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Conserved domains on  [gi|19920508|ref|NP_608584|]
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uncharacterized protein Dmel_CG5126 [Drosophila melanogaster]

Protein Classification

protein kinase family protein( domain architecture ID 10503049)

protein kinase family protein, similar to Bombyx mori EcKinase that catalyzes the phosphorylation of the steroid hormone and together with ecdysteroid-phosphate phosphatase, plays an important role in ecdysteroid economy of the ovary-egg system

CATH:  1.10.510.10
EC:  2.7.-.-
Gene Ontology:  GO:0016310|GO:0005524|GO:0016301
PubMed:  16244704
SCOP:  4003661

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
EcKL pfam02958
Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme ...
41-353 8.16e-74

Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates. Most insects contain 12 to 105 genes encoding this family and yet so far only one enzyme (ecdysteroid 22-kinase from Bombyx mori) has characterized substrates (2-deoxyecdysone, ecdysone, 20-hydroxyecdysone). There are good reasons to believe that this family includes kinases that act on other small molecule substrates and that they may function in detoxification processes.


:

Pssm-ID: 397213 [Multi-domain]  Cd Length: 293  Bit Score: 233.70  E-value: 8.16e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508    41 DGFMSALYTVTLDVVI-AERKRTEVVLVKFMKGTEEFRESSNSYIQFSNEIFAYAEILPAYENVLRtshlESEVVKNWVP 119
Cdd:pfam02958   3 DNYASVMLRVTIEYEKgDGSKRTKSLIVKTMPDNEERREMFSSLNLFTREINMYEKVLPELEALYR----EAGDPFKLAP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508   120 CCYFARfghveglGNGRESVLALKHLKGDGYQLGPRL-TLRRDQLEAMVGLVGPFHALGYATKILQPNVHARLRAGVVDM 198
Cdd:pfam02958  79 KCYYAD-------LEPEDQVIILEDLSLKGYKNADRLkGLDLEHTKLVLEKLAKFHAASAALKELQPEVFKQLKKGLFEE 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508   199 PFVSSSGKGIFDVLYRVAFDRFYEFYDRQKEQLLQGAdpgfgAAIERLREKYFKQPTLLLErirtssfaedQPDSHFATF 278
Cdd:pfam02958 152 DYVNGAIKEFFEPLMETGLDAAAEALREQLPEYEKYA-----EKLEKLKDNYFDRLLRLVE----------PTPGEFNVL 216
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19920508   279 LHGDYNRNNVLFHYGAEDKVDAIKAIDFQELRFSTTAIDLSFFMYMNTPSEGRKEIYADLLRKYHRSMIEMLELV 353
Cdd:pfam02958 217 NHGDLWVNNIMFKYDDEGEPEDVILVDFQLSRYGSPAIDLNYFLYTSTELELRLEHFDELLRYYHSSLVETLKKL 291
 
Name Accession Description Interval E-value
EcKL pfam02958
Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme ...
41-353 8.16e-74

Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates. Most insects contain 12 to 105 genes encoding this family and yet so far only one enzyme (ecdysteroid 22-kinase from Bombyx mori) has characterized substrates (2-deoxyecdysone, ecdysone, 20-hydroxyecdysone). There are good reasons to believe that this family includes kinases that act on other small molecule substrates and that they may function in detoxification processes.


Pssm-ID: 397213 [Multi-domain]  Cd Length: 293  Bit Score: 233.70  E-value: 8.16e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508    41 DGFMSALYTVTLDVVI-AERKRTEVVLVKFMKGTEEFRESSNSYIQFSNEIFAYAEILPAYENVLRtshlESEVVKNWVP 119
Cdd:pfam02958   3 DNYASVMLRVTIEYEKgDGSKRTKSLIVKTMPDNEERREMFSSLNLFTREINMYEKVLPELEALYR----EAGDPFKLAP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508   120 CCYFARfghveglGNGRESVLALKHLKGDGYQLGPRL-TLRRDQLEAMVGLVGPFHALGYATKILQPNVHARLRAGVVDM 198
Cdd:pfam02958  79 KCYYAD-------LEPEDQVIILEDLSLKGYKNADRLkGLDLEHTKLVLEKLAKFHAASAALKELQPEVFKQLKKGLFEE 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508   199 PFVSSSGKGIFDVLYRVAFDRFYEFYDRQKEQLLQGAdpgfgAAIERLREKYFKQPTLLLErirtssfaedQPDSHFATF 278
Cdd:pfam02958 152 DYVNGAIKEFFEPLMETGLDAAAEALREQLPEYEKYA-----EKLEKLKDNYFDRLLRLVE----------PTPGEFNVL 216
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19920508   279 LHGDYNRNNVLFHYGAEDKVDAIKAIDFQELRFSTTAIDLSFFMYMNTPSEGRKEIYADLLRKYHRSMIEMLELV 353
Cdd:pfam02958 217 NHGDLWVNNIMFKYDDEGEPEDVILVDFQLSRYGSPAIDLNYFLYTSTELELRLEHFDELLRYYHSSLVETLKKL 291
CHK smart00587
ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases
140-352 8.89e-33

ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases


Pssm-ID: 214734  Cd Length: 196  Bit Score: 122.82  E-value: 8.89e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508    140 LALKHLKGDGYQLGPRLTLRRDQLEAMVglVGPFHALGYATKILQPNVHarlragvvdMPFVSSSGKGIFDVLYRVAFDR 219
Cdd:smart00587   1 IIFEDLSPKGYVNADRLKGLDLEHTSLV--LKKLAKLHAASAVLIEEEK---------GSYLEEFDEGLFERFKRMFSEE 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508    220 FYEFYDRQKEQLLQGADPGFgaaIERLREKYFKQPTLLLERIRTSSFAEDQpdsHFATFLHGDYNRNNVLFHYGAEDKVD 299
Cdd:smart00587  70 FIGGLENFLRELLSQPELLK---VEEYIEKLDKLLDNLEDLKKEDKEPDEG---EFNVLNHGDLWANNIMFKYDDEGKPE 143
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 19920508    300 AIKAIDFQELRFSTTAIDLSFFMYMNTPSEGRKEIYADLLRKYHRSMIEMLEL 352
Cdd:smart00587 144 DVALIDFQLSHYGSPAEDLHYFLLTSLSVEIRREHFDELLKFYYETLVETLKK 196
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
231-344 4.21e-03

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 38.94  E-value: 4.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508 231 LLQGADPGFGAAIERLREKYFKQPT------LLLERIRTSsFAEDQPDSHFATFLHGDYNRNNVLFHyGAEDKVDAIkaI 304
Cdd:COG3173 142 LADGRPEGLERQLARWRAQLRRALArtddlpALRERLAAW-LAANLPEWGPPVLVHGDLRPGNLLVD-PDDGRLTAV--I 217
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 19920508 305 DFQELRFSTTAIDLSFFMYMNTPSEGRKEIYADLLRKYHR 344
Cdd:COG3173 218 DWELATLGDPAADLAYLLLYWRLPDDLLGPRAAFLAAYEE 257
 
Name Accession Description Interval E-value
EcKL pfam02958
Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme ...
41-353 8.16e-74

Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates. Most insects contain 12 to 105 genes encoding this family and yet so far only one enzyme (ecdysteroid 22-kinase from Bombyx mori) has characterized substrates (2-deoxyecdysone, ecdysone, 20-hydroxyecdysone). There are good reasons to believe that this family includes kinases that act on other small molecule substrates and that they may function in detoxification processes.


Pssm-ID: 397213 [Multi-domain]  Cd Length: 293  Bit Score: 233.70  E-value: 8.16e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508    41 DGFMSALYTVTLDVVI-AERKRTEVVLVKFMKGTEEFRESSNSYIQFSNEIFAYAEILPAYENVLRtshlESEVVKNWVP 119
Cdd:pfam02958   3 DNYASVMLRVTIEYEKgDGSKRTKSLIVKTMPDNEERREMFSSLNLFTREINMYEKVLPELEALYR----EAGDPFKLAP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508   120 CCYFARfghveglGNGRESVLALKHLKGDGYQLGPRL-TLRRDQLEAMVGLVGPFHALGYATKILQPNVHARLRAGVVDM 198
Cdd:pfam02958  79 KCYYAD-------LEPEDQVIILEDLSLKGYKNADRLkGLDLEHTKLVLEKLAKFHAASAALKELQPEVFKQLKKGLFEE 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508   199 PFVSSSGKGIFDVLYRVAFDRFYEFYDRQKEQLLQGAdpgfgAAIERLREKYFKQPTLLLErirtssfaedQPDSHFATF 278
Cdd:pfam02958 152 DYVNGAIKEFFEPLMETGLDAAAEALREQLPEYEKYA-----EKLEKLKDNYFDRLLRLVE----------PTPGEFNVL 216
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19920508   279 LHGDYNRNNVLFHYGAEDKVDAIKAIDFQELRFSTTAIDLSFFMYMNTPSEGRKEIYADLLRKYHRSMIEMLELV 353
Cdd:pfam02958 217 NHGDLWVNNIMFKYDDEGEPEDVILVDFQLSRYGSPAIDLNYFLYTSTELELRLEHFDELLRYYHSSLVETLKKL 291
CHK smart00587
ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases
140-352 8.89e-33

ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases


Pssm-ID: 214734  Cd Length: 196  Bit Score: 122.82  E-value: 8.89e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508    140 LALKHLKGDGYQLGPRLTLRRDQLEAMVglVGPFHALGYATKILQPNVHarlragvvdMPFVSSSGKGIFDVLYRVAFDR 219
Cdd:smart00587   1 IIFEDLSPKGYVNADRLKGLDLEHTSLV--LKKLAKLHAASAVLIEEEK---------GSYLEEFDEGLFERFKRMFSEE 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508    220 FYEFYDRQKEQLLQGADPGFgaaIERLREKYFKQPTLLLERIRTSSFAEDQpdsHFATFLHGDYNRNNVLFHYGAEDKVD 299
Cdd:smart00587  70 FIGGLENFLRELLSQPELLK---VEEYIEKLDKLLDNLEDLKKEDKEPDEG---EFNVLNHGDLWANNIMFKYDDEGKPE 143
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 19920508    300 AIKAIDFQELRFSTTAIDLSFFMYMNTPSEGRKEIYADLLRKYHRSMIEMLEL 352
Cdd:smart00587 144 DVALIDFQLSHYGSPAEDLHYFLLTSLSVEIRREHFDELLKFYYETLVETLKK 196
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
217-344 1.90e-05

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 45.96  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508   217 FDRFYEFYDRQ-KEQLLQGADPGFGAAIERLREKYFKQptlllerirtssFAEDQPDSHFATFLHGDYNRNNVLFHYGae 295
Cdd:pfam01636 119 RLARLLELLRQlEAALARLLAAELLDRLEELEERLLAA------------LLALLPAELPPVLVHGDLHPGNLLVDPG-- 184
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 19920508   296 DKVDAIkaIDFQELRFSTTAIDLSfFMYMNTPSEGRKEIYADLLRKYHR 344
Cdd:pfam01636 185 GRVSGV--IDFEDAGLGDPAYDLA-ILLNSWGRELGAELLAAYLAAYGA 230
DUF1679 pfam07914
Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number ...
274-351 1.05e-03

Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number of C. elegans proteins, in one case as a repeat. In many of the family members, this region is associated with the CHK region described by SMART as being found in ZnF_C4 and HLH domain-containing kinases. In fact, one member of this family is annotated as being a member of the nuclear hormone receptor family, and contains regions typical of such proteins (Interpro:IPR000536, Interpro:IPR008946, and Interpro:IPR001628).


Pssm-ID: 369592  Cd Length: 413  Bit Score: 41.11  E-value: 1.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19920508   274 HFATFLHGDYNRNNVLFHYGAEDKVDAIKAIDFQELRFSTTAIDLSFFMyMNTPS-EGRKEIYADLLRKYHRSMIEMLE 351
Cdd:pfam07914 266 IKPVLVHGDLWQSNILWTLENDGKLKLKAIIDYQTVHMGNPAEDLVRLL-LSCLSgADRRAHWEELLEQYYETFTKALG 343
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
231-344 4.21e-03

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 38.94  E-value: 4.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508 231 LLQGADPGFGAAIERLREKYFKQPT------LLLERIRTSsFAEDQPDSHFATFLHGDYNRNNVLFHyGAEDKVDAIkaI 304
Cdd:COG3173 142 LADGRPEGLERQLARWRAQLRRALArtddlpALRERLAAW-LAANLPEWGPPVLVHGDLRPGNLLVD-PDDGRLTAV--I 217
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 19920508 305 DFQELRFSTTAIDLSFFMYMNTPSEGRKEIYADLLRKYHR 344
Cdd:COG3173 218 DWELATLGDPAADLAYLLLYWRLPDDLLGPRAAFLAAYEE 257
SrkA COG2334
Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal ...
224-355 6.81e-03

Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal transduction mechanisms]; Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 441905 [Multi-domain]  Cd Length: 297  Bit Score: 38.37  E-value: 6.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508 224 YDRQKEQLLQG--ADPGFGAAIERLREKYFKQPTLLLERIRTSsfaedqpdshfatFLHGDYNRNNVLFHygaEDKVDAI 301
Cdd:COG2334 138 WDELLERLLGPllPDPEDRALLEELLDRLEARLAPLLGALPRG-------------VIHGDLHPDNVLFD---GDGVSGL 201
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508 302 kaIDFQELRFSTTAIDLSFFMYMNTPSEGRKEIYADLLRKYHRSM------IEMLELVLR 355
Cdd:COG2334 202 --IDFDDAGYGPRLYDLAIALNGWADGPLDPARLAALLEGYRAVRplteaeLAALPPLLR 259
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
241-401 9.25e-03

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 36.68  E-value: 9.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508 241 AAIERLREKYFKQPTLLLERIRT-SSFAEDQPDSHfaTFLHGDYNRNNVLFhygaeDKVDAIKAIDFQELRFSTTAIDLS 319
Cdd:COG0510  15 ARLERYLALGPRDLPELLRRLEElERALAARPLPL--VLCHGDLHPGNFLV-----TDDGRLYLIDWEYAGLGDPAFDLA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920508 320 FFMYmntpsegrkeiyadllrkyhrsmiemlelvlrrnRNELTDDRVDQLLQEYSFERFNAH-FKRYAFYGPMVCMHFLP 398
Cdd:COG0510  88 ALLV----------------------------------EYGLSPEQAEELLEAYGFGRPTEElLRRLRAYRALADLLWAL 133

                ...
gi 19920508 399 WLL 401
Cdd:COG0510 134 WAL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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