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Conserved domains on  [gi|22122493|ref|NP_666130|]
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folliculin [Mus musculus]

Protein Classification

folliculin domain-containing protein( domain architecture ID 11189898)

folliculin domain-containing protein such as human folliculin that regulates transferrin receptor 1 transport and iron homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Folliculin_C pfam16692
Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine ...
 346-566 4.43e-114

Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine nucleotide exchange factor (GEF) activity.


:

Pssm-ID: 465236  Cd Length: 226  Bit Score: 338.63  E-value: 4.43e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   346 FKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLVHSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPPVP 425
Cdd:pfam16692   3 FTSLRHLRKVLGEDSFRALAWHVVIGNQVIWRGQNPSLVTSAFNVLKDLLPVGCVRVCPYSDQYEETYKCNILGLSPAVV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   426 IPAHVLASEFVVVVEVHTATRS-----NLHPAGCEDDQSLSKYEFVVTSGSPVAadRVGPTILNKIEAALTNQNLSVDVV 500
Cdd:pfam16692  83 IPRHVVSSEFFVLVDIHYYDESkepedIDHPNRSVDDDALNTIEFTFSGPCTLP--EKGPSTLNKAEVAIYNESLSPEVV 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22122493   501 DQCLICLKEEWMNKVKVLFKFTKVDSRPKEDTQKLLSVLGASEEDNVKLLKFWMTGLSKTYKSHLM 566
Cdd:pfam16692 161 RHCLICLKEEWMNKVKVLYKFTKIDNREKEDTKRLLQFLGAIEEDDVRLLMFWMTGLSKQFKSHLM 226
Folliculin pfam11704
Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this ...
 106-265 1.30e-78

Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this family functions in the regulated delivery of Gap1p (a general amino acid permease) to the cell surface, perhaps as a component of a post-Golgi secretory-vesicle coat complex. Birt-Hogg-Dube (BHD)4 syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, lung cysts, spontaneous pneumothorax, and renal cell carcinoma. Folliculin is the protein from the BHD4 gene and is found to have no significant homology to any other human proteins. It is expressed in most tissues. These same symptoms also occur in TSC or tuberous sclerosis complex, suggesting that the same pathway is involved, and it is likely that the target is the down-stream Tor2 - an essential gene. Folliculin appears to bind Tor2, and down-regulation of Tor2 activity leads to up-regulation of nitrogen responsive genes including membrane transporters and amino acid permeases.


:

Pssm-ID: 463323  Cd Length: 163  Bit Score: 245.18  E-value: 1.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   106 YVSHQHPNHPQLFSIVRQACVRSLSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIIAIMMDRIYLINS 185
Cdd:pfam11704   1 YVSTQYPSSPERYSLLRQACVRSLSCETLPGDGGPIFFGDSIRGYTLAYIFRLPDPNARGFERRYSLIALSDDKRLLLNN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   186 WPFLLGRIRGIISELQAKAFKVFEAEQFGCpQRAQRMNTAFTP----FLHQRNGNAARSLTSLTSDDNLWACLHTSFAWL 261
Cdd:pfam11704  81 WPFITSAFRKLISEIQQKAEKVLEREQKQC-QSRRRMGSGFSLdpgnYLRRSKSKLARSLAELTGDPDIFVELHAWFVWL 159


                  ....
gi 22122493   262 LKAC 265
Cdd:pfam11704 160 LKAL 163
 
Name Accession Description Interval E-value
Folliculin_C pfam16692
Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine ...
 346-566 4.43e-114

Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine nucleotide exchange factor (GEF) activity.


Pssm-ID: 465236  Cd Length: 226  Bit Score: 338.63  E-value: 4.43e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   346 FKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLVHSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPPVP 425
Cdd:pfam16692   3 FTSLRHLRKVLGEDSFRALAWHVVIGNQVIWRGQNPSLVTSAFNVLKDLLPVGCVRVCPYSDQYEETYKCNILGLSPAVV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   426 IPAHVLASEFVVVVEVHTATRS-----NLHPAGCEDDQSLSKYEFVVTSGSPVAadRVGPTILNKIEAALTNQNLSVDVV 500
Cdd:pfam16692  83 IPRHVVSSEFFVLVDIHYYDESkepedIDHPNRSVDDDALNTIEFTFSGPCTLP--EKGPSTLNKAEVAIYNESLSPEVV 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22122493   501 DQCLICLKEEWMNKVKVLFKFTKVDSRPKEDTQKLLSVLGASEEDNVKLLKFWMTGLSKTYKSHLM 566
Cdd:pfam16692 161 RHCLICLKEEWMNKVKVLYKFTKIDNREKEDTKRLLQFLGAIEEDDVRLLMFWMTGLSKQFKSHLM 226
Folliculin pfam11704
Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this ...
 106-265 1.30e-78

Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this family functions in the regulated delivery of Gap1p (a general amino acid permease) to the cell surface, perhaps as a component of a post-Golgi secretory-vesicle coat complex. Birt-Hogg-Dube (BHD)4 syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, lung cysts, spontaneous pneumothorax, and renal cell carcinoma. Folliculin is the protein from the BHD4 gene and is found to have no significant homology to any other human proteins. It is expressed in most tissues. These same symptoms also occur in TSC or tuberous sclerosis complex, suggesting that the same pathway is involved, and it is likely that the target is the down-stream Tor2 - an essential gene. Folliculin appears to bind Tor2, and down-regulation of Tor2 activity leads to up-regulation of nitrogen responsive genes including membrane transporters and amino acid permeases.


Pssm-ID: 463323  Cd Length: 163  Bit Score: 245.18  E-value: 1.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   106 YVSHQHPNHPQLFSIVRQACVRSLSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIIAIMMDRIYLINS 185
Cdd:pfam11704   1 YVSTQYPSSPERYSLLRQACVRSLSCETLPGDGGPIFFGDSIRGYTLAYIFRLPDPNARGFERRYSLIALSDDKRLLLNN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   186 WPFLLGRIRGIISELQAKAFKVFEAEQFGCpQRAQRMNTAFTP----FLHQRNGNAARSLTSLTSDDNLWACLHTSFAWL 261
Cdd:pfam11704  81 WPFITSAFRKLISEIQQKAEKVLEREQKQC-QSRRRMGSGFSLdpgnYLRRSKSKLARSLAELTGDPDIFVELHAWFVWL 159


                  ....
gi 22122493   262 LKAC 265
Cdd:pfam11704 160 LKAL 163
 
Name Accession Description Interval E-value
Folliculin_C pfam16692
Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine ...
 346-566 4.43e-114

Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine nucleotide exchange factor (GEF) activity.


Pssm-ID: 465236  Cd Length: 226  Bit Score: 338.63  E-value: 4.43e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   346 FKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLVHSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPPVP 425
Cdd:pfam16692   3 FTSLRHLRKVLGEDSFRALAWHVVIGNQVIWRGQNPSLVTSAFNVLKDLLPVGCVRVCPYSDQYEETYKCNILGLSPAVV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   426 IPAHVLASEFVVVVEVHTATRS-----NLHPAGCEDDQSLSKYEFVVTSGSPVAadRVGPTILNKIEAALTNQNLSVDVV 500
Cdd:pfam16692  83 IPRHVVSSEFFVLVDIHYYDESkepedIDHPNRSVDDDALNTIEFTFSGPCTLP--EKGPSTLNKAEVAIYNESLSPEVV 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22122493   501 DQCLICLKEEWMNKVKVLFKFTKVDSRPKEDTQKLLSVLGASEEDNVKLLKFWMTGLSKTYKSHLM 566
Cdd:pfam16692 161 RHCLICLKEEWMNKVKVLYKFTKIDNREKEDTKRLLQFLGAIEEDDVRLLMFWMTGLSKQFKSHLM 226
Folliculin pfam11704
Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this ...
 106-265 1.30e-78

Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this family functions in the regulated delivery of Gap1p (a general amino acid permease) to the cell surface, perhaps as a component of a post-Golgi secretory-vesicle coat complex. Birt-Hogg-Dube (BHD)4 syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, lung cysts, spontaneous pneumothorax, and renal cell carcinoma. Folliculin is the protein from the BHD4 gene and is found to have no significant homology to any other human proteins. It is expressed in most tissues. These same symptoms also occur in TSC or tuberous sclerosis complex, suggesting that the same pathway is involved, and it is likely that the target is the down-stream Tor2 - an essential gene. Folliculin appears to bind Tor2, and down-regulation of Tor2 activity leads to up-regulation of nitrogen responsive genes including membrane transporters and amino acid permeases.


Pssm-ID: 463323  Cd Length: 163  Bit Score: 245.18  E-value: 1.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   106 YVSHQHPNHPQLFSIVRQACVRSLSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIIAIMMDRIYLINS 185
Cdd:pfam11704   1 YVSTQYPSSPERYSLLRQACVRSLSCETLPGDGGPIFFGDSIRGYTLAYIFRLPDPNARGFERRYSLIALSDDKRLLLNN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122493   186 WPFLLGRIRGIISELQAKAFKVFEAEQFGCpQRAQRMNTAFTP----FLHQRNGNAARSLTSLTSDDNLWACLHTSFAWL 261
Cdd:pfam11704  81 WPFITSAFRKLISEIQQKAEKVLEREQKQC-QSRRRMGSGFSLdpgnYLRRSKSKLARSLAELTGDPDIFVELHAWFVWL 159


                  ....
gi 22122493   262 LKAC 265
Cdd:pfam11704 160 LKAL 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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