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Conserved domains on  [gi|24663552|ref|NP_648610|]
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uncharacterized protein Dmel_CG14120 [Drosophila melanogaster]

Protein Classification

DNA/RNA non-specific endonuclease( domain architecture ID 10054573)

DNA/RNA non-specific endonuclease catalyzes the cleavage of dsRNA, ssRNA, ssDNA, dsDNA, as well as RNA/DNA hybrids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NUC cd00091
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 164-416 4.08e-70

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.


:

Pssm-ID: 238043  Cd Length: 241  Bit Score: 234.96  E-value: 4.08e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  164 LQSYELCHDAEAEATRYVHHVLYPSSYDYQHGVARPNFLELDFygGRDVNTKYTQVQQNITISNILGLDASPYFNFSDdr 243
Cdd:cd00091    1 LQYGRPGVLADTEVLSYTHYVLSYNRATRLPLWVAEHIDKEDL--GKNVDRKYDQFKQDPRIPPLFSATNSDYKGSGS-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  244 iLSRGHMIAKTDQIF-GAAQHTTFLFINVAPQWQTFNGGNWEKVETSVRKFVADRNLTTDCYTGTWGVSTLPDVDGIere 322
Cdd:cd00091   77 -LDRGHLAPAADPVWsQDAQDATFYLTNMAPQVQGFNQGNWAYLEDYLRDLAASEGKDVYVVTGPLFLPDLDGDGGS--- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  323 lYLDFDENNNGLIPVPKIYFRVVIDRV----TREGIVLIGINNPYLTLEQiqkdyILCQDIGHQLSWLTWYKEdlhEGYS 398
Cdd:cd00091  153 -YLSTQVINNGKVAVPTHFWKVIIDEKapgnLSVGAFVLPNNNPHDTLEF-----ILCVEKTFQVPVASVEKA---TGLS 223

                        250
                 ....*....|....*...
gi 24663552  399 YACSVEDFIEVVKDLPLE 416
Cdd:cd00091  224 FFCNVPDSVSAVLELKKK 241
NUC cd00091
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 1111-1359 9.67e-70

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.


:

Pssm-ID: 238043  Cd Length: 241  Bit Score: 234.19  E-value: 9.67e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552 1111 TYDVCHDELSEVTRYVHHVLYPGSDQYQRSVSRPSFIPGDFygGKDVNTLYTQVQQNITVSEILGMDASPYFNTTGnvyL 1190
Cdd:cd00091    3 YGRPGVLADTEVLSYTHYVLSYNRATRLPLWVAEHIDKEDL--GKNVDRKYDQFKQDPRIPPLFSATNSDYKGSGS---L 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552 1191 ARGHLSAKTDFVF-GAAQKASFFFVNAAPQWQTFNGGNWERIEDSVRKFVADENITVDCYTGTWGVSTLPDVNGIgrelY 1269
Cdd:cd00091   78 DRGHLAPAADPVWsQDAQDATFYLTNMAPQVQGFNQGNWAYLEDYLRDLAASEGKDVYVVTGPLFLPDLDGDGGS----Y 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552 1270 LDFDENNNGLIPVPKLYFRVIIDR----ESRNGIVLLGVNNPHATieqieEEYIICQDIGAQLSWVSWTKedlKKGYSYA 1345
Cdd:cd00091  154 LSTQVINNGKVAVPTHFWKVIIDEkapgNLSVGAFVLPNNNPHDT-----LEFILCVEKTFQVPVASVEK---ATGLSFF 225

                        250
                 ....*....|....
gi 24663552 1346 CTVEDFTAVVKDLP 1359
Cdd:cd00091  226 CNVPDSVSAVLELK 239
NUC super family cl00089
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 718-967 1.06e-33

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.


The actual alignment was detected with superfamily member cd00091:

Pssm-ID: 469610  Cd Length: 241  Bit Score: 130.57  E-value: 1.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  718 LSHVELCYDQQEQISRYARYELTPANVAYQKGVAQPGYLRGDFysGEDVNVLYDQSHQLDAFSTALGLDASQYFDSTKdl 797
Cdd:cd00091    1 LQYGRPGVLADTEVLSYTHYVLSYNRATRLPLWVAEHIDKEDL--GKNVDRKYDQFKQDPRIPPLFSATNSDYKGSGS-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  798 yLTRGQLAARLDFV-HSSAQRATHFYVNAVPQWRSINIGNWLAVESSLKQFVADEALNVSVHAGSYDISTLPNSQGVQTP 876
Cdd:cd00091   77 -LDRGHLAPAADPVwSQDAQDATFYLTNMAPQVQGFNQGNWAYLEDYLRDLAASEGKDVYVVTGPLFLPDLDGDGGSYLS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  877 LYLNAETKqLPVAKILYRIVID----QESRKGVVLIVVNNPHITLTETLedyviCEDVGAQIDWLDWDKANlqkGYSYAC 952
Cdd:cd00091  156 TQVINNGK-VAVPTHFWKVIIDekapGNLSVGAFVLPNNNPHDTLEFIL-----CVEKTFQVPVASVEKAT---GLSFFC 226

                        250
                 ....*....|....*
gi 24663552  953 SVEDFIEVVKDLPTD 967
Cdd:cd00091  227 NVPDSVSAVLELKKK 241
 
Name Accession Description Interval E-value
NUC cd00091
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 164-416 4.08e-70

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.


Pssm-ID: 238043  Cd Length: 241  Bit Score: 234.96  E-value: 4.08e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  164 LQSYELCHDAEAEATRYVHHVLYPSSYDYQHGVARPNFLELDFygGRDVNTKYTQVQQNITISNILGLDASPYFNFSDdr 243
Cdd:cd00091    1 LQYGRPGVLADTEVLSYTHYVLSYNRATRLPLWVAEHIDKEDL--GKNVDRKYDQFKQDPRIPPLFSATNSDYKGSGS-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  244 iLSRGHMIAKTDQIF-GAAQHTTFLFINVAPQWQTFNGGNWEKVETSVRKFVADRNLTTDCYTGTWGVSTLPDVDGIere 322
Cdd:cd00091   77 -LDRGHLAPAADPVWsQDAQDATFYLTNMAPQVQGFNQGNWAYLEDYLRDLAASEGKDVYVVTGPLFLPDLDGDGGS--- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  323 lYLDFDENNNGLIPVPKIYFRVVIDRV----TREGIVLIGINNPYLTLEQiqkdyILCQDIGHQLSWLTWYKEdlhEGYS 398
Cdd:cd00091  153 -YLSTQVINNGKVAVPTHFWKVIIDEKapgnLSVGAFVLPNNNPHDTLEF-----ILCVEKTFQVPVASVEKA---TGLS 223

                        250
                 ....*....|....*...
gi 24663552  399 YACSVEDFIEVVKDLPLE 416
Cdd:cd00091  224 FFCNVPDSVSAVLELKKK 241
NUC cd00091
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 1111-1359 9.67e-70

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.


Pssm-ID: 238043  Cd Length: 241  Bit Score: 234.19  E-value: 9.67e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552 1111 TYDVCHDELSEVTRYVHHVLYPGSDQYQRSVSRPSFIPGDFygGKDVNTLYTQVQQNITVSEILGMDASPYFNTTGnvyL 1190
Cdd:cd00091    3 YGRPGVLADTEVLSYTHYVLSYNRATRLPLWVAEHIDKEDL--GKNVDRKYDQFKQDPRIPPLFSATNSDYKGSGS---L 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552 1191 ARGHLSAKTDFVF-GAAQKASFFFVNAAPQWQTFNGGNWERIEDSVRKFVADENITVDCYTGTWGVSTLPDVNGIgrelY 1269
Cdd:cd00091   78 DRGHLAPAADPVWsQDAQDATFYLTNMAPQVQGFNQGNWAYLEDYLRDLAASEGKDVYVVTGPLFLPDLDGDGGS----Y 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552 1270 LDFDENNNGLIPVPKLYFRVIIDR----ESRNGIVLLGVNNPHATieqieEEYIICQDIGAQLSWVSWTKedlKKGYSYA 1345
Cdd:cd00091  154 LSTQVINNGKVAVPTHFWKVIIDEkapgNLSVGAFVLPNNNPHDT-----LEFILCVEKTFQVPVASVEK---ATGLSFF 225

                        250
                 ....*....|....
gi 24663552 1346 CTVEDFTAVVKDLP 1359
Cdd:cd00091  226 CNVPDSVSAVLELK 239
Endonuclease_NS pfam01223
DNA/RNA non-specific endonuclease;
1089-1351 2.19e-48

DNA/RNA non-specific endonuclease;


Pssm-ID: 460120  Cd Length: 220  Bit Score: 171.85  E-value: 2.19e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552   1089 GGTDLLEVGFQLSSSSSDDFLQTYDVCHDELSEVTRYVHHVLYPGSDQYQRSVSRPSFIPGDFYGGKDVNTLYTQVQQNi 1168
Cdd:pfam01223    1 NSGTLFKVGFPGSGSDVVLFYKYYSLCYDRRTRRALWVAHHLTGASLAGSKGRRRPGFKQDPRIPGAYFRTLYTDYTGS- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552   1169 tvseilGMDaspyfnttgnvylaRGHLSAKTDFVFGA-AQKASFFFVNAAPQWQTFNGGNWERIEDSVRKFVADENITVD 1247
Cdd:pfam01223   80 ------GFD--------------RGHLAPAADFKFSAgANAATFNFTNIAPQWAGFNQGNWAYLENYVRDLAARHNNSVY 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552   1248 CYTGTWGVSTLPDVNGigrelyldfdennnglIPVPKLYFRVIIDRESRNGivlLGVNNPHATIEQieeeyiicQDIGAQ 1327
Cdd:pfam01223  140 VYTGPLYVPNLLDKNK----------------VAVPTHFWKVILSEDGDGG---GGLNAPAFVLPN--------KYILDD 192

                          250       260
                   ....*....|....*....|....*....
gi 24663552   1328 LSWVSW-----TKEDLkKGYSYACTVEDF 1351
Cdd:pfam01223  193 GPLRTFqvpvdELERL-TGLDFCCGVPDA 220
Endonuclease_NS smart00892
DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share ...
 1112-1350 1.01e-40

DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. An histidine has been shown to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.


Pssm-ID: 214889 [Multi-domain]  Cd Length: 198  Bit Score: 149.10  E-value: 1.01e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    1112 YDVCHDELSEVTRYVHHVLYPGSDQY-QRSVSRPSFIPGDfyggkdvntlytqvqqnITVSEILGMDASPYFNTtgnvYL 1190
Cdd:smart00892    4 YALCYDERRRLPLWVAYHLTGSTRQGkNTGRKRPWFKPDG-----------------WHLPAIFQAVNSDYTGS----GY 62

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    1191 ARGHLSAKTD-FVFGAAQKASFFFVNAAPQWQTFNGGNWERIEDSVRKFVADENITVDCYTGTWGVSTLPDVNgigrely 1269
Cdd:smart00892   63 DRGHLAPAADhGVSQEAMAATFYLTNIVPQTAGFNQGNWNRLENYVRKLLAKNKDTVYVVTGPIYLPTLPDNN------- 135

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    1270 ldfdennnglIPVPKLYFRVIID-RESRNGIVLLGVNNPHATIEQIEEEyiicQDIGAQLSWVSWtkedlKKGYSYACTV 1348
Cdd:smart00892  136 ----------VAVPSHFWKVILSeDGSNGGLAAIAFNLPNAPINEDYPL----CEFQVPVDNIER-----LTGLDFFCGL 196


                    ..
gi 24663552    1349 ED 1350
Cdd:smart00892  197 PD 198
Endonuclease_NS pfam01223
DNA/RNA non-specific endonuclease;
147-406 9.90e-39

DNA/RNA non-specific endonuclease;


Pssm-ID: 460120  Cd Length: 220  Bit Score: 144.12  E-value: 9.90e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    147 GGTDLVQVGFEVEDGG---FLQSYELCHDAEAEATRYVHHVLYPSSYDYQHGVARPNFLELDFYGGRDVNTKYTQVQQNi 223
Cdd:pfam01223    1 NSGTLFKVGFPGSGSDvvlFYKYYSLCYDRRTRRALWVAHHLTGASLAGSKGRRRPGFKQDPRIPGAYFRTLYTDYTGS- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    224 tisnilGLDaspyfnfsddrilsRGHMIAKTDQIFGA-AQHTTFLFINVAPQWQTFNGGNWEKVETSVRKFVADRNLTTD 302
Cdd:pfam01223   80 ------GFD--------------RGHLAPAADFKFSAgANAATFNFTNIAPQWAGFNQGNWAYLENYVRDLAARHNNSVY 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    303 CYTGTWGVSTLPDvdgierelyldfdennNGLIPVPKIYFRVVIDRVTREGivlIGINNPYLTLEQiqkdyilcQDIGHQ 382
Cdd:pfam01223  140 VYTGPLYVPNLLD----------------KNKVAVPTHFWKVILSEDGDGG---GGLNAPAFVLPN--------KYILDD 192

                          250       260
                   ....*....|....*....|....*....
gi 24663552    383 LSWLTWY-----KEDLHeGYSYACSVEDF 406
Cdd:pfam01223  193 GPLRTFQvpvdeLERLT-GLDFCCGVPDA 220
Endonuclease_NS smart00892
DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share ...
 167-405 1.70e-36

DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. An histidine has been shown to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.


Pssm-ID: 214889 [Multi-domain]  Cd Length: 198  Bit Score: 137.15  E-value: 1.70e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     167 YELCHDAEAEATRYVHHVLYPSS-YDYQHGVARPNFLELDfyggrdvntkytqvqqnITISNILGLDASPYFNfsddRIL 245
Cdd:smart00892    4 YALCYDERRRLPLWVAYHLTGSTrQGKNTGRKRPWFKPDG-----------------WHLPAIFQAVNSDYTG----SGY 62

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     246 SRGHMIAKTD-QIFGAAQHTTFLFINVAPQWQTFNGGNWEKVETSVRKFVADRNLTTDCYTGTWGVSTLPDVDgierely 324
Cdd:smart00892   63 DRGHLAPAADhGVSQEAMAATFYLTNIVPQTAGFNQGNWNRLENYVRKLLAKNKDTVYVVTGPIYLPTLPDNN------- 135

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     325 ldfdennnglIPVPKIYFRVVID-RVTREGIVLIGINNPYLTleqIQKDYILCqDIGHQLSWLTWYKedlheGYSYACSV 403
Cdd:smart00892  136 ----------VAVPSHFWKVILSeDGSNGGLAAIAFNLPNAP---INEDYPLC-EFQVPVDNIERLT-----GLDFFCGL 196


                    ..
gi 24663552     404 ED 405
Cdd:smart00892  197 PD 198
NUC cd00091
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 718-967 1.06e-33

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.


Pssm-ID: 238043  Cd Length: 241  Bit Score: 130.57  E-value: 1.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  718 LSHVELCYDQQEQISRYARYELTPANVAYQKGVAQPGYLRGDFysGEDVNVLYDQSHQLDAFSTALGLDASQYFDSTKdl 797
Cdd:cd00091    1 LQYGRPGVLADTEVLSYTHYVLSYNRATRLPLWVAEHIDKEDL--GKNVDRKYDQFKQDPRIPPLFSATNSDYKGSGS-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  798 yLTRGQLAARLDFV-HSSAQRATHFYVNAVPQWRSINIGNWLAVESSLKQFVADEALNVSVHAGSYDISTLPNSQGVQTP 876
Cdd:cd00091   77 -LDRGHLAPAADPVwSQDAQDATFYLTNMAPQVQGFNQGNWAYLEDYLRDLAASEGKDVYVVTGPLFLPDLDGDGGSYLS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  877 LYLNAETKqLPVAKILYRIVID----QESRKGVVLIVVNNPHITLTETLedyviCEDVGAQIDWLDWDKANlqkGYSYAC 952
Cdd:cd00091  156 TQVINNGK-VAVPTHFWKVIIDekapGNLSVGAFVLPNNNPHDTLEFIL-----CVEKTFQVPVASVEKAT---GLSFFC 226

                        250
                 ....*....|....*
gi 24663552  953 SVEDFIEVVKDLPTD 967
Cdd:cd00091  227 NVPDSVSAVLELKKK 241
Endonuclease_NS smart00892
DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share ...
 720-956 4.28e-29

DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. An histidine has been shown to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.


Pssm-ID: 214889 [Multi-domain]  Cd Length: 198  Bit Score: 115.58  E-value: 4.28e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     720 HVELCYDQQEQISRYARYELTPANVAY-QKGVAQPgylrgDFYSGEDVNVLYDQShqldafstalglDASQYFDStkdlY 798
Cdd:smart00892    3 HYALCYDERRRLPLWVAYHLTGSTRQGkNTGRKRP-----WFKPDGWHLPAIFQA------------VNSDYTGS----G 61

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     799 LTRGQLAAR-LDFVHSSAQRATHFYVNAVPQWRSINIGNWLAVESSLKQFVADEALNVSVHAGSYDISTLPNsqgvqtpl 877
Cdd:smart00892   62 YDRGHLAPAaDHGVSQEAMAATFYLTNIVPQTAGFNQGNWNRLENYVRKLLAKNKDTVYVVTGPIYLPTLPD-------- 133

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     878 ylnaetKQLPVAKILYRIVID-QESRKGVVLIVVNNPHITlteTLEDYVICEdVGAQIDWLDWdkanlQKGYSYACSVED 956
Cdd:smart00892  134 ------NNVAVPSHFWKVILSeDGSNGGLAAIAFNLPNAP---INEDYPLCE-FQVPVDNIER-----LTGLDFFCGLPD 198
Endonuclease_NS pfam01223
DNA/RNA non-specific endonuclease;
702-957 3.42e-27

DNA/RNA non-specific endonuclease;


Pssm-ID: 460120  Cd Length: 220  Bit Score: 110.99  E-value: 3.42e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    702 GGTDVVHIGFDVAAG----FLSHVELCYDQQEQISRYARYELTPANVAYQKGVAQPGYLRGDFYSGEDVNVLYDQShqld 777
Cdd:pfam01223    1 NSGTLFKVGFPGSGSdvvlFYKYYSLCYDRRTRRALWVAHHLTGASLAGSKGRRRPGFKQDPRIPGAYFRTLYTDY---- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    778 afsTALGLDasqyfdstkdlyltRGQLAARLDFVHSS-AQRATHFYVNAVPQWRSINIGNWLAVESSLKQFVADEALNVS 856
Cdd:pfam01223   77 ---TGSGFD--------------RGHLAPAADFKFSAgANAATFNFTNIAPQWAGFNQGNWAYLENYVRDLAARHNNSVY 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    857 VHAGSYDISTLPNSQGVQTPLYlnaetkqlpvakiLYRIVIDQESRKGVvliVVNNPHITLTEtledyvicEDVGAQIDW 936
Cdd:pfam01223  140 VYTGPLYVPNLLDKNKVAVPTH-------------FWKVILSEDGDGGG---GLNAPAFVLPN--------KYILDDGPL 195

                          250       260
                   ....*....|....*....|....*
gi 24663552    937 LDW----DKANLQKGYSYACSVEDF 957
Cdd:pfam01223  196 RTFqvpvDELERLTGLDFCCGVPDA 220
NUC1 COG1864
DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism];
1192-1298 1.60e-11

DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism];


Pssm-ID: 441469  Cd Length: 238  Bit Score: 65.70  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552 1192 RGHLSAKTDFVFG-AAQKASFFFVNAAPQWQTFNGGNWERIEDSVRKFV-ADENITVdcYTGtwGVSTLPDVNGIGrely 1269
Cdd:COG1864   90 RGHLAPSADRTFSkEANSETFLMTNISPQAPDFNQGIWARLENYVRDLArKGGEVYV--VTG--PVFDDGDLKTIG---- 161

                         90       100
                 ....*....|....*....|....*....
gi 24663552 1270 ldfdennNGLIPVPKLYFRVIIDRESRNG 1298
Cdd:COG1864  162 -------SGGVAVPTAFWKVVVDPDKNTG 183
NUC1 COG1864
DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism];
172-347 2.01e-07

DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism];


Pssm-ID: 441469  Cd Length: 238  Bit Score: 53.76  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  172 DAEAEATRYVHHVLYPSSYDYQHGVarPNFleldfyggrdvntkytqVQQNITISNILG-LDASPYFnFSDDRI------ 244
Cdd:COG1864   19 RALSTNNYLLCYTGYSLSYNESRRT--PNW-----------------VAYNLDGSWLGKsLKRSDDF-RPDPRLpsgyra 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  245 ---------LSRGHMIAKTDQIFG-AAQHTTFLFINVAPQWQTFNGGNWEKVETSVRKFVADRNlttDCY--TGtwGVST 312
Cdd:COG1864   79 tladytgsgYDRGHLAPSADRTFSkEANSETFLMTNISPQAPDFNQGIWARLENYVRDLARKGG---EVYvvTG--PVFD 153

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 24663552  313 LPDVDGIerelyldfdenNNGLIPVPKIYFRVVID 347
Cdd:COG1864  154 DGDLKTI-----------GSGGVAVPTAFWKVVVD 177
 
Name Accession Description Interval E-value
NUC cd00091
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 164-416 4.08e-70

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.


Pssm-ID: 238043  Cd Length: 241  Bit Score: 234.96  E-value: 4.08e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  164 LQSYELCHDAEAEATRYVHHVLYPSSYDYQHGVARPNFLELDFygGRDVNTKYTQVQQNITISNILGLDASPYFNFSDdr 243
Cdd:cd00091    1 LQYGRPGVLADTEVLSYTHYVLSYNRATRLPLWVAEHIDKEDL--GKNVDRKYDQFKQDPRIPPLFSATNSDYKGSGS-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  244 iLSRGHMIAKTDQIF-GAAQHTTFLFINVAPQWQTFNGGNWEKVETSVRKFVADRNLTTDCYTGTWGVSTLPDVDGIere 322
Cdd:cd00091   77 -LDRGHLAPAADPVWsQDAQDATFYLTNMAPQVQGFNQGNWAYLEDYLRDLAASEGKDVYVVTGPLFLPDLDGDGGS--- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  323 lYLDFDENNNGLIPVPKIYFRVVIDRV----TREGIVLIGINNPYLTLEQiqkdyILCQDIGHQLSWLTWYKEdlhEGYS 398
Cdd:cd00091  153 -YLSTQVINNGKVAVPTHFWKVIIDEKapgnLSVGAFVLPNNNPHDTLEF-----ILCVEKTFQVPVASVEKA---TGLS 223

                        250
                 ....*....|....*...
gi 24663552  399 YACSVEDFIEVVKDLPLE 416
Cdd:cd00091  224 FFCNVPDSVSAVLELKKK 241
NUC cd00091
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 1111-1359 9.67e-70

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.


Pssm-ID: 238043  Cd Length: 241  Bit Score: 234.19  E-value: 9.67e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552 1111 TYDVCHDELSEVTRYVHHVLYPGSDQYQRSVSRPSFIPGDFygGKDVNTLYTQVQQNITVSEILGMDASPYFNTTGnvyL 1190
Cdd:cd00091    3 YGRPGVLADTEVLSYTHYVLSYNRATRLPLWVAEHIDKEDL--GKNVDRKYDQFKQDPRIPPLFSATNSDYKGSGS---L 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552 1191 ARGHLSAKTDFVF-GAAQKASFFFVNAAPQWQTFNGGNWERIEDSVRKFVADENITVDCYTGTWGVSTLPDVNGIgrelY 1269
Cdd:cd00091   78 DRGHLAPAADPVWsQDAQDATFYLTNMAPQVQGFNQGNWAYLEDYLRDLAASEGKDVYVVTGPLFLPDLDGDGGS----Y 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552 1270 LDFDENNNGLIPVPKLYFRVIIDR----ESRNGIVLLGVNNPHATieqieEEYIICQDIGAQLSWVSWTKedlKKGYSYA 1345
Cdd:cd00091  154 LSTQVINNGKVAVPTHFWKVIIDEkapgNLSVGAFVLPNNNPHDT-----LEFILCVEKTFQVPVASVEK---ATGLSFF 225

                        250
                 ....*....|....
gi 24663552 1346 CTVEDFTAVVKDLP 1359
Cdd:cd00091  226 CNVPDSVSAVLELK 239
Endonuclease_NS pfam01223
DNA/RNA non-specific endonuclease;
1089-1351 2.19e-48

DNA/RNA non-specific endonuclease;


Pssm-ID: 460120  Cd Length: 220  Bit Score: 171.85  E-value: 2.19e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552   1089 GGTDLLEVGFQLSSSSSDDFLQTYDVCHDELSEVTRYVHHVLYPGSDQYQRSVSRPSFIPGDFYGGKDVNTLYTQVQQNi 1168
Cdd:pfam01223    1 NSGTLFKVGFPGSGSDVVLFYKYYSLCYDRRTRRALWVAHHLTGASLAGSKGRRRPGFKQDPRIPGAYFRTLYTDYTGS- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552   1169 tvseilGMDaspyfnttgnvylaRGHLSAKTDFVFGA-AQKASFFFVNAAPQWQTFNGGNWERIEDSVRKFVADENITVD 1247
Cdd:pfam01223   80 ------GFD--------------RGHLAPAADFKFSAgANAATFNFTNIAPQWAGFNQGNWAYLENYVRDLAARHNNSVY 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552   1248 CYTGTWGVSTLPDVNGigrelyldfdennnglIPVPKLYFRVIIDRESRNGivlLGVNNPHATIEQieeeyiicQDIGAQ 1327
Cdd:pfam01223  140 VYTGPLYVPNLLDKNK----------------VAVPTHFWKVILSEDGDGG---GGLNAPAFVLPN--------KYILDD 192

                          250       260
                   ....*....|....*....|....*....
gi 24663552   1328 LSWVSW-----TKEDLkKGYSYACTVEDF 1351
Cdd:pfam01223  193 GPLRTFqvpvdELERL-TGLDFCCGVPDA 220
Endonuclease_NS smart00892
DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share ...
 1112-1350 1.01e-40

DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. An histidine has been shown to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.


Pssm-ID: 214889 [Multi-domain]  Cd Length: 198  Bit Score: 149.10  E-value: 1.01e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    1112 YDVCHDELSEVTRYVHHVLYPGSDQY-QRSVSRPSFIPGDfyggkdvntlytqvqqnITVSEILGMDASPYFNTtgnvYL 1190
Cdd:smart00892    4 YALCYDERRRLPLWVAYHLTGSTRQGkNTGRKRPWFKPDG-----------------WHLPAIFQAVNSDYTGS----GY 62

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    1191 ARGHLSAKTD-FVFGAAQKASFFFVNAAPQWQTFNGGNWERIEDSVRKFVADENITVDCYTGTWGVSTLPDVNgigrely 1269
Cdd:smart00892   63 DRGHLAPAADhGVSQEAMAATFYLTNIVPQTAGFNQGNWNRLENYVRKLLAKNKDTVYVVTGPIYLPTLPDNN------- 135

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    1270 ldfdennnglIPVPKLYFRVIID-RESRNGIVLLGVNNPHATIEQIEEEyiicQDIGAQLSWVSWtkedlKKGYSYACTV 1348
Cdd:smart00892  136 ----------VAVPSHFWKVILSeDGSNGGLAAIAFNLPNAPINEDYPL----CEFQVPVDNIER-----LTGLDFFCGL 196


                    ..
gi 24663552    1349 ED 1350
Cdd:smart00892  197 PD 198
Endonuclease_NS pfam01223
DNA/RNA non-specific endonuclease;
147-406 9.90e-39

DNA/RNA non-specific endonuclease;


Pssm-ID: 460120  Cd Length: 220  Bit Score: 144.12  E-value: 9.90e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    147 GGTDLVQVGFEVEDGG---FLQSYELCHDAEAEATRYVHHVLYPSSYDYQHGVARPNFLELDFYGGRDVNTKYTQVQQNi 223
Cdd:pfam01223    1 NSGTLFKVGFPGSGSDvvlFYKYYSLCYDRRTRRALWVAHHLTGASLAGSKGRRRPGFKQDPRIPGAYFRTLYTDYTGS- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    224 tisnilGLDaspyfnfsddrilsRGHMIAKTDQIFGA-AQHTTFLFINVAPQWQTFNGGNWEKVETSVRKFVADRNLTTD 302
Cdd:pfam01223   80 ------GFD--------------RGHLAPAADFKFSAgANAATFNFTNIAPQWAGFNQGNWAYLENYVRDLAARHNNSVY 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    303 CYTGTWGVSTLPDvdgierelyldfdennNGLIPVPKIYFRVVIDRVTREGivlIGINNPYLTLEQiqkdyilcQDIGHQ 382
Cdd:pfam01223  140 VYTGPLYVPNLLD----------------KNKVAVPTHFWKVILSEDGDGG---GGLNAPAFVLPN--------KYILDD 192

                          250       260
                   ....*....|....*....|....*....
gi 24663552    383 LSWLTWY-----KEDLHeGYSYACSVEDF 406
Cdd:pfam01223  193 GPLRTFQvpvdeLERLT-GLDFCCGVPDA 220
Endonuclease_NS smart00892
DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share ...
 167-405 1.70e-36

DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. An histidine has been shown to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.


Pssm-ID: 214889 [Multi-domain]  Cd Length: 198  Bit Score: 137.15  E-value: 1.70e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     167 YELCHDAEAEATRYVHHVLYPSS-YDYQHGVARPNFLELDfyggrdvntkytqvqqnITISNILGLDASPYFNfsddRIL 245
Cdd:smart00892    4 YALCYDERRRLPLWVAYHLTGSTrQGKNTGRKRPWFKPDG-----------------WHLPAIFQAVNSDYTG----SGY 62

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     246 SRGHMIAKTD-QIFGAAQHTTFLFINVAPQWQTFNGGNWEKVETSVRKFVADRNLTTDCYTGTWGVSTLPDVDgierely 324
Cdd:smart00892   63 DRGHLAPAADhGVSQEAMAATFYLTNIVPQTAGFNQGNWNRLENYVRKLLAKNKDTVYVVTGPIYLPTLPDNN------- 135

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     325 ldfdennnglIPVPKIYFRVVID-RVTREGIVLIGINNPYLTleqIQKDYILCqDIGHQLSWLTWYKedlheGYSYACSV 403
Cdd:smart00892  136 ----------VAVPSHFWKVILSeDGSNGGLAAIAFNLPNAP---INEDYPLC-EFQVPVDNIERLT-----GLDFFCGL 196


                    ..
gi 24663552     404 ED 405
Cdd:smart00892  197 PD 198
NUC cd00091
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 718-967 1.06e-33

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.


Pssm-ID: 238043  Cd Length: 241  Bit Score: 130.57  E-value: 1.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  718 LSHVELCYDQQEQISRYARYELTPANVAYQKGVAQPGYLRGDFysGEDVNVLYDQSHQLDAFSTALGLDASQYFDSTKdl 797
Cdd:cd00091    1 LQYGRPGVLADTEVLSYTHYVLSYNRATRLPLWVAEHIDKEDL--GKNVDRKYDQFKQDPRIPPLFSATNSDYKGSGS-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  798 yLTRGQLAARLDFV-HSSAQRATHFYVNAVPQWRSINIGNWLAVESSLKQFVADEALNVSVHAGSYDISTLPNSQGVQTP 876
Cdd:cd00091   77 -LDRGHLAPAADPVwSQDAQDATFYLTNMAPQVQGFNQGNWAYLEDYLRDLAASEGKDVYVVTGPLFLPDLDGDGGSYLS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  877 LYLNAETKqLPVAKILYRIVID----QESRKGVVLIVVNNPHITLTETLedyviCEDVGAQIDWLDWDKANlqkGYSYAC 952
Cdd:cd00091  156 TQVINNGK-VAVPTHFWKVIIDekapGNLSVGAFVLPNNNPHDTLEFIL-----CVEKTFQVPVASVEKAT---GLSFFC 226

                        250
                 ....*....|....*
gi 24663552  953 SVEDFIEVVKDLPTD 967
Cdd:cd00091  227 NVPDSVSAVLELKKK 241
Endonuclease_NS smart00892
DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share ...
 720-956 4.28e-29

DNA/RNA non-specific endonuclease; A family of bacterial and eukaryotic endonucleases share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. An histidine has been shown to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.


Pssm-ID: 214889 [Multi-domain]  Cd Length: 198  Bit Score: 115.58  E-value: 4.28e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     720 HVELCYDQQEQISRYARYELTPANVAY-QKGVAQPgylrgDFYSGEDVNVLYDQShqldafstalglDASQYFDStkdlY 798
Cdd:smart00892    3 HYALCYDERRRLPLWVAYHLTGSTRQGkNTGRKRP-----WFKPDGWHLPAIFQA------------VNSDYTGS----G 61

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     799 LTRGQLAAR-LDFVHSSAQRATHFYVNAVPQWRSINIGNWLAVESSLKQFVADEALNVSVHAGSYDISTLPNsqgvqtpl 877
Cdd:smart00892   62 YDRGHLAPAaDHGVSQEAMAATFYLTNIVPQTAGFNQGNWNRLENYVRKLLAKNKDTVYVVTGPIYLPTLPD-------- 133

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     878 ylnaetKQLPVAKILYRIVID-QESRKGVVLIVVNNPHITlteTLEDYVICEdVGAQIDWLDWdkanlQKGYSYACSVED 956
Cdd:smart00892  134 ------NNVAVPSHFWKVILSeDGSNGGLAAIAFNLPNAP---INEDYPLCE-FQVPVDNIER-----LTGLDFFCGLPD 198
Endonuclease_NS pfam01223
DNA/RNA non-specific endonuclease;
702-957 3.42e-27

DNA/RNA non-specific endonuclease;


Pssm-ID: 460120  Cd Length: 220  Bit Score: 110.99  E-value: 3.42e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    702 GGTDVVHIGFDVAAG----FLSHVELCYDQQEQISRYARYELTPANVAYQKGVAQPGYLRGDFYSGEDVNVLYDQShqld 777
Cdd:pfam01223    1 NSGTLFKVGFPGSGSdvvlFYKYYSLCYDRRTRRALWVAHHLTGASLAGSKGRRRPGFKQDPRIPGAYFRTLYTDY---- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    778 afsTALGLDasqyfdstkdlyltRGQLAARLDFVHSS-AQRATHFYVNAVPQWRSINIGNWLAVESSLKQFVADEALNVS 856
Cdd:pfam01223   77 ---TGSGFD--------------RGHLAPAADFKFSAgANAATFNFTNIAPQWAGFNQGNWAYLENYVRDLAARHNNSVY 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    857 VHAGSYDISTLPNSQGVQTPLYlnaetkqlpvakiLYRIVIDQESRKGVvliVVNNPHITLTEtledyvicEDVGAQIDW 936
Cdd:pfam01223  140 VYTGPLYVPNLLDKNKVAVPTH-------------FWKVILSEDGDGGG---GLNAPAFVLPN--------KYILDDGPL 195

                          250       260
                   ....*....|....*....|....*
gi 24663552    937 LDW----DKANLQKGYSYACSVEDF 957
Cdd:pfam01223  196 RTFqvpvDELERLTGLDFCCGVPDA 220
NUC1 COG1864
DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism];
1192-1298 1.60e-11

DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism];


Pssm-ID: 441469  Cd Length: 238  Bit Score: 65.70  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552 1192 RGHLSAKTDFVFG-AAQKASFFFVNAAPQWQTFNGGNWERIEDSVRKFV-ADENITVdcYTGtwGVSTLPDVNGIGrely 1269
Cdd:COG1864   90 RGHLAPSADRTFSkEANSETFLMTNISPQAPDFNQGIWARLENYVRDLArKGGEVYV--VTG--PVFDDGDLKTIG---- 161

                         90       100
                 ....*....|....*....|....*....
gi 24663552 1270 ldfdennNGLIPVPKLYFRVIIDRESRNG 1298
Cdd:COG1864  162 -------SGGVAVPTAFWKVVVDPDKNTG 183
NUC smart00477
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 1186-1309 2.13e-09

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases


Pssm-ID: 214683  Cd Length: 210  Bit Score: 58.91  E-value: 2.13e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552    1186 GNVYLARGHLSAKTDFVFGA-AQKASFFFVNAAPQWQTFNGGNWERIEDSVRKFVADENITVDCYTGTwgvSTLPDVNGI 1264
Cdd:smart00477   56 KGSGYDRGHLAPAADHKFSSeAMADTFYLSNIVPQYPDFNRGAWAYLEDYLRKLTASERNGVYVVSGP---LFLPNYDGK 132

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 24663552    1265 GRELYLDFDENNNGLIPVPKLYFRVIIDRESRNGIVLLGVNNPHA 1309
Cdd:smart00477  133 GDKLEVKYQVIGSKNVAIPTHFFKVITAEKADSYLEVAAFILPND 177
NUC1 COG1864
DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism];
172-347 2.01e-07

DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism];


Pssm-ID: 441469  Cd Length: 238  Bit Score: 53.76  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  172 DAEAEATRYVHHVLYPSSYDYQHGVarPNFleldfyggrdvntkytqVQQNITISNILG-LDASPYFnFSDDRI------ 244
Cdd:COG1864   19 RALSTNNYLLCYTGYSLSYNESRRT--PNW-----------------VAYNLDGSWLGKsLKRSDDF-RPDPRLpsgyra 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552  245 ---------LSRGHMIAKTDQIFG-AAQHTTFLFINVAPQWQTFNGGNWEKVETSVRKFVADRNlttDCY--TGtwGVST 312
Cdd:COG1864   79 tladytgsgYDRGHLAPSADRTFSkEANSETFLMTNISPQAPDFNQGIWARLENYVRDLARKGG---EVYvvTG--PVFD 153

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 24663552  313 LPDVDGIerelyldfdenNNGLIPVPKIYFRVVID 347
Cdd:COG1864  154 DGDLKTI-----------GSGGVAVPTAFWKVVVD 177
NUC smart00477
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 245-346 1.09e-06

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases


Pssm-ID: 214683  Cd Length: 210  Bit Score: 50.82  E-value: 1.09e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     245 LSRGHMIAKTDQIFGA-AQHTTFLFINVAPQWQTFNGGNWEKVEtsvrKFVadRNLTTDCYTGTWGVS---TLPDVDGIE 320
Cdd:smart00477   60 YDRGHLAPAADHKFSSeAMADTFYLSNIVPQYPDFNRGAWAYLE----DYL--RKLTASERNGVYVVSgplFLPNYDGKG 133

                            90       100
                    ....*....|....*....|....*.
gi 24663552     321 RELYLDFDENNNGLIPVPKIYFRVVI 346
Cdd:smart00477  134 DKLEVKYQVIGSKNVAIPTHFFKVIT 159
NUC smart00477
DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA ...
 723-860 1.66e-04

DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases


Pssm-ID: 214683  Cd Length: 210  Bit Score: 44.27  E-value: 1.66e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     723 LCYDQQEQISRYARYELTPAnvayqkGVAQPGYLRGDFYSgEDVNV-LYDQSHQLDafstalgldasqYFDStkdlYLTR 801
Cdd:smart00477    6 LGYNRSTRMPNWVAYHITGE------LLTSGAERKSDCFK-PDTRIpEKFQAKLSD------------YKGS----GYDR 62

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663552     802 GQLAARLDFVHSS-AQRATHFYVNAVPQWRSINIGNWLAVESSLKQFVADEALNVSVHAG 860
Cdd:smart00477   63 GHLAPAADHKFSSeAMADTFYLSNIVPQYPDFNRGAWAYLEDYLRKLTASERNGVYVVSG 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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