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Conserved domains on  [gi|18420521|ref|NP_568071|]
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Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/kelch-repeat protein( domain architecture ID 17778853)

F-box/kelch-repeat protein may be a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.120.10.80
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  10603472|31898225|11178263|31442578|24959344|10581972
SCOP:  4001927|3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
159-256 1.07e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.43  E-value: 1.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521 159 AWRKAPSMTVARANVFAYVINGKIYVMGGCAADESKYWAEVFDPKTQTWKPLTD-PGAELrvsSIIGMAVSEGKIYV--- 234
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPlPGPPR---HHAAAVAQDGKLYVfgg 78

                        90       100
                ....*....|....*....|....*....
gi 18420521 235 ------KNSYVKD-YVYDPEEDKWDVVAS 256
Cdd:COG3055  79 ftganpSSTPLNDvYVYDPATNTWTKLAP 107
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 19-63 2.40e-13

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438923  Cd Length: 45  Bit Score: 63.74  E-value: 2.40e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18420521  19 SFLSLPEEILVNCLARIPKSYYPKLSLVCKSFCSLILSMELYVER 63
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
159-256 1.07e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.43  E-value: 1.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521 159 AWRKAPSMTVARANVFAYVINGKIYVMGGCAADESKYWAEVFDPKTQTWKPLTD-PGAELrvsSIIGMAVSEGKIYV--- 234
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPlPGPPR---HHAAAVAQDGKLYVfgg 78

                        90       100
                ....*....|....*....|....*....
gi 18420521 235 ------KNSYVKD-YVYDPEEDKWDVVAS 256
Cdd:COG3055  79 ftganpSSTPLNDvYVYDPATNTWTKLAP 107
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 19-63 2.40e-13

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 63.74  E-value: 2.40e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18420521  19 SFLSLPEEILVNCLARIPKSYYPKLSLVCKSFCSLILSMELYVER 63
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 169-214 4.77e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.46  E-value: 4.77e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 18420521   169 ARANVFAYVINGKIYVMGGCAADESKYWAEVFDPKTQTWKPLTDPG 214
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 20-61 9.53e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 45.22  E-value: 9.53e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 18420521    20 FLSLPEEILVNCLARIPKSYYPKLSLVCKSFCSLILSMELYV 61
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
FBOX smart00256
A Receptor for Ubiquitination Targets;
23-63 2.67e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 43.58  E-value: 2.67e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 18420521     23 LPEEILVNCLARIPKSYYPKLSLVCKSFCSLILSMELYVER 63
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
PHA03098 PHA03098
kelch-like protein; Provisional
 146-271 1.35e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.99  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521  146 SSVMWVRDKTSIyaWRKAPSMTVARANVFAYVINGKIYVMGGCAADES----KYWA------------------------ 197
Cdd:PHA03098 311 NSVVSYDTKTKS--WNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlntvESWKpgeskwreepplifprynpcvvnv 388

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521  198 --------------------EVFDPKTQTWKpltdPGAELRVSSIIGMAVS-EGKIYVKN--SYVKD-------YVYDPE 247
Cdd:PHA03098 389 nnliyviggiskndellktvECFSLNTNKWS----KGSPLPISHYGGCAIYhDGKIYVIGgiSYIDNikvynivESYNPV 464

                        170       180
                 ....*....|....*....|....*..
gi 18420521  248 EDKWDVVASSF---MIERKCEIENVLY 271
Cdd:PHA03098 465 TNKWTELSSLNfprINASLCIFNNKIY 491
Kelch smart00612
Kelch domain;
181-212 6.88e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 6.88e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 18420521    181 KIYVMGGCAADESKYWAEVFDPKTQTWKPLTD 212
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPS 32
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
159-256 1.07e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.43  E-value: 1.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521 159 AWRKAPSMTVARANVFAYVINGKIYVMGGCAADESKYWAEVFDPKTQTWKPLTD-PGAELrvsSIIGMAVSEGKIYV--- 234
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPlPGPPR---HHAAAVAQDGKLYVfgg 78

                        90       100
                ....*....|....*....|....*....
gi 18420521 235 ------KNSYVKD-YVYDPEEDKWDVVAS 256
Cdd:COG3055  79 ftganpSSTPLNDvYVYDPATNTWTKLAP 107
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
116-256 1.64e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.88  E-value: 1.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521 116 PIPSSYSPRVPMFIGEIGSELYAI--SKHNTPSSVMWVRD-KTSiyAWRKAPSM-TVARANVFAYVINGKIYVMGGCAAD 191
Cdd:COG3055   5 SLPDLPTPRSEAAAALLDGKVYVAggLSGGSASNSFEVYDpATN--TWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGA 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18420521 192 ESKYW----AEVFDPKTQTWKPLTdPGAELRVSSiiGMAVSEGKIYV-----KNSYVKD-YVYDPEEDKWDVVAS 256
Cdd:COG3055  83 NPSSTplndVYVYDPATNTWTKLA-PMPTPRGGA--TALLLDGKIYVvggwdDGGNVAWvEVYDPATGTWTQLAP 154
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
160-256 4.93e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 71.73  E-value: 4.93e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521 160 WRKAPSMTVARANVFAYVINGKIYVMGGCAADESKYWAEVFDPKTQTWKPLTD-PGAELRVSsiiGMAVSEGKIYV---- 234
Cdd:COG3055 102 WTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPlPTPRDHLA---AAVLPDGKILViggr 178

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 18420521 235 -------------------------------------KNSYVKDYVYDPEEDKWDVVAS 256
Cdd:COG3055 179 ngsgfsntwttlaplptaraghaaavlggkilvfggeSGFSDEVEAYDPATNTWTALGE 237
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 19-63 2.40e-13

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 63.74  E-value: 2.40e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18420521  19 SFLSLPEEILVNCLARIPKSYYPKLSLVCKSFCSLILSMELYVER 63
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 169-214 4.77e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.46  E-value: 4.77e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 18420521   169 ARANVFAYVINGKIYVMGGCAADESKYWAEVFDPKTQTWKPLTDPG 214
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
151-234 1.08e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.47  E-value: 1.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521 151 VRDKTSIYAWRKAPSMTVARANVFAYVINGKIYVMGGcaadeSKYW---AEVFDPKTQTWKPLTD-PGAELRVssiiGMA 226
Cdd:COG3055 178 RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG-----ESGFsdeVEAYDPATNTWTALGElPTPRHGH----AAV 248


                ....*...
gi 18420521 227 VSEGKIYV 234
Cdd:COG3055 249 LTDGKVYV 256
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 20-61 9.53e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 45.22  E-value: 9.53e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 18420521    20 FLSLPEEILVNCLARIPKSYYPKLSLVCKSFCSLILSMELYV 61
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
FBOX smart00256
A Receptor for Ubiquitination Targets;
23-63 2.67e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 43.58  E-value: 2.67e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 18420521     23 LPEEILVNCLARIPKSYYPKLSLVCKSFCSLILSMELYVER 63
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
PHA03098 PHA03098
kelch-like protein; Provisional
 146-271 1.35e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.99  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521  146 SSVMWVRDKTSIyaWRKAPSMTVARANVFAYVINGKIYVMGGCAADES----KYWA------------------------ 197
Cdd:PHA03098 311 NSVVSYDTKTKS--WNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlntvESWKpgeskwreepplifprynpcvvnv 388

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521  198 --------------------EVFDPKTQTWKpltdPGAELRVSSIIGMAVS-EGKIYVKN--SYVKD-------YVYDPE 247
Cdd:PHA03098 389 nnliyviggiskndellktvECFSLNTNKWS----KGSPLPISHYGGCAIYhDGKIYVIGgiSYIDNikvynivESYNPV 464

                        170       180
                 ....*....|....*....|....*..
gi 18420521  248 EDKWDVVASSF---MIERKCEIENVLY 271
Cdd:PHA03098 465 TNKWTELSSLNfprINASLCIFNNKIY 491
PLN02193 PLN02193
nitrile-specifier protein
 182-256 4.13e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 42.25  E-value: 4.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521  182 IYVMGGCAADESKYWAEVFDPKTQTWKPLTDPGAELRVSSIIGMAVSEGKIYVKNSY----VKD-YVYDPEEDKWDVVAS 256
Cdd:PLN02193 281 VYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFngceVDDvHYYDPVQDKWTQVET 360
Kelch smart00612
Kelch domain;
181-212 6.88e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 6.88e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 18420521    181 KIYVMGGCAADESKYWAEVFDPKTQTWKPLTD 212
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPS 32
Kelch_6 pfam13964
Kelch motif;
160-213 1.17e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 1.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 18420521   160 WRKAPSMTVaranvfayvINGKIYVMGG-CAADESKYWAEVFDPKTQTWKPLTDP 213
Cdd:pfam13964   1 PRTFHSVVS---------VGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPL 46
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
 19-63 2.56e-03

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 35.28  E-value: 2.56e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18420521  19 SFLSLPEEILVNCLARIPKSYYPKLSLVCKSFCSLILSmELYVER 63
Cdd:cd22143   1 AFDSLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLALP-ELWRSI 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
169-213 2.84e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 2.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 18420521   169 ARANVFAYVI-NGKIYVMGGCAADESKY-WAEVFDPKTQTWKPLTDP 213
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEGEDGTLLsDLWVFDLSTNEWTRLGSL 47
PHA02790 PHA02790
Kelch-like protein; Provisional
 115-208 7.64e-03

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 38.10  E-value: 7.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420521  115 VPIPSSYSPRVPMFIGEIGSELYAISKHNTPSSV-MWVRDKTSiyaWRKAPSMTVARANVFAYVINGKIYVMGGCAadES 193
Cdd:PHA02790 300 IPIPPMNSPRLYASGVPANNKLYVVGGLPNPTSVeRWFHGDAA---WVNMPSLLKPRCNPAVASINNVIYVIGGHS--ET 374

                         90
                 ....*....|....*
gi 18420521  194 KYWAEVFDPKTQTWK 208
Cdd:PHA02790 375 DTTTEYLLPNHDQWQ 389
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
159-201 9.23e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 37.44  E-value: 9.23e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 18420521 159 AWRKAPSMTVARANVFAYVINGKIYVMGGCA----ADESKYWAEVFD 201
Cdd:COG3055 231 TWTALGELPTPRHGHAAVLTDGKVYVIGGETkpgvRTPLVTSAEVYD 277
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 22-56 9.71e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 33.59  E-value: 9.71e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 18420521  22 SLPEEILVNCLARIPKSYYPKLSLVCKSFCSLILS 56
Cdd:cd22157   2 SLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISS 36
PHA03098 PHA03098
kelch-like protein; Provisional
 160-213 9.75e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 37.82  E-value: 9.75e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 18420521  160 WRKAPSMTVARANVFAYVINGKIYVMGGCAADESKYWAEVFDPKTQTWKPLTDP 213
Cdd:PHA03098 468 WTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKF 521
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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