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Conserved domains on  [gi|19921904|ref|NP_610478|]
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DNA fragmentation factor-related protein 2, isoform A [Drosophila melanogaster]

Protein Classification

CIDE_N domain-containing protein( domain architecture ID 11261923)

CIDE_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAD smart00266
Domains present in proteins implicated in post-mortem DNA fragmentation;
10-84 1.18e-32

Domains present in proteins implicated in post-mortem DNA fragmentation;


:

Pssm-ID: 128562  Cd Length: 74  Bit Score: 118.97  E-value: 1.18e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19921904     10 RPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLGVPASePVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERW 84
Cdd:smart00266   1 RPFKVRDHDRNVRKGVAASSLEELLSKVCDKLALPDS-PVTLVLEEDGTIVDDEEYFQTLPDNTELMALEKGEKW 74
 
Name Accession Description Interval E-value
CAD smart00266
Domains present in proteins implicated in post-mortem DNA fragmentation;
10-84 1.18e-32

Domains present in proteins implicated in post-mortem DNA fragmentation;


Pssm-ID: 128562  Cd Length: 74  Bit Score: 118.97  E-value: 1.18e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19921904     10 RPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLGVPASePVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERW 84
Cdd:smart00266   1 RPFKVRDHDRNVRKGVAASSLEELLSKVCDKLALPDS-PVTLVLEEDGTIVDDEEYFQTLPDNTELMALEKGEKW 74
CIDE_N cd01615
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) ...
 9-86 2.64e-31

CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein.


Pssm-ID: 119367  Cd Length: 78  Bit Score: 115.33  E-value: 2.64e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19921904   9 KRPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLGVPaSEPVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERWYP 86
Cdd:cd01615   2 LRPFKVCDSDRSRKKGVAASSLEELLSKACEKLKLP-SAPVTLVLEEDGTEVDDEEYFQTLPDNTVLMLLEPGQKWTP 78
CIDE-N pfam02017
CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. ...
 10-85 5.60e-30

CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.


Pssm-ID: 460413  Cd Length: 75  Bit Score: 111.44  E-value: 5.60e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19921904    10 RPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLGVPaSEPVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERWY 85
Cdd:pfam02017   1 KPFKVCNVDRSRKKGVAASSLEELLQKGCEKLLLP-SEPVTLVLEEDGTEVDDEEYFQTLPDNTELMLLEKGEKWT 75
 
Name Accession Description Interval E-value
CAD smart00266
Domains present in proteins implicated in post-mortem DNA fragmentation;
10-84 1.18e-32

Domains present in proteins implicated in post-mortem DNA fragmentation;


Pssm-ID: 128562  Cd Length: 74  Bit Score: 118.97  E-value: 1.18e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19921904     10 RPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLGVPASePVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERW 84
Cdd:smart00266   1 RPFKVRDHDRNVRKGVAASSLEELLSKVCDKLALPDS-PVTLVLEEDGTIVDDEEYFQTLPDNTELMALEKGEKW 74
CIDE_N cd01615
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) ...
 9-86 2.64e-31

CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein.


Pssm-ID: 119367  Cd Length: 78  Bit Score: 115.33  E-value: 2.64e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19921904   9 KRPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLGVPaSEPVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERWYP 86
Cdd:cd01615   2 LRPFKVCDSDRSRKKGVAASSLEELLSKACEKLKLP-SAPVTLVLEEDGTEVDDEEYFQTLPDNTVLMLLEPGQKWTP 78
CIDE-N pfam02017
CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. ...
 10-85 5.60e-30

CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.


Pssm-ID: 460413  Cd Length: 75  Bit Score: 111.44  E-value: 5.60e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19921904    10 RPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLGVPaSEPVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERWY 85
Cdd:pfam02017   1 KPFKVCNVDRSRKKGVAASSLEELLQKGCEKLLLP-SEPVTLVLEEDGTEVDDEEYFQTLPDNTELMLLEKGEKWT 75
CIDE_N_FSP27 cd06538
CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, ...
 10-87 7.30e-15

CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, N-terminal) domain is found in the FSP27/CIDE-C protein, which has been identified as a n adipocyte lipid droplet protein that negatively regulates lipolysis and promotes triglyceride accumulation. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. The CIDE-N domain of FSP27 is sufficient to increase apoptosis in vitro when overexpressed.


Pssm-ID: 119371  Cd Length: 79  Bit Score: 69.46  E-value: 7.30e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19921904  10 RPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLGVpaSEPVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERWYPT 87
Cdd:cd06538   3 RPFRVSNADRSLRKGIMADSLEDLLNKVLDALLL--DCISSLVLDEDGTGVDTEEFFQALADNTVFMVLGKGQKWKPP 78
CIDE_N_A cd06539
CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, ...
 10-86 2.68e-14

CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45, and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, the CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance.


Pssm-ID: 119372  Cd Length: 78  Bit Score: 68.05  E-value: 2.68e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19921904  10 RPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLgVPASEPVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERWYP 86
Cdd:cd06539   3 RPFRVSNHDRSSRRGVMASSLQELISKTLDAL-VITSGLVTLVLEEDGTVVDTEEFFQTLGDNTHFMVLEKGQKWTP 78
CIDE_N_B cd06537
CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, ...
 9-87 2.06e-13

CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45 and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance.


Pssm-ID: 119370  Cd Length: 81  Bit Score: 65.32  E-value: 2.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921904   9 KRPLKIWDSWRNVRKGVVVGTFEELLVRGKDKL---GVpasepVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERWY 85
Cdd:cd06537   2 QRPFRVCDHKRTVRKGLTAASLQELLAKALETLllsGV-----LTLVLEEDGTAVDSEDFFELLEDDTCLMVLEQGQSWS 76


                ..
gi 19921904  86 PT 87
Cdd:cd06537  77 PK 78
CIDE_N_ICAD cd06536
CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) ...
 9-86 1.01e-11

CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD (DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40 and ICAD/DFF45 during apoptosis. In normal cells, DFF exists in the nucleus as a heterodimer composed of CAD/DFF40 as a latent nuclease and its chaperone and inhibitor subunit ICAD/DFF45. Apoptotic activation of caspase-3 results in the cleavage of DFF45/ICAD and release of active DFF40/CAD nuclease.


Pssm-ID: 119369  Cd Length: 80  Bit Score: 60.58  E-value: 1.01e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19921904   9 KRPLKIWDSWRNVRKGVVVGTFEELLVRGKDKLGV-PASEPVRVVLECDGTQIEDGEYFRTLANNTVLLLLRQGERWYP 86
Cdd:cd06536   2 LKPCVVCNVSRQKQHGVAASSLEELRIKACESLGFdSSSAPITLVLAEDGTIVEDEDYFLCLPPNTKFVLLAENEKWAP 80
CIDE_N_CAD cd06535
CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) ...
 10-84 1.38e-08

CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of CAD/DFF40 and ICAD/DFF45 during apoptosis. In normal cells, DFF exists in the nucleus as a heterodimer composed of CAD/DFF40 as a latent nuclease and its chaperone and inhibitor subunit ICAD/DFF45. Apoptotic activation of caspase-3 results in the cleavage of DFF45/ICAD and the release of active DFF40/CAD nuclease.


Pssm-ID: 119368  Cd Length: 77  Bit Score: 51.65  E-value: 1.38e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19921904  10 RPLKIwDSWRNVRK-GVVVGTFEELLVRGKDKLGVPASEpVRVVLECDGTQIEDgEYFRTLANNTVLLLLRQGERW 84
Cdd:cd06535   3 KCVKI-RSLNSAQKyGVAAKNLKELLRKGCRLLQLPCAG-SRLCLYEDGTEVTE-EYFPTLPDNTELVLLTPGQSW 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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