NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21426885|ref|NP_619602|]
View 

protocadherin alpha-9 precursor [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 11175747)

protocadherin is a transmembrane protein belonging to the cadherin superfamily and may be a calcium-dependent cell-adhesion protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 829-945 1.18e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 230.29  E-value: 1.18e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   829 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 907
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 21426885   908 SGPGELPDKFIIPGSPAIISIRQEPANNQiDKSDFITF 945
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 60-141 2.86e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 131.50  E-value: 2.86e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    60 QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVVSKDRGDLLEVNLQNGILFVNSRIDREELCGQNAECSIHLEVI 139
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 21426885   140 VD 141
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 276-376 7.68e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 7.68e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 276 VYEVKMYENQENKTLVIWLNATDSDEGINKEVEYSFSSLASSiirQKFLINEKTGEIKINGAIDFEESNNYEIHVDATDK 355
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 21426885 356 GYPPMVAHCTVLVEILDENDN 376
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 489-591 2.59e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 2.59e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 489 EYTVFVKENNPPGVHIFTVLAVDADAQENALVSYSLVERRVgerllSSYVSVHAESGKVFALQPLDHEELELLQFQVSAR 568
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 21426885 569 DAGVPALGSNVTLQVFVQDENDN 591
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 384-481 9.79e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 9.79e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 384 SLSLPVKEDAPLGSVIALISVSDKDSGVNGQVTCSLTNHVPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDGGSP 463
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 21426885 464 SLWATASVSVEVADVNDN 481
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 167-268 3.30e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 3.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 167 EQKILVAESRLLDSRFPLEGASDADVGENSMLTYKLSS-NEFFILDIVNKRGkgkfpVLVLRKLIDREENPQLKLLLTAT 245
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTG-----EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 21426885 246 DGGKPEFTGSVSLLIQVLDVNDN 268
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 611-699 7.36e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 7.36e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 611 VSRSVGAGHVVSKVRAVDADSGYNAWLSYELHPTvGARSPFRVGLYTGEISMTRALDESDLPRQRLLVLVKDHGEPMLIA 690
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG-NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSS 84


                ....*....
gi 21426885 691 TATVLVSLV 699
Cdd:cd11304  85 TATVTITVL 93
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 829-945 1.18e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 230.29  E-value: 1.18e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   829 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 907
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 21426885   908 SGPGELPDKFIIPGSPAIISIRQEPANNQiDKSDFITF 945
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 60-141 2.86e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 131.50  E-value: 2.86e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    60 QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVVSKDRGDLLEVNLQNGILFVNSRIDREELCGQNAECSIHLEVI 139
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 21426885   140 VD 141
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 276-376 7.68e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 7.68e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 276 VYEVKMYENQENKTLVIWLNATDSDEGINKEVEYSFSSLASSiirQKFLINEKTGEIKINGAIDFEESNNYEIHVDATDK 355
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 21426885 356 GYPPMVAHCTVLVEILDENDN 376
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 489-591 2.59e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 2.59e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 489 EYTVFVKENNPPGVHIFTVLAVDADAQENALVSYSLVERRVgerllSSYVSVHAESGKVFALQPLDHEELELLQFQVSAR 568
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 21426885 569 DAGVPALGSNVTLQVFVQDENDN 591
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 384-481 9.79e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 9.79e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 384 SLSLPVKEDAPLGSVIALISVSDKDSGVNGQVTCSLTNHVPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDGGSP 463
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 21426885 464 SLWATASVSVEVADVNDN 481
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 295-378 5.71e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 5.71e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    295 NATDSDEGINKEVEYSfssLASSIIRQKFLINEKTGEIKINGAIDFEESNNYEIHVDATDKGYPPMVAHCTVLVEILDEN 374
Cdd:smart00112   1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 21426885    375 DNAP 378
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 509-593 7.61e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 7.61e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    509 AVDADAQENALVSYSLVERRVGerllsSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVQDE 588
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 21426885    589 NDNPP 593
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 403-483 2.01e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 2.01e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    403 SVSDKDSGVNGQVTCSLTNHVPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDGGSPSLWATASVSVEVADVNDNA 482
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 21426885    483 P 483
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 167-268 3.30e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 3.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 167 EQKILVAESRLLDSRFPLEGASDADVGENSMLTYKLSS-NEFFILDIVNKRGkgkfpVLVLRKLIDREENPQLKLLLTAT 245
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTG-----EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 21426885 246 DGGKPEFTGSVSLLIQVLDVNDN 268
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 187-270 1.03e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.03e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    187 ASDADVGENSMLTYKLSSNEFFILDIVNKRGKgkfpVLVLRKLIDREENPQLKLLLTATDGGKPEFTGSVSLLIQVLDVN 266
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 21426885    267 DNAP 270
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 611-699 7.36e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 7.36e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 611 VSRSVGAGHVVSKVRAVDADSGYNAWLSYELHPTvGARSPFRVGLYTGEISMTRALDESDLPRQRLLVLVKDHGEPMLIA 690
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG-NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSS 84


                ....*....
gi 21426885 691 TATVLVSLV 699
Cdd:cd11304  85 TATVTITVL 93
Cadherin pfam00028
Cadherin domain;
277-371 8.56e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 8.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   277 YEVKMYENQENKTLVIWLNATDSDEGINKEVEYSFSSlasSIIRQKFLINEKTGEIKINGAIDFEESNNYEIHVDATDKG 356
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 21426885   357 YPPMVAHCTVLVEIL 371
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
490-586 2.87e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   490 YTVFVKENNPPGVHIFTVLAVDADAQENALVSYSLVERRVGERLlssyvSVHAESGKVFALQPLDHEELELLQFQVSARD 569
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNF-----RIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 21426885   570 AGVPALGSNVTLQVFVQ 586
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
389-475 3.06e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 3.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   389 VKEDAPLGSVIALISVSDKDSGVNGQVTCSLTNHVPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDGGSPSLWAT 468
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 21426885   469 ASVSVEV 475
Cdd:pfam00028  85 ATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-159 2.79e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.87  E-value: 2.79e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885  62 HYSVPEEAKHGTFVGRI-AQDLGLELAELVprLFRVVSKDRGDLLEVNLQNGILFVNSRIDREELcgqnaeCSIHLEVIV 140
Cdd:cd11304   3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 21426885 141 -DRPLQVF----HVEVEVRDINDN 159
Cdd:cd11304  75 tDGGGPPLsstaTVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 625-699 4.80e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.37  E-value: 4.80e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21426885    625 RAVDADSGYNAWLSYELHPTvGARSPFRVGLYTGEISMTRALDESDLPRQRLLVLVKDHGEPMLIATATVLVSLV 699
Cdd:smart00112   1 SATDADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
618-698 4.99e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.23  E-value: 4.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   618 GHVVSKVRAVDADSGYNAWLSYELHPTvGARSPFRVGLYTGEISMTRALDESDLPRQRLLVLVKDHGEPMLIATATVLVS 697
Cdd:pfam00028  12 GTEVLTVTATDPDLGPNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTIT 90


                  .
gi 21426885   698 L 698
Cdd:pfam00028  91 V 91
Cadherin pfam00028
Cadherin domain;
186-263 7.37e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 7.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   186 GASDADVGENSMLTYKLSSNE---FFILDIVNkrgkgkfPVLVLRKLIDREENPQLKLLLTATDGGKPEFTGSVSLLIQV 262
Cdd:pfam00028  19 TATDPDLGPNGRIFYSILGGGpggNFRIDPDT-------GDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                  .
gi 21426885   263 L 263
Cdd:pfam00028  92 L 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 94-161 3.19e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.80  E-value: 3.19e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21426885     94 FRVVSKDRGDLLEVNLQNGILFVNSRIDREELCgqnaecSIHLEVIV----DRPLQVF-HVEVEVRDINDNPP 161
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 829-945 1.18e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 230.29  E-value: 1.18e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   829 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 907
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 21426885   908 SGPGELPDKFIIPGSPAIISIRQEPANNQiDKSDFITF 945
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 60-141 2.86e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 131.50  E-value: 2.86e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    60 QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVVSKDRGDLLEVNLQNGILFVNSRIDREELCGQNAECSIHLEVI 139
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 21426885   140 VD 141
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 276-376 7.68e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 7.68e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 276 VYEVKMYENQENKTLVIWLNATDSDEGINKEVEYSFSSLASSiirQKFLINEKTGEIKINGAIDFEESNNYEIHVDATDK 355
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 21426885 356 GYPPMVAHCTVLVEILDENDN 376
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 489-591 2.59e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 2.59e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 489 EYTVFVKENNPPGVHIFTVLAVDADAQENALVSYSLVERRVgerllSSYVSVHAESGKVFALQPLDHEELELLQFQVSAR 568
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 21426885 569 DAGVPALGSNVTLQVFVQDENDN 591
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 384-481 9.79e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 9.79e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 384 SLSLPVKEDAPLGSVIALISVSDKDSGVNGQVTCSLTNHVPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDGGSP 463
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 21426885 464 SLWATASVSVEVADVNDN 481
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 295-378 5.71e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 5.71e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    295 NATDSDEGINKEVEYSfssLASSIIRQKFLINEKTGEIKINGAIDFEESNNYEIHVDATDKGYPPMVAHCTVLVEILDEN 374
Cdd:smart00112   1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 21426885    375 DNAP 378
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 509-593 7.61e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 7.61e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    509 AVDADAQENALVSYSLVERRVGerllsSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVQDE 588
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 21426885    589 NDNPP 593
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 403-483 2.01e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 2.01e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    403 SVSDKDSGVNGQVTCSLTNHVPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDGGSPSLWATASVSVEVADVNDNA 482
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 21426885    483 P 483
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 167-268 3.30e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 3.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 167 EQKILVAESRLLDSRFPLEGASDADVGENSMLTYKLSS-NEFFILDIVNKRGkgkfpVLVLRKLIDREENPQLKLLLTAT 245
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTG-----EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 21426885 246 DGGKPEFTGSVSLLIQVLDVNDN 268
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 187-270 1.03e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.03e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    187 ASDADVGENSMLTYKLSSNEFFILDIVNKRGKgkfpVLVLRKLIDREENPQLKLLLTATDGGKPEFTGSVSLLIQVLDVN 266
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 21426885    267 DNAP 270
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 611-699 7.36e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 7.36e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 611 VSRSVGAGHVVSKVRAVDADSGYNAWLSYELHPTvGARSPFRVGLYTGEISMTRALDESDLPRQRLLVLVKDHGEPMLIA 690
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG-NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSS 84


                ....*....
gi 21426885 691 TATVLVSLV 699
Cdd:cd11304  85 TATVTITVL 93
Cadherin pfam00028
Cadherin domain;
277-371 8.56e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 8.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   277 YEVKMYENQENKTLVIWLNATDSDEGINKEVEYSFSSlasSIIRQKFLINEKTGEIKINGAIDFEESNNYEIHVDATDKG 356
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 21426885   357 YPPMVAHCTVLVEIL 371
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
490-586 2.87e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   490 YTVFVKENNPPGVHIFTVLAVDADAQENALVSYSLVERRVGERLlssyvSVHAESGKVFALQPLDHEELELLQFQVSARD 569
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNF-----RIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 21426885   570 AGVPALGSNVTLQVFVQ 586
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
389-475 3.06e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 3.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   389 VKEDAPLGSVIALISVSDKDSGVNGQVTCSLTNHVPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDGGSPSLWAT 468
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 21426885   469 ASVSVEV 475
Cdd:pfam00028  85 ATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-159 2.79e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.87  E-value: 2.79e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885  62 HYSVPEEAKHGTFVGRI-AQDLGLELAELVprLFRVVSKDRGDLLEVNLQNGILFVNSRIDREELcgqnaeCSIHLEVIV 140
Cdd:cd11304   3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 21426885 141 -DRPLQVF----HVEVEVRDINDN 159
Cdd:cd11304  75 tDGGGPPLsstaTVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 625-699 4.80e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.37  E-value: 4.80e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21426885    625 RAVDADSGYNAWLSYELHPTvGARSPFRVGLYTGEISMTRALDESDLPRQRLLVLVKDHGEPMLIATATVLVSLV 699
Cdd:smart00112   1 SATDADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
618-698 4.99e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.23  E-value: 4.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   618 GHVVSKVRAVDADSGYNAWLSYELHPTvGARSPFRVGLYTGEISMTRALDESDLPRQRLLVLVKDHGEPMLIATATVLVS 697
Cdd:pfam00028  12 GTEVLTVTATDPDLGPNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTIT 90


                  .
gi 21426885   698 L 698
Cdd:pfam00028  91 V 91
Cadherin pfam00028
Cadherin domain;
186-263 7.37e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 7.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885   186 GASDADVGENSMLTYKLSSNE---FFILDIVNkrgkgkfPVLVLRKLIDREENPQLKLLLTATDGGKPEFTGSVSLLIQV 262
Cdd:pfam00028  19 TATDPDLGPNGRIFYSILGGGpggNFRIDPDT-------GDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                  .
gi 21426885   263 L 263
Cdd:pfam00028  92 L 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 94-161 3.19e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.80  E-value: 3.19e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21426885     94 FRVVSKDRGDLLEVNLQNGILFVNSRIDREELCgqnaecSIHLEVIV----DRPLQVF-HVEVEVRDINDNPP 161
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
62-172 1.98e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.21  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885    62 HYSVPEEAKHGTFVGRI-AQDLGLELAELVprLFRVVSKDRGDLLEVNLQNGILFVNSRIDREElcgqnaecsihleviv 140
Cdd:pfam00028   2 SASVPENAPVGTEVLTVtATDPDLGPNGRI--FYSILGGGPGGNFRIDPDTGDISTTKPLDRES---------------- 63

                          90       100       110
                  ....*....|....*....|....*....|..
gi 21426885   141 drpLQVFHVEVEVRDiNDNPPIFSVAEQKILV 172
Cdd:pfam00028  64 ---IGEYELTVEATD-SGGPPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 63-159 3.40e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.49  E-value: 3.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885  63 YSVPEEAKHGTFVGRIAQDLGlelaELVPRLFRVVSKDR---GDLLEVNLQNGILFVNSRIDREELcgqnaeCSIHLEVI 139
Cdd:cd00031   4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKealPSWLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                        90       100
                ....*....|....*....|....*
gi 21426885 140 VDR-----PLQVFHVEVEVRDINDN 159
Cdd:cd00031  74 AASlganvPQTSSVFSIEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 488-591 1.36e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 38.86  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21426885 488 PEYTVFVKENNPPgvhifTVLAVDADAQENALVSYSLVERrvGERLLSSYVSVHAESGKVFALQPLDHEELELLQFQVSA 567
Cdd:cd00031   2 PDGSAVEGRSRGS-----FRVSIPTDLIASSGEIIKISAA--GKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSA 74

                        90       100
                ....*....|....*....|....
gi 21426885 568 RDAGVPALGSNVTLQVFVQDENDN 591
Cdd:cd00031  75 ASLGANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH