NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24650758|ref|NP_651599|]
View 

biorientation defective 1, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
 8-102 1.24e-16

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


:

Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 76.46  E-value: 1.24e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650758      8 LIAEVKSQGVFDEFRFNCcLADVDTKPAYQNVRTQVETAVNDFLAKQQWTPETNKVQLRERLRKHLMDSDVLDK---GVD 84
Cdd:pfam05205    2 LVHEFKKKGGFDKLRKDI-LADFDTSDAYQNLLQRLEEIVESEVERDPSLLSKNRGKAAALIEGAIDRSDVYKKaeaGVD 80

                           90       100
                   ....*....|....*....|
gi 24650758     85 QIVDQVVN--PKVATIFEPK 102
Cdd:pfam05205   81 RLIDQVLDiePKIREIRRPE 100
LGT super family cl00478
Prolipoprotein diacylglyceryl transferase;
791-927 2.53e-03

Prolipoprotein diacylglyceryl transferase;


The actual alignment was detected with superfamily member PRK13108:

Pssm-ID: 469786 [Multi-domain]  Cd Length: 460  Bit Score: 41.89  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650758   791 GPAKNSQPEDSAATMKSDAPVENANGtNGNSNGSTNGACDNVSGVVIVSDI-----LQQSTSSFVELTAGSQSHDRAESS 865
Cdd:PRK13108  294 EALEREPAELAAAAVASAASAVGPVG-PGEPNQPDDVAEAVKAEVAEVTDEvaaesVVQVADRDGESTPAVEETSEADIE 372

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24650758   866 KHEPEDIDG-KEADNQPEKTELEARQDECASQnevPTVEPQTLADSVPDLPAKESmDTLEDEK 927
Cdd:PRK13108  373 REQPGDLAGqAPAAHQVDAEAASAAPEEPAAL---ASEAHDETEPEVPEKAAPIP-DPAKPDE 431
 
Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
 8-102 1.24e-16

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 76.46  E-value: 1.24e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650758      8 LIAEVKSQGVFDEFRFNCcLADVDTKPAYQNVRTQVETAVNDFLAKQQWTPETNKVQLRERLRKHLMDSDVLDK---GVD 84
Cdd:pfam05205    2 LVHEFKKKGGFDKLRKDI-LADFDTSDAYQNLLQRLEEIVESEVERDPSLLSKNRGKAAALIEGAIDRSDVYKKaeaGVD 80

                           90       100
                   ....*....|....*....|
gi 24650758     85 QIVDQVVN--PKVATIFEPK 102
Cdd:pfam05205   81 RLIDQVLDiePKIREIRRPE 100
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 791-927 2.53e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 41.89  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650758   791 GPAKNSQPEDSAATMKSDAPVENANGtNGNSNGSTNGACDNVSGVVIVSDI-----LQQSTSSFVELTAGSQSHDRAESS 865
Cdd:PRK13108  294 EALEREPAELAAAAVASAASAVGPVG-PGEPNQPDDVAEAVKAEVAEVTDEvaaesVVQVADRDGESTPAVEETSEADIE 372

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24650758   866 KHEPEDIDG-KEADNQPEKTELEARQDECASQnevPTVEPQTLADSVPDLPAKESmDTLEDEK 927
Cdd:PRK13108  373 REQPGDLAGqAPAAHQVDAEAASAAPEEPAAL---ASEAHDETEPEVPEKAAPIP-DPAKPDE 431
 
Name Accession Description Interval E-value
COMPASS-Shg1 pfam05205
COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of ...
 8-102 1.24e-16

COMPASS (Complex proteins associated with Set1p) component shg1; The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.


Pssm-ID: 461586 [Multi-domain]  Cd Length: 100  Bit Score: 76.46  E-value: 1.24e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650758      8 LIAEVKSQGVFDEFRFNCcLADVDTKPAYQNVRTQVETAVNDFLAKQQWTPETNKVQLRERLRKHLMDSDVLDK---GVD 84
Cdd:pfam05205    2 LVHEFKKKGGFDKLRKDI-LADFDTSDAYQNLLQRLEEIVESEVERDPSLLSKNRGKAAALIEGAIDRSDVYKKaeaGVD 80

                           90       100
                   ....*....|....*....|
gi 24650758     85 QIVDQVVN--PKVATIFEPK 102
Cdd:pfam05205   81 RLIDQVLDiePKIREIRRPE 100
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 791-927 2.53e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 41.89  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650758   791 GPAKNSQPEDSAATMKSDAPVENANGtNGNSNGSTNGACDNVSGVVIVSDI-----LQQSTSSFVELTAGSQSHDRAESS 865
Cdd:PRK13108  294 EALEREPAELAAAAVASAASAVGPVG-PGEPNQPDDVAEAVKAEVAEVTDEvaaesVVQVADRDGESTPAVEETSEADIE 372

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24650758   866 KHEPEDIDG-KEADNQPEKTELEARQDECASQnevPTVEPQTLADSVPDLPAKESmDTLEDEK 927
Cdd:PRK13108  373 REQPGDLAGqAPAAHQVDAEAASAAPEEPAAL---ASEAHDETEPEVPEKAAPIP-DPAKPDE 431
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH