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Conserved domains on  [gi|145279222|ref|NP_653269|]
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cilia- and flagella-associated protein 251 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 606-920 3.58e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 3.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  606 KDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVfEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSleNES 685
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLET--GEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  686 PEPFKYSRTSVTHISFSHDSQYMATADRSFTVavymlvvrngqRVWE-----YLARLRSHRKSIRSLLFgvylDSNEPRL 760
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI-----------KVWDvetgkCLTTLRGHTDWVNSVAF----SPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  761 LSLGTDRLLIEYDL--LRSYKDHLevldiHHTDQGcypTCMVWYPPLTRelfLLICNSGYKVKLFNATTKMCRKTLLGPA 838
Cdd:cd00200   151 ASSSQDGTIKLWDLrtGKCVATLT-----GHTGEV---NSVAFSPDGEK---LLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  839 YgspieqtqvlPVRSMAELQKRYLVFI-NRDKVgLQILPVD-GNPHKTsaIVCHPNGVAGMAVSYDGCYAFTaGGHDRSV 916
Cdd:cd00200   220 N----------GVNSVAFSPDGYLLASgSEDGT-IRVWDLRtGECVQT--LSGHTNSVTSLAWSPDGKRLAS-GSADGTI 285


                  ....
gi 145279222  917 VQWK 920
Cdd:cd00200   286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
295-678 2.30e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 2.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  295 LQGHANIISCLCVSEDRRWIATAdkGPDCLVIIWDSFTGIPVHTIFdscPEGNGIMAMAMTHDAKYLATISDAevQKVCI 374
Cdd:COG2319    74 LLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLT---GHTGAVRSVAFSPDGKTLASGSAD--GTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  375 WKwtlaVETPACTLELPTEYGVQNYVTFNPtNNKELVSNSKTRAIYYaWYEERDTLAHsaplltekTFNKLVGKFSQSIF 454
Cdd:COG2319   147 WD----LATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRL-WDLATGKLLR--------TLTGHTGAVRSVAF 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  455 HLNLTQILSATMEGKLVVWDIHRPpssastflgfpyikpcKLVHLQKEGITVLTTID-----SYIVTGDIKGNIKFYD-H 528
Cdd:COG2319   213 SPDGKLLASGSADGTVRLWDLATG----------------KLLRTLTGHSGSVRSVAfspdgRLLASGSADGTVRLWDlA 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  529 TLSIVNWYSHLKlGAIRTLSFSktpatppteksnypPDctlkGDLFVlrnfiIGTSDAAVYHLTTDGTKLEKLFVEPKDA 608
Cdd:COG2319   277 TGELLRTLTGHS-GGVNSVAFS--------------PD----GKLLA-----SGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145279222  609 ICAISCHPYQPLIAIGSICGMIKVWNYENKQYLfsRVFEKGLG-VQSLTYNPEGALLGAGFTEGTVYILDA 678
Cdd:COG2319   333 VRSVAFSPDGKTLASGSDDGTVRLWDLATGELL--RTLTGHTGaVTSVAFSPDGRTLASGSADGTVRLWDL 401
PTZ00183 super family cl33171
centrin; Provisional
 986-1089 4.56e-03

centrin; Provisional


The actual alignment was detected with superfamily member PTZ00183:

Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 38.90  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  986 ELPFVMRAIGFYPSEEKIDDIFNEIKfgeyvdtgKLID-KINLPDFLK---VYLNHKppfgNTMSGIHKSFEVLGyTNSK 1061
Cdd:PTZ00183   38 ELKVAMRSLGFEPKKEEIKQMIADVD--------KDGSgKIDFEEFLDimtKKLGER----DPREEILKAFRLFD-DDKT 104

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 145279222 1062 GK---KAIRRedflrllVTK--GEHMTEEE---MLD 1089
Cdd:PTZ00183  105 GKislKNLKR-------VAKelGETITDEElqeMID 133
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 606-920 3.58e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 3.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  606 KDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVfEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSleNES 685
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLET--GEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  686 PEPFKYSRTSVTHISFSHDSQYMATADRSFTVavymlvvrngqRVWE-----YLARLRSHRKSIRSLLFgvylDSNEPRL 760
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI-----------KVWDvetgkCLTTLRGHTDWVNSVAF----SPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  761 LSLGTDRLLIEYDL--LRSYKDHLevldiHHTDQGcypTCMVWYPPLTRelfLLICNSGYKVKLFNATTKMCRKTLLGPA 838
Cdd:cd00200   151 ASSSQDGTIKLWDLrtGKCVATLT-----GHTGEV---NSVAFSPDGEK---LLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  839 YgspieqtqvlPVRSMAELQKRYLVFI-NRDKVgLQILPVD-GNPHKTsaIVCHPNGVAGMAVSYDGCYAFTaGGHDRSV 916
Cdd:cd00200   220 N----------GVNSVAFSPDGYLLASgSEDGT-IRVWDLRtGECVQT--LSGHTNSVTSLAWSPDGKRLAS-GSADGTI 285


                  ....
gi 145279222  917 VQWK 920
Cdd:cd00200   286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
580-919 1.86e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 1.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  580 IIGTSDAAVYHLTTDGTKLEKLFVEPKDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVFEKGlGVQSLTYNP 659
Cdd:COG2319    52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG-AVRSVAFSP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  660 EGALLGAGFTEGTVYILDAMSleNESPEPFKYSRTSVTHISFSHDSQYMATADRSFTVAVYmlVVRNGQRvweyLARLRS 739
Cdd:COG2319   131 DGKTLASGSADGTVRLWDLAT--GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATGKL----LRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  740 HRKSIRSLLFgvylDSNEPRLLSLGTDRLLIEYDL-----LRSYKDH-LEVLDIHHTDQGcyptcmvwyppltreLFLLI 813
Cdd:COG2319   203 HTGAVRSVAF----SPDGKLLASGSADGTVRLWDLatgklLRTLTGHsGSVRSVAFSPDG---------------RLLAS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  814 CNSGYKVKLFNATTKMCRKTLLGPAYgspieqtqvlPVRSMAel-qkRYLVFINRDKVgLQILPVDgNPHKTSAIVCHPN 892
Cdd:COG2319   264 GSADGTVRLWDLATGELLRTLTGHSG----------GVNSVAfspdgKLLASGSDDGT-VRLWDLA-TGKLLRTLTGHTG 331

                         330       340
                  ....*....|....*....|....*..
gi 145279222  893 GVAGMAVSYDGCYAFTaGGHDRSVVQW 919
Cdd:COG2319   332 AVRSVAFSPDGKTLAS-GSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
295-678 2.30e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 2.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  295 LQGHANIISCLCVSEDRRWIATAdkGPDCLVIIWDSFTGIPVHTIFdscPEGNGIMAMAMTHDAKYLATISDAevQKVCI 374
Cdd:COG2319    74 LLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLT---GHTGAVRSVAFSPDGKTLASGSAD--GTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  375 WKwtlaVETPACTLELPTEYGVQNYVTFNPtNNKELVSNSKTRAIYYaWYEERDTLAHsaplltekTFNKLVGKFSQSIF 454
Cdd:COG2319   147 WD----LATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRL-WDLATGKLLR--------TLTGHTGAVRSVAF 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  455 HLNLTQILSATMEGKLVVWDIHRPpssastflgfpyikpcKLVHLQKEGITVLTTID-----SYIVTGDIKGNIKFYD-H 528
Cdd:COG2319   213 SPDGKLLASGSADGTVRLWDLATG----------------KLLRTLTGHSGSVRSVAfspdgRLLASGSADGTVRLWDlA 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  529 TLSIVNWYSHLKlGAIRTLSFSktpatppteksnypPDctlkGDLFVlrnfiIGTSDAAVYHLTTDGTKLEKLFVEPKDA 608
Cdd:COG2319   277 TGELLRTLTGHS-GGVNSVAFS--------------PD----GKLLA-----SGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145279222  609 ICAISCHPYQPLIAIGSICGMIKVWNYENKQYLfsRVFEKGLG-VQSLTYNPEGALLGAGFTEGTVYILDA 678
Cdd:COG2319   333 VRSVAFSPDGKTLASGSDDGTVRLWDLATGELL--RTLTGHTGaVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 294-675 1.88e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  294 HLQGHANIISCLCVSEDRRWIATAdkGPDCLVIIWDSFTGIP-----VHTIFDSCpegngIMAMAmthDAKYLATISDAe 368
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELlrtlkGHTGPVRD-----VAASA---DGTYLASGSSD- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  369 vQKVCIWKWtlavETPACTLELpteYGVQNYVT---FNPTNnkelvsnsktraiyyawyeerdtlahsaplltektfnkl 445
Cdd:cd00200    73 -KTIRLWDL----ETGECVRTL---TGHTSYVSsvaFSPDG--------------------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  446 vgkfsqsifhlnltQILSATME-GKLVVWDIhRPPSSASTFLGFPyiKPCKLVHLQKEGitvlttidSYIVTGDIKGNIK 524
Cdd:cd00200   106 --------------RILSSSSRdKTIKVWDV-ETGKCLTTLRGHT--DWVNSVAFSPDG--------TFVASSSQDGTIK 160

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  525 FYD-HTLSIVNWYSHLKlGAIRTLSFSktpatppteksnypPDctlkgdlfvLRNFIIGTSDAAVYHLTTDGTKLEKLFV 603
Cdd:cd00200   161 LWDlRTGKCVATLTGHT-GEVNSVAFS--------------PD---------GEKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145279222  604 EPKDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSrVFEKGLGVQSLTYNPEGALLGAGFTEGTVYI 675
Cdd:cd00200   217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT-LSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 pfam00400
WD domain, G-beta repeat;
292-329 2.35e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.35e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 145279222   292 QYHLQGHANIISCLCVSEDRRWIATADKgpDCLVIIWD 329
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSD--DGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 295-329 3.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.17e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 145279222    295 LQGHANIISCLCVSEDRRWIATADKgpDCLVIIWD 329
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLWD 40
PTZ00183 PTZ00183
centrin; Provisional
 986-1089 4.56e-03

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 38.90  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  986 ELPFVMRAIGFYPSEEKIDDIFNEIKfgeyvdtgKLID-KINLPDFLK---VYLNHKppfgNTMSGIHKSFEVLGyTNSK 1061
Cdd:PTZ00183   38 ELKVAMRSLGFEPKKEEIKQMIADVD--------KDGSgKIDFEEFLDimtKKLGER----DPREEILKAFRLFD-DDKT 104

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 145279222 1062 GK---KAIRRedflrllVTK--GEHMTEEE---MLD 1089
Cdd:PTZ00183  105 GKislKNLKR-------VAKelGETITDEElqeMID 133
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 606-920 3.58e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 3.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  606 KDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVfEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSleNES 685
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLET--GEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  686 PEPFKYSRTSVTHISFSHDSQYMATADRSFTVavymlvvrngqRVWE-----YLARLRSHRKSIRSLLFgvylDSNEPRL 760
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI-----------KVWDvetgkCLTTLRGHTDWVNSVAF----SPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  761 LSLGTDRLLIEYDL--LRSYKDHLevldiHHTDQGcypTCMVWYPPLTRelfLLICNSGYKVKLFNATTKMCRKTLLGPA 838
Cdd:cd00200   151 ASSSQDGTIKLWDLrtGKCVATLT-----GHTGEV---NSVAFSPDGEK---LLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  839 YgspieqtqvlPVRSMAELQKRYLVFI-NRDKVgLQILPVD-GNPHKTsaIVCHPNGVAGMAVSYDGCYAFTaGGHDRSV 916
Cdd:cd00200   220 N----------GVNSVAFSPDGYLLASgSEDGT-IRVWDLRtGECVQT--LSGHTNSVTSLAWSPDGKRLAS-GSADGTI 285


                  ....
gi 145279222  917 VQWK 920
Cdd:cd00200   286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
580-919 1.86e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 1.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  580 IIGTSDAAVYHLTTDGTKLEKLFVEPKDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVFEKGlGVQSLTYNP 659
Cdd:COG2319    52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG-AVRSVAFSP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  660 EGALLGAGFTEGTVYILDAMSleNESPEPFKYSRTSVTHISFSHDSQYMATADRSFTVAVYmlVVRNGQRvweyLARLRS 739
Cdd:COG2319   131 DGKTLASGSADGTVRLWDLAT--GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATGKL----LRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  740 HRKSIRSLLFgvylDSNEPRLLSLGTDRLLIEYDL-----LRSYKDH-LEVLDIHHTDQGcyptcmvwyppltreLFLLI 813
Cdd:COG2319   203 HTGAVRSVAF----SPDGKLLASGSADGTVRLWDLatgklLRTLTGHsGSVRSVAFSPDG---------------RLLAS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  814 CNSGYKVKLFNATTKMCRKTLLGPAYgspieqtqvlPVRSMAel-qkRYLVFINRDKVgLQILPVDgNPHKTSAIVCHPN 892
Cdd:COG2319   264 GSADGTVRLWDLATGELLRTLTGHSG----------GVNSVAfspdgKLLASGSDDGT-VRLWDLA-TGKLLRTLTGHTG 331

                         330       340
                  ....*....|....*....|....*..
gi 145279222  893 GVAGMAVSYDGCYAFTaGGHDRSVVQW 919
Cdd:COG2319   332 AVRSVAFSPDGKTLAS-GSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
295-678 2.30e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 2.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  295 LQGHANIISCLCVSEDRRWIATAdkGPDCLVIIWDSFTGIPVHTIFdscPEGNGIMAMAMTHDAKYLATISDAevQKVCI 374
Cdd:COG2319    74 LLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLT---GHTGAVRSVAFSPDGKTLASGSAD--GTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  375 WKwtlaVETPACTLELPTEYGVQNYVTFNPtNNKELVSNSKTRAIYYaWYEERDTLAHsaplltekTFNKLVGKFSQSIF 454
Cdd:COG2319   147 WD----LATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRL-WDLATGKLLR--------TLTGHTGAVRSVAF 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  455 HLNLTQILSATMEGKLVVWDIHRPpssastflgfpyikpcKLVHLQKEGITVLTTID-----SYIVTGDIKGNIKFYD-H 528
Cdd:COG2319   213 SPDGKLLASGSADGTVRLWDLATG----------------KLLRTLTGHSGSVRSVAfspdgRLLASGSADGTVRLWDlA 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  529 TLSIVNWYSHLKlGAIRTLSFSktpatppteksnypPDctlkGDLFVlrnfiIGTSDAAVYHLTTDGTKLEKLFVEPKDA 608
Cdd:COG2319   277 TGELLRTLTGHS-GGVNSVAFS--------------PD----GKLLA-----SGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145279222  609 ICAISCHPYQPLIAIGSICGMIKVWNYENKQYLfsRVFEKGLG-VQSLTYNPEGALLGAGFTEGTVYILDA 678
Cdd:COG2319   333 VRSVAFSPDGKTLASGSDDGTVRLWDLATGELL--RTLTGHTGaVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
280-476 4.06e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 4.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  280 HTAIIYNVFRNNQYH-LQGHANIISCLCVSEDRRWIATAdkGPDCLVIIWDSFTGIPVHTIFDscpEGNGIMAMAMTHDA 358
Cdd:COG2319   184 GTVRLWDLATGKLLRtLTGHTGAVRSVAFSPDGKLLASG--SADGTVRLWDLATGKLLRTLTG---HSGSVRSVAFSPDG 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  359 KYLATISDAevQKVCIWKwtlaVETPACTLELPTEYGVQNYVTFNPtNNKELVSNSKTRAIyYAWyeerdTLAHSAPLLT 438
Cdd:COG2319   259 RLLASGSAD--GTVRLWD----LATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTV-RLW-----DLATGKLLRT 325

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 145279222  439 EKTFNKLVgkfsQSI-FHLNLTQILSATMEGKLVVWDIH 476
Cdd:COG2319   326 LTGHTGAV----RSVaFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 294-675 1.88e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  294 HLQGHANIISCLCVSEDRRWIATAdkGPDCLVIIWDSFTGIP-----VHTIFDSCpegngIMAMAmthDAKYLATISDAe 368
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELlrtlkGHTGPVRD-----VAASA---DGTYLASGSSD- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  369 vQKVCIWKWtlavETPACTLELpteYGVQNYVT---FNPTNnkelvsnsktraiyyawyeerdtlahsaplltektfnkl 445
Cdd:cd00200    73 -KTIRLWDL----ETGECVRTL---TGHTSYVSsvaFSPDG--------------------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  446 vgkfsqsifhlnltQILSATME-GKLVVWDIhRPPSSASTFLGFPyiKPCKLVHLQKEGitvlttidSYIVTGDIKGNIK 524
Cdd:cd00200   106 --------------RILSSSSRdKTIKVWDV-ETGKCLTTLRGHT--DWVNSVAFSPDG--------TFVASSSQDGTIK 160

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  525 FYD-HTLSIVNWYSHLKlGAIRTLSFSktpatppteksnypPDctlkgdlfvLRNFIIGTSDAAVYHLTTDGTKLEKLFV 603
Cdd:cd00200   161 LWDlRTGKCVATLTGHT-GEVNSVAFS--------------PD---------GEKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145279222  604 EPKDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSrVFEKGLGVQSLTYNPEGALLGAGFTEGTVYI 675
Cdd:cd00200   217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT-LSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
280-475 3.90e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 3.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  280 HTAIIYNVFRNNQYH-LQGHANIISCLCVSEDRRWIATAdkGPDCLVIIWDSFTGIPVHTIFDScpeGNGIMAMAMTHDA 358
Cdd:COG2319   142 GTVRLWDLATGKLLRtLTGHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGH---TGAVRSVAFSPDG 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  359 KYLATIS-DAEVQkvcIWKwtlaVETPACTLELPTEYGVQNYVTFNPtNNKELVSNSKTRAIY---YAWYEERDTLAHSA 434
Cdd:COG2319   217 KLLASGSaDGTVR---LWD----LATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRlwdLATGELLRTLTGHS 288

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 145279222  435 PLLTektfnklvgkfsqSI-FHLNLTQILSATMEGKLVVWDI 475
Cdd:COG2319   289 GGVN-------------SVaFSPDGKLLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 281-423 1.36e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  281 TAIIYNVFRNNQ-YHLQGHANIISCLCVSEDRRWIATADKgpDCLVIIWDSFTGIPVHTIfdscpEG--NGIMAMAMTHD 357
Cdd:cd00200   116 TIKVWDVETGKClTTLRGHTDWVNSVAFSPDGTFVASSSQ--DGTIKLWDLRTGKCVATL-----TGhtGEVNSVAFSPD 188

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145279222  358 -AKYLATISDAevqkvCIWKWTLAVETPACTLELPTEYGvqNYVTFNPtNNKELVSNSKTRAIYYaW 423
Cdd:cd00200   189 gEKLLSSSSDG-----TIKLWDLSTGKCLGTLRGHENGV--NSVAFSP-DGYLLASGSEDGTIRV-W 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 280-407 2.26e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 2.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  280 HTAIIYNVfRNNQ--YHLQGHANIISCLCVSEDRRWIATAdkGPDCLVIIWDSFTGIPVHTIFDScpeGNGIMAMAMTHD 357
Cdd:cd00200   157 GTIKLWDL-RTGKcvATLTGHTGEVNSVAFSPDGEKLLSS--SSDGTIKLWDLSTGKCLGTLRGH---ENGVNSVAFSPD 230

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 145279222  358 AKYLATISDAevQKVCIWKWtlavETPACTLELPteyGVQNYVT---FNPTNN 407
Cdd:cd00200   231 GYLLASGSED--GTIRVWDL----RTGECVQTLS---GHTNSVTslaWSPDGK 274
WD40 pfam00400
WD domain, G-beta repeat;
292-329 2.35e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.35e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 145279222   292 QYHLQGHANIISCLCVSEDRRWIATADKgpDCLVIIWD 329
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSD--DGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 295-329 3.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.17e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 145279222    295 LQGHANIISCLCVSEDRRWIATADKgpDCLVIIWD 329
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 274-475 2.08e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  274 LLYVCA--HTAIIYNVFRNNQYH-LQGHANIISCLCVSEDRRWIATAdkGPDCLVIIWDSFTGIPVHTIfdscpEG--NG 348
Cdd:cd00200    65 YLASGSsdKTIRLWDLETGECVRtLTGHTSYVSSVAFSPDGRILSSS--SRDKTIKVWDVETGKCLTTL-----RGhtDW 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  349 IMAMAMTHDAKYLATIS-DAEVQkvcIWKwtlaVETPACTLELPTEYGVQNYVTFNPtNNKELVSNSKTRAIyYAWyeer 427
Cdd:cd00200   138 VNSVAFSPDGTFVASSSqDGTIK---LWD----LRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTI-KLW---- 204

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 145279222  428 DtlahsapLLTEKTFNKLVGKfSQSIFHLNLTQ----ILSATMEGKLVVWDI 475
Cdd:cd00200   205 D-------LSTGKCLGTLRGH-ENGVNSVAFSPdgylLASGSEDGTIRVWDL 248
PTZ00183 PTZ00183
centrin; Provisional
 986-1089 4.56e-03

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 38.90  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145279222  986 ELPFVMRAIGFYPSEEKIDDIFNEIKfgeyvdtgKLID-KINLPDFLK---VYLNHKppfgNTMSGIHKSFEVLGyTNSK 1061
Cdd:PTZ00183   38 ELKVAMRSLGFEPKKEEIKQMIADVD--------KDGSgKIDFEEFLDimtKKLGER----DPREEILKAFRLFD-DDKT 104

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 145279222 1062 GK---KAIRRedflrllVTK--GEHMTEEE---MLD 1089
Cdd:PTZ00183  105 GKislKNLKR-------VAKelGETITDEElqeMID 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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