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Conserved domains on  [gi|50233779|ref|NP_571805|]
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GDNF family receptor alpha-1a precursor [Danio rerio]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10658249)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF, the glial cell line-derived neurotrophic factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 246-340 2.58e-21

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 87.97  E-value: 2.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779   246 CLTLQVSCKTNYICRSRLADFFTNCQPEPLSLSGClkENYADCLLSYsgligtVMTPNYLRSPKISVSPFCDCSSSGNSK 325
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGC--PNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 50233779   326 EECDRFTEFFTDNAC 340
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 153-236 1.92e-14

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 68.44  E-value: 1.92e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779    153 CLNAAKACNLNDTCKKYRSAYISPCTSRVSTA------EVCNKRKCHKALRQFFDkvppKHSYGMLYCSCPLGDQSACSE 226
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSScpgensEACLRAYCGLALRPFYD----DNSSVLLFCTCAGNRDEECLE 76

                           90
                   ....*....|
gi 50233779    227 RRRQTIVPAC 236
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 32-114 1.82e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 45.71  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779     32 CVKANELCLKEPGCSSK-YRTMRQCVAGRESNFSmatgMEAKDECRLVLDALKQSPLYN--------CRCKRgmKKEKNC 102
Cdd:smart00907   1 CLEALKACELDPVCRSRlADYLSACSPSPSSSCP----GENSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEEC 74

                           90
                   ....*....|..
gi 50233779    103 LRIYWGIYQHLQ 114
Cdd:smart00907  75 LEFRRLFHSNPC 86
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 246-340 2.58e-21

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 87.97  E-value: 2.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779   246 CLTLQVSCKTNYICRSRLADFFTNCQPEPLSLSGClkENYADCLLSYsgligtVMTPNYLRSPKISVSPFCDCSSSGNSK 325
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGC--PNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 50233779   326 EECDRFTEFFTDNAC 340
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 246-340 2.43e-15

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 71.13  E-value: 2.43e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779    246 CLTLQVSCKTNYICRSRLADFFTNCQPEPlsLSGCLKENYADCLLSYsglIGTVMTPNYLRSpkISVSPFCDCssSGNSK 325
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSP--SSSCPGENSEACLRAY---CGLALRPFYDDN--SSVLLFCTC--AGNRD 71

                           90
                   ....*....|....*
gi 50233779    326 EECDRFTEFFTDNAC 340
Cdd:smart00907  72 EECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 153-236 1.92e-14

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 68.44  E-value: 1.92e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779    153 CLNAAKACNLNDTCKKYRSAYISPCTSRVSTA------EVCNKRKCHKALRQFFDkvppKHSYGMLYCSCPLGDQSACSE 226
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSScpgensEACLRAYCGLALRPFYD----DNSSVLLFCTCAGNRDEECLE 76

                           90
                   ....*....|
gi 50233779    227 RRRQTIVPAC 236
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 153-236 3.62e-13

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 64.86  E-value: 3.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779   153 CLNAAKACNLNDTCKKYRSAYISPCTSRVSTAEVC-NKRKCHKALRQFFDKVPPKHSYGMLYCSCPLGDQS--ACSERRR 229
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCpNPARCLRAYRMTPNYVDNLGTSLLLWCTCKGSGNQdeECEEFRR 80


                  ....*..
gi 50233779   230 QTIVPAC 236
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 32-114 1.82e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 45.71  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779     32 CVKANELCLKEPGCSSK-YRTMRQCVAGRESNFSmatgMEAKDECRLVLDALKQSPLYN--------CRCKRgmKKEKNC 102
Cdd:smart00907   1 CLEALKACELDPVCRSRlADYLSACSPSPSSSCP----GENSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEEC 74

                           90
                   ....*....|..
gi 50233779    103 LRIYWGIYQHLQ 114
Cdd:smart00907  75 LEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 32-112 4.75e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 44.83  E-value: 4.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779    32 CVKANELCLKEPGCSSKYRT-MRQCVAGRESnfsmATGMEAKDECRLVL-------DALKQSPLYNCRCKRGMKKEKNCL 103
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADfQSNCQPSPES----CSGCPNPARCLRAYrmtpnyvDNLGTSLLLWCTCKGSGNQDEECE 76


                  ....*....
gi 50233779   104 RIYWGIYQH 112
Cdd:pfam02351  77 EFRRNFTVN 85
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 246-340 2.58e-21

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 87.97  E-value: 2.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779   246 CLTLQVSCKTNYICRSRLADFFTNCQPEPLSLSGClkENYADCLLSYsgligtVMTPNYLRSPKISVSPFCDCSSSGNSK 325
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGC--PNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 50233779   326 EECDRFTEFFTDNAC 340
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 246-340 2.43e-15

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 71.13  E-value: 2.43e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779    246 CLTLQVSCKTNYICRSRLADFFTNCQPEPlsLSGCLKENYADCLLSYsglIGTVMTPNYLRSpkISVSPFCDCssSGNSK 325
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSP--SSSCPGENSEACLRAY---CGLALRPFYDDN--SSVLLFCTC--AGNRD 71

                           90
                   ....*....|....*
gi 50233779    326 EECDRFTEFFTDNAC 340
Cdd:smart00907  72 EECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 153-236 1.92e-14

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 68.44  E-value: 1.92e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779    153 CLNAAKACNLNDTCKKYRSAYISPCTSRVSTA------EVCNKRKCHKALRQFFDkvppKHSYGMLYCSCPLGDQSACSE 226
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSScpgensEACLRAYCGLALRPFYD----DNSSVLLFCTCAGNRDEECLE 76

                           90
                   ....*....|
gi 50233779    227 RRRQTIVPAC 236
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 153-236 3.62e-13

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 64.86  E-value: 3.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779   153 CLNAAKACNLNDTCKKYRSAYISPCTSRVSTAEVC-NKRKCHKALRQFFDKVPPKHSYGMLYCSCPLGDQS--ACSERRR 229
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCpNPARCLRAYRMTPNYVDNLGTSLLLWCTCKGSGNQdeECEEFRR 80


                  ....*..
gi 50233779   230 QTIVPAC 236
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 32-114 1.82e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 45.71  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779     32 CVKANELCLKEPGCSSK-YRTMRQCVAGRESNFSmatgMEAKDECRLVLDALKQSPLYN--------CRCKRgmKKEKNC 102
Cdd:smart00907   1 CLEALKACELDPVCRSRlADYLSACSPSPSSSCP----GENSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEEC 74

                           90
                   ....*....|..
gi 50233779    103 LRIYWGIYQHLQ 114
Cdd:smart00907  75 LEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 32-112 4.75e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 44.83  E-value: 4.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233779    32 CVKANELCLKEPGCSSKYRT-MRQCVAGRESnfsmATGMEAKDECRLVL-------DALKQSPLYNCRCKRGMKKEKNCL 103
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADfQSNCQPSPES----CSGCPNPARCLRAYrmtpnyvDNLGTSLLLWCTCKGSGNQDEECE 76


                  ....*....
gi 50233779   104 RIYWGIYQH 112
Cdd:pfam02351  77 EFRRNFTVN 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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