NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24642125|ref|NP_573012|]
View 

protein phosphatase Y regulator 1 [Drosophila melanogaster]

Protein Classification

HABP4_PAI-RBP1 domain-containing protein( domain architecture ID 10521441)

HABP4_PAI-RBP1 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 96-180 1.05e-11

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


:

Pssm-ID: 461421  Cd Length: 108  Bit Score: 60.46  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642125    96 GDRLFDRRSGSKRtgvKAVEKRNGAGAHNWGSIQQEIDLrQRTNLRTFEGMKLPKVSSFVYEYDSSEETE---------- 165
Cdd:pfam04774   1 GKREFDRHSGTGR---GPEEKRDGAGRHNWGTVKDEIEA-PEEEEAENEMEKNNDAEKEAGEEETDENEEaaaaeeeeke 76

                          90       100
                  ....*....|....*....|
gi 24642125   166 -----QYTLDEWRAMQAQKK 180
Cdd:pfam04774  77 pnedkEMTLDEYKKVQEEKR 96
 
Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 96-180 1.05e-11

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


Pssm-ID: 461421  Cd Length: 108  Bit Score: 60.46  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642125    96 GDRLFDRRSGSKRtgvKAVEKRNGAGAHNWGSIQQEIDLrQRTNLRTFEGMKLPKVSSFVYEYDSSEETE---------- 165
Cdd:pfam04774   1 GKREFDRHSGTGR---GPEEKRDGAGRHNWGTVKDEIEA-PEEEEAENEMEKNNDAEKEAGEEETDENEEaaaaeeeeke 76

                          90       100
                  ....*....|....*....|
gi 24642125   166 -----QYTLDEWRAMQAQKK 180
Cdd:pfam04774  77 pnedkEMTLDEYKKVQEEKR 96
 
Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 96-180 1.05e-11

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


Pssm-ID: 461421  Cd Length: 108  Bit Score: 60.46  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642125    96 GDRLFDRRSGSKRtgvKAVEKRNGAGAHNWGSIQQEIDLrQRTNLRTFEGMKLPKVSSFVYEYDSSEETE---------- 165
Cdd:pfam04774   1 GKREFDRHSGTGR---GPEEKRDGAGRHNWGTVKDEIEA-PEEEEAENEMEKNNDAEKEAGEEETDENEEaaaaeeeeke 76

                          90       100
                  ....*....|....*....|
gi 24642125   166 -----QYTLDEWRAMQAQKK 180
Cdd:pfam04774  77 pnedkEMTLDEYKKVQEEKR 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH