|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
41-361 |
9.48e-56 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 194.92 E-value: 9.48e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 41 DVIGAIEFDPTDNIVATAGISRKIRFYGLPSLLRNNavSGTGVSFVDQATAceyyictpAKLSSLRWRPGSGGRvIGSGD 120
Cdd:PLN00181 484 NLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDG--RDIHYPVVELASR--------SKLSGICWNSYIKSQ-VASSN 552
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 121 YDGVVMEYDLEKRTPVFERDEHGgRRVWSVDYTrhGGASTVGASGSDDGTMQVWDPRcpPEESVGVVRpagiCRSAVCCV 200
Cdd:PLN00181 553 FEGVVQVWDVARSQLVTEMKEHE-KRVWSIDYS--SADPTLLASGSDDGSVKLWSIN--QGVSIGTIK----TKANICCV 623
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 201 EFDPSGGPAVAVGCADRKGYVYDIRKLVDPALTLQGHTKTVSYVRFLDGGTVVTAGTDGCLKLWSVE------DGRVIRT 274
Cdd:PLN00181 624 QFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHS 703
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 275 YEGHVNNRNFVGLSVwrNGALFGCGSENNRVFVYDRRWGKPVWVDGFEPVGMNSGSD----KRFVSSVCWR-QSGvdqcT 349
Cdd:PLN00181 704 FMGHTNVKNFVGLSV--SDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVSGLEvddaSQFISSVCWRgQSS----T 777
|
330
....*....|..
gi 79518327 350 LVAGGSDGVLQV 361
Cdd:PLN00181 778 LVAANSTGNIKI 789
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
41-362 |
3.99e-24 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 100.49 E-value: 3.99e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 41 DVIGAIEFDPTDNIVATAGISRKIRFY-----GLPSLLRNNAVSGTGVSFVDQataceyyictpaklsslrwrpgsgGRV 115
Cdd:cd00200 10 GGVTCVAFSPDGKLLATGSGDGTIKVWdletgELLRTLKGHTGPVRDVAASAD------------------------GTY 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 116 IGSGDYDGVVMEYDLEKRTPVFERDEHGGRrVWSVDYTRHGgasTVGASGSDDGTMQVWDPrcPPEESVGVVRPagiCRS 195
Cdd:cd00200 66 LASGSSDKTIRLWDLETGECVRTLTGHTSY-VSSVAFSPDG---RILSSSSRDKTIKVWDV--ETGKCLTTLRG---HTD 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 196 AVCCVEFDPSGGpAVAVGCADRKGYVYDIR--KLVDpalTLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWSVEDGRVI 272
Cdd:cd00200 137 WVNSVAFSPDGT-FVASSSQDGTIKLWDLRtgKCVA---TLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 273 RTYEGHvnNRNFVGLSVWRNGALFGCGSENNRVFVYDrrwgkpvwVDGFEPVGMNSGSDKRfVSSVCWRQSGvdqCTLVA 352
Cdd:cd00200 213 GTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRVWD--------LRTGECVQTLSGHTNS-VTSLAWSPDG---KRLAS 278
|
330
....*....|
gi 79518327 353 GGSDGVLQVY 362
Cdd:cd00200 279 GSADGTIRIW 288
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
41-362 |
5.43e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 101.91 E-value: 5.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 41 DVIGAIEFDPTDNIVATAGISRKIRFYGLPSLLRNNAVSGTgvsfvdqataceyyictPAKLSSLRWRPGsgGRVIGSGD 120
Cdd:COG2319 121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH-----------------SGAVTSVAFSPD--GKLLASGS 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 121 YDGVVMEYDLEKRTPVFERDEHGGRrVWSVDYTRHGgaSTVgASGSDDGTMQVWDPRcppeeSVGVVRPAGICRSAVCCV 200
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLTGHTGA-VRSVAFSPDG--KLL-ASGSADGTVRLWDLA-----TGKLLRTLTGHSGSVRSV 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 201 EFDPSGgPAVAVGCADRKGYVYDIRKLvDPALTLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWSVEDGRVIRTYEGHV 279
Cdd:COG2319 253 AFSPDG-RLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 280 NNRNFVGLSvwRNGALFGCGSENNRVFVYDrrwgkpvwVDGFEPVGMNSGSDKRfVSSVCWRQSGvdqCTLVAGGSDGVL 359
Cdd:COG2319 331 GAVRSVAFS--PDGKTLASGSDDGTVRLWD--------LATGELLRTLTGHTGA-VTSVAFSPDG---RTLASGSADGTV 396
|
...
gi 79518327 360 QVY 362
Cdd:COG2319 397 RLW 399
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
233-265 |
9.03e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 9.03e-04
10 20 30
....*....|....*....|....*....|....
gi 79518327 233 TLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWS 265
Cdd:smart00320 7 TLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
233-265 |
4.57e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 34.63 E-value: 4.57e-03
10 20 30
....*....|....*....|....*....|....
gi 79518327 233 TLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWS 265
Cdd:pfam00400 6 TLEGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
41-361 |
9.48e-56 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 194.92 E-value: 9.48e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 41 DVIGAIEFDPTDNIVATAGISRKIRFYGLPSLLRNNavSGTGVSFVDQATAceyyictpAKLSSLRWRPGSGGRvIGSGD 120
Cdd:PLN00181 484 NLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDG--RDIHYPVVELASR--------SKLSGICWNSYIKSQ-VASSN 552
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 121 YDGVVMEYDLEKRTPVFERDEHGgRRVWSVDYTrhGGASTVGASGSDDGTMQVWDPRcpPEESVGVVRpagiCRSAVCCV 200
Cdd:PLN00181 553 FEGVVQVWDVARSQLVTEMKEHE-KRVWSIDYS--SADPTLLASGSDDGSVKLWSIN--QGVSIGTIK----TKANICCV 623
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 201 EFDPSGGPAVAVGCADRKGYVYDIRKLVDPALTLQGHTKTVSYVRFLDGGTVVTAGTDGCLKLWSVE------DGRVIRT 274
Cdd:PLN00181 624 QFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHS 703
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 275 YEGHVNNRNFVGLSVwrNGALFGCGSENNRVFVYDRRWGKPVWVDGFEPVGMNSGSD----KRFVSSVCWR-QSGvdqcT 349
Cdd:PLN00181 704 FMGHTNVKNFVGLSV--SDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVSGLEvddaSQFISSVCWRgQSS----T 777
|
330
....*....|..
gi 79518327 350 LVAGGSDGVLQV 361
Cdd:PLN00181 778 LVAANSTGNIKI 789
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
41-362 |
3.99e-24 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 100.49 E-value: 3.99e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 41 DVIGAIEFDPTDNIVATAGISRKIRFY-----GLPSLLRNNAVSGTGVSFVDQataceyyictpaklsslrwrpgsgGRV 115
Cdd:cd00200 10 GGVTCVAFSPDGKLLATGSGDGTIKVWdletgELLRTLKGHTGPVRDVAASAD------------------------GTY 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 116 IGSGDYDGVVMEYDLEKRTPVFERDEHGGRrVWSVDYTRHGgasTVGASGSDDGTMQVWDPrcPPEESVGVVRPagiCRS 195
Cdd:cd00200 66 LASGSSDKTIRLWDLETGECVRTLTGHTSY-VSSVAFSPDG---RILSSSSRDKTIKVWDV--ETGKCLTTLRG---HTD 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 196 AVCCVEFDPSGGpAVAVGCADRKGYVYDIR--KLVDpalTLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWSVEDGRVI 272
Cdd:cd00200 137 WVNSVAFSPDGT-FVASSSQDGTIKLWDLRtgKCVA---TLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 273 RTYEGHvnNRNFVGLSVWRNGALFGCGSENNRVFVYDrrwgkpvwVDGFEPVGMNSGSDKRfVSSVCWRQSGvdqCTLVA 352
Cdd:cd00200 213 GTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRVWD--------LRTGECVQTLSGHTNS-VTSLAWSPDG---KRLAS 278
|
330
....*....|
gi 79518327 353 GGSDGVLQVY 362
Cdd:cd00200 279 GSADGTIRIW 288
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
41-362 |
5.43e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 101.91 E-value: 5.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 41 DVIGAIEFDPTDNIVATAGISRKIRFYGLPSLLRNNAVSGTgvsfvdqataceyyictPAKLSSLRWRPGsgGRVIGSGD 120
Cdd:COG2319 121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH-----------------SGAVTSVAFSPD--GKLLASGS 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 121 YDGVVMEYDLEKRTPVFERDEHGGRrVWSVDYTRHGgaSTVgASGSDDGTMQVWDPRcppeeSVGVVRPAGICRSAVCCV 200
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLTGHTGA-VRSVAFSPDG--KLL-ASGSADGTVRLWDLA-----TGKLLRTLTGHSGSVRSV 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 201 EFDPSGgPAVAVGCADRKGYVYDIRKLvDPALTLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWSVEDGRVIRTYEGHV 279
Cdd:COG2319 253 AFSPDG-RLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 280 NNRNFVGLSvwRNGALFGCGSENNRVFVYDrrwgkpvwVDGFEPVGMNSGSDKRfVSSVCWRQSGvdqCTLVAGGSDGVL 359
Cdd:COG2319 331 GAVRSVAFS--PDGKTLASGSDDGTVRLWD--------LATGELLRTLTGHTGA-VTSVAFSPDG---RTLASGSADGTV 396
|
...
gi 79518327 360 QVY 362
Cdd:COG2319 397 RLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
111-362 |
2.25e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 100.37 E-value: 2.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 111 SGGRVIGSGDYDGVVMEYDLEKRTPVFERDEHGGRrVWSVDYTRHGgaSTVgASGSDDGTMQVWDPRcpPEESVGVVRPA 190
Cdd:COG2319 88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA-VRSVAFSPDG--KTL-ASGSADGTVRLWDLA--TGKLLRTLTGH 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 191 gicRSAVCCVEFDPSGgPAVAVGCADRKGYVYDIRKLvDPALTLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWSVEDG 269
Cdd:COG2319 162 ---SGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATG 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 270 RVIRTYEGHVNNRNFVGLSvwRNGALFGCGSENNRVFVYDRRWGKPVWVdgfepvgmnSGSDKRFVSSVCWRQSGVdqcT 349
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFS--PDGRLLASGSADGTVRLWDLATGELLRT---------LTGHSGGVNSVAFSPDGK---L 302
|
250
....*....|...
gi 79518327 350 LVAGGSDGVLQVY 362
Cdd:COG2319 303 LASGSDDGTVRLW 315
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
41-309 |
1.09e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 95.36 E-value: 1.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 41 DVIGAIEFDPTDNIVATAGISRKIRFYGLPSLLRNNAVSGTGVSfvdqataceyyictpakLSSLRWRPgsGGRVIGSGD 120
Cdd:COG2319 163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----------------VRSVAFSP--DGKLLASGS 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 121 YDGVVMEYDLEKRTPVFERDEHGGrRVWSVDYTRHGgaSTVgASGSDDGTMQVWDPrcppeESVGVVRPAGICRSAVCCV 200
Cdd:COG2319 224 ADGTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDG--RLL-ASGSADGTVRLWDL-----ATGELLRTLTGHSGGVNSV 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 201 EFDPSGGpAVAVGCADRKGYVYDIRKLvDPALTLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWSVEDGRVIRTYEGHV 279
Cdd:COG2319 295 AFSPDGK-LLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRTLTGHT 372
|
250 260 270
....*....|....*....|....*....|
gi 79518327 280 NNRNfvGLSVWRNGALFGCGSENNRVFVYD 309
Cdd:COG2319 373 GAVT--SVAFSPDGRTLASGSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
41-268 |
2.00e-17 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 83.04 E-value: 2.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 41 DVIGAIEFDPTDNIVATAGISRKIRFYGLPS--LLRNNAVSGTGVSfvdqataceyyictpaklsSLRWRPGsgGRVIGS 118
Cdd:COG2319 205 GAVRSVAFSPDGKLLASGSADGTVRLWDLATgkLLRTLTGHSGSVR-------------------SVAFSPD--GRLLAS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 119 GDYDGVVMEYDLEKRTPVFERDEHGGRrVWSVDYTRHGgaSTVgASGSDDGTMQVWDPRcpPEESVGVVRPAGicrSAVC 198
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLTGHSGG-VNSVAFSPDG--KLL-ASGSDDGTVRLWDLA--TGKLLRTLTGHT---GAVR 334
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 79518327 199 CVEFDPSGGPaVAVGCADRKGYVYDIRKLVdPALTLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWSVED 268
Cdd:COG2319 335 SVAFSPDGKT-LASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAFSpDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
140-362 |
3.89e-16 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 77.76 E-value: 3.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 140 DEHGGRrVWSVDYTRHGGastVGASGSDDGTMQVWDPRCPPEESVGVVRPAGICRSAVCCVefdpsgGPAVAVGCADRKG 219
Cdd:cd00200 6 KGHTGG-VTCVAFSPDGK---LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD------GTYLASGSSDKTI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 220 YVYDIRKLVDPAlTLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWSVEDGRVIRTYEGHvnnRNFV-GLSVWRNGALFG 297
Cdd:cd00200 76 RLWDLETGECVR-TLTGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVETGKCLTTLRGH---TDWVnSVAFSPDGTFVA 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79518327 298 CGSENNRVFVYDRRWGKPVWV-DGFEpvgmnsgsdkRFVSSVCWRQSGVdqcTLVAGGSDGVLQVY 362
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKCVATlTGHT----------GEVNSVAFSPDGE---KLLSSSSDGTIKLW 204
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
43-265 |
1.57e-13 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 70.06 E-value: 1.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 43 IGAIEFDPTDNIVATAGISRKIRFYGLPSllrnnavsgtgVSFVDQATACEYYIctpaklSSLRWRPGsgGRVIGSGDYD 122
Cdd:cd00200 96 VSSVAFSPDGRILSSSSRDKTIKVWDVET-----------GKCLTTLRGHTDWV------NSVAFSPD--GTFVASSSQD 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 123 GVVMEYDLEKRTPVFERDEHGGRrVWSVDYtrHGGASTVgASGSDDGTMQVWDPRCppEESVGVVRpagICRSAVCCVEF 202
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGE-VNSVAF--SPDGEKL-LSSSSDGTIKLWDLST--GKCLGTLR---GHENGVNSVAF 227
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 79518327 203 DPSGGpAVAVGCADRKGYVYDIRKlVDPALTLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWS 265
Cdd:cd00200 228 SPDGY-LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAWSpDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
233-362 |
7.61e-10 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 59.27 E-value: 7.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 233 TLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWSVEDGRVIRTYEGHvnNRNFVGLSVWRNGALFGCGSENNRVFVYDRR 311
Cdd:cd00200 4 TLKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLWDLE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 79518327 312 WGKPVWVdgFEpvgmnsgSDKRFVSSVCWRQSGVdqcTLVAGGSDGVLQVY 362
Cdd:cd00200 82 TGECVRT--LT-------GHTSYVSSVAFSPDGR---ILSSSSRDKTIKVW 120
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
230-362 |
4.97e-07 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 51.07 E-value: 4.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 230 PALTLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWSVEDGRVIRTYEGHVNNRNFVGLSvwRNGALFGCGSENNRVFVY 308
Cdd:COG2319 70 LLATLLGHTAAVLSVAFSpDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDGKTLASGSADGTVRLW 147
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 79518327 309 DRRWGKPVWVdgfepvgmnSGSDKRFVSSVCWRQSGVdqcTLVAGGSDGVLQVY 362
Cdd:COG2319 148 DLATGKLLRT---------LTGHSGAVTSVAFSPDGK---LLASGSDDGTVRLW 189
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
229-316 |
6.36e-04 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 41.42 E-value: 6.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79518327 229 DPALTLQGHTKTVSYVRFLDG--GTVVTAGTDGCLKLWSVEDGRVIRTYEGHVNnrNFVGLSVWRNGALFGCGSENNRVF 306
Cdd:PTZ00421 116 DPIVHLQGHTKKVGIVSFHPSamNVLASAGADMVVNVWDVERGKAVEVIKCHSD--QITSLEWNLDGSLLCTTSKDKKLN 193
|
90
....*....|
gi 79518327 307 VYDRRWGKPV 316
Cdd:PTZ00421 194 IIDPRDGTIV 203
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
233-265 |
9.03e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 9.03e-04
10 20 30
....*....|....*....|....*....|....
gi 79518327 233 TLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWS 265
Cdd:smart00320 7 TLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
233-265 |
4.57e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 34.63 E-value: 4.57e-03
10 20 30
....*....|....*....|....*....|....
gi 79518327 233 TLQGHTKTVSYVRFL-DGGTVVTAGTDGCLKLWS 265
Cdd:pfam00400 6 TLEGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
|
|
| |
