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Conserved domains on  [gi|24583862|ref|NP_609556|]
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uncharacterized protein Dmel_CG6583 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
QVR pfam17064
Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for ...
 22-125 9.91e-10

Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for homoeostatic regulation of sleep under normal conditions and following sleep deprivation. It is a novel potassium channel subunit that modulates the Shaker potassium channel which regulates the sleep.


:

Pssm-ID: 435716  Cd Length: 85  Bit Score: 52.22  E-value: 9.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583862    22 IRCYQCSSDQDRkghdSCGAYKRFNRTEHISIECNSdeshmpgsFCMKVVQQgprgfiWDGRWRQVIRRCASVSDTGVVG 101
Cdd:pfam17064   1 IKCYSCNSSDDP----GCGDPFPFNSSSIKLVDCDG--------GCVKIKTK------GSGGSTRVTRGCGPELTEDIKD 62

                          90       100
                  ....*....|....*....|....
gi 24583862   102 VCNWGVYENGVYWeECYCSSDSCN 125
Cdd:pfam17064  63 GCSSSSSGGGGTI-TCFCNTDLCN 85
 
Name Accession Description Interval E-value
QVR pfam17064
Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for ...
 22-125 9.91e-10

Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for homoeostatic regulation of sleep under normal conditions and following sleep deprivation. It is a novel potassium channel subunit that modulates the Shaker potassium channel which regulates the sleep.


Pssm-ID: 435716  Cd Length: 85  Bit Score: 52.22  E-value: 9.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583862    22 IRCYQCSSDQDRkghdSCGAYKRFNRTEHISIECNSdeshmpgsFCMKVVQQgprgfiWDGRWRQVIRRCASVSDTGVVG 101
Cdd:pfam17064   1 IKCYSCNSSDDP----GCGDPFPFNSSSIKLVDCDG--------GCVKIKTK------GSGGSTRVTRGCGPELTEDIKD 62

                          90       100
                  ....*....|....*....|....
gi 24583862   102 VCNWGVYENGVYWeECYCSSDSCN 125
Cdd:pfam17064  63 GCSSSSSGGGGTI-TCFCNTDLCN 85
TFP_LU_ECD_Twit cd23593
extracellular domain (ECD) found in Drosophila melanogaster Target of wit (Twit) and similar ...
 21-127 2.95e-08

extracellular domain (ECD) found in Drosophila melanogaster Target of wit (Twit) and similar proteins; Twit is a GPI-anchored membrane ligand of the Ly6 family that participates in retrograde signalling as a downstream target of the bone morphogenetic protein (BMP) pathway receptor encoded by Wishful thinking (Wit). It acts in neurons, regulating spontaneous neurotransmitter release during the maturation of larval neuromuscular junctions. Twit contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467122  Cd Length: 101  Bit Score: 48.56  E-value: 2.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583862  21 AIRCYQCSSDQDRKGHDScgaykrFNRTEHISI--ECNSDESHMPGS----FCMKVVQQGprgfiwDGRWrQVIRRCASV 94
Cdd:cd23593   1 ALRCWSCSSDTDPFCGDP------FNTTENHFHltDCDRTASPSYYLnerpVCRKIVQRV------NGEL-VVIRSCAWE 67

                        90       100       110
                ....*....|....*....|....*....|....
gi 24583862  95 SDTGVVGVCNWGVYENGVYWEEC-YCSSDSCNGS 127
Cdd:cd23593  68 NEDDVDGPCSNTSTGSYIKIESCeTCSTDGCNSA 101
 
Name Accession Description Interval E-value
QVR pfam17064
Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for ...
 22-125 9.91e-10

Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for homoeostatic regulation of sleep under normal conditions and following sleep deprivation. It is a novel potassium channel subunit that modulates the Shaker potassium channel which regulates the sleep.


Pssm-ID: 435716  Cd Length: 85  Bit Score: 52.22  E-value: 9.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583862    22 IRCYQCSSDQDRkghdSCGAYKRFNRTEHISIECNSdeshmpgsFCMKVVQQgprgfiWDGRWRQVIRRCASVSDTGVVG 101
Cdd:pfam17064   1 IKCYSCNSSDDP----GCGDPFPFNSSSIKLVDCDG--------GCVKIKTK------GSGGSTRVTRGCGPELTEDIKD 62

                          90       100
                  ....*....|....*....|....
gi 24583862   102 VCNWGVYENGVYWeECYCSSDSCN 125
Cdd:pfam17064  63 GCSSSSSGGGGTI-TCFCNTDLCN 85
TFP_LU_ECD_Twit cd23593
extracellular domain (ECD) found in Drosophila melanogaster Target of wit (Twit) and similar ...
 21-127 2.95e-08

extracellular domain (ECD) found in Drosophila melanogaster Target of wit (Twit) and similar proteins; Twit is a GPI-anchored membrane ligand of the Ly6 family that participates in retrograde signalling as a downstream target of the bone morphogenetic protein (BMP) pathway receptor encoded by Wishful thinking (Wit). It acts in neurons, regulating spontaneous neurotransmitter release during the maturation of larval neuromuscular junctions. Twit contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467122  Cd Length: 101  Bit Score: 48.56  E-value: 2.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583862  21 AIRCYQCSSDQDRKGHDScgaykrFNRTEHISI--ECNSDESHMPGS----FCMKVVQQGprgfiwDGRWrQVIRRCASV 94
Cdd:cd23593   1 ALRCWSCSSDTDPFCGDP------FNTTENHFHltDCDRTASPSYYLnerpVCRKIVQRV------NGEL-VVIRSCAWE 67

                        90       100       110
                ....*....|....*....|....*....|....
gi 24583862  95 SDTGVVGVCNWGVYENGVYWEEC-YCSSDSCNGS 127
Cdd:cd23593  68 NEDDVDGPCSNTSTGSYIKIESCeTCSTDGCNSA 101
TFP_LU_ECD_Crok cd23592
extracellular domain (ECD), Ly6/uPAR superfamily, three finger domain (TFD) fold, found in ...
 21-127 4.43e-05

extracellular domain (ECD), Ly6/uPAR superfamily, three finger domain (TFD) fold, found in Drosophila melanogaster protein crooked and similar proteins; Crooked (Crok) is a glycosylphosphatidylinositol (GPI)-anchored protein that plays an essential role in septa formation, the membrane accumulation of SJ components and paracellular barrier functions. It required for septate junction (SJ) formation and function in a tissue-autonomous manner. Crooked is specifically required for correct membrane trafficking of Neurexin IV, a central SJ component. Crooked is a member of the Drosophila Ly6 superfamily. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467121  Cd Length: 104  Bit Score: 40.17  E-value: 4.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583862  21 AIRCYQCSSDQDRKghdsCGAYkrFNRTEHISIECNSD--ESHMPGS---FCMKVVQQGprgfiwDGRWRqVIRRCASVS 95
Cdd:cd23592   2 AIKCWVCRSDYDPR----CGDP--FDNLTLPITDCNQEkkPHHLPGVkatMCRKMRQKV------NGEWR-YIRSCAFLG 68

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 24583862  96 DTGVVGVCNW---GVYENGVYWEECYCSS-DSCNGS 127
Cdd:cd23592  69 EPGIGGDERWcleRSGTYNIHIEDCTCNSkDGCNAA 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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