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Conserved domains on  [gi|21703872|ref|NP_663412|]
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CMRF35-like molecule 5 precursor [Mus musculus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 23-124 2.75e-32

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 112.88  E-value: 2.75e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703872  23 TGPEEVSGQEQGSLTVQCRYSSYWKGYKKYWCRGVPqRSCDILVetdKSEQLVKKNRVSIRDNQRDFIFTVTMEDLRMSD 102
Cdd:cd05716   2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS-EGCQTLV---SSEGVVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|...
gi 21703872 103 AGIYWCGITKGG-PDPMFKVNVN 124
Cdd:cd05716  78 AGWYWCGVGDDGdRGLTVQVKLV 100
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 23-124 2.75e-32

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 112.88  E-value: 2.75e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703872  23 TGPEEVSGQEQGSLTVQCRYSSYWKGYKKYWCRGVPqRSCDILVetdKSEQLVKKNRVSIRDNQRDFIFTVTMEDLRMSD 102
Cdd:cd05716   2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS-EGCQTLV---SSEGVVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|...
gi 21703872 103 AGIYWCGITKGG-PDPMFKVNVN 124
Cdd:cd05716  78 AGWYWCGVGDDGdRGLTVQVKLV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-120 7.00e-20

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 80.97  E-value: 7.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703872    23 TGPEEVSGQEQGSLTVQCRYSSYW--KGYKKYWCRGVP--QRSCDILVETDKSEQLVKKNRVSIRDNQRDFIFTVTMEDL 98
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQPPgkGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|..
gi 21703872    99 RMSDAGIYWCGITKGGPDPMFK 120
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGK 102
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-125 2.57e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 2.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703872     25 PEEVSGQEQGSLTVQCRYSSYWKgYKKYWCRgvpqrscdilvetDKSEQLVKKNRVSIRDNqrDFIFTVTMEDLRMSDAG 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP-PEVTWYK-------------QGGKLLAESGRFSVSRS--GSTSTLTISNVTPEDSG 64

                           90       100
                   ....*....|....*....|.
gi 21703872    105 IYWCGITKGGPDPMFKVNVNI 125
Cdd:smart00410  65 TYTCAATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 23-124 2.75e-32

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 112.88  E-value: 2.75e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703872  23 TGPEEVSGQEQGSLTVQCRYSSYWKGYKKYWCRGVPqRSCDILVetdKSEQLVKKNRVSIRDNQRDFIFTVTMEDLRMSD 102
Cdd:cd05716   2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS-EGCQTLV---SSEGVVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|...
gi 21703872 103 AGIYWCGITKGG-PDPMFKVNVN 124
Cdd:cd05716  78 AGWYWCGVGDDGdRGLTVQVKLV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-120 7.00e-20

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 80.97  E-value: 7.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703872    23 TGPEEVSGQEQGSLTVQCRYSSYW--KGYKKYWCRGVP--QRSCDILVETDKSEQLVKKNRVSIRDNQRDFIFTVTMEDL 98
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQPPgkGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|..
gi 21703872    99 RMSDAGIYWCGITKGGPDPMFK 120
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGK 102
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-125 2.57e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 2.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703872     25 PEEVSGQEQGSLTVQCRYSSYWKgYKKYWCRgvpqrscdilvetDKSEQLVKKNRVSIRDNqrDFIFTVTMEDLRMSDAG 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP-PEVTWYK-------------QGGKLLAESGRFSVSRS--GSTSTLTISNVTPEDSG 64

                           90       100
                   ....*....|....*....|.
gi 21703872    105 IYWCGITKGGPDPMFKVNVNI 125
Cdd:smart00410  65 TYTCAATNSSGSASSGTTLTV 85
IGv smart00406
Immunoglobulin V-Type;
35-108 1.07e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.98  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703872     35 SLTVQCRYSSY-WKGYKKYWCRGVPQRSCDILVE-----TDKSEQLVKkNRVSIRDNQRDFIFTVTMEDLRMSDAGIYWC 108
Cdd:smart00406   1 SVTLSCKFSGStFSSYYVSWVRQPPGKGLEWLGYigsngSSYYQESYK-GRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 25-108 2.85e-03

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 36.16  E-value: 2.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703872  25 PEEVSGQEQGSLTVQCRYSSYWKGYKKYWCRGVPQRSCDILV---ETDKSEQLVKKNRVSI-RDNQRDFIFTVTmeDLRM 100
Cdd:cd00099   5 PRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKPGQGPEFLIylsSSKGKTKGGVPGRFSGsRDGTSSFSLTIS--NLQP 82


                ....*...
gi 21703872 101 SDAGIYWC 108
Cdd:cd00099  83 EDSGTYYC 90
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 21-115 8.80e-03

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 35.06  E-value: 8.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703872  21 SVTGPEEVSGQEQGSLTVQCRYSSYWKGYKK-----YWCRGVPQRSCDILVETDKSEQLVKKnrvSIRDNqrdFIF---- 91
Cdd:cd05712   2 GLQMPKSVTVQEGLCVLIPCSFSYPADYWVSnpvhgYWYRGGPYPKYRPPVATNNRTREVHE---STQGR---FRLlgdp 75

                        90       100
                ....*....|....*....|....*....
gi 21703872  92 -----TVTMEDLRMSDAGIYWCGITKGGP 115
Cdd:cd05712  76 gkkncSLSISDARPEDSGKYFFRVERGDS 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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