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Conserved domains on  [gi|54306071|ref|NP_571310|]
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transcription factor GATA-5 [Danio rerio]

Protein Classification

GATA-type transcription factor( domain architecture ID 12062858)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0006355|GO:0008270|GO:0043565|GO:0000981
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-173 7.74e-79

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


:

Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 240.03  E-value: 7.74e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54306071     1 MYSSLALSSNPSP--YAHDSGNYIHPSASSPVYVPTTRVPAMLQTLPYLQTCESSHQAHGISSHHAWPQTGTDNSSFNPG 78
Cdd:pfam05349   1 MYQSLALAANHGQaaYDHDSGGFLHSAASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVSSHSGWAQAGAESSSYNPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54306071    79 SPHPPPGFSYSHSPPVSSSTGRDAAYQNPLMLSNGGRaDQYGsALVRSVGGSYSSPYAAYMSPEMATSWTPGPFDGGMI- 157
Cdd:pfam05349  81 SPHPSPRFSYSHSPPGSNGTSRDAAYQSPLLISAGGR-EQYG-ALGRPLGGSYPSPYPAYVSPEMAPSWTAGPFDSSVLh 158

                         170
                  ....*....|....*.
gi 54306071   158 GLQGRQGTLPGRRSSI 173
Cdd:pfam05349 159 SLQGRGAPLPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 241-291 7.93e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 82.04  E-value: 7.93e-20
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 54306071 241 CTNCHTSTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKES-IQTRKRK 291
Cdd:cd00202   2 CSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 185-236 2.97e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 77.80  E-value: 2.97e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 54306071 185 ECVNCGSISTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQKRLQSTSRR 236
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRNR 53
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-173 7.74e-79

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 240.03  E-value: 7.74e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54306071     1 MYSSLALSSNPSP--YAHDSGNYIHPSASSPVYVPTTRVPAMLQTLPYLQTCESSHQAHGISSHHAWPQTGTDNSSFNPG 78
Cdd:pfam05349   1 MYQSLALAANHGQaaYDHDSGGFLHSAASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVSSHSGWAQAGAESSSYNPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54306071    79 SPHPPPGFSYSHSPPVSSSTGRDAAYQNPLMLSNGGRaDQYGsALVRSVGGSYSSPYAAYMSPEMATSWTPGPFDGGMI- 157
Cdd:pfam05349  81 SPHPSPRFSYSHSPPGSNGTSRDAAYQSPLLISAGGR-EQYG-ALGRPLGGSYPSPYPAYVSPEMAPSWTAGPFDSSVLh 158

                         170
                  ....*....|....*.
gi 54306071   158 GLQGRQGTLPGRRSSI 173
Cdd:pfam05349 159 SLQGRGAPLPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 241-291 7.93e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 82.04  E-value: 7.93e-20
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 54306071 241 CTNCHTSTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKES-IQTRKRK 291
Cdd:cd00202   2 CSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 185-236 2.97e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 77.80  E-value: 2.97e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 54306071 185 ECVNCGSISTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQKRLQSTSRR 236
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRNR 53
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
236-285 5.29e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 74.38  E-value: 5.29e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 54306071    236 RAGLCCTNCHTSTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMKKESI 285
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
182-228 6.62e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.52  E-value: 6.62e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 54306071    182 EGRECVNCGSISTPLWRRDGTGH-YLCNACGLYHKMNGINRPLIKPQK 228
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLKRPLSLKK 49
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 241-275 4.56e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 4.56e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 54306071   241 CTNCHTSTTTLWRRNAEGEP-VCNACGLYMKLHGVP 275
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 186-218 5.86e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 59.64  E-value: 5.86e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 54306071   186 CVNCGSISTPLWRRDGTGHY-LCNACGLYHKMNG 218
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
169-327 2.99e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.18  E-value: 2.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54306071 169 RRSSIDMLDDLPCEGRECVNCGSISTPLWRRD-----GTGHYLCNACGLYHKMNGINRPLIKpQKRLQSTSRRAGLCCTN 243
Cdd:COG5641 144 SLNPNNNQSDNSNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPIS-LKSDSIKSRSSRSSHNN 222

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54306071 244 C-HTSTTTLWRRNAEGEPVCNACGLYMKLHGvpRPLAMKKESIQTRKRKPKMPKTKSSSGSTvSGATSPTslPVSENAST 322
Cdd:COG5641 223 NdSNGENANTESIGNSSASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKSPLLEGLMGST-SLQPVST--PKLVLPSD 297


                ....*
gi 54306071 323 IKSEP 327
Cdd:COG5641 298 KKRST 302
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-173 7.74e-79

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 240.03  E-value: 7.74e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54306071     1 MYSSLALSSNPSP--YAHDSGNYIHPSASSPVYVPTTRVPAMLQTLPYLQTCESSHQAHGISSHHAWPQTGTDNSSFNPG 78
Cdd:pfam05349   1 MYQSLALAANHGQaaYDHDSGGFLHSAASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVSSHSGWAQAGAESSSYNPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54306071    79 SPHPPPGFSYSHSPPVSSSTGRDAAYQNPLMLSNGGRaDQYGsALVRSVGGSYSSPYAAYMSPEMATSWTPGPFDGGMI- 157
Cdd:pfam05349  81 SPHPSPRFSYSHSPPGSNGTSRDAAYQSPLLISAGGR-EQYG-ALGRPLGGSYPSPYPAYVSPEMAPSWTAGPFDSSVLh 158

                         170
                  ....*....|....*.
gi 54306071   158 GLQGRQGTLPGRRSSI 173
Cdd:pfam05349 159 SLQGRGAPLPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 241-291 7.93e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 82.04  E-value: 7.93e-20
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 54306071 241 CTNCHTSTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKES-IQTRKRK 291
Cdd:cd00202   2 CSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 185-236 2.97e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 77.80  E-value: 2.97e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 54306071 185 ECVNCGSISTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQKRLQSTSRR 236
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRNR 53
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
236-285 5.29e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 74.38  E-value: 5.29e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 54306071    236 RAGLCCTNCHTSTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMKKESI 285
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
182-228 6.62e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.52  E-value: 6.62e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 54306071    182 EGRECVNCGSISTPLWRRDGTGH-YLCNACGLYHKMNGINRPLIKPQK 228
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLKRPLSLKK 49
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 241-275 4.56e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 4.56e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 54306071   241 CTNCHTSTTTLWRRNAEGEP-VCNACGLYMKLHGVP 275
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 186-218 5.86e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 59.64  E-value: 5.86e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 54306071   186 CVNCGSISTPLWRRDGTGHY-LCNACGLYHKMNG 218
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
169-327 2.99e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.18  E-value: 2.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54306071 169 RRSSIDMLDDLPCEGRECVNCGSISTPLWRRD-----GTGHYLCNACGLYHKMNGINRPLIKpQKRLQSTSRRAGLCCTN 243
Cdd:COG5641 144 SLNPNNNQSDNSNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPIS-LKSDSIKSRSSRSSHNN 222

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54306071 244 C-HTSTTTLWRRNAEGEPVCNACGLYMKLHGvpRPLAMKKESIQTRKRKPKMPKTKSSSGSTvSGATSPTslPVSENAST 322
Cdd:COG5641 223 NdSNGENANTESIGNSSASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKSPLLEGLMGST-SLQPVST--PKLVLPSD 297


                ....*
gi 54306071 323 IKSEP 327
Cdd:COG5641 298 KKRST 302
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
188-321 6.14e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 47.94  E-value: 6.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54306071 188 NCGSISTPLWRR-DGTGHYLCNACGLYHKMNGINRPLIKPQKrlqSTSRRAGLCCTNCHTSTTTLWRrnaEGEPVCNACG 266
Cdd:COG5641 303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPLLPKPD---PNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPG 376

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 54306071 267 LYMKLHGVPRPLAMKKESIQTRKRKP-KMPKTKSSSGSTVSGATSPTSLPVSENAS 321
Cdd:COG5641 377 AQVKLPNQTRSTGATKKKITRRRMNSgKIPALSSSMKNPVPKEFSPLIPQSTESET 432
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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