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Conserved domains on  [gi|24583427|ref|NP_609401|]
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uncharacterized protein Dmel_CG5188 [Drosophila melanogaster]

Protein Classification

methionyl aminopeptidase( domain architecture ID 10099531)

methionyl aminopeptidase catalyzes the hydrolytic removal of N-terminal methionine residues

CATH:  3.90.230.10
EC:  3.4.11.18
Gene Ontology:  GO:0070006|GO:0046872|GO:0006508
PubMed:  7674922

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 79-315 5.28e-125

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


:

Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 357.19  E-value: 5.28e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  79 IDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFPKSICTSINNIACHGIPDDRQLADGD 158
Cdd:cd01086   1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 159 IINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASIAAFIGHG 238
Cdd:cd01086  81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24583427 239 IGSYFHGPPEILHYY-NEIPGKMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITETGTEILTR 315
Cdd:cd01086 161 IGRKFHEEPQIPNYGrPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
 
Name Accession Description Interval E-value
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 79-315 5.28e-125

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 357.19  E-value: 5.28e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  79 IDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFPKSICTSINNIACHGIPDDRQLADGD 158
Cdd:cd01086   1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 159 IINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASIAAFIGHG 238
Cdd:cd01086  81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24583427 239 IGSYFHGPPEILHYY-NEIPGKMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITETGTEILTR 315
Cdd:cd01086 161 IGRKFHEEPQIPNYGrPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
72-315 6.90e-116

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 334.28  E-value: 6.90e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  72 EIKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFPKSICTSINNIACHGIPDD 151
Cdd:COG0024   2 EIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPSD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 152 RQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASI 231
Cdd:COG0024  82 RVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 232 AAFIGHGIGSYFHGPPEILHYYNeiPG---KMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITET 308
Cdd:COG0024 162 REFVGHGIGREMHEEPQVPNYGR--PGrgpRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTED 239


                ....*..
gi 24583427 309 GTEILTR 315
Cdd:COG0024 240 GPEILTL 246
PRK05716 PRK05716
methionine aminopeptidase; Validated
 73-314 1.82e-107

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 313.22  E-value: 1.82e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   73 IKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFPKSICTSINNIACHGIPDDR 152
Cdd:PRK05716   5 IKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIPSDK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  153 QLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASIA 232
Cdd:PRK05716  85 VLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFSVVR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  233 AFIGHGIGSYFHGPPEILHYYNeiPG---KMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITETG 309
Cdd:PRK05716 165 EYCGHGIGRKFHEEPQIPHYGA--PGdgpVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTEDG 242


                 ....*
gi 24583427  310 TEILT 314
Cdd:PRK05716 243 PEILT 247
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 72-314 6.67e-89

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 265.75  E-value: 6.67e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427    72 EIKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFPKSICTSINNIACHGIPDD 151
Cdd:TIGR00500   2 SLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPDK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   152 RQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASI 231
Cdd:TIGR00500  82 KVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   232 AAFIGHGIGSYFHGPPEILHYY-NEIPGKMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITETGT 310
Cdd:TIGR00500 162 REYCGHGIGRKFHEEPQIPNYGkKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNGP 241


                  ....
gi 24583427   311 EILT 314
Cdd:TIGR00500 242 EILT 245
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 80-307 2.30e-50

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 165.88  E-value: 2.30e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427    80 DAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYpsplRYAGFPKSICTSINNIACHGIPDDRQLADGDI 159
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   160 INIDVTV-FLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASIAA-FIGH 237
Cdd:pfam00557  77 VLIDVGAeYDGGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFPhGLGH 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   238 GIGSYFHGPPEILHYYNEipGKMQPGMTFTIEPILSLggaeiavlqdgwtaisLDGARSAQFEHTILITE 307
Cdd:pfam00557 157 GIGLEVHEGPYISRGGDD--RVLEPGMVFTIEPGIYF----------------IPGWGGVRIEDTVLVTE 208
 
Name Accession Description Interval E-value
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 79-315 5.28e-125

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 357.19  E-value: 5.28e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  79 IDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFPKSICTSINNIACHGIPDDRQLADGD 158
Cdd:cd01086   1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 159 IINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASIAAFIGHG 238
Cdd:cd01086  81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24583427 239 IGSYFHGPPEILHYY-NEIPGKMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITETGTEILTR 315
Cdd:cd01086 161 IGRKFHEEPQIPNYGrPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
72-315 6.90e-116

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 334.28  E-value: 6.90e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  72 EIKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFPKSICTSINNIACHGIPDD 151
Cdd:COG0024   2 EIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPSD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 152 RQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASI 231
Cdd:COG0024  82 RVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 232 AAFIGHGIGSYFHGPPEILHYYNeiPG---KMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITET 308
Cdd:COG0024 162 REFVGHGIGREMHEEPQVPNYGR--PGrgpRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTED 239


                ....*..
gi 24583427 309 GTEILTR 315
Cdd:COG0024 240 GPEILTL 246
PRK05716 PRK05716
methionine aminopeptidase; Validated
 73-314 1.82e-107

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 313.22  E-value: 1.82e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   73 IKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFPKSICTSINNIACHGIPDDR 152
Cdd:PRK05716   5 IKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIPSDK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  153 QLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASIA 232
Cdd:PRK05716  85 VLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFSVVR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  233 AFIGHGIGSYFHGPPEILHYYNeiPG---KMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITETG 309
Cdd:PRK05716 165 EYCGHGIGRKFHEEPQIPHYGA--PGdgpVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTEDG 242


                 ....*
gi 24583427  310 TEILT 314
Cdd:PRK05716 243 PEILT 247
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 42-315 1.29e-103

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 308.69  E-value: 1.29e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   42 VSPERFVPEEIKKPAYYFKNMP---PGNTL-GSPEIKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERI 117
Cdd:PLN03158 102 ISPRRVVPDHIPKPDWALDGTPkiePNSDLqHSVEIKTPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVHEAT 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  118 LESKAYPSPLRYAGFPKSICTSINNIACHGIPDDRQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKS 197
Cdd:PLN03158 182 IAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLVKCTYE 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  198 CLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASIAAFIGHGIGSYFHGPPEILHY-YNEIPGKMQPGMTFTIEPILSLGG 276
Cdd:PLN03158 262 CLEKAIAIVKPGVRYREVGEVINRHATMSGLSVVKSYCGHGIGELFHCAPNIPHYaRNKAVGVMKAGQVFTIEPMINAGV 341

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 24583427  277 AEIAVLQDGWTAISLDGARSAQFEHTILITETGTEILTR 315
Cdd:PLN03158 342 WRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLTA 380
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 71-314 2.59e-101

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 297.90  E-value: 2.59e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   71 PEIKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFPKSICTSINNIACHGIPD 150
Cdd:PRK12896   8 MEIKSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAIPSPEGYYGFPGSTCISVNEEVAHGIPG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  151 DRQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLAS 230
Cdd:PRK12896  88 PRVIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNGYSV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  231 IAAFIGHGIGSYFH-GPPEILHYYNEIPG-KMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITET 308
Cdd:PRK12896 168 VRDLTGHGVGRSLHeEPSVILTYTDPLPNrLLRPGMTLAVEPFLNLGAKDAETLDDGWTVVTPDKSLSAQFEHTVVVTRD 247


                 ....*.
gi 24583427  309 GTEILT 314
Cdd:PRK12896 248 GPEILT 253
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 72-314 6.67e-89

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 265.75  E-value: 6.67e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427    72 EIKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFPKSICTSINNIACHGIPDD 151
Cdd:TIGR00500   2 SLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPDK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   152 RQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASI 231
Cdd:TIGR00500  82 KVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   232 AAFIGHGIGSYFHGPPEILHYY-NEIPGKMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITETGT 310
Cdd:TIGR00500 162 REYCGHGIGRKFHEEPQIPNYGkKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNGP 241


                  ....
gi 24583427   311 EILT 314
Cdd:TIGR00500 242 EILT 245
PRK12318 PRK12318
methionyl aminopeptidase;
73-314 1.92e-78

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 240.88  E-value: 1.92e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   73 IKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAG--FPKSICTSINNIACHGIPD 150
Cdd:PRK12318  43 IKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELDELSRELHKEYNAIPAPLNYGSppFPKTICTSLNEVICHGIPN 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  151 DRQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLAS 230
Cdd:PRK12318 123 DIPLKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKVCQASLECLNAAIAILKPGIPLYEIGEVIENCADKYGFSV 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  231 IAAFIGHGIGSYFHGPPEILHYYNEIPGKMQPGMTFTIEPILSLGGAEiAVL--QDGWTAISLDGARSAQFEHTILITET 308
Cdd:PRK12318 203 VDQFVGHGVGIKFHENPYVPHHRNSSKIPLAPGMIFTIEPMINVGKKE-GVIdpINHWEARTCDNQPSAQWEHTILITET 281


                 ....*.
gi 24583427  309 GTEILT 314
Cdd:PRK12318 282 GYEILT 287
PRK12897 PRK12897
type I methionyl aminopeptidase;
73-315 4.06e-53

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 174.45  E-value: 4.06e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   73 IKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFPKSICTSINNIACHGIPDDR 152
Cdd:PRK12897   4 IKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEMCHAFPADV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  153 QLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASIA 232
Cdd:PRK12897  84 PLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFSVAR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  233 AFIGHGIGSYFHGPPEILHYYNEIPG-KMQPGMTFTIEPILSLGGAEIAVLQDGWTAISLDGARSAQFEHTILITETGTE 311
Cdd:PRK12897 164 DFTGHGIGKEIHEEPAIFHFGKQGQGpELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITKDGPI 243


                 ....
gi 24583427  312 ILTR 315
Cdd:PRK12897 244 ILTK 247
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 80-307 2.30e-50

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 165.88  E-value: 2.30e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427    80 DAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYpsplRYAGFPKSICTSINNIACHGIPDDRQLADGDI 159
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   160 INIDVTV-FLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASIAA-FIGH 237
Cdd:pfam00557  77 VLIDVGAeYDGGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFPhGLGH 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   238 GIGSYFHGPPEILHYYNEipGKMQPGMTFTIEPILSLggaeiavlqdgwtaisLDGARSAQFEHTILITE 307
Cdd:pfam00557 157 GIGLEVHEGPYISRGGDD--RVLEPGMVFTIEPGIYF----------------IPGWGGVRIEDTVLVTE 208
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 79-310 8.84e-41

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 141.05  E-value: 8.84e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  79 IDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAGFpksictSINNIACHGIPDDRQLADGD 158
Cdd:cd01066   1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGGYPAGPTIVGS------GARTALPHYRPDDRRLQEGD 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 159 IINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDL-ASIAAFIGH 237
Cdd:cd01066  75 LVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLgPNFGHRTGH 154

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24583427 238 GIGSYFHGPPEILHyynEIPGKMQPGMTFTIEPIlslggaeiavlqdgwtaISLDGARSAQFEHTILITETGT 310
Cdd:cd01066 155 GIGLEIHEPPVLKA---GDDTVLEPGMVFAVEPG-----------------LYLPGGGGVRIEDTVLVTEDGP 207
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
73-315 2.30e-30

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 116.46  E-value: 2.30e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  73 IKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAypsplRYAGFPkSICTSINNIA-CHGIPDD 151
Cdd:COG0006  73 IKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGA-----EGPSFD-TIVASGENAAiPHYTPTD 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 152 RQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLAS- 230
Cdd:COG0006 147 RPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEy 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 231 IAAFIGHGIGSYFHGPPeilHYYNEIPGKMQPGMTFTIEPILSLGGAEiavlqdgwtaisldGARSaqfEHTILITETGT 310
Cdd:COG0006 227 FPHGTGHGVGLDVHEGP---QISPGNDRPLEPGMVFTIEPGIYIPGIG--------------GVRI---EDTVLVTEDGA 286


                ....*
gi 24583427 311 EILTR 315
Cdd:COG0006 287 EVLTR 291
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 79-315 3.99e-30

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 115.43  E-value: 3.99e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  79 IDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPsplryaGFPKSIctSINNIACHGIP---DDRQLA 155
Cdd:cd01088   1 LEKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGP------AFPVNL--SINECAAHYTPnagDDTVLK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 156 DGDIINIDVTVFLNGYHGDCSETFRVGNVDERggfLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEHDLASIAAFI 235
Cdd:cd01088  73 EGDVVKLDFGAHVDGYIADSAFTVDFDPKYDD---LLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLT 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 236 GHGIGSY-FHGPPEILHYYNEIPGKMQPGMTFTIEPILSLGGAEiaVLQDGWTAI------------------------- 289
Cdd:cd01088 150 GHSIERYrLHAGKSIPNVKGGEGTRLEEGDVYAIEPFATTGKGY--VHDGPECSIymlnrdkplrlprarklldviyenf 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24583427 290 --------------------------------------SLDGARSAQFEHTILITETGTEILTR 315
Cdd:cd01088 228 gtlpfarrwldrlgetkllmalknlckagivypypvlkEISGGYVAQFEHTIIVREDGKEVTTR 291
PRK07281 PRK07281
methionyl aminopeptidase;
73-314 3.08e-27

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 107.63  E-value: 3.08e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   73 IKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAYPSPLRYAG----FPKSICTSINNIACHGI 148
Cdd:PRK07281   4 LKSAREIEAMDRAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENVLPLQIGVDGammdYPYATCCGLNDEVAHAF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  149 PDDRQLADGDIINIDVTV------------------------FLNGYHGDCSET---FRVGNVDERGGFLVEATKSCLDQ 201
Cdd:PRK07281  84 PRHYILKEGDLLKVDMVLsepldksivdvsklnfdnveqmkkYTESYRGGLADScwaYAVGTPSDEVKNLMDVTKEAMYR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  202 CISLCGPGVEFNEIGKFIDRYCDEHDLASIAAFIGHGIGSYFHGPPEILHYYNEIPG-KMQPGMTFTIEPILSLGGAEIA 280
Cdd:PRK07281 164 GIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGlRLREGMVLTIEPMINTGTWEID 243

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 24583427  281 V-LQDGWTAISLDGARSAQFEHTILITETGTEILT 314
Cdd:PRK07281 244 TdMKTGWAHKTLDGGLSCQYEHQFVITKDGPVILT 278
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 79-309 1.64e-18

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 82.17  E-value: 1.64e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  79 IDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILESKAY-PSplryagFPkSICTSINNIA-CHGIPDDRQLAD 156
Cdd:cd01092   1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEgPS------FD-TIVASGPNSAlPHGVPSDRKIEE 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 157 GDIINIDVTVFLNGYHGDCSETFRVGNVDERggfLVEATKSCLD---QCISLCGPGVEFNEIGKFIDRYCDEHDLAsiAA 233
Cdd:cd01092  74 GDLVLIDFGAIYDGYCSDITRTVAVGEPSDE---LKEIYEIVLEaqqAAIKAVKPGVTAKEVDKAARDVIEEAGYG--EY 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 234 FI---GHGIGSYFHGPPEILHYYNeipGKMQPGMTFTIEP---ILSLGGAEIavlqdgwtaisldgarsaqfEHTILITE 307
Cdd:cd01092 149 FIhrtGHGVGLEVHEAPYISPGSD---DVLEEGMVFTIEPgiyIPGKGGVRI--------------------EDDVLVTE 205


                ..
gi 24583427 308 TG 309
Cdd:cd01092 206 DG 207
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 83-237 3.33e-11

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 61.96  E-value: 3.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  83 RLSGRLAARILRECGKLATVGTTTDQI----DAFAHERIleSKAYPSPLRYA---GFPKSIctSINNIACHGIP----DD 151
Cdd:cd01089   5 KTAGQIANKVLKQVISLCVPGAKVVDLcekgDKLILEEL--GKVYKKEKKLEkgiAFPTCI--SVNNCVCHFSPlksdAT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 152 RQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDE-----RGGFLVEATKSCLDQCISLCGPGVEFNEIGKFIDRYCDEH 226
Cdd:cd01089  81 YTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAEtpvtgKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                       170
                ....*....|.
gi 24583427 227 DLASIAAFIGH 237
Cdd:cd01089 161 GCTPVEGVLSH 171
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 131-315 2.44e-10

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 60.88  E-value: 2.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  131 GFPKSiCtSINNIACHGIP---DDRQLADGDIINIDVTVFLNGYHGDCSET--FrvgnvDERGGFLVEATKSCLDQCISL 205
Cdd:PTZ00053 210 AFPTG-C-SLNHCAAHYTPntgDKTVLTYDDVCKLDFGTHVNGRIIDCAFTvaF-----NPKYDPLLQATKDATNTGIKE 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  206 CGPGVEFNEIGKFIDRYCDEHDL---------ASIAAFIGHGIGSYfhgppeILHYYNEIP-------GKMQPGMTFTIE 269
Cdd:PTZ00053 283 AGIDVRLSDIGAAIQEVIESYEVeikgktypiKSIRNLNGHSIGPY------IIHGGKSVPivkggenTRMEEGELFAIE 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  270 PILSLG-----------------GAEIAVL---------------------------QDGWT--AISLD----------- 292
Cdd:PTZ00053 357 TFASTGrgyvnedlecshymkdpGAEFVPLrlpkakqllkhintnfgtlafcrrwldRLGQDrhLLALKqlvdagivnpy 436

                        250       260       270
                 ....*....|....*....|....*....|
gi 24583427  293 -------GARSAQFEHTILITETGTEILTR 315
Cdd:PTZ00053 437 pplcdvrGSYTSQMEHTILLRPTCKEVLSR 466
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 67-237 5.38e-09

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 56.82  E-value: 5.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427    67 TLGSPEIksqvqIDAMRLSGRLAARILR----ECGKLATVGTTTDQIDAFAHERIleSKAYPSPLR-YAGFPKSICTSIN 141
Cdd:TIGR00495  13 SLSNPEV-----VTKYKMAGEIANNVLKsvveACSPGAKVVDICEKGDAFIMEET--AKIFKKEKEmEKGIAFPTCISVN 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   142 NIACHGIP----DDRQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDE-----RGGFLVEATKSCLDQCISLCGPGVEF 212
Cdd:TIGR00495  86 NCVGHFSPlksdQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEepvtgRKADVIAAAHLAAEAALRLVKPGNTN 165

                         170       180
                  ....*....|....*....|....*
gi 24583427   213 NEIGKFIDRYCDEHDLASIAAFIGH 237
Cdd:TIGR00495 166 TQVTEAINKVAHSYGCTPVEGMLSH 190
Creatinase cd01090
Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.
 140-314 2.83e-08

Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.


Pssm-ID: 238523 [Multi-domain]  Cd Length: 228  Bit Score: 53.31  E-value: 2.83e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 140 INNIACHGIPDDRQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIGKFI 219
Cdd:cd01090  63 INTDGAHNPVTNRKVQRGDILSLNCFPMIAGYYTALERTLFLDEVSDAHLKIWEANVAVHERGLELIKPGARCKDIAAEL 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 220 DRYCDEHDLASIAAF-IGHGIG--SYFHGPPEILHYYNEIPGKMQPGMTFTIEPILSLGGAEIAVlqdgwtaislDGARs 296
Cdd:cd01090 143 NEMYREHDLLRYRTFgYGHSFGvlSHYYGREAGLELREDIDTVLEPGMVVSMEPMIMLPEGQPGA----------GGYR- 211

                       170
                ....*....|....*....
gi 24583427 297 aqfEHTIL-ITETGTEILT 314
Cdd:cd01090 212 ---EHDILvINENGAENIT 227
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 79-315 7.90e-08

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 52.19  E-value: 7.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  79 IDAMRLSGRLAARILRECGKLATVGTTTDQIDAfaherILESKAYPSPLRYAGFPKSICTSinNIAC-HGIPDDRQLADG 157
Cdd:cd01087   1 IELMRKACDISAEAHRAAMKASRPGMSEYELEA-----EFEYEFRSRGARLAYSYIVAAGS--NAAIlHYVHNDQPLKDG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 158 DIINIDVTVFLNGYHGDCSETFRV-GNVDERGGFLVEATKSCLDQCISLCGPGVEFNEI----GKFIDRYCDEHDLAS-- 230
Cdd:cd01087  74 DLVLIDAGAEYGGYASDITRTFPVnGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIhllaHRVLAEGLKELGILKgd 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427 231 ---------IAAFIGHGIGSYF----HGPPEiLHYYNEIPGKMQPGMTFTIEPILSLGGAEIAVLQDgWTAIsldGARsa 297
Cdd:cd01087 154 vdeivesgaYAKFFPHGLGHYLgldvHDVGG-YLRYLRRARPLEPGMVITIEPGIYFIPDLLDVPEY-FRGG---GIR-- 226

                       250
                ....*....|....*...
gi 24583427 298 qFEHTILITETGTEILTR 315
Cdd:cd01087 227 -IEDDVLVTEDGPENLTR 243
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 73-314 1.01e-07

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 52.80  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   73 IKSQVQIDAMRLSGRLAA----RILRECGKlatvGTTTDQIDA-FAHERILESKAYPSplrYagfpKSICTSINNiAC-- 145
Cdd:PRK10879 173 FKSPEEIAVLRRAGEISAlahtRAMEKCRP----GMFEYQLEGeIHHEFNRHGARYPS---Y----NTIVGSGEN-GCil 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  146 HGIPDDRQLADGDIINIDVTVFLNGYHGDCSETFRVGnvderGGF---------LVEATkscLDQCISLCGPGVEFNEIG 216
Cdd:PRK10879 241 HYTENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVN-----GKFtpaqreiydIVLES---LETSLRLYRPGTSIREVT 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  217 KFIDRYC-------------DEHDLASIA--AFIGHGIGSYF----HgppEILHYYNEIPGKMQPGMTFTIEPILSLggA 277
Cdd:PRK10879 313 GEVVRIMvsglvklgilkgdVDQLIAENAhrPFFMHGLSHWLgldvH---DVGVYGQDRSRILEPGMVLTVEPGLYI--A 387

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 24583427  278 EIAVLQDGWTAIsldGARsaqFEHTILITETGTEILT 314
Cdd:PRK10879 388 PDADVPEQYRGI---GIR---IEDDIVITETGNENLT 418
PRK15173 PRK15173
peptidase; Provisional
 73-215 3.03e-06

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 48.17  E-value: 3.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   73 IKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAfAHERILESKAYPSPLRYagfpkSICTSINNIACHGIPDDR 152
Cdd:PRK15173  95 IKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTA-AYKAAVMSKSETHFSRF-----HLISVGADFSPKLIPSNT 168

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24583427  153 QLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEI 215
Cdd:PRK15173 169 KACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDV 231
PRK14575 PRK14575
putative peptidase; Provisional
 73-215 4.70e-06

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 47.78  E-value: 4.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   73 IKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAfAHERILESKAYPSPLRYagfpkSICTSINNIACHGIPDDR 152
Cdd:PRK14575 178 IKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTA-AYKAAVMSKSETHFSRF-----HLISVGADFSPKLIPSNT 251

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24583427  153 QLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEI 215
Cdd:PRK14575 252 KACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDV 314
PRK14576 PRK14576
putative endopeptidase; Provisional
 73-315 3.50e-05

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 45.01  E-value: 3.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   73 IKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDAFAHERILeskAYPSplryAGFPKSICTSI-NNIACHGIPDD 151
Cdd:PRK14576 177 IKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVM---SFPE----TNFSRFNLISVgDNFSPKIIADT 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  152 RQLADGDIINIDVTVFLNGYHGDCSETFRVGNVDERGGFLVEATKSCLDQCISLCGPGVEFNEIgkfIDRYCDEHDLASI 231
Cdd:PRK14576 250 TPAKVGDLIKFDCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAV---FDSTMAVIKTSGL 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  232 AAF----IGHGIGsYFHGPPEILHYYNEIPGKMQPGMTFTIE-PILSLGGAEIavlqdgwtaisldgarsaQFEHTILIT 306
Cdd:PRK14576 327 PHYnrghLGHGDG-VFLGLEEVPFVSTQATETFCPGMVLSLEtPYYGIGVGSI------------------MLEDMILIT 387


                 ....*....
gi 24583427  307 ETGTEILTR 315
Cdd:PRK14576 388 DSGFEFLSK 396
PRK09795 PRK09795
aminopeptidase; Provisional
 72-313 3.52e-05

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 44.93  E-value: 3.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427   72 EIKSQVQIDAMRLSGRLAARILRECGKLATVGTTTDQIDA----FAHERILESkaypsplryAGFPKSICTSINNIACHG 147
Cdd:PRK09795 126 QIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAelewFMRQQGAEK---------ASFDTIVASGWRGALPHG 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  148 IPDDRQLADGDIINIDVTVFLNGYHGDCSETFRVGNVD--ERGGFLVEATKSCLD---QCISLCGPGVEFNEIGKFIDRY 222
Cdd:PRK09795 197 KASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGvsAESHPLFNVYQIVLQaqlAAISAIRPGVRCQQVDDAARRV 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583427  223 CDEHDLASIAAF-IGHGIGSYFHGPPEILHYYNEIpgkMQPGMTFTIEPilslggaeiavlqdgwtAISLDGARSAQFEH 301
Cdd:PRK09795 277 ITEAGYGDYFGHnTGHAIGIEVHEDPRFSPRDTTT---LQPGMLLTVEP-----------------GIYLPGQGGVRIED 336

                        250
                 ....*....|..
gi 24583427  302 TILITETGTEIL 313
Cdd:PRK09795 337 VVLVTPQGAEVL 348
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 236-270 1.29e-04

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 42.55  E-value: 1.29e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24583427 236 GHGIGSYF--H-GPPEILHYYNEIPgkMQPGMTFTIEP 270
Cdd:cd01085 161 GHGVGSFLnvHeGPQSISPAPNNVP--LKAGMILSNEP 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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