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Conserved domains on  [gi|24640390|ref|NP_572401|]
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hira [Drosophila melanogaster]

Protein Classification

HIRA family protein( domain architecture ID 10078067)

HIRA family protein similar to Drosophila melanogaster Protein HIRA homolog required for the periodic repression of histone gene transcription during the cell cycle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-349 3.52e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 170.59  E-value: 3.52e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   14 KQIFSVDIHKDCTKFATGGQGsdcGRVVIWNLlpvlsdkaefdaDVPKMLCQMDQHLACVNCVRWSQNGQNLASGSDDKL 93
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGD---GTIKVWDL------------ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   94 IMIWRKSAGssgvfgtggmqknheswKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPhSVATLKGHTG 173
Cdd:cd00200   75 IRLWDLETG-----------------ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK-CLTTLRGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  174 LVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITepfeecggtTH---ILRLSWSPDGQYLVSAhamnGGGPTAQI 250
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT---------GHtgeVNSVAFSPDGEKLLSS----SSDGTIKL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  251 IEREGWKCDKDFVGHRKAVTCVRFhnsilsrqendgSPSKPLqyccLAVGSRDRSLSVWMTALQRPMVVIHElFNASILD 330
Cdd:cd00200  204 WDLSTGKCLGTLRGHENGVNSVAF------------SPDGYL----LASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTS 266

                        330
                 ....*....|....*....
gi 24640390  331 LTWGPQECLLMACSVDGSI 349
Cdd:cd00200  267 LAWSPDGKRLASGSADGTI 285
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 630-828 2.15e-42

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


:

Pssm-ID: 462211  Cd Length: 221  Bit Score: 154.32  E-value: 2.15e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390    630 GCPVFPAISLTSSAVHCAFSpdNSLVGVLTECGLLRIWDIAKKVVSL-AAGCLELLN----------KHGTAAQFSVTNQ 698
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECS--GSYLLAVTSVGLLYVWDIKKQKALLpPVSLAPLLDsssrysdkltRAPTITSASLTSN 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390    699 GMPLIGFPSGNSYSYSTSLQSWLVLATK-DAIMYHGIRGT-LPRDMDQMQQKFPLLSMQASSQNYFSFTGSMELRHSESW 776
Cdd:pfam07569   79 GVPIVTLSNGDGYLYDKSLETWLRISDSwWALGSQYWDSTgSSRSSSQSSAAGILSFLERKTNEELLRKGRGRLLQRLAK 158

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24640390    777 -----------QQCAKIRFIENQIKLCEALQSLDELQHWHKMLTFQLATHGSEKRMRVFLDDL 828
Cdd:pfam07569  159 tllmkegfenfETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
HIRA_B pfam09453
HIRA B motif; The HirA B (Histone regulatory homolog A binding) motif is the essential binding ...
 424-442 1.23e-05

HIRA B motif; The HirA B (Histone regulatory homolog A binding) motif is the essential binding interface between HIRA pfam07569 and ASF1a, of approx. 40 residues. It forms an antiparallel beta-hairpin that binds perpendicular to the strands of the beta-sandwich of ASF1a N-terminal core domain, via beta-sheet, salt bridge and van der Waals interactions. The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The yeast CAF1B proteins which bind H3 also carry this motif at their very C-terminus.


:

Pssm-ID: 462802  Cd Length: 22  Bit Score: 42.89  E-value: 1.23e-05
                           10
                   ....*....|....*....
gi 24640390    424 QTETRTKDGKRRITPMFIP 442
Cdd:pfam09453    1 QKVTITKDGKKRVAPTLIS 19
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-349 3.52e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 170.59  E-value: 3.52e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   14 KQIFSVDIHKDCTKFATGGQGsdcGRVVIWNLlpvlsdkaefdaDVPKMLCQMDQHLACVNCVRWSQNGQNLASGSDDKL 93
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGD---GTIKVWDL------------ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   94 IMIWRKSAGssgvfgtggmqknheswKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPhSVATLKGHTG 173
Cdd:cd00200   75 IRLWDLETG-----------------ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK-CLTTLRGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  174 LVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITepfeecggtTH---ILRLSWSPDGQYLVSAhamnGGGPTAQI 250
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT---------GHtgeVNSVAFSPDGEKLLSS----SSDGTIKL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  251 IEREGWKCDKDFVGHRKAVTCVRFhnsilsrqendgSPSKPLqyccLAVGSRDRSLSVWMTALQRPMVVIHElFNASILD 330
Cdd:cd00200  204 WDLSTGKCLGTLRGHENGVNSVAF------------SPDGYL----LASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTS 266

                        330
                 ....*....|....*....
gi 24640390  331 LTWGPQECLLMACSVDGSI 349
Cdd:cd00200  267 LAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
2-309 8.13e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 8.13e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390    2 RLLKPAWVHHDdkQIFSVDIHKDCTKFATGGQGsdcGRVVIWnllpvlsdkaefDADVPKMLCQMDQHLACVNCVRWSQN 81
Cdd:COG2319  153 KLLRTLTGHSG--AVTSVAFSPDGKLLASGSDD---GTVRLW------------DLATGKLLRTLTGHTGAVRSVAFSPD 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   82 GQNLASGSDDKLIMIWrksagssgvfgtggmqkNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAf 161
Cdd:COG2319  216 GKLLASGSADGTVRLW-----------------DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT- 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  162 PHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITepfeecGGTTHILRLSWSPDGQYLVSAham 241
Cdd:COG2319  278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT------GHTGAVRSVAFSPDGKTLASG--- 348

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24640390  242 nGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHnsilsrqeNDGSpskplqycCLAVGSRDRSLSVW 309
Cdd:COG2319  349 -SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS--------PDGR--------TLASGSADGTVRLW 399
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 630-828 2.15e-42

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 154.32  E-value: 2.15e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390    630 GCPVFPAISLTSSAVHCAFSpdNSLVGVLTECGLLRIWDIAKKVVSL-AAGCLELLN----------KHGTAAQFSVTNQ 698
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECS--GSYLLAVTSVGLLYVWDIKKQKALLpPVSLAPLLDsssrysdkltRAPTITSASLTSN 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390    699 GMPLIGFPSGNSYSYSTSLQSWLVLATK-DAIMYHGIRGT-LPRDMDQMQQKFPLLSMQASSQNYFSFTGSMELRHSESW 776
Cdd:pfam07569   79 GVPIVTLSNGDGYLYDKSLETWLRISDSwWALGSQYWDSTgSSRSSSQSSAAGILSFLERKTNEELLRKGRGRLLQRLAK 158

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24640390    777 -----------QQCAKIRFIENQIKLCEALQSLDELQHWHKMLTFQLATHGSEKRMRVFLDDL 828
Cdd:pfam07569  159 tllmkegfenfETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 118-157 5.09e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.48  E-value: 5.09e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 24640390     118 SWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWD 157
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
119-157 4.99e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.43  E-value: 4.99e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24640390    119 WKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWD 157
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 125-213 7.93e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 53.03  E-value: 7.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   125 LRGHDGDVLDLAWSP-NDVYLASCSIDNTVIIWDAQAFPHSV-------ATLKGHTGLVKGVSWDPLGRF-LASQSDDRS 195
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNPMNYYiMCSSGFDSF 149

                          90
                  ....*....|....*...
gi 24640390   196 IKIWNTMNWSLSHTITEP 213
Cdd:PTZ00420  150 VNIWDIENEKRAFQINMP 167
HIRA_B pfam09453
HIRA B motif; The HirA B (Histone regulatory homolog A binding) motif is the essential binding ...
 424-442 1.23e-05

HIRA B motif; The HirA B (Histone regulatory homolog A binding) motif is the essential binding interface between HIRA pfam07569 and ASF1a, of approx. 40 residues. It forms an antiparallel beta-hairpin that binds perpendicular to the strands of the beta-sandwich of ASF1a N-terminal core domain, via beta-sheet, salt bridge and van der Waals interactions. The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The yeast CAF1B proteins which bind H3 also carry this motif at their very C-terminus.


Pssm-ID: 462802  Cd Length: 22  Bit Score: 42.89  E-value: 1.23e-05
                           10
                   ....*....|....*....
gi 24640390    424 QTETRTKDGKRRITPMFIP 442
Cdd:pfam09453    1 QKVTITKDGKKRVAPTLIS 19
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-349 3.52e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 170.59  E-value: 3.52e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   14 KQIFSVDIHKDCTKFATGGQGsdcGRVVIWNLlpvlsdkaefdaDVPKMLCQMDQHLACVNCVRWSQNGQNLASGSDDKL 93
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGD---GTIKVWDL------------ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   94 IMIWRKSAGssgvfgtggmqknheswKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPhSVATLKGHTG 173
Cdd:cd00200   75 IRLWDLETG-----------------ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK-CLTTLRGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  174 LVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITepfeecggtTH---ILRLSWSPDGQYLVSAhamnGGGPTAQI 250
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT---------GHtgeVNSVAFSPDGEKLLSS----SSDGTIKL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  251 IEREGWKCDKDFVGHRKAVTCVRFhnsilsrqendgSPSKPLqyccLAVGSRDRSLSVWMTALQRPMVVIHElFNASILD 330
Cdd:cd00200  204 WDLSTGKCLGTLRGHENGVNSVAF------------SPDGYL----LASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTS 266

                        330
                 ....*....|....*....
gi 24640390  331 LTWGPQECLLMACSVDGSI 349
Cdd:cd00200  267 LAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
2-309 8.13e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 8.13e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390    2 RLLKPAWVHHDdkQIFSVDIHKDCTKFATGGQGsdcGRVVIWnllpvlsdkaefDADVPKMLCQMDQHLACVNCVRWSQN 81
Cdd:COG2319  153 KLLRTLTGHSG--AVTSVAFSPDGKLLASGSDD---GTVRLW------------DLATGKLLRTLTGHTGAVRSVAFSPD 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   82 GQNLASGSDDKLIMIWrksagssgvfgtggmqkNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAf 161
Cdd:COG2319  216 GKLLASGSADGTVRLW-----------------DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT- 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  162 PHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITepfeecGGTTHILRLSWSPDGQYLVSAham 241
Cdd:COG2319  278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT------GHTGAVRSVAFSPDGKTLASG--- 348

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24640390  242 nGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHnsilsrqeNDGSpskplqycCLAVGSRDRSLSVW 309
Cdd:COG2319  349 -SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS--------PDGR--------TLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
2-349 4.01e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.17  E-value: 4.01e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390    2 RLLKPAWVHHDdkQIFSVDIHKDCTKFATGGQGsdcGRVVIWnllpvlsdkaefDADVPKMLCQMDQHLACVNCVRWSQN 81
Cdd:COG2319   69 ALLATLLGHTA--AVLSVAFSPDGRLLASASAD---GTVRLW------------DLATGLLLRTLTGHTGAVRSVAFSPD 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   82 GQNLASGSDDKLIMIWrksagssgvfgtggmqkNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAF 161
Cdd:COG2319  132 GKTLASGSADGTVRLW-----------------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  162 PHsVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITepfeecGGTTHILRLSWSPDGQYLVSAham 241
Cdd:COG2319  195 KL-LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT------GHSGSVRSVAFSPDGRLLASG--- 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  242 nGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHnsilsrqeNDGspskplQYccLAVGSRDRSLSVWMTALQRPmVVIH 321
Cdd:COG2319  265 -SADGTVRLWDLATGELLRTLTGHSGGVNSVAFS--------PDG------KL--LASGSDDGTVRLWDLATGKL-LRTL 326

                        330       340
                 ....*....|....*....|....*...
gi 24640390  322 ELFNASILDLTWGPQECLLMACSVDGSI 349
Cdd:COG2319  327 TGHTGAVRSVAFSPDGKTLASGSDDGTV 354
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 630-828 2.15e-42

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 154.32  E-value: 2.15e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390    630 GCPVFPAISLTSSAVHCAFSpdNSLVGVLTECGLLRIWDIAKKVVSL-AAGCLELLN----------KHGTAAQFSVTNQ 698
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECS--GSYLLAVTSVGLLYVWDIKKQKALLpPVSLAPLLDsssrysdkltRAPTITSASLTSN 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390    699 GMPLIGFPSGNSYSYSTSLQSWLVLATK-DAIMYHGIRGT-LPRDMDQMQQKFPLLSMQASSQNYFSFTGSMELRHSESW 776
Cdd:pfam07569   79 GVPIVTLSNGDGYLYDKSLETWLRISDSwWALGSQYWDSTgSSRSSSQSSAAGILSFLERKTNEELLRKGRGRLLQRLAK 158

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24640390    777 -----------QQCAKIRFIENQIKLCEALQSLDELQHWHKMLTFQLATHGSEKRMRVFLDDL 828
Cdd:pfam07569  159 tllmkegfenfETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 69-349 1.12e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 151.72  E-value: 1.12e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   69 HLACVNCVRWSQNGQNLASGSDDKLIMIWRKSAGSsgvfgtggmqknheswkCFYTLRGHDGDVLDLAWSPNDVYLASCS 148
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE-----------------LLRTLKGHTGPVRDVAASADGTYLASGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  149 IDNTVIIWDAQAfPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITepfeecGGTTHILRLSW 228
Cdd:cd00200   71 SDKTIRLWDLET-GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR------GHTDWVNSVAF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  229 SPDGQYLVSAHAmNGggpTAQIIEREGWKCDKDFVGHRKAVTCVRFHnsilsrqeNDGSPskplqyccLAVGSRDRSLSV 308
Cdd:cd00200  144 SPDGTFVASSSQ-DG---TIKLWDLRTGKCVATLTGHTGEVNSVAFS--------PDGEK--------LLSSSSDGTIKL 203

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 24640390  309 WMTALQRPMVVIHElFNASILDLTWGPQECLLMACSVDGSI 349
Cdd:cd00200  204 WDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTI 243
WD40 COG2319
WD40 repeat [General function prediction only];
10-201 2.95e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 2.95e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   10 HHDDKQIFSVDIHKDCTKFATGGQGsdcGRVVIWnllpvlsdkaefDADVPKMLCQMDQHLACVNCVRWSQNGQNLASGS 89
Cdd:COG2319  243 TGHSGSVRSVAFSPDGRLLASGSAD---GTVRLW------------DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   90 DDKLIMIWrksagssgvfgtggmqkNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAfPHSVATLK 169
Cdd:COG2319  308 DDGTVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT-GELLRTLT 369

                        170       180       190
                 ....*....|....*....|....*....|..
gi 24640390  170 GHTGLVKGVSWDPLGRFLASQSDDRSIKIWNT 201
Cdd:COG2319  370 GHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
69-349 1.10e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 1.10e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   69 HLACVNCVRWSQNGQNLASGSDDKLIMIWRKSAGssgvfgtggmqknheswKCFYTLRGHDGDVLDLAWSPNDVYLASCS 148
Cdd:COG2319   35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-----------------ALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  149 IDNTVIIWDAQAfPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITepfeecGGTTHILRLSW 228
Cdd:COG2319   98 ADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT------GHSGAVTSVAF 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  229 SPDGQYLVSAhamnGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHnsilsrqeNDGspskplQYccLAVGSRDRSLSV 308
Cdd:COG2319  171 SPDGKLLASG----SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS--------PDG------KL--LASGSADGTVRL 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 24640390  309 WMTALQRPMVVIHElFNASILDLTWGPQECLLMACSVDGSI 349
Cdd:COG2319  231 WDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTV 270
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 124-349 5.02e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.98  E-value: 5.02e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  124 TLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQaFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMN 203
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  204 WSLSHTITepfeecGGTTHILRLSWSPDGQYLVSAhamnGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFhnsilsrqe 283
Cdd:cd00200   83 GECVRTLT------GHTSYVSSVAFSPDGRILSSS----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF--------- 143

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24640390  284 ndgSPSKPLqyccLAVGSRDRSLSVWMTALQRPMVVIHElFNASILDLTWGPQECLLMACSVDGSI 349
Cdd:cd00200  144 ---SPDGTF----VASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTI 201
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-200 7.65e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 7.65e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390    8 WVHHDdKQIFSVDIHKDCTKFATGGqgSDcGRVVIWNLlpvlsdkaefdaDVPKMLCQMDQHLACVNCVRWSQNGQNLAS 87
Cdd:cd00200   89 LTGHT-SYVSSVAFSPDGRILSSSS--RD-KTIKVWDV------------ETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   88 GSDDKLIMIWRKSAGS--------------------SGVFGTGGMQK-----NHESWKCFYTLRGHDGDVLDLAWSPNDV 142
Cdd:cd00200  153 SSQDGTIKLWDLRTGKcvatltghtgevnsvafspdGEKLLSSSSDGtiklwDLSTGKCLGTLRGHENGVNSVAFSPDGY 232

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 24640390  143 YLASCSIDNTVIIWDAQAFpHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWN 200
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
124-349 6.05e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.44  E-value: 6.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  124 TLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAfPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMN 203
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA-GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  204 WSLSHTITepfeecGGTTHILRLSWSPDGQYLVSAhamnGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHnsilsrqe 283
Cdd:COG2319  110 GLLLRTLT------GHTGAVRSVAFSPDGKTLASG----SADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-------- 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24640390  284 NDGSPskplqyccLAVGSRDRSLSVWMTALQRPmvvIHEL--FNASILDLTWGPQECLLMACSVDGSI 349
Cdd:COG2319  172 PDGKL--------LASGSDDGTVRLWDLATGKL---LRTLtgHTGAVRSVAFSPDGKLLASGSADGTV 228
WD40 COG2319
WD40 repeat [General function prediction only];
10-159 2.40e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.81  E-value: 2.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   10 HHDDkQIFSVDIHKDCTKFATGGQGsdcGRVVIWnllpvlsdkaefDADVPKMLCQMDQHLACVNCVRWSQNGQNLASGS 89
Cdd:COG2319  286 GHSG-GVNSVAFSPDGKLLASGSDD---GTVRLW------------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   90 DDKLIMIWrksagssgvfgtggmqkNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQ 159
Cdd:COG2319  350 DDGTVRLW-----------------DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 118-157 5.09e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.48  E-value: 5.09e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 24640390     118 SWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWD 157
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
119-157 4.99e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.43  E-value: 4.99e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24640390    119 WKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWD 157
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
136-349 2.04e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 2.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  136 AWSPNDVYLASCSIDNTVIIWDAQAfPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITepfe 215
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAAL-GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL---- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  216 ecGGTTHILRLSWSPDGQYLVSAhamnGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHnsilsrqeNDGSPskplqyc 295
Cdd:COG2319   76 --GHTAAVLSVAFSPDGRLLASA----SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--------PDGKT------- 134

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 24640390  296 cLAVGSRDRSLSVWMTALQRPMVVIHElFNASILDLTWGPQECLLMACSVDGSI 349
Cdd:COG2319  135 -LASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTV 186
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 165-200 2.91e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.91e-08
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 24640390     165 VATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWN 200
Cdd:smart00320    5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
165-200 4.45e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 4.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 24640390    165 VATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWN 200
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 125-213 7.93e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 53.03  E-value: 7.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   125 LRGHDGDVLDLAWSP-NDVYLASCSIDNTVIIWDAQAFPHSV-------ATLKGHTGLVKGVSWDPLGRF-LASQSDDRS 195
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNPMNYYiMCSSGFDSF 149

                          90
                  ....*....|....*...
gi 24640390   196 IKIWNTMNWSLSHTITEP 213
Cdd:PTZ00420  150 VNIWDIENEKRAFQINMP 167
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 61-97 4.71e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 4.71e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 24640390      61 KMLCQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIW 97
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
61-97 9.31e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 9.31e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24640390     61 KMLCQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIW 97
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
HIRA_B pfam09453
HIRA B motif; The HirA B (Histone regulatory homolog A binding) motif is the essential binding ...
 424-442 1.23e-05

HIRA B motif; The HirA B (Histone regulatory homolog A binding) motif is the essential binding interface between HIRA pfam07569 and ASF1a, of approx. 40 residues. It forms an antiparallel beta-hairpin that binds perpendicular to the strands of the beta-sandwich of ASF1a N-terminal core domain, via beta-sheet, salt bridge and van der Waals interactions. The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The yeast CAF1B proteins which bind H3 also carry this motif at their very C-terminus.


Pssm-ID: 462802  Cd Length: 22  Bit Score: 42.89  E-value: 1.23e-05
                           10
                   ....*....|....*....
gi 24640390    424 QTETRTKDGKRRITPMFIP 442
Cdd:pfam09453    1 QKVTITKDGKKRVAPTLIS 19
PTZ00421 PTZ00421
coronin; Provisional
 67-238 6.00e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.73  E-value: 6.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390    67 DQHLACVN--CVRWsqNGQNLASgSDDKLIMIWRKSAGSSGVF---GTGGMQKNHEswkcfyTLRGHDGDVLDLAWSP-N 140
Cdd:PTZ00421   17 DRHFLNVTpsTALW--DCSNTIA-CNDRFIAVPWQQLGSTAVLkhtDYGKLASNPP------ILLGQEGPIIDVAFNPfD 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   141 DVYLASCSIDNTVIIWD------AQAFPHSVATLKGHTGLVKGVSWDPLGR-FLASQSDDRSIKIWNTMNWSLSHTITep 213
Cdd:PTZ00421   88 PQKLFTASEDGTIMGWGipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIK-- 165

                         170       180
                  ....*....|....*....|....*
gi 24640390   214 feecGGTTHILRLSWSPDGQYLVSA 238
Cdd:PTZ00421  166 ----CHSDQITSLEWNLDGSLLCTT 186
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 76-235 3.26e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.56  E-value: 3.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390   76 VRWSQNGQNLA-----SGSDDklimIWRKSAGSSG---VFGTGGmqknheswkcfytlrghDGDVLDLAWSPNDVYLASC 147
Cdd:COG4946  348 PAWSPDGKSIAyfsdaSGEYE----LYIAPADGSGepkQLTLGD-----------------LGRVFNPVWSPDGKKIAFT 406

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640390  148 SIDNTVIIWDaqafphsVATLK-------GHTGLVKGVSWDPLGRFLA-SQSDD---RSIKIWNTMNWSlSHTITEPFEE 216
Cdd:COG4946  407 DNRGRLWVVD-------LASGKvrkvdtdGYGDGISDLAWSPDSKWLAySKPGPnqlSQIFLYDVETGK-TVQLTDGRYD 478

                        170
                 ....*....|....*....
gi 24640390  217 CGgtthilRLSWSPDGQYL 235
Cdd:COG4946  479 DG------SPAFSPDGKYL 491
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 256-309 7.90e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 7.90e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 24640390     256 WKCDKDFVGHRKAVTCVRFHnsilsrqeNDGSpskplqycCLAVGSRDRSLSVW 309
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFS--------PDGK--------YLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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