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Conserved domains on  [gi|24659653|ref|NP_648065|]
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uncharacterized protein Dmel_CG10064 [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455469)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 366-650 1.44e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 156.34  E-value: 1.44e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 366 HTKSVYCITFPKNYSGVFATSGKECIRIWSSGRKQELLRIMVYNFNCACVRFTHDGTSIVSVWNDGIIRAFTPITGRLIY 445
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 446 AIpNAHNKGCSALAVASSGRLIVTGGIEGQVRVWKIDPYRQdlVGVLKDHSGPITSLDINYLDTEVISACTDGSCVIWDI 525
Cdd:cd00200  88 TL-TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC--LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 526 KRMTRKQVVTANTQFM-SASYFPTGVQVITCGSDGRIIYWMVYNGALIRELTaSKKSSVNCLAINETGDYFITVGSDLQV 604
Cdd:cd00200 165 RTGKCVATLTGHTGEVnSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDGTI 243

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 24659653 605 KLWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWD 650
Cdd:cd00200 244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
59-482 5.73e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 5.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  59 GHTNTISCLDLSKSGKYMASGqinhmGFRGYVIIWNYDQRKEIARHDLHKVSVQAICFTAQDRCVVSigGVDDGSVIVFD 138
Cdd:COG2319 118 GHTGAVRSVAFSPDGKTLASG-----SADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 139 MEAFSPIcQTPASRAISGNALTVRPlhNNPYFFVTAGDRHLRLWSIlreekklyvqdvlmasktrvfycarinktdefay 218
Cdd:COG2319 191 LATGKLL-RTLTGHTGAVRSVAFSP--DGKLLASGSADGTVRLWDL---------------------------------- 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 219 lgtGTGDIVKIvlnccdrdhvskqgstscilgaFGTHNprkptgrdcnryvNGVRALYVLEGGRLLIGAG-NGDIELvee 297
Cdd:COG2319 234 ---ATGKLLRT----------------------LTGHS-------------GSVRSVAFSPDGRLLASGSaDGTVRL--- 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 298 rtdvplinfrdypgptWpylrtlkkthvsgrissfvrsktdmfyictdtneiyglNIKTWVLKLLRTCHTKSVYCITFPK 377
Cdd:COG2319 273 ----------------W--------------------------------------DLATGELLRTLTGHSGGVNSVAFSP 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 378 NySGVFATSGKEC-IRIWSSGRKQELLRIMVYNFNCACVRFTHDGTSIVSVWNDGIIRAFTPITGRLIYAIpNAHNKGCS 456
Cdd:COG2319 299 D-GKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGAVT 376

                       410       420
                ....*....|....*....|....*.
gi 24659653 457 ALAVASSGRLIVTGGIEGQVRVWKID 482
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 366-650 1.44e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 156.34  E-value: 1.44e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 366 HTKSVYCITFPKNYSGVFATSGKECIRIWSSGRKQELLRIMVYNFNCACVRFTHDGTSIVSVWNDGIIRAFTPITGRLIY 445
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 446 AIpNAHNKGCSALAVASSGRLIVTGGIEGQVRVWKIDPYRQdlVGVLKDHSGPITSLDINYLDTEVISACTDGSCVIWDI 525
Cdd:cd00200  88 TL-TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC--LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 526 KRMTRKQVVTANTQFM-SASYFPTGVQVITCGSDGRIIYWMVYNGALIRELTaSKKSSVNCLAINETGDYFITVGSDLQV 604
Cdd:cd00200 165 RTGKCVATLTGHTGEVnSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDGTI 243

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 24659653 605 KLWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWD 650
Cdd:cd00200 244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
353-652 1.20e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 1.20e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 353 NIKTWVLKLLRTCHTKSVYCITFPKNYSGVFATSGKECIRIWSSGRKQELLRIMVYNFNCACVRFTHDGTSIVSVWNDGI 432
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 433 IRAFTPITGRLIYAIPnAHNKGCSALAVASSGRLIVTGGIEGQVRVWkiDPYRQDLVGVLKDHSGPITSLDINYLDTEVI 512
Cdd:COG2319 186 VRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 513 SACTDGSCVIWDIKRMTRKQVVTANTQF-MSASYFPTGVQVITCGSDGRIIYWMVYNGALIRELTASKkSSVNCLAINET 591
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT-GAVRSVAFSPD 341

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24659653 592 GDYFITVGSDLQVKLWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWDVP 652
Cdd:COG2319 342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
59-482 5.73e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 5.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  59 GHTNTISCLDLSKSGKYMASGqinhmGFRGYVIIWNYDQRKEIARHDLHKVSVQAICFTAQDRCVVSigGVDDGSVIVFD 138
Cdd:COG2319 118 GHTGAVRSVAFSPDGKTLASG-----SADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 139 MEAFSPIcQTPASRAISGNALTVRPlhNNPYFFVTAGDRHLRLWSIlreekklyvqdvlmasktrvfycarinktdefay 218
Cdd:COG2319 191 LATGKLL-RTLTGHTGAVRSVAFSP--DGKLLASGSADGTVRLWDL---------------------------------- 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 219 lgtGTGDIVKIvlnccdrdhvskqgstscilgaFGTHNprkptgrdcnryvNGVRALYVLEGGRLLIGAG-NGDIELvee 297
Cdd:COG2319 234 ---ATGKLLRT----------------------LTGHS-------------GSVRSVAFSPDGRLLASGSaDGTVRL--- 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 298 rtdvplinfrdypgptWpylrtlkkthvsgrissfvrsktdmfyictdtneiyglNIKTWVLKLLRTCHTKSVYCITFPK 377
Cdd:COG2319 273 ----------------W--------------------------------------DLATGELLRTLTGHSGGVNSVAFSP 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 378 NySGVFATSGKEC-IRIWSSGRKQELLRIMVYNFNCACVRFTHDGTSIVSVWNDGIIRAFTPITGRLIYAIpNAHNKGCS 456
Cdd:COG2319 299 D-GKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGAVT 376

                       410       420
                ....*....|....*....|....*.
gi 24659653 457 ALAVASSGRLIVTGGIEGQVRVWKID 482
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-188 9.36e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 9.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  25 NGVRQHPvTGSIIFALG--NKIGIADYKKNTQEFV-AGHTNTISCLDLSKSGKYMASGQINhmgfrGYVIIWNYDQRKEI 101
Cdd:cd00200  97 SSVAFSP-DGRILSSSSrdKTIKVWDVETGKCLTTlRGHTDWVNSVAFSPDGTFVASSSQD-----GTIKLWDLRTGKCV 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 102 ARHDLHKVSVQAICFTAQDRCVVSigGVDDGSVIVFDMEAFSPICQTPASRAIsgnALTVRPLHNNPYFFVTAGDRHLRL 181
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENG---VNSVAFSPDGYLLASGSEDGTIRV 245


                ....*..
gi 24659653 182 WSILREE 188
Cdd:cd00200 246 WDLRTGE 252
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 449-651 1.58e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.54  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  449 NAHNKGCsALAVASSGRLIVTGGIEGQVRVWKIDPYRQDLvgvlKDHSGPITSLDI----------NYLDTEVISACTDG 518
Cdd:PLN00181 481 NSSNLVC-AIGFDRDGEFFATAGVNKKIKIFECESIIKDG----RDIHYPVVELASrsklsgicwnSYIKSQVASSNFEG 555

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  519 SCVIWDIkrmTRKQVVTA----NTQFMSASYFPTGVQVITCGSD-GRIIYWMVYNGALIRelTASKKSSVNCLAI-NETG 592
Cdd:PLN00181 556 VVQVWDV---ARSQLVTEmkehEKRVWSIDYSSADPTLLASGSDdGSVKLWSINQGVSIG--TIKTKANICCVQFpSESG 630

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24659653  593 DYFITVGSDLQVKLWDYNSGAV---VGIGseHASSVISCAYSPCMTMfVTGSTDGSLIIWDV 651
Cdd:PLN00181 631 RSLAFGSADHKVYYYDLRNPKLplcTMIG--HSKTVSYVRFVDSSTL-VSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 611-650 3.85e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 3.85e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24659653    611 SGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWD 650
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
612-650 5.89e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24659653   612 GAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWD 650
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 366-650 1.44e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 156.34  E-value: 1.44e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 366 HTKSVYCITFPKNYSGVFATSGKECIRIWSSGRKQELLRIMVYNFNCACVRFTHDGTSIVSVWNDGIIRAFTPITGRLIY 445
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 446 AIpNAHNKGCSALAVASSGRLIVTGGIEGQVRVWKIDPYRQdlVGVLKDHSGPITSLDINYLDTEVISACTDGSCVIWDI 525
Cdd:cd00200  88 TL-TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC--LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 526 KRMTRKQVVTANTQFM-SASYFPTGVQVITCGSDGRIIYWMVYNGALIRELTaSKKSSVNCLAINETGDYFITVGSDLQV 604
Cdd:cd00200 165 RTGKCVATLTGHTGEVnSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDGTI 243

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 24659653 605 KLWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWD 650
Cdd:cd00200 244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
353-652 1.20e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 1.20e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 353 NIKTWVLKLLRTCHTKSVYCITFPKNYSGVFATSGKECIRIWSSGRKQELLRIMVYNFNCACVRFTHDGTSIVSVWNDGI 432
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 433 IRAFTPITGRLIYAIPnAHNKGCSALAVASSGRLIVTGGIEGQVRVWkiDPYRQDLVGVLKDHSGPITSLDINYLDTEVI 512
Cdd:COG2319 186 VRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 513 SACTDGSCVIWDIKRMTRKQVVTANTQF-MSASYFPTGVQVITCGSDGRIIYWMVYNGALIRELTASKkSSVNCLAINET 591
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT-GAVRSVAFSPD 341

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24659653 592 GDYFITVGSDLQVKLWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWDVP 652
Cdd:COG2319 342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
352-651 3.03e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.76  E-value: 3.03e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 352 LNIKTWVLKLLRTCHTKSVYCITFPKNYSGVFATSGKECIRIWSSGRKQELLRIMVYNFNCACVRFTHDGTSIVSVWNDG 431
Cdd:COG2319  63 LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 432 IIRAFTPITGRLIYAIpNAHNKGCSALAVASSGRLIVTGGIEGQVRVWkiDPYRQDLVGVLKDHSGPITSLDINYLDTEV 511
Cdd:COG2319 143 TVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLRTLTGHTGAVRSVAFSPDGKLL 219

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 512 ISACTDGSCVIWDIKRMTRKQVVTANTQF-MSASYFPTGVQVITCGSDGRIIYWMVYNGALIRELTASKkSSVNCLAINE 590
Cdd:COG2319 220 ASGSADGTVRLWDLATGKLLRTLTGHSGSvRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS-GGVNSVAFSP 298

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24659653 591 TGDYFITVGSDLQVKLWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWDV 651
Cdd:COG2319 299 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
415-651 6.72e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 6.72e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 415 VRFTHDGTSIVSVWNDGIIRAFTPITGRLIyAIPNAHNKGCSALAVASSGRLIVTGGIEGQVRVWKIDpyRQDLVGVLKD 494
Cdd:COG2319  42 LAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA--TGLLLRTLTG 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 495 HSGPITSLDINYLDTEVISACTDGSCVIWDIKRMTRKQVVTANTQFM-SASYFPTGVQVITCGSDGRIIYWMVYNGALIR 573
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVtSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24659653 574 ELTASKkSSVNCLAINETGDYFITVGSDLQVKLWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWDV 651
Cdd:COG2319 199 TLTGHT-GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 488-651 5.32e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.72  E-value: 5.32e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 488 LVGVLKDHSGPITSLDINYLDTEVISACTDGSCVIWDIKRMTRKQVVTANTQFMSA-SYFPTGVQVITCGSDGRIIYWMV 566
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 567 YNGALIRELTASkKSSVNCLAINETGDYFITVGSDLQVKLWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSL 646
Cdd:cd00200  81 ETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159


                ....*
gi 24659653 647 IIWDV 651
Cdd:cd00200 160 KLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
416-651 1.75e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 1.75e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 416 RFTHDGTSIVSVWNDGIIRAFTPITGRLIyAIPNAHNKGCSALAVASSGRLIVTGGIEGQVRVWkiDPYRQDLVGVLKDH 495
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALL-LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLL--DAAAGALLATLLGH 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 496 SGPITSLDINYLDTEVISACTDGSCVIWDIKRMTRKQVVTANT-QFMSASYFPTGVQVITCGSDGRIIYWMVYNGALIRE 574
Cdd:COG2319  78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTgAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24659653 575 LTAsKKSSVNCLAINETGDYFITVGSDLQVKLWDYNSGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWDV 651
Cdd:COG2319 158 LTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 541-652 1.18e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 1.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 541 MSASYFPTGVQVITCGSDGRIIYWMVYNGALIRELTASKKSSVNCLAINeTGDYFITVGSDLQVKLWDYNSGAVVGIGSE 620
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGECVRTLTG 91

                        90       100       110
                ....*....|....*....|....*....|..
gi 24659653 621 HASSVISCAYSPCMTMFVTGSTDGSLIIWDVP 652
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
59-482 5.73e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 5.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  59 GHTNTISCLDLSKSGKYMASGqinhmGFRGYVIIWNYDQRKEIARHDLHKVSVQAICFTAQDRCVVSigGVDDGSVIVFD 138
Cdd:COG2319 118 GHTGAVRSVAFSPDGKTLASG-----SADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS--GSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 139 MEAFSPIcQTPASRAISGNALTVRPlhNNPYFFVTAGDRHLRLWSIlreekklyvqdvlmasktrvfycarinktdefay 218
Cdd:COG2319 191 LATGKLL-RTLTGHTGAVRSVAFSP--DGKLLASGSADGTVRLWDL---------------------------------- 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 219 lgtGTGDIVKIvlnccdrdhvskqgstscilgaFGTHNprkptgrdcnryvNGVRALYVLEGGRLLIGAG-NGDIELvee 297
Cdd:COG2319 234 ---ATGKLLRT----------------------LTGHS-------------GSVRSVAFSPDGRLLASGSaDGTVRL--- 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 298 rtdvplinfrdypgptWpylrtlkkthvsgrissfvrsktdmfyictdtneiyglNIKTWVLKLLRTCHTKSVYCITFPK 377
Cdd:COG2319 273 ----------------W--------------------------------------DLATGELLRTLTGHSGGVNSVAFSP 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 378 NySGVFATSGKEC-IRIWSSGRKQELLRIMVYNFNCACVRFTHDGTSIVSVWNDGIIRAFTPITGRLIYAIpNAHNKGCS 456
Cdd:COG2319 299 D-GKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGAVT 376

                       410       420
                ....*....|....*....|....*.
gi 24659653 457 ALAVASSGRLIVTGGIEGQVRVWKID 482
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-188 9.36e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 9.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  25 NGVRQHPvTGSIIFALG--NKIGIADYKKNTQEFV-AGHTNTISCLDLSKSGKYMASGQINhmgfrGYVIIWNYDQRKEI 101
Cdd:cd00200  97 SSVAFSP-DGRILSSSSrdKTIKVWDVETGKCLTTlRGHTDWVNSVAFSPDGTFVASSSQD-----GTIKLWDLRTGKCV 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 102 ARHDLHKVSVQAICFTAQDRCVVSigGVDDGSVIVFDMEAFSPICQTPASRAIsgnALTVRPLHNNPYFFVTAGDRHLRL 181
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENG---VNSVAFSPDGYLLASGSEDGTIRV 245


                ....*..
gi 24659653 182 WSILREE 188
Cdd:cd00200 246 WDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-480 6.27e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 6.27e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 354 IKTWVLKLLRTC-----HTKSVYCITFPKNYSGVFATSGKECIRIW--SSGRKQELLRIMVYNFNcaCVRFTHDGTSIVS 426
Cdd:cd00200 159 IKLWDLRTGKCVatltgHTGEVNSVAFSPDGEKLLSSSSDGTIKLWdlSTGKCLGTLRGHENGVN--SVAFSPDGYLLAS 236

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 24659653 427 VWNDGIIRAFTPITGRLIYAIPnAHNKGCSALAVASSGRLIVTGGIEGQVRVWK 480
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-395 7.81e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 7.81e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  59 GHTNTISCLDLSKSGKYMASGqinhmGFRGYVIIWNYDQRKEIARHDLHKVSVQAICFTAQDRCVVSIGgvDDGSVIVFD 138
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLATG-----SGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGS--SDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 139 MEAFSPIcqtpasRAISGNA---LTVRPLHNNPYFFVTAGDRHLRLWSIlREEKKLYVqdvlMASKTRVFYCARINKTDE 215
Cdd:cd00200  80 LETGECV------RTLTGHTsyvSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTT----LRGHTDWVNSVAFSPDGT 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 216 FAYlgtgtgdivkivlnCCDRDHVSKQ---GSTSCIlGAFGTHNprkptgrdcnRYVNGVRALYvlEGGRLLIGAGNGDI 292
Cdd:cd00200 149 FVA--------------SSSQDGTIKLwdlRTGKCV-ATLTGHT----------GEVNSVAFSP--DGEKLLSSSSDGTI 201

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653 293 ELVEertdvplinfrdypgptwpyLRTLKKTHV----SGRISSFVRSKTDMFYI-CTDTNEIYGLNIKTWVLKLLRTCHT 367
Cdd:cd00200 202 KLWD--------------------LSTGKCLGTlrghENGVNSVAFSPDGYLLAsGSEDGTIRVWDLRTGECVQTLSGHT 261

                       330       340
                ....*....|....*....|....*...
gi 24659653 368 KSVYCITFPKNYSGVFATSGKECIRIWS 395
Cdd:cd00200 262 NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-184 3.96e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 3.96e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  58 AGHTNTISCLDLSKSGKYMASGqinhmGFRGYVIIWNYDQRKEIARHDLHKVSVQAICFTAQDRCVVSigGVDDGSVIVF 137
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS--SSQDGTIKLW 162

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24659653 138 DMEAFSPIcqtpasRAISG---NALTVRPLHNNPYFFVTAGDRHLRLWSI 184
Cdd:cd00200 163 DLRTGKCV------ATLTGhtgEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
58-184 1.65e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 1.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  58 AGHTNTISCLDLSKSGKYMASGqinhmGFRGYVIIWNYDQRKEIARHDLHKVSVQAICFTAQDRCVVSigGVDDGSVIVF 137
Cdd:COG2319 285 TGHSGGVNSVAFSPDGKLLASG-----SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS--GSDDGTVRLW 357

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24659653 138 DMEAFSPIcqtpasRAISGNALTVRPL---HNNPYFFVTAGDRHLRLWSI 184
Cdd:COG2319 358 DLATGELL------RTLTGHTGAVTSVafsPDGRTLASGSADGTVRLWDL 401
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 449-651 1.58e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.54  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  449 NAHNKGCsALAVASSGRLIVTGGIEGQVRVWKIDPYRQDLvgvlKDHSGPITSLDI----------NYLDTEVISACTDG 518
Cdd:PLN00181 481 NSSNLVC-AIGFDRDGEFFATAGVNKKIKIFECESIIKDG----RDIHYPVVELASrsklsgicwnSYIKSQVASSNFEG 555

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24659653  519 SCVIWDIkrmTRKQVVTA----NTQFMSASYFPTGVQVITCGSD-GRIIYWMVYNGALIRelTASKKSSVNCLAI-NETG 592
Cdd:PLN00181 556 VVQVWDV---ARSQLVTEmkehEKRVWSIDYSSADPTLLASGSDdGSVKLWSINQGVSIG--TIKTKANICCVQFpSESG 630

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24659653  593 DYFITVGSDLQVKLWDYNSGAV---VGIGseHASSVISCAYSPCMTMfVTGSTDGSLIIWDV 651
Cdd:PLN00181 631 RSLAFGSADHKVYYYDLRNPKLplcTMIG--HSKTVSYVRFVDSSTL-VSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 611-650 3.85e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 3.85e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24659653    611 SGAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWD 650
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 488-524 2.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 2.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24659653    488 LVGVLKDHSGPITSLDINYLDTEVISACTDGSCVIWD 524
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
612-650 5.89e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24659653   612 GAVVGIGSEHASSVISCAYSPCMTMFVTGSTDGSLIIWD 650
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
488-524 5.95e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.95e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 24659653   488 LVGVLKDHSGPITSLDINYLDTEVISACTDGSCVIWD 524
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 568-608 2.47e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 2.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 24659653    568 NGALIRELTASKkSSVNCLAINETGDYFITVGSDLQVKLWD 608
Cdd:smart00320   1 SGELLKTLKGHT-GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 621-654 2.74e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 2.74e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 24659653 621 HASSVISCAYSPCMTMFVTGSTDGSLIIWDVPRD 654
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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