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Conserved domains on  [gi|19526956|ref|NP_598510|]
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endoplasmic reticulum membrane protein complex subunit 7 precursor [Mus musculus]

Protein Classification

DUF2012 domain-containing protein( domain architecture ID 10559546)

DUF2012 domain-containing protein found in eukaryotic family of uncharacterized proteins; may be a subunit of ER membrane protein complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMC7_beta-sandw pfam09430
ER membrane protein complex subunit 7, beta-sandwich domain; This is the beta-sandwich domain ...
 56-167 1.07e-41

ER membrane protein complex subunit 7, beta-sandwich domain; This is the beta-sandwich domain found in ER membrane protein complex subunit 7 (EMC7), which is an integral membrane component of the EMC. EMC is widely conserved and involved in membrane protein biogenesis. It mediates the insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins in an energy-independent manner, both post-translational insertions of tail-anchored proteins and co-translational insertion of multipass membrane proteins. This entry includes UPF0620 protein C83.10 from S. pombe, an orthologue of animal EMC7. This domain is also found in nodal modulators, which have been identified as part of a protein complex that participates in the nodal signalling pathway during vertebrate development.


:

Pssm-ID: 430607  Cd Length: 121  Bit Score: 138.27  E-value: 1.07e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526956    56 KPQDWISAARVLVDGEEH--VGFLKTDGSFVVHDIPSGSYVVEVISPAYKFDPVRVDITSKGKMRARYVNYIKTSEVVRL 133
Cdd:pfam09430   1 NPNDLISNTRVTLDGGLHhfEVPVRRDGSFVFRDVPEGSYVLDVESPGYRFEPYRVDVTGKGKANAVKVTYVETYEVNPV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 19526956   134 -------PYPLQMKSSGPPSYFIKRESWGWTDFLMNPMVMM 167
Cdd:pfam09430  81 fgkgnleSYPLVIKPVGPHDYFEPREKFSITDLLKSPMVLM 121
 
Name Accession Description Interval E-value
EMC7_beta-sandw pfam09430
ER membrane protein complex subunit 7, beta-sandwich domain; This is the beta-sandwich domain ...
 56-167 1.07e-41

ER membrane protein complex subunit 7, beta-sandwich domain; This is the beta-sandwich domain found in ER membrane protein complex subunit 7 (EMC7), which is an integral membrane component of the EMC. EMC is widely conserved and involved in membrane protein biogenesis. It mediates the insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins in an energy-independent manner, both post-translational insertions of tail-anchored proteins and co-translational insertion of multipass membrane proteins. This entry includes UPF0620 protein C83.10 from S. pombe, an orthologue of animal EMC7. This domain is also found in nodal modulators, which have been identified as part of a protein complex that participates in the nodal signalling pathway during vertebrate development.


Pssm-ID: 430607  Cd Length: 121  Bit Score: 138.27  E-value: 1.07e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526956    56 KPQDWISAARVLVDGEEH--VGFLKTDGSFVVHDIPSGSYVVEVISPAYKFDPVRVDITSKGKMRARYVNYIKTSEVVRL 133
Cdd:pfam09430   1 NPNDLISNTRVTLDGGLHhfEVPVRRDGSFVFRDVPEGSYVLDVESPGYRFEPYRVDVTGKGKANAVKVTYVETYEVNPV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 19526956   134 -------PYPLQMKSSGPPSYFIKRESWGWTDFLMNPMVMM 167
Cdd:pfam09430  81 fgkgnleSYPLVIKPVGPHDYFEPREKFSITDLLKSPMVLM 121
 
Name Accession Description Interval E-value
EMC7_beta-sandw pfam09430
ER membrane protein complex subunit 7, beta-sandwich domain; This is the beta-sandwich domain ...
 56-167 1.07e-41

ER membrane protein complex subunit 7, beta-sandwich domain; This is the beta-sandwich domain found in ER membrane protein complex subunit 7 (EMC7), which is an integral membrane component of the EMC. EMC is widely conserved and involved in membrane protein biogenesis. It mediates the insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins in an energy-independent manner, both post-translational insertions of tail-anchored proteins and co-translational insertion of multipass membrane proteins. This entry includes UPF0620 protein C83.10 from S. pombe, an orthologue of animal EMC7. This domain is also found in nodal modulators, which have been identified as part of a protein complex that participates in the nodal signalling pathway during vertebrate development.


Pssm-ID: 430607  Cd Length: 121  Bit Score: 138.27  E-value: 1.07e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526956    56 KPQDWISAARVLVDGEEH--VGFLKTDGSFVVHDIPSGSYVVEVISPAYKFDPVRVDITSKGKMRARYVNYIKTSEVVRL 133
Cdd:pfam09430   1 NPNDLISNTRVTLDGGLHhfEVPVRRDGSFVFRDVPEGSYVLDVESPGYRFEPYRVDVTGKGKANAVKVTYVETYEVNPV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 19526956   134 -------PYPLQMKSSGPPSYFIKRESWGWTDFLMNPMVMM 167
Cdd:pfam09430  81 fgkgnleSYPLVIKPVGPHDYFEPREKFSITDLLKSPMVLM 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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