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Conserved domains on  [gi|18959228|ref|NP_579827|]
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trans-acting T-cell-specific transcription factor GATA-3 [Rattus norvegicus]

Protein Classification

GATA-type transcription factor( domain architecture ID 10078896)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 317-367 1.54e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.54e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 18959228 317 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNR 367
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 263-313 2.53e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.18  E-value: 2.53e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 18959228 263 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 313
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 317-367 1.54e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.54e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 18959228 317 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNR 367
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 263-313 2.53e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.18  E-value: 2.53e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 18959228 263 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 313
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
313-362 2.49e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.53  E-value: 2.49e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 18959228    313 RAGTSCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNI-NRPLTMKKEGI 362
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
260-307 6.51e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 68.60  E-value: 6.51e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 18959228    260 EGRECVNCGATSTPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 307
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 318-349 5.54e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 5.54e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 18959228   318 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLH 349
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKK 33
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 264-298 6.17e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 6.17e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 18959228   264 CVNCGATSTPLWRRDGTGHY-LCNACGLYHKMNGQN 298
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
207-342 5.42e-08

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 54.88  E-value: 5.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18959228 207 TLGGASSSAHHPITTYPPYVPEYSSGLFPPSSLLGGSPTgfgcksrpKARSSTEGRECVNCGATSTPLWRRD-----GTG 281
Cdd:COG5641 112 TSNAASPSTNYTDESNQQFSSYNTTLNPGGTSSLNPNNN--------QSDNSNQPHVCSNCKTTSTPLWRRAssessLPG 183

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18959228 282 HYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTT-TTLWRRNANGDPVCNAC 342
Cdd:COG5641 184 NNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSASKLTK 245
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 317-367 1.54e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.54e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 18959228 317 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNR 367
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 263-313 2.53e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.18  E-value: 2.53e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 18959228 263 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 313
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
313-362 2.49e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.53  E-value: 2.49e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 18959228    313 RAGTSCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNI-NRPLTMKKEGI 362
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
260-307 6.51e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 68.60  E-value: 6.51e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 18959228    260 EGRECVNCGATSTPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 307
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 318-349 5.54e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 5.54e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 18959228   318 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLH 349
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKK 33
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 264-298 6.17e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 6.17e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 18959228   264 CVNCGATSTPLWRRDGTGHY-LCNACGLYHKMNGQN 298
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
207-342 5.42e-08

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 54.88  E-value: 5.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18959228 207 TLGGASSSAHHPITTYPPYVPEYSSGLFPPSSLLGGSPTgfgcksrpKARSSTEGRECVNCGATSTPLWRRD-----GTG 281
Cdd:COG5641 112 TSNAASPSTNYTDESNQQFSSYNTTLNPGGTSSLNPNNN--------QSDNSNQPHVCSNCKTTSTPLWRRAssessLPG 183

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18959228 282 HYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTT-TTLWRRNANGDPVCNAC 342
Cdd:COG5641 184 NNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSASKLTK 245
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
266-414 1.62e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 53.34  E-value: 1.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18959228 266 NCGATSTPLWRR-DGTGHYLCNACGLYHKMNGQNRPLikPKRRLSAARRAGTSCANCQTTTTTLWRRNANGdpvCNACGL 344
Cdd:COG5641 303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKILSPPTT---SNSPGA 377

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18959228 345 YYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKvhdalEDFPKSSSFNPAALSRHMSSLSHISPFSHSS 414
Cdd:COG5641 378 QVKLPNQTRSTGATKKKITRRRMNSGKIPALSSS-----MKNPVPKEFSPLIPQSTESETPSQSKSSLTS 442
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
317-367 2.11e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.95  E-value: 2.11e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18959228 317 SCANCQTTTTTLWRR-----NANGDPVCNACGLYYKLHNINR-PLTMKKEGIQTRNR 367
Cdd:COG5641 160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSS 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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