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Conserved domains on  [gi|18859243|ref|NP_571145|]
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midkine a precursor [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTN_MK_N super family cl02505
PTN/MK heparin-binding protein family, N-terminal domain;
39-118 5.00e-40

PTN/MK heparin-binding protein family, N-terminal domain;


The actual alignment was detected with superfamily member smart00193:

Pssm-ID: 470593  Cd Length: 80  Bit Score: 129.23  E-value: 5.00e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859243     39 CAEWLYGSCVANNGDCGQGMREGTCNEQTRKVKCRVPCNWKKEFGADCKYKFGNWGECDAATSTKSRTGTLQKALFNVEC 118
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGTCGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKALYNADC 80
 
Name Accession Description Interval E-value
PTN smart00193
Pleiotrophin / midkine family; Heparin-binding domain family.
 39-118 5.00e-40

Pleiotrophin / midkine family; Heparin-binding domain family.


Pssm-ID: 128490  Cd Length: 80  Bit Score: 129.23  E-value: 5.00e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859243     39 CAEWLYGSCVANNGDCGQGMREGTCNEQTRKVKCRVPCNWKKEFGADCKYKFGNWGECDAATSTKSRTGTLQKALFNVEC 118
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGTCGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKALYNADC 80
PTN_MK_N pfam05196
PTN/MK heparin-binding protein family, N-terminal domain;
37-82 2.41e-25

PTN/MK heparin-binding protein family, N-terminal domain;


Pssm-ID: 461582  Cd Length: 57  Bit Score: 91.36  E-value: 2.41e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 18859243    37 ADCAEWLYGSCVANNGDCGQGMREGTCNEQTRKVKCRVPCNWKKEF 82
Cdd:pfam05196  12 SDCAEWQWGKCVPNSGDCGLGFREGTCKEQTKKIKCKIPCNWKKEF 57
 
Name Accession Description Interval E-value
PTN smart00193
Pleiotrophin / midkine family; Heparin-binding domain family.
 39-118 5.00e-40

Pleiotrophin / midkine family; Heparin-binding domain family.


Pssm-ID: 128490  Cd Length: 80  Bit Score: 129.23  E-value: 5.00e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859243     39 CAEWLYGSCVANNGDCGQGMREGTCNEQTRKVKCRVPCNWKKEFGADCKYKFGNWGECDAATSTKSRTGTLQKALFNVEC 118
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGTCGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKALYNADC 80
PTN_MK_N pfam05196
PTN/MK heparin-binding protein family, N-terminal domain;
37-82 2.41e-25

PTN/MK heparin-binding protein family, N-terminal domain;


Pssm-ID: 461582  Cd Length: 57  Bit Score: 91.36  E-value: 2.41e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 18859243    37 ADCAEWLYGSCVANNGDCGQGMREGTCNEQTRKVKCRVPCNWKKEF 82
Cdd:pfam05196  12 SDCAEWQWGKCVPNSGDCGLGFREGTCKEQTKKIKCKIPCNWKKEF 57
PTN_MK_C pfam01091
PTN/MK heparin-binding protein family, C-terminal domain;
83-130 8.78e-24

PTN/MK heparin-binding protein family, C-terminal domain;


Pssm-ID: 460059  Cd Length: 65  Bit Score: 87.51  E-value: 8.78e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18859243    83 GADCKYKFGNWGECDAATSTKSRTGTLQKALFNVECQQTVSVTKPCTT 130
Cdd:pfam01091   1 GADCKYKFGAWGECDPATGTKTRTGTLKKALFNAECQQTVSVTKPCKP 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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