NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|982742395|ref|NP_571766|]
View 

sphingosine 1-phosphate receptor 1 [Danio rerio]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11607441)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

 Zoom to residue level

show extra options Â»

Show site features     Horizontal zoom: Ã—

List of domain hits

Name Accession Description Interval E-value
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
25-303 8.37e-176

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


:

Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 489.39  E-value: 8.37e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  25 KADSVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMF 104
Cdd:cd15346    1 KLTSVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPTQWFLREGSMF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILF 184
Cdd:cd15346   81 VALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 CTTVFSVILMAIVILYARIYALVRTRSRKLVFRKvaNGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQ 264
Cdd:cd15346  161 CTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRK--NIRKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDVGCK 238
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 982742395 265 TLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15346  239 VKTCSILFKAEYFLVLAVLNSATNPIIYTLTNKEMRRAF 277
 
Name Accession Description Interval E-value
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
25-303 8.37e-176

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 489.39  E-value: 8.37e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  25 KADSVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMF 104
Cdd:cd15346    1 KLTSVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPTQWFLREGSMF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILF 184
Cdd:cd15346   81 VALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 CTTVFSVILMAIVILYARIYALVRTRSRKLVFRKvaNGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQ 264
Cdd:cd15346  161 CTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRK--NIRKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDVGCK 238
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 982742395 265 TLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15346  239 VKTCSILFKAEYFLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
41-292 1.98e-40

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 143.21  E-value: 1.98e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395   41 ENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVytaniLLSGANTYKLTPTQWFFREG-------SMFVALAASVFS 113
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLL-----TLPFWLVYYLNHGDWPFGSAlckivgaLFVVNGYASILL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  114 LLAIAIERHLT---MLKMKLHNNGKTCRVfmLISTVWFIAAILGGLP-VMGWNCI---DSINNCSTVLPL---YHKAYIL 183
Cdd:pfam00001  76 LTAISIDRYLAivhPLRYKRRRTPRRAKV--LILVIWVLALLLSLPPlLFGWTLTvpeGNVTVCFIDFPEdlsKPVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  184 FCTTVFSVILM-AIVILYARIYALVRTRSRKLvfrkvangrGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVA 262
Cdd:pfam00001 154 LISVLGFLLPLlVILVCYTLIIRTLRKSASKQ---------KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSL 224
                         250       260       270
                  ....*....|....*....|....*....|..
gi 982742395  263 CQTLTCSILYKAEW--FLALAVLNSAMNPLIY 292
Cdd:pfam00001 225 ALDCELSRLLDKALsvTLWLAYVNSCLNPIIY 256
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
29-307 1.42e-06

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 49.52  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLlTIWRTKKFHKPMYYFIGNLALSDLLAgVVYTANILLSGANTYKLTPTQWFFREGSMFVALA 108
Cdd:PHA02834  33 VFYILLFIFGLIGNVLVI-AVLIVKRFMFVVDVYLFNIAMSDLML-VFSFPFIIHNDLNEWIFGEFMCKLVLGVYFVGFF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVFSLLAIAIERHLTMLKMKLHNNgKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCST-VLPLYHK-----AYI 182
Cdd:PHA02834 111 SNMFFVTLISIDRYILVVNATKIKN-KSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQcIFNDYHEnfswsAFF 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 183 LFCTTVFSVILMAIVILYARIYALVRTRSRKlvfrkvangrgsNKSSEKSMALLKTVIIVLSCFiacWAPLFILL----- 257
Cdd:PHA02834 190 NFEINIFGIVIPLIILIYCYSKILYTLKNCK------------NKNKTRSIKIILTVVTFTVVF---WVPFNIVLfinsl 254
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 258 ----LLDVACQTLTcSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAFIKML 307
Cdd:PHA02834 255 qsvgLIDIGCYHFK-KIVYSIDIAELISFVHCCVNPIIYAFVGKNFKKVFKNMF 307
 
Name Accession Description Interval E-value
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
25-303 8.37e-176

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 489.39  E-value: 8.37e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  25 KADSVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMF 104
Cdd:cd15346    1 KLTSVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPTQWFLREGSMF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILF 184
Cdd:cd15346   81 VALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 CTTVFSVILMAIVILYARIYALVRTRSRKLVFRKvaNGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQ 264
Cdd:cd15346  161 CTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRK--NIRKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDVGCK 238
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 982742395 265 TLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15346  239 VKTCSILFKAEYFLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
25-303 1.68e-141

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 402.23  E-value: 1.68e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  25 KADSVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMF 104
Cdd:cd15102    1 GATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGARTLRLSPAQWFLREGSMF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILF 184
Cdd:cd15102   81 VALSASVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIGACWLISLLLGGLPILGWNCLGALDACSTVLPLYSKHYVLF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 CTTVFSVILMAIVILYARIYALVRTRSRKLVfrkvangrgSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQ 264
Cdd:cd15102  161 CVTIFAGILAAIVALYARIYCLVRASGRKAT---------RASASPRSLALLKTVLIVLLVFIACWGPLFILLLLDVACP 231
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 982742395 265 TLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15102  232 VKTCPILYKADWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
28-303 1.50e-125

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 361.83  E-value: 1.50e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVAL 107
Cdd:cd15345    4 TIFFLVICSFIVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTQWFLREGSMFVAL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFCTT 187
Cdd:cd15345   84 GASTFSLLAIAIERHLTMIKMRPYDANKRYRVFLLIGTCWLISVLLGALPILGWNCLDNLPDCSTILPLYSKKYVAFCIS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 188 VFSVILMAIVILYARIYALVRTRSRKLVfrkvangrgSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQTLT 267
Cdd:cd15345  164 IFIAILVAIVILYARIYILVKSSSRRVT---------NHRNSERSMALLRTVVIVVGVFIACWSPLFILLLIDVACEVKQ 234
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 982742395 268 CSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15345  235 CPILYKADWFIALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
25-302 2.81e-118

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 343.34  E-value: 2.81e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  25 KADSVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMF 104
Cdd:cd15348    1 KADAVAFLAVCAFIVLENLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAGAAYAANILMSGANTLKLTPALWFLREGGVF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILF 184
Cdd:cd15348   81 ITLTASVFSLLAIAIERHITMVRMKPYPGDKRGRMFLLIGAAWLVSILLGVLPILGWNCLGNLDACSTVLPLYAKSYILF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 CTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGsnKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQ 264
Cdd:cd15348  161 CITVFLAILAAIVVLYARIYRIVKANSQRLGALPTRKGRA--RRSQKYLALLKTVTIVLGTFVACWLPLFLLLLLDVSCP 238
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 982742395 265 TLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15348  239 AQACPVLLKADYFLGLAMINSLLNPIIYTLTSRDMRRA 276
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
28-303 6.91e-106

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 311.75  E-value: 6.91e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVAL 107
Cdd:cd15347    4 SIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANILLSGSVTFRLTPVQWFIREGTAFITL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFCTT 187
Cdd:cd15347   84 SASVFSLLAIAIERHVAITKVKLYGSDKNCRMVLLIGACWVISIVLGGLPILGWNCIGNLEDCSTVLPLYSKHYILFVVT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 188 VFSVILMAIVILYARIYALVRTRSRKLvfrkvangrgsnkSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQTLT 267
Cdd:cd15347  164 IFSIILLSIVILYVRIYCIVRSSHAEM-------------AAPQTLALLKTVTIVLGVFIVCWLPAFIILLLDTSCKVKS 230
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 982742395 268 CSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15347  231 CPILYKADYFFSVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
29-302 3.33e-93

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 279.36  E-value: 3.33e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVALA 108
Cdd:cd15349    5 VLFICISVLIILENLLVLLAILRRVRLRRWVYICLANIALSDLLTGTSYLVNICLSGERTFRLTPALWFLREGLLFTALA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVFSLLAIAIERHLTMLKMKLHNNG-KTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFCTT 187
Cdd:cd15349   85 ASTFSLLVTAVERYATMVRPVAENTAtKTYRVYGMIVLCWILAFLIGFLPLLGWNCLCDFRSCSSLLPLYSKSYILFCLV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 188 VFSVILMAIVILYARIYALVRTRSRKLVfrkvangrgSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQTLT 267
Cdd:cd15349  165 IFFIILLTIIGLYFAIYCLVRASGQRVI---------SARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCSSRS 235
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 982742395 268 CSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15349  236 CKPLFGMEWVLALAVLNSAINPLIYSFRSLEVRRA 270
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
28-303 8.50e-91

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 273.40  E-value: 8.50e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVAL 107
Cdd:cd14972    2 LVVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVMGWNCIDSIN-NCSTVLPLYHKAYILFC 185
Cdd:cd14972   82 LASAYSLLAIAVDRYISIVHGLTYVNNVTNkRVKVLIALVWVWSVLLALLPVLGWNCVLCDQeSCSPLGPGLPKSYLVLI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 186 TTVFSVILMAIVILYARIYALVRtrsRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQT 265
Cdd:cd14972  162 LVFFFIALVIIVFLYVRIFWCLW---RHANAIAARQEAAVPAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPS 238
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 982742395 266 lTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14972  239 -VCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
32-303 2.33e-70

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 221.21  E-value: 2.33e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVALAASV 111
Cdd:cd15342    8 LTVSVIVLLTNLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVAYLFLMFHTGPWTAKLSLYQWFLRQGLLDTSLTASV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 112 FSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFCTTVFSV 191
Cdd:cd15342   88 ANLLAIAVERHQTIFTMQLHSKMSNQRVVILIFGIWMVALILGLIPAMGWNCLCDLKRCSTMAPLYSRSYLVFWALSNLL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 192 ILMAIVILYARIYALVRTRSRklvfRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQTlTCSIL 271
Cdd:cd15342  168 TFLIMVAVYTRIFIYVRRKSQ----RMSEHHSSHPRYRETVLGLMKTVVIILGAFVVCWTPGQVVLLLDGLGCE-SCNVL 242
                        250       260       270
                 ....*....|....*....|....*....|..
gi 982742395 272 YKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15342  243 AYEKYFLLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
32-303 3.41e-69

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 218.15  E-value: 3.41e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVALAASV 111
Cdd:cd15101    8 ITVCIFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGLAYFFLMFNTGPNTRRLTVSTWFLRQGLLDTSLTASV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 112 FSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFCTTVFSV 191
Cdd:cd15101   88 ANLLAIAVERHISVMRMQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSVGWNCLCAIDACSNMAPLYSRSYLVFWAISNLV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 192 ILMAIVILYARIYALVRTRSRKLvfrkVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACqTLTCSIL 271
Cdd:cd15101  168 TFLVMVVVYARIFVYVRRRTNRM----SPHTSGSIRNRDTMMSLLKTVVIVLGAFVVCWTPGLVVLLLDGLC-CRQCNVL 242
                        250       260       270
                 ....*....|....*....|....*....|..
gi 982742395 272 YKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15101  243 AVEKFFLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
32-303 7.04e-63

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 201.79  E-value: 7.04e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVALAASV 111
Cdd:cd15344    8 ITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 112 FSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFCTTVFSV 191
Cdd:cd15344   88 ANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 192 ILMAIVILYARIYALVRTRSrklvFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQtlTCSIL 271
Cdd:cd15344  168 TFVVMVVLYAHIFGYVRQRT----MRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCP--QCDVL 241
                        250       260       270
                 ....*....|....*....|....*....|..
gi 982742395 272 YKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15344  242 AYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
33-303 9.74e-61

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 196.64  E-value: 9.74e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  33 IVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVALAASVF 112
Cdd:cd15343    9 FCCLFIFVSNSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDTSLSASLT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 113 SLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFCTTVFSVI 192
Cdd:cd15343   89 NLLVIAVERHISIMRMKVHSNLTKRRVTLLIALVWAIAIFMGAVPTLGWNCICNISACSSLAPIYSRSYLVFWSVSNLVV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 193 LMAIVILYARIYALVRTRSRKLvfrkVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDvACQTLTCSILY 272
Cdd:cd15343  169 FLIMVVVYLRIYVYVQRKTNVL----SPHTSGSINRRRTPIKLMKTVMTVLGAFVICWTPGLVVLLLD-GLNCTRCGVQH 243
                        250       260       270
                 ....*....|....*....|....*....|.
gi 982742395 273 KAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15343  244 VKRWFLLLALLNSVMNPIIYSYKDEEMWGTM 274
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
28-296 2.82e-45

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 156.29  E-value: 2.82e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYT-ANILLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIpFSLVSLLLGRWWFGDALCKLLGFLQSVS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLP----LYHKAY 181
Cdd:cd00637   82 LLASILTLTAISVDRYLAIVHpLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCwpdlTLSKAY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 ILFCTTVFSVI-LMAIVILYARIYALVRTRSRKLvfRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLD 260
Cdd:cd00637  162 TIFLFVLLFLLpLLVIIVCYVRIFRKLRRHRRRI--RSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLD 239
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 982742395 261 VACQTLTCSILYKAEWFLALAVLNSAMNPLIYTLTS 296
Cdd:cd00637  240 VFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
28-303 2.77e-43

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 150.79  E-value: 2.77e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYtanilLSGANTYKLTPTQWFFREGSMFVAL 107
Cdd:cd14967    3 AVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLV-----MPFSAVYTLLGYWPFGPVLCRFWIA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 A------ASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTV-LPLYHK 179
Cdd:cd14967   78 LdvlcctASILNLCAISLDRYLAITRpLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCEcEFTPNK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 AYILFCTTV-FSVILMAIVILYARIYALVRTRsrklvfRKVAngrgsnksseksmallKTVIIVLSCFIACWAPLFILLL 258
Cdd:cd14967  158 IYVLVSSVIsFFIPLLIMIVLYARIFRVARRE------LKAA----------------KTLAIIVGAFLLCWLPFFIIYL 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 982742395 259 LDVACQTLTCS-ILYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14967  216 VSAFCPPDCVPpILYAV--FFWLGYLNSALNPIIYALFNRDFRRAF 259
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
41-292 1.98e-40

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 143.21  E-value: 1.98e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395   41 ENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVytaniLLSGANTYKLTPTQWFFREG-------SMFVALAASVFS 113
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLL-----TLPFWLVYYLNHGDWPFGSAlckivgaLFVVNGYASILL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  114 LLAIAIERHLT---MLKMKLHNNGKTCRVfmLISTVWFIAAILGGLP-VMGWNCI---DSINNCSTVLPL---YHKAYIL 183
Cdd:pfam00001  76 LTAISIDRYLAivhPLRYKRRRTPRRAKV--LILVIWVLALLLSLPPlLFGWTLTvpeGNVTVCFIDFPEdlsKPVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  184 FCTTVFSVILM-AIVILYARIYALVRTRSRKLvfrkvangrGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVA 262
Cdd:pfam00001 154 LISVLGFLLPLlVILVCYTLIIRTLRKSASKQ---------KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSL 224
                         250       260       270
                  ....*....|....*....|....*....|..
gi 982742395  263 CQTLTCSILYKAEW--FLALAVLNSAMNPLIY 292
Cdd:pfam00001 225 ALDCELSRLLDKALsvTLWLAYVNSCLNPIIY 256
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
28-303 4.77e-31

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 119.24  E-value: 4.77e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFH-KPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd15340    4 AVLSLTLGTFTVLENLLVLCVILHSRSLRcRPSYHFIGSLAVADLLGSVIFVYSFLDFHVFHRKDSPNVFLFKLGGVTAS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFC 185
Cdd:cd15340   84 FTASVGSLFLTAIDRYISIHRpLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLLGWNCKKLNSVCSDIFPLIDETYLMFW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 186 TTVFSVILMAIVILYARIY---------ALVRTRSRKLVFRKVANGRGSNKSSEKS---MALLKTVIIVLSCFIACWAPL 253
Cdd:cd15340  164 IGVTSVLLLFIVYAYMYILwkahhhavrMLQRGTQKSIIVYTSEDGKVQTTRPDQTrmdIRLAKTLVLILVVLIICWGPL 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 982742395 254 FILLLLDVACQtLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15340  244 LAIMVYDVFGK-MNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
25-303 6.94e-30

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 115.70  E-value: 6.94e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  25 KADSVVFIIVCCFIILENVLVLLTIWRTKKFH-KPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSM 103
Cdd:cd15099    1 KAIAVLCFLAGPVTFLENILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFLDFHVFHQRDSRNLFLFKLGGV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVALAASVFSLLAIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYI 182
Cdd:cd15099   81 TMAFTASVGSLLLTALDRYLCIYQPSNYKLLVTrTRAKVAILLMWCVTIIISFLPLMGWRCKTWDSPCSRLFPYIDRHYL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 183 LFCTTVFSVILMAIVilYARIYALVRTRSRKLVFRKVANGRGSNKSSEK---SMALLKTVIIVLSCFIACWAPLFILLLL 259
Cdd:cd15099  161 ASWTGLQLVLLFLII--YAYPYILWKAHRHEANMGGPKLGRQQVKGQARmrmDIRLAKTLSLILLVLAICWLPVLAFMLV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 982742395 260 DVACqTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15099  239 DVRV-TLTNKQKRMFAFCSMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
30-303 3.36e-29

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 113.89  E-value: 3.36e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCfiILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV-VYTANILLSgantykLTPTQWFFreGSMFVAL- 107
Cdd:cd14968    8 VLIAVLS--VLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGAlAIPLAILIS------LGLPTNFH--GCLFMACl 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 -----AASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWN--------CIDSINNC--S 171
Cdd:cd14968   78 vlvltQSSIFSLLAIAIDRYLAIKIpLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNngaplesgCGEGGIQClfE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVLPLYHKAYILFCTTVFsVILMAIVILYARIYALVRTRSRKLVFRKVanGRGSNKSSEKSMALLKTVIIVLSCFIACWA 251
Cdd:cd14968  158 EVIPMDYMVYFNFFACVL-VPLLIMLVIYLRIFRVIRKQLRQIESLLR--SRRSRSTLQKEVKAAKSLAIILFLFALCWL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 252 PLFILllldvACQTLTCSILYKAEWFLALAVL----NSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14968  235 PLHII-----NCITLFCPECKVPKILTYIAILlshaNSAVNPIVYAYRIRKFRQTF 285
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
30-303 1.05e-28

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 112.20  E-value: 1.05e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV---VYTANILLSGANTykLTPTQWFFRE-----G 101
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVsnaLETIVIILLNNGY--LVPRDSFEQHidnviD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMFV-ALAASVFSLLAIAIERHLTML-KMKLHNNGKTCRVFMLISTVWFIAAIlgglpvmgwncidsinnCSTVLPLY-- 177
Cdd:cd15103   84 SMICsSLLASICSLLAIAVDRYITIFyALRYHSIMTVRRAGVIITAIWVFCTV-----------------CGILFIIYsd 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKLvfrkVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILL 257
Cdd:cd15103  147 SVPVIICLISMFFAMLVLMASLYVHMFLLARSHVKKI----AALPGQRSTRQRANMKGAVTLTILLGVFIFCWAPFFLHL 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 982742395 258 LLDVAC-QTLTCSILYKA-EWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15103  223 TLMISCpSNPYCACYMSHfNVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
30-302 6.11e-28

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 110.31  E-value: 6.11e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFI-----ILENVLVLLTIWRTKKFH-KPMYYFIGNLALSDLLAGVVYTANIL----LSGANTYKLtptqWFFR 99
Cdd:cd15341    1 IAIAVLCTLcgllcILENVAVLYLILSSPKLRrKPSYLFIGSLALADFLASVVFACSFVdfhvFHGVDSSAI----FLLK 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 100 EGSMFVALAASVFSLLAIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYH 178
Cdd:cd15341   77 LGGVTMSFTASLGSLLLMAFDRYVCIYYPSEYKALVTrKRALVALAVMWVLTALIAYLPLMGWNCCPLNSPCSELFPLIP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 KAYILFCTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMaLLKTVIIVLSCFIACWAPLFILLL 258
Cdd:cd15341  157 NDYLLSWLLLVAILLSGIIYTYGHVLWKAHKHVVYMEKHQDQQGPGNARMRLDVR-LAKTLGLVLAVLLICWSPVLALMM 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 982742395 259 LDVACqTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15341  236 HSLFT-SLSDHIKKAFAFCSTLCLVNSMVNPIIYALRSRELRSS 278
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
30-303 1.18e-26

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 106.95  E-value: 1.18e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYT-ANILLSGANTYKLTPTQWFFR------EGS 102
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAwETITIYLLNNRHLVIEDAFVRhidnvfDSL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 MFVALAASVFSLLAIAIERHLTML-KMKLHNNGKTCRVFMLISTVWFIAailgglpvmgwncidsiNNCSTVLPLYHKA- 180
Cdd:cd15354   86 ICISVVASMCSLLAIAVDRYVTIFyALRYHNIMTVRRAGIIIACIWTFC-----------------TGCGIIFILYSESt 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 181 YILFC-TTVFSVILMAIVILYARIYALVRTRSRKLvfrkVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLL 259
Cdd:cd15354  149 YVIIClITMFFAMLFLMVSLYIHMFLLARTHVKRI----AALPGYNSVRQRTSMKGAVTLTILLGIFIVCWAPFFLHLIL 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 982742395 260 DVAC-QTLTCS-ILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15354  225 MISCpQNLYCVcFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
33-302 1.20e-26

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 106.79  E-value: 1.20e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  33 IVCCfiilENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG---VVYTANILLSGANTYKLTPTqwffreGSMFVALAA 109
Cdd:cd15100   13 LIAC----ENAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGlglILHFVFRYCVYSEALSLVSV------GLLVAAFSA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 110 SVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFCTTV 188
Cdd:cd15100   83 SVCSLLAITVDRYLSLYNaLTYYSERTLTFTYVMLALLWTLALGLGLLPVLGWNCLREGSSCSVVRPLTKNHLAVLAVAF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 189 FsvILMAIVI-LYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMAllkTVIIVLSCFIACWAPLFILLLLDVAcqtlT 267
Cdd:cd15100  163 L--LVFALMLqLYAQICRIVLRHAHQIALQRHFLAPSHYVATRKGVS---TLALILGTFAACWIPFAVYCLLGDG----S 233
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 982742395 268 CSILYKAEWFLAlAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15100  234 SPALYTYATLLP-ATYNSMINPIIYAFRNQDIQKV 267
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
28-303 1.27e-26

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 106.26  E-value: 1.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytanILLSGANTYKLTPTqWFFreGSMFVAL 107
Cdd:cd15064    4 SVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAV-----LVMPLSAVYELTGR-WIL--GQVLCDI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 ---------AASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSI--NNCstvLP 175
Cdd:cd15064   76 wisldvtccTASILHLCVIALDRYWAITDaVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEdpSEC---LI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 176 LYHKAYILFCTTV-FSVILMAIVILYARIYAlVRTRSRKLVfrkvangrgsnksseksmallKTVIIVLSCFIACWAPLF 254
Cdd:cd15064  153 SQDIGYTIFSTFGaFYIPLLLMLILYWKIYR-AAARERKAA---------------------KTLGIILGAFIVCWLPFF 210
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 982742395 255 ILLLLDVACQTLTCSILYKAeWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15064  211 LVALIVPLCSHCWIPLALKS-FFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
32-303 1.74e-26

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 106.26  E-value: 1.74e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCC---FIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANI----LLSGANTYKLTPtqwffreGSMF 104
Cdd:cd15961    5 IVLCTsgtLISCENAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLILNFifayLLQSEAAKLVTV-------GLIV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCR-VFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLY-HKAYI 182
Cdd:cd15961   78 ASFSASVCSLLAITVDRYLSLYYALTYNSERTVTfTYVMLVLLWGASICLGLLPVMGWNCLADESTCSVVRPLTkNNAAI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 183 LFCTTVFSVILMaiVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMAllkTVIIVLSCFIACWAPLFILLLldVA 262
Cdd:cd15961  158 LSVSFLLMFALM--LQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVS---TLAIILGTFAACWMPFTLYSL--IA 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 982742395 263 CQTLTCSILYKAewfLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15961  231 DYTYPSIYTYAT---LLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
28-303 2.86e-26

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 106.42  E-value: 2.86e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytaniLLSGANTYKLTPTQWFFRE------G 101
Cdd:cd15056    4 STFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAV------LVMPFGAIELVNNRWIYGEtfclvrT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMFVAL-AASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVM-GWNCIDSIN--------NCS 171
Cdd:cd15056   78 SLDVLLtTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMqGWNHIGIEDliafncasGST 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVLPLYHKAYILFCTTV-FSVILMAIVILYARIYALVRTRSRKLVFRKVANG--------RGSNKSSEKSMAllKTVIIV 242
Cdd:cd15056  158 SCVFMVNKPFAIICSTVaFYIPALLMVLAYYRIYVAAREQAHQIRSLQRAGSsnheadqhRNSRMRTETKAA--KTLGII 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 982742395 243 LSCFIACWAPLFILLLLDVACQTLTCSILYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15056  236 MGCFCVCWAPFFVTNIVDPFIGYRVPYLLWTA--FLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
28-303 1.03e-25

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 103.96  E-value: 1.03e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVccFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYkltptqWFFREG--SMFV 105
Cdd:cd15059    6 IVSVVIL--LIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGY------WYFGSVwcEIWL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 AL-----AASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVMGW----NCIDSINNCS-TVL 174
Cdd:cd15059   78 ALdvlfcTASIVNLCAISLDRYWSVTQAVEYNLKRTPrRAKAMIAAVWIISAVISLPPLFGWkdeqPWHGAEPQCElSDD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PlyhkAYILF-CTTVFSVILMAIVILYARIYALVRTRSRKLVFrkvangrgsnksseksmallktVI-IVLSCFIACWAP 252
Cdd:cd15059  158 P----GYVLFsSIGSFYIPLLIMIIVYARIYRAAKRKERRFTL----------------------VLgVVMGAFVLCWLP 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 253 LFILLLLDVACQtlTCSI---LYKaeWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15059  212 FFFTYPLVVVCK--TCGVpelLFK--FFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
29-301 1.45e-25

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 103.81  E-value: 1.45e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG---VVYTANILLSGANTYKLTPTqwffreGSMFV 105
Cdd:cd15963    5 VVLCISGTVISCENAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGlglILHFAFVYCIQSAPVNLVTV------GLLAP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 ALAASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLyHKAYILF 184
Cdd:cd15963   79 SFTASVSSLLAITIDRYLSLYNALTYYSERTVtRTYIMLILTWGASLCLGLLPVVGWNCLKDPSTCSVVKPL-TKNHLVI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 CTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMAllkTVIIVLSCFIACWAPLFILLLLDVAcq 264
Cdd:cd15963  158 LSISFFMVFALMLQLYAQICRIVCRHAHQIALQRHFLPTSHYVTTRKGIA---TLAVILGTFASCWLPFAVYCLLGDY-- 232
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 982742395 265 tlTCSILYKAEWFLAlAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15963  233 --TYPALYTYATLLP-ATYNSMINPIIYAFRNQEIQK 266
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
29-303 2.90e-25

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 102.82  E-value: 2.90e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFI-ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG-VVYTANILLSGANTYKLTPTQWFFREGSMFV- 105
Cdd:cd15067    3 GVVLSLFCLVtVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGsIVMPFSILHEMTGGYWLFGRDWCDVWHSFDVl 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 ALAASVFSLLAIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTV-LPLYHKAYIL 183
Cdd:cd15067   83 ASTASILNLCVISLDRYWAITDPISYPSRMTkRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQcLFTDDSGYLI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 184 FCTTV-FSVILMAIVILYARIYalvRTRSRKlvfRKVAngrgsnksseksmallKTVIIVLSCFIACWAPLFILLLLDVA 262
Cdd:cd15067  163 FSSCVsFYIPLVVMLFTYYRIY---RAAAKE---QKAA----------------KTLGIVMGVFILCWLPFFVTNILIGF 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 982742395 263 CQTLTCS---ILYKaeWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15067  221 CPSNCVSnpdILFP--LVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
28-303 5.77e-25

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 102.04  E-value: 5.77e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytanILLSGANTYKLTPTQWFFRE--GSMFV 105
Cdd:cd15053    4 ALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAI-----LVMPFAVYVEVNGGKWYLGPilCDIYI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 AL-----AASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVMGWNciDSINNCSTVLPLYHK 179
Cdd:cd15053   79 AMdvmcsTASIFNLCAISIDRYIAVTQPIKYARQKNSkRVLLTIAIVWVVSAAIACPLLFGLN--NVPYRDPEECRFYNP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 AYILFCTTV-FSVILMAIVILYARIYALVRtRSRKLVfrkvangrgsnksseksmallKTVIIVLSCFIACWAPLFILLL 258
Cdd:cd15053  157 DFIIYSSISsFYIPCIVMLLLYYRIFRALR-REKKAT---------------------KTLAIVLGVFLFCWLPFFTLNI 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 982742395 259 LDVACQTL---TCS----ILYKAEWflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15053  215 LNAICPKLqnqSCHvgpaLFSLTTW---LGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
30-303 8.09e-25

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 102.31  E-value: 8.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFII-----LENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV---YT--ANILLS---GANTYKLTPTqw 96
Cdd:cd15207    1 VLFIVSYSLIfllcvVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFcmpFTlvDNILTGwpfGDVMCKLSPL-- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  97 ffregSMFVALAASVFSLLAIAIERHLTML---KMKLHNNgktcRVFMLISTVWFIAAILG--GLPVMGWNCIDSINN-- 169
Cdd:cd15207   79 -----VQGVSVAASVFTLVAIAVDRYRAVVhptEPKLTNR----QAFVIIVAIWVLALAIMipQALVLEVKEYQFFRGqt 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 170 ---CSTVLP--LYHKAYilfCTTVFSVI----LMAIVILYARIyalvrtrSRKLVFRKV-ANGRGSNKS----SEKSMAL 235
Cdd:cd15207  150 vhiCVEFWPsdEYRKAY---TTSLFVLCyvapLLIIAVLYVRI-------GYRLWFKPVpGGGSASREAqaavSKKKVRV 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 236 LKTVIIVLSCFIACWAPLFILLLLDVACQtLTCS---ILYK-----AEWflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15207  220 IKMLIVVVVLFALSWLPLHTVTMLDDFGN-LSPNqreVLYVyiypiAHW---LAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
38-302 9.27e-25

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 101.55  E-value: 9.27e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  38 IILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytaNILLSGANTYKL-TPTQWFFREGSMFVALAASVFSLLA 116
Cdd:cd15962   14 IACENAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGC----GLILNFVFQYVIqSETISLITVGFLVASFTASVSSLLA 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 117 IAIERHLTMLKMKLHNNGKTCR-VFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLyHKAYILFCTTVFSVILMA 195
Cdd:cd15962   90 ITVDRYLSLYNALTYYSEKTVLgVHLMLAATWGVSLCLGLLPVLGWNCLEERASCSIVRPL-TKSNVTLLSASFFFIFIL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 196 IVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMAllkTVIIVLSCFIACWAPLFILLLldVACQTLTCSILYKAe 275
Cdd:cd15962  169 MLHLYIKICKIVCRHAHQIALQQHFLTASHYVATKKGVS---TLAIILGTFGASWLPFAIYCV--VGDHEYPAVYTYAT- 242
                        250       260
                 ....*....|....*....|....*..
gi 982742395 276 wfLALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15962  243 --LLPATYNSMINPIIYAYRNQEIQRS 267
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
29-303 9.28e-25

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 101.40  E-value: 9.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYT-ANILLSGANTYKLTPTQWFFRE-----GS 102
Cdd:cd15350    5 EVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTlENILIILADMGYLNRRGPFETKlddimDS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 MFV-ALAASVFSLLAIAIERHLTML-KMKLHNNGKTCRVFMLISTVWFIAAILGGLpvmgwncidsinncsTVLPLYHKA 180
Cdd:cd15350   85 LFClSLLGSIFSILAIAADRYITIFhALRYHNIMTMRRTLVILAIIWTFCGGSGIL---------------MILFFHFVA 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 181 YILFCTTVFSVILMAIVILYARIYALVRTRSrklvfRKVANGRGSNKSSEKS-MALLKTVIIVLSCFIACWAPLFILLLL 259
Cdd:cd15350  150 TVICFTVLFFLMLVLILCLYVHMFLLARSHA-----RKIASLPNHHAQHQRSnMRGAITLTILLGVFVCCWAPFVLHLLL 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 982742395 260 DVACQTLTCSILYKAEWFL--ALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15350  225 MMFCPMNPYCACYRSLFQVngTLIMSHAVIDPAIYAFRSPELRNTF 270
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
28-303 2.15e-24

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 101.14  E-value: 2.15e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVytaNILLS-GANTYKLtptqWFFREG----- 101
Cdd:cd14993    4 IVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLF---CMPLTlLENVYRP----WVFGEVlckav 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 --SMFVALAASVFSLLAIAIERHLTM---LKMKLHNNGKTCRVfmLISTVWFIAAILgGLPVMGWNCIDSINNCSTV--- 173
Cdd:cd14993   77 pyLQGVSVSASVLTLVAISIDRYLAIcypLKARRVSTKRRARI--IIVAIWVIAIII-MLPLLVVYELEEIISSEPGtit 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 174 ---------LPLYHKAYILFCTTVFSVI-LMAIVILYARIyalvrtrSRKLVFRKVANGRGSNKSSEKSMAL------LK 237
Cdd:cd14993  154 iyictedwpSPELRKAYNVALFVVLYVLpLLIISVAYSLI-------GRRLWRRKPPGDRGSANSTSSRRILrskkkvAR 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982742395 238 TVIIVLSCFIACWAPLFIL-LLLDVACQtltcSILYKAEWFLA-------LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14993  227 MLIVVVVLFALSWLPYYVLsILLDFGPL----SSEESDENFLLilpfaqlLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
30-303 4.83e-24

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 99.60  E-value: 4.83e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFR------EGSM 103
Cdd:cd15353    6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDAQSFTVnidnviDSVI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVALAASVFSLLAIAIERHLTML-KMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMgwncidsinncstvlpLYHKAYI 182
Cdd:cd15353   86 CSSLLASICSLLSIAVDRYFTIFyALQYHNIMTVRRAGVIITCIWTACTVSGVLFII----------------YSDSSVV 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 183 LFC-TTVFSVILMAIVILYARIYALVRTRSRKLVfrkVANGRGSNKSSeKSMALLKTVIIVLSCFIACWAPLFILLLLDV 261
Cdd:cd15353  150 IIClISMFFTMLALMASLYVHMFLLARLHIKRIA---VLPGTGPIRQG-ANMKGAITLTILLGVFVVCWAPFFLHLIFYI 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 982742395 262 ACQTLTCSILYKAEW--FLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15353  226 SCPRNPYCVCFMSHFnmYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
37-303 5.89e-24

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 99.76  E-value: 5.89e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  37 FIILENVLVLLTIWRTKKFHK-PMYYFIGNLALSDLLAGVV---YTANILLSGANtykltPTQWFFREGSM-FVAL--AA 109
Cdd:cd15104   12 LIITGNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVGLAipgLATDELLSDGE-----NTQKVLCLLRMcFVITscAA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 110 SVFSLLAIAIERHLTmLKMKLH--NNGKTCRVFMLISTVWFIAAILGGLPVM--GWNCIDSINNCS---TVLPLYHkaYI 182
Cdd:cd15104   87 SVLSLAAIAFDRYLA-LKQPLRykQIMTGKSAGALIAGLWLYSGLIGFLPLIspQFQQTSYKGKCSffaAFHPRVL--LV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 183 LFCTTVFSVILMaIVILYARIYALVRTRSRKLVFRKVANGRGSNKS-SEKSMALLKTVIIVLSCFIACWAPLFILLLLDV 261
Cdd:cd15104  164 LSCMVFFPALLL-FVFCYCDILKIARVHSRAIYKVEHALARQIHPRrTLSDFKAARTVAVLIGCFLLSWLPFQITGLVQA 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 982742395 262 ACQTLTCSILYKaEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15104  243 LCDECKLYDVLE-DYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
29-303 6.91e-24

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 99.71  E-value: 6.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFI---ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytanILLSGANTYKLTPtQWFFreG---- 101
Cdd:cd15051    2 VLGVVLAVIIlltVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGL-----LVLPFSAIYELRG-EWPL--Gpvfc 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 ----SMFVAL-AASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPV-MGWNCIDsinncSTVL 174
Cdd:cd15051   74 niyiSLDVMLcTASILNLFAISLDRYLAITApLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIhLGWNTPD-----GRVQ 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAYILFCTTVFSVILMAIV----------ILYARIYALVRTRSRklvfRKVANGRGSNKSSEKSMALLK------T 238
Cdd:cd15051  149 NGDTPNQCRFELNPPYVLLVAIGtfylpllimcGVYLRIFRIAREQAK----RINALTPASTANSSKSAATARehkatvT 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 239 VIIVLSCFIACWAPLFILLLLDVACQtltCSILYKAEWF-LALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15051  225 LAAVLGAFIICWFPYFTYFTYRGLCG---DNINETALSVvLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
29-303 1.33e-23

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 98.11  E-value: 1.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILE----NVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytanILLSGANTYKLTpTQWFFREG--S 102
Cdd:cd15329    1 VLIGIVLLIIILGtvvgNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVAL-----LVMPLAIIYELS-GYWPFGEIlcD 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 MFVAL-----AASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPl 176
Cdd:cd15329   75 VWISFdvllcTASILNLCAISVDRYLVITRpLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPGVCQVSQ- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 yHKAYILFCTTV-FSVILMAIVILYARIYALVrTRSRKLVfrkvangrgsnksseksmallKTVIIVLSCFIACWAPLFI 255
Cdd:cd15329  154 -DFGYQIYATFGaFYIPLIVMLVLYYKIYRAA-KSERKAI---------------------KTLGIIMGAFTLCWLPFFI 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 982742395 256 L-LLLDVACQTLTCSI-LYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15329  211 LaLLRPFLKPIKCSCIpLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
28-303 1.08e-22

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 96.12  E-value: 1.08e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYkltptqWFFRE------- 100
Cdd:cd14969    4 AVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGR------WSFGDpgcviyg 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 -GSMFVALaASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCID---SINNCS---TV 173
Cdd:cd14969   78 fAVTFLGL-VSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYGLFWALPPLFGWSSYVpegGGTSCSvdwYS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 174 LPLYHKAYILFCTTVFSVI-LMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMAllKTVIIVLSCFIACWAP 252
Cdd:cd14969  157 KDPNSLSYIVSLFVFCFFLpLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKKAEKKVA--KMVLVMIVAFLIAWTP 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 253 LFILLLLdvacqtltcSILYKAEWFLALAVLNSAM--------NPLIYTLTSNEMRRAF 303
Cdd:cd14969  235 YAVVSLY---------VSFGGESTIPPLLATIPALfaksstiyNPIIYVFMNKQFRRAL 284
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
32-303 1.16e-22

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 95.50  E-value: 1.16e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCCFIilENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTAnilLSGANTYKLtptQWFFREG--SMFVAL-- 107
Cdd:cd15331   10 LILATII--GNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMP---LSAVYEVSQ---HWFLGPEvcDMWISMdv 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 ---AASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGW---NCIDSINNCSTVLPLYHKAY 181
Cdd:cd15331   82 lccTASILHLVAIALDRYWAVTNIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWkdeDDLDRVLKTGVCLISQDYGY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 ILFCT-TVFSVILMAIVILYARIYALVRtRSRKLVfrkvangrgsnksseksmallKTVIIVLSCFIACWAPLFILLLLD 260
Cdd:cd15331  162 TIFSTvGAFYVPLLLMIIIYWKIYQAAK-RERKAA---------------------RTLAIITGAFVVCWLPFFLVALVM 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 982742395 261 VACQTLtCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15331  220 PFCGAW-QISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
31-303 1.90e-22

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 95.88  E-value: 1.90e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  31 FIIVccFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvyTANILLSGANTYKLTPtQWFFREG--SMFVAL- 107
Cdd:cd15065    8 LIIV--LAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLL-----VALLVMTFAVVNDLLG-YWLFGETfcNIWISFd 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 ----AASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPV-MGWNCIDSINNC-STVLPLYHKA 180
Cdd:cd15065   80 vmcsTASILNLCAISLDRYIHIKKpLKYERWMTTRRALVVIASVWILSALISFLPIhLGWHRLSQDEIKgLNHASNPKPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 181 YILFCTTVFSVI---------LMAIVILYARIYALVRTRSRKL--------VFRKVANG-----RGSNKSSEKSMALlkT 238
Cdd:cd15065  160 CALDLNPTYAVVsslisfyipCLVMLLIYSRLYLYARKHVVNIksqklpseSGSKFQVPslsskHNNQGVSDHKAAV--T 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 239 VIIVLSCFIACWAPLFILLLLDVACQTLTCSILYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15065  238 LGIIMGVFLICWLPFFIINIIAAFCKTCIPPKCFKI--LTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
29-303 3.09e-22

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 95.06  E-value: 3.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV----YTANILLS----GANTYKLtptqWFFRE 100
Cdd:cd15048    5 VLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVsmpfYIPYTLTGkwpfGKVFCKA----WLVVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 gsmFVALAASVFSLLAIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIAAILGGLPVMGWNC-----IDSINNCstVL 174
Cdd:cd15048   81 ---YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTkRRTVLLMALVWILAFLLYGPAIIGWDLwtgysIVPTGDC--EV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAYILFCTTV--FSVILMAIVILYARIYALVRTRSRKLVFRKV----ANGRGSNKSSEKSMALL-------KTVII 241
Cdd:cd15048  156 EFFDHFYFTFITSVleFFIPFISVSFFNLLIYLNIRKRSRRRPLRSVpilpASQNPSRARSQREQVKLrrdrkaaKSLAI 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982742395 242 VLSCFIACWAPLFILLLLDVACQTlTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15048  236 LVLVFLICWAPYTILTIIRSFCSG-SCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
38-303 5.02e-22

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 93.88  E-value: 5.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  38 IILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvyTANILLSGANTYKLTPTQWFFRE--GSMFVAL-----AAS 110
Cdd:cd15310   14 IVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLL-----VATLVMPWVVYLEVTGGVWNFSRicCDVFVTLdvmmcTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 111 VFSLLAIAIERHLTMLKMKLHNNGKTC----RVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPlyhkAYILFCT 186
Cdd:cd15310   89 ILNLCAISIDRYTAVVMPVHYQHGTGQsscrRVSLMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNP----DFVIYSS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 187 TV-FSVILMAIVILYARIYaLVRTRSRKLVfrkvangrgsnksseksmallKTVIIVLSCFIACWAPLFILLLLDVACQt 265
Cdd:cd15310  165 VVsFYLPFGVTLLVYVRIY-VVLLREKKAT---------------------QMLAIVLGAFIVCWLPFFLTHILNTHCQ- 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 982742395 266 lTCSI---LYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15310  222 -ACHVppeLYSA--TTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
30-303 2.82e-21

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 91.87  E-value: 2.82e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYT-ANILLSGANTYKLTPTQWFFR------EGS 102
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSlETIMIAVLNSGYLVISDQFIQhmdnvfDSM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 MFVALAASVFSLLAIAIERHLTML-KMKLHNNGKTCRVFMLISTVWFIAAIlgglpvmgwncidsinnCSTVLPLY--HK 179
Cdd:cd15352   86 ICISLVASICNLLAIAVDRYVTIFyALRYHSIMTVRKALVLIAVIWVVCIV-----------------CGIVFIVYseSK 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 AYILFCTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMALlkTVIIVLSCFIACWAPLFILLLL 259
Cdd:cd15352  149 TVIVCLITMFFAMLVLMATLYVHMFLFARLHVKRIAALPPAVDGAPQQRSCMKGAV--TITILLGVFIVCWAPFFLHLIL 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 982742395 260 DVACQTLTCSILYKAEW--FLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15352  227 IISCPHNPYCLCYTSHFntYLVLIMCNSVIDPLIYAFRSLEMRKTF 272
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
28-303 5.91e-21

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 91.01  E-value: 5.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV-VYTANILLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd15333    8 AVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSIlVMPISIVYTVTGTWTLGQVVCDIWLSSDITC 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIaAILGGLPVMGWNCIDSINNCST-VLPLYHKAYILF 184
Cdd:cd15333   88 CTASILHLCVIALDRYWAITDAVEYSKKRTPkRAAVMIALVWVI-SISISLPPFFWRQAKAEEEVSEcVVNTDHILYTVY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 CTT-VFSVILMAIVILYARIYALVRTRSRKLVfrkvangrgsnksseksmallKTVIIVLSCFIACWAPLFILLLLDVAC 263
Cdd:cd15333  167 STVgAFYIPTLLLIALYGRIYVEARARERKAT---------------------KTLGIILGAFIVCWLPFFIISLVLPIC 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 982742395 264 QTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15333  226 KDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
32-303 1.36e-20

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 89.96  E-value: 1.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCC---FIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTAN-ILLSGANTYKLTptqwFFREGSMFVAL 107
Cdd:cd15960    5 IALCVtgtVMACENAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANfVAIYVMNSEAVT----LCSAGLLLAAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTMLKMKLHNNGKTCR-VFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFCT 186
Cdd:cd15960   81 SASVCSLLAITVDRYLSLYNALTYHTERTLTfTYGLLALLWLTCIGIGLLPAMGWNCLRAPASCSVLRPVTKNNAAVLAV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 187 TvFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMAllkTVIIVLSCFIACWAPLFILLLldVACQTL 266
Cdd:cd15960  161 S-FLLLFALMMQLYLQICRIAFRHAQQIAVQHQFVNFCLASSTRKGVS---TLSLILATFAFCWVPFAVYSM--VADSSY 234
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 982742395 267 TCSILYkaewFLAL-AVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15960  235 PMIYTY----YLVLpAACNSVINPIIYAFRNPDIQKSL 268
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
30-301 4.45e-20

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 88.70  E-value: 4.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLL---AGVVYTANILLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLvsvSNLIETLFMLLLEHGVLVCRAPMLQHMDNVIDTM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLL----AIAIERHLTML-KMKLHNNGKTCRVFMLISTVWFIAAIlgglpvmgwncidsinnCSTVLPLYHKAY 181
Cdd:cd15351   86 ICSSVVSSLsflgAIAVDRYITIFyALRYHSIMTLQRAVNAIAGIWLASTV-----------------SSTLFIVYYNSN 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 -ILFCTTV-FSVILMAIVILYARIYALVRTRSRKLvfrKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLL 259
Cdd:cd15351  149 aVILCLIVfFLFMLVLMLVLYIHMFILACRHSQSI---SSQQRRQCPHQQTASLKGAITLTILLGIFFLCWGPFFLHLTL 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 982742395 260 DVACQT-LTCSILYKA-EWFLALAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15351  226 IVTCPThPFCLCYFKYfNLFLILIICNSIIDPLIYAFRSQELRK 269
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
28-303 7.44e-20

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 87.80  E-value: 7.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV-VYTANILLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd15061    3 ISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVlVLPLAIIRQLLGYWPLGSHLCDFWISLDVLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTMLKMKLHNNGKTCRV-FMLISTVWFIAAILGGLPVMG--WNCIDSINNCSTVlplYHKAYIL 183
Cdd:cd15061   83 CTASILNLCCISLDRYFAITYPLKYRTKRSRRLaITMILAVWVISLLITSPPLVGpsWHGRRGLGSCYYT---YDKGYRI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 184 FCTTV-FSVILMAIVILYARIYAlVRTRSRKLVfrkvangrgsnksseksmallKTVIIVLSCFIACWAPLFILLLLDVA 262
Cdd:cd15061  160 YSSMGsFFLPLLLMLFVYLRIFR-VIAKERKTA---------------------KTLAIVVGCFIVCWLPFFIMYLIEPF 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 982742395 263 CQTLTCSILYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15061  218 CDCQFSEALSTA--FTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
28-303 3.79e-19

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 86.74  E-value: 3.79e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV---YTANILLSGANTYKLTPTQ-WffreGSM 103
Cdd:cd15058    4 LLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLvvpLGATIVVTGKWQLGNFWCElW----TSV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FV-ALAASVFSLLAIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIAAILGGLPVM----------GWNCIDSINNCS 171
Cdd:cd15058   80 DVlCVTASIETLCVIAVDRYIAITRPLRYQVLLTkRRARVIVCVVWIVSALVSFVPIMnqwwrandpeANDCYQDPTCCD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVLplyHKAYILFCTTV-FSVILMAIVILYARIYaLVRTRSRKLV--------------------FRKVANGRGSNKSSE 230
Cdd:cd15058  160 FRT---NMAYAIASSVVsFYIPLLIMIFVYARVF-LIATRQLQLIdkrrlrfqsecpapqttspeGKRSSGRRPSRLTVV 235
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 231 KSMALLKTVIIVLSCFIACWAPLFILLLLDVACQTLTcsilyKAEWFLALAVL---NSAMNPLIYTlTSNEMRRAF 303
Cdd:cd15058  236 KEHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLP-----PGEVFLLLNWLgyiNSGLNPIIYC-RSPEFRTAF 305
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
29-303 8.06e-19

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 85.37  E-value: 8.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTA-NILLSGAntYKLTPTQWFFREGSMFVAL 107
Cdd:cd15068    5 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPfAITISTG--FCAACHGCLFIACFVLVLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTmLKMKLHNNG--KTCRVFMLISTVWFIAAILGGLPVMGWN--------------CIDSINNC- 170
Cdd:cd15068   83 QSSIFSLLAIAIDRYIA-IRIPLRYNGlvTGTRAKGIIAICWVLSFAIGLTPMLGWNncgqpkegknhsqgCGEGQVACl 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 171 -STVLPLYHKAYILFCTTVFsVILMAIVILYARIYALVRtRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIAC 249
Cdd:cd15068  162 fEDVVPMNYMVYFNFFACVL-VPLLLMLGVYLRIFLAAR-RQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 250 WAPLFIlllldVACQTLTCSILYKAE-WFLALAVL----NSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15068  240 WLPLHI-----INCFTFFCPDCSHAPlWLMYLAIVlshtNSVVNPFIYAYRIREFRQTF 293
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
30-303 2.07e-18

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 84.40  E-value: 2.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVccFIILENVLVLLTIWRTKKFHKPMY-YFIGNLALSDLLAGVvytanILLSGANTYKLTPTQWFFREGSMFVAL- 107
Cdd:cd15057    8 YLLVL--LTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAI-----LVMPWAAVNEVAGYWPFGSFCDVWVSFd 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 ----AASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVM-GWNCIDSIN----------NCS 171
Cdd:cd15057   81 imcsTASILNLCVISVDRYWAISSpFRYERRMTRRRAFIMIAVAWTLSALISFIPVQlGWHRADDTSealalyadpcQCD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVLplyHKAYILFCTTV-FSVILMAIVILYARIYALVRTRSRKL------VFRKVANGRGSNKSSEKSMALLKTVIIVLS 244
Cdd:cd15057  161 SSL---NRTYAISSSLIsFYIPVAIMIVTYTRIYRIARRQIRRIaaleraAQESTNPDSSLRSSLRRETKALKTLSIIMG 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982742395 245 CFIACWAPLFILLLLDVACQT----LTCSILYKAEWFLALAVLNSAMNPLIYTlTSNEMRRAF 303
Cdd:cd15057  238 VFVCCWLPFFILNCVLPFCDLrtaqFPCVPDTTFIVFVWLGWANSSLNPIIYA-FNADFRKAF 299
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-303 1.16e-17

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 82.09  E-value: 1.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVytaNILLSGANTYKLTptqwfFREG------- 101
Cdd:cd15197    5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLI---NVLTDIIWRITVE-----WRAGdfackvi 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 --SMFVALAASVFSLLAIAIER-HLTMLKMKLHNNGKTCRvfMLISTVWFIAAILG----------GLPVMGWNCIDSIN 168
Cdd:cd15197   77 ryLQVVVTYASTYVLVALSIDRyDAICHPMNFSQSGRQAR--VLICVAWILSALFSipmliifektGLSNGEVQCWILWP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 169 NcstvlPLYHKAYI-LFCTTVFSVILMAIVILYARIYALVRTRSRKLV--FRKVANGRGSNKSSEKSM---ALLKTV--- 239
Cdd:cd15197  155 E-----PWYWKVYMtIVAFLVFFIPATIISICYIIIVRTIWKKSKIQVtiNKAGLHDGSSRRSSSRGIiprAKIKTIkmt 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 240 IIVLSCFIACWAPLFILLLLDVACQT-LTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15197  230 FVIVTVFIICWSPYFVFDLLDVFGLLpRSKTKIAAATFIQSLAPLNSAINPLIYCLFSTHLCRPL 294
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
29-303 1.18e-17

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 81.83  E-value: 1.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIIL----ENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytaniLLSGANTYKLTPTQWFFREG--- 101
Cdd:cd15055    1 VLLYIVLSSISLltvlGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGL------LVMPFSMIRSIETCWYFGDTfck 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 ----SMFVALAASVFSLLAIAIERH-------LTMLKMKLHnngktcRVFMLISTVWFIAAILGGLPVMGWNCIDSI--- 167
Cdd:cd15055   75 lhssLDYILTSASIFNLVLIAIDRYvavcdplLYPTKITIR------RVKICICLCWFVSALYSSVLLYDNLNQPGLiry 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 168 NNC--STVLPLYHKAYI--LFCTTVFSVILMaiVILYARIYALVRT-----RSRKLVFRKVANGRGSNKSSEKSMAllKT 238
Cdd:cd15055  149 NSCygECVVVVNFIWGVvdLVLTFILPCTVM--IVLYMRIFVVARSqaraiRSHTAQVSLEGSSKKVSKKSERKAA--KT 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 239 VIIVLSCFIACWAPLFILLLLDVACQTLTCSIlykaEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15055  225 LGIVVGVFLLCWLPYYIVSLVDPYISTPSSVF----DVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
28-303 1.32e-17

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 81.90  E-value: 1.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCcfiilENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG-VVYTANILLSgantyklTPTQWFFRE------ 100
Cdd:cd15314    9 LISLVTVC-----GNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGgLVMPPSMVRS-------VETCWYFGDlfckih 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 GSMFVAL-AASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILG-GLPVMGWNCIDSINN---CSTVL 174
Cdd:cd15314   77 SSFDITLcTASILNLCFISIDRYYAVCQpLLYRSKITVRVVLVMILISWSVSALVGfGIIFLELNIKGIYYNhvaCEGGC 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAYILFCTTVFSVILMAIVIL--YARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMallKTVIIVLSCFIACWAP 252
Cdd:cd15314  157 LVFFSKVSSVVGSVFSFYIPAVIMLciYLKIFLVAQRQARSIQSARTKSGASSSKMERKAT---KTLAIVMGVFLLCWTP 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982742395 253 LFILLLLDVACQTLTCSILYkaEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15314  234 FFLCNIIDPFINYSIPPVLI--EVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
28-303 1.45e-17

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 81.32  E-value: 1.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLlagvvyTANILLSGANTYKLTPTQWFFreGSMFVAL 107
Cdd:cd15060    4 TILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADL------AVAIFVLPLNVAYFLLGKWLF--GIHLCQM 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 ---------AASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVMGWN-CIDSINNCSTVLPL 176
Cdd:cd15060   76 wltcdilccTASILNLCAIALDRYWAIHDPINYAQKRTLkRVLLMIVVVWALSALISVPPLIGWNdWPENFTETTPCTLT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 YHKAYILFCTT-VFSVILMAIVILYARIYALVrtrsrklvfrkvangrgsnkSSEKSMAllKTVIIVLSCFIACWAPLFI 255
Cdd:cd15060  156 EEKGYVIYSSSgSFFIPLLIMTIVYVKIFIAT--------------------SKERRAA--RTLGIIMGVFVVCWLPFFL 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 982742395 256 LLLLDVACQTltCSILYKAEWFLA-LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15060  214 MYVILPFCET--CSPSAKVVNFITwLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
30-303 1.75e-17

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 81.33  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFI-ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV----YTANILLsgANTYKLTPTQ---WFFREg 101
Cdd:cd15302    5 LITAILSIItVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLEsmpfYTVYVLN--GDYWPLGWVLcdlWLSVD- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 smFVALAASVFSLLAIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIAAILGGLPVMGWnciDSINNCSTVLPlYHKA 180
Cdd:cd15302   82 --YTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTpRKVLLIIAITWIIPALLFFISIFGW---QYFTGQGRSLP-EGEC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 181 YILFCT----------TVFSVILMAIVILYARIYalvrtrsrklvfrKVANgrgsnksseKSMALLKTVIIVLSCFIACW 250
Cdd:cd15302  156 YVQFMTdpyfnmgmyiGYYWTTLIVMLILYAGIY-------------RAAN---------RARKALRTITFILGAFVICW 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 251 APLFILLLLDVACQTLTC--SILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15302  214 TPYHILATIYGFCEAPPCvnETLYTISYYLCY--MNSPINPFCYALANQQFKKTF 266
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
28-303 1.87e-17

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 81.57  E-value: 1.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLS---------GANTYKLTPtqwfF 98
Cdd:cd14997    4 SVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVEtwarepwllGEFMCKLVP----F 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  99 REgsmFVALAASVFSLLAIAIERHLTM---LKMKLHNNGKtcRVFMLISTVWfIAAILGGLPVM--------GWNCIDSI 167
Cdd:cd14997   80 VE---LTVAHASVLTILAISFERYYAIchpLQAKYVCTKR--RALVIIALIW-LLALLTSSPVLfitefkeeDFNDGTPV 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 168 NNCST-VLPLYHKAYILFCTTVFSVILMAI-VILYARIyalvrtrSRKLVFRKVANGRGSNKSSEKSMALLKTVI----I 241
Cdd:cd14997  154 AVCRTpADTFWKVAYILSTIVVFFVVPLAIlSGLYSVI-------CRRLVGHPALESRRADAANRHTLRSRRQVVymliT 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 982742395 242 VLSCFIACWAP-----LFILLLLDVACQTLTCSILYKAEWFL-ALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14997  227 VVVLFFVCLLPfrvvtLWIIFAPDEDLQALGLEGYLNLLVFCrVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
26-303 2.64e-17

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 80.74  E-value: 2.64e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  26 ADSVVFIIVccFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvVYTANILLSGANTYKltpTQWFFREG--SM 103
Cdd:cd15321   10 AAAITFLIL--FTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADIL---VATLIIPFSLANELM---GYWYFRKTwcEI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVAL-----AASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLY 177
Cdd:cd15321   82 YLALdvlfcTSSIVHLCAISLDRYWSVSRAIEYNSKRTPrRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKLN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAYILFCTTV--FSVILMAIVILYARIYALVRTRSRKLVFrkvangrgsnksseksmallkTVIIVLSCFIACWAPLFI 255
Cdd:cd15321  162 EEAWYILSSSIgsFFAPCLIMILVYLRIYLIAKNREKRFTF---------------------VLAVVIGVFVLCWFPFFF 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 982742395 256 LLLLDVACQTLtCSILYKA-EWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15321  221 SYSLGAICPEL-CKVPHSLfQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
30-303 2.85e-17

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 80.44  E-value: 2.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFI-IVCCFIIL----ENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV----YTANILLSGANTYKLTPTQWFFRE 100
Cdd:cd15049    1 VLIcIATGSLSLvtvgGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVsmnlYTVYLVMGYWPLGPLLCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 gsmFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVMGWNCIDSI-----NNCSTvl 174
Cdd:cd15049   81 ---YVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPkRAILMIALAWVISFVLWAPAILGWQYFVGErtvpdGQCYI-- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAYILFCTTV--FSVILMAIVILYARIYalvRTRSRKlvfRKVAngrgsnksseksmallKTVIIVLSCFIACWAP 252
Cdd:cd15049  156 QFLDDPAITFGTAIaaFYLPVLVMTILYWRIY---RETARE---RKAA----------------RTLSAILLAFIITWTP 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982742395 253 LFILLLLDVACQTLTCSILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15049  214 YNILVLVSTFCAKCIPDTLWSFGYWLCY--INSTINPFCYALCNKTFRKTF 262
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
30-302 4.05e-17

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 80.45  E-value: 4.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFI-ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANtykltpTQWFFRE-------- 100
Cdd:cd15083    5 IFILIIGLIgVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFS------GRWIFGKtgcdmygf 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 -GSMFValAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWN--------CIDSINNC 170
Cdd:cd15083   79 sGGLFG--IMSINTLAAIAVDRYLVITRpMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSryvlegllTSCSFDYL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 171 STVlPLYHKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKLV-FRKVANGRGSNKSSEKSMALLKTVIIVLSC---F 246
Cdd:cd15083  157 SRD-DANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKeMAKRFSKSELSSPKARRQAEVKTAKIALLLvllF 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 247 IACWAPLFILLLLDVACQTLTCSILYKAeWFLALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15083  236 CLAWTPYAVVALIGQFGYLEVLTPLATA-IPAAFAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
26-303 1.48e-16

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 78.44  E-value: 1.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  26 ADSVVFIIVccFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvVYTANILLSGANTYKltpTQWFFREG--SM 103
Cdd:cd15323    4 AAVVGFLIV--FTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADIL---VATLVMPFSLANELM---GYWYFGQVwcNI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVAL-----AASVFSLLAIAIERHLTMLKMKLHNNGKTCR-VFMLISTVWFIAAILGGLPVMGWNcidsINNCSTVLPLY 177
Cdd:cd15323   76 YLALdvlfcTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRrVKAIIVTVWLISAVISFPPLISMY----RDPEGDVYPQC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 ----HKAYILF-CTTVFSVILMAIVILYARIYALVRTRSRKLVFrkvangrgsnksseksmallkTVIIVLSCFIACWAP 252
Cdd:cd15323  152 klndETWYILSsCIGSFFAPCLIMILVYIRIYRVAKAREKRFTF---------------------VLAVVMGVFVVCWFP 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 253 LFILLLLDVACQTlTCSI---LYKaeWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15323  211 FFFSYSLYGICRE-ACEVpepLFK--FFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
29-303 1.83e-16

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 78.64  E-value: 1.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytaniLLSGANTYKLTPTQWFFreGSMFVAL- 107
Cdd:cd15317    5 IVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGL------CVMPFSMIRTVETCWYF--GDLFCKFh 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 --------AASVFSLLAIAIERHLTMLKMKLHNNGKTCRV-FMLISTVWFIAAIL-GGLPVMGWN------CIDSINNCS 171
Cdd:cd15317   77 tgldlllcTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVaWRFIAIGWLVPGIYtFGLIYTGANdegleeYSSEISCVG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVLPLYHKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKLVfrkvANGRGSNKSSEKSMAL--------LKTVIIVL 243
Cdd:cd15317  157 GCQLLFNKIWVLLDFLTFFIPCLIMIGLYAKIFLVARRQARKIQ----NMEDKFRSSEENSSKAsasrerkaAKTLAIVM 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 244 SCFIACWAPLFILLLLDVACQTLTCSILYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15317  233 GIFLFCWLPYFIDTIVDEYSNFITPAIVFDA--VIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
28-303 1.92e-16

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 78.31  E-value: 1.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYtanILLSGANTYKltpTQWFFREGSMFVAL 107
Cdd:cd15063    4 LLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLV---LPFSAVNEVL---DVWIFGHTWCQIWL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 A-------ASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSI-------NNCS- 171
Cdd:cd15063   78 AvdvwmctASILNLCAISLDRYLAITRpIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGimdysgsSSLPc 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVLPLYHKAYILFCTT-VFSVILMAIVILYARIYALVRTrsrklvfrkvangrgsnkssEKSMAllKTVIIVLSCFIACW 250
Cdd:cd15063  158 TCELTNGRGYVIYSALgSFYIPMLVMLFFYFRIYRAARM--------------------ETKAA--KTVAIIVGCFIFCW 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982742395 251 APLFILLLLDVACQTLTCSILYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15063  216 LPFFTVYLVRAFCEDCIPPLLFSV--FFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
28-303 2.38e-16

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 77.74  E-value: 2.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFI-ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV-VYTANILLSGANTYKLTPTQWFFREGSMFV 105
Cdd:cd15052    3 AALLLLLLVIAtIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLlVMPLSILTELFGGVWPLPLVLCLLWVTLDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 AL-AASVFSLLAIAIERHLTMLKMKLHNNGKTCR-VFMLISTVWFIA-AILGGLPVMGWNCIDSI-NNCSTVLPLYHkaY 181
Cdd:cd15052   83 LFcTASIMHLCTISLDRYMAIRYPLRTRRNKSRTtVFLKIAIVWLISiGISSPIPVLGIIDTTNVlNNGTCVLFNPN--F 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 ILFCTTV-FSVILMAIVILYAR-IYALvrTRSRKLVfrkvangrgsnksseksmallKTVIIVLSCFIACWAPLFILLLL 259
Cdd:cd15052  161 VIYGSIVaFFIPLLIMVVTYALtIRLL--SNEQKAS---------------------KVLGIVFAVFVICWCPFFITNIL 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 982742395 260 DVACQTLTCSILYK-AEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15052  218 TGLCEECNCRISPWlLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
33-303 2.44e-16

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 78.05  E-value: 2.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  33 IVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVytaNILlsgaNTYKLTPTQWFFreGSMF-------- 104
Cdd:cd15196    9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALF---NVL----PQLIWDITYRFY--GGDLlcrlvkyl 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 --VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGW---NCIDSINNCSTVL--PLY 177
Cdd:cd15196   80 qvVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVLSLLLSIPQLFIFsyqEVGSGVYDCWATFepPWG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAYI-LFCTTVFSVILMAIVILYARIYalvrtrsrKLVFRkvangrgsnksseksmALLKTV---IIVLSCFIACWAPL 253
Cdd:cd15196  160 LRAYItWFTVAVFVVPLIILAFCYGRIC--------YVVWR----------------AKIKTVkltLVVVACYIVCWTPF 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 982742395 254 FILLLLDVACQT-------LTCSILykaewflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15196  216 FVVQMWAAWDPTapiegpaFVIIML--------LASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
29-303 2.99e-16

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 78.17  E-value: 2.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFI--ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLtPTQWFFREGSMFVA 106
Cdd:cd14979    3 VTAIYVAIFVvgIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPW-AFGDGGCKLYYFLF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LA---ASVFSLLAIAIERHLTM---LKMKLHNNGKtcRVFMLISTVWFIAAILgGLPVMGWNCIDSINNC---------- 170
Cdd:cd14979   82 EActyATVLTIVALSVERYVAIchpLKAKTLVTKR--RVKRFILAIWLVSILC-AIPILFLMGIQYLNGPlpgpvpdsav 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 171 -------STVLPLYHKAYILFcttvFSVILMAIVILYARIYALVRTR-----SRKLVFRKVANGRGSNKSSEKSMALLKT 238
Cdd:cd14979  159 ctlvvdrSTFKYVFQVSTFIF----FVLPMFVISILYFRIGVKLRSMrnikkGTRAQGTRNVELSLSQQARRQVVKMLGA 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 239 VIIVlscFIACWAPLFILLLLDVAC--QTLTCSILYKAEWFLA--LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14979  235 VVIA---FFVCWLPFHAQRLMFSYAskEDTFLFDFYQYLYPISgiLFYLSSAINPILYNLMSSRFRVAF 300
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
30-303 4.09e-16

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 77.67  E-value: 4.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFI-IVCCFIILENVLVLLTIWRTKKFHKPMYYF-IGNLALSDLLAGV----VYTANILLSGANTYKLtptQWFFRE--- 100
Cdd:cd14980    5 IFIwIIGILALIGNILVIIWHISSKKKKKKVPKLlIINLAIADFLMGIylliIAIADQYYRGRYAQYS---EEWLRSppc 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 --GSMFVALAA--SVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVM------GWNCIDSINnc 170
Cdd:cd14980   82 llACFLVSLSSlmSVLMMLLITLDRYICIVYPFSNKRLSYKSAKIILILGWLFSIIFAAIPILysinqpGDNRLYGYS-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 171 STVLPL-----YHKAYILFCTTVFSVILMAIVILYARIYALVRtRSRKLVFRKVANgrgsnksSEKSMALlKTVIIVLSC 245
Cdd:cd14980  160 SICMPSnvsnpYYRGWLIAYLLLTFIAWIIICILYILIFISVR-KSRKSARRSSSK-------RDKRIAI-RLALILITD 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 246 FIaCWAPLFILLLLDVACQTLTCSILYKaewFLALAVL--NSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14980  231 LI-CWLPYYIVIFSGLLTSTEIDIHVLQ---FIAILALplNSAINPYLYTLTTPTFKRDF 286
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
38-303 6.90e-16

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 77.25  E-value: 6.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  38 IILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYT---ANILLSGANTYKLTPTQWFFREGSMFVAlaASVFSL 114
Cdd:cd15959   14 IVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVppgATILLTGHWPLGTTVCELWTSVDVLCVT--ASIETL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 115 LAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMG--W---------NCIDSINNCSTVLPLyhkAYI 182
Cdd:cd15959   92 CAIAVDRYLAITNpLRYEALVTKRRARTAVCLVWAISAAISFLPIMNqwWrdgadeeaqRCYDNPRCCDFVTNM---PYA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 183 LFCTTV-FSVILMAIVILYARIYAlVRTRSRKLVFRKVANGRGSNKSSEKS-----------MAL-----LKTVIIVLSC 245
Cdd:cd15959  169 IVSSTVsFYVPLLVMIFVYVRVFV-VATRQVRLIRKDKVRFPPEESPPAESrpacgrrpsrlLAIkehkaLKTLGIIMGT 247
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 246 FIACWAPLFILLLLDVACQTLTCSILYKA-EWflaLAVLNSAMNPLIYTlTSNEMRRAF 303
Cdd:cd15959  248 FTLCWLPFFVANIIKVFCRSLVPDPAFLFlNW---LGYANSAFNPIIYC-RSPDFRSAF 302
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
37-303 7.47e-16

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 76.47  E-value: 7.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  37 FIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvYTANILLSGANTYKLtpTQWFFreGSMF---------VAL 107
Cdd:cd15326   13 FAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLL----LSFTVLPFSATLEIL--GYWVF--GRIFcdiwaavdvLCC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTmLKMKLHNNGKTCR--VFMLISTVWFIAAILGGLPVMGWNciDSINNCSTVLPLYHKA-YILF 184
Cdd:cd15326   85 TASILSLCAISIDRYIG-VRHSLQYPTIVTRkrAILALLGVWVLSTVISIGPLLGWK--EPAPPDDKVCEITEEPfYALF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 CT-TVFSVILMAIVILYARIYALVRTRSRklvfrkvangrgsnkssEKSMAllKTVIIVLSCFIACWAPLFILLLLDVAC 263
Cdd:cd15326  162 SSlGSFYIPLIVILVMYCRVYIVALKFSR-----------------EKKAA--KTLGIVVGMFILCWLPFFIALPLGSLF 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 982742395 264 QTLT-CSILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15326  223 SHLKpPETLFKIIFWLGY--FNSCLNPIIYPCSSKEFKRAF 261
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
33-303 1.28e-15

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 75.93  E-value: 1.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  33 IVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG-VVYTANILLSGANTYKLTPTQWFFREGSMFVALAASV 111
Cdd:cd15050    9 TISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGaVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 112 FSLLAIAIERHLTM---LKMKLHNNGKtcRVFMLISTVWFIAaILGGLPVMGWNCIDS-------INNCSTVLPLYHKAY 181
Cdd:cd15050   89 FSLFILCIDRYRSVqqpLKYLKYRTKT--RASLMISGAWLLS-FLWVIPILGWHHFARggervvlEDKCETDFHDVTWFK 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 ILFCTTVFSVILMAIVILYARIYALVRTRsrklvfRKVANGRGsnksseksmallktviIVLSCFIACWAPLFILLLLDV 261
Cdd:cd15050  166 VLTAILNFYIPSLLMLWFYAKIFKAVNRE------RKAAKQLG----------------FIMAAFILCWIPYFILFMVIA 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 982742395 262 ACQTLTCSILYKAEwfLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15050  224 FCKNCCNENLHMFT--IWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
30-303 1.81e-15

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 75.70  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFI-IVCCFIILENVLVLltIWRTKKFHKPMYY--FIGNLALSDLLAGV----VYTANILLSGanTYKLTPTQWffREGS 102
Cdd:cd15137    5 VFIwVVGIIALLGNLFVL--IWRLKYKEENKVHsfLIKNLAIADFLMGVylliIASVDLYYRG--VYIKHDEEW--RSSW 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 M-----FVALA---ASVFSLLAIAIERHLtMLKMKLHNNGKT-CRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTV 173
Cdd:cd15137   79 LctfagFLATLsseVSVLILTLITLDRFI-CIVFPFSGRRLGlRRAIIVLACIWLIGLLLAVLPLLPWDYFGNFYGRSGV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 174 -LPLY-HKAYIL---FCTTVF----SVILMAIVILYARIYALVRtRSRKLVfrkvangRGSNKSSEKSMALlKTVIIVLS 244
Cdd:cd15137  158 cLPLHiTDERPAgweYSVFVFlglnFLAFVFILLSYIAMFISIR-RTRKAA-------ASRKSKRDMAVAK-RFFLIVLT 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982742395 245 CFiACWAPLFILLLLDVACQTLTCSIlykaewFLALAV----LNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15137  229 DF-LCWIPIIVIGILALSGVPIPGEV------YAWVAVfvlpINSALNPILYTLSTPKFRKKL 284
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
28-292 2.68e-15

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 75.49  E-value: 2.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIivccFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV-YTANILLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd14986    8 GVLFV----FTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFtVLTQIIWEATGEWVAGDVLCRIVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTMLKmKLHNNGKTCRVFMLISTVWFIAAILGG----------LPVMGWNCIDSINNcstvlPL 176
Cdd:cd14986   84 LFASTYILVSMSLDRYQAIVK-PMSSLKPRKRARLMIVVAWVLSFLFSIpqlvifvereLGDGVHQCWSSFYT-----PW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 YHKAYILFCTT-VFSVILMAIVILYARIYALVRTRSR----------KLVFRKVANGRGSNK--SSEKSMALLKTVIIVL 243
Cdd:cd14986  158 QRKVYITWLATyVFVIPLIILSYCYGRILRTIWIRSRqktdrpiaptAMSCRSVSCVSSRVSliSRAKIKTIKMTLVIIL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982742395 244 ScFIACWAPLFILLLLDV--ACQTLTCSILYKAEwflALAVLNSAMNPLIY 292
Cdd:cd14986  238 A-FILCWTPYFIVQLLDVyaGMQQLENDAYVVSE---TLASLNSALNPLIY 284
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
37-303 4.41e-15

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 74.21  E-value: 4.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  37 FIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvVYTANILLSGANTYKltpTQWFFREGSMFVALA-------A 109
Cdd:cd15322   13 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL---VATLVIPFSLANEVM---GYWYFGKVWCEIYLAldvlfctS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 110 SVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILF-CTT 187
Cdd:cd15322   87 SIVHLCAISLDRYWSITQAIEYNLKRTPrRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGPICKINDEKWYIISsCIG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 188 VFSVILMAIVILYARIYALVRTRSRKLVFrkvangrgsnksseksmallkTVIIVLSCFIACWAPLFILLLLDVACQTLT 267
Cdd:cd15322  167 SFFAPCLIMVLVYIRIYQIAKNREKRFTF---------------------VLAVVIGVFVICWFPFFFTYTLTAVCDCSV 225
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 982742395 268 CSILYKaeWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15322  226 PETLFK--FFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
28-303 4.58e-15

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 74.94  E-value: 4.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG---VVYTANILLSGantykltptQWFFreGSMF 104
Cdd:cd15958    4 SLLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGllvVPFGATLVVRG---------RWLY--GSFF 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VAL---------AASVFSLLAIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIAAILGGLPV-MGW---------NCI 164
Cdd:cd15958   73 CELwtsvdvlcvTASIETLCVIAIDRYLAITSPFRYQSLLTrARAKGIVCTVWAISALVSFLPImMHWwrdeddqalKCY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 165 DSINNCSTVLplyHKAYILFCTTV-FSVILMAIVILYARIYALVRTRSRKL-------VFRKVANGRGSNKSSEKSMAL- 235
Cdd:cd15958  153 EDPGCCDFVT---NRAYAIASSIIsFYIPLLIMIFVYLRVYREAKKQIKKIdkcegrfHNTLTGLGRKCKRRPSRILALr 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982742395 236 ----LKTVIIVLSCFIACWAPLFILLLLDVACQTLTCSILYKAewFLALAVLNSAMNPLIYTlTSNEMRRAF 303
Cdd:cd15958  230 eqkaLKTLGIIMGVFTLCWLPFFLVNVVNVFNRELVPDWLFVF--FNWLGYANSAFNPIIYC-RSPDFRKAF 298
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
28-307 8.61e-15

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 73.71  E-value: 8.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILlsganTYKLTPTQWFFREGSMF--- 104
Cdd:cd15295    4 LFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYI-----PYTLTNRWDFGRGLCVFwlv 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 ---VALAASVFSLLAIAIERHLTMLKMKLHNN--GKTCRVFMLISTVWFIAAILGGLPVMGWNCiDSINNCSTVLPLYHK 179
Cdd:cd15295   79 idyLLCTASVYNIVLISYDRYQSVSNAVSYRNqqTATLRIVTQMVAVWVLAFLVHGPAILVSDS-WKTEDGECEPEFFSN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 AYILFCTTVFSVILMAIVILYARIYALVRTRSRkLVFRKVAngrgsnksseKSMAllktviIVLSCFIACWAPLFILLLL 259
Cdd:cd15295  158 WYILAITSVLEFLVPVILVAYFNTQIYWSLWKR-LRDRKLA----------KSLA------IILGTFAICWAPYSLFTII 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 982742395 260 DVACQTLTCSILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAFIKML 307
Cdd:cd15295  221 RAACEKHRGSPWYNFAFWLQW--FNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
29-303 9.35e-15

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 73.90  E-value: 9.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFI----ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMF 104
Cdd:cd15134    1 IPITIIYGIIfvtgVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPWVFGEVFCKLRAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALA--ASVFSLLAIAIERHLTML-KMKLHNNGKTCRVFMLISTVWFIAAILgGLPVMGWNCIDSINNCSTVLPLYHKAY 181
Cdd:cd15134   81 SEMSsyASVLTITAFSVERYLAIChPLRSHTMSKLSRAIRIIIAIWIIAFVC-ALPFAIQTRIVYLEYPPTSGEALEESA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 I--------------LFCTTVFSVILM-AIVILYARIYalVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCF 246
Cdd:cd15134  160 FcamlneippitpvfQLSTFLFFIIPMiAIIVLYVLIG--LQLRRSTLLRRGQRSVSGGRRSSQSRRTVLRMLVAVVVAF 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 982742395 247 IACWAPLFILLLLDVACQTLTCSILYKAEWFLALA----VLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15134  238 FICWAPFHAQRLLTVYAKNMTPPYLFINRILFYISgvlyYVSSTVNPILYNVMSAKYRQAF 298
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
39-303 9.88e-15

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 73.09  E-value: 9.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytanILLSGANTYKLTpTQWFFREGS--MFVAL-----AASV 111
Cdd:cd15330   15 IFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSV-----LVLPMAALYQVL-NKWTLGQVTcdLFIALdvlccTSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 112 FSLLAIAIERHLTMLKMKLHNNGKTCR-VFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFCT-TVF 189
Cdd:cd15330   89 LHLCAIALDRYWAITDPIDYVNKRTPRrAAVLISLTWLIGFSISIPPMLGWRTPEDRSDPDACTISKDPGYTIYSTfGAF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 190 SVILMAIVILYARIYAlVRTRSRKLVfrkvangrgsnksseksmallKTVIIVLSCFIACWAPLFILLLLDVACQTlTCs 269
Cdd:cd15330  169 YIPLILMLVLYGRIFK-AAARERKTV---------------------KTLGIIMGTFILCWLPFFIVALVLPFCES-TC- 224
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 982742395 270 ilYKAEWFLA----LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15330  225 --HMPELLGAiinwLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
29-303 1.11e-14

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 72.91  E-value: 1.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVytaniLLSGANTYKLTpTQWFFreGSMF---- 104
Cdd:cd15062    5 VALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFT-----VLPFSATLEVL-GYWAF--GRIFcdvw 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 -----VALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNciDSINNCSTVLPLY- 177
Cdd:cd15062   77 aavdvLCCTASIMSLCVISVDRYIGVRYpLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWK--EPAPADEQACGVNe 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAYILFCTT-VFSVILMAIVILYARIYALVRTRSRklvfrkvangrgsnkssEKSMAllKTVIIVLSCFIACWAPLFIL 256
Cdd:cd15062  155 EPGYVLFSSLgSFYLPLAIILVMYCRVYVVAFKFSR-----------------EKKAA--KTLGIVVGAFVLCWFPFFVV 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 982742395 257 LLLDVACQTLTCS-ILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15062  216 LPLGSLFSTLKPPePVFKVVFWLGY--FNSCLNPIIYPCSSREFKRAF 261
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
28-301 1.19e-14

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 73.26  E-value: 1.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLL--AGVVYTANILLSGAntykltptQWFFREGSMFV 105
Cdd:cd15088    4 PSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLfmLGMPFLIHQFAIDG--------QWYFGEVMCKI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 ALA-------ASVFSLLAIAIERHL------------TMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLpvmgwnciDS 166
Cdd:cd15088   76 ITAldannqfTSTYILTAMSVDRYLavvhpirstkyrTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFP--------DG 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 167 INNCSTVLP----LYHKAYILFCTTvFSVILMAIVILYARIyaLVRTrsrklvFRKVANGRGSNKSSeKSMALLKTVIIV 242
Cdd:cd15088  148 TTFCYVSLPspddLYWFTIYHFILG-FAVPLVVITVCYILI--LHRL------ARGVAPGNQSHGSS-RTKRVTKMVILI 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 243 LSCFIACWAPLFILLLLDVACQTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15088  218 VVVFIVCWLPFHVVQLVNLAMNRPTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
29-292 1.19e-14

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 73.27  E-value: 1.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFI----ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV-VYTANILLS-GANTYKLTptqWFFREGS 102
Cdd:cd15070    1 VTYISIEILIglcaVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVlVIPLAIVVSlGVTIHFYS---CLFMSCL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 MFVALAASVFSLLAIAIERHLTM-LKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCST--------- 172
Cdd:cd15070   78 LVVFTHASIMSLLAIAVDRYLRVkLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTtplqcqfts 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 173 VLPLYHKAYILFCTTVFsVILMAIVILYARIYALVRTRsrklVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAP 252
Cdd:cd15070  158 VMRMDYMVYFSFFTWIL-IPLVIMCALYVDIFYIIRNK----LSQNATGFRETGAFYGREFKTAKSLALVLFLFAVCWLP 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 982742395 253 LFILLLLDVACQTLTCSILYKAewfLALAVLNSAMNPLIY 292
Cdd:cd15070  233 LSIINCVVYFNPKVPKIALYLG---ILLSHANSMMNPIVY 269
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
28-303 1.28e-14

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 73.06  E-value: 1.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV-VYTANILLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd15334    4 SLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVlVMPFSIMYIVKETWIMGQVVCDIWLSVDITC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIaAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFC 185
Cdd:cd15334   84 CTCSILHLSAIALDRYRAITDAVEYARKRTpKHAGIMIAVVWII-SIFISMPPLFWRHQTTSREDECIIKHDHIVFTIYS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 186 T-TVFSVILMAIVILYARIYAlVRTRSRKLVFrkvangrgsnksseksmallkTVIIVLSCFIACWAPLFILLLLDVACQ 264
Cdd:cd15334  163 TfGAFYIPLALILILYYKIYR-AATRERKAAT---------------------TLGLILGAFVICWLPFFVKEVIVNTCD 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 982742395 265 tlTCSILYKAEWFLA-LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15334  221 --SCYISEEMSNFLTwLGYINSLINPLIYTIFNEDFKKAF 258
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
29-303 1.31e-14

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 73.00  E-value: 1.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvyTANILLSGANTYKLTpTQWFFreGSMFVAL- 107
Cdd:cd15325    5 VILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLL-----LTSTVLPFSAIFEIL-GYWAF--GRVFCNIw 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 --------AASVFSLLAIAIERHLTM-LKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNciDSINNCSTVLPLYH 178
Cdd:cd15325   77 aavdvlccTASIMSLCIISIDRYIGVsYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWK--EPAPEDETICQITE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 K-AYILFCTT-VFSVILMAIVILYARIYALVRTRSRklvfrkvangrgsnkssEKSMAllKTVIIVLSCFIACWAPLFIL 256
Cdd:cd15325  155 EpGYALFSALgSFYLPLAIILVMYCRVYVVALKFSR-----------------EKKAA--KTLGIVVGCFVLCWLPFFLV 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 982742395 257 LLLDVACQTLTCS-ILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15325  216 MPIGSIFPAYKPSdTVFKITFWLGY--FNSCINPIIYPCSSQEFKKAF 261
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
28-303 2.07e-14

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 72.26  E-value: 2.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV-VYTANILLSGANTYKLTptqWFFREGSMFVA 106
Cdd:cd15335    4 VLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVlVMPLSITYIVMDTWTLG---YFICEIWLSVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 L---AASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIaAILGGLPVMGWNCIDSINNCSTVLPLY-HKAY 181
Cdd:cd15335   81 MtccTCSILHLCVIALDRYWAITDAIEYARKRTAkRAGLMILTVWTI-SIFISIPPLFWRNHHDANIPSQCIIQHdHVIY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 ILFCTT-VFSVILMAIVILYARIYAlVRTRSRKLVfrkvangrgsnksseksmallKTVIIVLSCFIACWAPLFILLLLd 260
Cdd:cd15335  160 TIYSTFgAFYIPLTLILILYYRIYH-AASRERKAA---------------------RILGLILGAFILSWLPFFIKELI- 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 982742395 261 VACQTLTCSILYkAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15335  217 VGLSVMTVSPEV-ADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
28-303 3.72e-14

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 72.23  E-value: 3.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCfiILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGantyklTPTQWFFreGSMF--- 104
Cdd:cd15980    6 SYLLIFLLC--MMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDN------IIAGWPF--GSTVckm 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 ------VALAASVFSLLAIAIERHLTML---KMKLhnngKTCRVFMLISTVWFIA-AILGGLPVMGW-----NCIDSINN 169
Cdd:cd15980   76 sgmvqgISVSASVFTLVAIAVDRFRCIVypfKQKL----TISTAVVIIVIIWVLAiAIMCPSAVMLHvqeekNYRVVLGS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 170 CSTVLPLY--------HKAYILFCTTVFSVILMA----IVILYARIYALVRTRSRKLVFRKVANGRGSnkSSEKSMALLK 237
Cdd:cd15980  152 QNKTSPVYwcredwpnQEMRKIYTTVLFANIYLAplslIVIMYARIGITLFKTAMPHTGKHNQEQRHV--VSRKKQKVIK 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982742395 238 TVIIVLSCFIACWAPLFILLLL-------DVACQTLTCSILYKAEWflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15980  230 MLLIVALLFILSWLPLWTLMMLsdyanlsPNQLQIINIYIYPFAHW---LAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
32-303 4.33e-14

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 71.89  E-value: 4.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV---YTANILLSGANTYKltptQWFFREGSMFVALA 108
Cdd:cd15069    8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFaipFAITISLGFCTDFH----SCLFLACFVLVLTQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVFSLLAIAIERHLTM---LKMKLHNNGKTCRvfMLISTVWFIAAILGGLPVMGWNCIDSINNCST------------- 172
Cdd:cd15069   84 SSIFSLLAVAVDRYLAIkvpLRYKSLVTGKRAR--GVIAVLWVLAFGIGLTPFLGWNKAMSATNNSTnpadhgtnhsccl 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 173 -------VLPLYHKAYILFCTTVFSVILMAIVIlYARIYaLVRTRSrklvFRKVANGRGSNKSSEKSMALLKTVIIVLSC 245
Cdd:cd15069  162 isclfenVVPMSYMVYFNFFGCVLPPLLIMLVI-YIKIF-LVACRQ----LQRTELMDHSRTTLQREIHAAKSLAIIVGI 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 246 FIACWAPLfilllldvacQTLTCSILY-------KAEWFLALAVL----NSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15069  236 FALCWLPV----------HILNCITLFqpefsksKPKWAMNVAILlshaNSVVNPIVYAYRNRDFRYTF 294
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
33-309 4.58e-14

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 71.52  E-value: 4.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  33 IVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV----YTANILLSGANTYKLTPTQWFFREgsmFVALA 108
Cdd:cd15299   12 ILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVIsmnlFTTYIIMNRWALGNLACDLWLSID---YVASN 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVMGWNCID---SINNCSTVLPLYHKAYILF 184
Cdd:cd15299   89 ASVMNLLVISFDRYFSITRPLTYRAKRTTkRAGVMIGLAWVISFVLWAPAILFWQYFVgkrTVPPDECFIQFLSEPIITF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 CTTV--FSVILMAIVILYARIYalvrtrsrklvfrkvangrgsnKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVA 262
Cdd:cd15299  169 GTAIaaFYLPVTIMTILYWRIY----------------------KETIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTF 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 982742395 263 CQTLTCSILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAFIKMLNC 309
Cdd:cd15299  227 CDSCIPKTYWNLGYWLCY--INSTVNPVCYALCNKTFRTTFKMLLLC 271
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
28-307 4.73e-14

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 71.51  E-value: 4.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIV-CCFIILENVLVLLTIWRTKKFHK--PMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWF--FREGS 102
Cdd:cd14981    3 SPAPPALmFVFGVLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDGGQPLcdYFGFM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 MFVALAASVFSLLAIAIERHLTMLKMKLHNN-GKTCRVFMLISTVWFIAAILGGLPVMG-----------WNCIDSINNC 170
Cdd:cd14981   83 MSFFGLSSLLIVCAMAVERFLAITHPFFYNShVKKRRARLMLGAVWAFALLIASLPLLGlgsyvlqypgtWCFLDFYSKN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 171 STvlplyHKAY-ILFCTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCfiAC 249
Cdd:cd14981  163 TG-----DAAYaYLYSILGLLILLVTLLCNLLVIITLLRMRRRKKRHRRSRRSARRQKRNEIQMVVLLLAITVVFS--VC 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 250 WAPLFILLLLDvacQTLTCSILYKAEW-FLALAVLNSAMNPLIYTLtsneMRRAFIKML 307
Cdd:cd14981  236 WLPLMIRVLIN---ATGDSEKNGKTDLlAVRMASWNQILDPWVYIL----LRKEVLRRL 287
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
28-303 1.42e-13

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 70.02  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV---YTANILLSGantykltptqWFFREGSMF 104
Cdd:cd14970    4 PAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGlpfLATSYLLGY----------WPFGEVMCK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALA-------ASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLIS-TVWFIAAILgGLPVM---GWNCIDSIN-NCST 172
Cdd:cd14970   74 IVLSvdaynmfTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSlCVWALSLVL-GLPVIifaRTLQEEGGTiSCNL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 173 VLP----LYHKAYILFCTTV-FSVILMAIVILYARIyaLVRTRSRKLVFrkvangRGSNKSSEKSMALL-KTVIIVLSCF 246
Cdd:cd14970  153 QWPdppdYWGRVFTIYTFVLgFAVPLLVITVCYSLI--IRRLRSSRNLS------TSGAREKRRARRKVtRLVLVVVAVF 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 247 IACWAPLFIL---LLLDVACQTLTCSILYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14970  225 VVCWLPFHVFqivRLLIDPPETLTVVGVFLF--CIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
29-303 1.45e-13

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 69.90  E-value: 1.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFfregSMFVAL- 107
Cdd:cd15324    5 LVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWC----AFYLALd 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 ----AASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVM-----GWNCIdsINNcstvlply 177
Cdd:cd15324   81 vlfcTSSIVHLCAISLDRYWSVTKAVSYNLKRTPkRIKRMIAVVWVISAVISFPPLLmtkhdEWECL--LND-------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAYILF-CTTVFSVILMAIVILYARIYALVRTRSRKLVFrkvangrgsnksseksmallkTVIIVLSCFIACWAPLFIL 256
Cdd:cd15324  151 ETWYILSsCTVSFFAPGLIMILVYCKIYRVAKMREKRFTF---------------------VLAVVMGVFVLCWFPFFFT 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 982742395 257 LLLDVACQTlTCSI---LYKaeWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15324  210 YSLHAVCRK-RCGIpdaLFN--LFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
29-303 1.45e-13

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 70.00  E-value: 1.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIllsganTYKLTPTQWFFREGS------ 102
Cdd:cd15001    4 IVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLK------TAEYFSPTWSLGAFLckavay 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 -MFVALAASVFSLLAIAIERHLTML-KMK---LHNNGKTCRVFMLIstvWFIAAILG-------GLPVMGWNCIDSINNC 170
Cdd:cd15001   78 lQLLSFICSVLTLTAISIERYYVILhPMKaksFCTIGRARKVALLI---WILSAILAspvlfgqGLVRYESENGVTVYHC 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 171 -----STVLPLYHKAYILFCTTVFSVILMaiVILYARiyalvrtRSRKLVfrkvangrgsnksseksmalLKTVIIVLSC 245
Cdd:cd15001  155 qkawpSTLYSRLYVVYLAIVIFFIPLIVM--TFAYAR-------DTRKQV--------------------IKMLISVVVL 205
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 982742395 246 FIACWAPLFILLLL---DVACQTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15001  206 FAVCWGPLLIDNLLvsfDVISTLHTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
28-303 3.04e-13

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 69.17  E-value: 3.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVyTANILLsganTYKLTpTQWFFRE------- 100
Cdd:cd15203    4 ILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLV-SLPFTL----IYTLT-KNWPFGSilcklvp 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 ----GSMFValaaSVFSLLAIAIERHLTMLKmKLHNNGKTCRVFMLISTVWFIAAILgGLP---------VMGWNCIDSI 167
Cdd:cd15203   78 slqgVSIFV----STLTLTAIAIDRYQLIVY-PTRPRMSKRHALLIIALIWILSLLL-SLPlaifqelsdVPIEILPYCG 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 168 NNCSTVLPL--YHKAYILFCTTVFSVI-LMAIVILYARIYALVRTRSRKlvfrkvANGRGSNKSSEKSMALLKT------ 238
Cdd:cd15203  152 YFCTESWPSssSRLIYTISVLVLQFVIpLLIISFCYFRISLKLRKRVKK------KRGKRTLSSRRRRSELRRKrrtnrl 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982742395 239 -VIIVLsCFIACWAPL--------FILLLLDVACQTLTCSILykaewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15203  226 lIAMVV-VFAVCWLPLnlfnllrdFEPLPQIDGRHFYLIFLI-----CHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
29-303 4.18e-13

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 68.86  E-value: 4.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLL--------AGVVYTANILLSGANTYKLTptqWFFre 100
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLfvvfcvpfTATDYVLPTWPFGDVWCKIV---QYL-- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 gsMFVALAASVFSLLAIAIERHLTML----KMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCST---- 172
Cdd:cd15096   80 --VYVTAYASVYTLVLMSLDRYLAVVhpitSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEAYSYctfl 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 173 --VLPLYHKAYILFCTTVFSVILMAIVILYARIYalvrtrsRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACW 250
Cdd:cd15096  158 teVGTAAQTFFTSFFLFSYLIPLTLICVLYMLML-------RRLRRQKSPGGRRSAESQRGKRRVTRLVVVVVVVFAICW 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 251 APLFILLLLDVACQtLTCSILYKAEWFLA--LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15096  231 LPIHIILLLKYYGV-LPETVLYVVIQILSncLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
29-303 5.66e-13

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 68.61  E-value: 5.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCcfiILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV--------YTANILLSGANTYKLTPtqwFFRe 100
Cdd:cd14992    8 VVIILVS---VVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFctpfnftyVVSLSWEYGHFLCKIVN---YLR- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 gsmFVALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILG-------GLPVMGWNCIDSINNCST 172
Cdd:cd14992   81 ---TVSVYASSLTLTAIAFDRYFAIIHpLKPRHRQSYTTTVIIIITIWVVSLLLAipqlyyaTTEVLFSVKNQEKIFCCQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 173 VLP----LYHKAYILFCTTVFSVI-LMAIVILYARIyalvrtrSRKLVFRKVANGRGSNKSSEKSMALLKTV---IIVLS 244
Cdd:cd14992  158 IPPvdnkTYEKVYFLLIFVVIFVLpLIVMTLAYARI-------SRELWFRKVPGFSIKEVERKRLKCKRRVIkmlVCVVV 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982742395 245 CFIACWAPLFILLLL-----DVACQTLTCSILYKAEWflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14992  231 LFVICWLPFHLFFLLrdffpLIMKEKHTLQVYYFLHW---IAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
38-302 7.07e-13

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 67.96  E-value: 7.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  38 IILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGvvytanILLSGANTYKLTPTQWFFreGSMFVAL---------A 108
Cdd:cd15318   14 IVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLG------LTVLPFSTIRSVESCWYF--GDSFCRLhtcldtlfcL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVFSLLAIAIERHLTMLKMKLHNNGKTCRV-FMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLP-------LYHKA 180
Cdd:cd15318   86 TSIFHLCFISIDRHCAICDPLLYPSKFTIRVaCIFIAAGWLVPTVYTSVFLYTKAVEEGLAELLTSVPcvgscqlLYNKL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 181 YILFCTTVFSVILMAIVILYARIYaLVRTRSRKLVFRKVANGRGSNKSSEKSMallKTVIIVLSCFIACWAPLFILLLLD 260
Cdd:cd15318  166 WGWLNFPVFFIPCLIMIGLYVKIF-IVAKRQARAIASLLSDTNGASKRERKAA---KTLGIAVGVYLLCWLPFTIDTMVD 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 982742395 261 VACQTLTCSILYkaEWFLALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15318  242 SLLNFITPPLLF--DIIIWFAYFNSACNPLIYVFSYPWFRKA 281
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
28-303 1.09e-12

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 67.66  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRtKKFHKPMYYFIGNLALSDLLAGVVYTANILL-SGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd14978    4 GYVLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLLSALPLFLLpYIADYSSSFLSYFYAYFLPYIYP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LA-----ASVFSLLAIAIERHLT----MLKMKLHNNGKTCRVFMLIstvwFIAAILGGLPVMGWNCIDSINNCSTVLPLY 177
Cdd:cd14978   83 LAntfqtASVWLTVALTVERYIAvchpLKARTWCTPRRARRVILII----IIFSLLLNLPRFFEYEVVECENCNNNSYYY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKA------------YILFCTTVFSVIL--MAIVILYARIYALVRtRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVL 243
Cdd:cd14978  159 VIPtllrqnetyllkYYFWLYAIFVVLLpfILLLILNILLIRALR-KSKKRRRLLRRRRRLLSRSQRRERRTTIMLIAVV 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982742395 244 SCFIACWAPLFILLLLDVACQTLTCSILYKA--EWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14978  238 IVFLICNLPAGILNILEAIFGESFLSPIYQLlgDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
29-303 1.09e-12

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 67.24  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV---YTANILLSGAntykltptqWFFreGSMF- 104
Cdd:cd15327    5 VFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTvlpFSATLEVLGF---------WAF--GRVFc 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 --------VALAASVFSLLAIAIERHLTM-LKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWN----CIDSInnCS 171
Cdd:cd15327   74 diwaavdvLCCTASILSLCVISVDRYVGVkHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKepppPDESI--CS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVlplYHKAYILFCTTV-FSVILMAIVILYARIYALVRTRSRklvfrkvangrgsnkssEKSMAllKTVIIVLSCFIACW 250
Cdd:cd15327  152 IT---EEPGYALFSSLFsFYLPLMVILVMYFRVYVVALKFSR-----------------EKKAA--KTLAIVVGVFILCW 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 251 APLFILLLLDVACQTLTCS-ILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15327  210 FPFFFVLPLGSFFPALKPSeMVFKVIFWLGY--FNSCVNPIIYPCSSKEFKRAF 261
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
24-303 1.13e-12

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 67.40  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  24 LKADSVVFIIVCCfiILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV---YTANILLSGantykltptQWFFre 100
Cdd:cd15066    1 LKGFAMTLIILAA--IFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCamtFNASVEITG---------RWMF-- 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 GSMFVAL---------AASVFSLLAIAIERHLTM---LKMKLHNNGKtcRVFMLISTVWFIAAILGGLPV-MGW-----N 162
Cdd:cd15066   68 GYFMCDVwnsldvyfsTASILHLCCISVDRYYAIvqpLEYPSKMTKR--RVAIMLANVWISPALISFLPIfLGWytteeH 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 163 CIDSINNCSTVLPLYHKAYILFCTTV-FSVILMAIVILYARIYaLVRTRSRKLVfrkvangrgsnksseksmallKTVII 241
Cdd:cd15066  146 LQYRKTHPDQCEFVVNKIYALISSSVsFWIPCIVMIFTYYRIY-LEAKREHKAA---------------------KTLGI 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 982742395 242 VLSCFIACWAPLF----ILLLLDVACQT--LTCSILYkaeWflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15066  204 IMGAFILCWLPFFlwyvTTTLCGDACPYppILVSILF---W---IGYFNSTLNPLIYAYFNRDFREAF 265
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
29-294 1.16e-12

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 67.45  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQW-FFREGSMFVAL 107
Cdd:cd14964    3 IILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALcYLIYLLWYGAN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHlTMLKMKLHNNGKTCRVFML--ISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLY---HKAYI 182
Cdd:cd14964   83 LASIWTTLVLTYHRY-FALCGPLKYTRLSSPGKTRviILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLIcttIYLTW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 183 LFCTTVFSVILMAIVILYARIYALVRTRSRKLVFRkvangrgSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLD-- 260
Cdd:cd14964  162 GFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSA-------ASLNTDKNLKATKSLLILVITFLLCWLPFSIVFILHal 234
                        250       260       270
                 ....*....|....*....|....*....|....
gi 982742395 261 VACQTLTCsilYKAEWFLALAVLNSAMNPLIYTL 294
Cdd:cd14964  235 VAAGQGLN---LLSILANLLAVLASTLNPFIYCL 265
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
42-303 1.27e-12

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 67.56  E-value: 1.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  42 NVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG--VVYTANILLSGANTYKLTptqWFFREGSMFVALAASVFSLLAIAI 119
Cdd:cd15071   18 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGalVIPLAIIINIGPQTEFYS---CLMVACPVLILTQSSILALLAIAV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 120 ERHLtmlKMKLHNNGKTC----RVFMLISTVWFIAAILGGLPVMGWNCIDSINNC----------------STVLPLYHK 179
Cdd:cd15071   95 DRYL---RVKIPTRYKSVvtprRAAVAIAGCWILSFLVGLTPMFGWNNLNAVERAwaanssmgelvikcqfETVISMEYM 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 AYILFCTTVFSVILMAIVIlYARIYALVRTRSRKLVfrkVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILlll 259
Cdd:cd15071  172 VYFNFFVWVLPPLLLMLLI-YLEVFYLIRKQLNKKV---SSSSSDPQKYYGKELKIAKSLALILFLFALSWLPLHIL--- 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 982742395 260 dvACQTLTCSILYKAEWFLALAVL----NSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15071  245 --NCITLFCPSCKKPMILTYIAIFlthgNSAMNPIVYAFRIKKFRTTF 290
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
28-302 1.37e-12

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 67.44  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIiLENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANtykltpTQWFFRE-GSMFVA 106
Cdd:cd15336    5 SVILIIGITGM-LGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLH------KRWIFGEkGCELYA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVF------SLLAIAIERHLTMLK----MKLHNNGKTCRVFMLI---STVWFIAailgglPVMGWNCIDS---INNC 170
Cdd:cd15336   78 FCGALFgitsmiTLLAISLDRYLVITKplasIRWVSKKRAMIIILLVwlySLAWSLP------PLFGWSAYVPeglLTSC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 171 S----TVLPLYHKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKlVFRKVANGRGSNKSSEKSM----ALLKTVIIV 242
Cdd:cd15336  152 TwdymTFTPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGRE-VQKLGSQDRKEKAKQYQRMknewKMAKIAFVV 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 982742395 243 LSCFIACWAPLFILLLLDVACQTLTCSILYKAewFLALAVLNSAM-NPLIYTLTSNEMRRA 302
Cdd:cd15336  231 ILLFVLSWSPYACVALIAWAGYAHLLTPYMKS--VPAVIAKASAIyNPIIYAITHPKYREA 289
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
29-302 1.43e-12

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 67.19  E-value: 1.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTAnillsgANTYKLTPTQWFFreGSMFVAL- 107
Cdd:cd15316    5 IVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMP------FSTVRSVESCWYF--GESFCTFh 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 --------AASVFSLLAIAIERHLTMLKMKLHNNGKTCRVF-MLISTVWFIAAILGGLP-------------VMGWNCID 165
Cdd:cd15316   77 tccdvsfcYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSgICISVSWIFSLTYSFSVfytgvnddgleelVNALNCVG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 166 SinnCSTVLplyHKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSE----KSMALLKTVII 241
Cdd:cd15316  157 G---CQIIL---NQNWVLVDFLLFFIPTFAMIILYGKIFLVAKQQARKIEMTSSKAESSSESYKDrvarRERKAAKTLGI 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982742395 242 VLSCFIACWAPLFILLLLDVACQTLTCSILYK-AEWFlalAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15316  231 TVIAFLVSWLPYLIDVLIDAFMNFITPPYIYEiCCWC---AYYNSAMNPLIYALFYPWFRKA 289
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
38-303 1.69e-12

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 66.60  E-value: 1.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  38 IILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILlsgantYKLTPTQWFFRE--GSMFVAL-----AAS 110
Cdd:cd15309   14 IVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVV------YLEVVGEWRFSRihCDIFVTLdvmmcTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 111 VFSLLAIAIERHLTMLKMKLHNNGKTC--RVFMLISTVWFIAAILGGLPVMGWNcidsiNNCSTVLPLYHKAYILFCTTV 188
Cdd:cd15309   88 ILNLCAISIDRYTAVAMPMLYNTRYSSkrRVTVMISVVWVLSFAISCPLLFGLN-----NTDQNECIIANPAFVVYSSIV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 189 -FSVILMAIVILYARIYALVrtrsrklvfrkvangrgsnkssEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQTLT 267
Cdd:cd15309  163 sFYVPFIVTLLVYVQIYIVL----------------------QKEKKATQMLAIVLGVFIICWLPFFITHILNMHCDCNI 220
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 982742395 268 CSILYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15309  221 PPALYSA--FTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
39-303 1.87e-12

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 66.53  E-value: 1.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV----YTANILLSGANTYKLTPTQWFFREgsmFVALAASVFSL 114
Cdd:cd17790   15 VTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFsmnlYTTYILMGHWALGTVACDLWLALD---YVASNASVMNL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 115 LAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVMGWNCI---DSINNCSTVLPLYHKAYILFCTTV-- 188
Cdd:cd17790   92 LIISFDRYFSITRPLTYRAKRTPrRAAIMIGLAWLISFVLWAPAILFWQYLvgeRTVLAGQCYIQFLSQPIITFGTAIaa 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 189 FSVILMAIVILYARIYalvrtrsRKLVfrkvangrgsnksSEKSMAllKTVIIVLSCFIACWAPLFILLLLDVACQTLTC 268
Cdd:cd17790  172 FYLPVTIMIILYWRIY-------RETI-------------KEKKAA--RTLSAILLAFILTWTPYNIMVLVSTFCKDCVP 229
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 982742395 269 SILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd17790  230 KTLWELGYWLCY--VNSTVNPMCYALCNKSFRDTF 262
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
30-303 2.25e-12

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 66.58  E-value: 2.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFI-IVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLlagvVYTANI---LLSGANTYKLtptqWFF-REGSMF 104
Cdd:cd15337    5 IYIaIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDF----GFSAVNgfpLKTISSFNKK----WIWgKVACEL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALAASVF------SLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGW----------NC-IDS 166
Cdd:cd15337   77 YGFAGGIFgfmsitTLAAISIDRYLVIAKpLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWgryvpegfqtSCtFDY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 167 INNCSTVLPLYHKAYIL-FCTTVFsvilmAIVILYARIYALVRTRSRKLVF---RKVANGRGSNKSSEKS-MALLKTVII 241
Cdd:cd15337  157 LSRDLNNRLFILGLFIFgFLCPLL-----IIIFCYVNIIRAVRNHEKEMTQtakSGMGKDTEKNDARKKAeIRIAKVAII 231
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 242 VLSCFIACWAPLFILLLLdvacqtltcSILYKAEW---FLA-LAVL---NSAM-NPLIYTLTSNEMRRAF 303
Cdd:cd15337  232 LISLFLLSWTPYAVVALL---------GQFGPAYWitpYVSeLPVMfakASAIyNPIIYALSHPKFRAAL 292
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
28-303 2.64e-12

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 66.34  E-value: 2.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLL--------AGVVYTANILLSGANTYKLTptQWFFr 99
Cdd:cd14971    4 PLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTfllfcvpfTATIYPLPGWVFGDFMCKFV--HYFQ- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 100 egsmFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINN-----CSTVL 174
Cdd:cd14971   81 ----QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPgnrtvCSEAW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLY-HKAYILFCTTVFSVILMAIVIlyARIYALVRTRsrklVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPL 253
Cdd:cd14971  157 PSRaHRRAFALCTFLFGYLLPLLLI--CVCYAAMLRH----LWRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPI 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982742395 254 FILLLL-DVACQTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14971  231 HAILLLvALGPFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
39-303 3.89e-12

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 65.89  E-value: 3.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV-----YTANILLSGANTYKLTPTQWFFREgsmfVALAASVFS 113
Cdd:cd15393   15 VVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFsipfqFQAALLQRWVLPRFMCPFCPFVQV----LSVNVSVFT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 114 LLAIAIERHLTMLKMKLHNNGKtCRVFMLISTVWfIAAILGGLPVM----GWNCIDSINN-----CSTVLPL--YHKAY- 181
Cdd:cd15393   91 LTVIAVDRYRAVIHPLKARCSK-KSAKIIILIIW-ILALLVALPVAlalrVEELTDKTNNgvkpfCLPVGPSddWWKIYn 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 -ILFCTTVFsVILMAIVILYARIYALVRTrSRKLVFRKVANGRGSNKSSEKsmaLLKTVIIVLSCFIACWAPLFILLLLD 260
Cdd:cd15393  169 lYLVCVQYF-VPLVIICYAYTRIAVKIWG-TKAPGNAQDVRDDEILKNKKK---VIKMLIIVVALFALCWLPLQTYNLLN 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 982742395 261 VACQTLTCSILYKAEWFLA--LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15393  244 EIKPEINKYKYINIIWFCShwLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
29-301 5.03e-12

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 65.75  E-value: 5.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG------VVYTANillsgANTYKLTPTQWFFREGS 102
Cdd:cd14982    5 IVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVltlpfrIYYYLN-----GGWWPFGDFLCRLTGLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 MFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTV--------L 174
Cdd:cd14982   80 FYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTcfeflsewL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAYILFCTTVFSVILMAIVILYARIyalVRTRSRKLVfrkvangrGSNKSSEKSMAlLKTVIIVLSCFIACWAP-- 252
Cdd:cd14982  160 ASAAPIVLIALVVGFLIPLLIILVCYSLI---IRALRRRSK--------QSQKSVRKRKA-LRMILIVLAVFLVCFLPyh 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 253 ----LFILLLLDVACQTLTCSILYKAEWF-LALAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd14982  228 vtriLYLLVRLSFIADCSARNSLYKAYRItLCLASLNSCLDPLIYYFLSKTFRK 281
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
30-303 5.74e-12

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 65.24  E-value: 5.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCcfIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV----VYTANILLSGANTYKLTPTQWFFREGSMFV 105
Cdd:cd15308    8 VLLILA--IIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALlvlpLYVYSEFQGGVWTLSPVLCDALMTMDVMLC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 alAASVFSLLAIAIERHLTM-LKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNciDSINNCSTVLPLYHKAYILF 184
Cdd:cd15308   86 --TASIFNLCAISVDRFIAVsVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLN--NVPNRDPAVCKLEDNNYVVY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 CT--TVFSVILMAIVILYARIYALVRTRsrklvfrkvangrgsnksseKSMALLKtviIVLSCFIACWAPLFILLLLDVA 262
Cdd:cd15308  162 SSvcSFFIPCPVMLVLYCAMFRGLGRER--------------------KAMRVLP---VVVGAFLFCWTPFFVVHITRAL 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 982742395 263 CQTLTC--SILYKAEWflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15308  219 CESCSIppQLISIVTW---LGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
29-303 9.25e-12

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 64.59  E-value: 9.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFiiLENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvyTANILLSGANTYKLTPTQWFFREGSMFVALA 108
Cdd:cd15328    7 LAMLVVATF--LWNLLVLVTILRVRTFHRVPHNLVASMAVSDVL-----VAALVMPLSLVHELSGRRWQLGRSLCQVWIS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 -------ASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVM-GWNCIDSINNCSTVLPlYHK 179
Cdd:cd15328   80 fdvlcctASIWNVTAIALDRYWSITRhLEYTLRTRRRISNVMIALTWALSAVISLAPLLfGWGETYSEDSEECQVS-QEP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 AYILFCTT-VFSVILMAIVILYARIYalvrtrsrklvfrKVANgrgsnksSEKSMALLktVIIVLSCFIACWAPLFILLL 258
Cdd:cd15328  159 SYTVFSTFgAFYLPLCVVLFVYWKIY-------------KAAQ-------KEKRAALM--VGILIGVFVLCWIPFFLTEL 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 982742395 259 LDVACqtlTCSI--LYKAeWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15328  217 ISPLC---SCDIppIWKS-IFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
29-303 9.31e-12

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 64.88  E-value: 9.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCfIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVY----TANILLsgaNTYKLTPTQWFFREGSMF 104
Cdd:cd15957    6 VMSLIVLA-IVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVvpfgAAHILL---KTWTFGNFWCEFWTSIDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPV-MGW------NCIDSINNCSTVLPL 176
Cdd:cd15957   82 LCVTASIETLCVIAVDRYFAITSpFKYQSLLTKNKARVIILMVWIVSGLTSFLPIqMHWyrathqEAINCYAEETCCDFF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 YHKAYILFCTTV-FSVILMAIVILYARIYALVRTRSRKL------------VFRKVANGRGSNKSSE---KSMALLKTVI 240
Cdd:cd15957  162 TNQAYAIASSIVsFYVPLVIMVFVYSRVFQEAKRQLQKIdksegrfhnqniDQNGSGGGGGNRRRSKfclKEHKALKTLG 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982742395 241 IVLSCFIACWAPLFILLLLDVACQTLTCSILYK-AEWflaLAVLNSAMNPLIYTlTSNEMRRAF 303
Cdd:cd15957  242 IIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYIlLNW---IGYVNSGFNPLIYC-RSPDFRIAF 301
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-292 1.15e-11

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 64.60  E-value: 1.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIileNVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILlsgaNTYKLTPTQW-----------F 97
Cdd:cd15204    8 VLIMLVCGVG---NLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEM----DYYVVRQRSWthgdvlcavvnY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  98 FREGSMFValaaSVFSLLAIAIERHLTMlkMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINN-----CST 172
Cdd:cd15204   81 LRTVSLYV----STNALLVIAIDRYLVI--VHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYANqgkifCGQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 173 VLP----LYHKAYILFCTT---VFSVILMAIVilYARIyalvrtrSRKLVFRKV-----ANGRGSNKSSEKSMALLktvI 240
Cdd:cd15204  155 IWPvdqqAYYKAYYLFLFVlefVLPVLIMTLC--YLRI-------VRKVWFRRVpgqqtEQIRRRLRRRRRKVRLL---V 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 982742395 241 IVLSCFIACWAP---------LFILLLLDVAcqtLTCSILYKAEwflALAVLNSAMNPLIY 292
Cdd:cd15204  223 VILTAFVLCWAPyygyaivrdFFPTLLSKEK---LNTTIFYIVE---ALAMSNSMINTVVY 277
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
29-303 1.35e-11

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 64.32  E-value: 1.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLlagvVYTANILLSGANTYKLT--PTQWFFREGS---M 103
Cdd:cd14985    5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADL----VFVLTLPLWATYTANQYdwPFGAFLCKVSsyvI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLI-STVWFIAAILgGLPVMGWNCI-----DSINNCSTVLPL- 176
Cdd:cd14985   81 SVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTcALIWVVACLL-SLPTFLLRSLqaienLNKTACIMLYPHe 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 -YHKAYILFCTTV-FSVILMAIVILYARIYALVRTRSRKlvfrkvangrgSNKSSEKSMALLKTVIIVLSCFIACWAPLF 254
Cdd:cd14985  160 aWHFGLSLELNILgFVLPLLIILTCYFHIARSLRKRYER-----------TGKNGRKRRKSLKIIFALVVAFLVCWLPFH 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 255 ILLLLDVACQT---LTCSILYKAEWFLALAVL----NSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14985  229 FFKFLDFLAQLgaiRPCFWELFLDLGLPIATClaftNSCLNPFIYVFVDRRFRQKV 284
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
29-303 1.99e-11

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 63.86  E-value: 1.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVL-LTIWRTKKFHKPMYYFigNLALSDLLAGV---VYTANILLSGANTY-----KLTPtqwFFR 99
Cdd:cd14974    5 VLYALIFLLGLPGNGLVIwVAGFKMKRTVNTVWFL--NLALADFLFCLflpFLIVYIAMGHHWPFgsvlcKLNS---FVI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 100 EGSMFvalaASVFSLLAIAIER-HLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGgLPVMGW-------NCIDSINNCS 171
Cdd:cd14974   80 SLNMF----ASVFLLTAISLDRcLLVLHPVWAQNHRTVRLASVVCVGIWILALVLS-VPYFVFrdtvthhNGRSCNLTCV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVLPLY---HKAYILFCTTV-FSVILMAIVILYARIyaLVRTRSRKLvfrkvangRGSNKSseksmalLKTVIIVLSCFI 247
Cdd:cd14974  155 EDYDLRrsrHKALTVIRFLCgFLLPLLIIAICYSVI--AVKLRRKRL--------AKSSKP-------LRVLLAVVVAFF 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 982742395 248 ACWAPLFILLLLDVACQTLTCSILYKAEWF-LALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14974  218 LCWLPYHVFALLELVAAAGLPEVVLLGLPLaTGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
28-303 2.72e-11

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 63.43  E-value: 2.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVccfiILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLA-------GVVYTANILLSGANTYKLTPTQWFFre 100
Cdd:cd15091    8 SVVFVVG----LVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVtttmpfqSTVYLMNSWPFGDVLCKIVISIDYY-- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 gSMFvalaASVFSLLAIAIERHL------------TMLKMKLHNngkTCrVFMLISTVWFIAAILGGLPVmgwNCIDSIN 168
Cdd:cd15091   82 -NMF----TSIFTLTMMSVDRYIavchpvkaldfrTPLKAKIIN---IC-IWLLSSSVGISAIVLGGTKV---REDVDST 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 169 NCSTVLP----LYHKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKLVfrkvangRGSNKSSEKSMALLKTVIIVLS 244
Cdd:cd15091  150 ECSLQFPdddySWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLL-------SGSREKDRNLRRITRLVLVVVA 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 245 CFIACWAPLFILLLLDVACQTLTCSILYKAEWF-LALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15091  223 VFVVCWTPIHIFILVEALGSVSHSTAAVSSYYFcIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
28-303 3.09e-11

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 63.29  E-value: 3.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYkltptqWFFREG------ 101
Cdd:cd15202    4 IVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNT------WIFGLFmchfsn 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 -SMFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFmLISTVWFIA-------AILGGL--PVMGWNCIDSInnCS 171
Cdd:cd15202   78 fAQYCSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKF-IIAVIWTLAlafalphAICSKLetFKYSEDIVRSL--CL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVLP----LYHKAYILfCTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMalLKTVIIVLSCFI 247
Cdd:cd15202  155 EDWPeradLFWKYYDL-ALFILQYFLPLLVISFAYARVGIKLWASNMPGDATTERYFALRRKKKKV--IKMLMVVVVLFA 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 248 ACWAPLFILLLL---DVACQTLTCSILYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15202  232 LCWLPFNIYVLLlssKPDYLIKTINAVYFA--FHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
28-309 3.12e-11

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 63.39  E-value: 3.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTY------KLTPTqWFFREg 101
Cdd:cd15305    4 ALLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYawplprYLCPI-WISLD- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 smFVALAASVFSLLAIAIERHLTMLKMKLHN--NGKTcRVFMLISTVWFIA-AILGGLPVMGWNcIDSINNCSTVLPLYH 178
Cdd:cd15305   82 --VLFSTASIMHLCAISLDRYVAIRNPIEHSrfNSRT-KAMMKIAAVWTISiGISMPIPVIGLQ-DDEKVFVNGTCVLND 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 KAYILFCTTV-FSVILMAIVILYA-RIYALVRTRSrklvfrkVANGRGSNksseksmallKTVIIVLSCFIACWAPLFIL 256
Cdd:cd15305  158 ENFVLIGSFVaFFIPLIIMVITYClTIQVLQRQQA-------INNERRAS----------KVLGIVFFLFLIMWCPFFIT 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 982742395 257 LLLDVAC-----QTLTCSILykaEWFLALAVLNSAMNPLIYTLTSNEMRRAFIKMLNC 309
Cdd:cd15305  221 NILSVLCkeacdQKLMEELL---NVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
28-303 4.03e-11

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 63.05  E-value: 4.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAgvvyTANILLSGAntyKLTPTQWFFREGSMFVAL 107
Cdd:cd15089    4 TALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALA----TSTLPFQSA---KYLMETWPFGELLCKAVL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 A-------ASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLIST-VWFIAAILgGLPVMGWNCIDSINNCSTVL----- 174
Cdd:cd15089   77 SidyynmfTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINIcIWVLSSGV-GVPIMVMAVTKTPRDGAVVCmlqfp 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 --PLYHKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKLVFrkvangrGSNKSSEKSMALLKTVIIVLSCFIACWAP 252
Cdd:cd15089  156 spSWYWDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLS-------GSKEKDRNLRRITRMVLVVVAAFIICWTP 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982742395 253 LFILLLLDVACQTLTCSILYKAEWFL--ALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15089  229 IHIFVIVWTLVDIDRRNPLVVAALHLciALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
42-309 4.58e-11

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 62.54  E-value: 4.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  42 NVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG--VVYTANILLSGANTYKLtPTQ----WFFREgsmFVALAASVFSLL 115
Cdd:cd15306   18 NILVILAVSLEKKLQYATNYFLMSLAVADLLVGlfVMPIALLTILFEAMWPL-PLVlcpiWLFLD---VLFSTASIMHLC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 116 AIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIAA-ILGGLPVMGW-NCIDSINNCSTVL-PLYHKAYILFCTTVFSV 191
Cdd:cd15306   94 AISLDRYIAIKKPIQASQYNSrATAFIKITVVWLISIgIAIPVPIKGIeTDVDNPNNITCVLtKERFGDFILFGSLAAFF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 192 ILMAIVILyarIYALVRTRSRKlvfRKVANGRGSNksseksmallKTVIIVLSCFIACWAPLFILLLLDVACQTLTCSIL 271
Cdd:cd15306  174 TPLAIMIV---TYFLTIHALRK---QTITNEQRAS----------KVLGIVFFLFLLMWCPFFITNITSVLCDSCNQTTL 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 982742395 272 YK-AEWFLALAVLNSAMNPLIYTLTSNEMRRAFIKMLNC 309
Cdd:cd15306  238 QMlMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
39-303 4.84e-11

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 62.53  E-value: 4.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV-------VYTAnillsgANTYKLTPTQWFFREGSMFVALAASV 111
Cdd:cd15301   15 VGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVismplftVYTA------LGYWPLGYEVCDTWLAIDYLASNASV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 112 FSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDS-----INNCsTVLPLYHKAYILFC 185
Cdd:cd15301   89 LNLLIISFDRYFSVTRpLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWPYIEGkrtvpAGTC-YIQFLETNPYVTFG 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 186 TTV--FSVILMAIVILYARIYALVRTRSRKlvfrkvangrgsnksSEKSMAllKTVIIVLSCFIACWAPLFILLLLDVAC 263
Cdd:cd15301  168 TALaaFYVPVTIMCILYWRIWRETKKRQKK---------------QESKAA--KTLSAILLAFIVTWTPYNVLVLIKAFF 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 982742395 264 QTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15301  231 PCSDTIPTELWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
29-302 5.06e-11

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 62.71  E-value: 5.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVC-CFII--LENVLVLLTIWRTKKfHKP--MYYFIGNLALSDLLagvvyTANILLSGANTYKLTpTQW------- 96
Cdd:cd15382    2 VSIIVYSvLFLIaaVGNLTVLLILLRNRR-RKRsrVNILLMHLAIADLL-----VTFIMMPLEIGWAAT-VAWlagdflc 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  97 ----FFRegsMFvALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRvFMLIsTVWFIAAILGgLP------VMGWNCID 165
Cdd:cd15382   75 rlmlFFR---AF-GLYLSSFVLVCISLDRYFAILKpLRLSDARRRGR-IMLA-VAWVISFLCS-IPqsfifhVESHPCVT 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 166 SINNCST--VLP--LYHKAYILFC-TTVFSVILMAIVILYARIYALVRTRSR--KLVFRKVANGRGSNKSSEKSMA---- 234
Cdd:cd15382  148 WFSQCVTfnFFPshDHELAYNIFNmITMYALPLIIIVFCYSLILCEISRKSKekKEDVSEKSSSVRLRRSSVGLLErars 227
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982742395 235 -LLKTVIIVLSCFIACWAPLFILLL---LDVACQTLTCSILYKAEWflALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15382  228 rTLKMTIVIVLVFIICWTPYFIMSLwywFDRESASKVDPRIQKGLF--LFAVSNSCMNPIVYGYFSIDLRRE 297
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
29-303 5.81e-11

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 62.49  E-value: 5.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFI----ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGantyklTPTQW----FFRE 100
Cdd:cd15205    1 TAFVITYVLIfvlaLFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQN------ISSNWlggaFMCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 GSMFV---ALAASVFSLLAIAIERHLTM---LKMKLHNNGKtcRVFMLISTVWFIAAILGGlPVMGWNCIDSINNCSTVL 174
Cdd:cd15205   75 MVPFVqstAVVTSILTMTCIAVERHQGIvhpLKMKWQYTNR--RAFTMLGLVWIVSVIVGS-PMLFVQQLEVKYDFLYEK 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 -----------PLYHKAYILFCTTV-FSVILMAIVILYARI-YAL-VRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVI 240
Cdd:cd15205  152 rhvcclerwysPTQQKIYTTFILVIlFLLPLTTMLFLYSRIgYELwIKKRVGDASVLQTIHGIEMSKISRKKKRAVKMMV 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 241 IVLSCFIACWAPLFILLL------LDVACQTLTCSILYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15205  232 TVVLLFAVCWAPFHVVHMmieysnLENKYDGVTIKLIFAI--VQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
30-303 6.70e-11

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 62.32  E-value: 6.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAgvvyTANILLSGANTYKLTptqWFFREGSMFVALA- 108
Cdd:cd15090    6 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA----TSTLPFQSVNYLMGT---WPFGNILCKIVISi 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ------ASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSIN---NCSTVLP---L 176
Cdd:cd15090   79 dyynmfTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQgsiDCTLTFShpsW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 YHKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKLVFrkvangrGSNKSSEKSMALLKTVIIVLSCFIACWAPLFIL 256
Cdd:cd15090  159 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLS-------GSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIY 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 982742395 257 LLLDvACQTLTCSILYKAEWF--LALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15090  232 VIIK-ALVTIPETTFQTVSWHfcIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
28-303 7.12e-11

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 61.97  E-value: 7.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV----VYTANILLSGANTYKLTPTQWFFREgsm 103
Cdd:cd15300    4 AAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIfsmnLYTSYILMGYWALGSLACDLWLALD--- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVALAASVFSLLAIAIERHLTMLKMKLHNNGKTC-RVFMLISTVWFIAAILGGLPVMGWNCI---DSINNCSTVLPLYHK 179
Cdd:cd15300   81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPkRAGIMIGLAWLISFILWAPPILCWQYFvgkRTVPERECQIQFLSE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 AYILFCTTV--FSVILMAIVILYARIYalvrtrsrklvfrkvangrgsnKSSEKSMALLKTVIIVLSCFIACWAPLFILL 257
Cdd:cd15300  161 PTITFGTAIaaFYIPVSVMTILYCRIY----------------------KETIKERKAAQTLSAILLAFIITWTPYNIMV 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 982742395 258 LLDVACQTLTCSILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15300  219 LVSTFCSDCIPLTLWHLGYWLCY--VNSTVNPMCYALCNKTFRKTF 262
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
28-303 8.41e-11

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 62.12  E-value: 8.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvytanILLSGANTYKLTPTQWFFREGSMFVAL 107
Cdd:cd15082   17 AALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFL--------VSLTGGTISFLTNARGYFFLGVWACVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AA---------SVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLP--- 175
Cdd:cd15082   89 EGfavtffgivALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPnwy 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 176 ---LYHKAYIL-FCTTVFSVILMAIVILYARIYalvrtrsRKLvfRKVANGRGSNKSSEK-SMALLKTVIIVLSCFIACW 250
Cdd:cd15082  169 sgnMHDHTYIItFFTTCFILPLGVIFVSYGKLL-------QKL--RKVSNTQGRLGNARKpERQVTRMVVVMIVAFMVCW 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 251 APLFILLLLDVACQTLTCSILYKA--EWFLALAvlnSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15082  240 TPYAAFSILVTAHPTIHLDPRLAAipAFFSKTA---AVYNPIIYVFMNKQFRKCL 291
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
39-303 9.56e-11

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 61.52  E-value: 9.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV----VYTANILLSGANTYKLTPTQWFFREgsmFVALAASVFSL 114
Cdd:cd15297   15 IIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVfsmnLYTLYTVIGYWPLGPVVCDLWLALD---YVVSNASVMNL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 115 LAIAIERHLTMLKMKLHNNGKTCRVF-MLISTVWFIAAILGGLPVMGWNCI---DSINNCSTVLPLYHKAYILFCTTV-- 188
Cdd:cd15297   92 LIISFDRYFCVTKPLTYPVKRTTKMAgMMIAAAWVLSFILWAPAILFWQFIvggRTVPEGECYIQFFSNAAVTFGTAIaa 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 189 FSVILMAIVILYARIyalvrtrsrklvfrkvangrgsNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQTLTC 268
Cdd:cd15297  172 FYLPVIIMTVLYWQI----------------------SRASSREKKVTRTILAILLAFIITWTPYNVMVLINTFCASCIP 229
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 982742395 269 SILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15297  230 NTVWTIGYWLCY--INSTINPACYALCNATFKKTF 262
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
28-303 1.24e-10

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 61.46  E-value: 1.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV-YTANILLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd15401    4 AGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYpYPLILLAIFHNGWTLGNIHCQISGFLMGLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHL----TMLKMKLHNNGKTCrVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYI 182
Cdd:cd15401   84 VIGSVFNITAIAINRYCyichSLRYDKLYNMKKTC-CYVCLTWVLTLAAIVPNFFVGSLQYDPRIYSCTFAQTVSSSYTI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 183 LFCTTVFSVILMAIVILYARIYAL---VRTRSRKLVFRKVANGRGSNksseksmalLKTVIIVLSCFIACWAPL-FILLL 258
Cdd:cd15401  163 TVVVVHFIVPLSIVTFCYLRIWVLviqVKHRVRQDSKQKLKANDIRN---------FLTMFVVFVLFAVCWGPLnFIGLA 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 982742395 259 LDVACQTLTCSIlykAEWFLAL----AVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15401  234 VAINPLKVAPKI---PEWLFVLsyfmAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
29-303 1.76e-10

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 60.86  E-value: 1.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytANILLSGANTYkLTPTQWFFREGS------ 102
Cdd:cd14995    5 FLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLV---AAGLPNEIESL-LGPDSWIYGYAGcllity 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 -MFVALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAI-------LGGLPVMGWNCIDSINNCSTV 173
Cdd:cd14995   81 lQYLGINASSLSITAFTIERYIAICHpMKAQFICTVSRAKKIICFVWIFTSLycspwlfLLDLSIKHYGDDIVVRCGYKV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 174 LPLYHKAYILFCTTVFSVI-LMAIVILYARIyALVRTRSRKLVfrkvangrgsnksseksmalLKTVIIVLSCFIACWAP 252
Cdd:cd14995  161 SRHYYLPIYLADFVLFYVIpLLLAIVLYGLI-GRILFSSRKQV--------------------TKMLAVVVVLFALLWMP 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 253 LFILLLLDVacqtlTCSILYKAEWFLALA----VLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14995  220 YRTLVVYNS-----FASPPYLDLWFLLFCrtciYLNSAINPILYNLMSQKFRAAF 269
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
28-303 2.09e-10

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 60.57  E-value: 2.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV----VYTANILLSGANTYKLTPTQWFFREgsm 103
Cdd:cd15296    4 AVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGfcipLYIPYVLTGRWKFGRGLCKLWLVVD--- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVALAASVFSLLAIAIERHLTMLKMKLH--NNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSinncSTVLP------ 175
Cdd:cd15296   81 YLLCTASVFNIVLISYDRFLSVTRAVSYraQKGMTRQAVLKMVLVWVLAFLLYGPAIISWEYIAG----GSIIPegecya 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 176 -LYHKAYILFCTTVFSVILMAIVILY--ARIYALVRTRSRKLvfrkvangrgsnkSSEKSMAllKTVIIVLSCFIACWAP 252
Cdd:cd15296  157 eFFYNWYFLMTASTLEFFTPFISVTYfnLSIYLNIQKRRFRL-------------SRDKKVA--KSLAIIVCVFGLCWAP 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982742395 253 LFILLLLDVACQTlTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15296  222 YTLLMIIRAACHG-HCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
28-299 2.64e-10

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 60.56  E-value: 2.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVccfiILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL-------LAGVVYTANILLSGANTykLTPTQWFFRE 100
Cdd:cd15388    8 AIIFACA----LLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLvvaffqvLPQLVWDITDRFRGPDV--LCRLVKYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 GSMFvalaASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGgLPVM----GWNCIDSINNC--STVL 174
Cdd:cd15388   82 VGMF----ASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVAWAISLILS-LPQVfifsKVEVAPGVYECwaCFIE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAYILFCTTVFSVILMAIVI---------LYARIYALVRTRSRKLVFRKVANGRGSNKSsEKSMALLKTV----II 241
Cdd:cd15388  157 PWGLKAYVTWITLVVFVLPTLIITvcqvlifkeIHINIYLKSQIIVAVVKKKQLLSSRASSVA-EVSKAMIKTVkmtlVI 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982742395 242 VLScFIACWAPLFILLLLDV-----ACQTLTCSILykaewfLALAVLNSAMNPLIYTLTSNEM 299
Cdd:cd15388  236 VLV-YVLCWAPFFLVQLWSVwdpkaPTEGATFTIL------MLLASLNSCTNPWIYMAFSSSV 291
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
32-301 2.74e-10

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 60.56  E-value: 2.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLlagvvytanILLSGANTYKLTPTQ---WFFRE-------G 101
Cdd:cd15189    8 FSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADL---------VFVSGLPFWAMNILNqfnWPFGEllcrvvnG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSI---NNCSTVLPLYH 178
Cdd:cd15189   79 VIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIpdlNITACVLLYPH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 KAYILFCTTVFSVI---LMAIVILYARIYALVRTRSRKLVFRKvangRGSNKSseKSMALlktVIIVLSCFIACWAPLFI 255
Cdd:cd15189  159 EAWHFAHIVLLNIVgflLPLLVITFCNYNILQALRTREESTRC----EDRNDS--KATAL---VLAVTLLFLVCWGPYHF 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 256 LLLLDVACQTltcSILYKAEWFLAL----------AVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15189  230 FTFLDFLFDV---GVLDECFWEHFIdiglqlavflAFSNSCLNPVLYVFVGRYFRR 282
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
29-303 2.86e-10

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 60.45  E-value: 2.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV-----YTANILLS----GAntyKLTPTQWFFR 99
Cdd:cd15392    5 LMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFcvpfsFIALLILQywpfGE---FMCPVVNYLQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 100 EGSMFValaaSVFSLLAIAIERHLTM---LKMKLHNNgktcRVFMLISTVWFIAAILgGLP-------VMGWNCIDSINN 169
Cdd:cd15392   82 AVSVFV----SAFTLVAISIDRYVAImwpLRPRMTKR----QALLLIAVIWIFALAT-ALPiaitsrlFEDSNASCGQYI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 170 CSTVLPLYHKAYIlfcttvFSVILMA---------IVILYARIYALVRTRSrklvfrkvANGRGSNKS----SEKSMALL 236
Cdd:cd15392  153 CTESWPSDTNRYI------YSLVLMIlqyfvplavLVFTYTRIGIVVWAKR--------TPGEAENNRdqrmAESKRKLV 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 237 KTVIIVLSCFIACWAPLFILLLLDVACQTLTCSILYKAEWFLA--LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15392  219 KMMITVVAIFALCWLPLNILNLVGDHDESIYSWPYIPYLWLAAhwLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
30-300 3.22e-10

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 60.37  E-value: 3.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFI-ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV-YTANILLSGANtykltptQWFFRE-GSMFVA 106
Cdd:cd15074    5 IYLTVIGILsTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFgYPLAIISAFAH-------RWLFGDiGCVFYG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFS------LLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWN----------CidSINNC 170
Cdd:cd15074   78 FCGFLFGccsintLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGsygpepfgtsC--SIDWT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 171 STVLPLYHKAYILFCTT-VFSVILMAIVILYARIYALVRtRSRKLVFRKVANGRGSNKSSEKsmaLLKTVIIVLSCFIAC 249
Cdd:cd15074  156 GASASVGGMSYIISIFIfCYLLPVLIIVFSYVKIIRKVK-SSRKRVAGFDSRSKRQHKIERK---VTKVAVLICAGFLIA 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 250 WAPLFILLLLDVACQTLTCSILykaewFLALAVL----NSAMNPLIYTLTSNEMR 300
Cdd:cd15074  232 WTPYAVVSMWSAFGSPDSVPIL-----ASILPALfaksSCMYNPIIYLLFSSKFR 281
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
29-303 3.34e-10

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 60.20  E-value: 3.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSD--LLAGVVYtanilLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd15972    5 LVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADelFMLGLPF-----LAAQNALSYWPFGSFMCRLVMTVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LA---ASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLIS-TVWFIAAILgGLPVMGWNCID-SINNCSTVLP----LY 177
Cdd:cd15972   80 AInqfTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNaTVWALSFLV-VLPVVIFSGVPgGMGTCHIAWPepaqVW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAYILFCTTV-FSVILMAIVILYARIYALVRTRSRKLvfRKVANGRgsnKSSEKSMAllKTVIIVLSCFIACWAPLFIL 256
Cdd:cd15972  159 RAGFIIYTATLgFFCPLLVICLCYLLIVVKVRSSGRRV--RATSTKR---RGSERKVT--RMVVIVVAAFVLCWLPFYAL 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 982742395 257 LLLDVACQTLTCSILYKAEWF-LALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15972  232 NIVNLVCPLPEEPSLFGLYFFvVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-296 8.87e-10

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 58.99  E-value: 8.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvytanILLSG---ANTYKLtpTQWFFRE---- 100
Cdd:cd14999    3 GTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLL--------YLLTIpfyVSTYFL--KKWYFGDvgcr 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 ---GSMFVALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVfMLISTVWFIAAILgGLPVMGWNCIDSINNCS----- 171
Cdd:cd14999   73 llfSLDFLTMHASIFTLTVMSTERYLAVVKpLDTVKRSKSYRK-LLAGVIWLLSLLL-TLPMAIMIRLVTVEDKSggskr 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 ----TVLPLYHKAYIlfcTTVFSVILMA----IVILYARiyaLVRTrsrklVFRKVANGRGSNKSSEKSMALLKTVIIVL 243
Cdd:cd14999  151 iclpTWSEESYKVYL---TLLFSTSIVIpglvIGYLYIR---LARK-----YWLSQAAASNSSRKRLPKQKVLKMIFTIV 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 244 SCFIACWAPLFILLLLDVACQTLTCS---ILYKAEWFLALAVLNSAMNPLIYTLTS 296
Cdd:cd14999  220 LVFWACFLPFWIWQLLYLYSPSLSLSprtTTYVNYLLTCLTYSNSCINPFLYTLLT 275
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
32-303 1.01e-09

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 59.25  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCCFI-------ILENVLVLLTIWRTKKFH-KPMYYFIGNLALSDLLAGVV---YTANILLSGANTYKLTPTQWFFRE 100
Cdd:cd15320    2 VLTGCFLsvlilstLLGNTLVCAAVIRFRHLRsKVTNFFVISLAVSDLLVAVLvmpWKAVAEIAGFWPFGSFCNIWVAFD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 gsmFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRV-FMLISTVWFIAAILGGLPV-MGWNCID------------- 165
Cdd:cd15320   82 ---IMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVaFIMISVAWTLSVLISFIPVqLNWHKAKptsfldlnaslrd 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 166 -SINNCSTVLplyHKAYILFCTTVFSVILMAIVIL-YARIYALVRTRSRKL-------VFRKVANGRGSNKSS------- 229
Cdd:cd15320  159 lTMDNCDSSL---NRTYAISSSLISFYIPVAIMIVtYTRIYRIAQKQIRRIsaleraaVHAKNCQNSTGNRGSgdcqqpe 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 230 -------EKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQT----LTCSILYKAEWFLALAVLNSAMNPLIYTLTSnE 298
Cdd:cd15320  236 ssfkmsfKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKPtstePFCISSTTFDVFVWFGWANSSLNPIIYAFNA-D 314

                 ....*
gi 982742395 299 MRRAF 303
Cdd:cd15320  315 FRKAF 319
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
29-303 1.09e-09

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 58.76  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCcfIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLS-GANTYKLTPTQWFFREGSMFVAL 107
Cdd:cd15402    7 LIFTIVV--DILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSiFHNGWNLGYLHCQISGFLMGLSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTM---LKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCS---TVLPLYHKAY 181
Cdd:cd15402   85 IGSIFNITGIAINRYCYIchsLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTfaqSVSSAYTIAV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 ILFCttvFSVILMAIVILYARIYALVRTrsrklVFRKVANGRgSNKSSEKSMALLKTVIIVLSCFIACWAPL-FILLLLD 260
Cdd:cd15402  165 VFFH---FILPIIIVTFCYLRIWILVIQ-----VRRRVKPDN-KPKLKPHDFRNFVTMFVVFVLFAVCWAPLnFIGLAVA 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 982742395 261 VACQTLTCSI---LYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15402  236 VDPETIVPRIpewLFVASYYMAY--FNSCLNAIIYGLLNQNFRREY 279
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
37-261 1.30e-09

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 58.23  E-value: 1.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  37 FIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytanillsganTYKLTPTQWFFRE----GSMFVALA---- 108
Cdd:cd15905   11 LIIFANLFIILGIACNRKLHNTANYFFLSLLLADLLTGV------------ALPFIPGMSNESRrgyhSCLFVYVApnfl 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 --ASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFML-ISTVWFIAAILGGLPVMGWNCIDSINNCST--VLPlyhKAYIL 183
Cdd:cd15905   79 flSFLANLLMVHYERYLCIVYPLQYHNFWVHRWVPLaLLLTWALPLLFACLPALGWNNWTPGSNCSYkqVFP---AAYIY 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 184 F--CTTVFSVILmAIVILYARIYALVRTRSR--KLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLL 259
Cdd:cd15905  156 LevYGLVLPSIL-AIAFMSVRVLAVARRQLQdiCKLLRAVQRDGPSELEQQLNLRYAKCIAGVSLTFLVCWVPYIAYLLM 234

                 ..
gi 982742395 260 DV 261
Cdd:cd15905  235 SV 236
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
29-303 1.60e-09

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 58.06  E-value: 1.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSD---LLAGVVYTANIllsgantYKLtpTQWFFreGS--- 102
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDlafLVCCVPFTAAL-------YAT--PSWVF--GDfmc 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 ------MFVALAASVFSLLAIAIERH-LTMLKMKLHNNgKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINN------ 169
Cdd:cd15095   74 kfvnymMQVTVQATCLTLTALSVDRYyAIVHPIRSLRF-RTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWygpqty 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 170 CSTVLP--LYHKAYILFCTTVFSVI-LMAIVILYARIYalvrtrsRKLVFRKVANGRGSNKSSEKSMA----LLKTVIIV 242
Cdd:cd15095  153 CREVWPskAFQKAYMIYTVLLTYVIpLAIIAVCYGLIL-------RRLWRRSVDGNNQSEQLSERALRqkrkVTRMVIVV 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982742395 243 LSCFIACWAPLFILLL---LDVACQtLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15095  226 VVLFAICWLPNHVLNLwqrFDPNFP-ETYATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
32-302 2.08e-09

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 57.82  E-value: 2.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL---LAGVVYTANILLSGANTYKLTPTQWFFREGsMFVALA 108
Cdd:cd15073    8 IVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLgvsIIGYPFSAASDLHGSWKFGYAGCQWYAFLN-IFFGMA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 aSVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAYILFCTTV 188
Cdd:cd15073   87 -SIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGATCTINWRKNDSSFVSYT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 189 FSVILMAIVILYARIYALVRTRSRKLvfRKVANGRGS---NKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVACQT 265
Cdd:cd15073  166 MSVIVVNFIVPLAVMFYCYYNVSRFV--KKVLASDCLesvNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASFGEP 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 982742395 266 LTCSilykaEWFLALAVL----NSAMNPLIYTLTSNEMRRA 302
Cdd:cd15073  244 KKIP-----PWMAIIPPLfaksSTFYNPCIYVIANKKFRRA 279
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
30-303 3.30e-09

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 57.53  E-value: 3.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIilENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANT-YKLTPTQWFFREGSMFVALA 108
Cdd:cd15981    8 LFIFLLCMV--GNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITgWPFDNAMCKMSGLVQGMSVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVFSLLAIAIERHLTML---KMKLhnngkTCRVFML-ISTVWFIAAILGGLPVMGWNC--------IDSINNcstVLPL 176
Cdd:cd15981   86 ASVFTLVAIAVERFRCIVhpfRQKL-----TLRKAIVtIVIIWVLALIIMCPSAVTLTVtreehhfmVDDYNN---SYPL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 YH--------KAYILFCTTVFSVILMA----IVILYARIyALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLS 244
Cdd:cd15981  158 YScweawpdtEMRKIYTTVLFSHIYLApltlIVIMYARI-AFKLFKSSAPIRGSQGEEEEGRRVSKRKIKVINMLIIVAL 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 245 CFIACWAPLFILLLL-------DVACQTLTCSILYKAEWflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15981  237 FFTLSWLPLWTLMLLtdyghlsEDQLNLVTVYVFPFAHW---LAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
28-303 3.30e-09

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 57.25  E-value: 3.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTY------KLTPTqWFFREg 101
Cdd:cd15304    4 ALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYrwplpsKLCAV-WIYLD- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 smFVALAASVFSLLAIAIERHLTMLKMKLHN--NGKTcRVFMLISTVWFIA-AILGGLPVMGWNCIDSINNCSTVLPLYH 178
Cdd:cd15304   82 --VLFSTASIMHLCAISLDRYIAIRNPIHHSrfNSRT-KAFLKIIAVWTISvGISMPIPVFGLQDDSKVFKEGSCLLADE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 KAYILFCTTVFSVILMAIVILYariyalvrtrsrklvFRKVANGRGSNKSSEKSMALLKtviIVLSCFIACWAPLFILLL 258
Cdd:cd15304  159 NFVLIGSFVAFFIPLTIMVITY---------------FLTIKSLQQSISNEQKASKVLG---IVFFLFVVMWCPFFITNV 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 982742395 259 LDVACQTLTCSILYKA--EWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15304  221 MAVICKESCNEVVIGGllNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-303 3.37e-09

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 57.09  E-value: 3.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLL--AGVVYTAnilLSGANTYkltptqWFFreGSMFV 105
Cdd:cd15093    4 PCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELfmLGLPFLA---ASNALRH------WPF--GSVLC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 ALA---------ASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCI----DSINNCST 172
Cdd:cd15093   73 RLVlsvdginmfTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTrenqDGSSACNM 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 173 VLP----LYHKAYILFCTTV-FSVILMAIVILYARIYALVRTRSRKLvfrkvanGRGSNKSSEKSMALLktVIIVLSCFI 247
Cdd:cd15093  153 QWPepaaAWSAGFIIYTFVLgFLLPLLIICLCYLLIVIKVKSAGLRA-------GWQQRKRSERKVTRM--VVMVVVVFV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 982742395 248 ACWAPLFILLLLDVACQTLTCSILYKAEWF-LALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15093  224 ICWLPFYVLQLVNVFVQLPETPALVGVYHFvVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
39-303 3.87e-09

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 56.89  E-value: 3.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLL--------AGVVYTANILLSGANTYKLTPtqwFFREGSMFValaaS 110
Cdd:cd15927   15 VLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLllltcvpfTSTIYTLDSWPFGEFLCKLSE---FLKDTSIGV----S 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 111 VFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGgLP------VMGWNCIDSINN--CS----TVLPLY 177
Cdd:cd15927   88 VFTLTALSADRYFAIVNpMRKHRSQATRRTLVTAASIWIVSILLA-IPeaifshVVTFTLTDNQTIqiCYpypqELGPNY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAYILFCTTVFSVI-LMAIVILYARIYALVRTRSRKLVFRKvanGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFIL 256
Cdd:cd15927  167 PKIMVLLRFLVYYLIpLLIIGVFYVLMARHLIRSTRNIGSGQ---NQAAQRQIEARKKVAKTVLAFVVLFAVCWLPRHVF 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982742395 257 LLLDVAcqTLTCSILYKAEWFL------ALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15927  244 MLWFHF--APNGLVDYNAFWHVlkivgfCLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
42-303 6.40e-09

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 56.21  E-value: 6.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  42 NVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG-VVYTANILLSGANTykltptqWFFreGSMFVAL---------AASV 111
Cdd:cd15312   18 NLMVIISISHFKQLHSPTNFLILSLAITDFLLGfLVMPYSMVRSVESC-------WYF--GDLFCKIhssldmmlsTTSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 112 FSLLAIAIERHLTM-----LKMKLHNNgkTCRVFMLIStvWFIAAILG------GLPVMGWNCIDSINNCSTVLPLY--- 177
Cdd:cd15312   89 FHLCFIAVDRYYAVcdplhYRTKITTP--VIKVFLVIS--WSVPCLFAfgvvfsEVNLEGIEDYVALVSCTGSCVLIfnk 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAYILFCTTVFSVILMAIVIlYARIYALVRtRSRKLVFRKVANGRGSNK---SSEKSMALLKTVIIVLSCFIACWAPLF 254
Cdd:cd15312  165 LWGVIASLIAFFIPGTVMIGI-YIKIFFVAR-KHAKVINNRPSVTKGDSKnklSKKKERKAAKTLSIVMGVFLLCWLPFF 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 982742395 255 ILLLLDVACQTLTCSILYKAewFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15312  243 VATLIDPFLNFSTPVDLFDA--LVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
33-301 8.28e-09

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 55.98  E-value: 8.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  33 IVCCFIILENVLVLLTIWRTKKFHKPMYYfIGNLALSDLLAGVVYTANI--LLSGAntykltptQWFFreGSMFVALAAS 110
Cdd:cd15339    9 ILCSTGLVGNILVLFTIIRSRKKTVPDIY-VCNLAVADLVHIIVMPFLIhqWARGG--------EWVF--GSPLCTIITS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 111 V-----FSLLAI----AIERHLTMLK----MKLHNNGKTCRVFMListVWfIAAILGGLPVMGWNCI----DSINNCSTV 173
Cdd:cd15339   78 LdtcnqFACSAImtamSLDRYIALVHpfrlTSLRTRSKTIRINLL---VW-AASFILVLPVWVYAKVikfrDGLESCAFN 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 174 L--PLYHKAYILFCT-TVFSVILMAIVILYARIYALVRTRSRKlvfRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACW 250
Cdd:cd15339  154 LtsPDDVLWYTLYQTiTTFFFPLPLILICYILILCYTWEMYRK---NKKAGRYNTSIPRQRVMRLTKMVLVLVGVFLVSA 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982742395 251 APLFILLLLDVACQTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15339  231 APYHVIQLVNLSVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
29-303 9.15e-09

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 55.89  E-value: 9.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHK--PMYYFIGNLALSDL--------LAGVVYTANILLSGANTYKLTPtqwFF 98
Cdd:cd15098    5 VVFGLIFCLGVLGNSLVITVLARVKPGKRrsTTNVFILNLSIADLffllfcvpFQATIYSLPEWVFGAFMCKFVH---YF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  99 REGSMFValaaSVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVM-------GWN------CID 165
Cdd:cd15098   82 FTVSMLV----SIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAvhqdlvhHWTasnqtfCWE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 166 SINNcstvlPLYHKAYILfCTTVFSVILMAIVILYAriYALVRTRSRKlvfrKVANGRGSNKSSEKSMAllKTVIIVLSC 245
Cdd:cd15098  158 NWPE-----KQQKPVYVV-CTFVFGYLLPLLLITFC--YAKVLNHLHK----KLKNMSKKSERSKKKTA--QTVLVVVVV 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 982742395 246 FIACWAPLFILLL---LDVACQTLTCSILYKAEWFLALAvlNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15098  224 FGISWLPHHIIHLwveFGDFPLTQASFVLRITAHCLAYA--NSCVNPIIYAFLSENFRKAY 282
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
29-303 9.86e-09

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 55.64  E-value: 9.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAgvvyTANILLSGANTYKltpTQWFFREGSMFVALA 108
Cdd:cd15092    5 VVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLV----LLTLPFQGTDIFL---GFWPFGNALCKTVIA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 -------ASVFSLLAIAIERHLTM------LKMKLHNNGKTCRVfmlisTVWFIAAILgGLPVMGWNCIDSINN---CST 172
Cdd:cd15092   78 idyynmfTSTFTLTAMSVDRYVAIchpikaLDVRTPHKAKVVNV-----CIWALASVV-GVPVMVMGSAQVEDEeieCLV 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 173 VLPLYHKAY-ILFCTTVFSVILMAIVILYARIYALVRTRsrklvFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWA 251
Cdd:cd15092  152 EIPTPQDYWdPVFGICVFLFSFIIPVLIISVCYSLMIRR-----LRGVRLLSGSKEKDRNLRRITRLVLVVVAVFVGCWT 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 252 PLFILLLLDV----ACQTLTCSILYkaeWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15092  227 PIQIFVLAQGlgvqPSSETAVAILR---FCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
39-300 1.01e-08

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 55.98  E-value: 1.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV-----VYTANILLSGANTYKLTPTQWFFregsMFVALAASVFS 113
Cdd:cd15391   15 VGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALfcmpfTFTQIMLGHWVFPAPMCPIVLYV----QLVSVTASVLT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 114 LLAIAIERHLTMLkMKLHNNGKTCRVFMLISTVWFIAAILGGL-------PVMGWNCIDSInNCSTVLPlyHKAYILFCT 186
Cdd:cd15391   91 NTAIGIDRFFAVI-FPLRSRHTKSRTKCIIASIWAISFSLSSVqlfagrtQRYGQYSEGRV-LCGESWP--GPDTSRSAY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 187 TVFSVILMAIVILYARIYALVRTrSRKLVFRKVAN----GRGSNKSSEKsMALLKTVIIVLSCFIACWAPL--FILL--- 257
Cdd:cd15391  167 TVFVMLLTYIIPLLILTSTYGYV-GFRLWNRTAPGnadkGRDDMQIKSK-RKVIKMLVFVVLMFGICWLPLhlFNLVqdf 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 982742395 258 --LLDVACQTLTCSILYKAEWflaLAVLNSAMNPLIYTLTSNEMR 300
Cdd:cd15391  245 stVFRNMPQHTTRLIYGACHW---IAMSNSFVNPIIYLFMNDSFR 286
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
29-123 1.24e-08

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 55.37  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIL---LSGANTYKLTP--TQWFFregsm 103
Cdd:cd15224    5 LLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLagfLSQNKSISFVGcmTQLYF----- 79
                         90       100
                 ....*....|....*....|.
gi 982742395 104 FVALAASVFSLLAI-AIERHL 123
Cdd:cd15224   80 FLSLACTECVLLAVmAYDRYV 100
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
28-303 1.27e-08

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 55.55  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGvVYTANILLSGA--NTYKLTPTQWFFREGSMFV 105
Cdd:cd15209    4 ACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVA-IYPYPLILHAIfhNGWTLGQLHCQASGFIMGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 ALAASVFSLLAIAIERHL----TMLKMKLHNNGKTCrVFMLISTVWFIAAILGGLPVMGWNCIDSINNCsTVLPLYHKAY 181
Cdd:cd15209   83 SVIGSIFNITAIAINRYCyichSLQYDRLYSLRNTC-CYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSC-TFAQTVSTVY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 ILFCTTVFSVILMAIVIL-YARIYALVRTRSRklvfRKVANGRGSNKSSEKSMALLKTVIIVLscFIACWAPL-FILLLL 259
Cdd:cd15209  161 TITVVVIHFLLPLLIVSFcYLRIWVLVLQVRQ----RVKPDQRPKLKPADVRNFLTMFVVFVL--FAVCWAPLnFIGLAV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 982742395 260 DVACQTLTCSI---LYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15209  235 AINPKEMAPKIpewLFVASYFMAY--FNSCLNAIIYGLLNQNFRKEY 279
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-303 1.29e-08

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 55.47  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGAntyklTPTqWFFREGS------ 102
Cdd:cd15208    5 ALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDV-----TET-WFFGQVLckiipy 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 -MFVALAASVFSLLAIAIERHLTML-KMKLHNNGKTCRVFMLIstVWFI--------AAILGGLPVMGW-NCIDSINNC- 170
Cdd:cd15208   79 lQTVSVSVSVLTLSCIALDRWYAIChPLMFKSTAKRARVSILI--IWIVsllimipqAIVMECSRVVPLaNKTILLTVCd 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 171 -STVLPLYHKAY-ILFCTTVFSVILMAIVILYARIYALVRTR-----SRKLVFRKVANGRGSNKSSEKSM----ALLKTV 239
Cdd:cd15208  157 eRWSDSIYQKVYhICFFLVTYLLPLCLMILAYFQIFRKLWCRqipgtSSVVQRKWNKPRKSAVAAEEKQLrsrrKTAKML 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 982742395 240 IIVLSCFIACWAPLFILLLLDVACQTLTCSILYKAEWFLA---LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15208  237 IVVVIMFAICYLPVHLLNILRYVFGLFTVDRETIYAWFLFshwLVYANSAINPIIYNFMSGKFREEF 303
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
36-303 1.41e-08

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 55.20  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  36 CFIIL----ENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSgantykLTPTQWFFREGSMFVALA--- 108
Cdd:cd15054    8 CLIILltvaGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLN------ALYGRWVLARDFCPIWYAfdv 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ----ASVFSLLAIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIAAILGGLPV-MGWNCIDSINNCSTVLPLYHKAYI 182
Cdd:cd15054   82 mccsASILNLCVISLDRYLLIISPLRYKLRMTpPRALALILAAWTLAALASFLPIeLGWHELGHERTLPNLTSGTVEGQC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 183 LFCTTVFSVILMAIVILYARIYALVRTRSRKLVfrkvangrgsnkSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVA 262
Cdd:cd15054  162 RLLVSLPYALVASCLTFFLPSGAICFTYCRILL------------AARKALKASLTLGILLGMFFVTWLPFFVANVVQAV 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 982742395 263 CQTLTCSILYKAEWflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15054  230 CDCVSPGLFDVLTW---LGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
28-292 1.55e-08

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 55.38  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANillsgaNTYKLTPTQWFFREG----SM 103
Cdd:cd15390    4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVF------NFTYLLYNDWPFGLFyckfSN 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVA---LAASVFSLLAIAIERHLTMLKMKLHNNGKTCrVFMLISTVWFIAAILgGLPVMGWNCIDSINN--------CST 172
Cdd:cd15390   78 FVAittVAASVFTLMAISIDRYIAIVHPLRPRLSRRT-TKIAIAVIWLASFLL-ALPQLLYSTTETYYYytgsertvCFI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 173 VLP-----LYHKAYILFCTTVFSVI-LMAIVILYARIyalvrtrSRKLVFRKVANGRGSNKssEKSMA----LLKTVIIV 242
Cdd:cd15390  156 AWPdgpnsLQDFVYNIVLFVVTYFLpLIIMAVAYTRV-------GVELWGSKTIGENTPRQ--LESVRakrkVVKMMIVV 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 243 LSCFIACWAPLFILLLLDVACQTLTCS----ILYKAEWFLALAvlNSAMNPLIY 292
Cdd:cd15390  227 VVIFAICWLPYHLYFILTYLYPDINSWkyiqQIYLAIYWLAMS--NSMYNPIIY 278
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
29-302 1.81e-08

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 55.04  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvVYTANILLSGAntyKLTPTQWFFREG------- 101
Cdd:cd15389    5 VAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDIL---ITLLNTPFTLV---RFVNSTWVFGKImchlsrf 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMFVALAASVFSLLAIAIERH---LTMLKMKL-HNNGKTCrvfmlISTVWFIAAILgGLPVMGWNCIDSINN-------- 169
Cdd:cd15389   79 AQYCSVYVSTLTLTAIALDRHrviLHPLKPRItPCQGVVV-----IAIIWIMASCL-SLPHAIYQKLVEFEYsnertrsr 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 170 CSTVLP----LYHKAYILFCTTVFSVI-LMAIVILYARIyalvrtrSRKLVFRKV------ANGRGSNKSSEKSmalLKT 238
Cdd:cd15389  153 CLPSFPepsdLFWKYLDLATFILQYVLpLLIIGVAYTRV-------AKKLWLRNAigdvttEQYVAQRRKKKKT---IKM 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982742395 239 VIIVLSCFIACWAPLFILLLLDVACQTLTCSILYKAewFLALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15389  223 LMLVVLLFAICWLPLNCYHVLLSSHPIRSNSALFFA--FHWLAMSSTCYNPFIYCWLNDSFRSE 284
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
28-309 1.88e-08

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 54.96  E-value: 1.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLL-AGVVYTANILLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd15307    4 ALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMvAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTM-LKMKLHNNGKTCRVFMLISTVWFIAaILGGLPVMGWNCIDSINN-----CSTVLPLYHKA 180
Cdd:cd15307   84 CTASIMHLCTISVDRYLSLrYPMRFGRNKTRRRVTLKIVFVWLLS-IAMSLPLSLMYSKDHASVlvngtCQIPDPVYKLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 181 YILFCTTVFSVILMAIVILYARIYALVRTRSRKLVfrkvangRGSNKSSeksmallKTVIIVLSCFIACWAPLFILLLLD 260
Cdd:cd15307  163 GSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRII-------RLEQKAT-------KVLGVVFFTFVILWSPFFVLNLLP 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 982742395 261 VACQTLTCSILYKA-EWFLALAVLNSAMNPLIYTLTSNEMRRAFIKMLNC 309
Cdd:cd15307  229 TVCAECEERISHWVfDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLC 278
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
29-303 2.41e-08

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 54.19  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFI-ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvYTANILLSGANTYKltPTQWFFREG--SMFV 105
Cdd:cd15210    4 AVWGIVFMVVgVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLL----FCAFNLPLAASTFL--HQAWIHGETlcRVFP 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 AL-----AASVFSLLAIAIERHLTMLKMKLHNN--GKTCRVFMLISTVWFIAAILGGLPVMGWNCID---SINNCStVLP 175
Cdd:cd15210   78 LLryglvAVSLLTLVLITLNRYILIAHPSLYPRiyTRRGLALMIAGTWIFSFGSFLPLWLGIWGRFGldpKVCSCS-ILR 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 176 LYHK---AYILFcTTVFSVILMAIVILYARiyalvrtrsrklvfrkvangrgsnkssEKSMALLKTVIIVLSCFIACWAP 252
Cdd:cd15210  157 DKKGrspKTFLF-VFGFVLPCLVIIICYAR---------------------------REDRRLTRMMLVIFLCFLVCYLP 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 253 LFILLLLD----VACQTLTCSIlykaewflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15210  209 ITLVNVFDdevaPPVLHIIAYV---------LIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
33-301 2.42e-08

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 54.53  E-value: 2.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  33 IVCCFIILENVLVLLTIWrTKKFHKPMYYF-IGNLALSDLLAGV--VYTANILLSGANTYKLTPTQWFFREG---SMFVA 106
Cdd:cd15136    9 FVFLLALVGNIIVLLVLL-TSRTKLTVPRFlMCNLAFADFCMGIylGLLAIVDAKTLGEYYNYAIDWQTGAGcktAGFLA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAA---SVFSLLAIAIER--------HLTMlKMKLhnngKTCRVFMLIStvWFIAAILGGLPVMGwncIDSINNCSTVLP 175
Cdd:cd15136   88 VFSselSVFTLTVITLERwyaithamHLNK-RLSL----RQAAIIMLGG--WIFALIMALLPLVG---VSSYSKTSICLP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 176 L-----YHKAYILFCTTVFSVILMAIVILYARIYALVRtrsrklvfrkvaNGRGSNKSSEKSMAlLKTVIIVLSCFiACW 250
Cdd:cd15136  158 FetetpVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVR------------GSGRAANSNDTRIA-KRMALLVFTDF-LCW 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 982742395 251 APLFILLLLDVACQTLtcSILYKAEWFLALAV-LNSAMNPLIYTLTSNEMRR 301
Cdd:cd15136  224 APIAFFGLTAAFGLPL--ISVSNAKILLVFFYpLNSCANPFLYAIFTKQFRR 273
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
29-301 4.87e-08

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 53.76  E-value: 4.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV------VYTANILLSGANTYKLtpTQWFFregs 102
Cdd:cd14984    5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLtlpfwaVYAADGWVFGSFLCKL--VSALY---- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 mFVALAASVFSLLAIAIERHLTMLKM-KLHNNGKTCRVFmLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAY 181
Cdd:cd14984   79 -TINFYSGILFLACISIDRYLAIVHAvSALRARTLLHGK-LTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 ILFCTTVFSVI---------LMAIVILYARI-YALVRTRSRKlvfrkvangrgSNKSseksmalLKTVIIVLSCFIACWA 251
Cdd:cd14984  157 ATTWKTLLRLLqnilgfllpLLVMLFCYSRIiRTLLRARNHK-----------KHRA-------LRVIFAVVVVFFLCWL 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 982742395 252 PLFILLLLDVACQTL----TCS----ILYKAEWFLALAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd14984  219 PYNIVLLLDTLQLLGiisrSCElsksLDYALQVTESLAFSHCCLNPVLYAFVGVKFRK 276
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
30-292 5.80e-08

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 53.60  E-value: 5.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFII--LENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVytaNILLSGANTYKLtptQWF--------FR 99
Cdd:cd15384    4 IVVLAVMFVIsfIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFF---CIPSEAIWAYTV---AWLagntmcklVK 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 100 EGSMFvALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLIStvWFIAAIL------------GGLPVMGWNCIDS 166
Cdd:cd15384   78 YLQVF-GLYLSTYITVLISLDRCVAILYpMKRNQAPERVRRMVTVA--WILSPIFsipqavifhverGPFVEDFHQCVTY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 167 INNCSTVLPLYHKAYILFCTtvFSVILMAIVILYARIY-ALVRTRSRKLVFRKVANGRGSNKS---SEKSMALLKTVIIV 242
Cdd:cd15384  155 GFYTAEWQEQLYNMLSLVFM--FPIPLVIMVTCYVLIFiTLSKSSRDFQGLEIYTRNRGPNRQrlfHKAKVKSLRMSAVI 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 982742395 243 LSCFIACWAPLFILLLLDVACQTLTCSILYKaEWFLALAVLNSAMNPLIY 292
Cdd:cd15384  233 VTAFILCWTPYYVIMIWFLFFNPYPLNDILF-DVIFFFGMSNSCVNPLIY 281
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
29-303 8.32e-08

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 52.80  E-value: 8.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKP--MYYFIGNLALSDLLagvvYTANILLSGANTYKLT--PTQWFFREGSMF 104
Cdd:cd15002    4 ILLGVICLLGFAGNLMVIGILLNNARKGKPslIDSLILNLSAADLL----LLLFSVPFRAAAYSKGswPLGWFVCKTADW 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 ---VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGgLPVMGWNCIDSINN---CSTVLP--- 175
Cdd:cd15002   80 fghACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVASIWVPACLLP-LPQWLFRTVKQSEGvylCILCIPpla 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 176 -----LYHKAYILFcttVFSVILMAIVILYARIYALVRTRSRKlvfrkVANGRGSNKSSEKSMALLKTVIIvlscFIACW 250
Cdd:cd15002  159 hefmsAFVKLYPLF---VFCLPLTFALFYFWRAYGQCQRRGTK-----TQNLRNQIRSRKLTHMLLSVVLA----FTILW 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 251 APLFILLLLdVACQTLTCSILYKAEWFLA--LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15002  227 LPEWVAWLW-LIHIKSSGSSPPQLFNVLAqlLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-292 1.09e-07

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 52.84  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTK-KFHKPMYYFIGNLALSDLlagvvyTANILLSGANTYKLTPTQWFFreGS----- 102
Cdd:cd15190   15 VIYMLVFVLGLSGNGLVLWTVFRSKrKRRRSADTFIANLALADL------TFVVTLPLWAVYTALGYHWPF--GSflckl 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 ----MFVALAASVFSLLAIAIERHLTMLKmKLHNNGKTCRVFMLIST--VWFIAAILgGLPVM----------GWNCIDS 166
Cdd:cd15190   87 ssylVFVNMYASVFCLTGLSFDRYLAIVR-SLASAKLRSRTSGIVALgvIWLLAALL-ALPALilrttsdlegTNKVICD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 167 INNCSTVLPLYHKAYI----LFCTTV-FSVILMAIVILYariYALVRTRSRKlvFRKvangrGSNKSSEKSMALLKTVII 241
Cdd:cd15190  165 MDYSGVVSNESEWAWIaglgLSSTVLgFLLPFLIMLTCY---FFIGRTVARH--FSK-----LRRKEDKKKRRLLKIIIT 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 982742395 242 VLSCFIACWAP------LFILLLLDVAcqTLTCS---ILYKAE-WFLALAVLNSAMNPLIY 292
Cdd:cd15190  235 LVVTFALCWLPfhlvktLYALMYLGIL--PFSCGfdlFLMNAHpYATCLAYVNSCLNPFLY 293
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
29-303 1.19e-07

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 52.51  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIIL----ENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV---YTANILLSGanTYKLTPTQWFFREG 101
Cdd:cd15399    1 IVLILAYCSIILlgvvGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLclpFTLVYTLLD--EWKFGAVLCHLVPY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMFVALAASVFSLLAIAIERHLTMLkMKLHNNGKTCRVFMLISTVWFIAAILGG-------LPVMGWNCIDSINNCSTVL 174
Cdd:cd15399   79 AQALAVHVSTVTLTVIALDRHRCIV-YHLESKISKKISFLIIGLTWAASALLASplaifreYSVIEISPDFKIQACSEKW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAYilfcTTVFSV---ILMAIVILYARIYALVRTRSRklVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWA 251
Cdd:cd15399  158 PNGTLND----GTIYSVsmlLIQYVLPLAIISYAYIRIWTK--LKNHVSPGGGNDHYHQRRRKTTKMLVCVVVVFAVSWL 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 252 PLFIL-LLLDVACQTLTCSiLYKAEW--FLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15399  232 PFHAFqLASDIDSKVLDLK-EYKLIYtiFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
39-303 1.21e-07

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 52.33  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV----VYTANILlsgANTYKLTPTQWFFREGSMFVALAASVFSL 114
Cdd:cd15298   15 VVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAfsmnLYTVYII---KGYWPLGAVVCDLWLALDYVVSNASVMNL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 115 LAIAIERHLTMLKMKLHNNGKTCRVF-MLISTVWFIAAILGGLPVMGWNCI---DSINNCSTVLPLYHKAYILFCTTV-- 188
Cdd:cd15298   92 LIISFDRYFCVTKPLTYPARRTTKMAgLMIAAAWVLSFVLWAPAILFWQFVvgkRTVPDNQCFIQFLSNPAVTFGTAIaa 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 189 FSVILMAIVILYARIyALVRTRSRKLVfrkvangrgsnksseksmallKTVIIVLSCFIACWAPLFILLLLDVACQTLTC 268
Cdd:cd15298  172 FYLPVVIMTVLYIHI-SLASARERKVT---------------------RTIFAILLAFILTWTPYNVMVLVNTFCQSCIP 229
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 982742395 269 SILYKAEWFLALavLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15298  230 DTVWSIGYWLCY--VNSTINPACYALCNATFKKTF 262
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
29-302 1.47e-07

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 52.11  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFI--ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAgvvytanILLSGANTYKL-TPTQWFFRE----G 101
Cdd:cd15928    3 VTAVCSVLMLvgASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLI-------FLVLPLDLYRLwRYRPWRFGDllcrL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMFVA---LAASVFSLLAIAIERHLTM---LKMK-LHNNGktcRVFMLISTVWFIAAILGGlPVMGWNCIDSINNCSTVL 174
Cdd:cd15928   76 MYFFSetcTYASILHITALSVERYLAIchpLRAKvLVTRG---RVKLLIAVIWAVAIVSAG-PALVLVGVEHIQGQQTPR 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAY----------ILFCTTVFSVILMAIVILYARI-YALVRTRSRklvfrkvANGRGSNKSSEKSMALLKTVIIVL 243
Cdd:cd15928  152 GFECTVVnvssgllsvmLWVSTSFFFVPMVCLSLLYGLIgRALWDRRQR-------SRTAGASRRDNNHRQTVRMLAVIV 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982742395 244 SCFIACWAPLFILLLLDVACQTLTCSILYKAEWF----LALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15928  225 LAFVLCWLPFHVGRVIFNHSRASTKHLHYVSQYFnlvsFVLFYLSAAINPILYNLMSKRYRYA 287
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
39-296 1.66e-07

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 52.13  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLlagVVYTANIL--LSGANTYKLTPTQWFFR--EGSMFVALAASVFSL 114
Cdd:cd15385   15 VIGNSSVLLALYKTKKKASRMHLFIKHLSLADL---VVAFFQVLpqLCWDITYRFYGPDFLCRivKHLQVLGMFASTYML 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 115 LAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGlPVMGWNCIDSINNCSTV--------LPLYHKAYILFCT 186
Cdd:cd15385   92 VMMTADRYIAICHPLKTLQQPTKRSYLMIGSAWALSFILST-PQYFIFSLSEIENGSGVydcwanfiVPWGIKAYITWIT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 187 -TVFSVILMAIVILYARI-YALVR-----TRSRKLVFRKVANGRGSNKSSEKSM--ALLKTV---IIVLSCFIACWAPLF 254
Cdd:cd15385  171 iSIFVVPVIILLTCYGFIcYNIWRnikckTRRGLSDNALKNILLAVCVSSVKTIsrAKIRTVkmtFVIVLAYIVCWAPFF 250
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 982742395 255 ILLLLDVACQ----------TLTCSILykaewflaLAVLNSAMNPLIYTLTS 296
Cdd:cd15385  251 TIQMWSVWDQnfpwdesentAVTITAL--------LASLNSCCNPWIYMFFS 294
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
29-300 1.94e-07

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 51.69  E-value: 1.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIgNLALSDLLAGV---VYTANILLSGANTY-----KLTPTQWFFre 100
Cdd:cd15115    5 VVLSLTFLLGVPGNGLVIWVAGLKMKRTVNTIWFL-NLAVADLLCCLslpFSIAHLLLNGHWPYgrflcKLLPSIIVL-- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 gSMFvalaASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNcSTVLPLYHKA 180
Cdd:cd15115   82 -NMF----ASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGN-HTRCGYDFLV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 181 YILFCTTVFSVIL--MAIVILYARIYalvrtrsrklvfRKVANGRGSNKSSEksmaLLKTVIIVLSCFIACWAPLFIL-L 257
Cdd:cd15115  156 AITITRAVFGFLLplLIIAACYSFIA------------FRMQRGRFAKSQSK----TFRVIIAVVVAFFVCWAPYHIIgI 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 982742395 258 LLDVACQTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMR 300
Cdd:cd15115  220 LSLYGDPPLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFK 262
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
32-292 2.07e-07

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 51.72  E-value: 2.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL--LAGVVYTA-NIllsgANTYKLTPTQWFFR--EGSMFVA 106
Cdd:cd15380    8 IAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLvfVLGLPFWAeNI----RNQFNWPFGNFLCRviSGVIKAN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSI---NNCSTVLPLYHKAYIL 183
Cdd:cd15380   84 LFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVpdlNISACILLFPHEAWHF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 184 FCTTVFSV---ILMAIVILYARIYALVRTRSRKLVFRKVANGRgsnkSSEKSMALLKTVIIVlscFIACWAPLFILLLLD 260
Cdd:cd15380  164 ARRVELNIvgfLLPLAAIVFFNFHIIASLRERTEESRKRCGGL----KDTKATRLILTLVLM---FLVCWTPYHFFAFLD 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 982742395 261 VACQTLTCSILYkAEWFLAL--------AVLNSAMNPLIY 292
Cdd:cd15380  237 FLFQVEVIQGCF-WEEFIDLglqlanffAFANSCLNPVIY 275
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
29-302 2.39e-07

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 51.72  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGantyKLTPTQWFFREGSMF-VAL 107
Cdd:cd15920    5 VMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVAYQN----TAGPLSFCKIVGAFFyLNM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTMLkmklhnngKTCRVFMLISTVWFIAAI----LGGLPVMGWNCIDSINNCSTVLPLYH----- 178
Cdd:cd15920   81 YASILFLSLISLDRYLKII--------KPLQQFKIHTVPWSSAASggvwLLLLACMIPFLFESRNEGPCDNKCFHfrskg 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 ---KAYILFCTTVFSVILMAIVILYARIyalvrtrSRKLvfRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPL-- 253
Cdd:cd15920  153 ltaGGINLTAVVIFYILSLLFLYFYAKI-------SHKL--YKVSLGNAQQQIKKASKRAIIKTFIVLAIFIVCFVPYhi 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 254 ----FILLLLDVACQTLTCSILYKA-EWFLALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15920  224 vrvpYVLAQIDVISSLPWKQTLHIAnELVLCLSALNSCLDPIIYFFLSSSFRRA 277
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
39-303 2.44e-07

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 51.88  E-value: 2.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMY-YFIGNLALSDLLAGVV---YTANILLSGANTYKLTPTQWFFREgsmFVALAASVFSL 114
Cdd:cd15319   15 LLGNILVCAAVVRFRHLRSKVTnIFIVSLAVSDLFVALLvmpWKAVAEVAGYWPFGAFCDVWVAFD---IMCSTASILNL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 115 LAIAIERHLTMLKMKLHNNGKTCRV-FMLISTVWFIAAILGGLPVM----------------GWNCIDSINNCSTVLply 177
Cdd:cd15319   92 CVISVDRYWAISSPFRYERKMTQRVaLVMISVAWTLSVLISFIPVQlnwhkdsgddwvglhnSSISRQVEENCDSSL--- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAYILFCTTVFSVILMAIVIL-YARIYALVRTRSRKL-VFRKVANGRGSNKSS--------------EKSMALLKTVII 241
Cdd:cd15319  169 NRTYAISSSLISFYIPVAIMIVtYTRIYRIAQIQIRRIsSLERAAEHAQSCRSNridchhhtslrtsiKKETKVLKTLSV 248
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 242 VLSCFIACWAPLFILLLLDVACQT--------LTCSILYKAEWFLALAVLNSAMNPLIYTLTSnEMRRAF 303
Cdd:cd15319  249 IMGVFVCCWLPFFILNCMVPFCDRppadpdagLPCVSETTFDVFVWFGWANSSLNPIIYAFNA-DFRKVF 317
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
42-292 2.61e-07

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 51.33  E-value: 2.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  42 NVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagVVYTANILLsgantYKLTPTQWFFREGS-------MFVALAASVFSL 114
Cdd:cd14975   18 NSFVIWSILIKVKQRSVTMLLVLNLALADLA--VLLTLPVWI-----YFLATGTWDFGLAAckgcvyvCAVSMYASVFLI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 115 LAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLY----HKAYILFCTTV-- 188
Cdd:cd14975   91 TLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCKYRHysdgQLVFHLLLETVvg 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 189 FSVILMAIVILYARIYALVRTRSRklvfrkvangrgsnKSSEKSMALLKTVIIvlsCFIACWAPLFILLLLDVACQTLTC 268
Cdd:cd14975  171 FAVPFTAVVLCYSCLLRRLRRRRF--------------RRRRRTGRLIASVVV---AFAACWLPYHVGNLLEVVSELIGG 233
                        250       260       270
                 ....*....|....*....|....*....|...
gi 982742395 269 SIL-------YKAEWFL--ALAVLNSAMNPLIY 292
Cdd:cd14975  234 SKMagtlgkvAEAGRPIagALAFLSSSINPLLY 266
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
30-303 2.62e-07

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 51.38  E-value: 2.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLL--AGVVYTAnillsgantYKLTPTQWFFREGSMFVAL 107
Cdd:cd15971    6 IYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELfmLGLPFLA---------IQVALVHWPFGKAICRVVM 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 A-------ASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSIN---NCSTVLPLY 177
Cdd:cd15971   77 TvdginqfTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHgrsSCTIIWPGE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAY---ILFCTTVFSVILMAIVILYARIYALVRTRSrklvfRKVANGRGSNKSSEKSMAllKTVIIVLSCFIACWAPLF 254
Cdd:cd15971  157 SSAWytgFIIYTFILGFFVPLTIICLCYLFIIIKVKS-----SGIRVGSSKRKKSEKKVT--RMVSIVVAVFVFCWLPFY 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 982742395 255 ILLLLDVACQTLTCSILYKA-EWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15971  230 IFNVSSVSVSISPTPGLKGMfDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-159 3.42e-07

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 50.94  E-value: 3.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvYTANI-------LLSGANTYKLTP--TQWFFr 99
Cdd:cd13954    5 VLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDIC----YTSVTvpkmlanLLSGDKTISFSGclTQLYF- 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 982742395 100 egsmFVALAASVFSLLAI-AIERHLT-------MLKMklhnNGKTCrvFMLISTVWFIAAILGGLPVM 159
Cdd:cd13954   80 ----FFSLGGTECFLLAVmAYDRYVAichplhyPTIM----NKRVC--ILLAAGSWLIGFLNSLIHTV 137
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
39-292 3.89e-07

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 50.89  E-value: 3.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvVYTANILLSGAntYKLTPTQWFFREGSMF-------VALAASV 111
Cdd:cd15394   15 VVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDML---MCATCVPLTLA--YAFEPRGWVFGRFMCYfvflmqpVTVYVSV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 112 FSLLAIAIER-HLTMLKMKLHNNGKTCRvfMLISTVWFIAAILGGLPVMGWNCIDSINN----CSTVLPLYHKAYILF-C 185
Cdd:cd15394   90 FTLTAIAVDRyYVTVYPLRRRISRRTCA--YIVAAIWLLSCGLALPAAAHTYYVEFKGLdfsiCEEFWFGQEKQRLAYaC 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 186 TTV---FSVILMAIVILYARIYALVRTRsrkLVFRKVANGRgSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLL--- 259
Cdd:cd15394  168 STLlitYVLPLLAISLSYLRISVKLRNR---VVPGSMTQSQ-AEWDRARRRKTFRLLVVVVVAFAICWLPLHIFNVIrdi 243
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 982742395 260 --DVACQTLTCSILYKAEWFlalAVLNSAMNPLIY 292
Cdd:cd15394  244 diDLIDKQYFNLIQLLCHWL---AMSSACYNPFLY 275
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
42-292 3.97e-07

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 50.95  E-value: 3.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  42 NVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGAnTYKLTPTQWFFREGSMFVALA--ASVFSLLAIAI 119
Cdd:cd15386   18 NLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEI-TYRFQGPDLLCRAVKYLQVLSmfASTYMLIMMTV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 120 ERHLTM---LKmKLHNNGKtcRVFMLISTVWFIAAILgGLPVMGWNCIDSINNCSTVL--------PLYHKAYILFCTTV 188
Cdd:cd15386   97 DRYIAVchpLR-TLQQPSR--QAYLMIGATWLLSCIL-SLPQVFIFSLREVDQGSGVLdcwadfgfPWGAKAYITWTTLS 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 189 FSVILMAIVIL-YARI-YALVRTRSRKLVFRKVANGRG------SNKSSEKSMALLK------TVIIVLScFIACWAPLF 254
Cdd:cd15386  173 IFVLPVAILIVcYSLIcYEICKNLKGKTQTSRSEGGGWrtqgmpSRVSSVRTISRAKirtvkmTFVIVLA-YIACWAPFF 251
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 982742395 255 ILLLLDV----------ACQTLTCSILykaewflaLAVLNSAMNPLIY 292
Cdd:cd15386  252 SVQMWSVwdenapdedsSDFAFTITML--------LASLSSCCNPWIY 291
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
23-212 4.07e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 51.30  E-value: 4.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  23 GLKADSVVFIIvcCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGS 102
Cdd:cd15005    1 ALKLTTLGLIL--CVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIYGALSCKVIA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 MFVALAA--SVFSLLAIAIERHLTMLKMKLHN---NGKTCrvFMLISTVWFIAAILGGLPVMG---WNCIDSINNCStvl 174
Cdd:cd15005   79 FLAVLFCfhSAFTLFCIAVTRYMAIAHHRFYAkrmTFWTC--LAVICMAWTLSVAMAFPPVFDvgtYTFIREEDQCT--- 153
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 982742395 175 pLYHKAYILFCTTVFSVILMAIVIL----YARIYALVRTRSR 212
Cdd:cd15005  154 -FEHRSYKANDTLGFMLVLAVVIAAthlvYLKLLIFLRHHRK 194
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
30-303 4.38e-07

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 50.58  E-value: 4.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYY---FIGNLALSDLL--AGVVYTANILLSGAntykltptQWFFREG--S 102
Cdd:cd15338    6 VFGVICFLGIIGNSIVIYTIVKKSKFRCQQTVpdiFIFNLSIVDLLflLGMPFLIHQLLGNG--------VWHFGETmcT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 MFVALAA-----SVFSLLAIAIERHL-TMLKMKLHNNGKTCRVFMLISTVWfIAAILGGLPVMGWNCI----DSINNCST 172
Cdd:cd15338   78 LITALDTnsqitSTYILTVMTLDRYLaTVHPIRSTKIRTPRVAVAVICLVW-ILSLLSITPVWMYAGLmplpDGSVGCAL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 173 VLP------LYHKAYILFCTtvFSVILMAIVILYARIY-------ALVRTRSRKLVFRKVAngrgsnksseksmallKTV 239
Cdd:cd15338  157 LLPnpetdtYWFTLYQFFLA--FALPLVVICVVYFKILqnmastvAPLPQRSLRVRTKKVT----------------RMA 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982742395 240 IIVLSCFIACWAPLFILLLLDVACQTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15338  219 VAICLAFFICWAPFYILQLAHLSIDRPSLAFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
28-303 4.54e-07

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 50.89  E-value: 4.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLS--------GANTYKLTPtqwfFR 99
Cdd:cd15000    3 SSMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHdffqnyvlGSVGCKLEG----FL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 100 EGSMfvaLAASVFSLLAIAIERhLTMLKMKLHNNGKTCRVFMLISTVWfIAAILGGLP--------VMGWNCIDSiNNCS 171
Cdd:cd15000   79 EGSL---LLASVLALCAVSYDR-LTAIVLPSEARLTKRGAKIVIVITW-IVGLLLALPlaiyrsyrERQWKNFLE-TYCA 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 ---TVLPLYhkaYILFCTTVFSVILMAIVILYARIYaLVRTRSRKLVFRKVANGRGSNKSSeksmaLLKTVIIVLSCFIA 248
Cdd:cd15000  153 entQVLPIY---WHVIITVLVWLPLGIMLICYSAIF-WKLDKYERRVLRREHPSVVRYKKK-----AAKTLFIVLITFVV 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982742395 249 CWAPLFILLLL---DVACQTLTCSI--LYKAEWFLA--LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15000  224 CRIPFTALIFYrykLVPNDNTQNSVsgSFHILWFASkyLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
30-303 4.71e-07

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 50.88  E-value: 4.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFI----ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTAnillsgANTYKLTPTQWFFREGS--- 102
Cdd:cd14977    2 VIMSLSLVIfavgIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVP------LNAYNLLTKDWLFGDVMckl 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 ----MFVALAASVFSLLAIAIERHL----TMLKMKLHNNGKTCRVFMLIstvWFIAAILGGLPVMGWNCI---DSINNCS 171
Cdd:cd14977   76 vpfiQVTSLGVTVFSLCALSIDRYRaavnSMPMQTIGACLSTCVKLAVI---WVGSVLLAVPEAVLSTVAresSLDNSSL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVLPLY-HKAYILFCTTVFSVILMA----IVILYARIYALVRTRsrKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCF 246
Cdd:cd14977  153 TVCIMKpSTPFAETYPKARSWWLFGcyfcLPLAFTAVCYLLMAR--TLIRAAKEYTRGTKKHMKQRRQLAKTVLCLVLVF 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982742395 247 IACWAPLFIL--LLLDVACQTLTCSILYKAEWFLA---LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14977  231 AFCWLPEHISniLRATLYNEVLIDTRSTLDILDLIgqfLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
28-303 4.91e-07

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 50.68  E-value: 4.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSD--LLAGVVYTANILLSGantykltptQWFFreGSMFV 105
Cdd:cd15970    4 SFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADelLMLSVPFLVTSTLLR---------HWPF--GSLLC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 ALA---------ASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIaAILGGLPVMGWNCI----DSINNCS 171
Cdd:cd15970   73 RLVlsvdainmfTSIYCLTVLSIDRYIAVVHpIKAARYRRPTVAKMVNLGVWVF-SILVILPIIIFSNTapnsDGSVACN 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVLPLYHKAYI-LFCTTVFSVILMAIVILYARIYALVRTRSRKLVFRKvanGRGSNKSSEKSMALLktVIIVLSCFIACW 250
Cdd:cd15970  152 MQMPEPSQRWLaVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKA---GWQQRKRSERKITLM--VMMVVTVFVICW 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982742395 251 APLFILLLLDVACQTLTCSIlykAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15970  227 MPFYVVQLVSVFVGQHDATV---SQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
26-303 4.93e-07

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 50.62  E-value: 4.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  26 ADSVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGvVYTANILLSGA--NTYKLTPTQWFFREGSM 103
Cdd:cd15400    2 ALSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVA-LYPYPLVLVAIfhNGWALGEMHCKVSGFVM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFML-ISTVWF--IAAILGGLPVMGWNCIDSINNCSTVLPLYHKA 180
Cdd:cd15400   81 GLSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLyVCLIWAltVVAIVPNFFVGSLEYDPRIYSCTFVQTASSSY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 181 YILFCTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSeksmalLKTVIIVLSCFIACWAPL-FILLLL 259
Cdd:cd15400  161 TIAVVVIHFIVPITVVSFCYLRIWVLVIQVRRKVKSESKPRLKPSDFRN------FLTMFVVFVIFAICWAPLnLIGLAV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 982742395 260 DVACQTLTCSIlykAEWFLA----LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15400  235 AINPQEMAPKV---PEWLFVvsyfMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
28-303 1.02e-06

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 49.74  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTAnilLSGANTyklTPTQWFFRE-GSMFVA 106
Cdd:cd15086    4 AVFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTP---FSFAAS---TQGRWLIGEhGCRWYG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVF---SLLAIAI---ERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHK- 179
Cdd:cd15086   78 FANSLFgivSLISLAVlsyERYCTLLRPTEADVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSSYGPEGPGTTCSVQWTSr 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 -----AYILfCTTVFSVIL--MAIVILYARIYALVR--TRSRKLVFRKvangrgsnksseKSMALLKTVIIVLSCFIACW 250
Cdd:cd15086  158 sansiSYII-CLFIFCLLLpfLVMVYCYGRLLYAIKqvGKINKSTARK------------REQHVLLMVVTMVICYLLCW 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 982742395 251 APLFILLLLDV--------ACQTLTCSILYKAewflalavlNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15086  225 LPYGVMALLATfgkpglvtPVASIVPSILAKS---------STVVNPIIYVFMNKQFYRCF 276
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
49-303 1.09e-06

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 49.37  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  49 IWRTKKFhKPMYYFIGNLALSDLLAGVVYTANIllsganTYKLTPTQWFFREGSMFVALAA-------SVFSLLAIAIER 121
Cdd:cd15162   26 LFRTKKK-APAVIYMANLAIADLLLVIWLPFKI------AYHIHGNNWIFGEALCRLVTVAfygnmycSILLLTCISIDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 122 HLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCI-----DSINNCSTVLPLY----HKAYILFCTTVFSVI 192
Cdd:cd15162   99 YLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTiflpaLDITTCHDVLPEQllvgDWFYYFLSLAIVGFL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 193 LMAIVILYARIyalvrtrsrkLVFRKVANGRGSNKSSEKSMALlKTVIIVLSCFIACWAPLFILLLLDVACQTL-TCSIL 271
Cdd:cd15162  179 IPFILTASCYV----------ATIRTLAALEDENSEKKKKRAI-KLAATVLAIFIICFAPSNLLLLAHYSLISSsGTGHL 247
                        250       260       270
                 ....*....|....*....|....*....|...
gi 982742395 272 YKAEWF-LALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15162  248 YFAYLLaLCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
33-299 1.26e-06

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 49.42  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  33 IVCCFIILENVLVLLTI-WRTKKFHKPMYYFigNLALSDLLAGVVYTA-NILLSGANTYKLTPTQWFFREGSMFVALAAS 110
Cdd:cd15118    9 IVSTLGIVENLLILWVVgFRLRRTVISIWIL--NLALSDLLATLSLPFfTYYLASGHTWELGTTFCRIHSSIFFLNMFVS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 111 VFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNciDSINNCSTVLPLYHKaYILFCTT--- 187
Cdd:cd15118   87 GFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFR--DVIERKDGRKLCYYN-FALFSPSpdn 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 188 -------------------VFSVILMAIVILYARIYALVRTRSRKLVFRKVangrgsnksseksmallKTVIIVLSCFIA 248
Cdd:cd15118  164 nhpickqrqeglaisklllAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFV-----------------RLVVSVVVSFAL 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 249 CWAPLFILLLLDVAC--QTLTCSILYKAEWFLA-LAVLNSAMNPLIYTLTSNEM 299
Cdd:cd15118  227 CWAPYHIFSIIEVMAhnQHSLRPLVIQGLPFATtLAFLNSVLNPVLYVFSCPDF 280
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
28-303 1.35e-06

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 49.41  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvYTANI-LLSGANTYKLTPTQWFFREGSMF-- 104
Cdd:cd15974    4 PVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADEL----FMLGLpFLATQNAISYWPFGSFLCRLVMTvd 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 -VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCI-DSINNCSTVLP----LYH 178
Cdd:cd15974   80 gVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVqPDLNTCNISWPepvsVWS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 KAYILFCTTV-FSVILMAIVILYARIYALVRTRSRKLvfrkvangrGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILL 257
Cdd:cd15974  160 TAFIIYTAVLgFFGPLLVICLCYLLIVIKVKSSGLRV---------GSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLN 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 982742395 258 LLDVACQTLTCSILYKAEWF-LALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15974  231 IVNLIVILPEEPAFVGVYFFvVVLSYANSCANPILYGFLSDNFKQSF 277
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
29-307 1.42e-06

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 49.52  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLlTIWRTKKFHKPMYYFIGNLALSDLLAgVVYTANILLSGANTYKLTPTQWFFREGSMFVALA 108
Cdd:PHA02834  33 VFYILLFIFGLIGNVLVI-AVLIVKRFMFVVDVYLFNIAMSDLML-VFSFPFIIHNDLNEWIFGEFMCKLVLGVYFVGFF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVFSLLAIAIERHLTMLKMKLHNNgKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCST-VLPLYHK-----AYI 182
Cdd:PHA02834 111 SNMFFVTLISIDRYILVVNATKIKN-KSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQcIFNDYHEnfswsAFF 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 183 LFCTTVFSVILMAIVILYARIYALVRTRSRKlvfrkvangrgsNKSSEKSMALLKTVIIVLSCFiacWAPLFILL----- 257
Cdd:PHA02834 190 NFEINIFGIVIPLIILIYCYSKILYTLKNCK------------NKNKTRSIKIILTVVTFTVVF---WVPFNIVLfinsl 254
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 258 ----LLDVACQTLTcSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAFIKML 307
Cdd:PHA02834 255 qsvgLIDIGCYHFK-KIVYSIDIAELISFVHCCVNPIIYAFVGKNFKKVFKNMF 307
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
31-302 1.48e-06

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 48.98  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  31 FIIVCCFIilENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV--VYTANILLSGANtYKLTPTQWFFREGSMFVALA 108
Cdd:cd15012    8 LVFCCCFF--GNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIfcVLQNLSIYLIPS-WPFGEVLCRMYQFVHSLSYT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILG--------GLPVMGWNCIDSINNCSTVLPLYH- 178
Cdd:cd15012   85 ASIGILVVISVERYIAILHpLRCKQLLTAARLRVTIVTVWLTSAVYNtpyfvfsqTVEILVTQDGQEEEICVLDREMFNs 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 KAYILFCTTV-FSVILMAIVILYARIYALVRTRSRKLVFRKVangrgsnksseksmalLKTVIIVLSCFIACWAPLFILL 257
Cdd:cd15012  165 KLYDTINFIVwYLIPLLIMTVLYSKISIVLWKSSSIEARRKV----------------VRLLVAVVVSFALCNLPYHARK 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 982742395 258 LLDVACQTLTCS----ILYKAEWFLALaVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15012  229 MWQYWSEPYRCDsnwnALLTPLTFLVL-YFNSAVNPLLYAFLSKRFRQS 276
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-303 1.86e-06

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 48.77  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL-LAGVVYTANILLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd16003    4 SLAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDAsMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTM---LKMKLHNNGKTcrvfMLISTVWFIAAILgGLPvmgwNCIDSINN-------CSTVLPL 176
Cdd:cd16003   84 VFASIYSMTAIAVDRYMAIidpLKPRLSATATK----VVIGSIWILAFLL-AFP----QCLYSKTKvmpgrtlCFVAWPG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 YHKAYILFCTTVFSVILMAIVILYARIYALVRTRsrklVFRKVANGRGSNKSSEKSMA---LLKTVIIVLSCFIACWAPL 253
Cdd:cd16003  155 GPDQHFTYHIIVIVLVYCLPLLVMGITYTIVGIT----LWGGEIPGDTSDKYHEQLRAkrkVVKMMIIVVLTFAICWLPY 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 254 FILLLLDVACQTLT----CSILYKAEWFLALAvlNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd16003  231 HIYFIVTGLYQQLNrwkyIQQVYLASFWLAMS--STMYNPIIYCCLNKRFRAGF 282
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
28-301 2.07e-06

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 48.59  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagVVYTANILLSGANTYKltptQWFFREG----SM 103
Cdd:cd15193    4 PILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLV--FVLTLPFWAASTALGG----QWLFGEGlcklSS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 F---VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNC----STVLPL 176
Cdd:cd15193   78 FiiaVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLINESVCvedsSSRFFQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 YHKAYILFCTTVFSVILmaIVILYARIYAlvrtRSRKLVFRKVANGRGSNKSseksmalLKTVIIVLSCFIACWAPL--- 253
Cdd:cd15193  158 GISLATLFLTFVLPLIV--ILFCYCSILV----RLRRHFHGAKRTGRRRRNS-------LRIVFAIVTAFVLSWLPFntl 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982742395 254 -FILLLLDVACQTLTCSILYKAEWFLA----LAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15193  225 kAVRLLLELGGGVLPCHTTVAIRQGLTitacLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
32-303 2.13e-06

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 48.90  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCCFIILE---NVLVLLTIWR---TKKFHKPMyyFIGNLALSDLLAGVVYTAnilLSGAntYKLTpTQWFFREGS--- 102
Cdd:cd15383    5 AVTFVLFVLSacsNLAVLWSATRnrrRKLSHVRI--LILHLAAADLLVTFVVMP---LDAA--WNVT-VQWYAGDLAcrl 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 -MF---VALAASVFSLLAIAIERHLTMLKMKLHNNGKtCRVFMLISTVWFIAAILGgLPVM----------GWNCIDSIN 168
Cdd:cd15383   77 lMFlklFAMYSSAFVTVVISLDRHAAILNPLAIGSAR-RRNRIMLCAAWGLSALLA-LPQLflfhtvtatpPVNFTQCAT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 169 NCSTVLPLYHKAYILFC-TTVFSVILMAIVILYARIYALVRTRSRKLVFR---KVANGRGSNKSSEKSMALLKTVIIVLS 244
Cdd:cd15383  155 HGSFPAHWQETLYNMFTfFCLFLLPLLIMIFCYTRILLEISRRMKEKKDSaknEVALRSSSDNIPKARMRTLKMTIVIVS 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 982742395 245 CFIACWAPLFILLLLDVACQTLTCSIL--YKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15383  235 SFIVCWTPYYLLGLWYWFSPEMLEQTVpeSLSHILFLFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
39-205 2.94e-06

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 48.13  E-value: 2.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIL---LSGANT--YKLTPTQWFFregsmFVALA-ASVF 112
Cdd:cd15406   24 VVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLvnfVSEKNIisYPECMTQLFF-----FCVFAiAECY 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 113 SLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGwnCIDSINNCST---------VLPL------- 176
Cdd:cd15406   99 MLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTS--CMLRLSFCGDnvinhyfcdILPLlklscss 176
                        170       180       190
                 ....*....|....*....|....*....|..
gi 982742395 177 -YHKAYILFCTTVFSVIL--MAIVILYARIYA 205
Cdd:cd15406  177 tYINELLLFIVGGFNVLAttLAILISYAFILS 208
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
29-156 3.19e-06

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 48.17  E-value: 3.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTP-----TQWFFregsm 103
Cdd:cd15409    5 LVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISfsgcaAQFFF----- 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 104 FVALA-ASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGL 156
Cdd:cd15409   80 FGFSAtTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSM 133
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
28-303 3.34e-06

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 48.16  E-value: 3.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFiileNVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVytaNILLSGANTYKLtptQWFFREGS----M 103
Cdd:cd15195    8 WVLFVISAAG----NLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFF---NMPMDAVWNYTV---EWLAGDLMcrvmM 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FV---ALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLIS-TVWFIAAILGGL----------PVMGWNCID-SI 167
Cdd:cd15195   78 FLkqfGMYLSSFMLVVIALDRVFAILSpLSANQARKRVKIMLTVAwVLSALCSIPQSFifsvlrkmpeQPGFHQCVDfGS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 168 NNCSTVLPLYHkAYILFCTtvFSVILMAIVILYARI-YALVRTRSRKLVFRKVANGRGSNKSSE--KSMALLKTVIIVLS 244
Cdd:cd15195  158 APTKKQERLYY-FFTMILS--FVIPLIITVTCYLLIlFEISKMAKRARDTPISNRRRSRTNSLEraRMRTLRMTALIVLT 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 245 cFIACWAPLFILLLLDVACQTLTCSILYKAE-WFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15195  235 -FIVCWGPYYVLGLWYWFDKESIKNLPPALShIMFLLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
28-303 4.03e-06

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 47.70  E-value: 4.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG------VVYTANillsgantykltPTQWFFREG 101
Cdd:cd15168    4 PIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLlslpflIYYYAN------------GDHWIFGDF 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 -------SMFVALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILgGLPVMGWNCIDSINNCSTV 173
Cdd:cd15168   72 mcklvrfLFYFNLYGSILFLTCISVHRYLGICHpLRSLGKLKKRHAVAISVAVWILVLLQ-LLPILFFATTGRKNNRTTC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 174 LPL-------YHKAYILFCT-TVFSVILMAIVILYariYALVRTRSRKLvfrkvangrGSNKSSEKSMALLKTVIIVLSC 245
Cdd:cd15168  151 YDTtspeelnDYVIYSMVLTgLGFLLPLLIILACY---GLIVRALIRKL---------GEGVTSALRRKSIRLVIIVLAL 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 246 FIACWAPLFIL----LLLDVACQTLTCSILYKAEWFL----ALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15168  219 FAVCFLPFHVTrtinLAARLLSGTASCATLNGIYVAYkvtrPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
28-303 4.42e-06

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 47.93  E-value: 4.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLT--PTQWFFREGSMFV 105
Cdd:cd15357    4 SLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNYPFLfgPVGCYFKTALFET 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 ALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWfIAAILGGLPVMGWN-----------CIDSINNCSTV 173
Cdd:cd15357   84 VCFASILSVTTVSVERYVAILHpFRAKLNSTRERALKIIVVLW-VLSVLFSIPNTSIHgiklqyfpngtLIPDSATCTVV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 174 LPLYHKAYILFCTT-VFSVILMAIVILYARIYALVRTRSRKLvfrkVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAP 252
Cdd:cd15357  163 KPLWIYNLIIQITSlLFYVLPMGVISVLYYLMGLKLRGDKSL----EADEMNVNIQRPSRKSVTKMLFVLVLVFAICWAP 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 253 LFILLLLdvacqtltcsILYKAEWFLALA--------------VLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15357  239 FHVDRLF----------FSFVVEWTEPLAnvfnlihvvsgvffYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
28-303 4.89e-06

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 47.45  E-value: 4.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILlsgantYKLTPTQWFFREG------ 101
Cdd:cd15368    4 PVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIV------YHIQRNHWIFGKPlcnvvt 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMFVA-LAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWN------------CIDSIN 168
Cdd:cd15368   78 VLFYAnMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDltyyvkelnittCFDVLK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 169 ncSTVLPLYhKAYILFCTTVFSVILMAIVILYARIYALVrtrSRKLVFRKVANGRGSNKSSeksmalLKTVIIVLSCFIA 248
Cdd:cd15368  158 --WTMLPNI-AAWAAFLFTLFILLFLIPFIITVYCYVLI---ILKLVQTSERYGREQKRRA------IYLALIVLLVFIT 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 249 CWAPLFILLLLDVACQTLTCSILYKA-EWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15368  226 CFAPNNFILLAHMVSRLFYGKSLYHAyKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-303 5.12e-06

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 47.52  E-value: 5.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYK--LTPTQWFFREGSMFV 105
Cdd:cd15133    4 CLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYPflLGSGGCYFKTFLFET 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 ALAASVFSLLAIAIERHLTM---LKMKLHNNGKtcRVFMLISTVWFIAAI-------LGGLPVMGWNCIDSInNCSTVLP 175
Cdd:cd15133   84 VCLASILNVTALSVERYIAVvhpLAARTCSTRP--RVTRVLGCVWGVSMLcalpntsLHGIKFLGSGVPASA-QCTVRKP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 176 LYHKAYILFCTTV-FSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGS-----NKSSEKSMALLKTVIIVLSCFIAC 249
Cdd:cd15133  161 QAIYNMIPQHTGHlFFVLPMAVISVLYLLMALRLARERGLDATGAGSKIGTrtgqlLQHPRTRAQVTKMLFILVVVFAIC 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 982742395 250 WAPLFILLLLDVACQTLTCSIlykAEWFLALAV-------LNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15133  241 WAPFHIDRLMWSFISDWTDNL---HEVFQYVHIisgvffyLSSAVNPILYNLMSTRFREMF 298
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
29-295 5.51e-06

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 47.57  E-value: 5.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagVVYTANILLSgaNTYKLTPTqwFFREGSMFVALA 108
Cdd:cd15079    5 FIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFL--MMIKMPIFIY--NSFYEGWA--LGPLGCQIYAFL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVF------SLLAIAIERHLTMLK-MklhnNGKTC---RVFMLISTVWFIAAILGGLPVM-GWN----------C-IDS 166
Cdd:cd15079   79 GSLSgigsiwTNAAIAYDRYNVIVKpL----NGNPLtrgKALLLILFIWLYALPWALLPLLfGWGryvpegfltsCsFDY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 167 IN-NCSTvlplyhKAYILFCTTVFSVILMAIVIL-YARIYALVRTRSRKL--VFRK--VANGRGSNKSSEKS--MALLKT 238
Cdd:cd15079  155 LTrDWNT------RSFVATIFVFAYVIPLIIIIYcYSFIVKAVFAHEKALreQAKKmnVVSLRSNADANKQSaeIRIAKV 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 239 VIIVLSCFIACWAPLFILLLLDVA--CQTLT------CSILYKAewflalavlNSAMNPLIYTLT 295
Cdd:cd15079  229 ALTNVFLWFIAWTPYAVVALIGAFgnQSLLTplvsmiPALFAKT---------AACYNPIVYAIS 284
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
28-303 6.10e-06

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 47.13  E-value: 6.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKF-HKPMYYFIGNLALSDL--------LAGVVYTANILLSGANTYKLTPtqwFF 98
Cdd:cd15097    4 PVVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLcfilfcvpFQATIYSLEGWVFGSFLCKAVH---FF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  99 regsMFVALAASVFSLLAIAIERHLTmLKMKLHNNG--KTCRVFMLISTVWFIAAILGGlPVMGWNCIDSINNCSTVLPL 176
Cdd:cd15097   81 ----IYLTMYASSFTLAAVSVDRYLA-IRYPLRSRElrTPRNAVAAIALIWGLSLLFAG-PYLSYYDLIDYANSTVCMPG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 YHKA---YILFCTTVFSVILMAIVIlyariyALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPL 253
Cdd:cd15097  155 WEEArrkAMDTCTFAFGYLIPVLVV------SLSYTRTIKYLWTAVDPLEAMSESKRAKRKVTKMIIIVTALFCLCWLPH 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 254 FILLL------LDVACQTLTCSILYKAewflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15097  229 HVVILcylygdFPFNQATYAFRLLSHC-----MAYANSCLNPIVYALVSKHFRKGF 279
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
29-303 7.80e-06

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 47.00  E-value: 7.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV-----YTANIL---LSGANTYKLTPtqwFFre 100
Cdd:cd15206    5 PLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFcmpftLVGQLLrnfIFGEVMCKLIP---YF-- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 gsMFVALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWfIAAILGGLPVMGWNCIDSINN-----CSTVL 174
Cdd:cd15206   80 --QAVSVSVSTFTLVAISLERYFAICHpLKSRVWQTLSHAYKVIAGIW-LLSFLIMSPILVFSNLIPMSRpgghkCREVW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PL--YHKAYILFCTTVFSVILMAIVILyarIYALVrtrSRKLVFRKVangrgsnksseksmALLKTVIIVLSCFIACWAP 252
Cdd:cd15206  157 PNeiAEQAWYVFLDLMLLVIPGLVMSV---AYGLI---SWTLLEAKK--------------RVIRMLFVIVVEFFICWTP 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 253 LFIL-----LLLDVACQTLTCSILykaEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15206  217 LYVIntwkaFDPPSAARYVSSTTI---SLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
30-303 8.76e-06

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 46.77  E-value: 8.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagVVYTANILLSGANTYKLTPTQWFFRE--GSMFVAL 107
Cdd:cd15973    6 IYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADEL--FMLSVPFLAASAALQHWPFGSAMCRTvlSVDGINM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVL------PLYHKAY 181
Cdd:cd15973   84 FTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACnliwphPAWSAAF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 ILFCTTV-FSVILMAIVILYARIYALVRTRSRKLvfrkvanGRGSNKSSEKSmaLLKTVIIVLSCFIACWAPLFILLLLD 260
Cdd:cd15973  164 VIYTFLLgFLLPVLAIGLCYILIIGKMRAVALKA-------GWQQRRKSEKK--ITRMVLMVVTVFVICWMPFYVVQLLN 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 982742395 261 VACQTLTCSILYKAewfLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15973  235 LFLPRLDATVNHAS---LILSYANSCANPILYGFLSDNFRRSF 274
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
42-301 1.16e-05

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 46.36  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  42 NVLVLLTIWRTKKFHKPMYYFIGNLALSDLLA---GVVYTANILLSGANTYKLTPTQWFFREGSMFVALaaSVFSLLAIA 118
Cdd:cd15078   18 NLLVLILYYKFKRLRTPTNLLLVNISLSDLLVsllGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIV--SIMTLTVLA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 119 IERHLTMLKMKLHNNGKTCRVfmlISTVWFIAAILGGLPVMGWNC-------IDSINNCSTVLPLYHKAYILFCTTVFSV 191
Cdd:cd15078   96 YERYIRVVHAKVVNFSWSWRA---ITYIWLYSLAWTGAPLLGWNRytlevhgLGCSFDWKSKDPNDTSFVLLFFLGCLVV 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 192 ILMAIVILYARIYALVRtrsrklVFRKVANGRGSNKSS----EKSMAllKTVIIVLSCFIACWAPLFILLLLDVACQ--- 264
Cdd:cd15078  173 PLGIMAYCYGHILYEIR------MLRSVEDLQTFQVIKilkyEKKVA--KMCLLMISTFLICWMPYAVVSLLVTSGYskl 244
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 982742395 265 -TLTCSILYKaewflALAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15078  245 vTPTIAIIPS-----LFAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
28-303 1.28e-05

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 46.43  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKP-MYYFIGNLALSDLlAGVVYTANILLSGANTYKltptqWFFREG----- 101
Cdd:cd15926    4 SIVYSVVCALGLVGNLLVLYLMKSKQGWKKSsINLFVTSLAVTDF-QFVLTLPFWAVENALDFT-----WLFGKAmckiv 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMFVA--LAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWfIAAILGGLP---------VMGWN-CI---- 164
Cdd:cd15926   78 SYVTAmnMYASVFFLTAMSVARYHSVASaLKSKRRRGCCSAKWLCVLIW-VLAILASLPnaifsttatVSNEElCLvkfp 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 165 DSINNCSTVLPLYHKAYILFCttvFSVILMAIVILYAriyalvrtrsrkLVFRKVANGRGSNKSSEKSMALLKTVIIVLS 244
Cdd:cd15926  157 DNRGNAQFWLGLYHAQKVLLG---FLIPLGIISLCYL------------LLVRFITDKNITGSSTKRRSKVTKSVTIVVL 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 982742395 245 CFIACWAP---------LFILLLLDVACQTLTCSIlYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15926  222 SFFLCWLPnqalttwgiLIKLNVVHFSYEYFTTQV-YIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
109-303 1.40e-05

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 46.33  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWfIAAILGGLPV---MG---------------WNCIDSINNC 170
Cdd:cd15135   91 ATILNVATLSFERYIAICHPFKYKALSGSRVRLLICFVW-LTSALVALPLlfaMGtedpleafpsyrgtrHHCQDQKSNL 169
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 171 STVLPLYHKaYILFCTTVFSVILMAIVILyARIYALVRTRSRKLVFRK-----VANGRGS-----NKSSEKSMALLKTVI 240
Cdd:cd15135  170 TICTSLSSK-WTVFQASIFSAFVLYLLVL-ASVAFMCRRMMRALMGSKkgavaVKGPGGSvqllrKHESAEGKTARKQTI 247
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982742395 241 IVLSCFIA----CWAPLFILLLLDVACQTLTCSILYKAEWFLALAV------LNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15135  248 LFLGLIVGtlavCWMPNQIRRIMAAAKPKDDWTRSYFRAYIILLPIadtffyLSSVLNPLLYNLSSQQFRSVF 320
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
26-301 1.64e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 45.70  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  26 ADSVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFV 105
Cdd:cd15214    1 TESIAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 ALA-ASVFSLLAIAIERHLTML-----KMKLHNNgktcRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHK 179
Cdd:cd15214   81 LISsASMLTLGAIAIDRYYAVLypmvyPMKITGN----RAVLALVYIWLHSLIGCLPPLFGWSSLEFDRFKWMCVAAWHK 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 --AYILFCTTVFSVI-LMAIVILYARIYALVRTRSRKLvfrkvangrgsnksseksmalLKTVIIVLSCFIACWAPLFIL 256
Cdd:cd15214  157 eaGYTAFWQVWCALLpFVVMLVCYGFIFRVARANQCKA---------------------FITILVVLGAFVTTWGPYMVV 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 982742395 257 LLLDV--ACQTLTCSILYKAEWflaLAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15214  216 ISTEAlwGKNSVSPQLETLATW---LSFTSAVCHPLIYGLWNKTVRK 259
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
29-152 1.86e-05

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 45.71  E-value: 1.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIL---LSGANT--YKLTPTQWFFregsM 103
Cdd:cd15232    5 WLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLqnlLTERKTisFGGCMAQLYF----F 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 982742395 104 FVALAASVFSLLAIAIERHLTM---LKMKLHNNGKTCrvFMLISTVWFIAAI 152
Cdd:cd15232   81 TWSLGSELLLLTAMAYDRYVAIchpLHYSTIMRKEVC--VGLATGVWAIGML 130
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
29-305 2.95e-05

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 45.16  E-value: 2.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILL-----SGANTYKLTPTQWFFREGSM 103
Cdd:cd15418    6 VVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILAdciskDKSISFAGCAAQFFFSAGLA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FvalaASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGG---------LPVMGWNCIDSInnCSTVL 174
Cdd:cd15418   86 Y----SECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAiihtsntfrLHFCGDNIIDHF--FCDLP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKA--------YILFCTTVFSVILMAIVIL--YARIY-ALVRTRSRKlvfrkvangrGSNKSSEKSMALLKTVIIVL 243
Cdd:cd15418  160 PLVKLAcddtrvyeLILYFILGFNVIAPTALILasYTFILaAILRIHSAS----------GRHKAFSTCSAHLTSVTLYY 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 244 SCFiacwapLFILllldvacqtLTCSILYKAEWFLALA----VLNSAMNPLIYTLTSNEMRRAFIK 305
Cdd:cd15418  230 GSI------LFIY---------SRPSSSHTPDRDKVVAlfytVVNPLLNPLIYSLRNKDVKEALKK 280
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
28-122 2.98e-05

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 44.98  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLS---GANTYKLTP--TQWFFREgs 102
Cdd:cd15223    4 SLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIfwfDANTISLPGcfAQMFFIH-- 81
                         90       100
                 ....*....|....*....|
gi 982742395 103 MFVALAASVfsLLAIAIERH 122
Cdd:cd15223   82 FFTAMESSI--LLVMALDRY 99
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
28-307 3.40e-05

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 45.15  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLlTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVAL 107
Cdd:PHA03087  44 IVVYSTIFFFGLVGNIIVI-YVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGF 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYH------KAY 181
Cdd:PHA03087 123 YNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNnktmnwKLF 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 ILFCTTVFSVILMAIVILYARIYALVRTrsrklvfrkvangRGSNKSSEKSMAlLKTVIIVLSCFIACWAPLFILLLLDV 261
Cdd:PHA03087 203 INFEINIIGMLIPLTILLYCYSKILITL-------------KGINKSKKNKKA-IKLVLIIVILFVIFWLPFNVSVFVYS 268
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 262 A--------CQTLT--CSILYKAEwflALAVLNSAMNPLIYTLTSNEMRRAFIKML 307
Cdd:PHA03087 269 LhilhfksgCKAVKyiQYALHVTE---IISLSHCCINPLIYAFVSEFFNKHKKKSL 321
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
29-296 3.45e-05

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 44.77  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANI--LLSGANtYKLTPTQWFFREGSMFVA 106
Cdd:cd15365    5 FVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIdyLWNGDN-WTLSGFVCIFSAFLLYTN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNciDSINNCSTVLPLYHK------- 179
Cdd:cd15365   84 FYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWE--DSFHESSSHTLCYDKfpledwq 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 ---AYILFCTTvFSVILMAIVILYARIYALVRTrsrklvfrkvaNGRGSNKSSEKSMALLKTVIIvlsCFIACWAPLFIL 256
Cdd:cd15365  162 arlNLFRICLG-YLLPLLIILFCYWKIYQAVRS-----------NQATEDQEKKKIFKLLLLITV---TFVICFTPYHVV 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 982742395 257 LLLDVACQTLTC----SILYKAEWFLALAVLNSAMNPLIYTLTS 296
Cdd:cd15365  227 LLIRSIVEPCDCrnakWLYTLYKITVALTSLNCIADPFLYCFVT 270
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
30-294 3.78e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 44.81  E-value: 3.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIIL----ENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGAnTYKLTPTQWFFR--EGSM 103
Cdd:cd15387    2 VEVTVLALILFlaltGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQLIWDI-TFRFYGPDFLCRlvKYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLIStvWFIAaILGGLPVMGWNCIDSINN------CSTVLPLY 177
Cdd:cd15387   81 VVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYVLFS--WLLS-LVFSIPQVHIFSLREVGNgvydcwADFIQPWG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAYILFCTtvFSVILMAIVILyARIYALVRTR---SRKLVFRKVANGRGSNKSSEKSM------------ALLKTV--- 239
Cdd:cd15387  158 PKAYITWIT--LSVYIIPVLIL-SVCYGLISFKiwqNVKLKTRRETKTPLSSAASGGAAlarvssvkliskAKIRTVkmt 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 240 -IIVLScFIACWAPLFILLLLDV----ACQTLTCSILYkaewfLALAVLNSAMNPLIYTL 294
Cdd:cd15387  235 fVIVLA-YIVCWTPFFFVQMWSVwdpnAPKEASPFIIA-----MLLASLNSCCNPWIYMF 288
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
29-117 4.32e-05

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 44.75  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDllagVVYTANI-------LLSGANTYKLT--PTQWFFr 99
Cdd:cd15225    5 VVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLE----ICYTSVIvpkmlvnLLSEDKTISFLgcATQMFF- 79
                         90
                 ....*....|....*...
gi 982742395 100 egsmFVALAASVFSLLAI 117
Cdd:cd15225   80 ----FLFLGGTECFLLAA 93
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-303 4.40e-05

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 44.83  E-value: 4.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTA-NILLSGANTYKLTPTQWFFREGSMFVALAASVFSLLAI 117
Cdd:cd16004   15 VTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAfNFVYASHNDWYFGLEFCRFQNFFPITAMFVSIYSMTAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 118 AIERHLTMLK-MKLHNNGKTCRVfmLISTVWFIAAILgGLPVMGWNCI---DSINNCSTVLP---------LYHKAYILF 184
Cdd:cd16004   95 AADRYMAIIHpFKPRLSAGSTKV--VIAGIWLVALAL-AFPQCFYSTVtmdQGRTKCIVAWPgdsggkhqlTYHLAVIVL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 cttVFSVILMAIVILYARIyalvrtrSRKLVFRKVA--NGRGSNKSSEKSM-ALLKTVIIVLSCFIACWAPLFILLLL-- 259
Cdd:cd16004  172 ---IYLLPLAVMFVTYSII-------GITLWRSAVPghQAHGAYHRQLQAKkKFVKTMVVVVVTFAICWLPYHLYFILgs 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 982742395 260 ---DVACQTLTCSILYKAEWflaLAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd16004  242 fneDIYCQKYIQQVYLAIFW---LAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
30-253 4.97e-05

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 44.34  E-value: 4.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVC-CFII----LENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAG-------VVYT-ANILLSGANTYKLTPtqw 96
Cdd:cd15397    1 VFLVVSySLVMavglLGNICLICVIARQKEKTNVTNILIANLSFSDILVClvclpftVVYTlMDYWIFGEVLCKMTP--- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  97 FFREGSMFValaaSVFSLLAIAIERHltmlKMKLHNNG---KTCRVFMLISTVWFIAAILgGLPVMGWNC---------- 163
Cdd:cd15397   78 FIQCMSVTV----SILSLVLIALERH----QLIINPTGwkpSVSQAYLAVVVIWMLACFI-SLPFLAFHIltdepyknls 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 164 --IDSINN---CSTVLPLYHKAYIlFCTTV----FSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNksSEKSMA 234
Cdd:cd15397  149 hfFAPLADkavCTESWPSEHHKLA-YTTWLllfqYCLPLLFILVCYLRIYLRLRRRKDMLERRGEYNRRAGH--SKRINV 225
                        250
                 ....*....|....*....
gi 982742395 235 LLKTVIIVlscFIACWAPL 253
Cdd:cd15397  226 MLVSLVAA---FALCWLPL 241
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
29-300 5.04e-05

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 44.35  E-value: 5.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVL---VLLTiwRTKKFhkPMYYFIGNLALSDLLAGVVYTANIllsganTYKLTPTQWFFREGSMFV 105
Cdd:cd15372    5 SLYTLVFLVGLPANGLalwVLAT--QVKRL--PSTIFLINLAVADLLLILVLPFKI------SYHFLGNNWPFGEGLCRV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 ALAA-------SVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVM----GWNCIDS-INNCSTV 173
Cdd:cd15372   75 VTAFfygnmycSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTlqrqSYPLERLnITLCHDV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 174 LPL----YHKAYILFCTTVFSVILMAIVILYARIyALVRTRSRklvfrkvangrgsnkSSEKSMALLKTVIIVLSCFIAC 249
Cdd:cd15372  155 LPLdeqdTYLFYYFACLAVLGFLLPLVVILFCYG-SVLHTLLR---------------SGQRYGHAMKLTVLVLVSFVLC 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982742395 250 WAPLFILLLLDVACQTL-TCSILYKAEWF-LALAVLNSAMNPLIYTLTSNEMR 300
Cdd:cd15372  219 FTPSNLLLLLHYSDPTLdDGGNLYIVYMVsLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
28-252 5.51e-05

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 44.51  E-value: 5.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREG-SMFVA 106
Cdd:cd15081   16 SVWMIFVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGfTVSVC 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTMLKM--KLHNNGKTCRVFMLISTVWfiAAILGGLPVMGW----------NCIDSINNCSTVL 174
Cdd:cd15081   96 GITGLWSLTIISWERWVVVCKPfgNIKFDGKLAIVGIIFSWVW--SAVWCAPPIFGWsrywphglktSCGPDVFSGSSDP 173
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 175 PLyhKAYILFCTTVFSVILMAIVIL-YARIYALVRTRSRKlvfrkvANGRGSNKSSEKSMALLKTVIIVLSCFiaCWAP 252
Cdd:cd15081  174 GV--QSYMIVLMITCCIIPLAIIILcYLQVWLAIRAVAQQ------QKESESTQKAEKEVSRMVVVMIFAYCF--CWGP 242
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
42-301 6.35e-05

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 44.33  E-value: 6.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  42 NVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVALAASVFSLLAIAIER 121
Cdd:cd15152   18 NVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYASIYFLVCISVRR 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 122 HLTMLK-MKLHNNGKTCRVFmlISTVWFIAAILGGL--PVMGWNCIDSINNCSTVLPLYHkayilfCTTVFSVILMAIVI 198
Cdd:cd15152   98 CLYLIYpFRYNDCKRKCDVY--ISIAGWLVVCVGCLpfPLLRQSQDTNPTCCFADLPLRN------VGLTTSVIMLTIAE 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 199 LYARIYAL--VRTRSRKLVFRKVANGRGSNKSSEKSMALlKTVIIVLSCFIACWAPLFILLLLDVACQT---LTCS---- 269
Cdd:cd15152  170 LTGFVTPLliVLYCSWKTVMSLREKTPVLQDLGEKKKAL-KMILTCAVVFLICFAPYHISFPLDFLVKSnkiKSCTarkv 248
                        250       260       270
                 ....*....|....*....|....*....|..
gi 982742395 270 ILYKAEWFLALAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15152  249 ILIFHPVALCLASLNSCLDPVIYYFTTDEFKR 280
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
29-300 7.04e-05

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 44.02  E-value: 7.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVL-LTIWRTKKFHkPMYYFIGNLALSDLLAGVVYTANIllsganTYKLTPTQWFFRE------- 100
Cdd:cd15370    5 IVYIIVFVVGLPSNAMALwVFLFRTKKKH-PAVIYMANLALADLLFVIWFPLKI------AYHINGNNWIYGEalckvli 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 GSMFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWfIAAILGGLPVMGWNCIDSINN-----CSTVLP 175
Cdd:cd15370   78 GFFYGNMYCSILFMTCLSVQRYWVIVNPMSHSRKKANIAIGISLAIW-LLILLVTIPLYLVKQTVFIPAldittCHDVLP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 176 ---LYHKAYILFCTtvfsvilMAIVILYarIYALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAP 252
Cdd:cd15370  157 eqlLVGDMFNYFLS-------LAIGVFL--FPAFLTAVAYVLMIRALKSSINDESIEKKRKRAIKLIVTVLVMYLICFTP 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 982742395 253 LFILLLLDVACQTLTCSILYKAEWF--LALAVLNSAMNPLIYTLTSNEMR 300
Cdd:cd15370  228 SNLLLVVHYFLLKNQGQSSVYAFYItaLCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
29-211 7.50e-05

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 43.75  E-value: 7.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLlagvVYTANIL-LSGANTYKLTPTQWF---FREGSMF 104
Cdd:cd15431    5 VLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDI----CYTTSSVpQMLVNCLSDRPTISYsrcLAQMYIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALAASVFSLLAI-AIERHLTM---LKMKLHNNGKTCrvFMLISTVWFIAAILGGLPVMG---WNCIDS-INNCSTVLPL 176
Cdd:cd15431   81 LFLGITECLLLAVmAYDRFVAIcnpLRYTLIMSWRVC--IQLAAGSWVSAFLLTVIPVLTmplHFCGPNvINHFFCEVQA 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 YHKayiLFCT-TVFSVILMA-------------IVILYARI-YALVRTRS 211
Cdd:cd15431  159 LLK---LACSdTSLNEILMFatsiftlllpfsfILVSYIRIgVAVLRIRS 205
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
28-300 8.96e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 43.69  E-value: 8.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVAL 107
Cdd:cd15085    4 SFLMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 A-ASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSIN-NCSTVLPLYHKAY---- 181
Cdd:cd15085   84 GiVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGvQTSCSIGWEERSWsnys 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 --ILFCTTVFSVILMAIVILYARIyalvrTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIaCWAPLFILLLL 259
Cdd:cd15085  164 ylILYFLMCFVIPVAIIGFSYGNV-----LRSLHKLNKKIEQQGGKNCPEEEERAVIMVLAMVIAFLI-CWLPYTVFALI 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 982742395 260 DVACQTLTCSILyKAEWFLALAVLNSAMNPLIYTLTSNEMR 300
Cdd:cd15085  238 VVVNPELSISPL-AATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
25-303 9.78e-05

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 43.63  E-value: 9.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  25 KADSVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvytANILLSGANTYKLTPTQWFFREGS-- 102
Cdd:cd15199    1 IAYASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVL------LLICLPFKAYFYLNGNRWSLGGGTck 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 -----MFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLY 177
Cdd:cd15199   75 allfmLSLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQPKNFTECNSFSPKD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAY------ILFCTTvFSVILMAIVILYARIYALVRTRSRKLvfrkvangrGSNKSSEKSMALLKTVIIVLS-CFIACW 250
Cdd:cd15199  155 DEDFsdtwqeAVFFLQ-FLLPFGLIVFCTVRIIRRLKKRLRDV---------GKQPKLQRAMALVTSVVVVFGfCFLPCF 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 251 -APLFILLLLDVACQTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15199  225 lARVLMLIFQNKESCNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
30-301 1.07e-04

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 43.60  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIllsganTYKLTPTQWFFREGSMFVALAA 109
Cdd:cd15369    6 VYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKI------AYHFSGNDWLFGEAMCRVVTAA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 110 -------SVFSLLAIAIERHL-TMLKMKLHNNGKTCRVFMLISTVWFIaAILGGLPVMGWN------------CIDSINn 169
Cdd:cd15369   80 fycnmycSILLMTCISVDRFLaVVYPMQSLSWRTLRRASFTCAAIWLL-SIAGVVPLLLSEqtiqipdlgittCHDVLN- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 170 cSTVLPLYHKAYI-LFCTTVFSVILMAIVILYARIyalVRTRSRKlvfrkvangRGSNKSSEKSMALLKTViIVLSCFIA 248
Cdd:cd15369  158 -EQLLMGYYVYYFsIFSCLFFFVPLIITTVCYVSI---IRCLSSS---------SDVANSSKKTRALFMAV-AVFCVFVI 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 249 CWAPLFILLLLDVA--CQTLTCSILYKAEW-FLALAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15369  224 CFGPTNVLLLAHYVrfAYTSTNDASYFAYLlCVCVGSISCCLDPLIYYYGSSQCQK 279
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
29-117 1.12e-04

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 43.24  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvYTANIL-------LSGANTYKLTP--TQWFFr 99
Cdd:cd15911    5 LLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEIC----YTSTILprmlaslLTGDRTISVSGciVQFYF- 79
                         90
                 ....*....|....*...
gi 982742395 100 egsmFVALAASVFSLLAI 117
Cdd:cd15911   80 ----FGSLAATECYLLAV 93
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
29-292 1.37e-04

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 43.12  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFiiLENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV---YTANILLSGANTYKLTPTQWFFREGSMFV 105
Cdd:cd15213    7 MILMIFVGF--LGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVcmpFAAVTIITGRWIFGDIFCRISAMLYWFFV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 AlaASVFSLLAIAIERHLTMLKMKLHNNgkTCRVFMLISTVWFIAAILGGLPVMGW----------NCIDSINNcstvlP 175
Cdd:cd15213   85 L--EGVAILLIISVDRYLIIVQRQDKLN--PHRAKILIAVSWVLSFCVSFPPLVGWgkyefpprapQCVLGYTE-----S 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 176 LYHKAYILFcTTVFSVILMAIVILYARIYALVRTRSrklvFRKVAngrgsnksseksmalLKTVIIVLSCFIACWAPLFI 255
Cdd:cd15213  156 PADRIYVVL-LLVAVFFIPFLIMLYSYFCILNTVRS----FKTRA---------------FTTILILFIGFSVCWLPYTV 215
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 982742395 256 LLLLDV--ACQTLTCSIlykAEWFLALAVLNSAMNPLIY 292
Cdd:cd15213  216 YSLLSVfsRYSSSFYVI---STCLLWLSYLKSAFNPVIY 251
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
30-71 1.43e-04

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 43.21  E-value: 1.43e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL 71
Cdd:cd15916    6 IFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDM 47
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
116-305 1.49e-04

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 43.22  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 116 AIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIAAILGGLPVMG-----------WNCIDSINNCSTVLPLYhkaYIL 183
Cdd:cd15144  101 AMAVERCVGVTRPLLHSSVVTtTRTKLSLLAIWAVALAVALLPLFRfgrykpqfpgtWCFIKVQPPGSWADVAF---ALL 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 184 FCTTVFSVILMAIVILYARIYALVRTRSRKlvfrKVANGRGSNKSSEKSMALLKTVIIVLSCFiaCWAPLFILLLLDVAC 263
Cdd:cd15144  178 FSLLGLASLLVSLVCNTISGLTLVRARLRK----KCSCSNRRAKSHDIEMVVQLVGIMVVSCI--CWSPLLIFVLISVSR 251
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 982742395 264 QTLTCSILYKAEWFLA--LAVLNSAMNPLIYTLtsneMRRAFIK 305
Cdd:cd15144  252 SYERPKHQYEKLLFLGvrLASWNQILDPWVYIL----LRRAVLR 291
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
28-71 1.55e-04

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 42.87  E-value: 1.55e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL 71
Cdd:cd15222    4 SIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDL 47
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
28-303 1.60e-04

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 42.91  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVAL 107
Cdd:cd15211    3 STVYSFLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGTLLVLGYRLFREGLLFLGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTMLKMKLHNNGktcrVFMLISTVWFIA-----AILGGLPVMGW--------NCIDSINNCSTVL 174
Cdd:cd15211   83 TVSLLSHSLIALNRYVLITKLPAVYQA----LYQKRNTEWMIAlswalALGLLLPWLTSfryptkscHDSADGSFAVVSV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAYILFCTTVFSVILMaIVILYARIYALVRTRSRK---LVFRKVANGRGSNKSSEKSMALlkTVIIVLSCFIACWA 251
Cdd:cd15211  159 LSSRYPALLLAFTVLGQTAL-VLHCYFGIFRRVQISVKRvsvLNFQIVNNLPYSRPRKDKRLGL--YVLLVCCVFLLTTE 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 982742395 252 PLFILLL------LDVACQTltcsilykAEWFLALAVlnSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15211  236 PLVWVSLaglfvpVPVALQT--------ASWLLFCTL--FVLNPFLYTWKNEEFRRSF 283
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
39-303 1.73e-04

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 42.84  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLlaGVVYTANIL----------LSGANTYKLtpTQWFFregsmFVALA 108
Cdd:cd14988   15 LVENVLVIWVNWHRWGSKNLVNLYILNMAIADL--GVVLTLPVWmlevmldytwLWGSFLCKF--THYFY-----FANMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVFSLLAIAIERHLTMLKMKLHNNGKTCRV-FMLISTVWFIAAILGGLPVMGWNCIDSIN-NCSTVLPLY-HKAYIL-- 183
Cdd:cd14988   86 SSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIrRALCAGIWVLSAIIPLPEVVHMQLLDGVEpMCLFLAPFEtYDEWALav 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 184 -FCTTVFSVILMAIVILYARIYALVRTRsrklvfrkvangRGSNKSSEKSMALLKTVIIVlscFIACWAPLFI---LLLL 259
Cdd:cd14988  166 sLLTLIIGFLIPFSIIAVFNVLTARYIR------------TAGRPESRRHCLLIYAYILV---FVVCWLPYHVtllLLTL 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 982742395 260 DVACQTLTCSILYKAEWFL----ALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14988  231 HGSHISLHCNLVHFLYFFYdvidCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
29-303 1.88e-04

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 42.85  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL--LAGVVYTANILLSGANTYKLTPTQWFFREGSmfVA 106
Cdd:cd15094    5 VLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADEcfLIGLPFLIVTMILKYWPFGAAMCKIYMVLTS--IN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTMLKMKLHNNGKTCRV-FMLISTVWFIAAILGgLPVMGW--NCIDSINN-CSTVLPLYH---- 178
Cdd:cd15094   83 QFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIaKVVCATTWSISFLVM-LPIILYasTVPDSGRYsCTIVWPDSSavng 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 -KAYILFCTTV-FSVILMAIVILYAriyalvrtrsrkLVFRKVANGRGSNKSSEKSMA---LLKTVIIVLSCFIACWAPL 253
Cdd:cd15094  162 qKAFTLYTFLLgFAIPLLLISVFYT------------LVILRLRTVGPKNKSKEKRRShrkVTRLVLTVISVYIICWLPY 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982742395 254 FILLLLDVACQTLTCSILYKAEWFLALAVL---NSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15094  230 WAFQVHLIFLPPGTDMPKWEILMFLLLTVLsyaNSMVNPLLYAFLSENFRKSF 282
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
29-302 1.88e-04

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 42.76  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvYTANILLSGAntYKLTPTQWFFREGS------ 102
Cdd:cd15160    5 VVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLL----YILTLPLWID--YTANHHNWTFGPLSckvvgf 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 -MFVALAASVFSLLAIAIERHLTM---LKMKLHNNGKTCRvfMLISTVWFIAAILGGLPVMGWNCIDSINN---CSTVLP 175
Cdd:cd15160   79 fFYTNIYASIGFLCCIAVDRYLAVvhpLRFRGLRTRRFAL--KVSASIWVLELGTHSVFLGHDELFRDEPNhtlCYEKYP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 176 L--YHKAYILFCTTV-FSVILMAIVILYARIYALVRtRSRKLvfrkvangrgSNKSSEKSMALLKTVIIVlscFIACWAP 252
Cdd:cd15160  157 MegWQASYNYARFLVgFLIPLSLILFFYRRVLRAVR-QSPSL----------EREEKRKIIGLLLSIVVI---FLLCFLP 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 982742395 253 LFILLLLDVA---CQTLTCSI---LYKA-EWFLALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15160  223 YHVVLLVRSVielVQNGLCGFekrVFTAyQISLCLTSLNCVADPILYIFVTEDVRQD 279
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
42-255 1.93e-04

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 42.88  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  42 NVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVytaniLLSGANTYKLTpTQWFFRE-----GSMF--VALAASVFSL 114
Cdd:cd15395   18 NLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIM-----CLPFTFVYTLM-DHWVFGEamcklNSMVqcISITVSIFSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 115 LAIAIERHLTMLKMK--LHNNGKTCrvfMLISTVWfIAAILGGLPVMGWNCI--DSINNCSTVLPLYHKAYI-------- 182
Cdd:cd15395   92 VLIAIERHQLIINPRgwRPNNRHAY---VGIAVIW-VLAVLTSLPFLIFQVLtdEPFKNVNVSLDAYKGKYVcldqfpsd 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 183 ---LFCTTVFSVI-----LMAIVILYARIYALVRTRSrKLVFRKVANGRGSNKSSEKSMALLKTVIivlsCFIACWAPLF 254
Cdd:cd15395  168 tirLSYTTCLLVLqyfgpLCFIFICYLKIYIRLKRRN-NMMDKMRDNKYRSSETKRINIMLISIVV----AFAVCWLPLN 242

                 .
gi 982742395 255 I 255
Cdd:cd15395  243 I 243
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
29-294 2.54e-04

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 42.17  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTP-----TQWFFregsM 103
Cdd:cd15938    5 ALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISyeaciAQLFF----L 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVALAASVFSLLAIAIERHLTMLKmKLHNNGKTCR--VFMLISTVW---FIAAILGG-----LPVMGWNCIDsiNNCSTV 173
Cdd:cd15938   81 HFVGAAEMFLLTVMAYDRYVAICK-PLHYTTIMSRrlCWVLVAASWaggFLHSIVQTlltiqLPFCGPNQVN--NFFCDV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 174 LPLYHkayiLFCTTVFSVILMAI----VILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIac 249
Cdd:cd15938  158 PPVIK----LACTDTCVTELLMVsnsgLISTVCFVVLVTSYTTILVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFI-- 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 982742395 250 WAPLFILLLLDVacqtlTCSILYKaewflalaVLNSAMNPLIYTL 294
Cdd:cd15938  232 YARPFSTFPVDK-----HVSVLYN--------VITPMLNPLIYTL 263
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
28-303 2.99e-04

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 42.00  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIllsganTYKLTPTQWFFRE------G 101
Cdd:cd15161    4 ALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRL------VYHLSGNHWPFGEvpcrlaG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMF-VALAASVFSLLAIAIERHLTM-LKMKLHNNGKTCRVFMLISTVWFIAAIlGGLPVMGWNCIDSINNCSTVLPLY-- 177
Cdd:cd15161   78 FLFyLNMYASLYFLACISVDRFLAIvHPVKSMKIRKPLYAHVVCGFLWVIVTV-AMAPLLVSPQTVEVNNTTVCLQLYre 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 ---HKAYILFcTTVFSVILMAIVILYAriyalvrtrsrkLVFRKVANG-RGSNKSSEKSMallKTVIIVLSCFIACWAPL 253
Cdd:cd15161  157 kasRGALVSL-AVAFTIPFVTTVTCYL------------LIIRSLRTGkREEKPLKDKAI---KMIILVLTIFLICFVPY 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 982742395 254 FI---LLLLDVACQTLTCS---ILYKAEWFL-ALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15161  221 HIsryIYILSHNGAGASCSsrrGLALANRITsCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
32-310 3.08e-04

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 42.16  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  32 IIVCCFIIleNVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMfVALAASV 111
Cdd:cd15084   20 VVALASFV--NGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFM-VSLTGIV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 112 --FSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNC---------------IDSINNCSTVL 174
Cdd:cd15084   97 glWSLAILAFERYLVICKPMGDFRFQQRHAVSGCAFTWGWSLLWTSPPLFGWSSyvpeglrtscgpnwyTGGTNNNSYIL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYhkayilfcTTVFSVILMAIVILYARIYalvrtrsrkLVFRKVANGRGSNKSSEKS-MALLKTVIIVLSCFIACWAPL 253
Cdd:cd15084  177 ALF--------VTCFALPLSTIIFSYSNLL---------LTLRAVAAQQKESETTQRAeKEVTRMVIAMVMAFLICWLPY 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982742395 254 FILLLL-----DVACQTLTCSIlykAEWFLALAvlnSAMNPLIYTLTSNEMRRAFIKMLNCG 310
Cdd:cd15084  240 ATFAMVvatnkDVVIQPTLASL---PSYFSKTA---TVYNPIIYVFMNKQFRSCLLELLCCG 295
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
30-299 3.10e-04

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 41.99  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagVVYTANILLsganTYKLTPTQWFFreGSMF----- 104
Cdd:cd15967    6 VYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLL--YLLTLPFLV----VYYLKGRKWIF--GQVFckitr 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 ----VALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWfIAAILGGLPVM--------GWNCIDSINNCS 171
Cdd:cd15967   78 fcfnLNLYGSIGFLTCISVYRYLAIVHpMRVMGRITTTHSVVISALVW-LLVVIQSLPDLffsktnsnGTKCFDTTFNDY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TvlPLYHKAYILFCTTVFSVILMAIVILYARIyALVRTRSRKLvfRKVANGRgsnksseksmaLLKTVIIVLSCFIACWA 251
Cdd:cd15967  157 L--ESYLTYSLGWTVTGFVIPLLIILGCYGHV-VVVLCRNNNV--DKGLKQR-----------CLKLVIILIVLFSVCYI 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982742395 252 PLFILLLLDVACQTL----TCSilykaEWFLA----------LAVLNSAMNPLIYTLTSNEM 299
Cdd:cd15967  221 PYHVFRNLNLLSRILqkqgSCT-----QWFRGiyiahqvsrgLVCLNSALNPLVYLMGSEDI 277
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
28-303 3.31e-04

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 41.83  E-value: 3.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvytanILLSGA---NTYKLTPTQWFFREGSMF 104
Cdd:cd15123    4 YVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLL--------LLLTCVpvdATRYIADTWLFGRIGCKL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VA------LAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGgLPVMGWNCIDSINN-------- 169
Cdd:cd15123   76 LSfiqltsVGVSVFTLTVLSADRYRAIVKpLELQTSDAVLKTCCKAGCVWIVSMLFA-IPEAVFSDLYSFRDpeknttfe 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 170 CSTVLPLYHK----AYILFCTTVFSVILMAIVILYariYALVRTRSRKLVFRKVANGRG-SNKSSEKSMALLKTVIIVLS 244
Cdd:cd15123  155 ACAPYPVSEKilqeIHSLLCFLVFYIIPLSIISVY---YFLIARTLYKSTFNMPAEEHShARKQIESRKRVAKTVLVLVA 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 982742395 245 CFIACWAPLFILLL---------LDVACQTLTCSILYKaewflALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15123  232 LFAFCWLPNHILYLyrsftyhtsVDSSAFHLIATIFSR-----VLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
30-303 3.68e-04

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 41.86  E-value: 3.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVV--------YTANILLSGANTYKLTPTqwffreg 101
Cdd:cd15125    6 LYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcvpvdasrYFYEEWMFGTVGCKLIPV------- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMFVALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGgLPVMGWNCIDSINN----------- 169
Cdd:cd15125   79 IQLTSVGVSVFTLTALSADRYKAIVNpMDIQTSSAVLRTCLKAIAIWVVSVLLA-VPEAVFSEVAHIMPddnttftacip 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 170 ---CSTVLPLYHKAYILFcttVFSVILMAIVILYarIYALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCF 246
Cdd:cd15125  158 ypqTDEMHPKIHSVLIFL---VYFLIPLAIISIY--YYHIAKTLIKSAHNIPGEYSEHSKRQMETRKRLAKIVLVFVGLF 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 247 IACWAPLFILLL--------LDVACQTLTCSILYKaewflALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15125  233 AFCWFPNHVLYMyrsfnyneIDSSLGHMIVTLVAR-----VLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
29-294 3.73e-04

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 41.81  E-value: 3.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANI---LLSGANT--YKLTPTQWFFregSM 103
Cdd:cd15226    5 VFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMicdLLREHKTisFGGCMAQIFF---LH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVAlAASVFSLLAIAIERHLTMLKmKLHN----NGKTCRVFMLIStvWFIA--------AILGGLPVMGWNCIDSInNCS 171
Cdd:cd15226   82 FFG-GSEMVLLIAMAFDRYVAICK-PLHYltimSPRMCILLVVAS--WIIGfihslsqlAFVVNLPFCGPNVVDSF-FCD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 tvLPLYHKayiLFCTTVFSVILM--------------AIVILYARIYALVRTRsrklvfrkvangrgSNKSSEKSMALLK 237
Cdd:cd15226  157 --LPLVIK---LACTDTYVLELMvvansglislvcflLLLISYIVILVTVRKH--------------SSGGSSKALSTCS 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982742395 238 TVIIVLS-----C-FIACWapLFILLLLDVacqtlTCSILYkaewflalAVLNSAMNPLIYTL 294
Cdd:cd15226  218 AHITVVVlffgpCiFIYVW--PFSTFPVDK-----FLAVFY--------TVITPLLNPIIYTL 265
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
28-303 3.80e-04

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 41.65  E-value: 3.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILlsgantyKLTPTQWFFREGSMFVAL 107
Cdd:cd15087    4 PVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIA-------EHLLQQWPFGELLCKLIL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 A-------ASVFSLLAIAIERHLTMLKM--KLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDS----INNCSTVL 174
Cdd:cd15087   77 SidhynifSSIYFLTVMSVDRYLVVLATvrSRRMPYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYSnelgRKSCVLSF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAYilFCTTVFSVILMAIVILYARIYALVRTRSRKL-VFRKVANGRGSNKSSEKSMALlktVIIVLSCFIACWAPL 253
Cdd:cd15087  157 PSPESLW--FKASRIYTLVLGFAIPVSTICILYTMMLYKLrNMRLNSNAKALDKAKKKVTLM---VLVVLAVCLFCWTPF 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 254 ----FILLLLDVACQTLTCSILYkaeWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15087  232 hlstVVALTTDLPQTPLVIGISY---FITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
29-71 4.48e-04

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 41.62  E-value: 4.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL 71
Cdd:cd15429    5 VLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDI 47
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
29-294 4.51e-04

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 41.55  E-value: 4.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIL---LSGANT--YKLTPTQWFFregSM 103
Cdd:cd15936    5 LVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLsdlLSQTKTisFNGCMAQMFF---FH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVAlAASVFSLLAIAIERHLTMLKmKLHN----NGKTCRVfmLISTVWFIA--------AILGGLPVMGWNCIDsinNCS 171
Cdd:cd15936   82 FTG-GAEVFLLSVMAYDRYIAIHK-PLHYltimNQGVCTG--LVAGSWLGGfahsivqvALLLQLPFCGPNVLD---NFY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 172 TVLPLYHKayiLFCTTVFSV-ILMA-----------IVILYARIYALVRTRSRklvfrkVANGRGSNKSSEKSMALLKTV 239
Cdd:cd15936  155 CDVPQVIK---LACTDTFLLeLLMVsnsglvtllifFILLISYTVILVKIRTH------VTEGKRKALSTCASQITVVTL 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 240 IIVLSCFIacWAPLFILLLLDVAcqtltCSILYkaewflalAVLNSAMNPLIYTL 294
Cdd:cd15936  226 IFVPCIYI--YARPFQTFPMDKA-----VSVLY--------TVITPMLNPMIYTL 265
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
28-301 4.54e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 41.69  E-value: 4.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVvytanillSGANTYKLTPTQWFF---REGSMF 104
Cdd:cd15075    4 SIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTV--------FGGLLSVVTNAVGYFnlgRVGCVL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 105 VALAASVFSLLA------IAIERHLTMLKmKLHNNGKTCRVFML-ISTVWFIAAILGGLPVMGW----------NCIDSI 167
Cdd:cd15075   76 EGFAVAFFGIAAlctvavIAVDRLFVVCK-PLGTLTFQTRHALAgIASSWLWSLIWNTPPLFGWgsyqlegvmtSCAPDW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 168 NNCSTVLPLYHKAYILFCttvFSVILMAIVILYARIYALVRTrsrklVFRKVANGRGSNKSSEKSMALLktVIIVLSCFI 247
Cdd:cd15075  155 YSRDPVNVSYILCYFSFC---FAIPFAIILVSYGYLLWTLRQ-----VAKLGVAEGGSTAKAEVQVARM--VVVMVMAFL 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 248 ACWAPLFILLLLDVACQTLTCSILYkAEWFLALAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15075  225 LCWLPYAAFALTVVSKPDVYINPLI-ATVPMYLAKSSTVYNPIIYIFMNKQFRD 277
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
28-121 4.68e-04

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 41.52  E-value: 4.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIL---LSGANT--YKLTPTQWFFreGS 102
Cdd:cd15419    4 FLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALanfLSESKTisYNGCAAQFFF--FS 81
                         90
                 ....*....|....*....
gi 982742395 103 MFVALAAsvFSLLAIAIER 121
Cdd:cd15419   82 LFGTTEG--FLLAAMAYDR 98
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
29-71 4.75e-04

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 41.49  E-value: 4.75e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL 71
Cdd:cd15237    5 ILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDI 47
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
29-122 4.84e-04

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 41.43  E-value: 4.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIL---LSGANTYKLTP--TQWFFregsM 103
Cdd:cd15229    5 LVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLenlLSERKTISVEGciAQIFF----F 80
                         90
                 ....*....|....*....
gi 982742395 104 FVALAASVFSLLAIAIERH 122
Cdd:cd15229   81 FFFAGTEAFLLSAMAYDRY 99
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
28-303 4.95e-04

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 41.33  E-value: 4.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHK--PMYYFIGNLALSDLLAGVVytaniLLSGANTYKLTpTQWFF-----RE 100
Cdd:cd14976    4 SVVYMVVFTVGLLGNLLVLYLLKSNKKLRQqsESNKFVFNLALTDLIFVLT-----LPFWAVEYALD-FVWPFgtamcKV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 GSMFVALA--ASVFSLLAIAIERHLTmLKMKLHNNGKTCRVFMLISTVW-FIAAILGGLP--VMGWNCIDSINNCSTVLP 175
Cdd:cd14976   78 VRYVTKLNmySSIFFLTALSVTRYIA-VARALKHGWIRKAFGAFATTIAiWAAAALAAIPeaIFSTDTWSSVNHTLCLLR 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 176 LYHKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSnkSSEKSMALLKTVIIVLSCFIACWAPLFI 255
Cdd:cd14976  157 FPKNSSVTRWYNWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGG--SKRRKSRVTKSVFIVVLSFFICWLPNQA 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 982742395 256 LLLLDVACQTLtcSILYKAEWFLA----------LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd14976  235 LSLWSALIKFD--DVPFSDAFFAFqtyafpvaicLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
29-98 5.60e-04

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 41.26  E-value: 5.60e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILL-----SGANTYKLTPTQWFF 98
Cdd:cd15228    5 VLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAylwgqSRVISLGGCMSQVFF 79
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
29-301 6.02e-04

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 41.28  E-value: 6.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagVVYTANILLsganTYKLTPTQWFFREGS------ 102
Cdd:cd15373    5 VSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTL--YVLSLPLLV----YYYADENDWPFSEALckivrf 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 -MFVALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGlPVMGWNCI----DSINNCSTVLPL 176
Cdd:cd15373   79 lFYTNLYCSILFLLCISVHRFLGVCYpVRSLRWLKVRYARIVSVVVWVIVLACQS-PVLYFVTTsdkgGNITCHDTSSPE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 YHKAYILFcTTVFSVILMA---IVILYAriYALVrtrSRKLVfRKVANGRGSNKSSEKSmalLKTVIIVLSCFIACWAPL 253
Cdd:cd15373  158 LFDQFVVY-SSVMLVLLFCvpfVVILVC--YALM---VRKLL-KPSAGTSTNSRSKKKS---VKMIIIVLAVFILCFLPF 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 254 FI-------LLLLDVACQTL-TCSILYKAEWFLALAvlNSAMNPLIYTLTSNEMRR 301
Cdd:cd15373  228 HVtrtlyysFRSMDLSCGTLnAINLAYKVTRPLASA--NSCLDPILYFLAGQSFRS 281
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
29-303 6.13e-04

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 41.27  E-value: 6.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL--LAGVVYTAnillsganTYKLTPTQWFFRE------ 100
Cdd:cd15191    5 VLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLlfLATLPLWA--------TYYSYGYNWLFGSvmckic 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 GSMF-VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWfIAAILGGLPVMGWNCIDSINN-----CSTVL 174
Cdd:cd15191   77 GSLLtLNLFASIFFITCMSVDRYLAVVYPLRSQRRRSWQARLVCLLVW-VLACLSSLPTFYFRDTYYIEElgvnaCIMAF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAYILFCTTVFSVIL--MAIVILYARIYALVRtrsrklvfRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAP 252
Cdd:cd15191  156 PNEKYAQWSAGLALMKNTLgfLIPLIVIATCYFGIG--------RHLLKTKGFGKNKQRRDKVLKMVAAVVLAFLICWFP 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 982742395 253 LFILLLLDV--------ACQTLTcSILYKAEWFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15191  228 FHVLTFLDAlarmgvinNCWVIT-VIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
39-123 6.97e-04

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 40.86  E-value: 6.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILL-----SGANTYKLTPTQWFFREGsmFVALAASVfs 113
Cdd:cd15950   15 LLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSifwlgSAEISFEACFTQMFFVHS--FTAVESGV-- 90
                         90
                 ....*....|
gi 982742395 114 LLAIAIERHL 123
Cdd:cd15950   91 LLAMAFDRYV 100
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
29-117 7.14e-04

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 40.88  E-value: 7.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTP-----TQWFFregsm 103
Cdd:cd15945   18 LVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPfygcaLQMFF----- 92
                         90
                 ....*....|....
gi 982742395 104 FVALAASVFSLLAI 117
Cdd:cd15945   93 FAAFADAECLLLAV 106
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
62-303 7.48e-04

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 41.04  E-value: 7.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  62 FIGNLALSDLLAGVV--------YTANILLSGANTYKLTPtqwFFREGSMFValaaSVFSLLAIAIERHLTMLK-MKLHN 132
Cdd:cd15124   38 FISSLALGDLLLLVTcapvdasrYLADEWLFGRVGCKLIP---FIQLTSVGV----SVFTLTALSADRYKAIVRpMDIQA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 133 NGKTCRVFMLISTVWFIAAILGgLPVMGWNCIDSINNCSTVLP------------LYHKAYILFCTTVFSVILMAIVILY 200
Cdd:cd15124  111 SNALMKICLKAALIWILSMLLA-IPEAVFSDLHPFYDKSTNKTfvscapyphsneLHPKIHSMASFLIFYVIPLSIISVY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 201 arIYALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLL--------LDVACQTLTCSILY 272
Cdd:cd15124  190 --YYFIAKNLIRSAYNLPVEGNVHVRRQIESRKRLAKTVLVFVGLFAFCWLPNHIIYLyrsyhyseVDTSMLHFVSSICA 267
                        250       260       270
                 ....*....|....*....|....*....|.
gi 982742395 273 KaewflALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15124  268 R-----ILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
28-303 7.53e-04

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 40.68  E-value: 7.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVAL 107
Cdd:cd15155    4 GAVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 AASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKAyilFCTT 187
Cdd:cd15155   84 YGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKS---IWKT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 188 VFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLD--VACQT 265
Cdd:cd15155  161 YLSKITIFIEVVGFIIPLLLNLTCSSLVLRTLRKPATLSQIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYalVRSQA 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 982742395 266 LT-CSILYKAEWF----LALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15155  241 IAnCGVERFARTMypitLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
29-300 8.01e-04

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 40.89  E-value: 8.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSD--LLAGVVYTANILLSGANtykltptqWFFREGSMFVA 106
Cdd:cd14991    5 PLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADflLLICLPFRIDYYLRGEH--------WIFGEAWCRVN 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 L-------AASVFSLLAIAIERHLTMLKMKLH-NNGKTCRVFMLISTVWFIAaILGGLPVMGWNCIDSINNCSTVLPLYH 178
Cdd:cd14991   77 LfmlsvnrSASIAFLTAVALDRYFKVVHPHHRvNRMSVKAAAGVAGLLWALV-LLLTLPLLLSTLLTVNSNKSSCHSFSS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 KA---------YILFCTTVFsVILMAIVILYARIYALVRTRSRKlvfrkvangrGSNKSSEKSMALLKTVIIV-----LS 244
Cdd:cd14991  156 YTkpslsirwhNALFLLEFF-LPLGLIVFCSVRIACNLRIRQSL----------GKQARVQRAIRLVFLVVIVfvlcfLP 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982742395 245 CFIACWAPLFILLLLDVACQTLTCSILYKAewfLALAVLNSAMNPLIYTLTSNEMR 300
Cdd:cd14991  225 SIIAGLLALVFKNLGSCRCLNSVAQLFHIS---LAFTYLNSALDPVIYCFSSPWFR 277
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
28-303 8.34e-04

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 40.61  E-value: 8.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIvccFII--LENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvYTANIL-------LSGANTYKLTP--TQW 96
Cdd:cd15421    5 SLILLI---FLValTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLM----LISTTVpkmatnfLSGRKSISFVGcgTQI 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  97 FFregsmFVALAASVFSLLA-IAIERHLTM---LKMKLHNNGKTCRvfMLISTVWFIAAILG--------GLPVMGWNCI 164
Cdd:cd15421   78 FF-----FLTLGGAECLLLAlMAYDRYVAIchpLRYPVLMSPRVCL--LMAAGSWLGGSLNSlihtvytmHFPYCGSREI 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 165 DSInNC--STVLPL-------YHKAyILFCTTVFSVI-LMAIVILYARIYALV-RTRSRKlvfrkvanGRgsnkssEKSM 233
Cdd:cd15421  151 HHF-FCevPALLKLscadtsaYETV-VYVSGVLFLLIpFSLILASYALILLTVlRMRSAE--------GR------KKAL 214
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982742395 234 ALLKTVIIVLSCFIAcwAPLFILLLLDVAC---QTLTCSILYkaewflalAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15421  215 ATCSSHLTVVSLYYG--PAIFTYMRPGSYHspeQDKVVSVFY--------TILTPMLNPLIYSLRNKEVLGAL 277
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
42-300 8.39e-04

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 40.58  E-value: 8.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  42 NVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTY-KLTPTQWFFREGSMFVALAASVFSLLAIAIE 120
Cdd:cd15077   18 NVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYfVLGPLACKIEGFTATLGGMVSLWSLAVVAFE 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 121 RHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWN-CIDSINNCSTVLPLY-------HKAYILFC-TTVFSV 191
Cdd:cd15077   98 RFLVICKPLGNFTFRGTHAIIGCIATWVFGLAASLPPLFGWSrYIPEGLQCSCGPDWYttnnkwnNESYVMFLfCFCFGV 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 192 ILMAIVILYARIYalvrtrsrkLVFRKVANGRGSNKSSEKS-MALLKTVIIVLSCFIACWAPLFILLLLDVAcqtltcsi 270
Cdd:cd15077  178 PLSIIVFSYGRLL---------LTLRAVAKQQEQSASTQKAeREVTKMVVVMVLGFLVCWLPYASFALWVVT-------- 240
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 982742395 271 lYKAEWF-LALAVLNSAM-------NPLIYTLTSNEMR 300
Cdd:cd15077  241 -NRGEPFdLRLASIPSVFskastvyNPVIYVFMNKQFR 277
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
62-302 9.12e-04

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 40.61  E-value: 9.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  62 FIGNLALSDLLagVVYTANILLSGANTYKLTPTQWFFREGSMF---VALAASVFSLLAIAIERHLTML------KMKLHN 132
Cdd:cd15194   38 FISNLAASDFI--FLVTLPLWVDKEVVLGPWRSGSFLCKGSSYiisVNMYCSVFLLTCMSLDRYLAIVlplvsrKFRTKH 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 133 NGKTCrvfmlISTVWFIAAILGgLPVMGWNCIDSINN---CSTVLPLYHKAYILFCTTVFS--VILMAIVILYARIyalv 207
Cdd:cd15194  116 NAKVC-----CTCVWMLSCLLG-LPTLLSRELKKYEEkeyCNEDAGTPSKVIFSLVSLIVAffLPLLSILTCYCTI---- 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 208 rtrSRKLVfrkvANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDVA--------CQTLTCSILyKAEWFLA 279
Cdd:cd15194  186 ---IWKLC----HHYQKSGKHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKALAIAsglqvevtCLPYTLAQL-GMEVSAP 257
                        250       260
                 ....*....|....*....|...
gi 982742395 280 LAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15194  258 LAFANSCANPFIYYFFDRYIRRA 280
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
26-252 1.04e-03

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 40.59  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  26 ADSVVFIIVCCFIIleNVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGsMFV 105
Cdd:cd15080    4 AAYMFLLILLGFPI--NFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEG-FFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 106 ALAASV--FSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWN-CIDSINNCS------TVLP- 175
Cdd:cd15080   81 TLGGEIalWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSrYIPEGMQCScgidyyTLKPe 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 982742395 176 LYHKAYILFCTTV-FSVILMAIVILYARIYALVRtrsrklvfRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAP 252
Cdd:cd15080  161 VNNESFVIYMFVVhFTIPLIVIFFCYGRLVCTVK--------EAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVP 230
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
28-303 1.17e-03

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 40.18  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagVVYTANILLsganTYKLTPTQWFFRE------- 100
Cdd:cd15921    4 PTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLL--LVCTLPLRL----TYYVLNSHWPFGDiacriil 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 GSMFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVM--GWNCIDSINNCSTVLPLYH 178
Cdd:cd15921   78 YVLYVNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLfaKSKQHDEGSTRCLELAHDA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 KAYILFCTTV-----FSVILMAIVILYARIYalvrtrsrkLVFRKVANGRGSNKSSEKSMalLKTVIIVLSCFIACWAPL 253
Cdd:cd15921  158 VDKLLLINYVtlpvgFVVPFMTVIFCYIFII---------KNLLKPSPALGRTRPSRRKA--CALIIISLGIFLVCFLPY 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 982742395 254 FI-----LLLLDVACQTLTCSI-LYKAEWF-LALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15921  227 HIvrtihLITERQIKESCGYILrVRKAAVItLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
28-71 1.21e-03

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 40.33  E-value: 1.21e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL 71
Cdd:cd15231    4 FLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDI 47
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
29-133 1.23e-03

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 40.10  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANI---LLSGANT--YKLTPTQWFFregsm 103
Cdd:cd15407    5 IIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVmagLLTGDKVisYNACAAQMFF----- 79
                         90       100       110
                 ....*....|....*....|....*....|.
gi 982742395 104 FVALAASVFSLLA-IAIERHLTMLKmKLHNN 133
Cdd:cd15407   80 FVVFATVENFLLAsMAYDRHAAVCK-PLHYT 109
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
28-292 1.25e-03

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 40.03  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIW-RTKKFHKPMYYFIgNLALSDLLagvvYTanILLSGANTYKLTPTQWFFREGS---- 102
Cdd:cd15159    4 PLFYSLILVFGLLGNTLALHVICqKRKKINSTTLYLI-NLAVSDIL----FT--LALPGRIAYYALGFDWPFGDWLcrlt 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 ---MFVALAASVFSLLAIAIERHLTML-KMKLHNNGKTCRVFMLISTVWFIAAIL--------------GGLPVMGWNCI 164
Cdd:cd15159   77 allFYINTYAGVNFMTCLSVDRYIAVVhPLRRHRLRKVKVVRYICVFVWVLVFLQtlpllfmpmtkemgGRITCMEYPNF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 165 DSINNCSTVLplyhkayILFCTTVFSVILMAIVILYARIyalvrtrSRKLvFRKVANGRGSNKSSEKSMALLkTVIIVLS 244
Cdd:cd15159  157 EKIKRLPLIL-------LGACVIGFGVPVGIILFCYSQI-------TLKL-CRTAKENPLTEKSGHHKKACN-VILLVLL 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 982742395 245 CFIACWAPLFILLLLDVACQTL---TCSILYKAEWFLALAV----LNSAMNPLIY 292
Cdd:cd15159  221 VFVVCFSPYHLNIIQFMIRKLLyqpSCSELKAFKISLQITVclmnLNCCLDPFIY 275
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
29-71 1.29e-03

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 39.89  E-value: 1.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL 71
Cdd:cd15939    5 VVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDI 47
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
30-158 1.49e-03

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 39.75  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  30 VFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAgVVYTANILLSGantykLTPTQWFFREGSMF----- 104
Cdd:cd15398    6 LYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILV-VLFCSPFTLTC-----VLLDQWIFGEVMCHivpfl 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 982742395 105 --VALAASVFSLLAIAIERHlTMLKMKLHNNGKTCRVFMLISTVWFIA-AILGGLPV 158
Cdd:cd15398   80 qcVSVMVSTLMLMSIAIVRY-HMIKHPLSNHLTANHGYFLLGTVWTLGfTICSPLPV 135
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
28-303 1.55e-03

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 39.72  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVccfiILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLlagvvyTANILLSGANTYKLTPTQWFFRE------- 100
Cdd:cd15192    8 SIIFVVG----IFGNSLVVIVIYCYMKLKTVANIFLLNLALADL------CFLITLPLWAAYTAMEYHWPFGNflckias 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 101 GSMFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCS-TVLPLYHK 179
Cdd:cd15192   78 ALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENTNiTVCAFHYP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 AYILfcTTVFSVILMAIVILYARIYALVRTrSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLL 259
Cdd:cd15192  158 SQNS--TLLVGLGLMKNLLGFLIPFLIILT-CYTLIGKALKKAYEIQRNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTFL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982742395 260 DVACQTLTCSILYKAE-------WFLALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15192  235 DVLIQLKVIQDCHIADivdtampFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
29-71 2.02e-03

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 39.60  E-value: 2.02e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL 71
Cdd:cd15915    5 VLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDI 47
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
29-166 2.06e-03

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 39.35  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIL---LSGANTYKLTP--TQWFFregsM 103
Cdd:cd15940    5 MLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLsdlLSEEKTISFNGcvTQLFF----L 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982742395 104 FVALAASVFSLLAIAIERHLTMLK-MKLHN--NGKTCrvFMLISTVWFIAAILG--------GLPVMGWNCIDS 166
Cdd:cd15940   81 HLFACTEIFLLTIMAYDRYVAICNpLHYPTvmNHKVC--LWLVAALWLGGTVHSlaqtfltiRLPYCGPNEIDS 152
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
28-301 2.57e-03

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 39.27  E-value: 2.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvytANILLSGANTYKLtpTQWFFRE------G 101
Cdd:cd15182    4 PVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLL------FTFTLPFWASYHS--SGWIFGEilckavT 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMF-VALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLP------VMGWNCIDSInnCSTVL 174
Cdd:cd15182   76 SIFyIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPelilstVMKSDEDGSL--CEYSS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 175 PLYHKAYILFCTTVFSVILMAIVILYARIY-ALVRTRSRKlvfrkvangrgsnksseKSMALLKTVIIVLSCFIaCWAP- 252
Cdd:cd15182  154 IKWKLGYYYQQNLFFLIPLGIIVYCYVRILqTLMRTRTMR-----------------KHRTVKLIFVIVLVFFL-SWAPy 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 253 ---LFILLLLDVACQTLTCS--ILYKAEWFLALAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15182  216 nivIFLRSLKDLTIPICECSkqLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRN 269
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
28-292 2.73e-03

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 39.05  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSgANTYKLTPTQWFFREGSMFVAL 107
Cdd:cd15404    4 SAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVT-IITTRWIFGDAFCRVSAMFFWL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 108 --AASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLIS--TVWFIAAILG------GLPVMGWNCIDSInncsTVLPLY 177
Cdd:cd15404   83 fvMEGVAILLIISIDRFLIIVQKQDKLNPYRAKVLIAVSwaVSFCVAFPLAvgspdlQIPSRAPQCVFGY----TTNPGY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 178 HKAYILFCTTVFSVILMaiVILYARIYALVRTRSRKlvfrkvangrgsnksseksMALLKTVIIVLSCFIACWAPLFILL 257
Cdd:cd15404  159 QAYVILIMLIFFFIPFM--VMLYSFMGILNTVRSFK-------------------TRAFTTILILFIVFTVCWAPFTTYS 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 982742395 258 LLdvacQTLTCSILYKAE------WFLALAVLNSAMNPLIY 292
Cdd:cd15404  218 LV----ATFNSHFYHKHNffeistWLLWLCYLKSALNPLIY 254
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
42-292 2.81e-03

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 39.02  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  42 NVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLsgantYKLTPTQWFFRE-GSMFV------ALAASVFSL 114
Cdd:cd15198   18 NTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQII-----WELLGDRWMAGDvACRLLkllqasARGASANLV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 115 LAIAIERHLTMLKmklhNNGKTCRVFMLISTVWFIAAILGGLP--VMGWNCIDSINN-------CSTV---LPLYH-KAY 181
Cdd:cd15198   93 VLLALDRHQAIRA----PLGQPLRAWKLAALGWLLALLLALPQayVFRVDFPDDPASawpghtlCRGIfapLPRWHlQVY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 182 ILFCTTV-FSVILMAIVILYARIYALVRTRSRKLVFRKVA-------NGRGSNKSS---EKSMALLKTVIIVLScFIACW 250
Cdd:cd15198  169 ATYEAVVgFVAPVVILGVCYGRLLLKWWERANQAPGAKKPwkkpsksHLRATAPSAlprAKVKTLKMTLVIALL-FVGCS 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 982742395 251 APLFILLLLdVACQTLTCSILYKAEWFLALAVLNSAMNPLIY 292
Cdd:cd15198  248 LPYFIAELA-AAFGSGDWEPEKVAAALGVMAVANSATNPFVF 288
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
39-303 2.88e-03

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 38.90  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV------VYTANILLSGANTYKLTptqwffreGSMF-VALAASV 111
Cdd:cd15180   15 LLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVtlpfwaVQAVHGWIFGTGLCKLA--------GAVFkINFYCGI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 112 FSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAaILGGLPVMGW---------NCIDSINNCSTVLPLY-HKA 180
Cdd:cd15180   87 FLLACISFDRYLSIVHaVQMYSRKKPMLVHLSCLIVWLFC-LLLSIPDFIFleatkdprqNKTECVHNFPQSDTYWwLAL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 181 YILFCTTVFSVILMAIVILYARIYALVRTRSRKlvFRKvangrgsnkssEKSMALLKTVIIVlscFIACWAPLFILLLLD 260
Cdd:cd15180  166 RLLYHIVGFLLPLAVMVYCYTSILLRLLRSSQG--FQK-----------QRAIRVIVAVVVV---FFLCWTPYNIALLVD 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982742395 261 VACQTLTCSILYKAEWFL--------ALAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd15180  230 TLIDLSVLDRNCGTESRLdialsvtsSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
29-117 2.89e-03

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 38.88  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIL---LSGANTYKLT--PTQWFFregsm 103
Cdd:cd15943   19 AVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLvnfLAENKTISFTgcAAQMYF----- 93
                         90
                 ....*....|....
gi 982742395 104 FVALAASVFSLLAI 117
Cdd:cd15943   94 FVAFATTECFLLAV 107
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-302 3.32e-03

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 39.01  E-value: 3.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFII--LENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvytanILLS-GANTYKLTPTQ-WFFREG--- 101
Cdd:cd15132    3 VTIVCLILFVVgvTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLL--------ILLClPFDLYRLWKSRpWIFGEFlcr 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 -SMFVA---LAASVFSLLAIAIERHLTM---LKMKLHNNGKtcRVFMLISTVWFIAAILGG--LPVMGWNCIDSINNCST 172
Cdd:cd15132   75 lYHYISegcTYATILHITALSIERYLAIcfpLRAKVLVTRR--RVKCVIAALWAFALLSAGpfLFLVGVEQDNNIHPDDF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 173 VLPLYHKAY----------ILFCTTVFSVILMAIVILYARIYALVRTRSRKLvfrKVANGRGSNKSSEKSMALLKTVIIV 242
Cdd:cd15132  153 SRECKHTPYavssgllgimIWVTTTYFFLPMLCLSFLYGFIGRKLWKSKNDL---RGPNAAARERSHRQTVRILAVVVLA 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982742395 243 lscFIACWAPLFILLLLDVacQTLTCSILYKAEWF----LALAVLNSAMNPLIYTLTSNEMRRA 302
Cdd:cd15132  230 ---FIICWLPFHIGRILFA--NTEDYRTMMFSQYFnivaMQLFYLSASINPILYNLISRKYRAA 288
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
40-307 3.35e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 38.98  E-value: 3.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  40 LENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVytaniLLSGANTYKLTPTQWFF------REGSMFVALA-ASVF 112
Cdd:cd15212   16 LGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALL-----CLPFAFLTLFSRPGWLFgdrlclANGFFNACFGiVSTL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 113 SLLAIAIERHLTMLKMKLHNNGKTcRVFMLISTVWfIAAILGGLPvmgWNCIDSINNCSTVLPLYHKAYILFCTT----- 187
Cdd:cd15212   91 TMTLISFDRYYAIVRQPQGKIGRR-RALQLLAAAW-LTALGFSLP---WYLLASAPEYYEKLGFYHCLYVLHSGPsrlga 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 188 VFSVILMAIVILYARI------YALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDV 261
Cdd:cd15212  166 AYSSVLIVLCYLLPFAlmcfchYNICKTVRLSESRVRPVTTYAHLLRFYSEMRTATTVLIMIVFIICCWGPYCLLGLVAA 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 982742395 262 ACQTLTCSILYKAEWFLALAvlNSAMNPLIYTltsneMRRAFIKML 307
Cdd:cd15212  246 AGGYQFPPLMDTVAIWMAWA--NGAINPLIYA-----IRNPNISML 284
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
29-117 3.39e-03

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 38.62  E-value: 3.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagvvYTANI-------LLSGANTYKLTP--TQWFFr 99
Cdd:cd15912    5 LLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEIL----FTSVVipkmlanLLSGKKTISFAGcfAQSFF- 79
                         90
                 ....*....|....*...
gi 982742395 100 egsmFVALAASVFSLLAI 117
Cdd:cd15912   80 ----YFFLGTTEFFLLAV 93
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
29-260 3.84e-03

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 38.63  E-value: 3.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLL--AGVVYTANILLSgantykltptQWFF-------R 99
Cdd:cd15187    5 VLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLfvFSLPFQAYYLLD----------QWVFgnamckiV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 100 EGSMFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHK 179
Cdd:cd15187   75 SGAYYIGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 AYILF-CTTVFSVILMAIVILYA-RIYALVRtrsrklVFRKVANGRGSNKSseKSMALLKTVIIVLSCFiacWAPLFILL 257
Cdd:cd15187  155 QGNSWkVFTNFEVNILGLLIPFSiLIFCYHN------ILRNLRRCHNQNKT--KAIKLVFIVVIVFFLF---WTPFNVVL 223

                 ...
gi 982742395 258 LLD 260
Cdd:cd15187  224 FLD 226
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
28-72 4.35e-03

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 38.48  E-value: 4.35e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLL 72
Cdd:cd15951    4 SIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLV 48
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
104-301 4.59e-03

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 38.25  E-value: 4.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 104 FVALAASVFSLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAI--LGGLPVMGWNCIDSINNC-STVLPLYHK 179
Cdd:cd15374   81 YANLYCSILFLTCISVHRYVGICHpIRALRWVKPRHAYLICASVWLVVTVclVPNLIFVTTSRKDNITLChDTTRPEEFD 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 AYILFCTTVFSVILMAIVILYARIYALVrtrSRKLVFRKVANGRGSNKSSEKSMalLKTVIIVLSCFIACWAPLFIL--- 256
Cdd:cd15374  161 HYVHYSSAVMVLLFGIPCLVIVVCYGLM---ARRLCKPRVGSSRQQGPSSKKRS--LKTIIMVLTVFAICFVPFHITrtl 235
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 982742395 257 ----LLLDVACQTLTC-SILYKAEwfLALAVLNSAMNPLIYTLTSNEMRR 301
Cdd:cd15374  236 yyvaRLLKADCDTLNIiNVTYKVT--RPLASANSCLDPILYFLAGDKYRR 283
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
33-301 4.65e-03

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 38.21  E-value: 4.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  33 IVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV---VYTANIllsgANTYkltptQWFFRE-------GS 102
Cdd:cd15381    9 IIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCclpFWAINI----SNGF-----NWPFGEflcksvnAV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 MFVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCID-----SINNCSTVLP-L 176
Cdd:cd15381   80 IYMNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMyfpeyNITACVLDYPsE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 YHKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKLvfRKVANGRGSNKSSeksmallKTVIIVLSCFIACWAPLFIL 256
Cdd:cd15381  160 GWHVALNILLNVVGFLIPLSIITFCSTQIIQVLRNNKM--QKFKEIQTERKAT-------VLVLAVLLMFFICWLPFHIF 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982742395 257 LLLDVACQTLTCS---------ILYKAEWFLALAvlNSAMNPLIYTLTSNEMRR 301
Cdd:cd15381  231 TFLDTLHKLGLISgcrwedildIGTQIATFLAYS--NSCLNPLLYVIVGKHFRK 282
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
109-300 4.81e-03

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 38.19  E-value: 4.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 109 ASVFSLLAIAIERHLTMLKMKLHNNGKT-CRVFMLISTVWFIAAILGGlPVMGWNCIDSINNCSTVLP---LYHKAYILF 184
Cdd:cd15119   85 ASVLFLTVISLDRYISLAHPVWSHRYRTlKSALILCGIVWLSAAAISG-PALYFRDTMELSINVTICFnnfHKHDGDLIV 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 185 CTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKsseksmaLLKTVIIVLSCFIACWAPLFILLLLDVACQ 264
Cdd:cd15119  164 MRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLISSK-------FFWTISAVIVAFFVCWTPYHIFSILELSIH 236
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 982742395 265 tltcSILYKAEWFLA-------LAVLNSAMNPLIYTLTSNEMR 300
Cdd:cd15119  237 ----HSSYLHNVLRAgiplatsLAFINSCLNPILYVLIGKKFK 275
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
29-71 4.94e-03

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 38.46  E-value: 4.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL 71
Cdd:cd15420    5 GLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDI 47
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
39-300 5.15e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 38.20  E-value: 5.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKpmYYFIGNLALSDLLAGVVYTANILLSGA---NTYKLTPTQWffrEGSMFVA---LAASVF 112
Cdd:cd15220   14 LVGNTAVMVVIAKTPHLRK--FAFVCHLCVVDLLAALLLMPLGILSSSpffLGVVFGEAEC---RVYIFLSvclVSASIL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 113 SLLAIAIERHLTMLK-MKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCID-----SINNCS--TVLPLYHKAY-IL 183
Cdd:cd15220   89 TISAISVERYYYIVHpMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGgpapiAARHCSlhWSHSGHRGVFvVL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 184 FCTTVFSVILMAIVILYARIYAlvrtrsrklVFrkvangrGSNKSSeksmallKTVIIVLSCFIACWAPLFIL-LLLDVA 262
Cdd:cd15220  169 FALVCFLLPLLLILVVYCGVFK---------VF-------GGGKAA-------LTLAAIVGQFLCCWLPYFAFhLYSALA 225
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 982742395 263 CQTLTCSILYKAEWFLALAVLnsAMNPLIYTLTSNEMR 300
Cdd:cd15220  226 ASPVSGGEAEEVVTWLAYSCF--AVNPFFYGLLNRQIR 261
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
29-117 5.42e-03

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 38.26  E-value: 5.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIL---LSGANTYKLT--PTQWFFregsm 103
Cdd:cd15230    5 VLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLvnfLSEKKTISFAgcAAQFFF----- 79
                         90
                 ....*....|....
gi 982742395 104 FVALAASVFSLLAI 117
Cdd:cd15230   80 FAVFGTTECFLLAA 93
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
29-292 5.83e-03

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 38.15  E-value: 5.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLagVVYTanilLSGANTYKLTPTQWFFRE-------G 101
Cdd:cd15157    5 TVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLM--FVST----LPFRADYYLMGSHWVFGDiacrimsY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 102 SMFVALAASVFSLLAIAIERHLTML-KMKLHNNGKTCRVFMLISTVW-FIAAILGGLPVMGWNCIDSINNCSTvLPLYHK 179
Cdd:cd15157   79 SLYVNMYCSIYFLTVLSIVRFLAIVhPFKLWKVTSIKYARILCAVIWiFVMAASSPLLSKGTSKYNSQTKCLD-LHPSKI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 180 AYILFCTTV-----FSVILMAIVILYA-RIYALVRTRSRKlvfrkvANGRGSNKSSeksmalLKTVIIVLSCFIACWAPL 253
Cdd:cd15157  158 DKLLILNYIvlvvgFILPFCTLSICYIlIIKALLKPRVPQ------SKLRVSHKKA------LLTIIITLILFLLCFLPY 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 982742395 254 FIL--LLLDVACQTLTCSILYKAEWF-LALAVLNSAMNPLIY 292
Cdd:cd15157  226 HILrtVHLMQWSEGQCNLRLHKAVVItLCLAAANSCLDPLLY 267
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-303 5.83e-03

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 37.92  E-value: 5.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  28 SVVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL-LAGVVYTANILLSGANTYKLTPTQWFFREGSMFVA 106
Cdd:cd16002    4 AVAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEAsMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 107 LAASVFSLLAIAIERHLTMLKmKLHNNGKTCRVFMLISTVWFIAAILGgLPVMGWNCIDSINN---CSTVLP-----LYH 178
Cdd:cd16002   84 VFASIYSMTAIALDRYMAIIH-PLQPRLSATATKVVICVIWVLAFLLA-FPQGYYSDTEEMPGrvvCYVEWPeheerKYE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 179 KAYiLFCTTVFSVILMAIVILYARIYALVRTRSRKLvfrkvaNGRGSNKSSEKSMALLKTV---IIVLSCFIACWAPLFI 255
Cdd:cd16002  162 TVY-HVCVTVLIYFLPLLVIGCAYTVVGITLWASEI------PGDSSDRYHEQVSAKRKVVkmmIVVVCTFAICWLPYHI 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982742395 256 LLLLDVACQTLTCSILYKaEWFLA---LAVLNSAMNPLIYTLTSNEMRRAF 303
Cdd:cd16002  235 YFLLQYFHPELYEQKFIQ-QVYLAimwLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
29-301 7.03e-03

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 37.96  E-value: 7.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGV--VYTANILLSGANTYKLTPTQWFFREG----S 102
Cdd:cd15964    5 IVVWFVNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIylLLIASVDLHTRSEYYNHAIDWQTGPGcntaG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 103 MFVALAA--SVFSLLAIAIER-HLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGwncIDSINNCSTVLPL--- 176
Cdd:cd15964   85 FFTVFASelSVYTLTVITLERwYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVG---VSSYAKVSICLPMdte 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395 177 --YHKAYILFCTTVFSVILMAIVILYARIYALVRTRSRKlvfrkvangrgsnkSSEKSMALLKTVIIVLSCFIACWAPLF 254
Cdd:cd15964  162 tpLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYK--------------SGDKDTKIAKRMAVLIFTDFICMAPIS 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 982742395 255 ILLLLDVACQTLTcsILYKAEWFLALAV-LNSAMNPLIYTLTSNEMRR 301
Cdd:cd15964  228 FYALSAILNKPLI--TVSNSKILLVLFYpLNSCANPFLYAIFTKAFRR 273
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
35-71 7.08e-03

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 37.63  E-value: 7.08e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 982742395  35 CCFII--LENVLVLLTIWRTKKFHKPMYYFIGNLALSDL 71
Cdd:cd15953    9 LMYIVtlLGNCTILFVVGKEQSLHKPMYLLLCMLALTDL 47
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
29-127 7.49e-03

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 37.79  E-value: 7.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANIL---LSGANT--YKLTPTQWFFREgsm 103
Cdd:cd15937    5 VLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLadfFSERKTisYGGCMAQLFFLH--- 81
                         90       100
                 ....*....|....*....|....
gi 982742395 104 FVAlAASVFSLLAIAIERHLTMLK 127
Cdd:cd15937   82 FLG-AAEMFLLVAMAYDRYVAICK 104
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
35-307 7.50e-03

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 37.57  E-value: 7.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395   35 CCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL--LAGVVYTANILLSGantYKLTPTQWFFREGSMFVALAASVF 112
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLicLCGEIVFVVLLFTG---TQLTRNECFWMISFYIFGQTAQGP 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  113 SLLAIAIERhLTMLKMKLHnngktcrvFMLISTVWFIAAILggLPVMGWNCI-----------DSINNCSTVLPLYHKAY 181
Cdd:pfam10320  78 LMLMIGIDR-LIAVKFPIF--------YRLLSSSKYLFIQL--IFPVIYSSFitvygflqrddETIIVCAPPLALPGTAF 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  182 ILFCTTVFsVILMAIVILYARIYALVRTrsrklvfrkvaNGRGSNKSSEKSMALLKTVIIVlscFIACWaplFILLLLDV 261
Cdd:pfam10320 147 TIFTLSSL-FINVIVLIVYIILIIIFKN-----------KKQSQNSDSKKVFKSLQVTVVI---FIFGW---FTSTIANT 208
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 982742395  262 ACQTLTCSILYKAEWFL---ALAVLNSAMNPLIYTLTSNEMRRAFIKML 307
Cdd:pfam10320 209 VFLYLTEDGEVEVIIQMyagFFVLLSFSQNFFVTYWRSSEYRKAFRSLW 257
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
31-71 7.61e-03

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 37.83  E-value: 7.61e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 982742395  31 FIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDL 71
Cdd:cd15955    7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDL 47
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
39-121 8.32e-03

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 37.65  E-value: 8.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  39 ILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTAN---ILLSGANTYKLTP--TQWFFREgsMFVALAASVfs 113
Cdd:cd15917   15 LLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKmlgIFWFNAREISFDAclAQMFFIH--SFTAMESGV-- 90

                 ....*...
gi 982742395 114 LLAIAIER 121
Cdd:cd15917   91 LLAMAFDR 98
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
29-156 9.49e-03

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 37.39  E-value: 9.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742395  29 VVFIIVCCFIILENVLVLLTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILL-----SGANTYKLTPTQWFFregsM 103
Cdd:cd15415    5 MLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVnflveKKTISYSACIAQHFF----F 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982742395 104 FVALAASVFSLLAIAIERHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGL 156
Cdd:cd15415   81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSL 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure