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Conserved domains on  [gi|24665085|ref|NP_648846|]
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lethal (3) 72Dn, isoform A [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 18616219)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-258 5.15e-19

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 5.15e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  30 IVSLAYSKSSKCLALSRATPVIELWNLEHAPYLdRVIHLPTDShVESIAWA--GNRLFSVDLSGKLIEWDVIKLKQRYEH 107
Cdd:COG2319 165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTGHTGA-VRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTL 242

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 108 SPTGNALWSIDVNPAETDIAIGSEEGHINILSIENDEITYksLFNKQKGRVLCIKFDKTGTKLVTGTE-GFVRIWNVLKG 186
Cdd:COG2319 243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDdGTVRLWDLATG 320

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24665085 187 TTLHTmtLSEKNVIVWSLQVLSD-NTIIAGDSAGFVTVWDADNATQIDSTRVLDKNVFALAVNNKEDRLVCSG 258
Cdd:COG2319 321 KLLRT--LTGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391
WD40 super family cl43672
WD40 repeat [General function prediction only];
290-567 2.34e-04

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 2.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 290 AHKHYVKSLLVIDDQIYSGGRDGILTITSSERMQAHLSQHAPFLKGSVASMAIS---KKLLLLRYPNSVHLWRLgsvapq 366
Cdd:COG2319  34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSpdgRLLASASADGTVRLWDL------ 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 367 geDKKKPWALPVGHTEEqllelppqkllqlnvkehnfIQSAAISSDANWI-CYSTLKELRISRLKSDplqveRLVDDLPE 445
Cdd:COG2319 108 --ATGLLLRTLTGHTGA--------------------VRSVAFSPDGKTLaSGSADGTVRLWDLATG-----KLLRTLTG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 446 ELQPASHIIFTKQGDLVLLNPQNNHLS-WftleeDLVTFKYTIDLSEKcKNTISHVVISSHGEYIVAASSDHIISVWKLH 524
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRlW-----DLATGKLLRTLTGH-TGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 24665085 525 GKqyKHLLNLPRHRAGTTALSMHEDYPRVVVAYANGQLVEYDL 567
Cdd:COG2319 235 TG--KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-258 5.15e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 5.15e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  30 IVSLAYSKSSKCLALSRATPVIELWNLEHAPYLdRVIHLPTDShVESIAWA--GNRLFSVDLSGKLIEWDVIKLKQRYEH 107
Cdd:COG2319 165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTGHTGA-VRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTL 242

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 108 SPTGNALWSIDVNPAETDIAIGSEEGHINILSIENDEITYksLFNKQKGRVLCIKFDKTGTKLVTGTE-GFVRIWNVLKG 186
Cdd:COG2319 243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDdGTVRLWDLATG 320

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24665085 187 TTLHTmtLSEKNVIVWSLQVLSD-NTIIAGDSAGFVTVWDADNATQIDSTRVLDKNVFALAVNNKEDRLVCSG 258
Cdd:COG2319 321 KLLRT--LTGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-268 2.73e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 2.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  20 VRFYTIKPREIVSLAYSKSSKCLALSRATPVIELWNLEhAPYLDRVI--HlptDSHVESIAWAGNR--LFSVDLSGKLIE 95
Cdd:cd00200  44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TGECVRTLtgH---TSYVSSVAFSPDGriLSSSSRDKTIKV 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  96 WDVIKLKQRYEHSPTGNALWSIDVNPAETDIAIGSEEGHINILSIENDEITYksLFNKQKGRVLCIKFDKTGTKLVTGTE 175
Cdd:cd00200 120 WDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGHTGEVNSVAFSPDGEKLLSSSS 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 176 -GFVRIWNVLKGTTLHtmTLSEKNVIVWSLQVLSDNTIIA-GDSAGFVTVWDADNATQIDSTRVLDKNVFALAVNNKEDR 253
Cdd:cd00200 198 dGTIKLWDLSTGKCLG--TLRGHENGVNSVAFSPDGYLLAsGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275

                       250
                ....*....|....*
gi 24665085 254 LvCSGMQPPLIRIFS 268
Cdd:cd00200 276 L-ASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 30-225 4.85e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 4.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085   30 IVSLAYSKSSKCLALSRATPVIELWNLEHAPYLDRVIHLP-----TDSHVESIAWAG---NRLFSVDLSGKLIEWDVIKL 101
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPvvelaSRSKLSGICWNSyikSQVASSNFEGVVQVWDVARS 565

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  102 KQRYEHSPTGNALWSIDVNPAE-TDIAIGSEEGHINILSIeNDEITYKSLfnKQKGRVLCIKF-DKTGTKLVTGTEGFVR 179
Cdd:PLN00181 566 QLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSI-NQGVSIGTI--KTKANICCVQFpSESGRSLAFGSADHKV 642

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 24665085  180 IWNVLKGTTLHTMTLSEKNVIVWSLQVLSDNTIIAGDSAGFVTVWD 225
Cdd:PLN00181 643 YYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWD 688
WD40 COG2319
WD40 repeat [General function prediction only];
290-567 2.34e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 2.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 290 AHKHYVKSLLVIDDQIYSGGRDGILTITSSERMQAHLSQHAPFLKGSVASMAIS---KKLLLLRYPNSVHLWRLgsvapq 366
Cdd:COG2319  34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSpdgRLLASASADGTVRLWDL------ 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 367 geDKKKPWALPVGHTEEqllelppqkllqlnvkehnfIQSAAISSDANWI-CYSTLKELRISRLKSDplqveRLVDDLPE 445
Cdd:COG2319 108 --ATGLLLRTLTGHTGA--------------------VRSVAFSPDGKTLaSGSADGTVRLWDLATG-----KLLRTLTG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 446 ELQPASHIIFTKQGDLVLLNPQNNHLS-WftleeDLVTFKYTIDLSEKcKNTISHVVISSHGEYIVAASSDHIISVWKLH 524
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRlW-----DLATGKLLRTLTGH-TGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 24665085 525 GKqyKHLLNLPRHRAGTTALSMHEDYPRVVVAYANGQLVEYDL 567
Cdd:COG2319 235 TG--KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 494-603 5.62e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 5.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 494 KNTISHVVISSHGEYIVAASSDHIISVWKLhgKQYKHLLNLPRHRAGTTALSMHEDYPRVVVAYANGQLVEYDLvnRIFT 573
Cdd:cd00200  93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL--RTGK 168

                        90       100       110
                ....*....|....*....|....*....|
gi 24665085 574 CETNeyLIPETRrhCINGISLDPQNRNIFI 603
Cdd:cd00200 169 CVAT--LTGHTG--EVNSVAFSPDGEKLLS 194
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-258 5.15e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 5.15e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  30 IVSLAYSKSSKCLALSRATPVIELWNLEHAPYLdRVIHLPTDShVESIAWA--GNRLFSVDLSGKLIEWDVIKLKQRYEH 107
Cdd:COG2319 165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTGHTGA-VRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTL 242

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 108 SPTGNALWSIDVNPAETDIAIGSEEGHINILSIENDEITYksLFNKQKGRVLCIKFDKTGTKLVTGTE-GFVRIWNVLKG 186
Cdd:COG2319 243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDdGTVRLWDLATG 320

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24665085 187 TTLHTmtLSEKNVIVWSLQVLSD-NTIIAGDSAGFVTVWDADNATQIDSTRVLDKNVFALAVNNKEDRLVCSG 258
Cdd:COG2319 321 KLLRT--LTGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391
WD40 COG2319
WD40 repeat [General function prediction only];
27-416 2.93e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 2.93e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  27 PREIVSLAYSKSSKCLALSRATPVIELWNLEHAPYLDRVIHLPTDSHVESIAWAGNRLFSVDLSGKLIEWDVIKLKQRYE 106
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 107 HSPTGNALWSIDVNPAETDIAIGSEEGHINILSIENDEITYKslFNKQKGRVLCIKFDKTGTKLVTGTE-GFVRIWNVLK 185
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT--LTGHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLAT 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 186 GTTLHtmTLSEKNVIVWSLQVLSDNTIIA-GDSAGFVTVWDADNATQIDSTRVLDKNVFALAVNNKEDRLVcSGMQPPLI 264
Cdd:COG2319 194 GKLLR--TLTGHTGAVRSVAFSPDGKLLAsGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTV 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 265 RIFSktkikreeSTSERWIKFLqrDAHKHYVKSLLVIDD--QIYSGGRDGILTI--TSSERMQAHLSQHApflkGSVASM 340
Cdd:COG2319 271 RLWD--------LATGELLRTL--TGHSGGVNSVAFSPDgkLLASGSDDGTVRLwdLATGKLLRTLTGHT----GAVRSV 336

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24665085 341 AIS---KKLLLLRYPNSVHLWRLgsvapqgeDKKKPWALPVGHTeeqllelppqkllqlnvkehNFIQSAAISSDANWI 416
Cdd:COG2319 337 AFSpdgKTLASGSDDGTVRLWDL--------ATGELLRTLTGHT--------------------GAVTSVAFSPDGRTL 387
WD40 COG2319
WD40 repeat [General function prediction only];
20-316 5.18e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 5.18e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  20 VRFYTIKPREIVSLAYSKSSKCLALSRATPVIELWNLEHAPYLdRVIHLPTDShVESIAWA--GNRLFSVDLSGKLIEWD 97
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGA-VTSVAFSpdGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  98 VIKLKQRYEHSPTGNALWSIDVNPAETDIAIGSEEGHINILSIENDEITYksLFNKQKGRVLCIKFDKTGTKLVTGTE-G 176
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR--TLTGHSGSVRSVAFSPDGRLLASGSAdG 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 177 FVRIWNVLKGTTLHtmTLSEKNVIVWSLQVLSDNTIIA-GDSAGFVTVWDADNATQIDSTRVLDKNVFALAVNNKEDRLV 255
Cdd:COG2319 269 TVRLWDLATGELLR--TLTGHSGGVNSVAFSPDGKLLAsGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLA 346

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24665085 256 CSGmqpplirifSKTKIKREESTSERWIKFLQrdAHKHYVKSLLVIDD--QIYSGGRDGILTI 316
Cdd:COG2319 347 SGS---------DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDgrTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
20-228 3.77e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 3.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  20 VRFYTIKPREIVSLAYSKSSKCLALSRATPVIELWNLEHAPYLdRVIHLPTDShVESIAWA--GNRLFSVDLSGKLIEWD 97
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL-RTLTGHSGS-VRSVAFSpdGRLLASGSADGTVRLWD 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  98 VIKLKQRYEHSPTGNALWSIDVNPAETDIAIGSEEGHINILSIENDEITYKslFNKQKGRVLCIKFDKTGTKLVTGTE-G 176
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT--LTGHTGAVRSVAFSPDGKTLASGSDdG 352

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 24665085 177 FVRIWNVLKGTTLHtmTLSEKNVIVWSLQVLSDNTIIA-GDSAGFVTVWDADN 228
Cdd:COG2319 353 TVRLWDLATGELLR--TLTGHTGAVTSVAFSPDGRTLAsGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
42-562 2.53e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 2.53e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  42 LALSRATPVIELWNLEHAPYLDRVIHLPTDSHVESIAWAGNRLFSVDLSGKLIEWDVIKLKQRYEHSPTGNALWSIDVNP 121
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 122 AETDIAIGSEEGHINILSIENDEITykSLFNKQKGRVLCIKFDKTGTKLVTGTE-GFVRIWNVLKGTTLHTmtLSEKNVI 200
Cdd:COG2319  89 DGRLLASASADGTVRLWDLATGLLL--RTLTGHTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRT--LTGHSGA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 201 VWSLQVLSDNTIIA-GDSAGFVTVWDADNATQIDSTRVLDKNVFALAVNNKEDRLVcSGMQPPLIRIFSktkikreeSTS 279
Cdd:COG2319 165 VTSVAFSPDGKLLAsGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWD--------LAT 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 280 ERWIKFLQrdAHKHYVKSLLVIDD--QIYSGGRDGiltitssermqahlsqhapflkgsvasmaiskkllllrypnSVHL 357
Cdd:COG2319 236 GKLLRTLT--GHSGSVRSVAFSPDgrLLASGSADG-----------------------------------------TVRL 272

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 358 WRLGSvapqgedkKKPWALPVGHTeeqllelppqkllqlnvkehNFIQSAAISSDANWICYSTlkelrisrlksdplqve 437
Cdd:COG2319 273 WDLAT--------GELLRTLTGHS--------------------GGVNSVAFSPDGKLLASGS----------------- 307

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 438 rlvDDlpeelqpashiiftkqGDLVLLNPQNNHLswftleedLVTFKYTIDlsekcknTISHVVISSHGEYIVAASSDHI 517
Cdd:COG2319 308 ---DD----------------GTVRLWDLATGKL--------LRTLTGHTG-------AVRSVAFSPDGKTLASGSDDGT 353

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*
gi 24665085 518 ISVWKLHGKQykHLLNLPRHRAGTTALSMHEDYPRVVVAYANGQL 562
Cdd:COG2319 354 VRLWDLATGE--LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-268 2.73e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 2.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  20 VRFYTIKPREIVSLAYSKSSKCLALSRATPVIELWNLEhAPYLDRVI--HlptDSHVESIAWAGNR--LFSVDLSGKLIE 95
Cdd:cd00200  44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TGECVRTLtgH---TSYVSSVAFSPDGriLSSSSRDKTIKV 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  96 WDVIKLKQRYEHSPTGNALWSIDVNPAETDIAIGSEEGHINILSIENDEITYksLFNKQKGRVLCIKFDKTGTKLVTGTE 175
Cdd:cd00200 120 WDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGHTGEVNSVAFSPDGEKLLSSSS 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 176 -GFVRIWNVLKGTTLHtmTLSEKNVIVWSLQVLSDNTIIA-GDSAGFVTVWDADNATQIDSTRVLDKNVFALAVNNKEDR 253
Cdd:cd00200 198 dGTIKLWDLSTGKCLG--TLRGHENGVNSVAFSPDGYLLAsGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275

                       250
                ....*....|....*
gi 24665085 254 LvCSGMQPPLIRIFS 268
Cdd:cd00200 276 L-ASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-349 3.06e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 3.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 155 KGRVLCIKFDKTGTKLVTGTE-GFVRIWNVLKGTTLHTMTLSEKNViVWSLQVLSDNTIIAGDSAGFVTVWDADNATQID 233
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPV-RDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 234 STRVLDKNVFALAVNNKeDRLVCSGMQPPLIRIFsktkikreESTSERWIKFLQrdAHKHYVKSLLVIDDQ--IYSGGRD 311
Cdd:cd00200  88 TLTGHTSYVSSVAFSPD-GRILSSSSRDKTIKVW--------DVETGKCLTTLR--GHTDWVNSVAFSPDGtfVASSSQD 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 24665085 312 GILTI--TSSERMQAHLSQHapflKGSVASMAISKKLLLL 349
Cdd:cd00200 157 GTIKLwdLRTGKCVATLTGH----TGEVNSVAFSPDGEKL 192
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 30-225 4.85e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 4.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085   30 IVSLAYSKSSKCLALSRATPVIELWNLEHAPYLDRVIHLP-----TDSHVESIAWAG---NRLFSVDLSGKLIEWDVIKL 101
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPvvelaSRSKLSGICWNSyikSQVASSNFEGVVQVWDVARS 565

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085  102 KQRYEHSPTGNALWSIDVNPAE-TDIAIGSEEGHINILSIeNDEITYKSLfnKQKGRVLCIKF-DKTGTKLVTGTEGFVR 179
Cdd:PLN00181 566 QLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSI-NQGVSIGTI--KTKANICCVQFpSESGRSLAFGSADHKV 642

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 24665085  180 IWNVLKGTTLHTMTLSEKNVIVWSLQVLSDNTIIAGDSAGFVTVWD 225
Cdd:PLN00181 643 YYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWD 688
WD40 COG2319
WD40 repeat [General function prediction only];
290-567 2.34e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 2.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 290 AHKHYVKSLLVIDDQIYSGGRDGILTITSSERMQAHLSQHAPFLKGSVASMAIS---KKLLLLRYPNSVHLWRLgsvapq 366
Cdd:COG2319  34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSpdgRLLASASADGTVRLWDL------ 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 367 geDKKKPWALPVGHTEEqllelppqkllqlnvkehnfIQSAAISSDANWI-CYSTLKELRISRLKSDplqveRLVDDLPE 445
Cdd:COG2319 108 --ATGLLLRTLTGHTGA--------------------VRSVAFSPDGKTLaSGSADGTVRLWDLATG-----KLLRTLTG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 446 ELQPASHIIFTKQGDLVLLNPQNNHLS-WftleeDLVTFKYTIDLSEKcKNTISHVVISSHGEYIVAASSDHIISVWKLH 524
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRlW-----DLATGKLLRTLTGH-TGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 24665085 525 GKqyKHLLNLPRHRAGTTALSMHEDYPRVVVAYANGQLVEYDL 567
Cdd:COG2319 235 TG--KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
163-567 2.88e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 2.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 163 FDKTGTKLVTGTEGFVRIWNVLKGTTLHTMTLSEKNVIVWSLQVLSDNTIIAGDSAGFVTVWDADNATQIDSTRVLDKNV 242
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 243 FALAVNNKEDRLVcSGMQPPLIRIFSktkikreeSTSERWIKFLQrdAHKHYVKSLLVIDD--QIYSGGRDGILTI--TS 318
Cdd:COG2319  82 LSVAFSPDGRLLA-SASADGTVRLWD--------LATGLLLRTLT--GHTGAVRSVAFSPDgkTLASGSADGTVRLwdLA 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 319 SERMQAHLSQHApflkGSVASMAIS---KKLLLLRYPNSVHLWRLgsvapqgEDKKKPWALPvGHTeeqllelppqkllq 395
Cdd:COG2319 151 TGKLLRTLTGHS----GAVTSVAFSpdgKLLASGSDDGTVRLWDL-------ATGKLLRTLT-GHT-------------- 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 396 lnvkehNFIQSAAISSDANWI-CYSTLKELRISRLKSdplqverlvddlPEELQPASHiiftkqgdlvllnpqnnHLSWf 474
Cdd:COG2319 205 ------GAVRSVAFSPDGKLLaSGSADGTVRLWDLAT------------GKLLRTLTG-----------------HSGS- 248

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 475 tleedlvtfkytidlsekckntISHVVISSHGEYIVAASSDHIISVWKLHGKQYKHLlnLPRHRAGTTALSMHEDYPRVV 554
Cdd:COG2319 249 ----------------------VRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPDGKLLA 304

                       410
                ....*....|...
gi 24665085 555 VAYANGQLVEYDL 567
Cdd:COG2319 305 SGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 494-603 5.62e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 5.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24665085 494 KNTISHVVISSHGEYIVAASSDHIISVWKLhgKQYKHLLNLPRHRAGTTALSMHEDYPRVVVAYANGQLVEYDLvnRIFT 573
Cdd:cd00200  93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL--RTGK 168

                        90       100       110
                ....*....|....*....|....*....|
gi 24665085 574 CETNeyLIPETRrhCINGISLDPQNRNIFI 603
Cdd:cd00200 169 CVAT--LTGHTG--EVNSVAFSPDGEKLLS 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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