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Conserved domains on  [gi|19920938|ref|NP_609217|]
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WD repeat domain 82 [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-303 6.81e-50

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 6.81e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  14 KVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAIHSSTkvDDTIRY 93
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  94 LSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPI--AAYDPEGLIFAAGVNSE 171
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVrsVAFSPDGRLLASGSADG 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 172 SIKLYDLRSfdkGPFVTFKLNQEkecDW-TGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPnnkGIPIEASFS 250
Cdd:COG2319 269 TVRLWDLAT---GELLRTLTGHS---GGvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT---GAVRSVAFS 339

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19920938 251 PDSQFIFSGSTDGRVHIWNADTGNKVSVLNGdHPGPVQCVQFNPKYMMLASAC 303
Cdd:COG2319 340 PDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGS 391
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-303 6.81e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 6.81e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  14 KVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAIHSSTkvDDTIRY 93
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  94 LSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPI--AAYDPEGLIFAAGVNSE 171
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVrsVAFSPDGRLLASGSADG 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 172 SIKLYDLRSfdkGPFVTFKLNQEkecDW-TGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPnnkGIPIEASFS 250
Cdd:COG2319 269 TVRLWDLAT---GELLRTLTGHS---GGvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT---GAVRSVAFS 339

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19920938 251 PDSQFIFSGSTDGRVHIWNADTGNKVSVLNGdHPGPVQCVQFNPKYMMLASAC 303
Cdd:COG2319 340 PDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGS 391
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-302 1.07e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.03  E-value: 1.07e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  17 KIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAIhsSTKVDDTIRYLSL 96
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLA--SGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  97 HDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPI--AAYDPEGLIFAAGVNSESIK 174
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVnsVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 175 LYDLRSFdkGPFVTFKLNQekecDW-TGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNnkgIPIEASFSPDS 253
Cdd:cd00200 161 LWDLRTG--KCVATLTGHT----GEvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN---GVNSVAFSPDG 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 19920938 254 QFIFSGSTDGRVHIWNADTGNKVSVLNGdHPGPVQCVQFNPKYMMLASA 302
Cdd:cd00200 232 YLLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASG 279
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 28-293 4.59e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 4.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938   28 AIDFAPNGEHLISCSEDDQIVIYDCEKgtqsrTVNSKKYgvdlIHFTHAN------------NTAIHS---STKVDDTIR 92
Cdd:PLN00181 488 AIGFDRDGEFFATAGVNKKIKIFECES-----IIKDGRD----IHYPVVElasrsklsgicwNSYIKSqvaSSNFEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938   93 YLSLHDNKYLRYFPGHTKKVISLCISPVEDTFL-SGSLDKTLRLWDLRSPNCQGLMHLSGRPIAAYDPE--GLIFAAGVN 169
Cdd:PLN00181 559 VWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSesGRSLAFGSA 638

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  170 SESIKLYDLRSfDKGPFVTFkLNQEKECDWtgLKFSrDGKTILISTNGSVIRLVD------AFHGTPLQTFTGYPNNKgi 243
Cdd:PLN00181 639 DHKVYYYDLRN-PKLPLCTM-IGHSKTVSY--VRFV-DSSTLVSSSTDNTLKLWDlsmsisGINETPLHSFMGHTNVK-- 711

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 19920938  244 pieasfspdsQFIFSGSTDGrvHIWNADTGNKVSVLNGDHPGPVQCVQFN 293
Cdd:PLN00181 712 ----------NFVGLSVSDG--YIATGSETNEVFVYHKAFPMPVLSYKFK 749
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 7.54e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 7.54e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19920938     98 DNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWD 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-137 9.70e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 9.70e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19920938    99 NKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWD 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-303 6.81e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 6.81e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  14 KVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAIHSSTkvDDTIRY 93
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  94 LSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPI--AAYDPEGLIFAAGVNSE 171
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVrsVAFSPDGRLLASGSADG 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 172 SIKLYDLRSfdkGPFVTFKLNQEkecDW-TGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPnnkGIPIEASFS 250
Cdd:COG2319 269 TVRLWDLAT---GELLRTLTGHS---GGvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT---GAVRSVAFS 339

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19920938 251 PDSQFIFSGSTDGRVHIWNADTGNKVSVLNGdHPGPVQCVQFNPKYMMLASAC 303
Cdd:COG2319 340 PDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGS 391
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-302 1.07e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.03  E-value: 1.07e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  17 KIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAIhsSTKVDDTIRYLSL 96
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLA--SGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  97 HDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPI--AAYDPEGLIFAAGVNSESIK 174
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVnsVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 175 LYDLRSFdkGPFVTFKLNQekecDW-TGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNnkgIPIEASFSPDS 253
Cdd:cd00200 161 LWDLRTG--KCVATLTGHT----GEvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN---GVNSVAFSPDG 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 19920938 254 QFIFSGSTDGRVHIWNADTGNKVSVLNGdHPGPVQCVQFNPKYMMLASA 302
Cdd:cd00200 232 YLLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
3-272 1.82e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.53  E-value: 1.82e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938   3 IKLIDsvVRSFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNT-AI 81
Cdd:COG2319 144 VRLWD--LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLlAS 221

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  82 HSStkvDDTIRYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPI--AAYDP 159
Cdd:COG2319 222 GSA---DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVnsVAFSP 298

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 160 EGLIFAAGVNSESIKLYDLRSFDkgPFVTFKLNQEkecDWTGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPN 239
Cdd:COG2319 299 DGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTG---AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG 373

                       250       260       270
                ....*....|....*....|....*....|....
gi 19920938 240 nkgiPIEA-SFSPDSQFIFSGSTDGRVHIWNADT 272
Cdd:COG2319 374 ----AVTSvAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
10-302 3.26e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.45  E-value: 3.26e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  10 VRSFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAIHSSTkvDD 89
Cdd:COG2319  65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSA--DG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  90 TIRYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPI--AAYDPEGLIFAAG 167
Cdd:COG2319 143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVrsVAFSPDGKLLASG 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 168 VNSESIKLYDLRSfdKGPFVTFKLNQekecDW-TGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNnkgiPIE 246
Cdd:COG2319 223 SADGTVRLWDLAT--GKLLRTLTGHS----GSvRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG----GVN 292

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19920938 247 A-SFSPDSQFIFSGSTDGRVHIWNADTGNKVSVLNGdHPGPVQCVQFNPKYMMLASA 302
Cdd:COG2319 293 SvAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
26-303 6.20e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 6.20e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  26 INAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAIHSSTkvDDTIRYLSLHDNKYLRYF 105
Cdd:COG2319  39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA--DGTVRLWDLATGLLLRTL 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 106 PGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCqgLMHLSGRPIA----AYDPEGLIFAAGVNSESIKLYDLRSF 181
Cdd:COG2319 117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL--LRTLTGHSGAvtsvAFSPDGKLLASGSDDGTVRLWDLATG 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 182 DkgPFVTFKLNQekecDW-TGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNnkgiPIEA-SFSPDSQFIFSG 259
Cdd:COG2319 195 K--LLRTLTGHT----GAvRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG----SVRSvAFSPDGRLLASG 264

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 19920938 260 STDGRVHIWNADTGNKVSVLNGdHPGPVQCVQFNPKYMMLASAC 303
Cdd:COG2319 265 SADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGS 307
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-269 2.74e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.81  E-value: 2.74e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  10 VRSFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAIHSSTkvDD 89
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ--DG 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  90 TIRYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSGRPI--AAYDPEGLIFAAG 167
Cdd:cd00200 158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVnsVAFSPDGYLLASG 237

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 168 VNSESIKLYDLRSfdkgpfvtfklnqekecdwtglkfsrdgktilistngsvirlvdafhGTPLQTFTGYPNnkgiPIEA 247
Cdd:cd00200 238 SEDGTIRVWDLRT-----------------------------------------------GECVQTLSGHTN----SVTS 266

                       250       260
                ....*....|....*....|...
gi 19920938 248 -SFSPDSQFIFSGSTDGRVHIWN 269
Cdd:cd00200 267 lAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-310 1.14e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.27  E-value: 1.14e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 102 LRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLM--H-LSGRPIAAYDPEGLIFAAGVNSeSIKLYDL 178
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkgHtGPVRDVAASADGTYLASGSSDK-TIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 179 RSFDkgpfVTFKLNQEkECDWTGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNnkgiPIEA-SFSPDSQFIF 257
Cdd:cd00200  81 ETGE----CVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD----WVNSvAFSPDGTFVA 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 19920938 258 SGSTDGRVHIWNADTGNKVSVLNGdHPGPVQCVQFNPKYMMLASACTNMAFWL 310
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
2-140 4.53e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 4.53e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938   2 KIKLIDsvVRSFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAI 81
Cdd:COG2319 269 TVRLWD--LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLA 346

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19920938  82 HSSTkvDDTIRYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLRS 140
Cdd:COG2319 347 SGSD--DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-137 4.21e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 4.21e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938   3 IKLIDsvVRSFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHANNTAih 82
Cdd:cd00200 159 IKLWD--LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLL-- 234

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19920938  83 SSTKVDDTIRYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWD 137
Cdd:cd00200 235 ASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 28-293 4.59e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 4.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938   28 AIDFAPNGEHLISCSEDDQIVIYDCEKgtqsrTVNSKKYgvdlIHFTHAN------------NTAIHS---STKVDDTIR 92
Cdd:PLN00181 488 AIGFDRDGEFFATAGVNKKIKIFECES-----IIKDGRD----IHYPVVElasrsklsgicwNSYIKSqvaSSNFEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938   93 YLSLHDNKYLRYFPGHTKKVISLCISPVEDTFL-SGSLDKTLRLWDLRSPNCQGLMHLSGRPIAAYDPE--GLIFAAGVN 169
Cdd:PLN00181 559 VWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSesGRSLAFGSA 638

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  170 SESIKLYDLRSfDKGPFVTFkLNQEKECDWtgLKFSrDGKTILISTNGSVIRLVD------AFHGTPLQTFTGYPNNKgi 243
Cdd:PLN00181 639 DHKVYYYDLRN-PKLPLCTM-IGHSKTVSY--VRFV-DSSTLVSSSTDNTLKLWDlsmsisGINETPLHSFMGHTNVK-- 711

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 19920938  244 pieasfspdsQFIFSGSTDGrvHIWNADTGNKVSVLNGDHPGPVQCVQFN 293
Cdd:PLN00181 712 ----------NFVGLSVSDG--YIATGSETNEVFVYHKAFPMPVLSYKFK 749
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 7.54e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 7.54e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19920938     98 DNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWD 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-137 9.70e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 9.70e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19920938    99 NKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWD 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 12-51 1.32e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.32e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19920938     12 SFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYD 51
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 204-283 1.57e-05

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 44.28  E-value: 1.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 204 FSRDGKTILISTN---GSVIRLVDAFHGTPLQ-TFTGYPNNkgipiEASFSPDSQFI-FSGSTDGRVHIW--NADTGNKV 276
Cdd:COG0823  38 WSPDGRRIAFTSDrggGPQIYVVDADGGEPRRlTFGGGYNA-----SPSWSPDGKRLaFVSRSDGRFDIYvlDLDGGAPR 112


                ....*..
gi 19920938 277 SVLNGDH 283
Cdd:COG0823 113 RLTDGPG 119
WD40 pfam00400
WD domain, G-beta repeat;
13-51 1.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19920938    13 FKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYD 51
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-269 5.51e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 5.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 19920938    228 GTPLQTFTGYPNnkgiPIEA-SFSPDSQFIFSGSTDGRVHIWN 269
Cdd:smart00320   2 GELLKTLKGHTG----PVTSvAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
124-273 5.65e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.83  E-value: 5.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 124 FLSGSLDKTLRLWDLRSPNCQGLMHLSGRPIA-AYDPEG-LIFAAGVNSESIKLYDLRSFDkgpfVTFKLNQEKECdwTG 201
Cdd:COG3391  83 YVANSGSGRVSVIDLATGKVVATIPVGGGPRGlAVDPDGgRLYVADSGNGRVSVIDTATGK----VVATIPVGAGP--HG 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938 202 LKFSRDGKTILISTNGS-----VIRLVDAFHGTPLQTF-TGypnnkGIPIEASFSPDSQFIF--------SGSTDGRVHI 267
Cdd:COG3391 157 IAVDPDGKRLYVANSGSntvsvIVSVIDTATGKVVATIpVG-----GGPVGVAVSPDGRRLYvanrgsntSNGGSNTVSV 231


                ....*.
gi 19920938 268 WNADTG 273
Cdd:COG3391 232 IDLATL 237
WD40 pfam00400
WD domain, G-beta repeat;
228-269 6.55e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 6.55e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 19920938   228 GTPLQTFTGYPNnkgiPIEA-SFSPDSQFIFSGSTDGRVHIWN 269
Cdd:pfam00400   1 GKLLKTLEGHTG----SVTSlAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 200-281 7.88e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.18  E-value: 7.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920938  200 TGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGyPNNKGIpIEASFSPDSQFI-FSGSTD---GRVHIWNADTGNK 275
Cdd:COG4946  392 FNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRKVDTD-GYGDGI-SDLAWSPDSKWLaYSKPGPnqlSQIFLYDVETGKT 469


                 ....*.
gi 19920938  276 VSVLNG 281
Cdd:COG4946  470 VQLTDG 475
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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