|
Name |
Accession |
Description |
Interval |
E-value |
| Beach |
cd06071 |
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ... |
345-588 |
4.17e-88 |
|
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
:
Pssm-ID: 100117 [Multi-domain] Cd Length: 275 Bit Score: 288.76 E-value: 4.17e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 345 TEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWVTDFSGR------GGGAWRDLTKSKYRLNKGDVHLDLMYAHAS 418
Cdd:cd06071 1 TKKWQNGEISNFEYLMYLNTLAGRSFNDLSQYPIFPWVISDYTSeeldlnDPSTYRDLSKPIGALNKERLQLLKERYESD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 419 QHGSADGSYqaigdqAPHHVSDFLSEITYFVYMARRTP--QSILCAHVR-PIWVPAEYPVSIQRLQE--WTPDECIPEFY 493
Cdd:cd06071 81 SDDSDPPFH------YGSHYSNPAIVLYYLVRLEPFTTlhLSLQGGHFDaADRLFNSIPSSWRSASEnpSDVKELIPEFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 494 SDPMIFKSIHED---------LPDLELPAWATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLT 564
Cdd:cd06071 155 YLPEFFLNINKFdfgkqdgekVNDVELPPWAKSPEEFIRKHREALESEYVSKNLHHWIDLIFGYKQRGEEAVKAKNVFHP 234
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 24583787 565 LVDQ-----------------HRNLSQRGIVQLFASAHPPR 588
Cdd:cd06071 235 LTYEgsvdldsidvereaieaQINNFGQTPVQLFTKPHPKR 275
|
|
| WD40 super family |
cl29593 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1651-1876 |
7.34e-27 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
The actual alignment was detected with superfamily member cd00200:
Pssm-ID: 475233 [Multi-domain] Cd Length: 289 Bit Score: 112.81 E-value: 7.34e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1651 LQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLrsegdgrKTSACQFTYTAHKKSINSLGFLESLRYVVSC--DSG 1728
Cdd:cd00200 44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-------ETGECVRTLTGHTSYVSSVAFSPDGRILSSSsrDKT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1729 IHLWDPFIGRPLSVLDAprHSA-VTVVKCLPShSPLVIAGTAESTVKMVDARSCEyvnewrvCNASLP--NATVRCLAVA 1805
Cdd:cd00200 117 IKVWDVETGKCLTTLRG--HTDwVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGK-------CVATLTghTGEVNSVAFS 186
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24583787 1806 PSGNWLAAGLSSGCIVQLDTRTGMVINSWRPMECDLLQLA-APSDQFLVSSALDHSLAVWHALDGIMHYQLK 1876
Cdd:cd00200 187 PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAfSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Beach |
cd06071 |
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ... |
345-588 |
4.17e-88 |
|
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
Pssm-ID: 100117 [Multi-domain] Cd Length: 275 Bit Score: 288.76 E-value: 4.17e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 345 TEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWVTDFSGR------GGGAWRDLTKSKYRLNKGDVHLDLMYAHAS 418
Cdd:cd06071 1 TKKWQNGEISNFEYLMYLNTLAGRSFNDLSQYPIFPWVISDYTSeeldlnDPSTYRDLSKPIGALNKERLQLLKERYESD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 419 QHGSADGSYqaigdqAPHHVSDFLSEITYFVYMARRTP--QSILCAHVR-PIWVPAEYPVSIQRLQE--WTPDECIPEFY 493
Cdd:cd06071 81 SDDSDPPFH------YGSHYSNPAIVLYYLVRLEPFTTlhLSLQGGHFDaADRLFNSIPSSWRSASEnpSDVKELIPEFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 494 SDPMIFKSIHED---------LPDLELPAWATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLT 564
Cdd:cd06071 155 YLPEFFLNINKFdfgkqdgekVNDVELPPWAKSPEEFIRKHREALESEYVSKNLHHWIDLIFGYKQRGEEAVKAKNVFHP 234
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 24583787 565 LVDQ-----------------HRNLSQRGIVQLFASAHPPR 588
Cdd:cd06071 235 LTYEgsvdldsidvereaieaQINNFGQTPVQLFTKPHPKR 275
|
|
| Beach |
smart01026 |
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the ... |
345-588 |
5.33e-80 |
|
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein. The BEACH domain is usually followed by a series of WD repeats. The function of the BEACH domain is unknown.
Pssm-ID: 214982 Cd Length: 280 Bit Score: 265.63 E-value: 5.33e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 345 TEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWVT--------DFSGRGGgaWRDLTKsKYRLnKGDVHLDLMYAH 416
Cdd:smart01026 1 TQKWQNGEISNFEYLMHLNTLAGRSYNDLTQYPVFPWVLadytsetlDLSNPST--FRDLSK-PIGA-LNPERLEFFYER 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 417 ASQHGSADgsyqaigdQAPHHV-SDFLSEITYFVYMARRTP---------------QSILCAHVRPIWVPAeYPVSIQRL 480
Cdd:smart01026 77 YEELEDPD--------IPPFHYgTHYSSAGIVLYYLIRLEPfttlflqlqggrfdhADRLFHSVAATWRSA-SLESMTDV 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 481 QEwtpdeCIPEFYSDPMIFKSIH----------EDLPDLELPAWA-TCPEDFICKHREALESQYVSERLHHWIDLNFGYK 549
Cdd:smart01026 148 KE-----LIPEFFYLPEFLVNINgfdfgtrqdgEDVDDVELPPWAkGSPEEFIRKHREALESEYVSQHLHHWIDLIFGYK 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 24583787 550 LSGKAAVKSKNVCLTLV--------------------DQHRNLSQRGIvQLFASAHPPR 588
Cdd:smart01026 223 QRGKEAVEALNVFHPLTyegavdldsiedpverkaleGQIHNFGQTPK-QLFKEPHPPR 280
|
|
| Beach |
pfam02138 |
Beige/BEACH domain; |
346-588 |
1.15e-41 |
|
Beige/BEACH domain;
Pssm-ID: 460459 Cd Length: 277 Bit Score: 155.33 E-value: 1.15e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 346 EMWCNGQLSNFDYLTILNNACGRS---LTNaayHHIMPWV-TDFSG-----RGGGAWRDLTK-----SKYRLNKgdvhLD 411
Cdd:pfam02138 1 KKWQNGEISNFEYLMYLNTLAGRSfndLSQ---YPVFPWVlADYTSeeldlNDPSTYRDLSKpigalNEERLEK----FK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 412 LMYAhasqhgsadgsyQAIGDQAPHHVSDFLSEITY-FVYMARRTPQSilcahvrpiwvpaEYPVSIQ--------RL-- 480
Cdd:pfam02138 74 ERYE------------ELEDDDPPFHYGSHYSSPGIvLYYLIRLEPFT-------------TLHIELQggkfdhpdRLfh 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 481 ---QEW------TPD--ECIPEFYSDPMIFKSIH----------EDLPDLELPAWAT-CPEDFICKHREALESQYVSERL 538
Cdd:pfam02138 129 sieEAWrsasnsTSDvkELIPEFFYLPEFLLNSNnfdlggrqdgEKVDDVELPPWAKkSPEEFVRKHREALESDYVSENL 208
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24583787 539 HHWIDLNFGYKLSGKAAVKSKNV--------CLTLVDQHRNLSQRGI-----------VQLFASAHPPR 588
Cdd:pfam02138 209 HEWIDLIFGYKQRGEEAVEALNVfhpltyegSVDLDSIKDPVERDAIeaqiknfgqtpKQLFTKPHPPR 277
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1651-1876 |
7.34e-27 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 112.81 E-value: 7.34e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1651 LQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLrsegdgrKTSACQFTYTAHKKSINSLGFLESLRYVVSC--DSG 1728
Cdd:cd00200 44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-------ETGECVRTLTGHTSYVSSVAFSPDGRILSSSsrDKT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1729 IHLWDPFIGRPLSVLDAprHSA-VTVVKCLPShSPLVIAGTAESTVKMVDARSCEyvnewrvCNASLP--NATVRCLAVA 1805
Cdd:cd00200 117 IKVWDVETGKCLTTLRG--HTDwVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGK-------CVATLTghTGEVNSVAFS 186
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24583787 1806 PSGNWLAAGLSSGCIVQLDTRTGMVINSWRPMECDLLQLA-APSDQFLVSSALDHSLAVWHALDGIMHYQLK 1876
Cdd:cd00200 187 PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAfSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1642-1951 |
7.93e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 97.29 E-value: 7.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1642 QTLNLKQIRLQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLrsegdgrKTSACQFTYTAHKKSINSLGFLESLRY 1721
Cdd:COG2319 62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-------ATGLLLRTLTGHTGAVRSVAFSPDGKT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1722 VVSC--DSGIHLWDPFIGRPLSVLDAPRHSAVTVvkclpSHSP---LVIAGTAESTVKMVDARSCEYVNEWRVcnaslPN 1796
Cdd:COG2319 135 LASGsaDGTVRLWDLATGKLLRTLTGHSGAVTSV-----AFSPdgkLLASGSDDGTVRLWDLATGKLLRTLTG-----HT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1797 ATVRCLAVAPSGNWLAAGLSSGCIVQLDTRTGMVINSWRPMECDLLQLA-APSDQFLVSSALDHSLAVWHALDGIMHYQL 1875
Cdd:COG2319 205 GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATGELLRTL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1876 KPPPEPAHflqSV-----GPSLVYATTGNRVGVYaDVAHSHAFSTITklrseTFRGVLTSLAVLPLNRAFLAGNESGNIA 1950
Cdd:COG2319 285 TGHSGGVN---SVafspdGKLLASGSDDGTVRLW-DLATGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVR 355
|
.
gi 24583787 1951 L 1951
Cdd:COG2319 356 L 356
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1651-1686 |
5.81e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.95 E-value: 5.81e-05
10 20 30
....*....|....*....|....*....|....*.
gi 24583787 1651 LQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWS 1686
Cdd:pfam00400 4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1651-1686 |
9.83e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.14 E-value: 9.83e-05
10 20 30
....*....|....*....|....*....|....*.
gi 24583787 1651 LQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWS 1686
Cdd:smart00320 5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Beach |
cd06071 |
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ... |
345-588 |
4.17e-88 |
|
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
Pssm-ID: 100117 [Multi-domain] Cd Length: 275 Bit Score: 288.76 E-value: 4.17e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 345 TEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWVTDFSGR------GGGAWRDLTKSKYRLNKGDVHLDLMYAHAS 418
Cdd:cd06071 1 TKKWQNGEISNFEYLMYLNTLAGRSFNDLSQYPIFPWVISDYTSeeldlnDPSTYRDLSKPIGALNKERLQLLKERYESD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 419 QHGSADGSYqaigdqAPHHVSDFLSEITYFVYMARRTP--QSILCAHVR-PIWVPAEYPVSIQRLQE--WTPDECIPEFY 493
Cdd:cd06071 81 SDDSDPPFH------YGSHYSNPAIVLYYLVRLEPFTTlhLSLQGGHFDaADRLFNSIPSSWRSASEnpSDVKELIPEFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 494 SDPMIFKSIHED---------LPDLELPAWATCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGKAAVKSKNVCLT 564
Cdd:cd06071 155 YLPEFFLNINKFdfgkqdgekVNDVELPPWAKSPEEFIRKHREALESEYVSKNLHHWIDLIFGYKQRGEEAVKAKNVFHP 234
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 24583787 565 LVDQ-----------------HRNLSQRGIVQLFASAHPPR 588
Cdd:cd06071 235 LTYEgsvdldsidvereaieaQINNFGQTPVQLFTKPHPKR 275
|
|
| Beach |
smart01026 |
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the ... |
345-588 |
5.33e-80 |
|
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein. The BEACH domain is usually followed by a series of WD repeats. The function of the BEACH domain is unknown.
Pssm-ID: 214982 Cd Length: 280 Bit Score: 265.63 E-value: 5.33e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 345 TEMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWVT--------DFSGRGGgaWRDLTKsKYRLnKGDVHLDLMYAH 416
Cdd:smart01026 1 TQKWQNGEISNFEYLMHLNTLAGRSYNDLTQYPVFPWVLadytsetlDLSNPST--FRDLSK-PIGA-LNPERLEFFYER 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 417 ASQHGSADgsyqaigdQAPHHV-SDFLSEITYFVYMARRTP---------------QSILCAHVRPIWVPAeYPVSIQRL 480
Cdd:smart01026 77 YEELEDPD--------IPPFHYgTHYSSAGIVLYYLIRLEPfttlflqlqggrfdhADRLFHSVAATWRSA-SLESMTDV 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 481 QEwtpdeCIPEFYSDPMIFKSIH----------EDLPDLELPAWA-TCPEDFICKHREALESQYVSERLHHWIDLNFGYK 549
Cdd:smart01026 148 KE-----LIPEFFYLPEFLVNINgfdfgtrqdgEDVDDVELPPWAkGSPEEFIRKHREALESEYVSQHLHHWIDLIFGYK 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 24583787 550 LSGKAAVKSKNVCLTLV--------------------DQHRNLSQRGIvQLFASAHPPR 588
Cdd:smart01026 223 QRGKEAVEALNVFHPLTyegavdldsiedpverkaleGQIHNFGQTPK-QLFKEPHPPR 280
|
|
| Beach |
pfam02138 |
Beige/BEACH domain; |
346-588 |
1.15e-41 |
|
Beige/BEACH domain;
Pssm-ID: 460459 Cd Length: 277 Bit Score: 155.33 E-value: 1.15e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 346 EMWCNGQLSNFDYLTILNNACGRS---LTNaayHHIMPWV-TDFSG-----RGGGAWRDLTK-----SKYRLNKgdvhLD 411
Cdd:pfam02138 1 KKWQNGEISNFEYLMYLNTLAGRSfndLSQ---YPVFPWVlADYTSeeldlNDPSTYRDLSKpigalNEERLEK----FK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 412 LMYAhasqhgsadgsyQAIGDQAPHHVSDFLSEITY-FVYMARRTPQSilcahvrpiwvpaEYPVSIQ--------RL-- 480
Cdd:pfam02138 74 ERYE------------ELEDDDPPFHYGSHYSSPGIvLYYLIRLEPFT-------------TLHIELQggkfdhpdRLfh 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 481 ---QEW------TPD--ECIPEFYSDPMIFKSIH----------EDLPDLELPAWAT-CPEDFICKHREALESQYVSERL 538
Cdd:pfam02138 129 sieEAWrsasnsTSDvkELIPEFFYLPEFLLNSNnfdlggrqdgEKVDDVELPPWAKkSPEEFVRKHREALESDYVSENL 208
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24583787 539 HHWIDLNFGYKLSGKAAVKSKNV--------CLTLVDQHRNLSQRGI-----------VQLFASAHPPR 588
Cdd:pfam02138 209 HEWIDLIFGYKQRGEEAVEALNVfhpltyegSVDLDSIKDPVERDAIeaqiknfgqtpKQLFTKPHPPR 277
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1651-1876 |
7.34e-27 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 112.81 E-value: 7.34e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1651 LQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLrsegdgrKTSACQFTYTAHKKSINSLGFLESLRYVVSC--DSG 1728
Cdd:cd00200 44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-------ETGECVRTLTGHTSYVSSVAFSPDGRILSSSsrDKT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1729 IHLWDPFIGRPLSVLDAprHSA-VTVVKCLPShSPLVIAGTAESTVKMVDARSCEyvnewrvCNASLP--NATVRCLAVA 1805
Cdd:cd00200 117 IKVWDVETGKCLTTLRG--HTDwVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGK-------CVATLTghTGEVNSVAFS 186
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24583787 1806 PSGNWLAAGLSSGCIVQLDTRTGMVINSWRPMECDLLQLA-APSDQFLVSSALDHSLAVWHALDGIMHYQLK 1876
Cdd:cd00200 187 PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAfSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1642-1951 |
7.93e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 97.29 E-value: 7.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1642 QTLNLKQIRLQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLrsegdgrKTSACQFTYTAHKKSINSLGFLESLRY 1721
Cdd:COG2319 62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-------ATGLLLRTLTGHTGAVRSVAFSPDGKT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1722 VVSC--DSGIHLWDPFIGRPLSVLDAPRHSAVTVvkclpSHSP---LVIAGTAESTVKMVDARSCEYVNEWRVcnaslPN 1796
Cdd:COG2319 135 LASGsaDGTVRLWDLATGKLLRTLTGHSGAVTSV-----AFSPdgkLLASGSDDGTVRLWDLATGKLLRTLTG-----HT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1797 ATVRCLAVAPSGNWLAAGLSSGCIVQLDTRTGMVINSWRPMECDLLQLA-APSDQFLVSSALDHSLAVWHALDGIMHYQL 1875
Cdd:COG2319 205 GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATGELLRTL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1876 KPPPEPAHflqSV-----GPSLVYATTGNRVGVYaDVAHSHAFSTITklrseTFRGVLTSLAVLPLNRAFLAGNESGNIA 1950
Cdd:COG2319 285 TGHSGGVN---SVafspdGKLLASGSDDGTVRLW-DLATGKLLRTLT-----GHTGAVRSVAFSPDGKTLASGSDDGTVR 355
|
.
gi 24583787 1951 L 1951
Cdd:COG2319 356 L 356
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1650-1866 |
1.69e-19 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 93.05 E-value: 1.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1650 RLQSFVGHTNSVRAI-YALDNeNSFISASKDKTVKLWSLRsegdgrkTSACQFTYTAHKKSINSLGFLESLRYVVSC--D 1726
Cdd:COG2319 196 LLRTLTGHTGAVRSVaFSPDG-KLLASGSADGTVRLWDLA-------TGKLLRTLTGHSGSVRSVAFSPDGRLLASGsaD 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1727 SGIHLWDPFIGRPLSVLDAPRHSAVTVVkclpsHSP---LVIAGTAESTVKMVDARSCEYVNEWRVcnaslPNATVRCLA 1803
Cdd:COG2319 268 GTVRLWDLATGELLRTLTGHSGGVNSVA-----FSPdgkLLASGSDDGTVRLWDLATGKLLRTLTG-----HTGAVRSVA 337
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24583787 1804 VAPSGNWLAAGlSSGCIVQL-DTRTGMVINSWRPMECDLLQLA-APSDQFLVSSALDHSLAVWHA 1866
Cdd:COG2319 338 FSPDGKTLASG-SDDGTVRLwDLATGELLRTLTGHTGAVTSVAfSPDGRTLASGSADGTVRLWDL 401
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1651-1869 |
3.51e-19 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 92.28 E-value: 3.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1651 LQSFVGHTNSVRAIyALDNENSFI-SASKDKTVKLWSLRsegdgrkTSACQFTYTAHKKSINSLGFLESLRYVVSC--DS 1727
Cdd:COG2319 155 LRTLTGHSGAVTSV-AFSPDGKLLaSGSDDGTVRLWDLA-------TGKLLRTLTGHTGAVRSVAFSPDGKLLASGsaDG 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1728 GIHLWDPFIGRPLSVLDAPRHSAVTVvkclpSHSP---LVIAGTAESTVKMVDARSCEYVNEWRVcnaslPNATVRCLAV 1804
Cdd:COG2319 227 TVRLWDLATGKLLRTLTGHSGSVRSV-----AFSPdgrLLASGSADGTVRLWDLATGELLRTLTG-----HSGGVNSVAF 296
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24583787 1805 APSGNWLAAGlSSGCIVQL-DTRTGMVINSWRPMECDLLQLA-APSDQFLVSSALDHSLAVWHALDG 1869
Cdd:COG2319 297 SPDGKLLASG-SDDGTVRLwDLATGKLLRTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATG 362
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1651-1820 |
9.63e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 82.77 E-value: 9.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1651 LQSFVGHTNSVRAIyALDNENSFI-SASKDKTVKLWSLRSEGdgrktsaCQFTYTAHKKSINSLGFLESLRYVVSC--DS 1727
Cdd:cd00200 128 LTTLRGHTDWVNSV-AFSPDGTFVaSSSQDGTIKLWDLRTGK-------CVATLTGHTGEVNSVAFSPDGEKLLSSssDG 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1728 GIHLWDPFIGRPLSVLDAPRHSAVTVVKCLPSHspLVIAGTAESTVKMVDARSCEyvnewrvCNASLP--NATVRCLAVA 1805
Cdd:cd00200 200 TIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY--LLASGSEDGTIRVWDLRTGE-------CVQTLSghTNSVTSLAWS 270
|
170
....*....|....*
gi 24583787 1806 PSGNWLAAGLSSGCI 1820
Cdd:cd00200 271 PDGKRLASGSADGTI 285
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1645-1774 |
1.87e-16 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 82.00 E-value: 1.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1645 NLKQIRL-QSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLRsegdgrkTSACQFTYTAHKKSINSLGFLESLRYVV 1723
Cdd:cd00200 163 DLRTGKCvATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS-------TGKCLGTLRGHENGVNSVAFSPDGYLLA 235
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 24583787 1724 SC--DSGIHLWDPFIGRPLSVLDAPRHSaVTVVKCLPShSPLVIAGTAESTVK 1774
Cdd:cd00200 236 SGseDGTIRVWDLRTGECVQTLSGHTNS-VTSLAWSPD-GKRLASGSADGTIR 286
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1650-1780 |
2.37e-09 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 61.85 E-value: 2.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583787 1650 RLQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWSLrsegdgrKTSACQFTYTAHKKSINSLGFLESLRYVVSC--DS 1727
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL-------ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGsdDG 352
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 24583787 1728 GIHLWDPFIGRPLSVLDAPRhSAVTVVKCLPShSPLVIAGTAESTVKMVDARS 1780
Cdd:COG2319 353 TVRLWDLATGELLRTLTGHT-GAVTSVAFSPD-GRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1651-1686 |
5.81e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.95 E-value: 5.81e-05
10 20 30
....*....|....*....|....*....|....*.
gi 24583787 1651 LQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWS 1686
Cdd:pfam00400 4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1651-1686 |
9.83e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.14 E-value: 9.83e-05
10 20 30
....*....|....*....|....*....|....*.
gi 24583787 1651 LQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWS 1686
Cdd:smart00320 5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1651-1686 |
1.31e-03 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 43.09 E-value: 1.31e-03
10 20 30
....*....|....*....|....*....|....*.
gi 24583787 1651 LQSFVGHTNSVRAIYALDNENSFISASKDKTVKLWS 1686
Cdd:cd00200 254 VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1696-1733 |
3.05e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.29 E-value: 3.05e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 24583787 1696 TSACQFTYTAHKKSINSLGFLESLRYVVSC--DSGIHLWD 1733
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGsdDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1699-1733 |
5.91e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.17 E-value: 5.91e-03
10 20 30
....*....|....*....|....*....|....*..
gi 24583787 1699 CQFTYTAHKKSINSLGFLESLRYVVSC--DSGIHLWD 1733
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSPDGKLLASGsdDGTVKVWD 39
|
|
| |
