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Conserved domains on  [gi|18390333|ref|NP_569058|]
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ankyrin repeat and SOCS box protein 14 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 244-300 1.18e-36

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239700  Cd Length: 57  Bit Score: 125.34  E-value: 1.18e-36
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18390333 244 TNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTG 300
Cdd:cd03730   1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQGIFTG 57
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-159 1.91e-18

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.46  E-value: 1.91e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333  10 LRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNfmldqrinkHYDDHRKSALYFAVSNSDLSSVKL 89
Cdd:COG0666  68 LVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN---------ARDKDGETPLHLAAYNGNLEIVKL 138

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18390333  90 LLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLHFpsALQYtlKDEVMLRMLLNYG 159
Cdd:COG0666 139 LLEAGADVNAqdnDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNdgETPLHL--AAEN--GHLEIVKLLLEAG 209
 
Name Accession Description Interval E-value
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 244-300 1.18e-36

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 125.34  E-value: 1.18e-36
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18390333 244 TNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTG 300
Cdd:cd03730   1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQGIFTG 57
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-159 1.91e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.46  E-value: 1.91e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333  10 LRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNfmldqrinkHYDDHRKSALYFAVSNSDLSSVKL 89
Cdd:COG0666  68 LVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN---------ARDKDGETPLHLAAYNGNLEIVKL 138

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18390333  90 LLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLHFpsALQYtlKDEVMLRMLLNYG 159
Cdd:COG0666 139 LLEAGADVNAqdnDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNdgETPLHL--AAEN--GHLEIVKLLLEAG 209
Ank_2 pfam12796
Ankyrin repeats (3 copies);
34-128 3.01e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 3.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333    34 HCAAAGAHPQCLELLIQAGFDVNFMldqrinkhyDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDP-VNCLQIALRMG 112
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNgRTALHYAARSG 72

                          90
                  ....*....|....*.
gi 18390333   113 NYELISLLLRHGANVN 128
Cdd:pfam12796  73 HLEIVKLLLEKGADIN 88
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 245-286 5.09e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 53.71  E-value: 5.09e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 18390333   245 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVL 286
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGK---RRLGAIDKLPLPPLLKDYLL 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 26-161 1.02e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   26 KQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMldqrinkhyDDHRKSALYFAVSNSDLSSVKLLLSAGAlpNQDPVNC- 104
Cdd:PHA02878 165 RHKGNTALHYATENKDQRLTELLLSYGANVNIP---------DKTNNSPLHHAVKHYNKPIVHILLENGA--STDARDKc 233

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18390333  105 ----LQIAL-RMGNYELISLLLRHGANVNYFCRVNPLhfpSALQYTLKDEVMLRMLLNYGYD 161
Cdd:PHA02878 234 gntpLHISVgYCKDYDILKLLLEHGVDVNAKSYILGL---TALHSSIKSERKLKLLLEYGAD 292
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 247-288 1.06e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 47.40  E-value: 1.06e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 18390333    247 RSLKHLCRLKIRKCMGrlhlrcpvFMSFLPLPNRLKAYVLYK 288
Cdd:smart00969   1 RSLQHLCRLAIRRSLG--------GIDKLPLPPRLKDYLLYY 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 103-129 6.83e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.72  E-value: 6.83e-03
                           10        20
                   ....*....|....*....|....*..
gi 18390333    103 NCLQIALRMGNYELISLLLRHGANVNY 129
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 244-300 1.18e-36

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 125.34  E-value: 1.18e-36
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18390333 244 TNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTG 300
Cdd:cd03730   1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQGIFTG 57
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-159 1.91e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.46  E-value: 1.91e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333  10 LRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNfmldqrinkHYDDHRKSALYFAVSNSDLSSVKL 89
Cdd:COG0666  68 LVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN---------ARDKDGETPLHLAAYNGNLEIVKL 138

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18390333  90 LLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLHFpsALQYtlKDEVMLRMLLNYG 159
Cdd:COG0666 139 LLEAGADVNAqdnDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNdgETPLHL--AAEN--GHLEIVKLLLEAG 209
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 245-297 1.07e-17

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 75.25  E-value: 1.07e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 18390333 245 NPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGI 297
Cdd:cd03731   2 NPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQEL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-128 1.92e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.77  E-value: 1.92e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333  21 DLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNfmldqrinkHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LP 97
Cdd:COG0666 112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN---------AQDNDGNTPLHLAAANGNLEIVKLLLEAGAdvnAR 182

                        90       100       110
                ....*....|....*....|....*....|.
gi 18390333  98 NQDPVNCLQIALRMGNYELISLLLRHGANVN 128
Cdd:COG0666 183 DNDGETPLHLAAENGHLEIVKLLLEAGADVN 213
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 245-288 8.61e-16

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 69.83  E-value: 8.61e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 18390333 245 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVLYK 288
Cdd:cd03716   2 TPRSLQHLCRLAIRRCLGR---RRLELIKKLPLPPRLKDYLLYE 42
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 245-288 7.46e-14

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 64.41  E-value: 7.46e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 18390333 245 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVLYK 288
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGK---RRLDLIDKLPLPPRLKDYLLYK 41
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-161 3.62e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.44  E-value: 3.62e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   1 MLKCILKFFLRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNfmldqrinkHYDDHRKSALYFAVS 80
Cdd:COG0666  26 LAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN---------AKDDGGNTLLHAAAR 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333  81 NSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGANVNY--FCRVNPLHFpsALQYtlKDEVMLRML 155
Cdd:COG0666  97 NGDLEIVKLLLEAGADVNArdkDGETPLHLAAYNGNLEIVKLLLEAGADVNAqdNDGNTPLHL--AAAN--GNLEIVKLL 172


                ....*.
gi 18390333 156 LNYGYD 161
Cdd:COG0666 173 LEAGAD 178
Ank_2 pfam12796
Ankyrin repeats (3 copies);
34-128 3.01e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 3.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333    34 HCAAAGAHPQCLELLIQAGFDVNFMldqrinkhyDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDP-VNCLQIALRMG 112
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNgRTALHYAARSG 72

                          90
                  ....*....|....*.
gi 18390333   113 NYELISLLLRHGANVN 128
Cdd:pfam12796  73 HLEIVKLLLEKGADIN 88
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 245-286 5.09e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 53.71  E-value: 5.09e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 18390333   245 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVL 286
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGK---RRLGAIDKLPLPPLLKDYLL 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
75-161 7.17e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.34  E-value: 7.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333    75 LYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFpsALQYTLKDevM 151
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAdanLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRTALHY--AARSGHLE--I 76

                          90
                  ....*....|
gi 18390333   152 LRMLLNYGYD 161
Cdd:pfam12796  77 VKLLLEKGAD 86
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 26-161 1.02e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   26 KQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMldqrinkhyDDHRKSALYFAVSNSDLSSVKLLLSAGAlpNQDPVNC- 104
Cdd:PHA02878 165 RHKGNTALHYATENKDQRLTELLLSYGANVNIP---------DKTNNSPLHHAVKHYNKPIVHILLENGA--STDARDKc 233

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18390333  105 ----LQIAL-RMGNYELISLLLRHGANVNYFCRVNPLhfpSALQYTLKDEVMLRMLLNYGYD 161
Cdd:PHA02878 234 gntpLHISVgYCKDYDILKLLLEHGVDVNAKSYILGL---TALHSSIKSERKLKLLLEYGAD 292
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 247-288 1.06e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 47.40  E-value: 1.06e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 18390333    247 RSLKHLCRLKIRKCMGrlhlrcpvFMSFLPLPNRLKAYVLYK 288
Cdd:smart00969   1 RSLQHLCRLAIRRSLG--------GIDKLPLPPRLKDYLLYY 34
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 17-159 2.39e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.50  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   17 IPVTDLAAIKqsgispvhcaaAGAHpQCLELLIQAGFD-------------VNFMLDQRINKHYDDHR-KSALYFAVSNS 82
Cdd:PHA02874  68 IPHPLLTAIK-----------IGAH-DIIKLLIDNGVDtsilpipciekdmIKTILDCGIDVNIKDAElKTFLHYAIKKG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   83 DLSSVKLLLSAGALPNQDPVNC---LQIALRMGNYELISLLLRHGA--NVNYFCRVNPLHFpsALQYtlKDEVMLRMLLN 157
Cdd:PHA02874 136 DLESIKMLFEYGADVNIEDDNGcypIHIAIKHNFFDIIKLLLEKGAyaNVKDNNGESPLHN--AAEY--GDYACIKLLID 211


                 ..
gi 18390333  158 YG 159
Cdd:PHA02874 212 HG 213
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 244-288 2.99e-07

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 46.14  E-value: 2.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 18390333    244 TNPRSLKHLCRLKIRKCMGRLHLRCpvfmsfLPLPNRLKAYVLYK 288
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTDQIKT------LPLPPKLKDYLSYY 43
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 244-288 4.12e-07

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 45.67  E-value: 4.12e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18390333 244 TNPRSLKHLCRLKIRKCMGRLHLRCpvfmsfLPLPNRLKAYVLYK 288
Cdd:cd03717   1 TSVRSLQHLCRFVIRQCTRRDLIDQ------LPLPRRLKDYLKEY 39
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 248-289 4.93e-07

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 45.94  E-value: 4.93e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18390333 248 SLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKE 289
Cdd:cd03722   5 SLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSD 46
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-129 6.38e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.95  E-value: 6.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333  21 DLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNfmldqrinkHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQD 100
Cdd:COG0666 178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN---------AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                        90       100       110
                ....*....|....*....|....*....|..
gi 18390333 101 PVNCLQ---IALRMGNYELISLLLRHGANVNY 129
Cdd:COG0666 249 DKDGLTallLAAAAGAALIVKLLLLALLLLAA 280
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 25-162 1.05e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.60  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   25 IKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMldqrinkhyDDHRKSALYFAVSNSDLSSVKLLLSAGALPN-QDPVN 103
Cdd:PHA02875  98 FYKDGMTPLHLATILKKLDIMKLLIARGADPDIP---------NTDKFSPLHLAVMMGDIKGIELLIDHKACLDiEDCCG 168

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18390333  104 C--LQIALRMGNYELISLLLRHGANVNYFCRvNPLhfPSALQYTLKDEV--MLRMLLNYGYDT 162
Cdd:PHA02875 169 CtpLIIAMAKGDIAICKMLLDSGANIDYFGK-NGC--VAALCYAIENNKidIVRLFIKRGADC 228
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 245-286 1.71e-06

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 44.35  E-value: 1.71e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18390333 245 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVL 286
Cdd:cd03723   2 TPRSLQHLCRCAIRKLLGS---RCHKLVPQLSLPTSLKNYLL 40
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 45-161 3.04e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.34  E-value: 3.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   45 LELLIQAGFDVNfmldqRINKHYDdhrKSALYFAVSNSDLSSVKLLLSAGALPNQdPVNC----LQIALRMGNYELISLL 120
Cdd:PHA02878 150 TKLLLSYGADIN-----MKDRHKG---NTALHYATENKDQRLTELLLSYGANVNI-PDKTnnspLHHAVKHYNKPIVHIL 220

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 18390333  121 LRHGANVNY--FCRVNPLHFPSAlqyTLKDEVMLRMLLNYGYD 161
Cdd:PHA02878 221 LENGASTDArdKCGNTPLHISVG---YCKDYDILKLLLEHGVD 260
Ank_2 pfam12796
Ankyrin repeats (3 copies);
10-99 4.29e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 4.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333    10 LRALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQagfdvnfmldqRINKHYDDHRKSALYFAVSNSDLSSVK 88
Cdd:pfam12796  10 LELVKLLLENgADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----------HADVNLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 18390333    89 LLLSAGALPNQ 99
Cdd:pfam12796  79 LLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 55-161 6.71e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.97  E-value: 6.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   55 VNFMLDQRINKH-YDDHRKSALYF-----AVSNSDLSSVKLLLSAGALPN-QDPVNC--LQIAL--RMGNYELISLLLRH 123
Cdd:PHA03100  51 VKILLDNGADINsSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVNaPDNNGItpLLYAIskKSNSYSIVEYLLDN 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 18390333  124 GANVN--YFCRVNPLHFpsALQYTLKDEVMLRMLLNYGYD 161
Cdd:PHA03100 131 GANVNikNSDGENLLHL--YLESNKIDLKILKLLIDKGVD 168
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 246-289 7.10e-06

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 42.55  E-value: 7.10e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 18390333 246 PRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLYKE 289
Cdd:cd03721   3 PRPLAHLCRLKVRTLIGINRIK---LIDTLPLPPRLIRYLNHQE 43
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 21-132 1.26e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.20  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   21 DLAAIKQSGISPVHCAAAGAHP--QCLELLIQAGFDVNFM--LDQRINKHYDDHRK-----SALYFAVSNSDLSSVKLLL 91
Cdd:PHA03100 133 NVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAKnrVNYLLSYGVPINIKdvygfTPLHYAVYNNNPEFVKYLL 212

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 18390333   92 SAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNYFCR 132
Cdd:PHA03100 213 DLGANPNlvnKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 246-288 2.28e-05

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 40.75  E-value: 2.28e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 18390333 246 PRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLYK 288
Cdd:cd03718   3 PLPLMDLCRRRVRVALGRDRLE---EIEQLPLPPSLKNYLLYQ 42
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 246-291 3.54e-05

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 40.60  E-value: 3.54e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 18390333 246 PRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLYKEYD 291
Cdd:cd03726   3 PRTLQDLCRIKIRHCIGLQNLK---LLDELPIAKVMKDYLKHKFDD 45
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 244-290 7.56e-05

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 39.45  E-value: 7.56e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 18390333 244 TNPRSLKHLCRLKIRKCMGRLHLrcpvfmsfLPLPNRLKAYVlyKEY 290
Cdd:cd03736   1 TSTPSLQHLCRITINKCTRQIQE--------LPLPTRLKDYL--TEY 37
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-161 1.04e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.02  E-value: 1.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333  21 DLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQD 100
Cdd:COG0666   3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18390333 101 PVN----CLQIALRMGNYELISLLLRHGANVNY--FCRVNPLHFpsALQYtlKDEVMLRMLLNYGYD 161
Cdd:COG0666  83 KDDggntLLHAAARNGDLEIVKLLLEAGADVNArdKDGETPLHL--AAYN--GNLEIVKLLLEAGAD 145
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 245-290 2.38e-04

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 38.15  E-value: 2.38e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 18390333 245 NPRSLKHLCRLKIRKCMGRLHLRCpvfmsfLPLPNRLKAYVLYKEY 290
Cdd:cd03741   2 NVQSLQHLCRFVIRKLVRRDHIPA------LPLPRRLIDYLREKHY 41
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 246-288 2.42e-04

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 37.93  E-value: 2.42e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18390333 246 PRSLKHLCRLKIRKCMG--RLHLrcpvfMSFLPLPNRLKAYVLYK 288
Cdd:cd03724   3 PSSLCQLCRLCIRNYIGrsRLHL-----IPQLQLPTLLKNFLQYR 42
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 245-287 2.45e-04

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 38.17  E-value: 2.45e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 18390333 245 NPRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLY 287
Cdd:cd03720   2 NPRSLLSLCRIAVRRALGKQRLS---LICSLPLPDPIKKFLLH 41
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 246-288 3.51e-04

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 37.69  E-value: 3.51e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 18390333 246 PRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLYK 288
Cdd:cd03719   3 PHSLLHLSRLCVRHALGDTRLG---QVSALPLPPAMKRYLLYQ 42
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 247-290 8.57e-04

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 36.24  E-value: 8.57e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 18390333 247 RSLKHLCRLKIRKCMGRLHLRcpvfmsFLPLPNRLKAYVLYKEY 290
Cdd:cd03740   4 RSLQYLCRFVIRQYTRIDLIQ------KLPLPNKMKGYLLEKHY 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 30-246 8.85e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 8.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   30 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLdqrinkhYDDhrKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQiAL 109
Cdd:PHA02876 179 ITPIHYAAERGNAKMVNLLLSYGADVNIIA-------LDD--LSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLK-AI 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333  110 RMGNYELISLLLRHGANVNYF--CRVNPLHF-----------PSALQY-------TLKDEVMLRMLLNYGYDTE------ 163
Cdd:PHA02876 249 RNEDLETSLLLYDAGFSVNSIddCKNTPLHHasqapslsrlvPKLLERgadvnakNIKGETPLYLMAKNGYDTEnirtli 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333  164 -RCFDCPHGDK-----VHPSYTVEGWTSTVI---------KDTKFCEVITLSWLQHLSGKV-VRVMLDYvdqvriCSKLK 227
Cdd:PHA02876 329 mLGADVNAADRlyitpLHQASTLDRNKDIVItllelganvNARDYCDKTPIHYAAVRNNVViINTLLDY------GADIE 402

                        250       260
                 ....*....|....*....|.
gi 18390333  228 AVLQKQGiwSEIHFIL--TNP 246
Cdd:PHA02876 403 ALSQKIG--TALHFALcgTNP 421
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 245-288 9.27e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 36.30  E-value: 9.27e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 18390333 245 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVLYK 288
Cdd:cd03729   2 TPLSLQQLCRINLRKALGT---RALEKIAKLNIPNRIIDYLSYN 42
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 57-176 9.29e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.36  E-value: 9.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   57 FMLDQRINKHYDDHRK-SALYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVN---Y 129
Cdd:PHA02875  20 RLLDIGINPNFEIYDGiSPIKLAMKFRDSEAIKLLMKHGAIPDvkyPDIESELHDAVEEGDVKAVEELLDLGKFADdvfY 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 18390333  130 FCRVNPLHFPSALQytlKDEVMlRMLLNYGYDTercfDCPHGDKVHP 176
Cdd:PHA02875 100 KDGMTPLHLATILK---KLDIM-KLLIARGADP----DIPNTDKFSP 138
Ank_4 pfam13637
Ankyrin repeats (many copies);
31-91 9.34e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 9.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18390333    31 SPVHCAAAGAHPQCLELLIQAGFDVNfmlDQRINKhyddhrKSALYFAVSNSDLSSVKLLL 91
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN---AVDGNG------ETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 21-161 1.00e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   21 DLAAIKQSGISPVHC-AAAGAHPQCLELLIQAGFDVNFMldqrinkhyDDHRKSAL--YFAVSNSDLSSVKLLLSAGALP 97
Cdd:PHA03095  75 DVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAK---------DKVGRTPLhvYLSGFNINPKVIRLLLRKGADV 145

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18390333   98 N---QDPVNCLQIALRMGN--YELISLLLRHGANVNY--FCRVNPLHfpSALQYTLKDEVMLRMLLNYGYD 161
Cdd:PHA03095 146 NaldLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAvdDRFRSLLH--HHLQSFKPRARIVRELIRAGCD 214
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 246-286 1.38e-03

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 35.88  E-value: 1.38e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 18390333 246 PRSLKHLCRLKIRKCMGRLHLRCPVfmSFLPLPNRLKAYVL 286
Cdd:cd03725   3 PPPLKHLCRVFIRLCLRPWPVDVKV--KALPLPDRLKWYLL 41
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 246-288 2.66e-03

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 34.96  E-value: 2.66e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 18390333 246 PRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLYK 288
Cdd:cd03744   3 PLPLMDLCRRSVRLALGRERLS---EIHTLPLPASLKNYLLYQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
73-121 2.90e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 2.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 18390333    73 SALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLL 121
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNgetALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 33-137 4.91e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 38.41  E-value: 4.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   33 VHCAAAGAHPQCLELLIQAGFDVNFmldQRINKHYDDHrksalyFAVSNSDLSSVKLLLSAGALPNQDPVNC---LQIAL 109
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNI---EDDNGCYPIH------IAIKHNFFDIIKLLLEKGAYANVKDNNGespLHNAA 198

                         90       100       110
                 ....*....|....*....|....*....|
gi 18390333  110 RMGNYELISLLLRHGANVNYFCR--VNPLH 137
Cdd:PHA02874 199 EYGDYACIKLLIDHGNHIMNKCKngFTPLH 228
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 103-129 6.83e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.72  E-value: 6.83e-03
                           10        20
                   ....*....|....*....|....*..
gi 18390333    103 NCLQIALRMGNYELISLLLRHGANVNY 129
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 246-288 8.07e-03

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 33.61  E-value: 8.07e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 18390333 246 PRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVLYK 288
Cdd:cd03728   3 PPSLMQLCRLCIRKCFGR---KQHHKIHKLHLPEPLKHFLLYR 42
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 29-127 9.32e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 37.54  E-value: 9.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18390333   29 GISPVHCAAAGAHPQCLELLIQAGFDVNF--------MLDQRINKHY-------------DDHRK-SALYFAVSNSDLSS 86
Cdd:PLN03192 558 GRTPLHIAASKGYEDCVLVLLKHACNVHIrdangntaLWNAISAKHHkifrilyhfasisDPHAAgDLLCTAAKRNDLTA 637

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 18390333   87 VKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANV 127
Cdd:PLN03192 638 MKELLKQGLnvdSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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