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Conserved domains on  [gi|21355683|ref|NP_648255|]
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Acyl-CoA binding protein 5 [Drosophila melanogaster]

Protein Classification

acyl-CoA-binding protein( domain architecture ID 1012)

acyl-CoA-binding protein binds acyl-CoA esters and may play a role in housekeeping and/or trafficking

CATH:  1.20.80.10
Gene Ontology:  GO:0000062
PubMed:  16018771
SCOP:  4000745

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ACBP super family cl00221
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 2-76 3.94e-20

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


The actual alignment was detected with superfamily member cd00435:

Pssm-ID: 469667  Cd Length: 85  Bit Score: 76.21  E-value: 3.94e-20
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21355683  2 ADFNAILEKTKAFSKKPPTEVYLEFYGLYKQFQEGDINIEKPA--DAEGAAKYDAWLSRKGLSVDDAKAAYVALYEK 76
Cdd:cd00435  3 EEFEAAAEKVKKLKTKPSNEEKLQLYSLYKQATVGDCNTERPGmfDLKGRAKWDAWNSLKGMSKEDAMKAYIAKVEE 79
 
Name Accession Description Interval E-value
ACBP cd00435
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 2-76 3.94e-20

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


Pssm-ID: 238248  Cd Length: 85  Bit Score: 76.21  E-value: 3.94e-20
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21355683  2 ADFNAILEKTKAFSKKPPTEVYLEFYGLYKQFQEGDINIEKPA--DAEGAAKYDAWLSRKGLSVDDAKAAYVALYEK 76
Cdd:cd00435  3 EEFEAAAEKVKKLKTKPSNEEKLQLYSLYKQATVGDCNTERPGmfDLKGRAKWDAWNSLKGMSKEDAMKAYIAKVEE 79
ACB COG4281
Acyl-CoA-binding protein [Lipid transport and metabolism];
2-77 2.13e-19

Acyl-CoA-binding protein [Lipid transport and metabolism];


Pssm-ID: 443422  Cd Length: 87  Bit Score: 74.50  E-value: 2.13e-19
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21355683  2 ADFNAILEKTKAFSKKPPTEVYLEFYGLYKQFQEGDINIEKP--ADAEGAAKYDAWLSRKGLSVDDAKAAYVALYEKY 77
Cdd:COG4281  6 AAFEAAVARVKTLTERPDNDTLLKLYALYKQATEGDVTGKRPgmTDFVGRAKYDAWAQLKGMSKDEAMQQYIDLVNSL 83
ACBP pfam00887
Acyl CoA binding protein;
1-73 5.76e-18

Acyl CoA binding protein;


Pssm-ID: 459982  Cd Length: 76  Bit Score: 70.70  E-value: 5.76e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355683    1 MADFNAILEKTKAFSKKPPTEVYLEFYGLYKQFQEGDINIEKPA--DAEGAAKYDAWLSRKGLSVDDAKAAYVAL 73
Cdd:pfam00887  1 EEKFEAAAEFVKKLKSKPSNEEKLELYGLYKQATVGDCNTPRPGmfDFKGKAKWDAWKKLGGMSKEEAMAKYVEL 75
PTZ00458 PTZ00458
acyl CoA binding protein; Provisional
 19-81 6.25e-05

acyl CoA binding protein; Provisional


Pssm-ID: 185637  Cd Length: 90  Bit Score: 37.88  E-value: 6.25e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355683  19 PTEVYLEFYGLYKQFQEGDINIEKPA--DAEGAAKYDAWLSRKGLSVDDAKAAYVALYEKYNPIY 81
Cdd:PTZ00458 22 SVEIKLDLYKYYKQSTVGNCNIKEPSmfKYQDRKKYEAWKSIENLNREDAKKRYVEIVTELFPNW 86
 
Name Accession Description Interval E-value
ACBP cd00435
Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a ...
 2-76 3.94e-20

Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.


Pssm-ID: 238248  Cd Length: 85  Bit Score: 76.21  E-value: 3.94e-20
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21355683  2 ADFNAILEKTKAFSKKPPTEVYLEFYGLYKQFQEGDINIEKPA--DAEGAAKYDAWLSRKGLSVDDAKAAYVALYEK 76
Cdd:cd00435  3 EEFEAAAEKVKKLKTKPSNEEKLQLYSLYKQATVGDCNTERPGmfDLKGRAKWDAWNSLKGMSKEDAMKAYIAKVEE 79
ACB COG4281
Acyl-CoA-binding protein [Lipid transport and metabolism];
2-77 2.13e-19

Acyl-CoA-binding protein [Lipid transport and metabolism];


Pssm-ID: 443422  Cd Length: 87  Bit Score: 74.50  E-value: 2.13e-19
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21355683  2 ADFNAILEKTKAFSKKPPTEVYLEFYGLYKQFQEGDINIEKP--ADAEGAAKYDAWLSRKGLSVDDAKAAYVALYEKY 77
Cdd:COG4281  6 AAFEAAVARVKTLTERPDNDTLLKLYALYKQATEGDVTGKRPgmTDFVGRAKYDAWAQLKGMSKDEAMQQYIDLVNSL 83
ACBP pfam00887
Acyl CoA binding protein;
1-73 5.76e-18

Acyl CoA binding protein;


Pssm-ID: 459982  Cd Length: 76  Bit Score: 70.70  E-value: 5.76e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355683    1 MADFNAILEKTKAFSKKPPTEVYLEFYGLYKQFQEGDINIEKPA--DAEGAAKYDAWLSRKGLSVDDAKAAYVAL 73
Cdd:pfam00887  1 EEKFEAAAEFVKKLKSKPSNEEKLELYGLYKQATVGDCNTPRPGmfDFKGKAKWDAWKKLGGMSKEEAMAKYVEL 75
PTZ00458 PTZ00458
acyl CoA binding protein; Provisional
 19-81 6.25e-05

acyl CoA binding protein; Provisional


Pssm-ID: 185637  Cd Length: 90  Bit Score: 37.88  E-value: 6.25e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355683  19 PTEVYLEFYGLYKQFQEGDINIEKPA--DAEGAAKYDAWLSRKGLSVDDAKAAYVALYEKYNPIY 81
Cdd:PTZ00458 22 SVEIKLDLYKYYKQSTVGNCNIKEPSmfKYQDRKKYEAWKSIENLNREDAKKRYVEIVTELFPNW 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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