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Conserved domains on  [gi|18859973|ref|NP_573176|]
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density regulated protein, isoform A [Drosophila melanogaster]

Protein Classification

SUI1 family translation initiation factor( domain architecture ID 960)

SUI1 family translation initiation factor is involved in the regulation of translation initiation, recognizing the start codon on mRNA by the ribosome and interacting with other components of the translation initiation complex to facilitate the assembly of the translation machinery.

Gene Ontology:  GO:0003723|GO:0003743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eIF1_SUI1_like super family cl00229
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 26-183 2.23e-45

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


The actual alignment was detected with superfamily member TIGR01159:

Pssm-ID: 469673  Cd Length: 173  Bit Score: 147.71  E-value: 2.23e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859973    26 PIQMKYCGHCTMPIEYCEYYPEYEKCKEWLELHMPDDFERLKIEEEAAAADGTDDDKKRQKRGGKGLLRV---------- 95
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVTIGEAQEEKGEKDLLGiqkaqeareg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859973    96 -KKKEDVPKRICVSRAARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSV----TGDDEIVIQGDVKDDLFDVIPE 170
Cdd:TIGR01159  81 gKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVsksvTGKEEIVIQGDVMDDIEDYIHE 160

                         170
                  ....*....|...
gi 18859973   171 KWAEIDEDVIEDL 183
Cdd:TIGR01159 161 KWPEVGDKDIKDL 173
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 26-183 2.23e-45

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 147.71  E-value: 2.23e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859973    26 PIQMKYCGHCTMPIEYCEYYPEYEKCKEWLELHMPDDFERLKIEEEAAAADGTDDDKKRQKRGGKGLLRV---------- 95
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVTIGEAQEEKGEKDLLGiqkaqeareg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859973    96 -KKKEDVPKRICVSRAARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSV----TGDDEIVIQGDVKDDLFDVIPE 170
Cdd:TIGR01159  81 gKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVsksvTGKEEIVIQGDVMDDIEDYIHE 160

                         170
                  ....*....|...
gi 18859973   171 KWAEIDEDVIEDL 183
Cdd:TIGR01159 161 KWPEVGDKDIKDL 173
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 103-184 1.31e-39

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 129.98  E-value: 1.31e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859973 103 KRICVSRAARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTGD----DEIVIQGDVKDDLFDVIPEKWAEIDED 178
Cdd:cd11607   1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASVTKGaegkDEIVIQGDVTDDIVDLILEKWPEIDED 80


                ....*.
gi 18859973 179 VIEDLG 184
Cdd:cd11607  81 NIEILG 86
SUI1 pfam01253
Translation initiation factor SUI1;
102-171 1.41e-17

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 73.24  E-value: 1.41e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18859973   102 PKRICVSRAARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTGD---DEIVIQGDVKDDLFDVIPEK 171
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVKDgggEEIQVQGDQRDKVAELLTEK 73
PRK00939 PRK00939
stress response translation initiation inhibitor YciH;
116-171 3.38e-05

stress response translation initiation inhibitor YciH;


Pssm-ID: 179173  Cd Length: 99  Bit Score: 41.06  E-value: 3.38e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 18859973  116 KSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTgDDEIVIQGDVKDDLFDVIPEK 171
Cdd:PRK00939  37 KEVTIIEGIDPKDIDLKELAKKLKSKLACGGTVK-DGRIELQGDHRERVKELLIKM 91
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 26-183 2.23e-45

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 147.71  E-value: 2.23e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859973    26 PIQMKYCGHCTMPIEYCEYYPEYEKCKEWLELHMPDDFERLKIEEEAAAADGTDDDKKRQKRGGKGLLRV---------- 95
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVTIGEAQEEKGEKDLLGiqkaqeareg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859973    96 -KKKEDVPKRICVSRAARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSV----TGDDEIVIQGDVKDDLFDVIPE 170
Cdd:TIGR01159  81 gKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVsksvTGKEEIVIQGDVMDDIEDYIHE 160

                         170
                  ....*....|...
gi 18859973   171 KWAEIDEDVIEDL 183
Cdd:TIGR01159 161 KWPEVGDKDIKDL 173
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 103-184 1.31e-39

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 129.98  E-value: 1.31e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859973 103 KRICVSRAARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTGD----DEIVIQGDVKDDLFDVIPEKWAEIDED 178
Cdd:cd11607   1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASVTKGaegkDEIVIQGDVTDDIVDLILEKWPEIDED 80


                ....*.
gi 18859973 179 VIEDLG 184
Cdd:cd11607  81 NIEILG 86
SUI1 pfam01253
Translation initiation factor SUI1;
102-171 1.41e-17

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 73.24  E-value: 1.41e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18859973   102 PKRICVSRAARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTGD---DEIVIQGDVKDDLFDVIPEK 171
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVKDgggEEIQVQGDQRDKVAELLTEK 73
eIF1_SUI1_like cd00474
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 105-176 1.57e-12

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


Pssm-ID: 211317  Cd Length: 78  Bit Score: 60.13  E-value: 1.57e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18859973 105 ICVSRAARGKKKSVTVVTGLSTFdIDLKVAAKFFGTKFACGSSVTGD-DEIVIQGDVKDDLFDVIPEKWAEID 176
Cdd:cd00474   2 IHIKVEQRSGGKKVTKVEGLPAY-IDLRKLADELKKKLGCGGSVEGEkMEIEIQGDHTDQIIVALEEKGIDKD 73
YciH_like cd11567
Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic ...
 111-164 1.85e-07

Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. The function of non-eukaryotic family members is unclear. Escherichia coli YciH is a non-essential protein and was reported to be able to perform some of the functions of IF3 in prokaryotic initiation.


Pssm-ID: 211319  Cd Length: 76  Bit Score: 46.71  E-value: 1.85e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 18859973 111 ARGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTgDDEIVIQGDVKDDL 164
Cdd:cd11567  10 RGRGGKTVTVIEGLPLSEEDLKELAKELKKKCGCGGTVK-DGEIELQGDHREKI 62
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 112-172 6.51e-07

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 45.25  E-value: 6.51e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18859973 112 RGKKKSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVT------GDDEIVIQGDVKDDLFDVIPEKW 172
Cdd:cd11608   9 RQGNKKVTLISGLESFGIDPEEFAKELQKKCAASTSVSplpgkkKGVEVQVQGNQVKFVAKLLTEKY 75
PRK00939 PRK00939
stress response translation initiation inhibitor YciH;
116-171 3.38e-05

stress response translation initiation inhibitor YciH;


Pssm-ID: 179173  Cd Length: 99  Bit Score: 41.06  E-value: 3.38e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 18859973  116 KSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTgDDEIVIQGDVKDDLFDVIPEK 171
Cdd:PRK00939  37 KEVTIIEGIDPKDIDLKELAKKLKSKLACGGTVK-DGRIELQGDHRERVKELLIKM 91
eIF1_SUI1 cd11566
Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important ...
 112-159 6.22e-05

Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown.


Pssm-ID: 211318  Cd Length: 84  Bit Score: 39.83  E-value: 6.22e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 18859973 112 RGKKKSVTVVTGLSTfDIDLKVAAKFFGTKFACGSSVTGDDE----IVIQGD 159
Cdd:cd11566  10 RNGRKTLTTVQGLPE-EFDLKKILKAFKKEFACNGTVVEDPEygevIQLQGD 60
PRK07451 PRK07451
translation initiation factor;
104-168 1.60e-04

translation initiation factor;


Pssm-ID: 236021  Cd Length: 115  Bit Score: 39.76  E-value: 1.60e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18859973  104 RICVSRAARgKKKSVTVVTGLSTFDIDLKVAAKffGTKFACGSSVT-GDDEIVIQGDVKDDLFDVI 168
Cdd:PRK07451  41 RVQATRSGR-KGKTVTVITGFQHKPETLAKLLK--QLKTQCGSGGTvKDNTIEIQGDHRQKILEIL 103
PRK09019 PRK09019
stress response translation initiation inhibitor YciH;
96-164 9.68e-04

stress response translation initiation inhibitor YciH;


Pssm-ID: 181613  Cd Length: 108  Bit Score: 37.27  E-value: 9.68e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18859973   96 KKKEDVPK-----RIcvSRAARGKK-KSVTVVTGLSTFDIDLKVAAKFFGTKFACGSSVTgDDEIVIQGDVKDDL 164
Cdd:PRK09019  21 KAKPERPKgdgivRI--QRQTSGRKgKGVCLITGLDLDDAELKKLAAELKKKCGCGGAVK-DGVIEIQGDKRDLL 92
PRK06824 PRK06824
translation initiation factor Sui1; Validated
 107-166 7.61e-03

translation initiation factor Sui1; Validated


Pssm-ID: 168689  Cd Length: 118  Bit Score: 35.05  E-value: 7.61e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18859973  107 VSRAARGKK-KSVTVVTGLSTFDIDLKVAAKFFgtKFACGSSVTGDDEIV-IQGDVKDDLFD 166
Cdd:PRK06824  45 VRRETKGRGgKTVTVITGVPLAEDALKELAKEL--KRRCGTGGTLKDGVIeIQGDHVELLLA 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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