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Conserved domains on  [gi|24642269|ref|NP_573065|]
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uncharacterized protein Dmel_CG8944 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 259-344 8.23e-19

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


:

Pssm-ID: 463144  Cd Length: 84  Bit Score: 81.56  E-value: 8.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269   259 LIHSYQRNPFLWDHGNAQFRDRVKRARFLDWIVLEFKSRFNIslakDAITRKWDNLRTVYKRECNRMALE--KTNISTLW 336
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSDVPV----EDCKKRWKNLRDQYRRELRRKRTNsgELYKSRWY 76


                  ....*...
gi 24642269   337 YFKELHFL 344
Cdd:pfam10545  77 YYEELSFL 84
MADF smart00595
subfamily of SANT domain;
379-472 2.83e-17

subfamily of SANT domain;


:

Pssm-ID: 214738  Cd Length: 89  Bit Score: 77.40  E-value: 2.83e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269    379 KLLSMVKRYQCFYNRFDPDYRSKERRGEGLHQMAIELQQlidvTTIQISKRISQLRFDYSKQKMeRLNSERLGKKFIANY 458
Cdd:smart00595   1 RLIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELGL----SVEECKKRWKNLRDRYRRELK-RLQNGKSGGGKKSKW 75

                           90
                   ....*....|....
gi 24642269    459 LYYDQMHFMDDDIP 472
Cdd:smart00595  76 EYFDRLSFLRPVIR 89
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
666-734 3.21e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 3.21e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24642269 666 CDYPQCNKSFVARNSLFEHLKQHYS--NEEFKCDICGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQA 734
Cdd:COG5048 389 TLSNSCIRNFKRDSNLSLHIITHLSfrPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
 
Name Accession Description Interval E-value
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 259-344 8.23e-19

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 81.56  E-value: 8.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269   259 LIHSYQRNPFLWDHGNAQFRDRVKRARFLDWIVLEFKSRFNIslakDAITRKWDNLRTVYKRECNRMALE--KTNISTLW 336
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSDVPV----EDCKKRWKNLRDQYRRELRRKRTNsgELYKSRWY 76


                  ....*...
gi 24642269   337 YFKELHFL 344
Cdd:pfam10545  77 YYEELSFL 84
MADF smart00595
subfamily of SANT domain;
379-472 2.83e-17

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 77.40  E-value: 2.83e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269    379 KLLSMVKRYQCFYNRFDPDYRSKERRGEGLHQMAIELQQlidvTTIQISKRISQLRFDYSKQKMeRLNSERLGKKFIANY 458
Cdd:smart00595   1 RLIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELGL----SVEECKKRWKNLRDRYRRELK-RLQNGKSGGGKKSKW 75

                           90
                   ....*....|....
gi 24642269    459 LYYDQMHFMDDDIP 472
Cdd:smart00595  76 EYFDRLSFLRPVIR 89
MADF smart00595
subfamily of SANT domain;
259-348 1.09e-15

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 72.78  E-value: 1.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269    259 LIHSYQRNPFLWDHGNAQFRDRVKRARFLDWIVLEFKSRfnislaKDAITRKWDNLRTVYKRECNRMALEKT--NISTLW 336
Cdd:smart00595   2 LIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELGLS------VEECKKRWKNLRDRYRRELKRLQNGKSggGKKSKW 75

                           90
                   ....*....|...
gi 24642269    337 -YFKELHFLNEVY 348
Cdd:smart00595  76 eYFDRLSFLRPVI 88
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 380-467 2.58e-09

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 54.60  E-value: 2.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269   380 LLSMVKRYQCFYNRFDPDYRSKERRGEGLHQMAIELQQLIDVTtiQISKRISQLRFDYSKQKmeRLNSERLGKKFIANYL 459
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSDVPVE--DCKKRWKNLRDQYRREL--RRKRTNSGELYKSRWY 76


                  ....*...
gi 24642269   460 YYDQMHFM 467
Cdd:pfam10545  77 YYEELSFL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
666-734 3.21e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 3.21e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24642269 666 CDYPQCNKSFVARNSLFEHLKQHYS--NEEFKCDICGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQA 734
Cdd:COG5048 389 TLSNSCIRNFKRDSNLSLHIITHLSfrPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 694-716 5.57e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 5.57e-04
                          10        20
                  ....*....|....*....|...
gi 24642269   694 FKCDICGKTFKSTKNLQNHKQIH 716
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 665-716 1.37e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.37e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 24642269 665 KCDYpqCNKSFVARNSLFEHLKQHYsneeFKCDICGKTFKSTKNLQNH-KQIH 716
Cdd:cd20908   3 WCYY--CDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 259-344 8.23e-19

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 81.56  E-value: 8.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269   259 LIHSYQRNPFLWDHGNAQFRDRVKRARFLDWIVLEFKSRFNIslakDAITRKWDNLRTVYKRECNRMALE--KTNISTLW 336
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSDVPV----EDCKKRWKNLRDQYRRELRRKRTNsgELYKSRWY 76


                  ....*...
gi 24642269   337 YFKELHFL 344
Cdd:pfam10545  77 YYEELSFL 84
MADF smart00595
subfamily of SANT domain;
379-472 2.83e-17

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 77.40  E-value: 2.83e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269    379 KLLSMVKRYQCFYNRFDPDYRSKERRGEGLHQMAIELQQlidvTTIQISKRISQLRFDYSKQKMeRLNSERLGKKFIANY 458
Cdd:smart00595   1 RLIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELGL----SVEECKKRWKNLRDRYRRELK-RLQNGKSGGGKKSKW 75

                           90
                   ....*....|....
gi 24642269    459 LYYDQMHFMDDDIP 472
Cdd:smart00595  76 EYFDRLSFLRPVIR 89
MADF smart00595
subfamily of SANT domain;
259-348 1.09e-15

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 72.78  E-value: 1.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269    259 LIHSYQRNPFLWDHGNAQFRDRVKRARFLDWIVLEFKSRfnislaKDAITRKWDNLRTVYKRECNRMALEKT--NISTLW 336
Cdd:smart00595   2 LIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELGLS------VEECKKRWKNLRDRYRRELKRLQNGKSggGKKSKW 75

                           90
                   ....*....|...
gi 24642269    337 -YFKELHFLNEVY 348
Cdd:smart00595  76 eYFDRLSFLRPVI 88
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 380-467 2.58e-09

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 54.60  E-value: 2.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269   380 LLSMVKRYQCFYNRFDPDYRSKERRGEGLHQMAIELQQLIDVTtiQISKRISQLRFDYSKQKmeRLNSERLGKKFIANYL 459
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSDVPVE--DCKKRWKNLRDQYRREL--RRKRTNSGELYKSRWY 76


                  ....*...
gi 24642269   460 YYDQMHFM 467
Cdd:pfam10545  77 YYEELSFL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
666-734 3.21e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 3.21e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24642269 666 CDYPQCNKSFVARNSLFEHLKQHYS--NEEFKCDICGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQA 734
Cdd:COG5048 389 TLSNSCIRNFKRDSNLSLHIITHLSfrPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 694-716 5.57e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 5.57e-04
                          10        20
                  ....*....|....*....|...
gi 24642269   694 FKCDICGKTFKSTKNLQNHKQIH 716
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 666-740 5.76e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 39.71  E-value: 5.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269   666 CDYPQCNKSFVARNSLFEHLKQH------YSNEEFKCDI--CGKTFKSTKNLQNHKQIHDKIKRYV-CQICGSAFAQAAG 736
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFkCENCLLRFRTHRS 81


                  ....
gi 24642269   737 LYLH 740
Cdd:pfam15909  82 LFKH 85
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 648-715 9.47e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 39.32  E-value: 9.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24642269   648 HLNAHRIVHQDERERCYKCDYPQCNKSFVARNSLFEHLKQHYS-NEEFKCDICGKTFKSTKNLQNHKQI 715
Cdd:pfam15909  20 HLRTHCPPTQSLEGKLFRCSALSCTETFPSMQELVAHSKLHYKpNRYFKCENCLLRFRTHRSLFKHLHV 88
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 661-744 1.02e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269 661 ERCYKCDYPQCNKSFVARNSLFEHLKQHYsneefkcdiCGKTFKSTKNLQNHKQIHDKIKRYVCQICGSAFAQAAGLYLH 740
Cdd:COG5189 347 GKPYKCPVEGCNKKYKNQNGLKYHMLHGH---------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                ....
gi 24642269 741 kRRH 744
Cdd:COG5189 418 -RKH 420
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
632-749 1.36e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642269 632 KPYGCDVCRRSFATPGHLNAHR--IVHQDERERCYKCDYPQCNKSFVARNSLFEHLKQHYSNEEFKCDICGKTFKSTKNL 709
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 24642269 710 -------QNHKQIHDKIKRYVC--QICGSAFAQAAGLYLHKRRHNRPNG 749
Cdd:COG5048 368 nneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 665-716 1.37e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.37e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 24642269 665 KCDYpqCNKSFVARNSLFEHLKQHYsneeFKCDICGKTFKSTKNLQNH-KQIH 716
Cdd:cd20908   3 WCYY--CDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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