIFNNLVTPTINPLIYSLRNKDVKAALR 300
Cdd:cd15415 242 YSLeqEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALK 278
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
27-300 2.97e-75

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 232.30  E-value: 2.97e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHC 106
Cdd:cd15409   3 LFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 107 IGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLL 186
Cdd:cd15409  83 SATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 187 LACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSP 266
Cdd:cd15409 163 ISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLY 242
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129725 267 LL--SAIIQIFNNLVTPTINPLIYSLRNKDVKAALR 300
Cdd:cd15409 243 ALdqDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALR 278
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
53-299 1.59e-74

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 230.44  E-value: 1.59e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  53 PRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRY 132
Cdd:cd15432  29 PQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVLLAVMAFDRFAAICQPLHY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 133 TIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFF 212
Cdd:cd15432 109 SVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTANEAELFVISVLLLLIPLG 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 213 LIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP--NPSPLLSAIIQIFNNLVTPTINPLIYSL 290
Cdd:cd15432 189 LILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPpsNSSHDRGKMVALFYGIITPMLNPLIYTL 268

                ....*....
gi 22129725 291 RNKDVKAAL 299
Cdd:cd15432 269 RNKDVKEAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
26-292 2.50e-74

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 229.67  E-value: 2.50e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15946  82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP- 264
Cdd:cd15946 162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSn 241
                       250       260
                ....*....|....*....|....*....
gi 22129725 265 -SPLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15946 242 ySPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
48-299 8.67e-74

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 228.23  E-value: 8.67e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  48 AVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAIC 127
Cdd:cd15234  24 AVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLLAVMAYDRYVAIC 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 128 FPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLS 207
Cdd:cd15234 104 HPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTLINNILIYLATVIFG 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 208 LICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPN--PSPLLSAIIQIFNNLVTPTINP 285
Cdd:cd15234 184 GIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAvtHSSRKTAVASVMYTVVTPMLNP 263
                       250
                ....*....|....
gi 22129725 286 LIYSLRNKDVKAAL 299
Cdd:cd15234 264 FIYSLRNKDMKGAL 277
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
27-299 1.28e-73

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 228.13  E-value: 1.28e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHC 106
Cdd:cd15428   3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 107 IGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLL 186
Cdd:cd15428  83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 187 LACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPN--P 264
Cdd:cd15428 163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKssT 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129725 265 SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15428 243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-303 3.48e-73

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 227.36  E-value: 3.48e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  12 FTLLGIPETEGLENVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGG 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  92 ISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGP 171
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 172 SEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCV 251
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129725 252 YGPVIVIYLQPNP--SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAALRHVF 303
Cdd:cd15944 241 YGTVIFMYLRPTSvySLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
26-300 6.55e-73

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 226.13  E-value: 6.55e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15412   2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15412  82 ALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPS 265
Cdd:cd15412 162 KLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSE 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129725 266 PLL--SAIIQIFNNLVTPTINPLIYSLRNKDVKAALR 300
Cdd:cd15412 242 ESVeqSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALK 278
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
26-292 1.04e-72

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 225.24  E-value: 1.04e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLF-LFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFY 104
Cdd:cd15224   1 LLLFlLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 105 HCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAV 184
Cdd:cd15224  81 LSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 185 LLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP 264
Cdd:cd15224 161 LNLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKA 240
                       250       260       270
                ....*....|....*....|....*....|
gi 22129725 265 SPLLSA--IIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15224 241 ISSFDSnkLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
27-292 5.08e-72

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 223.60  E-value: 5.08e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHC 106
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 107 IGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLL 186
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 187 LACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIgisISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSP 266
Cdd:cd15938 163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239
                       250       260
                ....*....|....*....|....*.
gi 22129725 267 LLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15938 240 PVDKHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
53-299 7.13e-72

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 223.49  E-value: 7.13e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  53 PRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRY 132
Cdd:cd15236  29 SHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFLLAVMAYDRYVAICHPLHY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 133 TIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFF 212
Cdd:cd15236 109 TAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSLNELVIFTEGGLLFVLPLL 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 213 LIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP--NPSPLLSAIIQIFNNLVTPTINPLIYSL 290
Cdd:cd15236 189 LILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPssNNSSDKDIVASVMYTVVTPMLNPFIYSL 268

                ....*....
gi 22129725 291 RNKDVKAAL 299
Cdd:cd15236 269 RNRDIKGAL 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
53-292 7.75e-72

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 223.02  E-value: 7.75e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  53 PRLHTPMYFFLSNLSISDMGFCSTTAPKML-SYLSGRGGgISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLR 131
Cdd:cd15430  29 SHLHTPMYFFLGNLSFLDICYTSSSVPLMLvNFLSERKT-ISFSGCAVQMYLSLAMGSTECVLLAVMAYDRYVAICNPLR 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 132 YTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICF 211
Cdd:cd15430 108 YPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISLNEIIMLVGNIIFLVIPL 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 212 FLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP--SPLLSAIIQIFNNLVTPTINPLIYS 289
Cdd:cd15430 188 LLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSknAQISDKLITLFYGVVTPMLNPIIYS 267

                ...
gi 22129725 290 LRN 292
Cdd:cd15430 268 LRN 270
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
16-302 1.49e-71

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 223.01  E-value: 1.49e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  16 GIPETEGLENVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQ 95
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  96 GCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVS 175
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 176 YYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPV 255
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129725 256 IVIYLQPNPSpllSAIIQ-----IFNNLVTPTINPLIYSLRNKDVKAALRHV 302
Cdd:cd15406 241 IFMYLKPSSS---SSMTQekvssVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
52-300 8.57e-71

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 220.66  E-value: 8.57e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  52 SPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLR 131
Cdd:cd15413  28 DSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLLSAMAYDRYVAICNPLL 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 132 YTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGlLSLICF 211
Cdd:cd15413 108 YTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTHEKELIILIFAG-FNLISS 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 212 FLIV-VSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSPLLSA--IIQIFNNLVTPTINPLIY 288
Cdd:cd15413 187 LLIVlVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDTdkMASVFYTLVIPMLNPLIY 266
                       250
                ....*....|..
gi 22129725 289 SLRNKDVKAALR 300
Cdd:cd15413 267 SLRNKEVKDALK 278
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
54-299 7.19e-70

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 218.45  E-value: 7.19e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  54 RLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYT 133
Cdd:cd15424  30 RLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGAMAYDRYLAICHPLLYA 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 134 IIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFL 213
Cdd:cd15424 110 AAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHITEAIVFGAGVLILLVPLSV 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 214 IVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP--NPSPLLSAIIQIFNNLVTPTINPLIYSLR 291
Cdd:cd15424 190 ILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPrsGSTPDRDKQIAVFYIVITPLLNPIIYTLR 269

                ....*...
gi 22129725 292 NKDVKAAL 299
Cdd:cd15424 270 NKDVHGAA 277
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
26-292 2.19e-69

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 216.85  E-value: 2.19e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP--N 263
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLskS 241
                       250       260
                ....*....|....*....|....*....
gi 22129725 264 PSPLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15914 242 YSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
26-299 2.61e-69

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 216.90  E-value: 2.61e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15407   2 PLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15407  82 VFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPS 265
Cdd:cd15407 162 ALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSS 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129725 266 PLLSA--IIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15407 242 HSMDTdkMASVFYTMVIPMLNPLVYSLRNKEVKSAF 277
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
26-292 4.03e-67

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 211.13  E-value: 4.03e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISIsKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPS 265
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKL-RTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRS 240
                       250       260
                ....*....|....*....|....*..
gi 22129725 266 PLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15937 241 FPMDKVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
27-292 7.97e-67

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 210.39  E-value: 7.97e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLFLFSTLYACALLGNLLLLTAVTSSPRL-HTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15935   3 LFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15935  83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISIsKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPS 265
Cdd:cd15935 163 KLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTL-RGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241
                       250       260
                ....*....|....*....|....*..
gi 22129725 266 PLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15935 242 SSVDKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
27-292 1.10e-63

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 202.16  E-value: 1.10e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHC 106
Cdd:cd15913   3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 107 IGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLL 186
Cdd:cd15913  83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 187 LACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP-- 264
Cdd:cd15913 163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSgn 242
                       250       260
                ....*....|....*....|....*...
gi 22129725 265 SPLLSAIIQIFNNLVTPTINPLIYSLRN 292
Cdd:cd15913 243 STGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
26-300 7.62e-63

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 200.39  E-value: 7.62e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15418   3 ILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15418  83 GLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPS 265
Cdd:cd15418 163 KLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSS 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129725 266 --PLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAALR 300
Cdd:cd15418 243 htPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALK 279
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
52-299 8.99e-63

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 200.40  E-value: 8.99e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  52 SPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLR 131
Cdd:cd15433  28 DLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLAVMAFDRYAAVCRPLH 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 132 YTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICF 211
Cdd:cd15433 108 YAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDETTEVQMFVARVVILLLPA 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 212 FLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP--SPLLSAIIQIFNNLVTPTINPLIYS 289
Cdd:cd15433 188 ALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHrySQAHGKFVSLFYTVMTPALNPLIYT 267
                       250
                ....*....|
gi 22129725 290 LRNKDVKAAL 299
Cdd:cd15433 268 LRNKDVKGAL 277
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
26-299 1.66e-62

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 199.63  E-value: 1.66e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15233   2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15233  82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNP- 264
Cdd:cd15233 162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSv 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129725 265 -SPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15233 242 ySSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
27-299 1.15e-59

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 192.25  E-value: 1.15e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHC 106
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 107 IGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLL 186
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 187 LACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQpnPSP 266
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLK--PSS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129725 267 LLSA----IIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15405 241 VGSVnqgkVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
27-299 3.79e-51

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 170.17  E-value: 3.79e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  27 LLFL-FSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15223   2 WLSLpFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVL 185
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 186 LLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPN-- 263
Cdd:cd15223 162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRfg 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129725 264 --PSPLLSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd15223 242 ktIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
31-293 1.94e-47

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 160.53  E-value: 1.94e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  31 FSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCV 110
Cdd:cd15917   7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 111 LCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACE 190
Cdd:cd15917  87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 191 DSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQP----NPSP 266
Cdd:cd15917 167 DTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHrfghHVPP 246
                       250       260
                ....*....|....*....|....*..
gi 22129725 267 LLSAIIQIFNNLVTPTINPLIYSLRNK 293
Cdd:cd15917 247 HVHILLANLYLLLPPMLNPIVYGVRTK 273
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
29-293 6.39e-45

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 153.81  E-value: 6.39e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  29 FLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIG 108
Cdd:cd15222   5 IPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 109 CVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLA 188
Cdd:cd15222  85 FMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 189 CEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYL----QPNP 264
Cdd:cd15222 165 CSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMvhrfGKHA 244
                       250       260
                ....*....|....*....|....*....
gi 22129725 265 SPLLSAIIQIFNNLVTPTINPLIYSLRNK 293
Cdd:cd15222 245 SPLVHVLMANVYLLVPPVLNPIIYSVKTK 273
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
29-295 1.36e-44

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 153.34  E-value: 1.36e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  29 FLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIG 108
Cdd:cd15950   5 IPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 109 CVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLA 188
Cdd:cd15950  85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 189 CEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIV-IYLQPNPSPl 267
Cdd:cd15950 165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQRFGQG- 243
                       250       260       270
                ....*....|....*....|....*....|..
gi 22129725 268 LSAIIQI----FNNLVTPTINPLIYSLRNKDV 295
Cdd:cd15950 244 VPPHTQVlladLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
31-293 2.63e-44

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 152.44  E-value: 2.63e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  31 FSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCV 110
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 111 LCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACE 190
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 191 DSSLAQRVGFTnVGLLSLIC-FFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSPLLS 269
Cdd:cd15221 167 DITVNIWYGLT-VALLTVGLdVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRHIP 245
                       250       260
                ....*....|....*....|....*...
gi 22129725 270 AIIQI-FNNL---VTPTINPLIYSLRNK 293
Cdd:cd15221 246 RHVHIlLANLyvlVPPMLNPIVYGVKTK 273
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
29-295 1.01e-42

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 148.30  E-value: 1.01e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  29 FLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIG 108
Cdd:cd15952   5 FPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 109 CVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLA 188
Cdd:cd15952  85 GMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 189 CEDsslAQRVGFTNVGLLSLICF--FLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSP 266
Cdd:cd15952 165 CAS---IRINIIYGLFAISVLVLdvILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGH 241
                       250       260       270
                ....*....|....*....|....*....|...
gi 22129725 267 LLSAIIQI----FNNLVTPTINPLIYSLRNKDV 295
Cdd:cd15952 242 NIPRYIHIllanLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
31-295 1.35e-42

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 147.88  E-value: 1.35e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  31 FSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCV 110
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 111 LCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACE 190
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 191 DSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQ-------PN 263
Cdd:cd15951 167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLThrfghnvPP 246
                       250       260       270
                ....*....|....*....|....*....|..
gi 22129725 264 PSPLLSAIIQIfnnLVTPTINPLIYSLRNKDV 295
Cdd:cd15951 247 HVHILIANVYL---LVPPMLNPIIYGVRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
10-296 1.65e-41

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 145.69  E-value: 1.65e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  10 TEFTLLGIPETEGLENVLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRG 89
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  90 GGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYC 169
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 170 GPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIM 249
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129725 250 CVYGPVIVIYL----QPNPSPLLSAIIQIFNNLVTPTINPLIYSLRNKDVK 296
Cdd:cd15949 242 AFYVPIAVSSLihrfGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
31-296 1.41e-40

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 142.74  E-value: 1.41e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  31 FSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCV 110
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 111 LCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACE 190
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 191 DSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVI----VIYLQPNPSP 266
Cdd:cd15948 168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVlsstMHRFARHVAP 247
                       250       260       270
                ....*....|....*....|....*....|
gi 22129725 267 LLSAIIQIFNNLVTPTINPLIYSLRNKDVK 296
Cdd:cd15948 248 HVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
31-293 3.77e-40

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 141.63  E-value: 3.77e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  31 FSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCV 110
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 111 LCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACE 190
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 191 DSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQ----PNPSP 266
Cdd:cd15953 167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLThrfgQGIAP 246
                       250       260
                ....*....|....*....|....*..
gi 22129725 267 LLSAIIQIFNNLVTPTINPLIYSLRNK 293
Cdd:cd15953 247 HIHIILANLYLLVPPMLNPIIYGVKTK 273
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
55-295 1.01e-36

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 132.64  E-value: 1.01e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  55 LHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTI 134
Cdd:cd15954  31 LHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGVLMLMALDRYVAICYPLRYAT 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 135 IMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLI 214
Cdd:cd15954 111 ILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIRVDAIYGLMVALLIGGFDILCI 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 215 VVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQ-----PNPSPLLSAIIQIFNNLVTPTINPLIYS 289
Cdd:cd15954 191 SVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAhrfggHHITPHIHIIMANLYLLLPPMMNPIVYG 270

                ....*.
gi 22129725 290 LRNKDV 295
Cdd:cd15954 271 VKTKQI 276
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
55-304 1.09e-35

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 129.93  E-value: 1.09e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725    55 LHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTI 134
Cdd:pfam13853  25 LHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTT 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725   135 IMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACEDSSLAQRVGFTNVGLLSLICFFLI 214
Cdd:pfam13853 105 ILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVTSTFGIDSLLI 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725   215 VVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVI----VIYLQPNPSPLLSAIIQIFNNLVTPTINPLIYSL 290
Cdd:pfam13853 185 VLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIglsmVHRFGHNVPPLLQIMMANAYLFFPPVLNPIVYSV 264
                         250
                  ....*....|....
gi 22129725   291 RNKDVKAALRHVFL 304
Cdd:pfam13853 265 KTKQIRDCVKRMLL 278
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
31-295 2.87e-34

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 126.13  E-value: 2.87e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  31 FSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCV 110
Cdd:cd15956   7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 111 LCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACE 190
Cdd:cd15956  87 ESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 191 DSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQ----PNPSP 266
Cdd:cd15956 167 ATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMhrfgHSVPS 246
                       250       260
                ....*....|....*....|....*....
gi 22129725 267 LLSAIIQIFNNLVTPTINPLIYSLRNKDV 295
Cdd:cd15956 247 AAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
31-295 2.78e-28

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 110.24  E-value: 2.78e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  31 FSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCV 110
Cdd:cd15955   7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 111 LCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCL-TFQLPYCGPSEVSYYFCDMPAVLLLAC 189
Cdd:cd15955  87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLiKLRLHHFRSTVISHSYCEHMAVVKLAA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 190 EDSSLAQRVGFTNVGLLSLICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQ----PNPS 265
Cdd:cd15955 167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAhrfgHHVA 246
                       250       260       270
                ....*....|....*....|....*....|
gi 22129725 266 PLLSAIIQIFNNLVTPTINPLIYSLRNKDV 295
Cdd:cd15955 247 PYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
47-288 6.77e-26

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 103.53  E-value: 6.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725    47 TAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGG-ISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVA 125
Cdd:pfam00001   7 LVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWpFGSALCKIVGALFVVNGYASILLLTAISIDRYLA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725   126 ICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVsyyFCDMPAVLLLACEDSslaqrVGFTNVGL 205
Cdd:pfam00001  87 IVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVT---VCFIDFPEDLSKPVS-----YTLLISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725   206 LSLICFFLIVVSYTRIGISISKIRSTEGR-------QRAFSTCSAHLTAIMCVYGPVIVIYL------QPNPSPLLSAII 272
Cdd:pfam00001 159 GFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLldslalDCELSRLLDKAL 238
                         250
                  ....*....|....*...
gi 22129725   273 QIFNNL--VTPTINPLIY 288
Cdd:pfam00001 239 SVTLWLayVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
48-292 1.15e-20

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 89.66  E-value: 1.15e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  48 AVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAIC 127
Cdd:cd00637  22 VILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLAIV 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 128 FPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAvlllacedsslAQRVGFTNVGLLS 207
Cdd:cd00637 102 HPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTL-----------SKAYTIFLFVLLF 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 208 LICFFLIVVSYTRIGISISKIRSTEGRQRAFSTCSAH----------LTAIMCVY----GPVIVIYLQPNPSPLLSAIIQ 273
Cdd:cd00637 171 LLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRrrrerkvtktLLIVVVVFllcwLPYFILLLLDVFGPDPSPLPR 250
                       250       260
                ....*....|....*....|....*
gi 22129725 274 IFNNLVT------PTINPLIYSLRN 292
Cdd:cd00637 251 ILYFLALllaylnSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
48-299 3.74e-08

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 53.34  E-value: 3.74e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  48 AVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVvqhfFYHCIGCVLCFL----YTVMAYDRF 123
Cdd:cd14967  23 AVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCR----FWIALDVLCCTAsilnLCAISLDRY 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 124 VAICFPLRYTIIMNHRVCCVLATGTWmsgcVHATILTCLTFQL--PYCGPSEVSYYFCDMPavlllacedsslaqrvGFT 201
Cdd:cd14967  99 LAITRPLRYRQLMTKKRALIMIAAVW----VYSLLISLPPLVGwrDETQPSVVDCECEFTP----------------NKI 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 202 NVGLLSLICFFL----IVVSYTRigisISKIRSTEgrQRAFSTcsahLTAIMCVYG----PVIVIYL--QPNPSPLLSAI 271
Cdd:cd14967 159 YVLVSSVISFFIplliMIVLYAR----IFRVARRE--LKAAKT----LAIIVGAFLlcwlPFFIIYLvsAFCPPDCVPPI 228
                       250       260       270
                ....*....|....*....|....*....|.
gi 22129725 272 IQIFNNL---VTPTINPLIYSLRNKDVKAAL 299
Cdd:cd14967 229 LYAVFFWlgyLNSALNPIIYALFNRDFRRAF 259
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
53-299 1.97e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 48.36  E-value: 1.97e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  53 PRLHTPMYFFLSNLSISDMGFCSTTAP-KMLSYLSGRGGGISFqGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLR 131
Cdd:cd14969  29 KKLRTPLNLFLLNLALADLLMSVVGYPlSFYSNLSGRWSFGDP-GCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLK 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 132 YTIIMNHRVCCVLAtGTWMSGCVHATiltcltfqLPYCGPSevSYyfcdMPAVLLLACE-DSSLAQRVGFTNVGLLSLIC 210
Cdd:cd14969 108 AFRLSKRRALILIA-FIWLYGLFWAL--------PPLFGWS--SY----VPEGGGTSCSvDWYSKDPNSLSYIVSLFVFC 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 211 FFL----IVVSYTRIGISISKIRSTEGRQRAFSTCSAHL-----TAIMCV---------YGP-----VIVIYLQPNPSPL 267
Cdd:cd14969 173 FFLplaiIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKkaekkVAKMVLvmivafliaWTPyavvsLYVSFGGESTIPP 252
                       250       260       270
                ....*....|....*....|....*....|..
gi 22129725 268 LSAIIQIFNNLVTPTINPLIYSLRNKDVKAAL 299
Cdd:cd14969 253 LLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
47-293 9.80e-06

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 46.11  E-value: 9.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  47 TAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAP-KMLSYLSGRGGGISFQGCVVQHFFYHCIGCVlCFLYTVMAYDRFVA 125
Cdd:cd15001  22 FVVARFRRMRSVTNVFLASLATADLLLLVFCVPlKTAEYFSPTWSLGAFLCKAVAYLQLLSFICS-VLTLTAISIERYYV 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 126 ICFPLR-YTIIMNHRVCCVlATGTWMSGCVHATILTCLTFQLPYCGPSEVSYYFCdmpavlLLACEDSSLAQRVGFTNVG 204
Cdd:cd15001 101 ILHPMKaKSFCTIGRARKV-ALLIWILSAILASPVLFGQGLVRYESENGVTVYHC------QKAWPSTLYSRLYVVYLAI 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 205 LLSLICFFLIVVSYTRigisiskirstEGRQRAFSTCSAHLTAIMCVYGPVIV-------IYLQPNPSPLLSAIIQIFNN 277
Cdd:cd15001 174 VIFFIPLIVMTFAYAR-----------DTRKQVIKMLISVVVLFAVCWGPLLIdnllvsfDVISTLHTQALKYMRIAFHL 242
                       250
                ....*....|....*...
gi 22129725 278 LV--TPTINPLIYSLRNK 293
Cdd:cd15001 243 LSyaNSCINPIIYAFMSK 260
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
26-236 1.63e-05

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 45.51  E-value: 1.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYH 105
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 106 CIGCVLCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATILTCLTFQLPYCGPSEVSyyfCDMPAVL 185
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQ---EEEICVL 157
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129725 186 LLACEDSSLAQRVGFTnvgLLSLICFFLIVVSYTRIGISISKIRSTEGRQR 236
Cdd:cd15012 158 DREMFNSKLYDTINFI---VWYLIPLLIMTVLYSKISIVLWKSSSIEARRK 205
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
48-152 2.22e-05

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 45.32  E-value: 2.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  48 AVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPkmLSYLSGRGGGISFQGCVvqhfFYHCIGCVLC----FLYTVMAYDRF 123
Cdd:cd14968  24 AVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCL----FMACLVLVLTqssiFSLLAIAIDRY 97
                        90       100
                ....*....|....*....|....*....
gi 22129725 124 VAICFPLRYTIIMNHRVCCVLATGTWMSG 152
Cdd:cd14968  98 LAIKIPLRYKSLVTGRRAWGAIAVCWVLS 126
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
26-227 8.93e-05

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 43.36  E-value: 8.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  26 VLLFLFSTLYACALLGNLLLLTAVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRG---GGI------SFQG 96
Cdd:cd15203   2 ILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNwpfGSIlcklvpSLQG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  97 CVVqhffyhcigCVLCFLYTVMAYDRFVAICFPLRYtiIMNHRVCCVLATGTWMSGC-------VHATILTCLTFQLPYC 169
Cdd:cd15203  82 VSI---------FVSTLTLTAIAIDRYQLIVYPTRP--RMSKRHALLIIALIWILSLllslplaIFQELSDVPIEILPYC 150
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129725 170 GpsevsyYFCDmpavlllacED--SSLAQRV-GFTNVGLLSLICFFLIVVSYTRIGISISK 227
Cdd:cd15203 151 G------YFCT---------ESwpSSSSRLIyTISVLVLQFVIPLLIISFCYFRISLKLRK 196
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
54-223 1.37e-04

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 42.80  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  54 RLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQG-CVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRY 132
Cdd:cd15394  30 KMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWVFGRFmCYFVFLMQPVTVYVSVFTLTAIAVDRYYVTVYPLRR 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 133 TIIMnhRVCCVLATGTWMSGCVHATiltcltfqlpycgPSEVSYYFCDMPAVLLLACE---DSSLAQRVGFTNVGLL--S 207
Cdd:cd15394 110 RISR--RTCAYIVAAIWLLSCGLAL-------------PAAAHTYYVEFKGLDFSICEefwFGQEKQRLAYACSTLLitY 174
                       170
                ....*....|....*.
gi 22129725 208 LICFFLIVVSYTRIGI 223
Cdd:cd15394 175 VLPLLAISLSYLRISV 190
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
48-149 1.48e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 42.48  E-value: 1.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  48 AVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHF-----FYHCIGCV--LCFLyTVMAY 120
Cdd:cd15103  24 AIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnvidSMICSSLLasICSL-LAIAV 102
                        90       100
                ....*....|....*....|....*....
gi 22129725 121 DRFVAICFPLRYTIIMNHRVCCVLATGTW 149
Cdd:cd15103 103 DRYITIFYALRYHSIMTVRRAGVIITAIW 131
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
49-225 8.99e-04

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 40.28  E-value: 8.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  49 VTSSPRLHTPMYFFLSNLSISDM---GFC-------STTAP--------KMLSYLsgrgggisfQGCVVqhffyhcigCV 110
Cdd:cd14993  25 VLRNKHMRTVTNYFLVNLAVADLlvsLFCmpltlleNVYRPwvfgevlcKAVPYL---------QGVSV---------SA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 111 LCFLYTVMAYDRFVAICFPLRYTIIMNHRVCCVLATGTWMSgcvhATILTCltfqlPYCGPSEVSYYFCDMPAVLLLA-C 189
Cdd:cd14993  87 SVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVI----AIIIML-----PLLVVYELEEIISSEPGTITIYiC 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 22129725 190 EDSSLAQRVGFTNVGLLSLICFFL----IVVSYTRIGISI 225
Cdd:cd14993 158 TEDWPSPELRKAYNVALFVVLYVLplliISVAYSLIGRRL 197
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
48-151 1.47e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 39.49  E-value: 1.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  48 AVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPK--MLSYLSGRGGGISFQGCVVQHFFYHCIGCV-----LCFLYtVMAY 120
Cdd:cd15352  24 AVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLEtiMIAVLNSGYLVISDQFIQHMDNVFDSMICIslvasICNLL-AIAV 102
                        90       100       110
                ....*....|....*....|....*....|.
gi 22129725 121 DRFVAICFPLRYTIIMNHRVCCVLATGTWMS 151
Cdd:cd15352 103 DRYVTIFYALRYHSIMTVRKALVLIAVIWVV 133
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
48-150 2.31e-03

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 39.24  E-value: 2.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  48 AVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKML-SYLSGRgGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAI 126
Cdd:cd15083  24 AFCRFKSLRTPANYLIINLAISDFLMCILNCPLMViSSFSGR-WIFGKTGCDMYGFSGGLFGIMSINTLAAIAVDRYLVI 102
                        90       100
                ....*....|....*....|....
gi 22129725 127 CFPLRYTIIMNHRVCCVLATGTWM 150
Cdd:cd15083 103 TRPMKASVRISHRRALIVIAVVWL 126
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
48-159 2.54e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 39.01  E-value: 2.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  48 AVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHF-----FYHCIGCV--LCFLYTVmAY 120
Cdd:cd15351  24 AIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidTMICSSVVssLSFLGAI-AV 102
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 22129725 121 DRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATIL 159
Cdd:cd15351 103 DRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLF 141
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
53-293 2.70e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 38.68  E-value: 2.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  53 PRLHTPMYFFLSNLSISD--MGFCSTTAPKMLSYLSGRGGGISFqgCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPL 130
Cdd:cd15085  29 PQLRNPINIFILNLSFSDlmMALCGTTIVTVTNYEGYFYLGDAF--CIFQGFAVNYFGIVSLWSLTLLAYERYNVVCKPM 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 131 RyTIIMNHRVCCVLATGTWmsgcvhatiLTCLTFQL-PYCGPSevSYYFCDMPAVLLLACEDSSLAQrvgFTNVGLLSLI 209
Cdd:cd15085 107 G-GLKLSTKRGYQGLLFIW---------LFCLFWAVaPLFGWS--SYGPEGVQTSCSIGWEERSWSN---YSYLILYFLM 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 210 CFFL----IVVSYTRIGISISKIR----------STEGRQRAFSTCSAHLTAIMCVYGP------VIVIYLQPNPSPLLS 269
Cdd:cd15085 172 CFVIpvaiIGFSYGNVLRSLHKLNkkieqqggknCPEEEERAVIMVLAMVIAFLICWLPytvfalIVVVNPELSISPLAA 251
                       250       260
                ....*....|....*....|....
gi 22129725 270 AIIQIFNNlVTPTINPLIYSLRNK 293
Cdd:cd15085 252 TMPTYFAK-TSPVYNPIIYIFLNK 274
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
57-299 2.70e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 38.89  E-value: 2.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  57 TPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFY--HCIGCVLCFLytVMAYDRFVAICFPLRYTI 134
Cdd:cd15104  33 TKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVitSCAASVLSLA--AIAFDRYLALKQPLRYKQ 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 135 IMNHRVCCVLATGTWM-SGCVHATILTCLTFQLPYCGPSEVSYYFCDMPAVLLLACedsslaqrVGFTNVGLLSLICFFL 213
Cdd:cd15104 111 IMTGKSAGALIAGLWLySGLIGFLPLISPQFQQTSYKGKCSFFAAFHPRVLLVLSC--------MVFFPALLLFVFCYCD 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 214 IVVSYTRIGISISKIRSTEGRQRAFSTCSAHLTAIMCVYGPVIVIYLQPNPSpLLSAIIQIFNNLVTPT----------- 282
Cdd:cd15104 183 ILKIARVHSRAIYKVEHALARQIHPRRTLSDFKAARTVAVLIGCFLLSWLPF-QITGLVQALCDECKLYdvledylwllg 261
                       250       260
                ....*....|....*....|..
gi 22129725 283 -----INPLIYSLRNKDVKAAL 299
Cdd:cd15104 262 lcnslLNPWIYAFWQKEVRRAL 283
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
54-150 4.06e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 38.40  E-value: 4.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  54 RLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHC-IGCVLCFLyTVMAYDRFVAICFPLRY 132
Cdd:cd14982  30 KKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYInMYGSILFL-TCISVDRYLAVVHPLKS 108
                        90
                ....*....|....*...
gi 22129725 133 TIIMNHRVCCVLATGTWM 150
Cdd:cd14982 109 RRLRRKRYAVGVCAGVWI 126
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
49-223 5.25e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 38.04  E-value: 5.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  49 VTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICF 128
Cdd:cd15390  25 VLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAASVFTLMAISIDRYIAIVH 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 129 PLRYTiiMNHRVCCVLATGTWMSGCVHAT--ILTCLTFQLPYCGPSEVSYYFCDMPavlllacEDSSLAQRVGFtNVGLL 206
Cdd:cd15390 105 PLRPR--LSRRTTKIAIAVIWLASFLLALpqLLYSTTETYYYYTGSERTVCFIAWP-------DGPNSLQDFVY-NIVLF 174
                       170       180
                ....*....|....*....|
gi 22129725 207 SLICFFLIVV---SYTRIGI 223
Cdd:cd15390 175 VVTYFLPLIImavAYTRVGV 194
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
55-290 5.52e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 38.08  E-value: 5.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  55 LHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGR-----GGGIsfqgCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFP 129
Cdd:cd15134  31 MHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQypwvfGEVF----CKLRAFLSEMSSYASVLTITAFSVERYLAICHP 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 130 LRYTIIMNHRVCCVLATGTWMSGCVHAtiltcltfqLPYCGPSEVSYYFcdMPAVLLLACEDSS----LAQRVGFTNVGL 205
Cdd:cd15134 107 LRSHTMSKLSRAIRIIIAIWIIAFVCA---------LPFAIQTRIVYLE--YPPTSGEALEESAfcamLNEIPPITPVFQ 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 206 LSLICFFL-----IVVSYTRIGISISK--------IRSTEGRQR----------------AFSTCSA--HLTAIMCVYGP 254
Cdd:cd15134 176 LSTFLFFIipmiaIIVLYVLIGLQLRRstllrrgqRSVSGGRRSsqsrrtvlrmlvavvvAFFICWApfHAQRLLTVYAK 255
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129725 255 ViviyLQPNPSPLLSAIIQI--FNNLVTPTINPLIYSL 290
Cdd:cd15134 256 N----MTPPYLFINRILFYIsgVLYYVSSTVNPILYNV 289
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
48-149 7.13e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 37.61  E-value: 7.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  48 AVTSSPRLHTPMYFFLSNLSISDMGFCSTTAPKMLSYLSGRGGGISFQGCVVQHF-----FYHCIGCV--LCFLYTVmAY 120
Cdd:cd15354  24 AIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIdnvfdSLICISVVasMCSLLAI-AV 102
                        90       100
                ....*....|....*....|....*....
gi 22129725 121 DRFVAICFPLRYTIIMNHRVCCVLATGTW 149
Cdd:cd15354 103 DRYVTIFYALRYHNIMTVRRAGIIIACIW 131
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
57-139 7.75e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 37.61  E-value: 7.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  57 TPMYFFLSNLSISDM-GFCSTTAPKMLSYLSGRGGGISFQGCVVQHFFYHCIGCVLCFLYTVMAYDRFVAICFPLRYTII 135
Cdd:cd14981  35 SVFYRLVAGLAITDLlGILLTSPVVLAVYASNFEWDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSH 114

                ....
gi 22129725 136 MNHR 139
Cdd:cd14981 115 VKKR 118
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
48-299 9.14e-03

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 37.27  E-value: 9.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725  48 AVTSSPRLHTPMYFFLSNLSISDM--GFCSTtapkmlsYLSGRGGGISFQGCVVQHFFYHCIGCV-----LCFLYtVMAY 120
Cdd:cd14972  22 AIIKNRRLHKPMYILIANLAAADLlaGIAFV-------FTFLSVLLVSLTPSPATWLLRKGSLVLsllasAYSLL-AIAV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 121 DRFVAICFPLRYTIIMNHRVCCVLATGTWMSGCVHATiltcltfqLPYCGPSEVsyyFCDMPAVLLLACEDSslaqrvgf 200
Cdd:cd14972  94 DRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGWNCV---LCDQESCSPLGPGLP-------- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129725 201 TNVGLLSLICFFL----IVVSYTRIGISI----SKIR----STEGRQRAFSTCSAHLTAIMCV-----YGPVIVIYLQPN 263
Cdd:cd14972 155 KSYLVLILVFFFIalviIVFLYVRIFWCLwrhaNAIAarqeAAVPAQPSTSRKLAKTVVIVLGvflvcWLPLLILLVLDV 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 22129725 264 PSPLLSAIIQIFNNLVTPT-----INPLIYSLRNKDVKAAL 299
Cdd:cd14972 235 LCPSVCDIQAVFYYFLVLAllnsaINPIIYAFRLKEMRRAV 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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